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EDITORIAL

Nicholas R. Cozzarelli

Webcasting is not publication
PNAS 2003 100: 8039. [Extract] [Full Text] [PDF]  

COMMENTARIES

Gerald I. Byrne

Chlamydia uncloaked
PNAS 2003 100: 8040-8042; published online on June 30, 2003, 10.1073/pnas.1533181100 [Extract] [Full Text] [PDF]  
See companion article on page 8478

David A. Greenberg

Linking acquired neurodevelopmental disorders to defects in cell adhesion
PNAS 2003 100: 8043-8044; published online on June 30, 2003, 10.1073/pnas.1533226100 [Extract] [Full Text] [PDF]  
See companion article on page 8543

Jianzhi Zhang

Paleomolecular biology unravels the evolutionary mystery of vertebrate UV vision
PNAS 2003 100: 8045-8047; published online on June 30, 2003, 10.1073/pnas.1533183100 [Extract] [Full Text] [PDF]  
See companion article on page 8308

SPECIAL FEATURE

Introduction

William C. Clark and Nancy M. Dickson

Science and Technology for Sustainable Development Special Feature: Sustainability science: The emerging research program
PNAS 2003 100: 8059-8061; published online on June 6, 2003, 10.1073/pnas.1231333100 [Extract] [Full Text] [PDF]  

PERSPECTIVES

J. B. Gurdon and J. A. Byrne

The first half-century of nuclear transplantation
PNAS 2003 100: 8048-8052; published online on June 23, 2003, 10.1073/pnas.1337135100 [Abstract] [Full Text] [PDF]  

REVIEWS

G. Vereb, J. Szöllosi, J. Matkó, P. Nagy, T. Farkas, L. Vígh, L. Mátyus, T. A. Waldmann, and S. Damjanovich

Dynamic, yet structured: The cell membrane three decades after the Singer–Nicolson model
PNAS 2003 100: 8053-8058; published online on June 27, 2003, 10.1073/pnas.1332550100 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Arthur Fridman

Mixed Markov models
PNAS 2003 100: 8092-8096; published online on June 26, 2003, 10.1073/pnas.0731829100 [Abstract] [Full Text] [PDF]  

Applied Physical Sciences

Chemistry

Hao Yan, Thomas H. LaBean, Liping Feng, and John H. Reif

Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices
PNAS 2003 100: 8103-8108; published online on June 23, 2003, 10.1073/pnas.1032954100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Y. C. Liang, A. S. Dvornikov, and P. M. Rentzepis

Nonvolatile read-out molecular memory
PNAS 2003 100: 8109-8112; published online on June 26, 2003, 10.1073/pnas.0832270100 [Abstract] [Full Text] [PDF]  

Samir Kumar Pal, Liang Zhao, and Ahmed H. Zewail

Water at DNA surfaces: Ultrafast dynamics in minor groove recognition
PNAS 2003 100: 8113-8118; published online on June 18, 2003, 10.1073/pnas.1433066100 [Abstract] [Full Text] [PDF]  

Tianbing Xia, Hans-Christian Becker, Chaozhi Wan, Adam Frankel, Richard W. Roberts, and Ahmed H. Zewail

The RNA–protein complex: Direct probing of the interfacial recognition dynamics and its correlation with biological functions
PNAS 2003 100: 8119-8123; published online on June 18, 2003, 10.1073/pnas.1433099100 [Abstract] [Full Text] [PDF]  

Geology

Daniel H. Rothman, John M. Hayes, and Roger E. Summons

Dynamics of the Neoproterozoic carbon cycle
PNAS 2003 100: 8124-8129; published online on June 24, 2003, 10.1073/pnas.0832439100 [Abstract] [Full Text] [PDF]  

Mathematics

Consuelo Martínez and Efim I. Zelmanov

Lie superalgebras graded by P(n) and Q(n)
PNAS 2003 100: 8130-8137; published online on June 27, 2003, 10.1073/pnas.0932706100 [Abstract] [Full Text] [PDF]  

Juan A. Tirao

The matrix-valued hypergeometric equation
PNAS 2003 100: 8138-8141; published online on June 24, 2003, 10.1073/pnas.1337650100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Erik Trinkaus

Neandertal faces were not long; modern human faces are short
PNAS 2003 100: 8142-8145; published online on June 18, 2003, 10.1073/pnas.1433023100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Biochemistry

Douglas A. Whittington, Kristin M. Rusche, Hyunshun Shin, Carol A. Fierke, and David W. Christianson

Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis
PNAS 2003 100: 8146-8150; published online on June 20, 2003, 10.1073/pnas.1432990100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rosalind Kim, Luhua Lai, Hi-Hong Lee, Gang-Won Cheong, Kyeong Kyu Kim, Zheng Wu, Hisao Yokota, Susan Marqusee, and Sung-Hou Kim

On the mechanism of chaperone activity of the small heat-shock protein of Methanococcus jannaschii
PNAS 2003 100: 8151-8155; published online on June 19, 2003, 10.1073/pnas.1032940100 [Abstract] [Full Text] [PDF]  

Vahe Bandarian, Martha L. Ludwig, and Rowena G. Matthews Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Factors modulating conformational equilibria in large modular proteins: A case study with cobalamin-dependent methionine synthase PNAS 2003 100: 8156-8163; published online on June 27, 2003, 10.1073/pnas.1133218100 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]

Zirong Li, Sara Van Calcar, Chunxu Qu, Webster K. Cavenee, Michael Q. Zhang, and Bing Ren

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
PNAS 2003 100: 8164-8169; published online on June 13, 2003, 10.1073/pnas.1332764100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yoshimitsu Kuwabara, Tomoko Nishino, Ken Okamoto, Tomohiro Matsumura, Bryan T. Eger, Emil F. Pai, and Takeshi Nishino

Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase
PNAS 2003 100: 8170-8175; published online on June 19, 2003, 10.1073/pnas.1431485100 [Abstract] [Full Text] [PDF]  

David Warren, My D. Sam, Kate Manley, Dibyendu Sarkar, Sang Yeol Lee, Mohamad Abbani, Jonathan M. Wojciak, Robert T. Clubb, and Arthur Landy

Identification of the integrase surface that interacts with Xis reveals a residue that is also critical for Int dimer formation
PNAS 2003 100: 8176-8181; published online on June 27, 2003, 10.1073/pnas.1033041100 [Abstract] [Full Text] [PDF]  

Tobin J. Dickerson and Kim D. Janda

Glycation of the amyloid -protein by a nicotine metabolite: A fortuitous chemical dynamic between smoking and Alzheimer's disease
PNAS 2003 100: 8182-8187; published online on June 18, 2003, 10.1073/pnas.1332847100 [Abstract] [Full Text] [PDF]  

Christian Siebold, Luis Fernando García-Alles, Bernhard Erni, and Ulrich Baumann

A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase
PNAS 2003 100: 8188-8192; published online on June 17, 2003, 10.1073/pnas.0932787100 [Abstract] [Full Text] [PDF]  

Osamu Imamura and Judith L. Campbell

The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants
PNAS 2003 100: 8193-8198; published online on June 25, 2003, 10.1073/pnas.1431624100 [Abstract] [Full Text] [PDF]  

Ingeborg Hanbauer, Emily S. Boja, and Jackob Moskovitz

A homologue of elongation factor 1 regulates methionine sulfoxide reductase A gene expression in Saccharomyces cerevisiae
PNAS 2003 100: 8199-8204; published online on June 24, 2003, 10.1073/pnas.1432898100 [Abstract] [Full Text] [PDF]  

Tomoko Komiyama, Bryan VanderLugt, Martin Fugère, Robert Day, Randal J. Kaufman, and Robert S. Fuller

Optimization of protease-inhibitor interactions by randomizing adventitious contacts
PNAS 2003 100: 8205-8210; published online on June 27, 2003, 10.1073/pnas.1032865100 [Abstract] [Full Text] [PDF]  

Tim Veldman, Xuefeng Liu, Hang Yuan, and Richard Schlegel

Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter
PNAS 2003 100: 8211-8216; published online on June 23, 2003, 10.1073/pnas.1435900100 [Abstract] [Full Text] [PDF]  

Biophysics

Emanuele Paci, Andrea Cavalli, Michele Vendruscolo, and Amedeo Caflisch

Analysis of the distributed computing approach applied to the folding of a small peptide
PNAS 2003 100: 8217-8222; published online on June 18, 2003, 10.1073/pnas.1331838100 [Abstract] [Full Text] [PDF]  

Bernardo A. Mello and Yuhai Tu

Quantitative modeling of sensitivity in bacterial chemotaxis: The role of coupling among different chemoreceptor species
PNAS 2003 100: 8223-8228; published online on June 25, 2003, 10.1073/pnas.1330839100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cell Biology

Ying Wu, Matthew T. Swulius, Kelley W. Moremen, and Richard N. Sifers

Elucidation of the molecular logic by which misfolded 1-antitrypsin is preferentially selected for degradation
PNAS 2003 100: 8229-8234; published online on June 18, 2003, 10.1073/pnas.1430537100 [Abstract] [Full Text] [PDF]  

Ellen M. Judd, Kathleen R. Ryan, W. E. Moerner, Lucy Shapiro, and Harley H. McAdams

Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter
PNAS 2003 100: 8235-8240; published online on June 24, 2003, 10.1073/pnas.1433105100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lawrence Rajendran, Madhan Masilamani, Samuel Solomon, Ritva Tikkanen, Claudia A. O. Stuermer, Helmut Plattner, and Harald Illges

Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells
PNAS 2003 100: 8241-8246; published online on June 25, 2003, 10.1073/pnas.1331629100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Leonard Girnita, Ada Girnita, and Olle Larsson

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
PNAS 2003 100: 8247-8252; published online on June 23, 2003, 10.1073/pnas.1431613100 [Abstract] [Full Text] [PDF]  

Constanze Reinhard, Michael Schweikert, Felix T. Wieland, and Walter Nickel

Functional reconstitution of COPI coat assembly and disassembly using chemically defined components
PNAS 2003 100: 8253-8257; published online on June 27, 2003, 10.1073/pnas.1432391100 [Abstract] [Full Text] [PDF]  

Robson A. S. Santos, Ana C. Simoes e Silva, Christine Maric, Denise M. R. Silva, Raquel Pillar Machado, Insa de Buhr, Silvia Heringer-Walther, Sergio Veloso B. Pinheiro, Myriam Teresa Lopes, Michael Bader, Elizabeth P. Mendes, Virgina Soares Lemos, Maria Jose Campagnole-Santos, Heinz-Peter Schultheiss, Robert Speth, and Thomas Walther

Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
PNAS 2003 100: 8258-8263; published online on June 26, 2003, 10.1073/pnas.1432869100 [Abstract] [Full Text] [PDF]  

Puri Fortes, Yolanda Cuevas, Fei Guan, Peng Liu, Sara Pentlicky, Stephen P. Jung, Maria L. Martínez-Chantar, Jesús Prieto, David Rowe, and Samuel I. Gunderson

Inhibiting expression of specific genes in mammalian cells with 5' end-mutated U1 small nuclear RNAs targeted to terminal exons of pre-mRNA
PNAS 2003 100: 8264-8269; published online on June 25, 2003, 10.1073/pnas.1332669100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Thierry Fischer, Luc De Vries, Timo Meerloo, and Marilyn Gist Farquhar

Promotion of Gi3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP
PNAS 2003 100: 8270-8275; published online on June 25, 2003, 10.1073/pnas.1432965100 [Abstract] [Full Text] [PDF]  

Shinobu Suzuki, Nobutaka Suzuki, Christine Mirtsos, Thomas Horacek, Elizabeth Lye, Seo-Kyu Noh, Alexandra Ho, Denis Bouchard, Tak W. Mak, and Wen-Chen Yeh

Nur77 as a survival factor in tumor necrosis factor signaling
PNAS 2003 100: 8276-8280; published online on June 18, 2003, 10.1073/pnas.0932598100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Hester Tidcombe, Amy Jackson-Fisher, Kathleen Mathers, David F. Stern, Martin Gassmann, and Jon P. Golding

Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality
PNAS 2003 100: 8281-8286; published online on June 24, 2003, 10.1073/pnas.1436402100 [Abstract] [Full Text] [PDF]  

Georgette L. Sass, Antonio Pannuti, and John C. Lucchesi

Male-specific lethal complex of Drosophila targets activated regions of the X chromosome for chromatin remodeling
PNAS 2003 100: 8287-8291; published online on June 26, 2003, 10.1073/pnas.1332749100 [Abstract] [Full Text] [PDF]  

Marika Charalambous, Florentia M. Smith, William R. Bennett, Tracey E. Crew, Francesca Mackenzie, and Andrew Ward

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism
PNAS 2003 100: 8292-8297; published online on June 26, 2003, 10.1073/pnas.1532175100 [Abstract] [Full Text] [PDF]  

Ecology

Robert W. Kates and Thomas M. Parris

Science and Technology for Sustainable Development Special Feature: Long-term trends and a sustainability transition
PNAS 2003 100: 8062-8067; published online on June 26, 2003, 10.1073/pnas.1231331100 [Abstract] [Full Text] [PDF]  

Thomas M. Parris and Robert W. Kates

Science and Technology for Sustainable Development Special Feature: Characterizing a sustainability transition: Goals, targets, trends, and driving forces
PNAS 2003 100: 8068-8073; published online on June 20, 2003, 10.1073/pnas.1231336100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

B. L. Turner, II, Roger E. Kasperson, Pamela A. Matson, James J. McCarthy, Robert W. Corell, Lindsey Christensen, Noelle Eckley, Jeanne X. Kasperson, Amy Luers, Marybeth L. Martello, Colin Polsky, Alexander Pulsipher, and Andrew Schiller

Science and Technology for Sustainable Development Special Feature: A framework for vulnerability analysis in sustainability science
PNAS 2003 100: 8074-8079; published online on June 5, 2003, 10.1073/pnas.1231335100 [Abstract] [Full Text] [PDF]  

B. L. Turner, II, Pamela A. Matson, James J. McCarthy, Robert W. Corell, Lindsey Christensen, Noelle Eckley, Grete K. Hovelsrud-Broda, Jeanne X. Kasperson, Roger E. Kasperson, Amy Luers, Marybeth L. Martello, Svein Mathiesen, Rosamond Naylor, Colin Polsky, Alexander Pulsipher, Andrew Schiller, Henrik Selin, and Nicholas Tyler Science and Technology for Sustainable Development Special Feature: Illustrating the coupled human–environment system for vulnerability analysis: Three case studies PNAS 2003 100: 8080-8085; published online on June 18, 2003, 10.1073/pnas.1231334100 [Abstract] [Full Text] [PDF]

David W. Cash, William C. Clark, Frank Alcock, Nancy M. Dickson, Noelle Eckley, David H. Guston, Jill Jäger, and Ronald B. Mitchell

Science and Technology for Sustainable Development Special Feature: Knowledge systems for sustainable development
PNAS 2003 100: 8086-8091; published online on May 30, 2003, 10.1073/pnas.1231332100 [Abstract] [Full Text] [PDF]  

F. O. Glöckner, M. Kube, M. Bauer, H. Teeling, T. Lombardot, W. Ludwig, D. Gade, A. Beck, K. Borzym, K. Heitmann, R. Rabus, H. Schlesner, R. Amann, and R. Reinhardt

Complete genome sequence of the marine planctomycete Pirellula sp. strain 1
PNAS 2003 100: 8298-8303; published online on June 30, 2003, 10.1073/pnas.1431443100 [Abstract] [Full Text] [PDF] [Supporting Appendixes]  

Sunshine A. Van Bael, Jeffrey D. Brawn, and Scott K. Robinson Birds defend trees from herbivores in a Neotropical forest canopy PNAS 2003 100: 8304-8307; published online on June 27, 2003, 10.1073/pnas.1431621100 [Abstract] [Full Text] [PDF]

Evolution

Jun-Yuan Chen, Di-Ying Huang, Qing-Qing Peng, Hui-Mei Chi, Xiu-Qiang Wang, and Man Feng

The first tunicate from the Early Cambrian of South China
PNAS 2003 100: 8314-8318; published online on June 30, 2003, 10.1073/pnas.1431177100 [Abstract] [Full Text] [PDF]  

Stephen W. Schaeffer, M. Paula Goetting-Minesky, Miro Kovacevic, John R. Peoples, Jennifer L. Graybill, Jonathan M. Miller, Kyungsun Kim, Julie G. Nelson, and Wyatt W. Anderson

Evolutionary genomics of inversions in Drosophila pseudoobscura: Evidence for epistasis
PNAS 2003 100: 8319-8324; published online on June 24, 2003, 10.1073/pnas.1432900100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Christophe J. Douady, François Catzeflis, Jaishree Raman, Mark S. Springer, and Michael J. Stanhope

The Sahara as a vicariant agent, and the role of Miocene climatic events, in the diversification of the mammalian order Macroscelidea (elephant shrews)
PNAS 2003 100: 8325-8330; published online on June 23, 2003, 10.1073/pnas.0832467100 [Abstract] [Full Text] [PDF]  

Jinxiu Shi, Huifeng Xi, Ying Wang, Chenghui Zhang, Zhengwen Jiang, Kuixing Zhang, Yayun Shen, Lin Jin, Kaiyue Zhang, Wentao Yuan, Ying Wang, Jie Lin, Qi Hua, Fengqing Wang, Shuhua Xu, Suangxi Ren, Shijie Xu, Guoping Zhao, Zhu Chen, Li Jin, and Wei Huang

Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription units
PNAS 2003 100: 8331-8336; published online on June 25, 2003, 10.1073/pnas.1332748100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Jianzhi Zhang and David M. Webb

Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates
PNAS 2003 100: 8337-8341; published online on June 25, 2003, 10.1073/pnas.1331721100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Genetics

Zhen-Biao Xia, Melanie Anderson, Manuel O. Diaz, and Nancy J. Zeleznik-Le

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein
PNAS 2003 100: 8342-8347; published online on June 26, 2003, 10.1073/pnas.1436338100 [Abstract] [Full Text] [PDF]  

Olga G. Troyanskaya, Kara Dolinski, Art B. Owen, Russ B. Altman, and David Botstein

A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae)
PNAS 2003 100: 8348-8353; published online on June 25, 2003, 10.1073/pnas.0832373100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Krystyna Mazan-Mamczarz, Stefanie Galbán, Isabel López de Silanes, Jennifer L. Martindale, Ulus Atasoy, Jack D. Keene, and Myriam Gorospe

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
PNAS 2003 100: 8354-8359; published online on June 23, 2003, 10.1073/pnas.1432104100 [Abstract] [Full Text] [PDF]  

Mitchell L. Klebig, Melissa D. Wall, Mark D. Potter, Erica L. Rowe, Donald A. Carpenter, and Eugene M. Rinchik

Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice
PNAS 2003 100: 8360-8365; published online on June 27, 2003, 10.1073/pnas.1432634100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Marco Marini, Giorgos Bamias, Jesús Rivera-Nieves, Christopher A. Moskaluk, Sharon B. Hoang, William G. Ross, Theresa T. Pizarro, and Fabio Cominelli

TNF-neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis
PNAS 2003 100: 8366-8371; published online on June 27, 2003, 10.1073/pnas.1432897100 [Abstract] [Full Text] [PDF]  

Giao Q. Phan, James C. Yang, Richard M. Sherry, Patrick Hwu, Suzanne L. Topalian, Douglas J. Schwartzentruber, Nicholas P. Restifo, Leah R. Haworth, Claudia A. Seipp, Linda J. Freezer, Kathleen E. Morton, Sharon A. Mavroukakis, Paul H. Duray, Seth M. Steinberg, James P. Allison, Thomas A. Davis, and Steven A. Rosenberg

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
PNAS 2003 100: 8372-8377; published online on June 25, 2003, 10.1073/pnas.1533209100 [Abstract] [Full Text] [PDF]  

H. Jiang, S. Curran, E. Ruiz-Vazquez, B. Liang, R. Winchester, and L. Chess

Regulatory CD8⁺ T cells fine-tune the myelin basic protein-reactive T cell receptor V repertoire during experimental autoimmune encephalomyelitis
PNAS 2003 100: 8378-8383; published online on June 24, 2003, 10.1073/pnas.1432871100 [Abstract] [Full Text] [PDF]  

Scott M. Lieberman, Anne M. Evans, Bingye Han, Toshiyuki Takaki, Yuliya Vinnitskaya, Jennifer A. Caldwell, David V. Serreze, Jeffrey Shabanowitz, Donald F. Hunt, Stanley G. Nathenson, Pere Santamaria, and Teresa P. DiLorenzo

Identification of the cell antigen targeted by a prevalent population of pathogenic CD8⁺ T cells in autoimmune diabetes
PNAS 2003 100: 8384-8388; published online on June 18, 2003, 10.1073/pnas.0932778100 [Abstract] [Full Text] [PDF]  

Pia Kivisäkk, Don J. Mahad, Melissa K. Callahan, Corinna Trebst, Barbara Tucky, Tao Wei, Lijun Wu, Espen S. Baekkevold, Hans Lassmann, Susan M. Staugaitis, James J. Campbell, and Richard M. Ransohoff

Human cerebrospinal fluid central memory CD4⁺ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin
PNAS 2003 100: 8389-8394; published online on June 26, 2003, 10.1073/pnas.1433000100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Jennifer L. Matsuda, Laurent Gapin, Jody L. Baron, Stéphane Sidobre, Daniel B. Stetson, Markus Mohrs, Richard M. Locksley, and Mitchell Kronenberg

Mouse V14i natural killer T cells are resistant to cytokine polarization in vivo
PNAS 2003 100: 8395-8400; published online on June 26, 2003, 10.1073/pnas.1332805100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Medical Sciences

Tatsuyoshi Kawamura, Forrest O. Gulden, Makoto Sugaya, David T. McNamara, Debra L. Borris, Michael M. Lederman, Jan M. Orenstein, Peter A. Zimmerman, and Andrew Blauvelt

R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms
PNAS 2003 100: 8401-8406; published online on June 18, 2003, 10.1073/pnas.1432450100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Luis A. Ortiz, Frederica Gambelli, Christine McBride, Dina Gaupp, Melody Baddoo, Naftali Kaminski, and Donald G. Phinney

Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects
PNAS 2003 100: 8407-8411; published online on June 18, 2003, 10.1073/pnas.1432929100 [Abstract] [Full Text] [PDF]  

Hui Li, Lois Myeroff, Dominic Smiraglia, Michael F. Romero, Theresa P. Pretlow, Lakshmi Kasturi, James Lutterbaugh, Ronald M. Rerko, Graham Casey, Jean-Pierre Issa, Joseph Willis, James K. V. Willson, Christoph Plass, and Sanford D. Markowitz

SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
PNAS 2003 100: 8412-8417; published online on June 26, 2003, 10.1073/pnas.1430846100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Therese Sørlie, Robert Tibshirani, Joel Parker, Trevor Hastie, J. S. Marron, Andrew Nobel, Shibing Deng, Hilde Johnsen, Robert Pesich, Stephanie Geisler, Janos Demeter, Charles M. Perou, Per E. Lønning, Patrick O. Brown, Anne-Lise Børresen-Dale, and David Botstein

Repeated observation of breast tumor subtypes in independent gene expression data sets
PNAS 2003 100: 8418-8423; published online on June 26, 2003, 10.1073/pnas.0932692100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shunsuke Kato, Shuang-Yin Han, Wen Liu, Kazunori Otsuka, Hiroyuki Shibata, Ryunosuke Kanamaru, and Chikashi Ishioka

Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
PNAS 2003 100: 8424-8429; published online on June 25, 2003, 10.1073/pnas.1431692100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Peter M. Siegel, Weiping Shu, Robert D. Cardiff, William J. Muller, and Joan Massagué

Transforming growth factor signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
PNAS 2003 100: 8430-8435; published online on June 13, 2003, 10.1073/pnas.0932636100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Donald Metcalf, Sandra Mifsud, Ladina Di Rago, and Warren S. Alexander

The lethal effects of transplantation of Socs1^-/- bone marrow cells into irradiated adult syngeneic recipients
PNAS 2003 100: 8436-8441; published online on June 23, 2003, 10.1073/pnas.1032925100 [Abstract] [Full Text] [PDF]  

Yuko Shoya, Kenzo Tokunaga, Hirofumi Sawa, Masae Maeda, Tomonori Ueno, Tomoki Yoshikawa, Hideki Hasegawa, Tetsutaro Sata, Takeshi Kurata, William W. Hall, Bryan R. Cullen, and Hidehiro Takahashi

Human topoisomerase I promotes HIV-1 proviral DNA synthesis: Implications for the species specificity and cellular tropism of HIV-1 infection
PNAS 2003 100: 8442-8447; published online on June 26, 2003, 10.1073/pnas.1430827100 [Abstract] [Full Text] [PDF]  

Björn Steffen, Hubert Serve, Wolfgang E. Berdel, Shuchi Agrawal, Bryan Linggi, Thomas Büchner, Scott W. Hiebert, and Carsten Müller-Tidow

Specific protein redirection as a transcriptional therapy approach for t(8;21) leukemia
PNAS 2003 100: 8448-8453; published online on June 20, 2003, 10.1073/pnas.1330293100 [Abstract] [Full Text] [PDF]  

Lizhe Xu, Zhiwei Shen, Linsheng Guo, Brent Fodera, Adrian Keogh, Ruth Joplin, Barbara O'Donnell, James Aitken, William Carman, James Neuberger, and Andrew Mason

Does a betaretrovirus infection trigger primary biliary cirrhosis?
PNAS 2003 100: 8454-8459; published online on June 27, 2003, 10.1073/pnas.1433063100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yong-Hui Zheng, Ana Plemenitas, Christopher J. Fielding, and B. Matija Peterlin

Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions
PNAS 2003 100: 8460-8465; published online on June 24, 2003, 10.1073/pnas.1437453100 [Abstract] [Full Text] [PDF]  

Mary Elizabeth Patti, Atul J. Butte, Sarah Crunkhorn, Kenneth Cusi, Rachele Berria, Sangeeta Kashyap, Yoshinori Miyazaki, Isaac Kohane, Maura Costello, Robert Saccone, Edwin J. Landaker, Allison B. Goldfine, Edward Mun, Ralph DeFronzo, Jean Finlayson, C. Ronald Kahn, and Lawrence J. Mandarino

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
PNAS 2003 100: 8466-8471; published online on June 27, 2003, 10.1073/pnas.1032913100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Erik I. Christensen, Olivier Devuyst, Geneviève Dom, Rikke Nielsen, Patrick Van Der Smissen, Pierre Verroust, Michèle Leruth, William B. Guggino, and Pierre J. Courtoy

Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules
PNAS 2003 100: 8472-8477; published online on June 18, 2003, 10.1073/pnas.1432873100 [Abstract] [Full Text] [PDF]  

Microbiology

Matthew C. Wolfgang, Bridget R. Kulasekara, Xiaoyou Liang, Dana Boyd, Kai Wu, Qing Yang, C. Garrett Miyada, and Stephen Lory

Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa
PNAS 2003 100: 8484-8489; published online on June 18, 2003, 10.1073/pnas.0832438100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yuying Liang and Don Ganem

Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling
PNAS 2003 100: 8490-8495; published online on June 27, 2003, 10.1073/pnas.1432843100 [Abstract] [Full Text] [PDF]  

Jeffrey M. Schapiro, Stephen J. Libby, and Ferric C. Fang

Inhibition of bacterial DNA replication by zinc mobilization during nitrosative stress
PNAS 2003 100: 8496-8501; published online on June 26, 2003, 10.1073/pnas.1033133100 [Abstract] [Full Text] [PDF]  

Xiaorong Feng, Jane M. Carlton, Deirdre A. Joy, Jianbing Mu, Tetsuya Furuya, Bernard B. Suh, Yufeng Wang, John W. Barnwell, and Xin-Zhuan Su

Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax
PNAS 2003 100: 8502-8507; published online on June 10, 2003, 10.1073/pnas.1232502100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Long Hang, Manohar John, Muhammad Asaduzzaman, Emily Anna Bridges, Cecily Vanderspurt, Thomas J. Kirn, Ronald K. Taylor, Jeffrey D. Hillman, Ann Progulske-Fox, Martin Handfield, Edward T. Ryan, and Stephen B. Calderwood

Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae
PNAS 2003 100: 8508-8513; published online on June 25, 2003, 10.1073/pnas.1431769100 [Abstract] [Full Text] [PDF]  

Neuroscience

Seija Lehnardt, Leon Massillon, Pamela Follett, Frances E. Jensen, Rajiv Ratan, Paul A. Rosenberg, Joseph J. Volpe, and Timothy Vartanian

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
PNAS 2003 100: 8514-8519; published online on June 24, 2003, 10.1073/pnas.1432609100 [Abstract] [Full Text] [PDF]  

Stanislas Dehaene, Claire Sergent, and Jean-Pierre Changeux

A neuronal network model linking subjective reports and objective physiological data during conscious perception
PNAS 2003 100: 8520-8525; published online on June 26, 2003, 10.1073/pnas.1332574100 [Abstract] [Full Text] [PDF]  

Ruolan Liu, Ingrid Y. Liu, Xiaoning Bi, Richard F. Thompson, Susan R. Doctrow, Bernard Malfroy, and Michel Baudry

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics
PNAS 2003 100: 8526-8531; published online on June 18, 2003, 10.1073/pnas.1332809100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Lidong Liu, Jane E. Cavanaugh, Yupeng Wang, Hiroyuki Sakagami, Zixu Mao, and Zhengui Xia

ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons
PNAS 2003 100: 8532-8537; published online on June 25, 2003, 10.1073/pnas.1332804100 [Abstract] [Full Text] [PDF]  

Robert C. Coghill, John G. McHaffie, and Ye-Fen Yen

Neural correlates of interindividual differences in the subjective experience of pain
PNAS 2003 100: 8538-8542; published online on June 24, 2003, 10.1073/pnas.1430684100 [Abstract] [Full Text] [PDF]  

Pharmacology

Catherine Rougeot, Michaël Messaoudi, Véronique Hermitte, Anne Gaëlle Rigault, Thierry Blisnick, Christophe Dugave, Didier Desor, and François Rougeon

Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity
PNAS 2003 100: 8549-8554; published online on June 30, 2003, 10.1073/pnas.1431850100 [Abstract] [Full Text] [PDF] [Supporting Information]  

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