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COMMENTARIES

Clark Spencer Larsen

Equality for the sexes in human evolution? Early hominid sexual dimorphism and implications for mating systems and social behavior
PNAS 2003 100: 9103-9104; published online before print July 28 2003, 10.1073/pnas.1633678100 [Extract] [Full Text] [PDF]  
See companion article on page 9404

Robert R. Birge and Barry E. Knox

Perspectives on the counterion switch-induced photoactivation of the G protein-coupled receptor rhodopsin
PNAS 2003 100: 9105-9107; published online before print July 28 2003, 10.1073/pnas.1733801100 [Extract] [Full Text] [PDF]  
See companion article on page 9262

Timothy D. Warner and Jane A. Mitchell

Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: As easy as ABC?
PNAS 2003 100: 9108-9110; published online before print July 28 2003, 10.1073/pnas.1733826100 [Extract] [Full Text] [PDF]  
See companion article on page 9244

Mark R. Cookson

Crystallizing ideas about Parkinson's disease
PNAS 2003 100: 9111-9113; published online before print July 28 2003, 10.1073/pnas.1633722100 [Extract] [Full Text] [PDF]  
See companion article on page 9256

Alan R. Rogers

Economics and the evolution of life histories
PNAS 2003 100: 9114-9115; published online before print July 28 2003, 10.1073/pnas.1733942100 [Extract] [Full Text] [PDF]  
See companion article on page 9637

PHYSICAL SCIENCES

Chemistry

David J. Vocadlo, Howard C. Hang, Eun-Ju Kim, John A. Hanover, and Carolyn R. Bertozzi

A chemical approach for identifying O-GlcNAc-modified proteins in cells
PNAS 2003 100: 9116-9121; published online before print July 21 2003, 10.1073/pnas.1632821100 [Abstract] [Full Text] [PDF] [Supporting Information] [Online Correction to Supporting Schemes 2 and 3]  

Adam J. Moulé, Megan M. Spence, Song-I Han, Juliette A. Seeley, Kimberly L. Pierce, Sunil Saxena, and Alexander Pines

Amplification of xenon NMR and MRI by remote detection
PNAS 2003 100: 9122-9127; published online before print July 22 2003, 10.1073/pnas.1133497100 [Abstract] [Full Text] [PDF]  

Statistics

John D. Storey and Robert Tibshirani

Statistical significance for genomewide studies
PNAS 2003 100: 9440-9445; published online before print July 25 2003, 10.1073/pnas.1530509100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Social Sciences

BIOLOGICAL SCIENCES

Agricultural Sciences

Junqi Song, James M. Bradeen, S. Kristine Naess, John A. Raasch, Susan M. Wielgus, Geraldine T. Haberlach, Jia Liu, Hanhui Kuang, Sandra Austin-Phillips, C. Robin Buell, John P. Helgeson, and Jiming Jiang

Gene RB cloned from Solanum bulbocastanum confers broad spectrum resistance to potato late blight
PNAS 2003 100: 9128-9133; published online before print July 18 2003, 10.1073/pnas.1533501100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Applied Biological Sciences

Chunhai Fan, Kevin W. Plaxco, and Alan J. Heeger

Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA
PNAS 2003 100: 9134-9137; published online before print July 16 2003, 10.1073/pnas.1633515100 [Abstract] [Full Text] [PDF]  

Mini Thomas and Alexander M. Klibanov

Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells
PNAS 2003 100: 9138-9143; published online before print July 28 2003, 10.1073/pnas.1233634100 [Abstract] [Full Text] [PDF]  

Biochemistry

Helga C. Lichtenegger, Thomas Schöberl, Janne T. Ruokolainen, Julie O. Cross, Steve M. Heald, Henrik Birkedal, J. Herbert Waite, and Galen D. Stucky

Zinc and mechanical prowess in the jaws of Nereis, a marine worm
PNAS 2003 100: 9144-9149; published online before print July 28 2003, 10.1073/pnas.1632658100 [Abstract] [Full Text] [PDF]  

Igor N. Chesnokov, Olga N. Chesnokova, and Michael Botchan

A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity
PNAS 2003 100: 9150-9155; published online before print July 23 2003, 10.1073/pnas.1633580100 [Abstract] [Full Text] [PDF]  

Ken'ichi Moto, Toyoshi Yoshiga, Masanobu Yamamoto, Shunya Takahashi, Kazuhiro Okano, Tetsu Ando, Tadashi Nakata, and Shogo Matsumoto Pheromone gland-specific fatty-acyl reductase of the silkmoth, Bombyx mori PNAS 2003 100: 9156-9161; published online before print July 18 2003, 10.1073/pnas.1531993100 [Abstract] [Full Text] [PDF]

Zheyong Yu, Claus Schneider, William E. Boeglin, Lawrence J. Marnett, and Alan R. Brash

The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase
PNAS 2003 100: 9162-9167; published online before print July 24 2003, 10.1073/pnas.1633612100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Inna P. Gladysheva, Ryan B. Turner, Irina Y. Sazonova, Lin Liu, and Guy L. Reed

Coevolutionary patterns in plasminogen activation
PNAS 2003 100: 9168-9172; published online before print July 23 2003, 10.1073/pnas.1631716100 [Abstract] [Full Text] [PDF]  

Linda Miallau, Magnus S. Alphey, Lauris E. Kemp, Gordon A. Leonard, Sean M. McSweeney, Stefan Hecht, Adelbert Bacher, Wolfgang Eisenreich, Felix Rohdich, and William N. Hunter

Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
PNAS 2003 100: 9173-9178; published online before print July 23 2003, 10.1073/pnas.1533425100 [Abstract] [Full Text] [PDF]  

Wendell L. Roelofs and Alejandro P. Rooney

Molecular genetics and evolution of pheromone biosynthesis in Lepidoptera
PNAS 2003 100: 9179-9184; published online before print July 22 2003, 10.1073/pnas.1233767100 [Abstract] [Full Text] [PDF]  

Santiago Cal, Víctor Quesada, Cecilia Garabaya, and Carlos López-Otín

Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product
PNAS 2003 100: 9185-9190; published online before print July 28 2003, 10.1073/pnas.1633392100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Martin Sagermann, Leslie Gay, and Brian W. Matthews

Long-distance conformational changes in a protein engineered by modulated sequence duplication
PNAS 2003 100: 9191-9195; published online before print July 17 2003, 10.1073/pnas.1633549100 [Abstract] [Full Text] [PDF]  

Katrina M. Miranda, Nazareno Paolocci, Tatsuo Katori, Douglas D. Thomas, Eleonora Ford, Michael D. Bartberger, Michael G. Espey, David A. Kass, Martin Feelisch, Jon M. Fukuto, and David A. Wink

A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system
PNAS 2003 100: 9196-9201; published online before print July 15 2003, 10.1073/pnas.1430507100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Clark C. Fjeld, William T. Birdsong, and Richard H. Goodman

Differential binding of NAD⁺ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor
PNAS 2003 100: 9202-9207; published online before print July 18 2003, 10.1073/pnas.1633591100 [Abstract] [Full Text] [PDF]  

Emil Martin, Iraida Sharina, Alexander Kots, and Ferid Murad

A constitutively activated mutant of human soluble guanylyl cyclase (sGC): Implication for the mechanism of sGC activation
PNAS 2003 100: 9208-9213; published online before print July 25 2003, 10.1073/pnas.1633590100 [Abstract] [Full Text] [PDF]  

Gye Won Han, Mary L. Kopka, David Langs, Michael R. Sawaya, and Richard E. Dickerson

Crystal structure of an RNA·DNA hybrid reveals intermolecular intercalation: Dimer formation by base-pair swapping
PNAS 2003 100: 9214-9219; published online before print July 18 2003, 10.1073/pnas.1533326100 [Abstract] [Full Text] [PDF]  

Toru Kumagai, Makoto Katsumata, Akihiro Hasegawa, Keiji Furuuchi, Toshiki Funakoshi, Ichiro Kawase, and Mark I. Greene

Role of extracellular subdomains of p185^c-neu and the epidermal growth factor receptor in ligand-independent association and transactivation
PNAS 2003 100: 9220-9225; published online before print July 16 2003, 10.1073/pnas.1633546100 [Abstract] [Full Text] [PDF]  

Chi-hong B. Chen, George A. Chernis, Van Q. Hoang, and Ralf Landgraf

Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3
PNAS 2003 100: 9226-9231; published online before print July 21 2003, 10.1073/pnas.1332660100 [Abstract] [Full Text] [PDF]  

Rebecca W. Corbin, Oleg Paliy, Feng Yang, Jeffrey Shabanowitz, Mark Platt, Charles E. Lyons, Jr., Karen Root, Jon McAuliffe, Michael I. Jordan, Sydney Kustu, Eric Soupene, and Donald F. Hunt

Toward a protein profile of Escherichia coli: Comparison to its transcription profile
PNAS 2003 100: 9232-9237; published online before print July 23 2003, 10.1073/pnas.1533294100 [Abstract] [Full Text] [PDF]  

Anne M. Mulichak, Heather C. Losey, Wei Lu, Zdzislaw Wawrzak, Christopher T. Walsh, and R. Michael Garavito

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway
PNAS 2003 100: 9238-9243; published online before print July 21 2003, 10.1073/pnas.1233577100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Glen Reid, Peter Wielinga, Noam Zelcer, Ingrid van der Heijden, Annemieke Kuil, Marcel de Haas, Jan Wijnholds, and Piet Borst

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs
PNAS 2003 100: 9244-9249; published online before print June 30 2003, 10.1073/pnas.1033060100 [Abstract] [Full Text] [PDF]  
See Commentary on page 9108

Elena K. Davydova and Lucia B. Rothman-Denes

Escherichia coli single-stranded DNA-binding protein mediates template recycling during transcription by bacteriophage N4 virion RNA polymerase
PNAS 2003 100: 9250-9255; published online before print July 22 2003, 10.1073/pnas.1133325100 [Abstract] [Full Text] [PDF]  

Biophysics

Elsa C. Y. Yan, Manija A. Kazmi, Ziad Ganim, Jian-Min Hou, Douhai Pan, Belinda S. W. Chang, Thomas P. Sakmar, and Richard A. Mathies Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin PNAS 2003 100: 9262-9267; published online before print June 30 2003, 10.1073/pnas.1531970100 [Abstract] [Full Text] [PDF]   See Commentary on page 9105

De-Bin Huang, Don Vu, Laura A. Cassiday, Jeff M. Zimmerman, L. James Maher, III, and Gourisankar Ghosh

Crystal structure of NF-B (p50)₂ complexed to a high-affinity RNA aptamer
PNAS 2003 100: 9268-9273; published online before print July 28 2003, 10.1073/pnas.1632011100 [Abstract] [Full Text] [PDF] [Supporting Information]  

I. B. Bischofs and U. S. Schwarz

Cell organization in soft media due to active mechanosensing
PNAS 2003 100: 9274-9279; published online before print July 25 2003, 10.1073/pnas.1233544100 [Abstract] [Full Text] [PDF]  

Melike Lakadamyali, Michael J. Rust, Hazen P. Babcock, and Xiaowei Zhuang

Visualizing infection of individual influenza viruses
PNAS 2003 100: 9280-9285; published online before print July 25 2003, 10.1073/pnas.0832269100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Saravanakumar Narayanan, Benjamin Bösl, Stefan Walter, and Bernd Reif

Importance of low-oligomeric-weight species for prion propagation in the yeast prion system Sup35/Hsp104
PNAS 2003 100: 9286-9291; published online before print July 22 2003, 10.1073/pnas.1233535100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Alex Evilevitch, Laurence Lavelle, Charles M. Knobler, Eric Raspaud, and William M. Gelbart

Osmotic pressure inhibition of DNA ejection from phage
PNAS 2003 100: 9292-9295; published online before print July 24 2003, 10.1073/pnas.1233721100 [Abstract] [Full Text] [PDF]  

Christine C. Conwell, Igor D. Vilfan, and Nicholas V. Hud

Controlling the size of nanoscale toroidal DNA condensates with static curvature and ionic strength
PNAS 2003 100: 9296-9301; published online before print July 18 2003, 10.1073/pnas.1533135100 [Abstract] [Full Text] [PDF]  

Gregory Bokinsky, David Rueda, Vinod K. Misra, Maria M. Rhodes, Andrew Gordus, Hazen P. Babcock, Nils G. Walter, and Xiaowei Zhuang

Single-molecule transition-state analysis of RNA folding
PNAS 2003 100: 9302-9307; published online before print July 17 2003, 10.1073/pnas.1133280100 [Abstract] [Full Text] [PDF]  

Elliot Tan, Timothy J. Wilson, Michelle K. Nahas, Robert M. Clegg, David M. J. Lilley, and Taekjip Ha

A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate
PNAS 2003 100: 9308-9313; published online before print July 25 2003, 10.1073/pnas.1233536100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ryohei Yasuda, Tomoko Masaike, Kengo Adachi, Hiroyuki Noji, Hiroyasu Itoh, and Kazuhiko Kinosita, Jr.

The ATP-waiting conformation of rotating F₁-ATPase revealed by single-pair fluorescence resonance energy transfer
PNAS 2003 100: 9314-9318; published online before print July 22 2003, 10.1073/pnas.1637860100 [Abstract] [Full Text] [PDF]  

Florence Tama, Mikel Valle, Joachim Frank, and Charles L. Brooks, III

Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy
PNAS 2003 100: 9319-9323; published online before print July 23 2003, 10.1073/pnas.1632476100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cell Biology

Melike Lakadamyali, Michael J. Rust, Hazen P. Babcock, and Xiaowei Zhuang

Visualizing infection of individual influenza viruses
PNAS 2003 100: 9280-9285; published online before print July 25 2003, 10.1073/pnas.0832269100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ann M. Ranger, Jiping Zha, Hisashi Harada, Sandeep Robert Datta, Nika N. Danial, Andrew P. Gilmore, Jeffery L. Kutok, Michelle M. Le Beau, Michael E. Greenberg, and Stanley J. Korsmeyer

Bad-deficient mice develop diffuse large B cell lymphoma
PNAS 2003 100: 9324-9329; published online before print July 22 2003, 10.1073/pnas.1533446100 [Abstract] [Full Text] [PDF] [Supporting Infomation]  

Ulrik B. Nielsen, Mike H. Cardone, Anthony J. Sinskey, Gavin MacBeath, and Peter K. Sorger

Profiling receptor tyrosine kinase activation by using Ab microarrays
PNAS 2003 100: 9330-9335; published online before print July 22 2003, 10.1073/pnas.1633513100 [Abstract] [Full Text] [PDF]  

Federica Montanaro, Kalliopi Liadaki, Jay Volinski, Alan Flint, and Louis M. Kunkel

Skeletal muscle engraftment potential of adult mouse skin side population cells
PNAS 2003 100: 9336-9341; published online before print July 28 2003, 10.1073/pnas.1133179100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jun Zhang, Jinbo Yang, Sanjit K. Roy, Silvia Tininini, Jiadi Hu, Jacqueline F. Bromberg, Valeria Poli, George R. Stark, and Dhananjaya V. Kalvakolanu

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
PNAS 2003 100: 9342-9347; published online before print July 16 2003, 10.1073/pnas.1633516100 [Abstract] [Full Text] [PDF]  

Grégoy Y. Bédécarrats, Francis H. O'Neill, Errol R. Norwitz, Ursula B. Kaiser, and Jose Teixeira

Regulation of gonadotropin gene expression by Müllerian inhibiting substance
PNAS 2003 100: 9348-9353; published online before print July 23 2003, 10.1073/pnas.1633592100 [Abstract] [Full Text] [PDF]  

G. Fingerle-Rowson, O. Petrenko, C. N. Metz, T. G. Forsthuber, R. Mitchell, R. Huss, U. Moll, W. Müller, and R. Bucala

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
PNAS 2003 100: 9354-9359; published online before print July 23 2003, 10.1073/pnas.1533295100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Yuko Mori-Akiyama, Haruhiko Akiyama, David H. Rowitch, and Benoit de Crombrugghe

Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
PNAS 2003 100: 9360-9365; published online before print July 23 2003, 10.1073/pnas.1631288100 [Abstract] [Full Text] [PDF]  

Shijie Li, Da-Zhi Wang, Zhigao Wang, James A. Richardson, and Eric N. Olson

The serum response factor coactivator myocardin is required for vascular smooth muscle development
PNAS 2003 100: 9366-9370; published online before print July 16 2003, 10.1073/pnas.1233635100 [Abstract] [Full Text] [PDF]  

Hamid Bolouri and Eric H. Davidson

Transcriptional regulatory cascades in development: Initial rates, not steady state, determine network kinetics
PNAS 2003 100: 9371-9376; published online before print July 25 2003, 10.1073/pnas.1533293100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ecology

Carina Gjerdrum, Anne M. J. Vallée, Colleen Cassady St. Clair, Douglas F. Bertram, John L. Ryder, and Gwylim S. Blackburn

Tufted puffin reproduction reveals ocean climate variability
PNAS 2003 100: 9377-9382; published online before print July 18 2003, 10.1073/pnas.1133383100 [Abstract] [Full Text] [PDF]  

Jordi Bascompte, Pedro Jordano, Carlos J. Melián, and Jens M. Olesen

The nested assembly of plant–animal mutualistic networks
PNAS 2003 100: 9383-9387; published online before print July 24 2003, 10.1073/pnas.1633576100 [Abstract] [Full Text] [PDF]  

Evolution

Rosario Gil, Francisco J. Silva, Evelyn Zientz, François Delmotte, Fernando González-Candelas, Amparo Latorre, Carolina Rausell, Judith Kamerbeek, Jürgen Gadau, Bert Hölldobler, Roeland C. H. J. van Ham, Roy Gross, and Andrés Moya

The genome sequence of Blochmannia floridanus: Comparative analysis of reduced genomes
PNAS 2003 100: 9388-9393; published online before print July 28 2003, 10.1073/pnas.1533499100 [Abstract] [Full Text] [PDF] [Supporting Information]  

William O. H. Hughes, Seirian Sumner, Steven Van Borm, and Jacobus J. Boomsma

Worker caste polymorphism has a genetic basis in Acromyrmex leaf-cutting ants
PNAS 2003 100: 9394-9397; published online before print July 23 2003, 10.1073/pnas.1633701100 [Abstract] [Full Text] [PDF]  

Elena Cherkasova, Majid Laassri, Vladimir Chizhikov, Ekaterina Korotkova, Eugenia Dragunsky, Vadim I. Agol, and Konstantin Chumakov

Microarray analysis of evolution of RNA viruses: Evidence of circulation of virulent highly divergent vaccine-derived polioviruses
PNAS 2003 100: 9398-9403; published online before print July 23 2003, 10.1073/pnas.1633511100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Philip L. Reno, Richard S. Meindl, Melanie A. McCollum, and C. Owen Lovejoy Sexual dimorphism in Australopithecus afarensis was similar to that of modern humans PNAS 2003 100: 9404-9409; published online before print July 23 2003, 10.1073/pnas.1133180100 [Abstract] [Full Text] [PDF] [Supporting Information]   See Commentary on page 9103

Genetics

Lisa M. Goering, Kazuyuki Hoshijima, Barbara Hug, Brent Bisgrove, Andreas Kispert, and David Jonah Grunwald

An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm
PNAS 2003 100: 9410-9415; published online before print July 25 2003, 10.1073/pnas.1633548100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Hirotaka Kawano, Takashi Sato, Takashi Yamada, Takahiro Matsumoto, Keisuke Sekine, Tomoyuki Watanabe, Takashi Nakamura, Toru Fukuda, Kimihiro Yoshimura, Tatsuya Yoshizawa, Ken-ichi Aihara, Yoko Yamamoto, Yuko Nakamichi, Daniel Metzger, Pierre Chambon, Kozo Nakamura, Hiroshi Kawaguchi, and Shigeaki Kato

Suppressive function of androgen receptor in bone resorption
PNAS 2003 100: 9416-9421; published online before print July 18 2003, 10.1073/pnas.1533500100 [Abstract] [Full Text] [PDF]  

Zbigniew Dominski, Xiao-cui Yang, Matthew Purdy, and William F. Marzluff

Cloning and characterization of the Drosophila U7 small nuclear RNA
PNAS 2003 100: 9422-9427; published online before print July 18 2003, 10.1073/pnas.1533509100 [Abstract] [Full Text] [PDF]  

Ling V. Sun, Liang Chen, Frauke Greil, Nicolas Negre, Tong-Ruei Li, Giacomo Cavalli, Hongyu Zhao, Bas van Steensel, and Kevin P. White

Protein–DNA interaction mapping using genomic tiling path microarrays in Drosophila
PNAS 2003 100: 9428-9433; published online before print July 22 2003, 10.1073/pnas.1533393100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Y. Kate Hong, Aki Mikami, Brian Schaffhausen, Toni Jun, and Thomas M. Roberts

A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site
PNAS 2003 100: 9434-9439; published online before print July 24 2003, 10.1073/pnas.1432964100 [Abstract] [Full Text] [PDF] [Supporting Text]  

John D. Storey and Robert Tibshirani

Statistical significance for genomewide studies
PNAS 2003 100: 9440-9445; published online before print July 25 2003, 10.1073/pnas.1530509100 [Abstract] [Full Text] [PDF]  

Immunology

Constanze Breithaupt, Anna Schubart, Hilke Zander, Arne Skerra, Robert Huber, Christopher Linington, and Uwe Jacob

Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein
PNAS 2003 100: 9446-9451; published online before print July 21 2003, 10.1073/pnas.1133443100 [Abstract] [Full Text] [PDF]  

Veronika Groh, Anja Brühl, Hani El-Gabalawy, J. Lee Nelson, and Thomas Spies

Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis
PNAS 2003 100: 9452-9457; published online before print July 23 2003, 10.1073/pnas.1632807100 [Abstract] [Full Text] [PDF]  

Igor M. Belyakov, Patricia Earl, Amiran Dzutsev, Vladimir A. Kuznetsov, Michael Lemon, Linda S. Wyatt, James T. Snyder, Jeffrey D. Ahlers, Genoveffa Franchini, Bernard Moss, and Jay A. Berzofsky

Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses
PNAS 2003 100: 9458-9463; published online before print July 17 2003, 10.1073/pnas.1233578100 [Abstract] [Full Text] [PDF]  

Yoshihiro Hayakawa, Stefania Rovero, Guido Forni, and Mark J. Smyth

-Galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis
PNAS 2003 100: 9464-9469; published online before print July 16 2003, 10.1073/pnas.1630663100 [Abstract] [Full Text] [PDF]  

Yuko Kawakami, Jiro Kitaura, Libo Yao, Robert W. McHenry, Yu Kawakami, Alexandra C. Newton, Shin Kang, Roberta M. Kato, Michael Leitges, David J. Rawlings, and Toshiaki Kawakami

A Ras activation pathway dependent on Syk phosphorylation of protein kinase C
PNAS 2003 100: 9470-9475; published online before print July 24 2003, 10.1073/pnas.1633695100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Medical Sciences

Jinping Li, Kiyosumi Takaishi, William Cook, Sara Kay McCorkle, and Roger H. Unger

Insig-1 "brakes" lipogenesis in adipocytes and inhibits differentiation of preadipocytes
PNAS 2003 100: 9476-9481; published online before print July 17 2003, 10.1073/pnas.1133426100 [Abstract] [Full Text] [PDF]  

Melanie Rolli, Emilia Fransvea, Jan Pilch, Alan Saven, and Brunhilde Felding-Habermann

Activated integrin v3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
PNAS 2003 100: 9482-9487; published online before print July 21 2003, 10.1073/pnas.1633689100 [Abstract] [Full Text] [PDF]  

Sébastien Bonnet, Eric Dumas-de-La-Roque, Hugues Bégueret, Roger Marthan, Michael Fayon, Pierre Dos Santos, Jean-Pierre Savineau, and Etienne-Emile Baulieu

Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension
PNAS 2003 100: 9488-9493; published online before print July 23 2003, 10.1073/pnas.1633724100 [Abstract] [Full Text] [PDF]  

Yuichi Oike, Kunio Yasunaga, Yasuhiro Ito, Shun-ichiro Matsumoto, Hiromitsu Maekawa, Tohru Morisada, Fumio Arai, Naomi Nakagata, Motohiro Takeya, Yasuhiko Masuho, and Toshio Suda

Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration
PNAS 2003 100: 9494-9499; published online before print July 18 2003, 10.1073/pnas.1531901100 [Abstract] [Full Text] [PDF] [Supporting Information]  

An-Sheng Zhang, Paige S. Davies, Hanqian L. Carlson, and Caroline A. Enns

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation
PNAS 2003 100: 9500-9505; published online before print July 21 2003, 10.1073/pnas.1233675100 [Abstract] [Full Text] [PDF]  

Jay L. Grisolano, Julie O'Neal, Jennifer Cain, and Michael H. Tomasson

An activated receptor tyrosine kinase, TEL/PDGFR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice
PNAS 2003 100: 9506-9511; published online before print July 24 2003, 10.1073/pnas.1531730100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Hippokratis Kiaris, Ioulia Chatzistamou, Andrew V. Schally, Gabor Halmos, Jozsef L. Varga, Helen Koutselini, and Anastasios Kalofoutis

Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor
PNAS 2003 100: 9512-9517; published online before print July 16 2003, 10.1073/pnas.1533185100 [Abstract] [Full Text] [PDF]  

Jennifer C. Condon, Pancharatnam Jeyasuria, Julie M. Faust, James W. Wilson, and Carole R. Mendelson

A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition
PNAS 2003 100: 9518-9523; published online before print July 28 2003, 10.1073/pnas.1633616100 [Abstract] [Full Text] [PDF]  

Sudhakar Baluchamy, Hasan N. Rajabi, Rama Thimmapaya, Arunasalam Navaraj, and Bayar Thimmapaya

Repression of c-Myc and inhibition of G₁ exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity
PNAS 2003 100: 9524-9529; published online before print July 25 2003, 10.1073/pnas.1633700100 [Abstract] [Full Text] [PDF]  

Xiaodi Chen, Richard B. Halberg, William M. Ehrhardt, Jose Torrealba, and William F. Dove

Clusterin as a biomarker in murine and human intestinal neoplasia
PNAS 2003 100: 9530-9535; published online before print July 28 2003, 10.1073/pnas.1233633100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Microbiology

Gerald F. Späth, L. A. Garraway, Salvatore J. Turco, and Stephen M. Beverley

The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts
PNAS 2003 100: 9536-9541; published online before print July 17 2003, 10.1073/pnas.1530604100 [Abstract] [Full Text] [PDF]  

Renata Grifantini, Shite Sebastian, Elisabetta Frigimelica, Monia Draghi, Erika Bartolini, Alessandro Muzzi, Rino Rappuoli, Guido Grandi, and Caroline Attardo Genco

Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B
PNAS 2003 100: 9542-9547; published online before print July 25 2003, 10.1073/pnas.1033001100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Dulal Panda, Jonathan C. Samuel, Michelle Massie, Stuart C. Feinstein, and Leslie Wilson

Differential regulation of microtubule dynamics by three- and four-repeat tau: Implications for the onset of neurodegenerative disease
PNAS 2003 100: 9548-9553; published online before print July 28 2003, 10.1073/pnas.1633508100 [Abstract] [Full Text] [PDF]  

Ghanashyam D. Ghadge, Barbara S. Slusher, Amos Bodner, Mauro Dal Canto, Krystyna Wozniak, Ajit G. Thomas, Camilo Rojas, Takashi Tsukamoto, Pavel Majer, Richard J. Miller, Anna Liza Monti, and Raymond P. Roos

Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models
PNAS 2003 100: 9554-9559; published online before print July 22 2003, 10.1073/pnas.1530168100 [Abstract] [Full Text] [PDF]  

Ji Ying Sze and Gary Ruvkun

Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity
PNAS 2003 100: 9560-9565; published online before print July 25 2003, 10.1073/pnas.1530752100 [Abstract] [Full Text] [PDF]  

Michael A. Packer, Yuri Stasiv, Abdellatif Benraiss, Eva Chmielnicki, Alexander Grinberg, Heiner Westphal, Steven A. Goldman, and Grigori Enikolopov

Nitric oxide negatively regulates mammalian adult neurogenesis
PNAS 2003 100: 9566-9571; published online before print July 28 2003, 10.1073/pnas.1633579100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Jorge J. Palop, Brian Jones, Lisa Kekonius, Jeannie Chin, Gui-Qiu Yu, Jacob Raber, Eliezer Masliah, and Lennart Mucke

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
PNAS 2003 100: 9572-9577; published online before print July 24 2003, 10.1073/pnas.1133381100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Edoardo Marcora, Katherine Gowan, and Jacqueline E. Lee

Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2
PNAS 2003 100: 9578-9583; published online before print July 24 2003, 10.1073/pnas.1133382100 [Abstract] [Full Text] [PDF]  

Daiichiro Nakahara, Masato Nakamura, Masayuki Iigo, and Hitoshi Okamura

Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse
PNAS 2003 100: 9584-9589; published online before print July 21 2003, 10.1073/pnas.1631069100 [Abstract] [Full Text] [PDF]  

Sukkid Yasothornsrikul, Doron Greenbaum, Katalin F. Medzihradszky, Thomas Toneff, Richard Bundey, Ruthellen Miller, Birgit Schilling, Ivonne Petermann, Jessica Dehnert, Anna Logvinova, Paul Goldsmith, John M. Neveu, William S. Lane, Bradford Gibson, Thomas Reinheckel, Christoph Peters, Matthew Bogyo, and Vivian Hook

Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
PNAS 2003 100: 9590-9595; published online before print July 17 2003, 10.1073/pnas.1531542100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Sylvie Granon, Philippe Faure, and Jean-Pierre Changeux

Executive and social behaviors under nicotinic receptor regulation
PNAS 2003 100: 9596-9601; published online before print July 22 2003, 10.1073/pnas.1533498100 [Abstract] [Full Text] [PDF]  

Martin Theis, Kausik Si, and Eric R. Kandel

Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus
PNAS 2003 100: 9602-9607; published online before print July 18 2003, 10.1073/pnas.1133424100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Pharmacology

Erik C. Gunther, David J. Stone, Robert W. Gerwien, Patricia Bento, and Melvyn P. Heyes

Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro
PNAS 2003 100: 9608-9613; published online before print July 17 2003, 10.1073/pnas.1632587100 [Abstract] [Full Text] [PDF]  

Elisabetta Vegeto, Silvia Belcredito, Sabrina Etteri, Serena Ghisletti, Alessia Brusadelli, Clara Meda, Andrée Krust, Sonia Dupont, Paolo Ciana, Pierre Chambon, and Adriana Maggi

Estrogen receptor- mediates the brain antiinflammatory activity of estradiol
PNAS 2003 100: 9614-9619; published online before print July 23 2003, 10.1073/pnas.1531957100 [Abstract] [Full Text] [PDF]  

Physiology

Viswanathan Raghuram, Hayley Hormuth, and J. Kevin Foskett

A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions
PNAS 2003 100: 9620-9625; published online before print July 24 2003, 10.1073/pnas.1633250100 [Abstract] [Full Text] [PDF]  

Plant Biology

Uwe Schumann, Gerhard Wanner, Marten Veenhuis, Markus Schmid, and Christine Gietl

AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis
PNAS 2003 100: 9626-9631; published online before print July 25 2003, 10.1073/pnas.1633697100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ramachandran Vanitharani, Padmanabhan Chellappan, and Claude M. Fauquet

Short interfering RNA-mediated interference of gene expression and viral DNA accumulation in cultured plant cells
PNAS 2003 100: 9632-9636; published online before print July 28 2003, 10.1073/pnas.1733874100 [Abstract] [Full Text] [PDF]