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COMMENTARIES

David E. Wemmer

The energetics of structural change in maltose-binding protein
PNAS 2003 100: 12529-12530; published online before print October 20 2003, 10.1073/pnas.2335923100 [Extract] [Full Text] [PDF]  
See companion article on page 12700

Mark C. Hersam and Yip-Wah Chung

Detecting elusive surface atoms with atomic force microscopy
PNAS 2003 100: 12531-12532; published online before print October 20 2003, 10.1073/pnas.2335865100 [Extract] [Full Text] [PDF]  
See companion article on page 12539

Kyle Summers

Convergent evolution of bright coloration and toxicity in frogs
PNAS 2003 100: 12533-12534; published online before print October 20 2003, 10.1073/pnas.2335928100 [Extract] [Full Text] [PDF]  
See companion article on page 12792

Gordon M. Shepherd

The single capillary and the active brain
PNAS 2003 100: 12535-12536; published online before print October 20 2003, 10.1073/pnas.2336089100 [Extract] [Full Text] [PDF]  
See companion article on page 13081

Ronald F. Fox

Using nonequilibrium measurements to determine macromolecule free-energy differences
PNAS 2003 100: 12537-12538; published online before print October 20 2003, 10.1073/pnas.2336065100 [Extract] [Full Text] [PDF]  
See companion article on page 12564

PHYSICAL SCIENCES

Applied Physical Sciences

Chemistry

Elizabeth M. Boon, Alison L. Livingston, Nikolas H. Chmiel, Sheila S. David, and Jacqueline K. Barton

DNA-mediated charge transport for DNA repair
PNAS 2003 100: 12543-12547; published online before print October 14 2003, 10.1073/pnas.2035257100 [Abstract] [Full Text] [PDF]  

Michael C. Pirrung, Wolfgang H. Pieper, Krishna P. Kaliappan, and Mugunthu R. Dhananjeyan

Combinatorial discovery of two-photon photoremovable protecting groups
PNAS 2003 100: 12548-12553; published online before print October 13 2003, 10.1073/pnas.2131115100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geology

Fabien Kenig, Dirk-Jan H. Simons, David Crich, James P. Cowen, Gregory T. Ventura, Tatiana Rehbein-Khalily, Todd C. Brown, and Ken B. Anderson

Branched aliphatic alkanes with quaternary substituted carbon atoms in modern and ancient geologic samples
PNAS 2003 100: 12554-12558; published online before print October 9 2003, 10.1073/pnas.1735581100 [Abstract] [Full Text] [PDF]  

Larry Benson, Linda Cordell, Kirk Vincent, Howard Taylor, John Stein, G. Lang Farmer, and Kiyoto Futa

Ancient maize from Chacoan great houses: Where was it grown?
PNAS 2003 100: 13111-13115; published online before print October 16 2003, 10.1073/pnas.2135068100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mathematics

Victor Guillemin, Shlomo Sternberg, and Jonathan Weitsman

Signature quantization
PNAS 2003 100: 12559-12560; published online before print October 20 2003, 10.1073/pnas.1735527100 [Abstract] [Full Text] [PDF]  

Ivan P. Shestakov and Ualbai U. Umirbaev

The Nagata automorphism is wild
PNAS 2003 100: 12561-12563; published online before print October 20 2003, 10.1073/pnas.1735483100 [Abstract] [Full Text] [PDF]  

Physics

O. Miyashita, J. N. Onuchic, and P. G. Wolynes

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
PNAS 2003 100: 12570-12575; published online before print October 17 2003, 10.1073/pnas.2135471100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Jian Zi, Xindi Yu, Yizhou Li, Xinhua Hu, Chun Xu, Xingjun Wang, Xiaohan Liu, and Rongtang Fu

Coloration strategies in peacock feathers
PNAS 2003 100: 12576-12578; published online before print October 13 2003, 10.1073/pnas.2133313100 [Abstract] [Full Text] [PDF]  

Statistics

Manoj Pratim Samanta and Shoudan Liang

Predicting protein functions from redundancies in large-scale protein interaction networks
PNAS 2003 100: 12579-12583; published online before print October 17 2003, 10.1073/pnas.2132527100 [Abstract] [Full Text] [PDF] [Supporting Information]  

SOCIAL SCIENCES

Anthropology

Larry Benson, Linda Cordell, Kirk Vincent, Howard Taylor, John Stein, G. Lang Farmer, and Kiyoto Futa

Ancient maize from Chacoan great houses: Where was it grown?
PNAS 2003 100: 13111-13115; published online before print October 16 2003, 10.1073/pnas.2135068100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Psychology

Beatrice de Gelder, Ilja Frissen, Jason Barton, and Nouchine Hadjikhani

A modulatory role for facial expressions in prosopagnosia
PNAS 2003 100: 13105-13110; published online before print October 15 2003, 10.1073/pnas.1735530100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Niharika Nath, Khosrow Kashfi, Jie Chen, and Basil Rigas

Nitric oxide-donating aspirin inhibits -catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear -catenin–TCF association
PNAS 2003 100: 12584-12589; published online before print October 17 2003, 10.1073/pnas.2134840100 [Abstract] [Full Text] [PDF]  

Biochemistry

Elizabeth M. Boon, Alison L. Livingston, Nikolas H. Chmiel, Sheila S. David, and Jacqueline K. Barton

DNA-mediated charge transport for DNA repair
PNAS 2003 100: 12543-12547; published online before print October 14 2003, 10.1073/pnas.2035257100 [Abstract] [Full Text] [PDF]  

Norbert Schülke, Olga A. Varlamova, Gerald P. Donovan, Dangshe Ma, Jason P Gardner, Donna M. Morrissey, Robert R. Arrigale, Cenchen Zhan, Amy J. Chodera, Kenneth G. Surowitz, Paul J. Maddon, Warren D. W. Heston, and William C. Olson

The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy
PNAS 2003 100: 12590-12595. [Abstract] [Full Text] [PDF] [Supporting Text]  

P. C. Joost Haasnoot, John F. Bol, and René C. L. Olsthoorn

A plant virus replication system to assay the formation of RNA pseudotriloop motifs in RNA–protein interactions
PNAS 2003 100: 12596-12600; published online before print October 20 2003, 10.1073/pnas.2135413100 [Abstract] [Full Text] [PDF]  

Brandon E. Aubol, Sutapa Chakrabarti, Jacky Ngo, Jennifer Shaffer, Brad Nolen, Xiang-Dong Fu, Gourisankar Ghosh, and Joseph A. Adams

Processive phosphorylation of alternative splicing factor/splicing factor 2
PNAS 2003 100: 12601-12606; published online before print October 10 2003, 10.1073/pnas.1635129100 [Abstract] [Full Text] [PDF]  

Olga Sokolova, Alessio Accardi, David Gutierrez, Adrian Lau, Mike Rigney, and Nikolaus Grigorieff

Conformational changes in the C terminus of Shaker K⁺ channel bound to the rat Kv2-subunit
PNAS 2003 100: 12607-12612; published online before print October 20 2003, 10.1073/pnas.2235650100 [Abstract] [Full Text] [PDF]  

Julio Blanco, Roger A. Moore, and Ronald E. Viola

Capture of an intermediate in the catalytic cycle of L-aspartate--semialdehyde dehydrogenase
PNAS 2003 100: 12613-12617; published online before print October 14 2003, 10.1073/pnas.1634958100 [Abstract] [Full Text] [PDF]  

Stephan Gromer, Linda Johansson, Holger Bauer, L. David Arscott, Susanne Rauch, David P. Ballou, Charles H. Williams, Jr., R. Heiner Schirmer, and Elias S. J. Arnér

Active sites of thioredoxin reductases: Why selenoproteins?
PNAS 2003 100: 12618-12623; published online before print October 20 2003, 10.1073/pnas.2134510100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Zhiyuan Hu, Seung Hun Cha, Shigeru Chohnan, and M. Daniel Lane

Hypothalamic malonyl-CoA as a mediator of feeding behavior
PNAS 2003 100: 12624-12629; published online before print October 7 2003, 10.1073/pnas.1834402100 [Abstract] [Full Text] [PDF]  

Visvanathan Ramamurthy, Melanie Roberts, Focco van den Akker, Gregory Niemi, T. A. Reh, and James B. Hurley

AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteins
PNAS 2003 100: 12630-12635; published online before print October 10 2003, 10.1073/pnas.2134194100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Siiri E. Iismaa, Sara Holman, Merridee A. Wouters, Laszlo Lorand, Robert M. Graham, and Ahsan Husain

Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases
PNAS 2003 100: 12636-12641; published online before print October 17 2003, 10.1073/pnas.1635052100 [Abstract] [Full Text] [PDF]  

Zhongqiu Zhang, Manabu Futamura, Haris G. Vikis, Min Wang, Jie Li, Yian Wang, Kun-Liang Guan, and Ming You

Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice
PNAS 2003 100: 12642-12647. [Abstract] [Full Text] [PDF]  

Hu Pan, Sanjay Agarwalla, Demetri T. Moustakas, Janet Finer-Moore, and Robert M. Stroud

Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit
PNAS 2003 100: 12648-12653; published online before print October 17 2003, 10.1073/pnas.2135585100 [Abstract] [Full Text] [PDF]  

Nikolaus Schiering, Stefan Knapp, Marina Marconi, Maria M. Flocco, Jean Cui, Rita Perego, Luisa Rusconi, and Cinzia Cristiani

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
PNAS 2003 100: 12654-12659; published online before print October 14 2003, 10.1073/pnas.1734128100 [Abstract] [Full Text] [PDF]  

Jie Wang, Gene Webb, Yun Cao, and Donald F. Steiner

Contrasting patterns of expression of transcription factors in pancreatic and cells
PNAS 2003 100: 12660-12665; published online before print October 13 2003, 10.1073/pnas.1735286100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Meisheng Zhou, Longwen Deng, Fatah Kashanchi, John N. Brady, Aaron J. Shatkin, and Ajit Kumar

The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA
PNAS 2003 100: 12666-12671; published online before print October 20 2003, 10.1073/pnas.1835726100 [Abstract] [Full Text] [PDF]  

Biophysics

O. Miyashita, J. N. Onuchic, and P. G. Wolynes

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins
PNAS 2003 100: 12570-12575; published online before print October 17 2003, 10.1073/pnas.2135471100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Vincent Noireaux, Roy Bar-Ziv, and Albert Libchaber

Principles of cell-free genetic circuit assembly
PNAS 2003 100: 12672-12677; published online before print October 14 2003, 10.1073/pnas.2135496100 [Abstract] [Full Text] [PDF]  

Jack Schonbrun and Ken A. Dill

Fast protein folding kinetics
PNAS 2003 100: 12678-12682; published online before print October 20 2003, 10.1073/pnas.1735417100 [Abstract] [Full Text] [PDF]  

Sheh-Yi Sheu, Dah-Yen Yang, H. L. Selzle, and E. W. Schlag

Energetics of hydrogen bonds in peptides
PNAS 2003 100: 12683-12687; published online before print October 14 2003, 10.1073/pnas.2133366100 [Abstract] [Full Text] [PDF]  

Christiane A. Opitz, Michael Kulke, Mark C. Leake, Ciprian Neagoe, Horst Hinssen, Roger J. Hajjar, and Wolfgang A. Linke

Damped elastic recoil of the titin spring in myofibrils of human myocardium
PNAS 2003 100: 12688-12693; published online before print October 16 2003, 10.1073/pnas.2133733100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kylie J. Walters, Patrycja J. Lech, Amanda M. Goh, Qinghua Wang, and Peter M. Howley

DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a
PNAS 2003 100: 12694-12699; published online before print October 13 2003, 10.1073/pnas.1634989100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Oscar Millet, Rhea P. Hudson, and Lewis E. Kay From the Cover: The energetic cost of domain reorientation in maltose-binding protein as studied by NMR and fluorescence spectroscopy PNAS 2003 100: 12700-12705; published online before print October 6 2003, 10.1073/pnas.2134311100 [Abstract] [Full Text] [PDF]   See Commentary on page 12529

José Luis Vázquez-Ibar, Lan Guan, Maja Svrakic, and H. Ronald Kaback

Exploiting luminescence spectroscopy to elucidate the interaction between sugar and a tryptophan residue in the lactose permease of Escherichia coli
PNAS 2003 100: 12706-12711; published online before print October 17 2003, 10.1073/pnas.1835645100 [Abstract] [Full Text] [PDF]  

Cell Biology

Yang Hong, Larry Ackerman, Lily Yeh Jan, and Yuh-Nung Jan

Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture
PNAS 2003 100: 12712-12717; published online before print October 20 2003, 10.1073/pnas.2135347100 [Abstract] [Full Text] [PDF]  

Yu-Wen Zhang, Yanli Su, Olga V. Volpert, and George F. Vande Woude

Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
PNAS 2003 100: 12718-12723; published online before print October 10 2003, 10.1073/pnas.2135113100 [Abstract] [Full Text] [PDF]  

Kerwyn Casey Huang, Yigal Meir, and Ned S. Wingreen

Dynamic structures in Escherichia coli: Spontaneous formation of MinE rings and MinD polar zones
PNAS 2003 100: 12724-12728; published online before print October 20 2003, 10.1073/pnas.2135445100 [Abstract] [Full Text] [PDF]  

Yunyun Su, Shinji Ishikawa, Masayuki Kojima, and Bo Liu

Eradication of pathogenic -catenin by Skp1/Cullin/F box ubiquitination machinery
PNAS 2003 100: 12729-12734; published online before print October 16 2003, 10.1073/pnas.2133261100 [Abstract] [Full Text] [PDF]  

Amy L. Hitchcock, Kathryn Auld, Steven P. Gygi, and Pamela A. Silver

A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery
PNAS 2003 100: 12735-12740; published online before print October 13 2003, 10.1073/pnas.2135500100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Developmental Biology

Shulamit Levenberg, Ngan F. Huang, Erin Lavik, Arlin B. Rogers, Joseph Itskovitz-Eldor, and Robert Langer

Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds
PNAS 2003 100: 12741-12746; published online before print October 15 2003, 10.1073/pnas.1735463100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Gonçalo Castelo-Branco, Joseph Wagner, Francisco J. Rodriguez, Julianna Kele, Kyle Sousa, Nina Rawal, Hilda Amalia Pasolli, Elaine Fuchs, Jan Kitajewski, and Ernest Arenas

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
PNAS 2003 100: 12747-12752; published online before print October 13 2003, 10.1073/pnas.1534900100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mira C. Puri and Alan Bernstein

Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis
PNAS 2003 100: 12753-12758; published online before print October 6 2003, 10.1073/pnas.2133552100 [Abstract] [Full Text] [PDF]  

Yao Yao, Wei Li, Junwei Wu, Ursula A. Germann, Michael S. S. Su, Keisuke Kuida, and Diane M. Boucher

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
PNAS 2003 100: 12759-12764; published online before print October 17 2003, 10.1073/pnas.2134254100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ecology

Michel Loreau, Nicolas Mouquet, and Andrew Gonzalez

Biodiversity as spatial insurance in heterogeneous landscapes
PNAS 2003 100: 12765-12770; published online before print October 20 2003, 10.1073/pnas.2235465100 [Abstract] [Full Text] [PDF]  

Frederic Bartumeus, Francesc Peters, Salvador Pueyo, Cèlia Marrasé, and Jordi Catalan

Helical Lévy walks: Adjusting searching statistics to resource availability in microzooplankton
PNAS 2003 100: 12771-12775; published online before print October 17 2003, 10.1073/pnas.2137243100 [Abstract] [Full Text] [PDF]  

Jörg Tittel, Vera Bissinger, Barbara Zippel, Ursula Gaedke, Elanor Bell, Andreas Lorke, and Norbert Kamjunke

Mixotrophs combine resource use to outcompete specialists: Implications for aquatic food webs
PNAS 2003 100: 12776-12781; published online before print October 20 2003, 10.1073/pnas.2130696100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Evolution

Amy M. Suiter, Otmar Bänziger, and Antony M. Dean

Fitness consequences of a regulatory polymorphism in a seasonal environment
PNAS 2003 100: 12782-12786; published online before print October 10 2003, 10.1073/pnas.2134994100 [Abstract] [Full Text] [PDF]  

Abdel-Halim Salem, David A. Ray, Jinchuan Xing, Pauline A. Callinan, Jeremy S. Myers, Dale J. Hedges, Randall K. Garber, David J. Witherspoon, Lynn B. Jorde, and Mark A. Batzer

Alu elements and hominid phylogenetics
PNAS 2003 100: 12787-12791; published online before print October 15 2003, 10.1073/pnas.2133766100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Juan Carlos Santos, Luis A. Coloma, and David C. Cannatella From the Cover: Multiple, recurring origins of aposematism and diet specialization in poison frogs PNAS 2003 100: 12792-12797; published online before print October 10 2003, 10.1073/pnas.2133521100 [Abstract] [Full Text] [PDF] [Supporting Tables]   See Commentary on page 12533

Yohey Terai, Naoko Morikawa, Koichi Kawakami, and Norihiro Okada

The complexity of alternative splicing of hagoromo mRNAs is increased in an explosively speciated lineage in East African cichlids
PNAS 2003 100: 12798-12803; published online before print October 20 2003, 10.1073/pnas.2132833100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Judith X. Becerra

Synchronous coadaptation in an ancient case of herbivory
PNAS 2003 100: 12804-12807; published online before print October 10 2003, 10.1073/pnas.2133013100 [Abstract] [Full Text] [PDF]  

Barbara L. Thorne, Nancy L. Breisch, and Mario L. Muscedere

Evolution of eusociality and the soldier caste in termites: Influence of intraspecific competition and accelerated inheritance
PNAS 2003 100: 12808-12813; published online before print October 10 2003, 10.1073/pnas.2133530100 [Abstract] [Full Text] [PDF]  

Lena C. Hileman, Elena M. Kramer, and David A. Baum

Differential regulation of symmetry genes and the evolution of floral morphologies
PNAS 2003 100: 12814-12819; published online before print October 10 2003, 10.1073/pnas.1835725100 [Abstract] [Full Text] [PDF]  

Hong Qin, Henry H. S. Lu, Wei B. Wu, and Wen-Hsiung Li

Evolution of the yeast protein interaction network
PNAS 2003 100: 12820-12824; published online before print October 13 2003, 10.1073/pnas.2235584100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Storrs L. Olson and Paul J. Hearty

Probable extirpation of a breeding colony of Short-tailed Albatross (Phoebastria albatrus) on Bermuda by Pleistocene sea-level rise
PNAS 2003 100: 12825-12829; published online before print October 17 2003, 10.1073/pnas.1934576100 [Abstract] [Full Text] [PDF]  

José R. de la Torre, Lynne M. Christianson, Oded Béjà, Marcelino T. Suzuki, David M. Karl, John Heidelberg, and Edward F. DeLong

Proteorhodopsin genes are distributed among divergent marine bacterial taxa
PNAS 2003 100: 12830-12835; published online before print October 17 2003, 10.1073/pnas.2133554100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

A. Hartmann, J. Wantia, J. A. Torres, and J. Heinze

Worker policing without genetic conflicts in a clonal ant
PNAS 2003 100: 12836-12840; published online before print October 13 2003, 10.1073/pnas.2132993100 [Abstract] [Full Text] [PDF]  

Genetics

Catherine A. Dunn, Patrik Medstrand, and Dixie L. Mager

An endogenous retroviral long terminal repeat is the dominant promoter for human 1,3-galactosyltransferase 5 in the colon
PNAS 2003 100: 12841-12846; published online before print October 8 2003, 10.1073/pnas.2134464100 [Abstract] [Full Text] [PDF]  

E. Susan Slechta, Kim L. Bunny, Elisabeth Kugelberg, Eric Kofoid, Dan I. Andersson, and John R. Roth

Adaptive mutation: General mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac
PNAS 2003 100: 12847-12852; published online before print October 14 2003, 10.1073/pnas.1735464100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jason H. Bielas and John A. Heddle

Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells
PNAS 2003 100: 12853-12858; published online before print October 20 2003, 10.1073/pnas.2235595100 [Abstract] [Full Text] [PDF]  

Sugiko Watanabe, Takaya Ichimura, Naoyuki Fujita, Shu Tsuruzoe, Izuru Ohki, Masahiro Shirakawa, Michio Kawasuji, and Mitsuyoshi Nakao

Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression and DNA repair in chromatin
PNAS 2003 100: 12859-12864; published online before print October 10 2003, 10.1073/pnas.2131819100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sophie Tessé, Aurora Storlazzi, Nancy Kleckner, Silvana Gargano, and Denise Zickler

Localization and roles of Ski8p protein in Sordaria meiosis and delineation of three mechanistically distinct steps of meiotic homolog juxtaposition
PNAS 2003 100: 12865-12870; published online before print October 16 2003, 10.1073/pnas.2034282100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Michael M. Vilenchik and Alfred G. Knudson

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer
PNAS 2003 100: 12871-12876; published online before print October 17 2003, 10.1073/pnas.2135498100 [Abstract] [Full Text] [PDF] [Supporting Table]  

C. J. Willer, D. A. Dyment, N. J. Risch, A. D. Sadovnick, and G. C. Ebers

Twin concordance and sibling recurrence rates in multiple sclerosis
PNAS 2003 100: 12877-12882; published online before print October 20 2003, 10.1073/pnas.1932604100 [Abstract] [Full Text] [PDF]  

Immunology

Lars Hangartner, Beatrice M. Senn, Birgit Ledermann, Ulrich Kalinke, Peter Seiler, Etienne Bucher, Raphaël M. Zellweger, Katja Fink, Bernhard Odermatt, Kurt Bürki, Rolf M. Zinkernagel, and Hans Hengartner

Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies
PNAS 2003 100: 12883-12888; published online before print October 20 2003, 10.1073/pnas.2135542100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Anne L. Ackerman, Christoph Kyritsis, Robert Tampé, and Peter Cresswell

Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens
PNAS 2003 100: 12889-12894; published online before print October 15 2003, 10.1073/pnas.1735556100 [Abstract] [Full Text] [PDF]  

Tomonori Eto, Kazuo Kinoshita, Kiyotsugu Yoshikawa, Masamichi Muramatsu, and Tasuku Honjo

RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells
PNAS 2003 100: 12895-12898; published online before print October 14 2003, 10.1073/pnas.2135587100 [Abstract] [Full Text] [PDF]  

David M. Koelle, Zhi Liu, Christopher L. McClurkan, Randal C. Cevallos, Jeffrey Vieira, Nancy A. Hosken, Clement A. Meseda, Devon C. Snow, Anna Wald, and Lawrence Corey

Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
PNAS 2003 100: 12899-12904; published online before print October 17 2003, 10.1073/pnas.2131705100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Loren D. Erickson, Ling-Li Lin, Biyan Duan, Laurence Morel, and Randolph J. Noelle

A genetic lesion that arrests plasma cell homing to the bone marrow
PNAS 2003 100: 12905-12910; published online before print October 10 2003, 10.1073/pnas.2131686100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jiro Kitaura, Jinming Song, Mindy Tsai, Koichi Asai, Mari Maeda-Yamamoto, Attila Mocsai, Yuko Kawakami, Fu-Tong Liu, Clifford A. Lowell, B. George Barisas, Stephen J. Galli, and Toshiaki Kawakami

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcRI
PNAS 2003 100: 12911-12916; published online before print October 20 2003, 10.1073/pnas.1735525100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Medical Sciences

Guido Bocci, Giulio Francia, Shan Man, Jack Lawler, and Robert S. Kerbel

Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
PNAS 2003 100: 12917-12922; published online before print October 15 2003, 10.1073/pnas.2135406100 [Abstract] [Full Text] [PDF]  

Chang-Hyuk Kwon, Xiaoyan Zhu, Junyuan Zhang, and Suzanne J. Baker

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
PNAS 2003 100: 12923-12928; published online before print October 8 2003, 10.1073/pnas.2132711100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jörg J. Jacoby, April Kalinowski, Mu-Gen Liu, Samuel S.-M. Zhang, Qian Gao, Gui-Xuan Chai, Lan Ji, Yoshiki Iwamoto, En Li, Michael Schneider, Kerry S. Russell, and Xin-Yuan Fu

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age
PNAS 2003 100: 12929-12934; published online before print October 17 2003, 10.1073/pnas.2134694100 [Abstract] [Full Text] [PDF]  

Feng X. Li, Jing W. Zhu, Jeffery S. Tessem, Joshua Beilke, Marileila Varella-Garcia, Jan Jensen, Christopher J. Hogan, and James DeGregori

The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss
PNAS 2003 100: 12935-12940; published online before print October 17 2003, 10.1073/pnas.2231861100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shuren Ma, Seymour Lieberman, Gerard M. Turino, and Yong Y. Lin

The detection and quantitation of free desmosine and isodesmosine in human urine and their peptide-bound forms in sputum
PNAS 2003 100: 12941-12943; published online before print October 16 2003, 10.1073/pnas.2235344100 [Abstract] [Full Text] [PDF]  

Yana Zavros, Sivaprakash Rathinavelu, John Y. Kao, Andrea Todisco, John Del Valle, Joel V. Weinstock, Malcolm J. Low, and Juanita L. Merchant

Treatment of Helicobacter gastritis with IL-4 requires somatostatin
PNAS 2003 100: 12944-12949; published online before print October 10 2003, 10.1073/pnas.2135193100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Regine Choe, Turgut Durduran, Guoqiang Yu, Mark J. M. Nijland, Britton Chance, Arjun G. Yodh, and Nirmala Ramanujam

Transabdominal near infrared oximetry of hypoxic stress in fetal sheep brain in utero
PNAS 2003 100: 12950-12954; published online before print October 16 2003, 10.1073/pnas.1735462100 [Abstract] [Full Text] [PDF]  

David G. Brooks, Philip A. Arlen, Lianying Gao, Christina M. R. Kitchen, and Jerome A. Zack

Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
PNAS 2003 100: 12955-12960; published online before print October 20 2003, 10.1073/pnas.2233345100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Georgia L. Wiesner, Denise Daley, Susan Lewis, Christine Ticknor, Petra Platzer, James Lutterbaugh, Melissa MacMillen, Boris Baliner, Joseph Willis, Robert C. Elston, and Sanford D. Markowitz

A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2
PNAS 2003 100: 12961-12965; published online before print October 17 2003, 10.1073/pnas.2132286100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Anna Richards, Elizabeth J. Kemp, M. Kathryn Liszewski, Judith A. Goodship, Anne K. Lampe, Ronny Decorte, M. Hamza Müslümanogglu, Salih Kavukcu, Guido Filler, Yves Pirson, Leana S. Wen, John P. Atkinson, and Timothy H. J. Goodship

Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome
PNAS 2003 100: 12966-12971; published online before print October 17 2003, 10.1073/pnas.2135497100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Kimdar Sherefa Kemal, Brian Foley, Harold Burger, Kathryn Anastos, Howard Minkoff, Christina Kitchen, Sean M. Philpott, Wei Gao, Esther Robison, Susan Holman, Carolyn Dehner, Suzanne Beck, William A. Meyer, III, Alan Landay, Andrea Kovacs, James Bremer, and Barbara Weiser

HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation
PNAS 2003 100: 12972-12977; published online before print October 13 2003, 10.1073/pnas.2134064100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Mar Perez, Rebecca C. Craven, and Juan C. de la Torre

The small RING finger protein Z drives arenavirus budding: Implications for antiviral strategies
PNAS 2003 100: 12978-12983; published online before print October 16 2003, 10.1073/pnas.2133782100 [Abstract] [Full Text] [PDF]  

Elizabeth Waters, Michael J. Hohn, Ivan Ahel, David E. Graham, Mark D. Adams, Mary Barnstead, Karen Y. Beeson, Lisa Bibbs, Randall Bolanos, Martin Keller, Keith Kretz, Xiaoying Lin, Eric Mathur, Jingwei Ni, Mircea Podar, Toby Richardson, Granger G. Sutton, Melvin Simon, Dieter Söll, Karl O. Stetter, Jay M. Short, and Michiel Noordewier

The genome of Nanoarchaeum equitans: Insights into early archaeal evolution and derived parasitism
PNAS 2003 100: 12984-12988; published online before print October 17 2003, 10.1073/pnas.1735403100 [Abstract] [Full Text] [PDF] [Supporting Data Set]  

Christopher M. Sassetti and Eric J. Rubin

Genetic requirements for mycobacterial survival during infection
PNAS 2003 100: 12989-12994; published online before print October 20 2003, 10.1073/pnas.2134250100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Boyd Yount, Kristopher M. Curtis, Elizabeth A. Fritz, Lisa E. Hensley, Peter B. Jahrling, Erik Prentice, Mark R. Denison, Thomas W. Geisbert, and Ralph S. Baric

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
PNAS 2003 100: 12995-13000; published online before print October 20 2003, 10.1073/pnas.1735582100 [Abstract] [Full Text] [PDF]  

Sarah A. Stanley, Sridharan Raghavan, William W. Hwang, and Jeffery S. Cox

Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
PNAS 2003 100: 13001-13006; published online before print October 13 2003, 10.1073/pnas.2235593100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sylvie Gratepanche, Benoit Gamain, Joseph D. Smith, Bridget A. Robinson, Allan Saul, and Louis H. Miller

Induction of crossreactive antibodies against the Plasmodium falciparum variant protein
PNAS 2003 100: 13007-13012; published online before print October 20 2003, 10.1073/pnas.2235588100 [Abstract] [Full Text] [PDF]  

Sandra Blaise, Nathalie de Parseval, Laurence Bénit, and Thierry Heidmann

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution
PNAS 2003 100: 13013-13018; published online before print October 13 2003, 10.1073/pnas.2132646100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Candice E. Junge, Taku Sugawara, Guido Mannaioni, Sudar Alagarsamy, P. Jeffrey Conn, Daniel J. Brat, Pak H. Chan, and Stephen F. Traynelis

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia
PNAS 2003 100: 13019-13024; published online before print October 14 2003, 10.1073/pnas.2235594100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Lunbin Deng and Gong Chen

Cyclothiazide potently inhibits -aminobutyric acid type A receptors in addition to enhancing glutamate responses
PNAS 2003 100: 13025-13029; published online before print October 8 2003, 10.1073/pnas.2133370100 [Abstract] [Full Text] [PDF]  

Mario Cáceres, Joel Lachuer, Matthew A. Zapala, John C. Redmond, Lili Kudo, Daniel H. Geschwind, David J. Lockhart, Todd M. Preuss, and Carrolee Barlow

Elevated gene expression levels distinguish human from non-human primate brains
PNAS 2003 100: 13030-13035; published online before print October 13 2003, 10.1073/pnas.2135499100 [Abstract] [Full Text] [PDF] [Supporting Information]  

F. Luzzati, P. Peretto, P. Aimar, G. Ponti, A. Fasolo, and L. Bonfanti

Glia-independent chains of neuroblasts through the subcortical parenchyma of the adult rabbit brain
PNAS 2003 100: 13036-13041; published online before print October 14 2003, 10.1073/pnas.1735482100 [Abstract] [Full Text] [PDF]  

Maaria Ikonen, Bingrong Liu, Yuichi Hashimoto, Liqun Ma, Kuk-Wha Lee, Takako Niikura, Ikuo Nishimoto, and Pinchas Cohen

Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis
PNAS 2003 100: 13042-13047; published online before print October 15 2003, 10.1073/pnas.2135111100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Josh Syken and Carla J. Shatz

Expression of T cell receptor locus in central nervous system neurons
PNAS 2003 100: 13048-13053; published online before print October 20 2003, 10.1073/pnas.1735415100 [Abstract] [Full Text]