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Table of Contents

September 2, 2003; 100 (18)  [Index By Author]  [Cover Photo]

FROM THE COVER

Myocardial regeneration by putative stem cells

Carbon nanotubes: Slippery when wet

Streams dampen ecosystem disruption

Tracking climate change with genetics

How dismutase gets its manganese

COMMENTARIES

PHYSICAL SCIENCES
    Applied Mathematics
    Applied Physical Sciences
    Chemistry
    Physics

SOCIAL SCIENCES
    Psychology
    Social Sciences

BIOLOGICAL SCIENCES
    Agricultural Sciences
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Ecology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Physiology
    Plant Biology
    Population Biology

CORRECTIONS

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COMMENTARIES

Robert O. Hall, Jr.
A stream's role in watershed nutrient export
PNAS 2003 100: 10137-10138; published online before print August 26 2003, 10.1073/pnas.1934477100 [Extract] [Full Text] [PDF]  
See companion article on page 10304

Thomas M. Truskett
The subtleties of water in small spaces
PNAS 2003 100: 10139-10140; published online before print August 26 2003, 10.1073/pnas.1934641100 [Extract] [Full Text] [PDF]  
See companion article on page 10175

F. Archibald
Oxygen toxicity and the health and survival of eukaryote cells: A new piece is added to the puzzle
PNAS 2003 100: 10141-10143; published online before print August 25 2003, 10.1073/pnas.1934513100 [Extract] [Full Text] [PDF]  
See companion article on page 10353

Harry Klee
Hormones are in the air
PNAS 2003 100: 10144-10145; published online before print August 26 2003, 10.1073/pnas.1934350100 [Extract] [Full Text] [PDF]  
See companion article on page 10552

PHYSICAL SCIENCES

Applied Mathematics

Ziv Bar-Joseph, Georg Gerber, Itamar Simon, David K. Gifford, and Tommi S. Jaakkola
Comparing the continuous representation of time-series expression profiles to identify differentially expressed genes
PNAS 2003 100: 10146-10151; published online before print August 21 2003, 10.1073/pnas.1732547100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Robert Dillon, Chetan Gadgil, and Hans G. Othmer
Short- and long-range effects of Sonic hedgehog in limb development
PNAS 2003 100: 10152-10157; published online before print August 20 2003, 10.1073/pnas.1830500100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chris T. Bauch, Alison P. Galvani, and David J. D. Earn
Group interest versus self-interest in smallpox vaccination policy
PNAS 2003 100: 10564-10567; published online before print August 14 2003, 10.1073/pnas.1731324100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Applied Physical Sciences

Jan H. Ardenkjær-Larsen, Björn Fridlund, Andreas Gram, Georg Hansson, Lennart Hansson, Mathilde H. Lerche, Rolf Servin, Mikkel Thaning, and Klaes Golman
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR
PNAS 2003 100: 10158-10163; published online before print August 20 2003, 10.1073/pnas.1733835100 [Abstract] [Full Text] [PDF]  

Folim G. Halaka
Dielectrophoretic dynamic light-scattering (DDLS) spectroscopy
PNAS 2003 100: 10164-10169; published online before print August 18 2003, 10.1073/pnas.1233790100 [Abstract] [Full Text] [PDF]  

Chemistry

K. Peter R. Nilsson, Johan Rydberg, Lars Baltzer, and Olle Inganäs
Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative
PNAS 2003 100: 10170-10174; published online before print August 19 2003, 10.1073/pnas.1834422100 [Abstract] [Full Text] [PDF]  

Physics

Amrit Kalra, Shekhar Garde, and Gerhard Hummer
From The Cover: Osmotic water transport through carbon nanotube membranes
PNAS 2003 100: 10175-10180; published online before print July 23 2003, 10.1073/pnas.1633354100 [Abstract] [Full Text] [PDF]  
See Commentary on page 10139

SOCIAL SCIENCES

Psychology

Scott P. Johnson, Dima Amso, and Jonathan A. Slemmer
Development of object concepts in infancy: Evidence for early learning in an eye-tracking paradigm
PNAS 2003 100: 10568-10573; published online before print August 25 2003, 10.1073/pnas.1630655100 [Abstract] [Full Text] [PDF]  

Social Sciences

Florence J. Dallo and Susan C. Weller
Effectiveness of diabetes mellitus screening recommendations
PNAS 2003 100: 10574-10579; published online before print August 18 2003, 10.1073/pnas.1733839100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

C. Robin Buell, Vinita Joardar, Magdalen Lindeberg, Jeremy Selengut, Ian T. Paulsen, Michelle L. Gwinn, Robert J. Dodson, Robert T. Deboy, A. Scott Durkin, James F. Kolonay, Ramana Madupu, Sean Daugherty, Lauren Brinkac, Maureen J. Beanan, Daniel H. Haft, William C. Nelson, Tanja Davidsen, Nikhat Zafar, Liwei Zhou, Jia Liu, Qiaoping Yuan, Hoda Khouri, Nadia Fedorova, Bao Tran, Daniel Russell, Kristi Berry, Teresa Utterback, Susan E. Van Aken, Tamara V. Feldblyum, Mark D'Ascenzo, Wen-Ling Deng, Adela R. Ramos, James R. Alfano, Samuel Cartinhour, Arun K. Chatterjee, Terrence P. Delaney, Sondra G. Lazarowitz, Gregory B. Martin, David J. Schneider, Xiaoyan Tang, Carol L. Bender, Owen White, Claire M. Fraser, and Alan Collmer
The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000
PNAS 2003 100: 10181-10186; published online before print August 19 2003, 10.1073/pnas.1731982100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biochemistry

Natalia Ermolova, Lan Guan, and H. Ronald Kaback
Intermolecular thiol cross-linking via loops in the lactose permease of Escherichia coli
PNAS 2003 100: 10187-10192; published online before print August 21 2003, 10.1073/pnas.1434239100 [Abstract] [Full Text] [PDF]  

Oriano Marin, Victor H. Bustos, Luca Cesaro, Flavio Meggio, Mario A. Pagano, Marcelo Antonelli, Catherine C. Allende, Lorenzo A. Pinna, and Jorge E. Allende
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: A noncanonical sequence phosphorylated by casein kinase 1 in {beta}-catenin may play a role in casein kinase 1 targeting of important signaling proteins
PNAS 2003 100: 10193-10200; published online before print August 18 2003, 10.1073/pnas.1733909100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Amitabh V. Nimonkar and Paul E. Boehmer
Reconstitution of recombination-dependent DNA synthesis in herpes simplex virus 1
PNAS 2003 100: 10201-10206; published online before print August 19 2003, 10.1073/pnas.1534569100 [Abstract] [Full Text] [PDF]  

Lutfi Abu-Elheiga, Wonkeun Oh, Parichher Kordari, and Salih J. Wakil
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
PNAS 2003 100: 10207-10212; published online before print August 14 2003, 10.1073/pnas.1733877100 [Abstract] [Full Text] [PDF]  

David B. Hicks, ZhenXiong Wang, Yi Wei, Rebecca Kent, Arthur A. Guffanti, Horia Banciu, David H. Bechhofer, and Terry A. Krulwich
A tenth atp gene and the conserved atpI gene of a Bacillus atp operon have a role in Mg2+ uptake
PNAS 2003 100: 10213-10218; published online before print August 13 2003, 10.1073/pnas.1832982100 [Abstract] [Full Text] [PDF]  

Çagla Eroglu, Britta Brügger, Felix Wieland, and Irmgard Sinning
Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts
PNAS 2003 100: 10219-10224; published online before print August 15 2003, 10.1073/pnas.1737042100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yukako Chiba, Ryoko Sakurai, Michiko Yoshino, Kimihiro Ominato, Mari Ishikawa, Hitoshi Onouchi, and Satoshi Naito
S-adenosyl-L-methionine is an effector in the posttranscriptional autoregulation of the cystathionine {gamma}-synthase gene in Arabidopsis
PNAS 2003 100: 10225-10230; published online before print August 21 2003, 10.1073/pnas.1831512100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Takumi Kamura, Taichi Hara, Shuhei Kotoshiba, Masayoshi Yada, Noriko Ishida, Hiroyuki Imaki, Shigetsugu Hatakeyama, Keiko Nakayama, and Keiichi I. Nakayama
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation
PNAS 2003 100: 10231-10236; published online before print August 18 2003, 10.1073/pnas.1831009100 [Abstract] [Full Text] [PDF]  

Vladimir P. Bermudez, Yoshimasa Maniwa, Inger Tappin, Keiko Ozato, Kyoko Yokomori, and Jerard Hurwitz
The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA
PNAS 2003 100: 10237-10242; published online before print August 20 2003, 10.1073/pnas.1434308100 [Abstract] [Full Text] [PDF]  

Changbong Hyeon and D. Thirumalai
Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?
PNAS 2003 100: 10249-10253; published online before print August 21 2003, 10.1073/pnas.1833310100 [Abstract] [Full Text] [PDF]  

Biophysics

Niklas Engler, Andreas Ostermann, Nobuo Niimura, and Fritz G. Parak
Hydrogen atoms in proteins: Positions and dynamics
PNAS 2003 100: 10243-10248; published online before print August 22 2003, 10.1073/pnas.1834279100 [Abstract] [Full Text] [PDF]  

Changbong Hyeon and D. Thirumalai
Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?
PNAS 2003 100: 10249-10253; published online before print August 21 2003, 10.1073/pnas.1833310100 [Abstract] [Full Text] [PDF]  

Aleksey Lomakin, Neer Asherie, and George B. Benedek
Liquid-solid transition in nuclei of protein crystals
PNAS 2003 100: 10254-10257; published online before print August 18 2003, 10.1073/pnas.1334069100 [Abstract] [Full Text] [PDF]  

Céline Valéry, Maïté Paternostre, Bruno Robert, Thaddée Gulik-Krzywicki, Theyencheri Narayanan, Jean-Claude Dedieu, Gérard Keller, Maria-Luisa Torres, Roland Cherif-Cheikh, Pilar Calvo, and Franck Artzner
Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension
PNAS 2003 100: 10258-10262; published online before print August 20 2003, 10.1073/pnas.1730609100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Cell Biology

Gaia Tavosanis and Cayetano Gonzalez
{gamma}-Tubulin function during female germ-cell development and oogenesis in Drosophila
PNAS 2003 100: 10263-10268; published online before print August 12 2003, 10.1073/pnas.1731925100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yaw-Ching Yang, Ester Piek, Jiri Zavadil, Dan Liang, Donglu Xie, Joerg Heyer, Paul Pavlidis, Raju Kucherlapati, Anita B. Roberts, and Erwin P. Böttinger
Hierarchical model of gene regulation by transforming growth factor {beta}
PNAS 2003 100: 10269-10274; published online before print August 20 2003, 10.1073/pnas.1834070100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tracy L. Laabs, David D. Markwardt, Matthew G. Slattery, Laura L. Newcomb, David J. Stillman, and Warren Heideman
ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae
PNAS 2003 100: 10275-10280; published online before print August 22 2003, 10.1073/pnas.1833999100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tony Truong, Guizhen Sun, Michael Doorly, Jean Y. J. Wang, and Martin Alexander Schwartz
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
PNAS 2003 100: 10281-10286; published online before print August 19 2003, 10.1073/pnas.1635435100 [Abstract] [Full Text] [PDF]  

Raphael H. Valdivia and Randy Schekman
The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane
PNAS 2003 100: 10287-10292; published online before print August 19 2003, 10.1073/pnas.1834246100 [Abstract] [Full Text] [PDF]  

Developmental Biology

P. D. Si Dong, Sokol V. Todi, Daniel F. Eberl, and Grace Boekhoff-Falk
Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes
PNAS 2003 100: 10293-10298; published online before print August 18 2003, 10.1073/pnas.1836391100 [Abstract] [Full Text] [PDF]  

Elena Levantini, Alessandra Giorgetti, Francesco Cerisoli, Elisabetta Traggiai, Alessandra Guidi, Richard Martin, Dario Acampora, Peter D. Aplan, Gordon Keller, Antonio Simeone, Norman N. Iscove, Trang Hoang, and Maria Cristina Magli
Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis
PNAS 2003 100: 10299-10303; published online before print August 21 2003, 10.1073/pnas.1734071100 [Abstract] [Full Text] [PDF]  

Ecology

E. S. Bernhardt, G. E. Likens, D. C. Buso, and C. T. Driscoll
From The Cover: In-stream uptake dampens effects of major forest disturbance on watershed nitrogen export
PNAS 2003 100: 10304-10308; published online before print July 25 2003, 10.1073/pnas.1233676100 [Abstract] [Full Text] [PDF]  
See Commentary on page 10137

R. A. Mittermeier, C. G. Mittermeier, T. M. Brooks, J. D. Pilgrim, W. R. Konstant, G. A. B. da Fonseca, and C. Kormos
Wilderness and biodiversity conservation
PNAS 2003 100: 10309-10313; published online before print August 20 2003, 10.1073/pnas.1732458100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Evolution

Jeffrey L. Feder, Stewart H. Berlocher, Joseph B. Roethele, Hattie Dambroski, James J. Smith, William L. Perry, Vesna Gavrilovic, Kenneth E. Filchak, Juan Rull, and Martin Aluja
Allopatric genetic origins for sympatric host-plant shifts and race formation in Rhagoletis
PNAS 2003 100: 10314-10319; published online before print August 19 2003, 10.1073/pnas.1730757100 [Abstract] [Full Text] [PDF]  

Rhoda J. Kinsella, David A. Fitzpatrick, Christopher J. Creevey, and James O. McInerney
Fatty acid biosynthesis in Mycobacterium tuberculosis: Lateral gene transfer, adaptive evolution, and gene duplication
PNAS 2003 100: 10320-10325; published online before print August 13 2003, 10.1073/pnas.1737230100 [Abstract] [Full Text] [PDF] [Supporting Information]  

R. N. Hughes, P. H. Manríquez, J. D. D. Bishop, and M. T. Burrows
Stress promotes maleness in hermaphroditic modular animals
PNAS 2003 100: 10326-10330; published online before print August 20 2003, 10.1073/pnas.1334011100 [Abstract] [Full Text] [PDF]  

Enrique P. Lessa, Joseph A. Cook, and James L. Patton
From The Cover: Genetic footprints of demographic expansion in North America, but not Amazonia, during the Late Quaternary
PNAS 2003 100: 10331-10334; published online before print August 11 2003, 10.1073/pnas.1730921100 [Abstract] [Full Text] [PDF]  

Gwenaël Piganeau and Adam Eyre-Walker
Estimating the distribution of fitness effects from DNA sequence data: Implications for the molecular clock
PNAS 2003 100: 10335-10340; published online before print August 18 2003, 10.1073/pnas.1833064100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Vincent Dietemann, Christian Peeters, Jürgen Liebig, Virginie Thivet, and Bert Hölldobler
Cuticular hydrocarbons mediate discrimination of reproductives and nonreproductives in the ant Myrmecia gulosa
PNAS 2003 100: 10341-10346; published online before print August 14 2003, 10.1073/pnas.1834281100 [Abstract] [Full Text] [PDF]  

Genetics

Ziv Bar-Joseph, Georg Gerber, Itamar Simon, David K. Gifford, and Tommi S. Jaakkola
Comparing the continuous representation of time-series expression profiles to identify differentially expressed genes
PNAS 2003 100: 10146-10151; published online before print August 21 2003, 10.1073/pnas.1732547100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Dagmar Nolte, Stephan Niemann, and Ulrich Müller
Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism
PNAS 2003 100: 10347-10352; published online before print August 19 2003, 10.1073/pnas.1831949100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Edward Luk, Mark Carroll, Michelle Baker, and Valeria Cizewski Culotta
From The Cover: Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family
PNAS 2003 100: 10353-10357; published online before print July 30 2003, 10.1073/pnas.1632471100 [Abstract] [Full Text] [PDF] [Supporting Table]  
See Commentary on page 10141

Dashzeveg Bayarsaihan, Badam Enkhmandakh, Aleksandr Makeyev, John M. Greally, James F. Leckman, and Frank H. Ruddle
Homez, a homeobox leucine zipper gene specific to the vertebrate lineage
PNAS 2003 100: 10358-10363; published online before print August 18 2003, 10.1073/pnas.1834010100 [Abstract] [Full Text] [PDF]  

Stephen N. White, Kristen H. Taylor, Colette A. Abbey, Clare A. Gill, and James E. Womack
Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain
PNAS 2003 100: 10364-10369; published online before print August 12 2003, 10.1073/pnas.1333957100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Peng Lu, Aleksey Nakorchevskiy, and Edward M. Marcotte
Expression deconvolution: A reinterpretation of DNA microarray data reveals dynamic changes in cell populations
PNAS 2003 100: 10370-10375; published online before print August 21 2003, 10.1073/pnas.1832361100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Immunology

Hiroaki Moriyama, Norio Abiru, Johanna Paronen, Kamila Sikora, Edwin Liu, Dongmei Miao, Devasenan Devendra, Joshua Beilke, Roberto Gianani, Ron G. Gill, and George S. Eisenbarth
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse
PNAS 2003 100: 10376-10381; published online before print August 18 2003, 10.1073/pnas.1834450100 [Abstract] [Full Text] [PDF]  

Malini Pandarpurkar, Leanne Wilson-Fritch, Silvia Corvera, Helle Markholst, Lars Hornum, Dale L. Greiner, John P. Mordes, Aldo A. Rossini, and Rita Bortell
Ian4 is required for mitochondrial integrity and T cell survival
PNAS 2003 100: 10382-10387; published online before print August 20 2003, 10.1073/pnas.1832170100 [Abstract] [Full Text] [PDF]  

Xingxing Zang, P'ng Loke, Jayon Kim, Kenneth Murphy, Rebecca Waitz, and James P. Allison
B7x: A widely expressed B7 family member that inhibits T cell activation
PNAS 2003 100: 10388-10392; published online before print August 14 2003, 10.1073/pnas.1434299100 [Abstract] [Full Text] [PDF]  

Medical Sciences

Christos Sotiriou, Soek-Ying Neo, Lisa M. McShane, Edward L. Korn, Philip M. Long, Amir Jazaeri, Philippe Martiat, Steve B. Fox, Adrian L. Harris, and Edison T. Liu
Breast cancer classification and prognosis based on gene expression profiles from a population-based study
PNAS 2003 100: 10393-10398; published online before print August 13 2003, 10.1073/pnas.1732912100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Richard G. Jenner, Karine Maillard, Nicola Cattini, Robin A. Weiss, Chris Boshoff, Richard Wooster, and Paul Kellam
Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
PNAS 2003 100: 10399-10404; published online before print August 18 2003, 10.1073/pnas.1630810100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Simone Cenci, Gianluca Toraldo, M. Neale Weitzmann, Cristiana Roggia, Yuhao Gao, Wei Ping Qian, Oscar Sierra, and Roberto Pacifici
Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-{gamma}-induced class II transactivator
PNAS 2003 100: 10405-10410; published online before print August 15 2003, 10.1073/pnas.1533207100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

A. Heredia, A. Amoroso, C. Davis, N. Le, E. Reardon, J. K. Dominique, E. Klingebiel, R. C. Gallo, and R. R. Redfield
Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV {beta}-chemokines: An approach to suppress R5 strains of HIV-1
PNAS 2003 100: 10411-10416; published online before print August 12 2003, 10.1073/pnas.1834278100 [Abstract] [Full Text] [PDF]  

Yuesong Gong, Lei Chang, Kirsten L. Viola, Pascale N. Lacor, Mary P Lambert, Caleb E. Finch, Grant A. Krafft, and William L. Klein
Alzheimer's disease-affected brain: Presence of oligomeric A{beta} ligands (ADDLs) suggests a molecular basis for reversible memory loss
PNAS 2003 100: 10417-10422; published online before print August 18 2003, 10.1073/pnas.1834302100 [Abstract] [Full Text] [PDF]  

Bo Feng, Dajun Zhang, George Kuriakose, Cecillia M. Devlin, Mark Kockx, and Ira Tabas
Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis
PNAS 2003 100: 10423-10428; published online before print August 15 2003, 10.1073/pnas.1732494100 [Abstract] [Full Text] [PDF]  

Tatsuo Ohira, Robert M. Gemmill, Kevin Ferguson, Sophie Kusy, Joëlle Roche, Elisabeth Brambilla, Chan Zeng, Anna Baron, Lynne Bemis, Paul Erickson, Elizabeth Wilder, Anil Rustgi, Jan Kitajewski, Edward Gabrielson, Roy Bremnes, Wilbur Franklin, and Harry A. Drabkin
WNT7a induces E-cadherin in lung cancer cells
PNAS 2003 100: 10429-10434; published online before print August 22 2003, 10.1073/pnas.1734137100 [Abstract] [Full Text] [PDF]  

Klaes Golman, Jan H. Ardenkjær-Larsen, J. Stefan Petersson, Sven Månsson, and Ib Leunbach
Molecular imaging with endogenous substances
PNAS 2003 100: 10435-10439; published online before print August 20 2003, 10.1073/pnas.1733836100 [Abstract] [Full Text] [PDF]  

Konrad Urbanek, Federico Quaini, Giordano Tasca, Daniele Torella, Clotilde Castaldo, Bernardo Nadal-Ginard, Annarosa Leri, Jan Kajstura, Eugenio Quaini, and Piero Anversa
From The Cover: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
PNAS 2003 100: 10440-10445; published online before print August 19 2003, 10.1073/pnas.1832855100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Michael J. Coyne, Katja G. Weinacht, Corinna M. Krinos, and Laurie E. Comstock
Mpi recombinase globally modulates the surface architecture of a human commensal bacterium
PNAS 2003 100: 10446-10451; published online before print August 12 2003, 10.1073/pnas.1832655100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jian Xu and Jeffrey I. Gordon
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Honor thy symbionts
PNAS 2003 100: 10452-10459; published online before print August 15 2003, 10.1073/pnas.1734063100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Roy A. Hall, Debra J. Nisbet, Kim B. Pham, Alyssa T. Pyke, Greg A. Smith, and Alexander A. Khromykh
DNA vaccine coding for the full-length infectious Kunjin virus RNA protects mice against the New York strain of West Nile virus
PNAS 2003 100: 10460-10464; published online before print August 13 2003, 10.1073/pnas.1834270100 [Abstract] [Full Text] [PDF]  

Matxalen Llosa, Sandra Zunzunegui, and Fernando de la Cruz
Conjugative coupling proteins interact with cognate and heterologous VirB10-like proteins while exhibiting specificity for cognate relaxosomes
PNAS 2003 100: 10465-10470; published online before print August 18 2003, 10.1073/pnas.1830264100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Federico Katzen and Jon Beckwith
Role and location of the unusual redox-active cysteines in the hydrophobic domain of the transmembrane electron transporter DsbD
PNAS 2003 100: 10471-10476; published online before print August 18 2003, 10.1073/pnas.1334136100 [Abstract] [Full Text] [PDF]  

Laura R. Chromy, James M. Pipas, and Robert L. Garcea
Chaperone-mediated in vitro assembly of Polyomavirus capsids
PNAS 2003 100: 10477-10482; published online before print August 19 2003, 10.1073/pnas.1832245100 [Abstract] [Full Text] [PDF]  

Neuroscience

Xin Wang, Shan Zhu, Martin Drozda, Wenhua Zhang, Irina G. Stavrovskaya, Elena Cattaneo, Robert J. Ferrante, Bruce S. Kristal, and Robert M. Friedlander
Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
PNAS 2003 100: 10483-10487; published online before print August 20 2003, 10.1073/pnas.1832501100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Lei Hu, Jingyi Shi, Zhongming Ma, Gayathri Krishnamoorthy, Fred Sieling, Guangping Zhang, Frank T. Horrigan, and Jianmin Cui
Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels
PNAS 2003 100: 10488-10493; published online before print August 18 2003, 10.1073/pnas.1834300100 [Abstract] [Full Text] [PDF]  

Thomas Deller, Martin Korte, Sophie Chabanis, Alexander Drakew, Herbert Schwegler, Giulia Good Stefani, Aimee Zuniga, Karin Schwarz, Tobias Bonhoeffer, Rolf Zeller, Michael Frotscher, and Peter Mundel
Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity
PNAS 2003 100: 10494-10499; published online before print August 19 2003, 10.1073/pnas.1832384100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

L. Weiskrantz, A. Rao, I. Hodinott-Hill, A. C. Nobre, and A. Cowey
Brain potentials associated with conscious aftereffects induced by unseen stimuli in a blindsight subject
PNAS 2003 100: 10500-10505; published online before print August 19 2003, 10.1073/pnas.1734039100 [Abstract] [Full Text] [PDF]  

Jon Nilsen and Roberta Diaz Brinton
Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling
PNAS 2003 100: 10506-10511; published online before print August 18 2003, 10.1073/pnas.1334098100 [Abstract] [Full Text] [PDF]  

J. Michael Bradshaw, Yoshi Kubota, Tobias Meyer, and Howard Schulman
An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling
PNAS 2003 100: 10512-10517; published online before print August 19 2003, 10.1073/pnas.1932759100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Rusiko Bourtchouladze, Regina Lidge, Ray Catapano, Jennifer Stanley, Scott Gossweiler, Darlene Romashko, Rod Scott, and Tim Tully
A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4
PNAS 2003 100: 10518-10522; published online before print August 20 2003, 10.1073/pnas.1834280100 [Abstract] [Full Text] [PDF]  

Bryan Kolb, Grazyna Gorny, Yilin Li, Anne-Noël Samaha, and Terry E. Robinson
Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens
PNAS 2003 100: 10523-10528; published online before print August 25 2003, 10.1073/pnas.1834271100 [Abstract] [Full Text] [PDF]  

Pharmacology

Mohab M. Ibrahim, Hongfeng Deng, Alexander Zvonok, Debra A. Cockayne, Joyce Kwan, Heriberto P. Mata, Todd W. Vanderah, Josephine Lai, Frank Porreca, Alexandros Makriyannis, and T. Philip Malan, Jr.
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
PNAS 2003 100: 10529-10533; published online before print August 13 2003, 10.1073/pnas.1834309100 [Abstract] [Full Text] [PDF]  

Physiology

David R. Piper, Anthony Varghese, Michael C. Sanguinetti, and Martin Tristani-Firouzi
Gating currents associated with intramembrane charge displacement in HERG potassium channels
PNAS 2003 100: 10534-10539; published online before print August 19 2003, 10.1073/pnas.1832721100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Makoto Ishii, Hong Fei, and Jeffrey M. Friedman
Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity
PNAS 2003 100: 10540-10545; published online before print August 18 2003, 10.1073/pnas.1334189100 [Abstract] [Full Text] [PDF]  

Wei Yan, Lang Ma, Kathleen H. Burns, and Martin M. Matzuk
HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis
PNAS 2003 100: 10546-10551; published online before print August 14 2003, 10.1073/pnas.1837812100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Plant Biology

Eric A. Schmelz, Juergen Engelberth, Hans T. Alborn, Phillip O'Donnell, Matt Sammons, Hiroaki Toshima, and James H. Tumlinson, III
Simultaneous analysis of phytohormones, phytotoxins, and volatile organic compounds in plants
PNAS 2003 100: 10552-10557; published online before print July 21 2003, 10.1073/pnas.1633615100 [Abstract] [Full Text] [PDF]  
See Commentary on page 10144

Maxim Golovkin and Anireddy S. N. Reddy
A calmodulin-binding protein from Arabidopsis has an essential role in pollen germination
PNAS 2003 100: 10558-10563; published online before print August 19 2003, 10.1073/pnas.1734110100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Population Biology

Chris T. Bauch, Alison P. Galvani, and David J. D. Earn
Group interest versus self-interest in smallpox vaccination policy
PNAS 2003 100: 10564-10567; published online before print August 14 2003, 10.1073/pnas.1731324100 [Abstract] [Full Text] [PDF] [Supporting Information]  

CORRECTIONS

Correction for Bredenbeck et al., Picosecond conformational transition and equilibration of a cyclic peptide, PNAS 2003 100:6452-6457 [Extract] [Full Text] [PDF]  

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