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COMMENTARIES

Charles S. Spencer

War and early state formation in Oaxaca, Mexico
PNAS 2003 100: 11185-11187; published online before print September 23 2003, 10.1073/pnas.2034992100 [Extract] [Full Text] [PDF]  
See companion article on page 11801

David Sankoff and Joseph H. Nadeau

Chromosome rearrangements in evolution: From gene order to genome sequence and back
PNAS 2003 100: 11188-11189; published online before print September 23 2003, 10.1073/pnas.2035002100 [Extract] [Full Text] [PDF]  
See companion article on page 11484

Elena L. Grigorenko

The first candidate gene for dyslexia: Turning the page of a new chapter of research
PNAS 2003 100: 11190-11192; published online before print September 23 2003, 10.1073/pnas.2134926100 [Extract] [Full Text] [PDF]  
See companion article on page 11553

Ashley I. Bush, Colin L. Masters, and Rudolph E. Tanzi

Copper, -amyloid, and Alzheimer's disease: Tapping a sensitive connection
PNAS 2003 100: 11193-11194; published online before print September 23 2003, 10.1073/pnas.2135061100 [Extract] [Full Text] [PDF]  

D. Thirumalai, Dmitri K. Klimov, and George H. Lorimer

Caging helps proteins fold
PNAS 2003 100: 11195-11197; published online before print September 23 2003, 10.1073/pnas.2035072100 [Extract] [Full Text] [PDF]  
See companion article on page 11367

Michael P. Czech

Insulin's expanding control of forkheads
PNAS 2003 100: 11198-11200; published online before print September 23 2003, 10.1073/pnas.2135308100 [Extract] [Full Text] [PDF]  
See companion article on page 11624

PERSPECTIVES

Terence M. Doherty, Kamlesh Asotra, Lorraine A. Fitzpatrick, Jian-Hua Qiao, Douglas J. Wilkin, Robert C. Detrano, Colin R. Dunstan, Prediman K. Shah, and Tripathi B. Rajavashisth

Calcification in atherosclerosis: Bone biology and chronic inflammation at the arterial crossroads
PNAS 2003 100: 11201-11206; published online before print September 19 2003, 10.1073/pnas.1932554100 [Abstract] [Full Text] [PDF]  

David Eisenberg

The discovery of the -helix and -sheet, the principal structural features of proteins
PNAS 2003 100: 11207-11210; published online before print September 9 2003, 10.1073/pnas.2034522100 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

David Aldous and Allon G. Percus

Scaling and universality in continuous length combinatorial optimization
PNAS 2003 100: 11211-11215; published online before print September 22 2003, 10.1073/pnas.1635191100 [Abstract] [Full Text] [PDF]  

Joel Smoller and Blake Temple

Shock-wave cosmology inside a black hole
PNAS 2003 100: 11216-11218; published online before print September 12 2003, 10.1073/pnas.1833875100 [Abstract] [Full Text] [PDF]  

Astronomy

Joel Smoller and Blake Temple

Shock-wave cosmology inside a black hole
PNAS 2003 100: 11216-11218; published online before print September 12 2003, 10.1073/pnas.1833875100 [Abstract] [Full Text] [PDF]  

Chemistry

Andrey S. Klymchenko, Guy Duportail, Yves Mély, and Alexander P. Demchenko

Ultrasensitive two-color fluorescence probes for dipole potential in phospholipid membranes
PNAS 2003 100: 11219-11224; published online before print September 12 2003, 10.1073/pnas.1934603100 [Abstract] [Full Text] [PDF]  

Yi Qin Gao, Wei Yang, Rudolph A. Marcus, and Martin Karplus

A model for the cooperative free energy transduction and kinetics of ATP hydrolysis by F₁-ATPase
PNAS 2003 100: 11339-11344; published online before print September 18 2003, 10.1073/pnas.1334188100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geophysics

Piers M. de F. Forster and Susan Solomon

Observations of a "weekend effect" in diurnal temperature range
PNAS 2003 100: 11225-11230; published online before print September 18 2003, 10.1073/pnas.2034034100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Erik Trinkaus, Oana Moldovan, stefan Milota, Adrian Bîlgar, Laurentiu Sarcina, Sheela Athreya, Shara E. Bailey, Ricardo Rodrigo, Gherase Mircea, Thomas Higham, Christopher Bronk Ramsey, and Johannes van der Plicht

An early modern human from the Petera cu Oase, Romania
PNAS 2003 100: 11231-11236; published online before print September 22 2003, 10.1073/pnas.2035108100 [Abstract] [Full Text] [PDF]  

Kent V. Flannery and Joyce Marcus

The origin of war: New ¹⁴C dates from ancient Mexico
PNAS 2003 100: 11801-11805; published online before print September 18 2003, 10.1073/pnas.1934526100 [Abstract] [Full Text] [PDF]  
See Commentary on page 11185

Psychology

István Winkler, Elena Kushnerenko, János Horváth, Rita Ceponiene, Vineta Fellman, Minna Huotilainen, Risto Näätänen, and Elyse Sussman

Newborn infants can organize the auditory world
PNAS 2003 100: 11812-11815; published online before print September 19 2003, 10.1073/pnas.2031891100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Rui Mei, Earl Hubbell, Stefan Bekiranov, Mike Mittmann, Fred C. Christians, Mei-Mei Shen, Gang Lu, Joy Fang, Wei-Min Liu, Tom Ryder, Paul Kaplan, David Kulp, and Teresa A. Webster

Probe selection for high-density oligonucleotide arrays
PNAS 2003 100: 11237-11242; published online before print September 19 2003, 10.1073/pnas.1534744100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biochemistry

Matthew J. Harley and Joel F. Schildbach

Swapping single-stranded DNA sequence specificities of relaxases from conjugative plasmids F and R100
PNAS 2003 100: 11243-11248; published online before print September 22 2003, 10.1073/pnas.2035001100 [Abstract] [Full Text] [PDF]  

Lihong Wang, Cresson D. Fraley, Jesika Faridi, Arthur Kornberg, and Richard A. Roth

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells
PNAS 2003 100: 11249-11254; published online before print September 11 2003, 10.1073/pnas.1534805100 [Abstract] [Full Text] [PDF]  

M. A. Dwyer, L. L. Looger, and H. W. Hellinga

Computational design of a Zn²⁺ receptor that controls bacterial gene expression
PNAS 2003 100: 11255-11260; published online before print September 19 2003, 10.1073/pnas.2032284100 [Abstract] [Full Text] [PDF]  

Gui-in Lee, Zhaofeng Ding, John C. Walker, and Steven R. Van Doren

NMR structure of the forkhead-associated domain from the Arabidopsis receptor kinase-associated protein phosphatase
PNAS 2003 100: 11261-11266; published online before print September 18 2003, 10.1073/pnas.2031918100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Perry L. Howard, Marie C. Chia, Suzanne Del Rizzo, Fei-Fei Liu, and Tony Pawson

Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins
PNAS 2003 100: 11267-11272; published online before print September 17 2003, 10.1073/pnas.1934711100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Anne-Marie Leduc, John O. Trent, James L. Wittliff, Kelli S. Bramlett, Stephen L. Briggs, Nikolay Y. Chirgadze, Yong Wang, Thomas P. Burris, and Arno F. Spatola

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions
PNAS 2003 100: 11273-11278; published online before print September 17 2003, 10.1073/pnas.1934759100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jason W. Rausch, Jin Qu, Hye Young Yi-Brunozzi, Eric T. Kool, and Stuart F. J. Le Grice

Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection
PNAS 2003 100: 11279-11284; published online before print September 12 2003, 10.1073/pnas.1932546100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Hitomi Matsuzaki, Hiroaki Daitoku, Mitsutoki Hatta, Keiji Tanaka, and Akiyoshi Fukamizu

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
PNAS 2003 100: 11285-11290; published online before print September 17 2003, 10.1073/pnas.1934283100 [Abstract] [Full Text] [PDF]  

Flavio Da Fonseca and Bernard Moss

Poxvirus DNA topoisomerase knockout mutant exhibits decreased infectivity associated with reduced early transcription
PNAS 2003 100: 11291-11296; published online before print September 12 2003, 10.1073/pnas.1534874100 [Abstract] [Full Text] [PDF]  

Stéphane Skouloubris, Lluís Ribas de Pouplana, Hilde de Reuse, and Tamara L. Hendrickson

A noncognate aminoacyl-tRNA synthetase that may resolve a missing link in protein evolution
PNAS 2003 100: 11297-11302; published online before print September 17 2003, 10.1073/pnas.1932482100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Xiuli Xu, Man Cho, Netanya Y. Spencer, Neil Patel, Zhi Huang, Howard Shields, S. Bruce King, Mark T. Gladwin, Neil Hogg, and Daniel B. Kim-Shapiro

Measurements of nitric oxide on the heme iron and -93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation
PNAS 2003 100: 11303-11308; published online before print September 19 2003, 10.1073/pnas.2033883100 [Abstract] [Full Text] [PDF]  

Yoav Paas, Jean Cartaud, Michel Recouvreur, Regis Grailhe, Virginie Dufresne, Eva Pebay-Peyroula, Ehud M. Landau, and Jean-Pierre Changeux

Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid–detergent matrices
PNAS 2003 100: 11309-11314; published online before print September 17 2003, 10.1073/pnas.1834451100 [Abstract] [Full Text] [PDF]  

Kara S. Giddings, Arthur E. Johnson, and Rodney K. Tweten

Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins
PNAS 2003 100: 11315-11320; published online before print September 19 2003, 10.1073/pnas.2033520100 [Abstract] [Full Text] [PDF]  

Gwendolyn Barceló-Coblijn, Endre Hogyes, Klára Kitajka, László G. Puskás, Ágnes Zvara, László Hackler, Jr., Csaba Nyakas, Zsuzsa Penke, and Tibor Farkas

Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids
PNAS 2003 100: 11321-11326; published online before print September 17 2003, 10.1073/pnas.1734008100 [Abstract] [Full Text] [PDF]  

Heather L. Wiegand, Shihua Lu, and Bryan R. Cullen

Exon junction complexes mediate the enhancing effect of splicing on mRNA expression
PNAS 2003 100: 11327-11332; published online before print September 12 2003, 10.1073/pnas.1934877100 [Abstract] [Full Text] [PDF]  

Biophysics

Andrey S. Klymchenko, Guy Duportail, Yves Mély, and Alexander P. Demchenko

Ultrasensitive two-color fluorescence probes for dipole potential in phospholipid membranes
PNAS 2003 100: 11219-11224; published online before print September 12 2003, 10.1073/pnas.1934603100 [Abstract] [Full Text] [PDF]  

Jérôme Boisbouvier, Frank Delaglio, and Ad Bax Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Direct observation of dipolar couplings between distant protons in weakly aligned nucleic acids PNAS 2003 100: 11333-11338; published online before print September 12 2003, 10.1073/pnas.1534664100 [Abstract] [Full Text] [PDF]

Yi Qin Gao, Wei Yang, Rudolph A. Marcus, and Martin Karplus

A model for the cooperative free energy transduction and kinetics of ATP hydrolysis by F₁-ATPase
PNAS 2003 100: 11339-11344; published online before print September 18 2003, 10.1073/pnas.1334188100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Srebrenka Robic, Mercedes Guzman-Casado, Jose M. Sanchez-Ruiz, and Susan Marqusee

Role of residual structure in the unfolded state of a thermophilic protein
PNAS 2003 100: 11345-11349; published online before print September 22 2003, 10.1073/pnas.1635051100 [Abstract] [Full Text] [PDF]  

L. Cognet, C. Tardin, D. Boyer, D. Choquet, P. Tamarat, and B. Lounis

Single metallic nanoparticle imaging for protein detection in cells
PNAS 2003 100: 11350-11355; published online before print September 17 2003, 10.1073/pnas.1534635100 [Abstract] [Full Text] [PDF] [Supporting Movie]  

K. Blank, T. Mai, I. Gilbert, S. Schiffmann, J. Rankl, R. Zivin, C. Tackney, T. Nicolaus, K. Spinnler, F. Oesterhelt, M. Benoit, H. Clausen-Schaumann, and H. E. Gaub

A force-based protein biochip
PNAS 2003 100: 11356-11360; published online before print September 15 2003, 10.1073/pnas.1934928100 [Abstract] [Full Text] [PDF]  

Jimin Pei, Nikolay V. Dokholyan, Eugene I. Shakhnovich, and Nick V. Grishin

Using protein design for homology detection and active site searches
PNAS 2003 100: 11361-11366; published online before print September 15 2003, 10.1073/pnas.2034878100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Fumiko Takagi, Nobuyasu Koga, and Shoji Takada From the Cover: How protein thermodynamics and folding mechanisms are altered by the chaperonin cage: Molecular simulations PNAS 2003 100: 11367-11372; published online before print August 28 2003, 10.1073/pnas.1831920100 [Abstract] [Full Text] [PDF] [Supporting Information]   See Commentary on page 11195

Giuseppe Lia, David Bensimon, Vincent Croquette, Jean-Francois Allemand, David Dunlap, Dale E. A. Lewis, Sankar Adhya, and Laura Finzi

Supercoiling and denaturation in Gal repressor/heat unstable nucleoid protein (HU)-mediated DNA looping
PNAS 2003 100: 11373-11377; published online before print September 18 2003, 10.1073/pnas.2034851100 [Abstract] [Full Text] [PDF] [Supporting Text]  

O. K. Dudko, A. E. Filippov, J. Klafter, and M. Urbakh

Beyond the conventional description of dynamic force spectroscopy of adhesion bonds
PNAS 2003 100: 11378-11381; published online before print September 17 2003, 10.1073/pnas.1534554100 [Abstract] [Full Text] [PDF]  

Gail E. Fanucci, Nathalie Cadieux, Robert J. Kadner, and David S. Cafiso

Competing ligands stabilize alternate conformations of the energy coupling motif of a TonB-dependent outer membrane transporter
PNAS 2003 100: 11382-11387; published online before print September 17 2003, 10.1073/pnas.1932486100 [Abstract] [Full Text] [PDF]  

Jorge E. Contreras, Juan C. Sáez, Feliksas F. Bukauskas, and Michael V. L. Bennett

Gating and regulation of connexin 43 (Cx43) hemichannels
PNAS 2003 100: 11388-11393; published online before print September 16 2003, 10.1073/pnas.1434298100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cell Biology

Brian P. Kelley, Roded Sharan, Richard M. Karp, Taylor Sittler, David E. Root, Brent R. Stockwell, and Trey Ideker

Conserved pathways within bacteria and yeast as revealed by global protein network alignment
PNAS 2003 100: 11394-11399; published online before print September 22 2003, 10.1073/pnas.1534710100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tracey M. Rowlands, Irina V. Pechenkina, Sarah J. Hatsell, Richard G. Pestell, and Pamela Cowin

Dissecting the roles of -catenin and cyclin D1 during mammary development and neoplasia
PNAS 2003 100: 11400-11405; published online before print September 17 2003, 10.1073/pnas.1534601100 [Abstract] [Full Text] [PDF]  

Mounia Azzi, Pascale G. Charest, Stéphane Angers, Guy Rousseau, Trudy Kohout, Michel Bouvier, and Graciela Piñeyro

-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
PNAS 2003 100: 11406-11411; published online before print September 17 2003, 10.1073/pnas.1936664100 [Abstract] [Full Text] [PDF]  

T. E. Schneider, C. Barland, A. M. Alex, M. L. Mancianti, Y. Lu, J. E. Cleaver, H. J. Lawrence, and R. Ghadially

Measuring stem cell frequency in epidermis: A quantitative in vivo functional assay for long-term repopulating cells
PNAS 2003 100: 11412-11417; published online before print September 17 2003, 10.1073/pnas.2034935100 [Abstract] [Full Text] [PDF]  

Olga Pontes, Richard J. Lawrence, Nuno Neves, Manuela Silva, Jae-Hyeok Lee, Z. Jeffrey Chen, Wanda Viegas, and Craig S. Pikaard

Natural variation in nucleolar dominance reveals the relationship between nucleolus organizer chromatin topology and rRNA gene transcription in Arabidopsis
PNAS 2003 100: 11418-11423; published online before print September 22 2003, 10.1073/pnas.1932522100 [Abstract] [Full Text] [PDF]  

Michael P. Yaffe, Nico Stuurman, and Ronald D. Vale

Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles
PNAS 2003 100: 11424-11428; published online before print September 12 2003, 10.1073/pnas.1534703100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

K. A. Shepard, A. P. Gerber, A. Jambhekar, P. A. Takizawa, P. O. Brown, D. Herschlag, J. L. DeRisi, and R. D. Vale

Widespread cytoplasmic mRNA transport in yeast: Identification of 22 bud-localized transcripts using DNA microarray analysis
PNAS 2003 100: 11429-11434; published online before print September 17 2003, 10.1073/pnas.2033246100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ming Yi, Takao Sakai, Reinhard Fässler, and Erkki Ruoslahti

Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity
PNAS 2003 100: 11435-11438; published online before print September 17 2003, 10.1073/pnas.1635112100 [Abstract] [Full Text] [PDF]  

Edward P. Browne and Thomas Shenk

Human cytomegalovirus UL83-coded pp65 virion protein inhibits antiviral gene expression in infected cells
PNAS 2003 100: 11439-11444; published online before print September 12 2003, 10.1073/pnas.1534570100 [Abstract] [Full Text] [PDF]  

Alicia Algeciras-Schimnich, Eric M. Pietras, Bryan C. Barnhart, Patrick Legembre, Shrijay Vijayan, Susan L. Holbeck, and Marcus E. Peter

Two CD95 tumor classes with different sensitivities to antitumor drugs
PNAS 2003 100: 11445-11450; published online before print September 22 2003, 10.1073/pnas.2034995100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Developmental Biology

Nancy Fossett, Kristy Hyman, Kathleen Gajewski, Stuart H. Orkin, and Robert A. Schulz

Combinatorial interactions of Serpent, Lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis
PNAS 2003 100: 11451-11456; published online before print September 22 2003, 10.1073/pnas.1635050100 [Abstract] [Full Text] [PDF]  

Yayoi Toyooka, Naoki Tsunekawa, Ryuko Akasu, and Toshiaki Noce

Embryonic stem cells can form germ cells in vitro
PNAS 2003 100: 11457-11462; published online before print September 22 2003, 10.1073/pnas.1932826100 [Abstract] [Full Text] [PDF]  

Elisa C. Woodhouse, Amy Fisher, Russell W. Bandle, Bianca Bryant-Greenwood, Lula Charboneau, Emanuel F. Petricoin, III, and Lance A. Liotta

Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype
PNAS 2003 100: 11463-11468; published online before print September 19 2003, 10.1073/pnas.2031202100 [Abstract] [Full Text] [PDF]  

Brad Davidson and Michael Levine

Evolutionary origins of the vertebrate heart: Specification of the cardiac lineage in Ciona intestinalis
PNAS 2003 100: 11469-11473; published online before print September 18 2003, 10.1073/pnas.1634991100 [Abstract] [Full Text] [PDF]  

Ecology

Catherine E. Burns, Kevin M. Johnston, and Oswald J. Schmitz

Global climate change and mammalian species diversity in U.S. national parks
PNAS 2003 100: 11474-11477; published online before print September 19 2003, 10.1073/pnas.1635115100 [Abstract] [Full Text] [PDF]  

Nils C. Stenseth, Hildegunn Viljugrein, Takashi Saitoh, Thomas F. Hansen, Marte O. Kittilsen, Erik Bølviken, and Fredrik Glöckner

Seasonality, density dependence, and population cycles in Hokkaido voles
PNAS 2003 100: 11478-11483; published online before print September 22 2003, 10.1073/pnas.1935306100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Evolution

W. James Kent, Robert Baertsch, Angie Hinrichs, Webb Miller, and David Haussler

Evolution's cauldron: Duplication, deletion, and rearrangement in the mouse and human genomes
PNAS 2003 100: 11484-11489; published online before print September 19 2003, 10.1073/pnas.1932072100 [Abstract] [Full Text] [PDF] [Supporting Table]  
See Commentary on page 11188

Charles Linn, Jr., Jeffrey L. Feder, Satoshi Nojima, Hattie R. Dambroski, Stewart H. Berlocher, and Wendell Roelofs

Fruit odor discrimination and sympatric host race formation in Rhagoletis
PNAS 2003 100: 11490-11493; published online before print September 22 2003, 10.1073/pnas.1635049100 [Abstract] [Full Text] [PDF]  

Jan Pawlowski, Maria Holzmann, Cédric Berney, José Fahrni, Andrew J. Gooday, Tomas Cedhagen, Andrea Habura, and Samuel S. Bowser

The evolution of early Foraminifera
PNAS 2003 100: 11494-11498; published online before print September 22 2003, 10.1073/pnas.2035132100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Ying Chen and Wolfgang Stephan

Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene
PNAS 2003 100: 11499-11504; published online before print September 12 2003, 10.1073/pnas.1932834100 [Abstract] [Full Text] [PDF]  

Genetics

Chikara Hoshikawa, Mika Shichiri, Shigeru Nakamori, and Hiroshi Takagi

A nonconserved Ala401 in the yeast Rsp5 ubiquitin ligase is involved in degradation of Gap1 permease and stress-induced abnormal proteins
PNAS 2003 100: 11505-11510; published online before print September 18 2003, 10.1073/pnas.1933153100 [Abstract] [Full Text] [PDF]  

Carl T. Bergstrom, Erin McKittrick, and Rustom Antia

Mathematical models of RNA silencing: Unidirectional amplification limits accidental self-directed reactions
PNAS 2003 100: 11511-11516; published online before print September 12 2003, 10.1073/pnas.1931639100 [Abstract] [Full Text] [PDF]  

Eric S. Martin, Rossano Cesari, Francesca Pentimalli, Kristine Yoder, Richard Fishel, Andrew L. Himelstein, S. Eric Martin, Andrew K. Godwin, Massimo Negrini, and Carlo M. Croce

The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene
PNAS 2003 100: 11517-11522; published online before print September 22 2003, 10.1073/pnas.1934602100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Iraida G. Sharina, Emil Martin, Anthony Thomas, Karen L. Uray, and Ferid Murad

CCAAT-binding factor regulates expression of the ₁ subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line
PNAS 2003 100: 11523-11528; published online before print September 22 2003, 10.1073/pnas.1934338100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Meng-Er Huang, Anne-Gaëlle Rio, Alain Nicolas, and Richard D. Kolodner

A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations
PNAS 2003 100: 11529-11534; published online before print September 12 2003, 10.1073/pnas.2035018100 [Abstract] [Full Text] [PDF]  

Kristin Nastase Byrd and Allen Shearn

ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3
PNAS 2003 100: 11535-11540; published online before print September 17 2003, 10.1073/pnas.1933593100 [Abstract] [Full Text] [PDF]  

Bruce P. May, Hong Liu, Erik Vollbrecht, Lynn Senior, Pablo D. Rabinowicz, Donna Roh, Xiaokang Pan, Lincoln Stein, Mike Freeling, Danny Alexander, and Rob Martienssen

Maize-targeted mutagenesis: A knockout resource for maize
PNAS 2003 100: 11541-11546; published online before print September 3 2003, 10.1073/pnas.1831119100 [Abstract] [Full Text] [PDF]  

Michael Overholtzer, Pulivarthi H. Rao, Reyna Favis, Xin-Yan Lu, Michael B. Elowitz, Francis Barany, Marc Ladanyi, Richard Gorlick, and Arnold J. Levine

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
PNAS 2003 100: 11547-11552; published online before print September 12 2003, 10.1073/pnas.1934852100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Mikko Taipale, Nina Kaminen, Jaana Nopola-Hemmi, Tuomas Haltia, Birgitta Myllyluoma, Heikki Lyytinen, Kurt Muller, Minna Kaaranen, Perttu J. Lindsberg, Katariina Hannula-Jouppi, and Juha Kere From the Cover: A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain PNAS 2003 100: 11553-11558; published online before print September 3 2003, 10.1073/pnas.1833911100 [Abstract] [Full Text] [PDF]   See Commentary on page 11190

Xiao-bo Zhong, Robert Reynolds, Judith R. Kidd, Kenneth K. Kidd, Robert Jenison, Richard A. Marlar, and David C. Ward

Single-nucleotide polymorphism genotyping on optical thin-film biosensor chips
PNAS 2003 100: 11559-11564; published online before print September 15 2003, 10.1073/pnas.1934783100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Immunology

Eric S. Huseby, Frances Crawford, Janice White, John Kappler, and Philippa Marrack

Negative selection imparts peptide specificity to the mature T cell repertoire
PNAS 2003 100: 11565-11570; published online before print September 22 2003, 10.1073/pnas.1934636100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Thai M. Cao, Betty Lo, Erik A. Ranheim, F. Carl Grumet, and Judith A. Shizuru

Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice
PNAS 2003 100: 11571-11576; published online before print September 22 2003, 10.1073/pnas.2035077100 [Abstract] [Full Text] [PDF]  

Katrina B. Morshead, David N. Ciccone, Sean D. Taverna, C. David Allis, and Marjorie A. Oettinger

Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4
PNAS 2003 100: 11577-11582; published online before print September 19 2003, 10.1073/pnas.1932643100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Maaike E. Ressing, Daphne van Leeuwen, Frank A. W. Verreck, Raquel Gomez, Bianca Heemskerk, Mireille Toebes, Maureen M. Mullen, Theodore S. Jardetzky, Richard Longnecker, Marco W. Schilham, Tom H. M. Ottenhoff, Jacques Neefjes, Ton N. Schumacher, Lindsey M. Hutt-Fletcher, and Emmanuel J. H. J. Wiertz

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition
PNAS 2003 100: 11583-11588; published online before print September 22 2003, 10.1073/pnas.2034960100 [Abstract] [Full Text] [PDF]  

Elizabeth A. Mellor, Nita Frank, Dulce Soler, Martin R. Hodge, Jose M. Lora, K. Frank Austen, and Joshua A. Boyce

Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R
PNAS 2003 100: 11589-11593; published online before print September 17 2003, 10.1073/pnas.2034927100 [Abstract] [Full Text] [PDF]  

Michael H. Shaw, Victor Boyartchuk, Sandy Wong, Marina Karaghiosoff, Josiane Ragimbeau, Sandra Pellegrini, Mathias Muller, William F. Dietrich, and George S. Yap

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity
PNAS 2003 100: 11594-11599; published online before print September 18 2003, 10.1073/pnas.1930781100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Medical Sciences

Celina G. Kleer, Qi Cao, Sooryanarayana Varambally, Ronglai Shen, Ichiro Ota, Scott A. Tomlins, Debashis Ghosh, Richard G. A. B. Sewalt, Arie P. Otte, Daniel F. Hayes, Michael S. Sabel, Donna Livant, Stephen J. Weiss, Mark A. Rubin, and Arul M. Chinnaiyan

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
PNAS 2003 100: 11606-11611; published online before print September 19 2003, 10.1073/pnas.1933744100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chanil Moon, Melissa Krawczyk, Dongchoon Ahn, Ismayil Ahmet, Doojin Paik, Edward G. Lakatta, and Mark I. Talan

Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats
PNAS 2003 100: 11612-11617; published online before print September 19 2003, 10.1073/pnas.1930406100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Matt X. G. Shao, Iris F. Ueki, and Jay A. Nadel

Tumor necrosis factor -converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells
PNAS 2003 100: 11618-11623; published online before print September 12 2003, 10.1073/pnas.1534804100 [Abstract] [Full Text] [PDF]  

Christian Wolfrum, Daniel Besser, Edlira Luca, and Markus Stoffel From the Cover: Insulin regulates the activity of forkhead transcription factor Hnf-3/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization PNAS 2003 100: 11624-11629; published online before print September 19 2003, 10.1073/pnas.1931483100 [Abstract] [Full Text] [PDF] [Supporting Figure]   See Commentary on page 11198

Stephane Wong, Jami McLaughlin, Donghui Cheng, Kevin Shannon, Lorraine Robb, and Owen N. Witte

IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease
PNAS 2003 100: 11630-11635; published online before print September 19 2003, 10.1073/pnas.2035020100 [Abstract] [Full Text] [PDF]  

Zhuo Zhang, Mao Li, Hui Wang, Sudhir Agrawal, and Ruiwen Zhang

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy
PNAS 2003 100: 11636-11641; published online before print September 16 2003, 10.1073/pnas.1934692100 [Abstract] [Full Text] [PDF] [Supporting Information]  

J. H. Oliver, Jr., T. Lin, L. Gao, K. L. Clark, C. W. Banks, L. A. Durden, A. M. James, and F. W. Chandler, Jr.

An enzootic transmission cycle of Lyme borreliosis spirochetes in the southeastern United States
PNAS 2003 100: 11642-11645; published online before print September 19 2003, 10.1073/pnas.1434553100 [Abstract] [Full Text] [PDF] [Supporting Appendixies]  

Akito Sakai, Marisa St. Claire, Kristina Faulk, Sugantha Govindarajan, Suzanne U. Emerson, Robert H. Purcell, and Jens Bukh

The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences
PNAS 2003 100: 11646-11651; published online before print September 22 2003, 10.1073/pnas.1834545100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Brazilian National Genome Project Consortium:, Ana Tereza Ribeiro de Vasconcelos, Darcy F. de Almeida, Mariangela Hungria, Claudia Teixeira Guimarães, Regina Vasconcellos Antônio, Francisca Cunha Almeida, Luiz G. P. de Almeida, Rosana de Almeida, José Antonio Alves-Gomes, Elizabeth Mazoni Andrade, Julia Araripe, Magnólia Fernandes Florêncio de Araújo, Spartaco Astolfi-Filho, Vasco Azevedo, Alessandra Jorge Baptista, Luiz Artur Mendes Bataus, Jacqueline da Silva Batista, André Beló, Cássio van den Berg, Maurício Bogo, Sandro Bonatto, Juliano Bordignon, Marcelo Macedo Brigido, Cristiana Alves Brito, Marcelo Brocchi, Helio Almeida Burity, Anamaria Aranha Camargo, Divina das Dores de Paula Cardoso, Newton Portilho Carneiro, Dirce Maria Carraro, Cláudia Márcia Benedetto Carvalho, Júlio Cézar de Mattos Cascardo, Benildo Sousa Cavada, Ligia Maria O. Chueire, Tânia Beatriz Creczynski-Pasa, Nivaldo Costa da Cunha-Junior, Nelson Fagundes, Clarissa Lima Falcão, Fabiana Fantinatti, Izeni Pires Farias, Maria Sueli Soares Felipe, Lilian Pereira Ferrari, Jesus Aparecido Ferro, Maria Inês Tiraboschi Ferro, Gloria Regina Franco, Nara Suzy Aguiar de Freitas, Luiz Roberto Furlan, Ricardo Tostes Gazzinelli, Eliane Aparecida Gomes, Pablo Rodrigues Gonçalves, Thalles Barbosa Grangeiro, Dario Grattapaglia, Edmundo Carlos Grisard, Ebert Seixas Hanna, Sílvia Neto Jardim, Jomar Laurino, Lélia Cristina Tenório Leoi, Lucymara Fassarella Agnez Lima, Maria de Fatima Loureiro, Maria do Carmo Catanho Pereira de Lyra, Humberto Maciel França Madeira, Gilson Paulo Manfio, Andrea Queiroz Maranhão, Wellington Santos Martins, Sônia Marli Zingaretti di Mauro, Silvia Regina Batistuzzo de Medeiros, Rosely de Vasconcellos Meissner, Miguel Angelo Martins Moreira, Fabrícia Ferreira do Nascimento, Marisa Fabiana Nicolás, Jaquelline Germano Oliveira, Sergio Costa Oliveira, Roger Ferreira Cury Paixão, Juliana Alves Parente, Fabio de Oliveira Pedrosa, Sergio Danilo Junho Pena, José Odair Pereira, Maristela Pereira, Luciana Santos Rodrigues Costa Pinto, Luciano da Silva Pinto, Jorge Ivan Rebelo Porto, Deise Porto Potrich, Cicero Eduardo Ramalho-Neto, Alessandra Maria Moreira Reis, Liu Um Rigo, Edson Rondinelli, Elen Bethleen Pedraça do Santos, Fabrício R. Santos, Maria Paula Cruz Schneider, Hector N. Seuanez, Ana Maria Rodrigues Silva, Artur Luiz da Costa da Silva, Denise Wanderlei Silva, Rosane Silva, Isabella de Carmo Simões, Daniel Simon, Célia Maria de Almeida Soares, Renata de Bastos Ascenço Soares, Emanuel Maltempi Souza, Kelly Rose Lobo de Souza, Rangel Celso Souza, Maria Berenice Reynaud Steffens, Mário Steindel, Santuza Ribeiro Teixeira, Turan Urmenyi, André Vettore, Roseli Wassem, Arnaldo Zaha, and Andrew John George Simpson

The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability
PNAS 2003 100: 11660-11665; published online before print September 18 2003, 10.1073/pnas.1832124100 [Abstract] [Full Text] [PDF]  

P.-C. Klöhn, L. Stoltze, E. Flechsig, M. Enari, and C. Weissmann

A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions
PNAS 2003 100: 11666-11671; published online before print September 22 2003, 10.1073/pnas.1834432100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Theresa L.-Y. Chang, Chia-Hwa Chang, David A. Simpson, Qiang Xu, Patrick K. Martin, Laurel A. Lagenaur, Gary K. Schoolnik, David D. Ho, Sharon L. Hillier, Mark Holodniy, John A. Lewicki, and Peter P. Lee

Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4
PNAS 2003 100: 11672-11677; published online before print September 12 2003, 10.1073/pnas.1934747100 [Abstract] [Full Text] [PDF]  

Marcy R. Auerbach, Chang Shu, Artem Kaplan, and Ila R. Singh

Functional characterization of a portion of the Moloney murine leukemia virus gag gene by genetic footprinting
PNAS 2003 100: 11678-11683; published online before print September 22 2003, 10.1073/pnas.2034020100 [Abstract] [Full Text] [PDF]  

Julie A. Boylan, James E. Posey, and Frank C. Gherardini

Borrelia oxidative stress response regulator, BosR: A distinctive Zn-dependent transcriptional activator
PNAS 2003 100: 11684-11689; published online before print September 15 2003, 10.1073/pnas.2032956100 [Abstract] [Full Text] [PDF]  

Claudia Baar, Mark Eppinger, Guenter Raddatz, Jörg Simon, Christa Lanz, Oliver Klimmek, Ramkumar Nandakumar, Roland Gross, Andrea Rosinus, Heike Keller, Pratik Jagtap, Burkhard Linke, Folker Meyer, Hermann Lederer, and Stephan C. Schuster

Complete genome sequence and analysis of Wolinella succinogenes
PNAS 2003 100: 11690-11695; published online before print September 19 2003, 10.1073/pnas.1932838100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Mary F. Dallman, Norman Pecoraro, Susan F. Akana, Susanne E. la Fleur, Francisca Gomez, Hani Houshyar, M. E. Bell, Seema Bhatnagar, Kevin D. Laugero, and Sotara Manalo

Chronic stress and obesity: A new view of "comfort food"
PNAS 2003 100: 11696-11701; published online before print September 15 2003, 10.1073/pnas.1934666100 [Abstract] [Full Te