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EDITORIAL

Nicholas R. Cozzarelli, Kenneth R. Fulton, Diane M. Sullenberger, and Bridget C. Coughlin

Biographies of newly elected Academy members
PNAS 2003 100: 13117; published online before print November 3 2003, 10.1073/pnas.2536811100 [Extract] [Full Text] [PDF]  

COMMENTARIES

Dafna Nathan, David E. Sterner, and Shelley L. Berger

Histone modifications: Now summoning sumoylation
PNAS 2003 100: 13118-13120; published online before print November 3 2003, 10.1073/pnas.2436173100 [Extract] [Full Text] [PDF]  
See companion article on page 13225

Thomas L. Poulos

Cytochrome P450 flexibility
PNAS 2003 100: 13121-13122; published online before print November 3 2003, 10.1073/pnas.2336095100 [Extract] [Full Text] [PDF]  
See companion article on page 13196

Larry Cahill

Similar neural mechanisms for emotion-induced memory impairment and enhancement
PNAS 2003 100: 13123-13124; published online before print November 4 2003, 10.1073/pnas.2335833100 [Extract] [Full Text] [PDF]  
See companion article on page 13626

PHYSICAL SCIENCES

Applied Mathematics

Iman Famili, Jochen Förster, Jens Nielsen, and Bernhard O. Palsson

Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network
PNAS 2003 100: 13134-13139; published online before print October 24 2003, 10.1073/pnas.2235812100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chemistry

Michael M. Rosenblatt, Jiangyun Wang, and Kenneth S. Suslick

De novo designed cyclic-peptide heme complexes
PNAS 2003 100: 13140-13145; published online before print October 31 2003, 10.1073/pnas.2231273100 [Abstract] [Full Text] [PDF]  

Johan Hofkens, Mircea Cotlet, Tom Vosch, Philip Tinnefeld, Kenneth D. Weston, Christophe Ego, Andrew Grimsdale, Klaus Müllen, David Beljonne, Jean Luc Brédas, Sven Jordens, Gerd Schweitzer, Markus Sauer, and Frans De Schryver

Revealing competitive Förster-type resonance energy-transfer pathways in single bichromophoric molecules
PNAS 2003 100: 13146-13151; published online before print October 28 2003, 10.1073/pnas.2235805100 [Abstract] [Full Text] [PDF]  

Engineering

Shunichi Fukuda and Geert W. Schmid-Schönbein

Regulation of CD18 expression on neutrophils in response to fluid shear stress
PNAS 2003 100: 13152-13157; published online before print October 31 2003, 10.1073/pnas.2336130100 [Abstract] [Full Text] [PDF]  

Geophysics

P. C. D. Milly, A. Cazenave, and C. Gennero

Contribution of climate-driven change in continental water storage to recent sea-level rise
PNAS 2003 100: 13158-13161; published online before print October 23 2003, 10.1073/pnas.2134014100 [Abstract] [Full Text] [PDF]  

Physics

Navin Khaneja, Burkhard Luy, and Steffen J. Glaser

Boundary of quantum evolution under decoherence
PNAS 2003 100: 13162-13166; published online before print October 31 2003, 10.1073/pnas.2134111100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Statistics

Li Liu, Douglas M. Hawkins, Sujoy Ghosh, and S. Stanley Young

Robust singular value decomposition analysis of microarray data
PNAS 2003 100: 13167-13172; published online before print October 27 2003, 10.1073/pnas.1733249100 [Abstract] [Full Text] [PDF] [Supporting Information]  

SOCIAL SCIENCES

Anthropology

Laurent Marivaux, Yaowalak Chaimanee, Stéphane Ducrocq, Bernard Marandat, Jean Sudre, Aung Naing Soe, Soe Thura Tun, Wanna Htoon, and Jean-Jacques Jaeger

The anthropoid status of a primate from the late middle Eocene Pondaung Formation (Central Myanmar): Tarsal evidence
PNAS 2003 100: 13173-13178; published online before print October 31 2003, 10.1073/pnas.2332542100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Psychology

Stanislas Dehaene, Eric Artiges, Lionel Naccache, Catherine Martelli, Armelle Viard, Franck Schürhoff, Christophe Recasens, Marie Laure Paillère Martinot, Marion Leboyer, and Jean-Luc Martinot

Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: The role of the anterior cingulate
PNAS 2003 100: 13722-13727; published online before print November 3 2003, 10.1073/pnas.2235214100 [Abstract] [Full Text] [PDF] [SupportingTable]  

Lars Nyberg, Johan Sandblom, Sari Jones, Anna Stigsdotter Neely, Karl Magnus Petersson, Martin Ingvar, and Lars Bäckman

Neural correlates of training-related memory improvement in adulthood and aging
PNAS 2003 100: 13728-13733; published online before print November 3 2003, 10.1073/pnas.1735487100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Biochemistry

Christine M. Angevine, Kelly A. G. Herold, and Robert H. Fillingame

Aqueous access pathways in subunit a of rotary ATP synthase extend to both sides of the membrane
PNAS 2003 100: 13179-13183; published online before print October 31 2003, 10.1073/pnas.2234364100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Dirk Hoffmeister, Jie Yang, Lesley Liu, and Jon S. Thorson

Creation of the first anomeric D/L-sugar kinase by means of directed evolution
PNAS 2003 100: 13184-13189; published online before print October 31 2003, 10.1073/pnas.2235011100 [Abstract] [Full Text] [PDF]  

Haitao Yang, Maojun Yang, Yi Ding, Yiwei Liu, Zhiyong Lou, Zhe Zhou, Lei Sun, Lijuan Mo, Sheng Ye, Hai Pang, George F. Gao, Kanchan Anand, Mark Bartlam, Rolf Hilgenfeld, and Zihe Rao

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
PNAS 2003 100: 13190-13195; published online before print October 29 2003, 10.1073/pnas.1835675100 [Abstract] [Full Text] [PDF]  

Emily E. Scott, You Ai He, Michael R. Wester, Mark A. White, Christopher C. Chin, James R. Halpert, Eric F. Johnson, and C. David Stout From The Cover: An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution PNAS 2003 100: 13196-13201; published online before print October 16 2003, 10.1073/pnas.2133986100 [Abstract] [Full Text] [PDF]   See Commentary on page 13121

Daniel Christ and Greg Winter

Identification of functional similarities between proteins using directed evolution
PNAS 2003 100: 13202-13206; published online before print October 22 2003, 10.1073/pnas.2134365100 [Abstract] [Full Text] [PDF]  

Albert Sickmann, Jörg Reinders, Yvonne Wagner, Cornelia Joppich, René Zahedi, Helmut E. Meyer, Birgit Schönfisch, Inge Perschil, Agnieszka Chacinska, Bernard Guiard, Peter Rehling, Nikolaus Pfanner, and Chris Meisinger

The proteome of Saccharomyces cerevisiae mitochondria
PNAS 2003 100: 13207-13212; published online before print October 23 2003, 10.1073/pnas.2135385100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Yong Li and Sidney Altman

A specific endoribonuclease, RNase P, affects gene expression of polycistronic operon mRNAs
PNAS 2003 100: 13213-13218; published online before print October 29 2003, 10.1073/pnas.2235589100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Saskia B. Neher, Robert T. Sauer, and Tania A. Baker

Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease
PNAS 2003 100: 13219-13224; published online before print October 31 2003, 10.1073/pnas.2235804100 [Abstract] [Full Text] [PDF]  

Yuzuru Shiio and Robert N. Eisenman From The Cover: Histone sumoylation is associated with transcriptional repression PNAS 2003 100: 13225-13230; published online before print October 24 2003, 10.1073/pnas.1735528100 [Abstract] [Full Text] [PDF]   See Commentary on page 13118

Markus Eser and Michael Ehrmann

SecA-dependent quality control of intracellular protein localization
PNAS 2003 100: 13231-13234; published online before print November 3 2003, 10.1073/pnas.2234410100 [Abstract] [Full Text] [PDF]  

Stéphane Duvezin-Caubet, Matthieu Caron, Marie-France Giraud, Jean Velours, and Jean-Paul di Rago

The two rotor components of yeast mitochondrial ATP synthase are mechanically coupled by subunit
PNAS 2003 100: 13235-13240; published online before print October 27 2003, 10.1073/pnas.2135169100 [Abstract] [Full Text] [PDF]  

Tatyana A. Prokhorova, Karen Mowrer, Catherine H. Gilbert, and Johannes C. Walter

DNA replication of mitotic chromatin in Xenopus egg extracts
PNAS 2003 100: 13241-13246; published online before print November 3 2003, 10.1073/pnas.2336104100 [Abstract] [Full Text] [PDF]  

Edith H. Postel and Bozena M. Abramczyk

Escherichia coli nucleoside diphosphate kinase is a uracil-processing DNA repair nuclease
PNAS 2003 100: 13247-13252; published online before print October 29 2003, 10.1073/pnas.2333230100 [Abstract] [Full Text] [PDF]  

Yasser Bustanji, Carla Renata Arciola, Matteo Conti, Enrico Mandello, Lucio Montanaro, and Bruno Samorí

Dynamics of the interaction between a fibronectin molecule and a living bacterium under mechanical force
PNAS 2003 100: 13292-13297; published online before print October 22 2003, 10.1073/pnas.1735343100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Biophysics

Wenjun Zheng and Sebastian Doniach

A comparative study of motor-protein motions by using a simple elastic-network model
PNAS 2003 100: 13253-13258; published online before print October 29 2003, 10.1073/pnas.2235686100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Nikhil Mittal, Elena O. Budrene, Michael P. Brenner, and Alexander van Oudenaarden

Motility of Escherichia coli cells in clusters formed by chemotactic aggregation
PNAS 2003 100: 13259-13263; published online before print November 3 2003, 10.1073/pnas.2233626100 [Abstract] [Full Text] [PDF]  

Ganesh S. Anand, Dennis Law, Jeffrey G. Mandell, Aaron N. Snead, Igor Tsigelny, Susan S. Taylor, Lynn F. Ten Eyck, and Elizabeth A. Komives

Identification of the protein kinase A regulatory R^I-catalytic subunit interface by amide H/²H exchange and protein docking
PNAS 2003 100: 13264-13269; published online before print October 28 2003, 10.1073/pnas.2232255100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Yinan Wei, Seho Kim, David Fela, Jean Baum, and Michael H. Hecht

Solution structure of a de novo protein from a designed combinatorial library
PNAS 2003 100: 13270-13273; published online before print October 30 2003, 10.1073/pnas.1835644100 [Abstract] [Full Text] [PDF]  

Julia M. Shifman and Stephen L. Mayo

Exploring the origins of binding specificity through the computational redesign of calmodulin
PNAS 2003 100: 13274-13279; published online before print November 3 2003, 10.1073/pnas.2234277100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Ruhong Zhou

Trp-cage: Folding free energy landscape in explicit water
PNAS 2003 100: 13280-13285; published online before print October 27 2003, 10.1073/pnas.2233312100 [Abstract] [Full Text] [PDF]  

Stefano Gianni, Nicholas R. Guydosh, Faaizah Khan, Teresa D. Caldas, Ugo Mayor, George W. N. White, Mari L. DeMarco, Valerie Daggett, and Alan R. Fersht

Unifying features in protein-folding mechanisms
PNAS 2003 100: 13286-13291; published online before print October 31 2003, 10.1073/pnas.1835776100 [Abstract] [Full Text] [PDF]  

Yasser Bustanji, Carla Renata Arciola, Matteo Conti, Enrico Mandello, Lucio Montanaro, and Bruno Samorí

Dynamics of the interaction between a fibronectin molecule and a living bacterium under mechanical force
PNAS 2003 100: 13292-13297; published online before print October 22 2003, 10.1073/pnas.1735343100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Cell Biology

Elena G. Arias-Salgado, Sergio Lizano, Sugata Sarkar, Joan S. Brugge, Mark H. Ginsberg, and Sanford J. Shattil

Src kinase activation by direct interaction with the integrin cytoplasmic domain
PNAS 2003 100: 13298-13302; published online before print October 30 2003, 10.1073/pnas.2336149100 [Abstract] [Full Text] [PDF]  

Natalia Issaeva, Assaf Friedler, Przemyslaw Bozko, Klas G. Wiman, Alan R. Fersht, and Galina Selivanova

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
PNAS 2003 100: 13303-13307; published online before print October 31 2003, 10.1073/pnas.1835733100 [Abstract] [Full Text] [PDF]  

Diana P. Bratu, Byeong-Jik Cha, Musa M. Mhlanga, Fred Russell Kramer, and Sanjay Tyagi

Visualizing the distribution and transport of mRNAs in living cells
PNAS 2003 100: 13308-13313; published online before print October 28 2003, 10.1073/pnas.2233244100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Nihal Altan-Bonnet, Robert D. Phair, Roman S. Polishchuk, Roberto Weigert, and Jennifer Lippincott-Schwartz

A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis
PNAS 2003 100: 13314-13319; published online before print October 29 2003, 10.1073/pnas.2234055100 [Abstract] [Full Text] [PDF] [Supporting Information]  

John T. R. Lawrence and Morris J. Birnbaum

ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate
PNAS 2003 100: 13320-13325; published online before print October 29 2003, 10.1073/pnas.2232129100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Benoît Schneider, Vincent Mutel, Mathéa Pietri, Myriam Ermonval, Sophie Mouillet-Richard, and Odile Kellermann

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells
PNAS 2003 100: 13326-13331; published online before print November 3 2003, 10.1073/pnas.2235648100 [Abstract] [Full Text] [PDF]  

J. L. A. N. Murk, B. M. Humbel, U. Ziese, J. M. Griffith, G. Posthuma, J. W. Slot, A. J. Koster, A. J. Verkleij, H. J. Geuze, and M. J. Kleijmeer

Endosomal compartmentalization in three dimensions: Implications for membrane fusion
PNAS 2003 100: 13332-13337; published online before print November 3 2003, 10.1073/pnas.2232379100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Developmental Biology

Jinsong Zhu, Li Chen, and Alexander S. Raikhel

Posttranscriptional control of the competence factor FTZ-F1 by juvenile hormone in the mosquito Aedes aegypti
PNAS 2003 100: 13338-13343; published online before print October 30 2003, 10.1073/pnas.2234416100 [Abstract] [Full Text] [PDF]  

Lidia Hernandez, Serguei Kozlov, Graziella Piras, and Colin L. Stewart From The Cover: Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation PNAS 2003 100: 13344-13349; published online before print October 27 2003, 10.1073/pnas.2234026100 [Abstract] [Full Text] [PDF]

Jamie M. Sperger, Xin Chen, Jonathan S. Draper, Jessica E. Antosiewicz, Chris H. Chon, Sunita B. Jones, James D. Brooks, Peter W. Andrews, Patrick O. Brown, and James A. Thomson

Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
PNAS 2003 100: 13350-13355; published online before print October 31 2003, 10.1073/pnas.2235735100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Veronica F. Hinman, Albert T. Nguyen, R. Andrew Cameron, and Eric H. Davidson

Developmental gene regulatory network architecture across 500 million years of echinoderm evolution
PNAS 2003 100: 13356-13361; published online before print October 31 2003, 10.1073/pnas.2235868100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Wim de Graaff, Daihachiro Tomotsune, Tony Oosterveen, Yoshihiro Takihara, Haruhiko Koseki, and Jacqueline Deschamps

Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants
PNAS 2003 100: 13362-13367; published online before print October 31 2003, 10.1073/pnas.2237046100 [Abstract] [Full Text] [PDF]  

Julia Serano and Gerald M. Rubin

The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame
PNAS 2003 100: 13368-13373; published online before print October 27 2003, 10.1073/pnas.1835727100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Geoffrey M. Attardo, Stephen Higgs, Kimberley A. Klingler, Dana L. Vanlandingham, and Alexander S. Raikhel

RNA interference-mediated knockdown of a GATA factor reveals a link to anautogeny in the mosquito Aedes aegypti
PNAS 2003 100: 13374-13379; published online before print October 31 2003, 10.1073/pnas.2235649100 [Abstract] [Full Text] [PDF]  

Ecology

Paul Alan Cox, Sandra Anne Banack, and Susan J. Murch

Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam
PNAS 2003 100: 13380-13383. [Abstract] [Full Text] [PDF]  

Eric W. Seabloom, W. Stanley Harpole, O. J. Reichman, and David Tilman

Invasion, competitive dominance, and resource use by exotic and native California grassland species
PNAS 2003 100: 13384-13389; published online before print October 31 2003, 10.1073/pnas.1835728100 [Abstract] [Full Text] [PDF]  

Evolution

Eileen A. Hebets

Subadult experience influences adult mate choice in an arthropod: Exposed female wolf spiders prefer males of a familiar phenotype
PNAS 2003 100: 13390-13395; published online before print November 3 2003, 10.1073/pnas.2333262100 [Abstract] [Full Text] [PDF]  

Claire C. Milton, Brandon Huynh, Philip Batterham, Suzanne L. Rutherford, and Ary A. Hoffmann

Quantitative trait symmetry independent of Hsp90 buffering: Distinct modes of genetic canalization and developmental stability
PNAS 2003 100: 13396-13401; published online before print October 31 2003, 10.1073/pnas.1835613100 [Abstract] [Full Text] [PDF]  

Peter D. Keightley and Daniel J. Gaffney

Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents
PNAS 2003 100: 13402-13406; published online before print November 3 2003, 10.1073/pnas.2233252100 [Abstract] [Full Text] [PDF]  

León Patricio Martínez-Castilla and Elena R. Alvarez-Buylla

Adaptive evolution in the Arabidopsis MADS-box gene family inferred from its complete resolved phylogeny
PNAS 2003 100: 13407-13412; published online before print November 3 2003, 10.1073/pnas.1835864100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Francisco Rodríguez-Trelles, Rosa Tarrío, and Francisco J. Ayala

Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene
PNAS 2003 100: 13413-13417; published online before print October 23 2003, 10.1073/pnas.1835646100 [Abstract] [Full Text] [PDF]  

Genetics

Helena Brentani, Otávia L. Caballero, Anamaria A. Camargo, Aline M. da Silva, Wilson Araújo da Silva, Jr., Emmanuel Dias Neto, Marco Grivet, Arthur Gruber, Pedro Edson Moreira Guimaraes, Winston Hide, Christian Iseli, C. Victor Jongeneel, Janet Kelso, Maria Aparecida Nagai, Elida Paula Benquique Ojopi, Elisson C. Osorio, Eduardo M. R. Reis, Gregory J. Riggins, Andrew John George Simpson, Sandro de Souza, Brian J. Stevenson, Robert L. Strausberg, Eloiza H. Tajara, Sergio Verjovski-Almeida, The Human Cancer Genome Project/Cancer Genome Anatomy Project Annotation Consortium, Marcio Luis Acencio, Mário Henrique Bengtson, Fabiana Bettoni, Walter F. Bodmer, Marcelo R. S. Briones, Luiz Paulo Camargo, Webster Cavenee, Janete M. Cerutti, Luís Eduardo Coelho Andrade, Paulo César Costa dos Santos, Maria Cristina Ramos Costa, Israel Tojal da Silva, Marcos Roberto H. Estécio, Karine Sa Ferreira, Frank B. Furnari, Milton Faria, Jr., Pedro A. F. Galante, Gustavo S. Guimaraes, Adriano Jesus Holanda, Edna Teruko Kimura, Maarten R Leerkes, Xin Lu, Rui M. B. Maciel, Elizabeth A. L. Martins, Katlin Brauer Massirer, Analy S. A. Melo, Carlos Alberto Mestriner, Elisabete Cristina Miracca, Leandro Lorenco Miranda, Francisco G. Nobrega, Paulo S. Oliveira, Apuã C. M. Paquola, José Rodrigo C. Pandolfi, Maria Inês de Moura Campos Pardini, Fabio Passetti, John Quackenbush, Beatriz Schnabel, Mari Cleide Sogayar, Jorge E. Souza, Sandro R. Valentini, Andre C. Zaiats, The Human Cancer Genome Project Sequencing Consortium, Elisabete Jorge Amaral, Liliane A. T. Arnaldi, Amélia Goes de Araújo, Simone Aparecida de Bessa, David C. Bicknell, Maria Eugenia Ribeiro de Camaro, Dirce Maria Carraro, Helaine Carrer, Alex F. Carvalho, Christian Colin, Fernando Costa, Cyntia Curcio, Ismael Dale Cotrim Guerreiro da Silva, Neusa Pereira da Silva, Márcia Dellamano, Hamza El-Dorry, Enilza Maria Espreafico, Ari José Scattone Ferreira, Cristiane Ayres Ferreira, Maria Angela H. Z. Fortes, Angelita Habr Gama, Daniel Giannella-Neto, Maria Lúcia C. C. Giannella, Ricardo R. Giorgi, Gustavo Henrique Goldman, Maria Helena S. Goldman, Christine Hackel, Paulo Lee Ho, Elza Myiuki Kimura, Luiz Paulo Kowalski, Jose E. Krieger, Luciana C. C. Leite, Ademar Lopes, Ana Mercedes S. C. Luna, Alan Mackay, Suely Kazue Nagahashi Mari, Adriana Aparecida Marques, Waleska K. Martins, André Montagnini, Mario Mourão Neto, Ana Lucia T. O. Nascimento, A. Munro Neville, Marina P. Nobrega, Mike J. O’Hare, Audrey Yumi Otsuka, Anna Izabel Ruas de Melo, Maria Luisa Paçó-Larson, Gonçalo Guimarães Pereira, Neusa Pereira da Silva, João Bosco Pesquero, Juliana Gilbert Pessoa, Paula Rahal, Claudia Aparecida Rainho, Vanderlei Rodrigues, Silvia Regina Rogatto, Camila Malta Romano, Janaína Gusmão Romeiro, Benedito Mauro Rossi, Monica Rusticci, Renata Guerra de Sá, Simone Cristina Sant’ Anna, Míriam L. Sarmazo, Teresa Cristina de Lima e Silva, Fernando Augusto Soares, Maria de Fátima Sonati, Josane de Freitas Sousa, Diana Queiroz, Valéria Valente, André Luiz Vettore, Fabiola Elizabeth Villanova, Marco Antonio Zago, and Heloisa Zalcberg

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags
PNAS 2003 100: 13418-13423; published online before print October 30 2003, 10.1073/pnas.1233632100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Erich Roessler, Yang-Zhu Du, Jose L. Mullor, Esther Casas, William P. Allen, Gabriele Gillessen-Kaesbach, Elizabeth R. Roeder, Jeffrey E. Ming, Ariel Ruiz i Altaba, and Maximilian Muenke

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
PNAS 2003 100: 13424-13429; published online before print October 27 2003, 10.1073/pnas.2235734100 [Abstract] [Full Text] [PDF]  

Jonathan Gallant, Paul Bonthuis, and Dale Lindsley

Evidence that the bypassing ribosome travels through the coding gap
PNAS 2003 100: 13430-13435; published online before print October 23 2003, 10.1073/pnas.2233745100 [Abstract] [Full Text] [PDF]  

Timothy J. Parnell, Michaela M. Viering, Astrid Skjesol, Cecilia Helou, Emily J. Kuhn, and Pamela K. Geyer

An endogenous Suppressor of Hairy-wing insulator separates regulatory domains in Drosophila
PNAS 2003 100: 13436-13441; published online before print November 3 2003, 10.1073/pnas.2333111100 [Abstract] [Full Text] [PDF]  

Andrew P. Morris, John C. Whittaker, Chun-Fang Xu, Louise K. Hosking, and David J. Balding

Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity
PNAS 2003 100: 13442-13446; published online before print November 3 2003, 10.1073/pnas.2235031100 [Abstract] [Full Text] [PDF]  

Immunology

John F. Elliott, Junliang Liu, Zuan-Ning Yuan, Norma Bautista-Lopez, Sarah L. Wallbank, Kunimasa Suzuki, David Rayner, Patrick Nation, Murray A. Robertson, Gang Liu, and Katherine M. Kavanagh

Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IA knockout NOD mice
PNAS 2003 100: 13447-13452; published online before print October 21 2003, 10.1073/pnas.2235552100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Raj Deonarain, Amit Verma, Andrew C. G. Porter, Dirk R. Gewert, Leonidas C. Platanias, and Eleanor N. Fish

Critical roles for IFN- in lymphoid development, myelopoiesis, and tumor development: Links to tumor necrosis factor
PNAS 2003 100: 13453-13458; published online before print November 3 2003, 10.1073/pnas.2230460100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Robert Berland and Henry H. Wortis

Normal B-1a cell development requires B cell-intrinsic NFATc1 activity
PNAS 2003 100: 13459-13464; published online before print October 31 2003, 10.1073/pnas.2233620100 [Abstract] [Full Text] [PDF]  

Chun Jeih Ryu, Brian B. Haines, Dobrin D. Draganov, Yun Hee Kang, Charles E. Whitehurst, Tara Schmidt, Hyo Jeong Hong, and Jianzhu Chen

The T cell receptor enhancer promotes access and pairing of D and J gene segments during V(D)J recombination
PNAS 2003 100: 13465-13470; published online before print October 30 2003, 10.1073/pnas.2235807100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Stefan O. Schönland, Consuelo Lopez, Thomas Widmann, Julia Zimmer, Ewa Bryl, Jörg J. Goronzy, and Cornelia M. Weyand

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages
PNAS 2003 100: 13471-13476; published online before print October 24 2003, 10.1073/pnas.2233561100 [Abstract] [Full Text] [PDF]  

Stefan Freigang, Denise Egger, Kurt Bienz, Hans Hengartner, and Rolf M. Zinkernagel

Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming
PNAS 2003 100: 13477-13482; published online before print October 31 2003, 10.1073/pnas.1835685100 [Abstract] [Full Text] [PDF]  

Valentina Voigt, Catherine A. Forbes, Joanne N. Tonkin, Mariapia A. Degli-Esposti, Hamish R. C. Smith, Wayne M. Yokoyama, and Anthony A. Scalzo

Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells
PNAS 2003 100: 13483-13488; published online before print November 3 2003, 10.1073/pnas.2233572100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Götz R. A. Ehrhardt, Randall S. Davis, Joyce T. Hsu, Chuen-Miin Leu, Annette Ehrhardt, and Max D. Cooper

The inhibitory potential of Fc receptor homolog 4 on memory B cells
PNAS 2003 100: 13489-13494; published online before print November 3 2003, 10.1073/pnas.1935944100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Medical Sciences

Shunichi Fukuda and Geert W. Schmid-Schönbein

Regulation of CD18 expression on neutrophils in response to fluid shear stress
PNAS 2003 100: 13152-13157; published online before print October 31 2003, 10.1073/pnas.2336130100 [Abstract] [Full Text] [PDF]  

Huawei Li, Graham Roblin, Hong Liu, and Stefan Heller From The Cover: Generation of hair cells by stepwise differentiation of embryonic stem cells PNAS 2003 100: 13495-13500; published online before print October 30 2003, 10.1073/pnas.2334503100 [Abstract] [Full Text] [PDF]

Nitza G. Shoham, Michael Centola, Elizabeth Mansfield, Keith M. Hull, Geryl Wood, Carol A. Wise, and Daniel L. Kastner

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway
PNAS 2003 100: 13501-13506; published online before print October 31 2003, 10.1073/pnas.2135380100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Maty Tzukerman, Tzur Rosenberg, Yael Ravel, Irena Reiter, Raymond Coleman, and Karl Skorecki

An experimental platform for studying growth and invasiveness of tumor cells within teratomas derived from human embryonic stem cells
PNAS 2003 100: 13507-13512; published online before print October 22 2003, 10.1073/pnas.2235551100 [Abstract] [Full Text] [PDF]  

Joshua B. Rubin, Andrew L. Kung, Robyn S. Klein, Jennifer A. Chan, YanPing Sun, Karl Schmidt, Mark W. Kieran, Andrew D. Luster, and Rosalind A. Segal

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
PNAS 2003 100: 13513-13518; published online before print October 31 2003, 10.1073/pnas.2235846100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Wiebke Wolfsgruber, Susanne Feil, Sabine Brummer, Oliver Kuppinger, Franz Hofmann, and Robert Feil

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells
PNAS 2003 100: 13519-13524; published online before print November 3 2003, 10.1073/pnas.1936024100 [Abstract] [Full Text] [PDF]  

Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Françoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, and Guilan Vodjdani

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
PNAS 2003 100: 13525-13530; published online before print November 3 2003, 10.1073/pnas.2233056100 [Abstract] [Full Text] [PDF]  

James X. Rong, Mark Shapiro, Eugene Trogan, and Edward A. Fisher

Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading
PNAS 2003 100: 13531-13536; published online before print October 27 2003, 10.1073/pnas.1735526100 [Abstract] [Full Text] [PDF]  

Guoan Chen, Tarek G Gharib, Hong Wang, Chiang-Ching Huang, Rork Kuick, Dafydd G. Thomas, Kerby A. Shedden, David E. Misek, Jeremy M. G. Taylor, Thomas J. Giordano, Sharon L. R. Kardia, Mark D. Iannettoni, John Yee, Philip J. Hogg, Mark B. Orringer, Samir M. Hanash, and David G. Beer

Protein profiles associated with survival in lung adenocarcinoma
PNAS 2003 100: 13537-13542; published online before print October 22 2003, 10.1073/pnas.2233850100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sylvia Fong, Yoko Itahana, Tomoki Sumida, Jarnail Singh, Jean-Philippe Coppe, Yong Liu, Peter C. Richards, James L. Bennington, Nancy M. Lee, Robert J. Debs, and Pierre-Yves Desprez

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
PNAS 2003 100: 13543-13548; published online before print October 24 2003, 10.1073/pnas.2230238100 [Abstract] [Full Text] [PDF]  

L. R. Hirsch, R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, and J. L. West

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
PNAS 2003 100: 13549-13554; published online before print November 3 2003, 10.1073/pnas.2232479100 [Abstract] [Full Text] [PDF]  

F. Li, R. Goila-Gaur, K. Salzwedel, N. R. Kilgore, M. Reddick, C. Matallana, A. Castillo, D. Zoumplis, D. E. Martin, J. M. Orenstein, G. P. Allaway, E. O. Freed, and C. T. Wild

PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing
PNAS 2003 100: 13555-13560; published online before print October 22 2003, 10.1073/pnas.2234683100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Indranil Dey, Kathy Keller, Adam Belley, and Kris Chadee

Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica
PNAS 2003 100: 13561-13566; published online before print October 29 2003, 10.1073/pnas.1835863100 [Abstract] [Full Text] [PDF]  

Tsuyoshi Akagi, Ken Sasai, and Hidesaburo Hanafusa

Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation
PNAS 2003 100: 13567-13572; published online before print November 3 2003, 10.1073/pnas.1834876100 [Abstract] [Full Text] [PDF]  

Sofia Movérare, Katrien Venken, Anna-Lena Eriksson, Niklas Andersson, Stanko Skrtic, Jon Wergedal, Subburaman Mohan, Phil Salmon, Roger Bouillon, Jan-Åke Gustafsson, Dirk Vanderschueren, and Claes Ohlsson

Differential effects on bone of estrogen receptor and androgen receptor activation in orchidectomized adult male mice
PNAS 2003 100: 13573-13578; published online before print October 22 2003, 10.1073/pnas.2233084100 [Abstract] [Full Text] [PDF]  

Microbiology

Rahul A. Aras, Josephine Kang, Ariane I. Tschumi, Yasuaki Harasaki, and Martin J. Blaser

Extensive repetitive DNA facilitates prokaryotic genome plasticity
PNAS 2003 100: 13579-13584; published online before print October 30 2003, 10.1073/pnas.1735481100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Eain Murphy, Isidore Rigoutsos, Tetsuo Shibuya, and Thomas E. Shenk

Reevaluation of human cytomegalovirus coding potential
PNAS 2003 100: 13585-13590; published online before print October 30 2003, 10.1073/pnas.1735466100 [Abstract] [Full Text] [PDF]  

C. O. Jeon, W. Park, P. Padmanabhan, C. DeRito, J. R. Snape, and E. L. Madsen

Discovery of a bacterium, with distinctive dioxygenase, that is responsible for in situ biodegradation in contaminated sediment
PNAS 2003 100: 13591-13596; published online before print November 3 2003, 10.1073/pnas.1735529100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Alejandro Correa, Zachary A. Lewis, Andrew V. Greene, Irene J. March, Richard H. Gomer, and Deborah Bell-Pedersen

Multiple oscillators regulate circadian gene expression in Neurospora
PNAS 2003 100: 13597-13602; published online before print November 3 2003, 10.1073/pnas.2233734100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shunji Nakano, Elke Küster-Schöck, Alan D. Grossman, and Peter Zuber

Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis
PNAS 2003 100: 13603-13608; published online before print November 3 2003, 10.1073/pnas.2235180100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Neuroscience

C. Sue Furman, Daniel A. Gorelick-Feldman, Kimberly G. V. Davidson, Thomas Yasumura, John D. Neely, Peter Agre, and John E. Rash

Aquaporin-4 square array assembly: Opposing actions of M1 and M23 isoforms
PNAS 2003 100: 13609-13614; published online before print November 3 2003, 10.1073/pnas.2235843100 [Abstract] [Full Text] [PDF]  

Mahmood Amiry-Moghaddam, Anne Williamson, Maria Palomba, Tore Eid, Nihal C. de Lanerolle, Erlend A. Nagelhus, Marvin E. Adams, Stanley C. Froehner, Peter Agre, and Ole P. Ottersen

Delayed K⁺ clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of -syntrophin-null mice
PNAS 2003 100: 13615-13620; published online before print November 3 2003, 10.1073/pnas.2336064100 [Abstract] [Full Text] [PDF]  

W. Liu, Vedrana Montana, Edwin R. Chapman, U. Mohideen, and Vladimir Parpura

Botulinum toxin type B micromechanosensor
PNAS 2003 100: 13621-13625; published online before print October 22 2003, 10.1073/pnas.2233819100 [Abstract] [Full Text] [PDF]  

B. A. Strange, R. Hurlemann, and R. J. Dolan From The Cover: An emotion-induced retrograde amnesia in humans is amygdala- and -adrenergic-dependent PNAS 2003 100: 13626-13631; published online before print October 31 2003, 10.1073/pnas.1635116100 [Abstract] [Full Text] [PDF] [Supporting Text]   See Commentary on page 13123

Christine T. Ekdahl, Jan-Hendrik Claasen, Sara Bonde, Zaal Kokaia, and Olle Lindvall

Inflammation is detrimental for neurogenesis in adult brain
PNAS 2003 100: 13632-13637; published online before print October 27 2003, 10.1073/pnas.2234031100 [Abstract] [Full Text] [PDF]  

Carl C. H. Petersen, Thomas T. G. Hahn, Mayank Mehta, Amiram Grinvald, and Bert Sakmann

Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
PNAS 2003 100: 13638-13643; published online before print October 31 2003, 10.1073/pnas.2235811100 [Abstract] [Full Text] [PDF]  

Roberto Bruzzone, Sheriar G. Hormuzdi, Michael T. Barbe, Anne Herb, and Hannah Monyer

Pannexins, a family of gap junction proteins expressed in brain
PNAS 2003 100: 13644-13649; published online before print November 3 2003, 10.1073/pnas.2233464100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Patrice D. Smith, Stephen J. Crocker, Vernice Jackson-Lewis, Kelly L. Jordan-Sciutto, Shawn Hayley, Matthew P. Mount, Michael J. O'Hare, Steven Callaghan, Ruth S. Slack, Serge Przedborski, Hymie Anisman, and David S. Park

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
PNAS 2003 100: 13650-13655; published online before print October 31 2003, 10.1073/pnas.2232515100 [Abstract] [Full Text] [PDF]  

Venetia Zachariou, Dan Georgescu, Nick Sanchez, Zia Rahman, Ralph DiLeone, Olivier Berton, Rachael L. Neve, Laura J. Sim-Selley, Dana E. Selley, Stephen J. Gold, and Eric J. Nestler

Essential role for RGS9 in opiate action
PNAS 2003 100: 13656-13661; published online before print October 31 2003, 10.1073/pnas.2232594100 [Abstract] [Full Text] [PDF]  

Jie Fan, Baerbel Rohrer, Gennadiy Moiseyev, Jian-xing Ma, and Rosalie K. Crouch

Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice <