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September 16, 2003; 100 (19)
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Cover image: Neutrophil phagocytosis of Streptococcus pyogenes. White blood cells engulf many types of pathogenic bacteria, which induce an apoptotic cascade that may aid in resolution of the infection. Paradoxically, S. pyogenes also causes white blood cell necrosis, which may contribute to pathogen survival and disease. See the article by Kobayashi et al. on pages 10948–10953.