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COMMENTARIES

Richard B. Gaynor

A role for extracellular matrix binding receptors in regulating hematopoietic growth factor signaling
PNAS 2003 100: 13737-13738; published online before print November 17 2003, 10.1073/pnas.2536856100 [Extract] [Full Text] [PDF]  
See companion article on page 14000

Darrell J. Irvine

Function-specific variations in the immunological synapses formed by cytotoxic T cells
PNAS 2003 100: 13739-13740; published online before print November 17 2003, 10.1073/pnas.2536626100 [Extract] [Full Text] [PDF]  
See companion article on page 14145

PHYSICAL SCIENCES

Applied Physical Sciences

Paul R. Garabedian

Computational mathematics and physics of fusion reactors
PNAS 2003 100: 13741-13745; published online before print November 12 2003, 10.1073/pnas.2436390100 [Abstract] [Full Text] [PDF]  

Chemistry

Samir Kumar Pal, Liang Zhao, Tianbing Xia, and Ahmed H. Zewail

Site- and sequence-selective ultrafast hydration of DNA
PNAS 2003 100: 13746-13751; published online before print November 5 2003, 10.1073/pnas.2336222100 [Abstract] [Full Text] [PDF]  

Joseph R. Roscioli and David W. Pratt

Base pair analogs in the gas phase
PNAS 2003 100: 13752-13754; published online before print November 11 2003, 10.1073/pnas.2333806100 [Abstract] [Full Text] [PDF]  

Engineering

SOCIAL SCIENCES

Psychology

Hugh R. Wilson

Computational evidence for a rivalry hierarchy in vision
PNAS 2003 100: 14499-14503; published online before print November 11 2003, 10.1073/pnas.2333622100 [Abstract] [Full Text] [PDF]  

Cindy Lustig, Abraham Z. Snyder, Mehul Bhakta, Katherine C. O'Brien, Mark McAvoy, Marcus E. Raichle, John C. Morris, and Randy L. Buckner

Functional deactivations: Change with age and dementia of the Alzheimer type
PNAS 2003 100: 14504-14509; published online before print November 7 2003, 10.1073/pnas.2235925100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

David J. Brenner, Richard Doll, Dudley T. Goodhead, Eric J. Hall, Charles E. Land, John B. Little, Jay H. Lubin, Dale L. Preston, R. Julian Preston, Jerome S. Puskin, Elaine Ron, Rainer K. Sachs, Jonathan M. Samet, Richard B. Setlow, and Marco Zaider

Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
PNAS 2003 100: 13761-13766; published online before print November 10 2003, 10.1073/pnas.2235592100 [Abstract] [Full Text] [PDF]  

Biochemistry

Michael H. Woo, Carmen Losasso, Hong Guo, Luca Pattarello, Piero Benedetti, and Mary-Ann Bjornsti

Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality
PNAS 2003 100: 13767-13772; published online before print October 29 2003, 10.1073/pnas.2235886100 [Abstract] [Full Text] [PDF]  

Anna Petryk, James T. Warren, Guillermo Marqués, Michael P. Jarcho, Lawrence I. Gilbert, Jonathan Kahler, Jean-Philippe Parvy, Yutai Li, Chantal Dauphin-Villemant, and Michael B. O'Connor

Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone
PNAS 2003 100: 13773-13778; published online before print November 10 2003, 10.1073/pnas.2336088100 [Abstract] [Full Text] [PDF]  

James Regeimbal, Stefan Gleiter, Bernard L. Trumpower, Chang-An Yu, Mithun Diwakar, David P. Ballou, and James C. A. Bardwell

Disulfide bond formation involves a quinhydrone-type charge–transfer complex
PNAS 2003 100: 13779-13784; published online before print November 11 2003, 10.1073/pnas.1935988100 [Abstract] [Full Text] [PDF]  

Swati Prasad, Kelly J. Wright, Dolly Banerjee Roy, Leslie A. Bush, Angelene M. Cantwell, and Enrico Di Cera

Redesigning the monovalent cation specificity of an enzyme
PNAS 2003 100: 13785-13790; published online before print November 11 2003, 10.1073/pnas.2333109100 [Abstract] [Full Text] [PDF]  

Paola Fortugno, Elena Beltrami, Janet Plescia, Jason Fontana, Deepti Pradhan, Pier Carlo Marchisio, William C. Sessa, and Dario C. Altieri

Regulation of survivin function by Hsp90
PNAS 2003 100: 13791-13796; published online before print November 12 2003, 10.1073/pnas.2434345100 [Abstract] [Full Text] [PDF]  

Oded Danziger, Dalia Rivenzon-Segal, Sharon G. Wolf, and Amnon Horovitz

Conversion of the allosteric transition of GroEL from concerted to sequential by the single mutation Asp-155 Ala
PNAS 2003 100: 13797-13802; published online before print November 13 2003, 10.1073/pnas.2333925100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Michael Mourez, Ming Yan, D. Borden Lacy, Lisa Dillon, Lori Bentsen, Amy Marpoe, Clémence Maurin, Eileen Hotze, Darran Wigelsworth, Ruth-Anne Pimental, Jimmy D. Ballard, R. John Collier, and Rodney K. Tweten

Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis
PNAS 2003 100: 13803-13808; published online before print November 17 2003, 10.1073/pnas.2436299100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Ana L. Carvalho, Fernando M. V. Dias, José A. M. Prates, Tibor Nagy, Harry J. Gilbert, Gideon J. Davies, Luís M. A. Ferreira, Maria J. Romão, and Carlos M. G. A. Fontes

Cellulosome assembly revealed by the crystal structure of the cohesin–dockerin complex
PNAS 2003 100: 13809-13814; published online before print November 17 2003, 10.1073/pnas.1936124100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Sandra L. Martin, Dan Branciforte, David Keller, and David L. Bain

Trimeric structure for an essential protein in L1 retrotransposition
PNAS 2003 100: 13815-13820; published online before print November 13 2003, 10.1073/pnas.2336221100 [Abstract] [Full Text] [PDF]  

Karin Fritz-Wolf, Andreas Becker, Stefan Rahlfs, Petra Harwaldt, R. Heiner Schirmer, Wolfgang Kabsch, and Katja Becker

X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum
PNAS 2003 100: 13821-13826; published online before print November 17 2003, 10.1073/pnas.2333763100 [Abstract] [Full Text] [PDF]  

Lee Zou, Dou Liu, and Stephen J. Elledge

Replication protein A-mediated recruitment and activation of Rad17 complexes
PNAS 2003 100: 13827-13832; published online before print November 6 2003, 10.1073/pnas.2336100100 [Abstract] [Full Text] [PDF]  

Anders Sundqvist and Johan Ericsson

Transcription-dependent degradation controls the stability of the SREBP family of transcription factors
PNAS 2003 100: 13833-13838; published online before print November 13 2003, 10.1073/pnas.2335135100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Patrick D. D'Silva, Brenda Schilke, William Walter, Amy Andrew, and Elizabeth A. Craig

J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix
PNAS 2003 100: 13839-13844; published online before print November 6 2003, 10.1073/pnas.1936150100 [Abstract] [Full Text] [PDF]  

Inez Rogatsky, Jen-Chywan Wang, Mika K. Derynck, Daisuke F. Nonaka, Daniel B. Khodabakhsh, Christopher M. Haqq, Beatrice D. Darimont, Michael J. Garabedian, and Keith R. Yamamoto

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor
PNAS 2003 100: 13845-13850; published online before print November 14 2003, 10.1073/pnas.2336092100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Junichi Tanaka, Yuling Yan, Jeongeun Choi, Jihong Bai, Vadim A. Klenchin, Ivan Rayment, and Gerard Marriott

Biomolecular mimicry in the actin cytoskeleton: Mechanisms underlying the cytotoxicity of kabiramide C and related macrolides
PNAS 2003 100: 13851-13856; published online before print November 11 2003, 10.1073/pnas.2233339100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Rhonda Perriman, Imre Barta, Gia K. Voeltz, John Abelson, and Manuel Ares, Jr.

ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA
PNAS 2003 100: 13857-13862; published online before print November 10 2003, 10.1073/pnas.2036312100 [Abstract] [Full Text] [PDF]  

Juan C. Salazar, Ivan Ahel, Omar Orellana, Debra Tumbula-Hansen, Robert Krieger, Lacy Daniels, and Dieter Söll

Coevolution of an aminoacyl-tRNA synthetase with its tRNA substrates
PNAS 2003 100: 13863-13868; published online before print November 13 2003, 10.1073/pnas.1936123100 [Abstract] [Full Text] [PDF]  

Manas K. Chattopadhyay, Celia White Tabor, and Herbert Tabor

Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: Spermine is converted to spermidine in vivo by the FMS1-amine oxidase
PNAS 2003 100: 13869-13874; published online before print November 14 2003, 10.1073/pnas.1835918100 [Abstract] [Full Text] [PDF]  

Steen V. Petersen, Tim D. Oury, Zuzana Valnickova, Ida B. Thøgersen, Peter Højrup, James D. Crapo, and Jan J. Enghild

The dual nature of human extracellular superoxide dismutase: One sequence and two structures
PNAS 2003 100: 13875-13880; published online before print November 13 2003, 10.1073/pnas.2436143100 [Abstract] [Full Text] [PDF]  

Richa Rawat, Adrian Whitty, and Peter J. Tonge

The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance
PNAS 2003 100: 13881-13886; published online before print November 17 2003, 10.1073/pnas.2235848100 [Abstract] [Full Text] [PDF]  

Laurent Kuras, Tilman Borggrefe, and Roger D. Kornberg

Association of the Mediator complex with enhancers of active genes
PNAS 2003 100: 13887-13891; published online before print November 17 2003, 10.1073/pnas.2036346100 [Abstract] [Full Text] [PDF]  

Christophe Cans, Brent J. Passer, Vyacheslav Shalak, Vanessa Nancy-Portebois, Virginie Crible, Nathalie Amzallag, David Allanic, Rowena Tufino, Manuela Argentini, Dino Moras, Giusy Fiucci, Bruno Goud, Marc Mirande, Robert Amson, and Adam Telerman

Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A
PNAS 2003 100: 13892-13897; published online before print November 17 2003, 10.1073/pnas.2335950100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

Samir Kumar Pal, Liang Zhao, Tianbing Xia, and Ahmed H. Zewail

Site- and sequence-selective ultrafast hydration of DNA
PNAS 2003 100: 13746-13751; published online before print November 5 2003, 10.1073/pnas.2336222100 [Abstract] [Full Text] [PDF]  

Angel E. García and José N. Onuchic

Folding a protein in a computer: An atomic description of the folding/unfolding of protein A
PNAS 2003 100: 13898-13903; published online before print November 17 2003, 10.1073/pnas.2335541100 [Abstract] [Full Text] [PDF]  

Laura J. W. Murray, W. Bryan Arendall, III, David C. Richardson, and Jane S. Richardson

RNA backbone is rotameric
PNAS 2003 100: 13904-13909; published online before print November 11 2003, 10.1073/pnas.1835769100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Sungsu Park, Peter M. Wolanin, Emil A. Yuzbashyan, Hai Lin, Nicholas C. Darnton, Jeffry B. Stock, Pascal Silberzan, and Robert Austin From the Cover: Influence of topology on bacterial social interaction PNAS 2003 100: 13910-13915; published online before print November 17 2003, 10.1073/pnas.1935975100 [Abstract] [Full Text] [PDF]

Y. Zenmei Ohkubo and Charles L. Brooks, III

Exploring Flory's isolated-pair hypothesis: Statistical mechanics of helix–coil transitions in polyalanine and the C-peptide from RNase A
PNAS 2003 100: 13916-13921; published online before print November 13 2003, 10.1073/pnas.2334257100 [Abstract] [Full Text] [PDF]  

Michael F. Hagan, Aaron R. Dinner, David Chandler, and Arup K. Chakraborty

Atomistic understanding of kinetic pathways for single base-pair binding and unbinding in DNA
PNAS 2003 100: 13922-13927; published online before print November 14 2003, 10.1073/pnas.2036378100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Martin G. Burke, Rüdiger Woscholski, and S. N. Yaliraki

Differential hydrophobicity drives self-assembly in Huntington's disease
PNAS 2003 100: 13928-13933; published online before print November 14 2003, 10.1073/pnas.1936025100 [Abstract] [Full Text] [PDF]  

Hugh Nymeyer and Angel E. García

Simulation of the folding equilibrium of -helical peptides: A comparison of the generalized Born approximation with explicit solvent
PNAS 2003 100: 13934-13939; published online before print November 14 2003, 10.1073/pnas.2232868100 [Abstract] [Full Text] [PDF]  

Georg Nagel, Tanjef Szellas, Wolfram Huhn, Suneel Kateriya, Nona Adeishvili, Peter Berthold, Doris Ollig, Peter Hegemann, and Ernst Bamberg

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
PNAS 2003 100: 13940-13945; published online before print November 13 2003, 10.1073/pnas.1936192100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Isabella L. Karle, Hosahudya N. Gopi, and Padmanabhan Balaram

Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located D amino acids
PNAS 2003 100: 13946-13951; published online before print November 14 2003, 10.1073/pnas.2336106100 [Abstract] [Full Text] [PDF]  

Katsuhiko Sato, Yoichiro Ito, Tetsuya Yomo, and Kunihiko Kaneko

On the relation between fluctuation and response in biological systems
PNAS 2003 100: 14086-14090; published online before print November 13 2003, 10.1073/pnas.2334996100 [Abstract] [Full Text] [PDF]  

Cell Biology

Daniela U. Spahl, Denise Berendji-Grün, Christoph V. Suschek, Victoria Kolb-Bachofen, and Klaus-D. Kröncke

Regulation of zinc homeostasis by inducible NO synthase-derived NO: Nuclear metallothionein translocation and intranuclear Zn²⁺ release
PNAS 2003 100: 13952-13957; published online before print November 14 2003, 10.1073/pnas.2335190100 [Abstract] [Full Text] [PDF]  

Inna A. Belyantseva, Erich T. Boger, and Thomas B. Friedman

Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle
PNAS 2003 100: 13958-13963; published online before print November 10 2003, 10.1073/pnas.2334417100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jeanne Kwik, Sarah Boyle, David Fooksman, Leonid Margolis, Michael P. Sheetz, and Michael Edidin

Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin
PNAS 2003 100: 13964-13969; published online before print November 11 2003, 10.1073/pnas.2336102100 [Abstract] [Full Text] [PDF]  

Sonya W. Song, Gregory N. Fuller, Asadullah Khan, Shouming Kong, Weiping Shen, Ellen Taylor, Latha Ramdas, Frederick F. Lang, and Wei Zhang

IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion
PNAS 2003 100: 13970-13975; published online before print November 14 2003, 10.1073/pnas.2332186100 [Abstract] [Full Text] [PDF]  

L. Tirián, E. Hlavanda, J. Oláh, I. Horváth, F. Orosz, B. Szabó, J. Kovács, J. Szabad, and J. Ovádi

TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation
PNAS 2003 100: 13976-13981; published online before print November 17 2003, 10.1073/pnas.2436331100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Candace L. Steeves, Mary-Anne Hammer, Glenn B. Walker, Duncan Rae, Nicolas A. Stewart, and Jay M. Baltz

The glycine neurotransmitter transporter GLYT1 is an organic osmolyte transporter regulating cell volume in cleavage-stage embryos
PNAS 2003 100: 13982-13987; published online before print November 13 2003, 10.1073/pnas.2334537100 [Abstract] [Full Text] [PDF]  

Joseph E. De Larco, Beverly R. K. Wuertz, Douglas Yee, Brenda L. Rickert, and Leo T. Furcht

Atypical methylation of the interleukin-8 gene correlates strongly with the metastatic potential of breast carcinoma cells
PNAS 2003 100: 13988-13993; published online before print November 17 2003, 10.1073/pnas.2335921100 [Abstract] [Full Text] [PDF]  

Kathryn R. Coser, Jessica Chesnes, Jingyung Hur, Sandip Ray, Kurt J. Isselbacher, and Toshi Shioda

Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray
PNAS 2003 100: 13994-13999; published online before print November 10 2003, 10.1073/pnas.2235866100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Jian Chen, Juan M. Cárcamo, Oriana Bórquez-Ojeda, Hediye Erdjument-Bromage, Paul Tempst, and David W. Golde From the Cover: The laminin receptor modulates granulocyte–macrophage colony-stimulating factor receptor complex formation and modulates its signaling PNAS 2003 100: 14000-14005; published online before print November 12 2003, 10.1073/pnas.2334584100 [Abstract] [Full Text] [PDF]   See Commentary on page 13737

Mei A. Lim, Chintan K. Kikani, Michael J. Wick, and Lily Q. Dong

Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): A potential regulatory mechanism for PDK-1 function
PNAS 2003 100: 14006-14011; published online before print November 17 2003, 10.1073/pnas.2335486100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yanru Chen, Xuemei Guo, Fang-Ming Deng, Feng-Xia Liang, Wenyu Sun, Mindong Ren, Tetsuro Izumi, David D. Sabatini, Tung-Tien Sun, and Gert Kreibich

Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes
PNAS 2003 100: 14012-14017; published online before print November 18 2003, 10.1073/pnas.2436350100 [Abstract] [Full Text] [PDF]  

Christopher L. Sansam, K. Sam Wells, and Ronald B. Emeson

Modulation of RNA editing by functional nucleolar sequestration of ADAR2
PNAS 2003 100: 14018-14023; published online before print November 11 2003, 10.1073/pnas.2336131100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Kornelia Schlombs, Thomas Wagner, and Jochen Scheel

Site-1 protease is required for cartilage development in zebrafish
PNAS 2003 100: 14024-14029; published online before print November 11 2003, 10.1073/pnas.2331794100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Samuel G. Katz, Aimee Williams, Jifu Yang, Yuko Fujiwara, Alice P. Tsang, Jonathan A. Epstein, and Stuart H. Orkin

Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development
PNAS 2003 100: 14030-14035; published online before print November 12 2003, 10.1073/pnas.1936250100 [Abstract] [Full Text] [PDF]  

Valérie Dupé, Nicolas Matt, Jean-Marie Garnier, Pierre Chambon, Manuel Mark, and Norbert B. Ghyselinck

A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment
PNAS 2003 100: 14036-14041; published online before print November 17 2003, 10.1073/pnas.2336223100 [Abstract] [Full Text] [PDF]  

Yuzo Niki and Anthony P. Mahowald

Ovarian cystocytes can repopulate the embryonic germ line and produce functional gametes
PNAS 2003 100: 14042-14045; published online before print November 10 2003, 10.1073/pnas.2235591100 [Abstract] [Full Text] [PDF]  

C. González-Estévez, T. Momose, W. J. Gehring, and E. Saló

Transgenic planarian lines obtained by electroporation using transposon-derived vectors and an eye-specific GFP marker
PNAS 2003 100: 14046-14051; published online before print November 13 2003, 10.1073/pnas.2335980100 [Abstract] [Full Text] [PDF]  

Ecology

Norbert J. Cordeiro and Henry F. Howe

Forest fragmentation severs mutualism between seed dispersers and an endemic African tree
PNAS 2003 100: 14052-14056; published online before print November 12 2003, 10.1073/pnas.2331023100 [Abstract] [Full Text] [PDF]  

J. R. Speakman, T. Ergon, R. Cavanagh, K. Reid, D. M. Scantlebury, and X. Lambin

Resting and daily energy expenditures of free-living field voles are positively correlated but reflect extrinsic rather than intrinsic effects
PNAS 2003 100: 14057-14062; published online before print November 13 2003, 10.1073/pnas.2235671100 [Abstract] [Full Text] [PDF]  

Karen Oberhauser and A. Townsend Peterson

Modeling current and future potential wintering distributions of eastern North American monarch butterflies
PNAS 2003 100: 14063-14068; published online before print November 11 2003, 10.1073/pnas.2331584100 [Abstract] [Full Text] [PDF]  

Gonçalo Ferraz, Gareth J. Russell, Philip C. Stouffer, Richard O. Bierregaard, Jr., Stuart L. Pimm, and Thomas E. Lovejoy

Rates of species loss from Amazonian forest fragments
PNAS 2003 100: 14069-14073; published online before print November 12 2003, 10.1073/pnas.2336195100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Evolution

Charlotte J. Allender, Ole Seehausen, Mairi E. Knight, George F. Turner, and Norman Maclean

Divergent selection during speciation of Lake Malawi cichlid fishes inferred from parallel radiations in nuptial coloration
PNAS 2003 100: 14074-14079; published online before print November 12 2003, 10.1073/pnas.2332665100 [Abstract] [Full Text] [PDF] [Supporting Information]  

J. Kozlowski, M. Konarzewski, and A. T. Gawelczyk

Cell size as a link between noncoding DNA and metabolic rate scaling
PNAS 2003 100: 14080-14085; published online before print November 13 2003, 10.1073/pnas.2334605100 [Abstract] [Full Text] [PDF]  

Katsuhiko Sato, Yoichiro Ito, Tetsuya Yomo, and Kunihiko Kaneko

On the relation between fluctuation and response in biological systems
PNAS 2003 100: 14086-14090; published online before print November 13 2003, 10.1073/pnas.2334996100 [Abstract] [Full Text] [PDF]  

Genetics

Elena Casacuberta and Mary-Lou Pardue

HeT-A elements in Drosophila virilis: Retrotransposon telomeres are conserved across the Drosophila genus
PNAS 2003 100: 14091-14096; published online before print November 12 2003, 10.1073/pnas.1936193100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Tomas Stopka and Arthur I. Skoultchi

The ISWI ATPase Snf2h is required for early mouse development
PNAS 2003 100: 14097-14102; published online before print November 14 2003, 10.1073/pnas.2336105100 [Abstract] [Full Text] [PDF]  

Aubrey C. Frank, Kimberly A. Meyers, Ian C. Welsh, and Timothy P. O'Brien

Development of an enhanced GFP-based dual-color reporter to facilitate genetic screens for the recovery of mutations in mice
PNAS 2003 100: 14103-14108; published online before print November 13 2003, 10.1073/pnas.1936166100 [Abstract] [Full Text] [PDF]  

Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, and Arthur T. Sands

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention
PNAS 2003 100: 14109-14114; published online before print November 10 2003, 10.1073/pnas.2336103100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Bard J. Geesaman, Erica Benson, Stephanie J. Brewster, Louis M. Kunkel, Hélène Blanché, Gilles Thomas, Thomas T. Perls, Mark J. Daly, and Annibale A. Puca

Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan
PNAS 2003 100: 14115-14120; published online before print November 13 2003, 10.1073/pnas.1936249100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kazuei Mita, Mitsuoki Morimyo, Kazuhiro Okano, Yoshiko Koike, Junko Nohata, Hideki Kawasaki, Keiko Kadono-Okuda, Kimiko Yamamoto, Masataka G. Suzuki, Toru Shimada, Marian R. Goldsmith, and Susumu Maeda

The construction of an EST database for Bombyx mori and its application
PNAS 2003 100: 14121-14126; published online before print November 12 2003, 10.1073/pnas.2234984100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Jianxuan Zhang, Ning Zheng, and Pengbo Zhou

Exploring the functional complexity of cellular proteins by protein knockout
PNAS 2003 100: 14127-14132; published online before print October 30 2003, 10.1073/pnas.2233012100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biao He, Liang You, Kazutsugu Uematsu, Keling Zang, Zhidong Xu, Amie Y. Lee, Joseph F. Costello, Frank McCormick, and David M. Jablons

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
PNAS 2003 100: 14133-14138; published online before print November 14 2003, 10.1073/pnas.2232790100 [Abstract] [Full Text] [PDF]  

Immunology

Sanjeev Kumar, George K. Christophides, Rafael Cantera, Bradley Charles, Yeon Soo Han, Stephan Meister, George Dimopoulos, Fotis C. Kafatos, and Carolina Barillas-Mury

The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae
PNAS 2003 100: 14139-14144; published online before print November 17 2003, 10.1073/pnas.2036262100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Mustapha Faroudi, Clemens Utzny, Mariolina Salio, Vincenzo Cerundolo, Martine Guiraud, Sabina Müller, and Salvatore Valitutti From the Cover: Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold PNAS 2003 100: 14145-14150; published online before print November 10 2003, 10.1073/pnas.2334336100 [Abstract] [Full Text] [PDF] [Supporting Movies]   See Commentary on page 13739

Jordan S. Orange, K. Eliza Harris, Milena M. Andzelm, Markus M. Valter, Raif S. Geha, and Jack L. Strominger

The mature activating natural killer cell immunologic synapse is formed in distinct stages
PNAS 2003 100: 14151-14156; published online before print November 11 2003, 10.1073/pnas.1835830100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Rina Aharoni, Basak Kayhan, Raya Eilam, Michael Sela, and Ruth Arnon

Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ
PNAS 2003 100: 14157-14162; published online before print November 12 2003, 10.1073/pnas.2336171100 [Abstract] [Full Text] [PDF]  

Roza I. Nurieva, Xoi Moui Mai, Katherine Forbush, Michael J. Bevan, and Chen Dong

B7h is required for T cell activation, differentiation, and effector function
PNAS 2003 100: 14163-14168; published online before print November 13 2003, 10.1073/pnas.2335041100 [Abstract] [Full Text] [PDF]  

Sigrid Dubois, Weinian Shou, Laura S. Haneline, Sidney Fleischer, Thomas A. Waldmann, and Jürgen R. Müller

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells
PNAS 2003 100: 14169-14174; published online before print November 6 2003, 10.1073/pnas.2335979100 [Abstract] [Full Text] [PDF]  

Marc Pellegrini, Gabrielle Belz, Philippe Bouillet, and Andreas Strasser

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
PNAS 2003 100: 14175-14180; published online before print November 17 2003, 10.1073/pnas.2336198100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Paola Bossù, Detlef Neumann, Elda Del Giudice, Antonio Ciaramella, Isabelle Gloaguen, Giamila Fantuzzi, Charles A. Dinarello, Emma Di Carlo, Piero Musiani, Pier Luigi Meroni, Gianfranco Caselli, Paolo Ruggiero, and Diana Boraschi

IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease
PNAS 2003 100: 14181-14186; published online before print November 13 2003, 10.1073/pnas.2336094100 [Abstract] [Full Text] [PDF]  

Medical Sciences

Thomas A. Bayer, Stephanie Schäfer, Andreas Simons, André Kemmling, Thomas Kamer, Ralf Tepest, Anne Eckert, Katrin Schüssel, Oliver Eikenberg, Christine Sturchler-Pierrat, Dorothee Abramowski, Matthias Staufenbiel, and Gerd Multhaup

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid A production in APP23 transgenic mice
PNAS 2003 100: 14187-14192; published online before print November 14 2003, 10.1073/pnas.2332818100 [Abstract] [Full Text] [PDF]  

Amie L. Phinney, Bettina Drisaldi, Stephen D. Schmidt, Stan Lugowski, Veronica Coronado, Yan Liang, Patrick Horne, Jing Yang, Joannis Sekoulidis, Janaky Coomaraswamy, M. Azhar Chishti, Diane W. Cox, Paul M. Mathews, Ralph A. Nixon, George A. Carlson, Peter St George-Hyslop, and David Westaway

In vivo reduction of amyloid- by a mutant copper transporter
PNAS 2003 100: 14193-14198; published online before print November 14 2003, 10.1073/pnas.2332851100 [Abstract] [Full Text] [PDF]  

Birke Bartosch, Jens Bukh, Jean-Christophe Meunier, Christelle Granier, Ronald E. Engle, William C. Blackwelder, Suzanne U. Emerson, François-Loïc Cosset, and Robert H. Purcell

In vitro assay for neutralizing antibody to hepatitis C virus: Evidence for broadly conserved neutralization epitopes
PNAS 2003 100: 14199-14204; published online before print November 14 2003, 10.1073/pnas.2335981100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Suzanne J. Bakewell, Patrick Nestor, Srinivasa Prasad, Michael H. Tomasson, Nikki Dowland, Mukund Mehrotra, Robert Scarborough, James Kanter, Keith Abe, David Phillips, and Katherine N. Weilbaecher

Platelet and osteoclast ₃ integrins are critical for bone metastasis
PNAS 2003 100: 14205-14210; published online before print November 11 2003, 10.1073/pnas.2234372100 [Abstract] [Full Text] [PDF]  

M. Ehrhart-Bornstein, V. Lamounier-Zepter, A. Schraven, J. Langenbach, H. S. Willenberg, A. Barthel, H. Hauner, S. M. McCann, W. A. Scherbaum, and S. R. Bornstein

Human adipocytes secrete mineralocorticoid-releasing factors
PNAS 2003 100: 14211-14216; published online before print November 12 2003, 10.1073/pnas.2336140100 [Abstract] [Full Text] [PDF]  

Stanislav Shklyaev, George Aslanidi, Michael Tennant, Victor Prima, Eric Kohlbrenner, Vadim Kroutov, Martha Campbell-Thompson, James Crawford, Eugene W. Shek, Philip J. Scarpace, and Sergei Zolotukhin

Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
PNAS 2003 100: 14217-14222; published online before print November 14 2003, 10.1073/pnas.2333912100 [Abstract] [Full Text] [PDF]  

Walter Dunn, Cassie Chou, Hong Li, Rong Hai, David Patterson, Viktor Stolc, Hua Zhu, and Fenyong Liu

Functional profiling of a human cytomegalovirus genome
PNAS 2003 100: 14223-14228; published online before print November 17 2003, 10.1073/pnas.2334032100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Satoshi Nishizuka, Lu Charboneau, Lynn Young, Sylvia Major, William C. Reinhold, Mark Waltham, Hosein Kouros-Mehr, Kimberly J. Bussey, Jae K. Lee, Virginia Espina, Peter J. Munson, Emanuel Petricoin, III, Lance A. Liotta, and John N. Weinstein

Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
PNAS 2003 100: 14229-14234; published online before print November 17 2003, 10.1073/pnas.2331323100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Susanne Idel, Hayes M. Dansky, and Jan L. Breslow

A20, a regulator of NFB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains
PNAS 2003 100: 14235-14240; published online before print November 12 2003, 10.1073/pnas.1835672100 [Abstract] [Full Text] [PDF] [Supporting Data Set]  

Ma-Li Wong, Fiona O'Kirwan, Nadia Khan, Jonas Hannestad, Kwok H. Wu, David Elashoff, Gregory Lawson, Philip W. Gold, Samuel M. McCann, and Julio Licinio

Identification, characterization, and gene expression profiling of endotoxin-induced myocarditis
PNAS 2003 100: 14241-14246; published online before print November 17 2003, 10.1073/pnas.2336220100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Laurie A. VanderVeen, Muhammed F. Hashim, Yu Shyr, and Lawrence J. Marnett

Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde
PNAS 2003 100: 14247-14252; published online before print November 5 2003, 10.1073/pnas.2332176100 [Abstract] [Full Text] [PDF]  

Sylvia Fong, Leslie Mounkes, Yong Liu, Michael Maibaum, Eric Alonzo, Pierre-Yves Desprez, Ann D. Thor, Mohammed Kashani-Sabet, and Robert J. Debs

Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family
PNAS 2003 100: 14253-14258; published online before print November 11 2003, 10.1073/pnas.2332307100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Meng Yang, Lingna Li, Ping Jiang, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman

Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells
PNAS 2003 100: 14259-14262; published online before print November 12 2003, 10.1073/pnas.2436101100 [Abstract] [Full Text] [PDF]  

Pawel J. Kolodziejski, Mohammad B. Rashid, and N. Tony Eissa

Intracellular formation of "undisruptable" dimers of inducible nitric oxide synthase
PNAS 2003 100: 14263-14268; published online before print November 12 2003, 10.1073/pnas.2435290100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Gregory Kennedy, Jun Komano, and Bill Sugden

Epstein-Barr virus provides a survival factor to Burkitt's lymphomas
PNAS 2003 100: 14269-14274; published online before print November 5 2003, 10.1073/pnas.2336099100 [Abstract] [Full Text] [PDF]  

Timothy J. Ley, Patrick J. Minx, Matthew J. Walter, Rhonda E. Ries, Hui Sun, Michael McLellan, John F. DiPersio, Daniel C. Link, Michael H. Tomasson, Timothy A. Graubert, Howard McLeod, Hanna Khoury, Mark Watson, William Shannon, Kathryn Trinkaus, Sharon Heath, James W. Vardiman, Michael A. Caligiuri, Clara D. Bloomfield, Jeffrey D. Milbrandt, Elaine R. Mardis, and Richard K. Wilson

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes
PNAS 2003 100: 14275-14280; published online before print November 12 2003, 10.1073/pnas.2335924100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

B. U. Samuel, B. Hearn, D. Mack, P. Wender, J. Rothbard, M. J. Kirisits, E. Mui, S. Wernimont, C. W. Roberts, S. P. Muench, D. W. Rice, S. T. Prigge, A. B. Law, and R. McLeod

Delivery of antimicrobials into parasites
PNAS 2003 100: 14281-14286; published online before print November 17 2003, 10.1073/pnas.2436169100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Meera Srivastava, Cristina Montagna, Ximena Leighton, Mirta Glasman, Shanmugam Naga, Ofer Eidelman, Thomas Ried, and Harvey B. Pollard

Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse
PNAS 2003 100: 14287-14292; published online before print November 7 2003, 10.1073/pnas.2235927100 [Abstract] [Full Text] [PDF]  

Charles B. Nemeroff, Christine M. Heim, Michael E. Thase, Daniel N. Klein, A. John Rush, Alan F. Schatzberg, Philip T. Ninan, James P. McCullough, Jr., Paul M. Weiss, David L. Dunner, Barbara O. Rothbaum, Susan Kornstein, Gabor Keitner, and Martin B. Keller

Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
PNAS 2003 100: 14293-14296; published online before print November 13 2003, 10.1073/pnas.2336126100 [Abstract] [Full Text] [PDF]  

M. W. Sleeman, K. Garcia, R. Liu, J. D. Murray, L. Malinova, M. Moncrieffe, G. D. Yancopoulos, and S. J. Wiegand

Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice
PNAS 2003 100: 14297-14302; published online before print November 10 2003, 10.1073/pnas.2335926100 [Abstract] [Full Text] [PDF]  

Ekambar R. Kandimalla, Lakshmi Bhagat, Fu-Gang Zhu, Dong Yu, Yan-Ping Cong, Daqing Wang, Jimmy X. Tang, Jin-Yan Tang, Cathrine F. Knetter, Egil Lien, and Sudhir Agrawal

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif
PNAS 2003 100: 14303-14308; published online before print November 10 2003, 10.1073/pnas.2335947100 [Abstract] [Full Text] [PDF] [Supporting Table]