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COMMENTARIES

Barbara L. Parsons

MED1: A central molecule for maintenance of genome integrity and response to DNA damage
PNAS 2003 100: 14601-14602; published online before print December 1 2003, 10.1073/pnas.2637169100 [Extract] [Full Text] [PDF]  
See companion article on page 15071

PERSPECTIVES

Gunte P. Wagner, Chris Amemiya, and Frank Ruddle

Hox cluster duplications and the opportunity for evolutionary novelties
PNAS 2003 100: 14603-14606; published online before print November 24 2003, 10.1073/pnas.2536656100 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

J. Patrick Shelby, John White, Karthikeyan Ganesan, Pradipsinh K. Rathod, and Daniel T. Chiu

A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes
PNAS 2003 100: 14618-14622; published online before print November 24 2003, 10.1073/pnas.2433968100 [Abstract] [Full Text] [PDF]  

Chemistry

Haimei Chen, John A. Parkinson, Olga Nováková, Juraj Bella, Fuyi Wang, Alice Dawson, Robert Gould, Simon Parsons, Viktor Brabec, and Peter J. Sadler

Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers
PNAS 2003 100: 14623-14628; published online before print December 1 2003, 10.1073/pnas.2434016100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Liming Ying, Jeremy J. Green, Haitao Li, David Klenerman, and Shankar Balasubramanian

Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer
PNAS 2003 100: 14629-14634; published online before print November 25 2003, 10.1073/pnas.2433350100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Vladimir K. Vanag and Irving R. Epstein From the Cover: Segmented spiral waves in a reaction-diffusion system PNAS 2003 100: 14635-14638; published online before print November 26 2003, 10.1073/pnas.2534816100 [Abstract] [Full Text] [PDF] [Supporting Movies]

Robert S. H. Liu and Leticia U. Colmenares

The molecular basis for the high photosensitivity of rhodopsin
PNAS 2003 100: 14639-14644; published online before print December 1 2003, 10.1073/pnas.2536769100 [Abstract] [Full Text] [PDF]  

Serguei Patchkovskii and John S. Tse

Thermodynamic stability of hydrogen clathrates
PNAS 2003 100: 14645-14650; published online before print December 1 2003, 10.1073/pnas.2430913100 [Abstract] [Full Text] [PDF]  

Lidia Cristian, James D. Lear, and William F. DeGrado

Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers
PNAS 2003 100: 14772-14777; published online before print December 1 2003, 10.1073/pnas.2536751100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Michele Vendruscolo, Emanuele Paci, Martin Karplus, and Christopher M. Dobson

Structures and relative free energies of partially folded states of proteins
PNAS 2003 100: 14817-14821; published online before print December 1 2003, 10.1073/pnas.2036516100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Howard C. Hang, Chong Yu, Darryl L. Kato, and Carolyn R. Bertozzi

A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
PNAS 2003 100: 14846-14851; published online before print December 1 2003, 10.1073/pnas.2335201100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geology

Geophysics

P. J. DeMott, D. J. Cziczo, A. J. Prenni, D. M. Murphy, S. M. Kreidenweis, D. S. Thomson, R. Borys, and D. C. Rogers

Measurements of the concentration and composition of nuclei for cirrus formation
PNAS 2003 100: 14655-14660; published online before print December 1 2003, 10.1073/pnas.2532677100 [Abstract] [Full Text] [PDF]  

Physics

Oded Hod and Eran Rabani

A coarse-grained model for a nanometer-scale molecular pump
PNAS 2003 100: 14661-14665; published online before print November 25 2003, 10.1073/pnas.2436170100 [Abstract] [Full Text] [PDF]  

Statistics

Wei Zhu, Xuena Wang, Yeming Ma, Manlong Rao, James Glimm, and John S. Kovach

Detection of cancer-specific markers amid massive mass spectral data
PNAS 2003 100: 14666-14671; published online before print December 1 2003, 10.1073/pnas.2532248100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Psychology

David C. Knight, Hanh T. Nguyen, and Peter A. Bandettini

Expression of conditional fear with and without awareness
PNAS 2003 100: 15280-15283; published online before print December 1 2003, 10.1073/pnas.2535780100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

S. L. Singla-Pareek, M. K. Reddy, and S. K. Sopory

Genetic engineering of the glyoxalase pathway in tobacco leads to enhanced salinity tolerance
PNAS 2003 100: 14672-14677; published online before print November 24 2003, 10.1073/pnas.2034667100 [Abstract] [Full Text] [PDF]  

Applied Biological Sciences

Ipsita A. Banerjee, Lingtao Yu, and Hiroshi Matsui

Cu nanocrystal growth on peptide nanotubes by biomineralization: Size control of Cu nanocrystals by tuning peptide conformation
PNAS 2003 100: 14678-14682; published online before print November 25 2003, 10.1073/pnas.2433456100 [Abstract] [Full Text] [PDF]  

Vassilios I. Sikavitsas, Gregory N. Bancroft, Heidi L. Holtorf, John A. Jansen, and Antonios G. Mikos

Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces
PNAS 2003 100: 14683-14688; published online before print December 1 2003, 10.1073/pnas.2434367100 [Abstract] [Full Text] [PDF]  

Biochemistry

Francisco J. López de Saro, Roxana E. Georgescu, and Mike O'Donnell

A peptide switch regulates DNA polymerase processivity
PNAS 2003 100: 14689-14694; published online before print November 20 2003, 10.1073/pnas.2435454100 [Abstract] [Full Text] [PDF]  

Douglas N. Roberts, Allen J. Stewart, Jason T. Huff, and Bradley R. Cairns

The RNA polymerase III transcriptome revealed by genome-wide localization and activity–occupancy relationships
PNAS 2003 100: 14695-14700; published online before print November 21 2003, 10.1073/pnas.2435566100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ken R. Rosendal, Klemens Wild, Guillermo Montoya, and Irmgard Sinning

Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication
PNAS 2003 100: 14701-14706; published online before print December 1 2003, 10.1073/pnas.2436132100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sungsoo Lee, Xiaofeng Lin, Nguyen Hai Nam, Keykavous Parang, and Gongqin Sun

Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase
PNAS 2003 100: 14707-14712; published online before print December 1 2003, 10.1073/pnas.2534493100 [Abstract] [Full Text] [PDF]  

K. Christopher Min, Rhett A. Kovall, and Wayne A. Hendrickson

Crystal structure of human -tocopherol transfer protein bound to its ligand: Implications for ataxia with vitamin E deficiency
PNAS 2003 100: 14713-14718; published online before print December 1 2003, 10.1073/pnas.2136684100 [Abstract] [Full Text] [PDF]  

Conceição A. S. A. Minetti, David P. Remeta, Holly Miller, Craig A. Gelfand, G. Eric Plum, Arthur P. Grollman, and Kenneth J. Breslauer

The thermodynamics of template-directed DNA synthesis: Base insertion and extension enthalpies
PNAS 2003 100: 14719-14724; published online before print November 17 2003, 10.1073/pnas.2336142100 [Abstract] [Full Text] [PDF]  

John B. Knight, Craig A. Eyster, Beth A. Griesel, and Ann Louise Olson

Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancer factor 2A
PNAS 2003 100: 14725-14730; published online before print November 20 2003, 10.1073/pnas.2432756100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Katsuya Shimabukuro, Ryohei Yasuda, Eiro Muneyuki, Kiyotaka Y. Hara, Kazuhiko Kinosita, Jr., and Masasuke Yoshida

Catalysis and rotation of F₁ motor: Cleavage of ATP at the catalytic site occurs in 1 ms before 40° substep rotation
PNAS 2003 100: 14731-14736; published online before print December 1 2003, 10.1073/pnas.2434983100 [Abstract] [Full Text] [PDF]  

Teresa Laragione, Valentina Bonetto, Filippo Casoni, Tania Massignan, Giancarlo Bianchi, Elisabetta Gianazza, and Pietro Ghezzi

Redox regulation of surface protein thiols: Identification of integrin -4 as a molecular target by using redox proteomics
PNAS 2003 100: 14737-14741; published online before print December 1 2003, 10.1073/pnas.2434516100 [Abstract] [Full Text] [PDF]  

Inna Nusinzon and Curt M. Horvath

Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1
PNAS 2003 100: 14742-14747; published online before print November 25 2003, 10.1073/pnas.2433987100 [Abstract] [Full Text] [PDF]  

Douglas M. Yau, Nobuhiko Yokoyama, Yoshio Goshima, Zeba K. Siddiqui, Shahid S. Siddiqui, and Tohru Kozasa

Identification and molecular characterization of the G12–Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans
PNAS 2003 100: 14748-14753; published online before print December 1 2003, 10.1073/pnas.2533143100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

O. Guryev, R. A. Carvalho, S. Usanov, A. Gilep, and R. W. Estabrook

A pathway for the metabolism of vitamin D₃: Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
PNAS 2003 100: 14754-14759; published online before print December 1 2003, 10.1073/pnas.2336107100 [Abstract] [Full Text] [PDF]  

Ayelet Maor-Shoshani, Vered Ben-Ari, and Zvi Livneh

Lesion bypass DNA polymerases replicate across non-DNA segments
PNAS 2003 100: 14760-14765; published online before print December 1 2003, 10.1073/pnas.2433503100 [Abstract] [Full Text] [PDF]  

Semira Galijasevic, Ghassan M. Saed, Michael P. Diamond, and Husam M. Abu-Soud

Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition
PNAS 2003 100: 14766-14771; published online before print December 1 2003, 10.1073/pnas.2435008100 [Abstract] [Full Text] [PDF]  

Lidia Cristian, James D. Lear, and William F. DeGrado

Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers
PNAS 2003 100: 14772-14777; published online before print December 1 2003, 10.1073/pnas.2536751100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

Voichita M. Dadarlat and Carol Beth Post

Adhesive–cohesive model for protein compressibility: An alternative perspective on stability
PNAS 2003 100: 14778-14783; published online before print November 24 2003, 10.1073/pnas.2434157100 [Abstract] [Full Text] [PDF]  

Mu Gao, David Craig, Olivier Lequin, Iain D. Campbell, Viola Vogel, and Klaus Schulten

Structure and functional significance of mechanically unfolded fibronectin type III₁ intermediates
PNAS 2003 100: 14784-14789; published online before print December 1 2003, 10.1073/pnas.2334390100 [Abstract] [Full Text] [PDF]  

Kazuo Kuwata, Tomoharu Matumoto, Hong Cheng, Kuniaki Nagayama, Thomas L. James, and Heinrich Roder

NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106–126
PNAS 2003 100: 14790-14795; published online before print December 1 2003, 10.1073/pnas.2433563100 [Abstract] [Full Text] [PDF]  

Stuart Kauffman, Carsten Peterson, Björn Samuelsson, and Carl Troein

Random Boolean network models and the yeast transcriptional network
PNAS 2003 100: 14796-14799; published online before print December 1 2003, 10.1073/pnas.2036429100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Keith Weninger, Mark E. Bowen, Steven Chu, and Axel T. Brunger

Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurations
PNAS 2003 100: 14800-14805; published online before print December 1 2003, 10.1073/pnas.2036428100 [Abstract] [Full Text] [PDF]  

Daniel B. Forger and Charles S. Peskin

A detailed predictive model of the mammalian circadian clock
PNAS 2003 100: 14806-14811; published online before print December 1 2003, 10.1073/pnas.2036281100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jorge A. Vila, Daniel R. Ripoll, and Harold A. Scheraga

Atomically detailed folding simulation of the B domain of staphylococcal protein A from random structures
PNAS 2003 100: 14812-14816; published online before print November 24 2003, 10.1073/pnas.2436463100 [Abstract] [Full Text] [PDF]  

Michele Vendruscolo, Emanuele Paci, Martin Karplus, and Christopher M. Dobson

Structures and relative free energies of partially folded states of proteins
PNAS 2003 100: 14817-14821; published online before print December 1 2003, 10.1073/pnas.2036516100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Hong Wang, Yong Yang, Mark J. Schofield, Chunwei Du, Yonatan Fridman, Susan D. Lee, Erik D. Larson, James T. Drummond, Eric Alani, Peggy Hsieh, and Dorothy A. Erie

DNA bending and unbending by MutS govern mismatch recognition and specificity
PNAS 2003 100: 14822-14827; published online before print November 21 2003, 10.1073/pnas.2433654100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sangaralingam Kumaran, Richard A. Grucza, and Gabriel Waksman

The tandem Src homology 2 domain of the Syk kinase: A molecular device that adapts to interphosphotyrosine distances
PNAS 2003 100: 14828-14833; published online before print December 1 2003, 10.1073/pnas.2432867100 [Abstract] [Full Text] [PDF]  

Marek trajbl, Avital Shurki, and Arieh Warshel

Converting conformational changes to electrostatic energy in molecular motors: The energetics of ATP synthase
PNAS 2003 100: 14834-14839; published online before print December 1 2003, 10.1073/pnas.2436328100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Richard Owczarzy, Isard Dunietz, Mark A. Behlke, Irving M. Klotz, and Joseph A. Walder

Thermodynamic treatment of oligonucleotide duplex–simplex equilibria
PNAS 2003 100: 14840-14845; published online before print December 1 2003, 10.1073/pnas.2335948100 [Abstract] [Full Text] [PDF]  

Cell Biology

Makoto Takeda, George P. Leser, Charles J. Russell, and Robert A. Lamb Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion PNAS 2003 100: 14610-14617; published online before print October 15 2003, 10.1073/pnas.2235620100 [Abstract] [Full Text] [PDF] [Supporting Information]

Howard C. Hang, Chong Yu, Darryl L. Kato, and Carolyn R. Bertozzi

A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
PNAS 2003 100: 14846-14851; published online before print December 1 2003, 10.1073/pnas.2335201100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sayyed K. Zaidi, Daniel W. Young, Shirwin M. Pockwinse, Amjad Javed, Jane B. Lian, Janet L. Stein, Andre J. van Wijnen, and Gary S. Stein

Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells
PNAS 2003 100: 14852-14857; published online before print December 1 2003, 10.1073/pnas.2533076100 [Abstract] [Full Text] [PDF]  

Simonetta Lisi, Aldo Pinchera, Robert T. McCluskey, Thomas E. Willnow, Samuel Refetoff, Claudio Marcocci, Paolo Vitti, Francesca Menconi, Lucia Grasso, Fabiana Luchetti, A. Bernard Collins, and Michele Marinò

Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: A control mechanism for thyroid hormone release
PNAS 2003 100: 14858-14863; published online before print December 1 2003, 10.1073/pnas.2432267100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Anne E. Carlson, Ruth E. Westenbroek, Timothy Quill, Dejian Ren, David E. Clapham, Bertil Hille, David L. Garbers, and Donner F. Babcock

CatSper1 required for evoked Ca²⁺ entry and control of flagellar function in sperm
PNAS 2003 100: 14864-14868; published online before print December 1 2003, 10.1073/pnas.2536658100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Timothy A. Quill, Sarah A. Sugden, Kristen L. Rossi, Lynda K. Doolittle, Robert E. Hammer, and David L. Garbers

Hyperactivated sperm motility driven by CatSper2 is required for fertilization
PNAS 2003 100: 14869-14874; published online before print December 1 2003, 10.1073/pnas.2136654100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Harold A. Fisk, Christopher P. Mattison, and Mark Winey

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
PNAS 2003 100: 14875-14880; published online before print December 1 2003, 10.1073/pnas.2434156100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Benjamin D. Yu, Michelle Becker-Hapak, Eric L. Snyder, Marc Vooijs, Catherine Denicourt, and Steven F. Dowdy

Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival
PNAS 2003 100: 14881-14886; published online before print November 20 2003, 10.1073/pnas.2431391100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Stephan P. Persengiev, Xiaochun Zhu, Bharat L. Dixit, Glenn A. Maston, Ellen L. W. Kittler, and Michael R. Green

TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed
PNAS 2003 100: 14887-14891; published online before print November 21 2003, 10.1073/pnas.2036440100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Sumitaka Hasegawa, W. Coyt Jackson, Roger Y. Tsien, and Jianghong Rao

Imaging Tetrahymena ribozyme splicing activity in single live mammalian cells
PNAS 2003 100: 14892-14896; published online before print November 25 2003, 10.1073/pnas.2036553100 [Abstract] [Full Text] [PDF]  

Takaki Shima, Shigeyuki Nada, and Masato Okada

Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts
PNAS 2003 100: 14897-14902; published online before print November 25 2003, 10.1073/pnas.2432139100 [Abstract] [Full Text] [PDF]  

E. Tzima, J. S. Reader, M. Irani-Tehrani, K. L. Ewalt, M. A. Schwartz, and P. Schimmel

Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells
PNAS 2003 100: 14903-14907; published online before print November 20 2003, 10.1073/pnas.2436330100 [Abstract] [Full Text] [PDF]  

Hong Chen, Simona Polo, Pier Paolo Di Fiore, and Pietro V. De Camilli

Rapid Ca²⁺-dependent decrease of protein ubiquitination at synapses
PNAS 2003 100: 14908-14913; published online before print December 1 2003, 10.1073/pnas.2136625100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Haibin Wang, Hiromichi Matsumoto, Yong Guo, Bibhash C. Paria, Richard L. Roberts, and Sudhansu K. Dey

Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation
PNAS 2003 100: 14914-14919; published online before print November 26 2003, 10.1073/pnas.2436379100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

L. Charles Murtaugh, Ben Z. Stanger, Kristen M. Kwan, and Douglas A. Melton

Notch signaling controls multiple steps of pancreatic differentiation
PNAS 2003 100: 14920-14925; published online before print December 1 2003, 10.1073/pnas.2436557100 [Abstract] [Full Text] [PDF]  

James Goolsby, Marie C. Marty, Dafna Heletz, Joshua Chiappelli, Gerti Tashko, Deborah Yarnell, Paul S. Fishman, Suhayl Dhib-Jalbut, Christopher T. Bever, Jr., Bernard Pessac, and David Trisler

Hematopoietic progenitors express neural genes
PNAS 2003 100: 14926-14931; published online before print November 21 2003, 10.1073/pnas.2434383100 [Abstract] [Full Text] [PDF]  

Ecology

M. B. Bonsall, E. van der Meijden, and M. J. Crawley

Contrasting dynamics in the same plant–herbivore interaction
PNAS 2003 100: 14932-14936; published online before print December 1 2003, 10.1073/pnas.2535677100 [Abstract] [Full Text] [PDF]  

Cornelis Rappoldt, Gert-Jan J. M. Pieters, Erwin B. Adema, Gerrit J. Baaijens, Ab P. Grootjans, and Cornelis J. van Duijn

Buoyancy-driven flow in a peat moss layer as a mechanism for solute transport
PNAS 2003 100: 14937-14942; published online before print December 1 2003, 10.1073/pnas.1936122100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Howard D. Rundle, Steven M. Vamosi, and Dolph Schluter

Experimental test of predation's effect on divergent selection during character displacement in sticklebacks
PNAS 2003 100: 14943-14948; published online before print November 20 2003, 10.1073/pnas.2036360100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Elisa Thébault and Michel Loreau

Food-web constraints on biodiversity–ecosystem functioning relationships
PNAS 2003 100: 14949-14954; published online before print November 24 2003, 10.1073/pnas.2434847100 [Abstract] [Full Text] [PDF]  

Evolution

Uwe Stolz, Sebastian Velez, Keith V. Wood, Monika Wood, and Jeffrey L. Feder

Darwinian natural selection for orange bioluminescent color in a Jamaican click beetle
PNAS 2003 100: 14955-14959; published online before print November 17 2003, 10.1073/pnas.2432563100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Jotun Hein, Jens Ledet Jensen, and Christian N. S. Pedersen

Recursions for statistical multiple alignment
PNAS 2003 100: 14960-14965; published online before print December 1 2003, 10.1073/pnas.2036252100 [Abstract] [Full Text] [PDF]  

Martin A. Nowak, Franziska Michor, and Yoh Iwasa

The linear process of somatic evolution
PNAS 2003 100: 14966-14969; published online before print December 1 2003, 10.1073/pnas.2535419100 [Abstract] [Full Text] [PDF]  

Tamar Kis-Papo, Valery Kirzhner, Solomon P. Wasser, and Eviatar Nevo

Evolution of genomic diversity and sex at extreme environments: Fungal life under hypersaline Dead Sea stress
PNAS 2003 100: 14970-14975; published online before print November 26 2003, 10.1073/pnas.2036284100 [Abstract] [Full Text] [PDF]  

Genetics

Eain Murphy, Dong Yu, Jane Grimwood, Jeremy Schmutz, Mark Dickson, Michael A. Jarvis, Gabriele Hahn, Jay A. Nelson, Richard M. Myers, and Thomas E. Shenk

Coding potential of laboratory and clinical strains of human cytomegalovirus
PNAS 2003 100: 14976-14981; published online before print December 1 2003, 10.1073/pnas.2136652100 [Abstract] [Full Text] [PDF]  

Valery Bliskovsky, Edward S. Ramsay, John Scott, Wendy DuBois, Wei Shi, Shuling Zhang, Xiaolan Qian, Douglas R. Lowy, and Beverly A. Mock

Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene
PNAS 2003 100: 14982-14987; published online before print November 21 2003, 10.1073/pnas.2431627100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Ayumi Matsuyama, Takeshi Shiraishi, Francesco Trapasso, Tamotsu Kuroki, Hansjuerg Alder, Masaki Mori, Kay Huebner, and Carlo M. Croce

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: Evolutionarily conserved but highly recombinogenic
PNAS 2003 100: 14988-14993; published online before print November 20 2003, 10.1073/pnas.2336256100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Francesca Storici, Christopher L. Durham, Dmitry A. Gordenin, and Michael A. Resnick

Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast
PNAS 2003 100: 14994-14999; published online before print November 20 2003, 10.1073/pnas.2036296100 [Abstract] [Full Text] [PDF] [Supporting Information]  

János Kiss, Mónika Szabó, and Ferenc Olasz

Site-specific recombination by the DDE family member mobile element IS30 transposase
PNAS 2003 100: 15000-15005. [Abstract] [Full Text] [PDF]  

Immunology

Sayed F. Abdelwahab, Fiorenza Cocchi, Kenneth C. Bagley, Roberta Kamin-Lewis, Robert C. Gallo, Anthony DeVico, and George K. Lewis

HIV-1-suppressive factors are secreted by CD4⁺ T cells during primary immune responses
PNAS 2003 100: 15006-15010; published online before print December 1 2003, 10.1073/pnas.2035075100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Domenico Mavilio, Janet Benjamin, Marybeth Daucher, Gabriella Lombardo, Shyam Kottilil, Marie A. Planta, Emanuela Marcenaro, Cristina Bottino, Lorenzo Moretta, Alessandro Moretta, and Anthony S. Fauci

Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
PNAS 2003 100: 15011-15016; published online before print November 25 2003, 10.1073/pnas.2336091100 [Abstract] [Full Text] [PDF]  

Bertrand Bellier, Véronique Thomas-Vaslin, Marie-Françoise Saron, and David Klatzmann

Turning immunological memory into amnesia by depletion of dividing T cells
PNAS 2003 100: 15017-15022; published online before print November 21 2003, 10.1073/pnas.1936194100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Nand K. Vyas, Meenakshi N. Vyas, Mary C. Chervenak, David R. Bundle, B. Mario Pinto, and Florante A. Quiocho

Structural basis of peptide–carbohydrate mimicry in an antibody-combining site
PNAS 2003 100: 15023-15028; published online before print November 25 2003, 10.1073/pnas.2431286100 [Abstract] [Full Text] [PDF]  

Vasso Apostolopoulos, Elizabeth Yuriev, Paul A. Ramsland, Jodie Halton, Carla Osinski, Wenjun Li, Magdalena Plebanski, Hans Paulsen, and Ian F. C. McKenzie

A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor
PNAS 2003 100: 15029-15034; published online before print December 1 2003, 10.1073/pnas.2432220100 [Abstract] [Full Text] [PDF]  

David A. Hildeman, Thomas Mitchell, Bruce Aronow, Sara Wojciechowski, John Kappler, and Philippa Marrack

Control of Bcl-2 expression by reactive oxygen species
PNAS 2003 100: 15035-15040; published online before print December 1 2003, 10.1073/pnas.1936213100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Qunmin Zhou, Kottil Rammohan, Shili Lin, Nikki Robinson, Ou Li, Xingluo Liu, Xue-feng Bai, Lijie Yin, Bruce Scarberry, Peishuang Du, Ming You, Kunliang Guan, Pan Zheng, and Yang Liu

CD24 is a genetic modifier for risk and progression of multiple sclerosis
PNAS 2003 100: 15041-15046; published online before print December 1 2003, 10.1073/pnas.2533866100 [Abstract] [Full Text] [PDF]  

Sophie Lucas, Nico Ghilardi, Ji Li, and Frédéric J. de Sauvage

IL-27 regulates IL-12 responsiveness of naïve CD4⁺ T cells through Stat1-dependent and -independent mechanisms
PNAS 2003 100: 15047-15052; published online before print December 1 2003, 10.1073/pnas.2536517100 [Abstract] [Full Text] [PDF]  

Laura Haynes, Sheri M. Eaton, Eve M. Burns, Troy D. Randall, and Susan L. Swain

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
PNAS 2003 100: 15053-15058; published online before print December 1 2003, 10.1073/pnas.2433717100 [Abstract] [Full Text] [PDF]  

Masahide Tone, Yukiko Tone, Elizabeth Adams, Stephen F. Yates, Mark R. Frewin, Stephen P. Cobbold, and Herman Waldmann From The Cover: Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells PNAS 2003 100: 15059-15064; published online before print November 7 2003, 10.1073/pnas.2334901100 [Abstract] [Full Text] [PDF] [Supporting Figures]

Medical Sciences

Gad Asher, Joseph Lotem, Peter Tsvetkov, Veronica Reiss, Leo Sachs, and Yosef Shaul

p53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1
PNAS 2003 100: 15065-15070; published online before print November 21 2003, 10.1073/pnas.2436329100 [Abstract] [Full Text] [PDF]  

Salvatore Cortellino, David Turner, Valeria Masciullo, Filippo Schepis, Domenico Albino, Rene Daniel, Anna Marie Skalka, Neal J. Meropol, Christophe Alberti, Lionel Larue, and Alfonso Bellacosa From The Cover: The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity PNAS 2003 100: 15071-15076; published online before print November 12 2003, 10.1073/pnas.2334585100 [Abstract] [Full Text] [PDF] [Supporting Table]   See Commentary on page 14601

Zhenyu Yue, Shengkan Jin, Chingwen Yang, Arnold J. Levine, and Nathaniel Heintz

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
PNAS 2003 100: 15077-15082; published online before print December 1 2003, 10.1073/pnas.2436255100 [Abstract] [Full Text] [PDF]  

Chetan Bettegowda, Long H. Dang, Ross Abrams, David L. Huso, Larry Dillehay, Ian Cheong, Nishant Agrawal, Scott Borzillary, J. Michael McCaffery, E. Latice Watson, Kuo-Shyan Lin, Fred Bunz, Kwamena Baidoo, Martin G. Pomper, Kenneth W. Kinzler, Bert Vogelstein, and Shibin Zhou

Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria
PNAS 2003 100: 15083-15088; published online before print December 1 2003, 10.1073/pnas.2036598100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Aron M. Troen, Esther Lutgens, Donald E. Smith, Irwin H. Rosenberg, and Jacob Selhub

The atherogenic effect of excess methionine intake
PNAS 2003 100: 15089-15094; published online before print December 1 2003, 10.1073/pnas.2436385100 [Abstract] [Full Text] [PDF]  

Shulin Wang and Wafik S. El-Deiry

Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy
PNAS 2003 100: 15095-15100; published online before print November 26 2003, 10.1073/pnas.2435285100 [Abstract] [Full Text] [PDF]  

Lixin Zhang, Yucheng Tang, Hakan Akbulut, Daniel Zelterman, Phyllis-Jean Linton, and Albert B. Deisseroth

An adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells
PNAS 2003 100: 15101-15106; published online before print November 25 2003, 10.1073/pnas.2135379100 [Abstract] [Full Text] [PDF]  

Yong Chen, Christl Ruetzler, Sruthi Pandipati, Maria Spatz, Richard M. McCarron, Kyra Becker, and John M. Hallenbeck

Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury
PNAS 2003 100: 15107-15112; published online before print November 26 2003, 10.1073/pnas.2436538100 [Abstract] [Full Text] [PDF]  

Valerie I. Brown, Junjie Fang, Keith Alcorn, Rosalind Barr, Jenny M. Kim, Robert Wasserman, and Stephan A. Grupp

Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
PNAS 2003 100: 15113-15118; published online before print December 1 2003, 10.1073/pnas.2436348100 [Abstract] [Full Text] [PDF]  

Yoshiyuki Ban, David A. Greenberg, Erlinda Concepcion, Lucy Skrabanek, Ronald Villanueva, and Yaron Tomer

Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease
PNAS 2003 100: 15119-15124; published online before print December 1 2003, 10.1073/pnas.2434175100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Microbiology

Makoto Takeda, George P. Leser, Charles J. Russell, and Robert A. Lamb Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion PNAS 2003 100: 14610-14617; published online before print October 15 2003, 10.1073/pnas.2235620100 [Abstract] [Full Text] [PDF] [Supporting Information]

Elena Dobrikova, Paola Florez, Shelton Bradrick, and Matthias Gromeier

Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region
PNAS 2003 100: 15125-15130; published online before print November 26 2003, 10.1073/pnas.2436464100 [Abstract] [Full Text] [PDF]  

Yoshiaki Nishimura, Tatsuhiko Igarashi, Nancy L. Haigwood, Reza Sadjadpour, Olivia K. Donau, Charles Buckler, Ron J. Plishka, Alicia Buckler-White, and Malcolm A. Martin

Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: Implications for HIV-1 vaccine development
PNAS 2003 100: 15131-15136; published online before print November 19 2003, 10.1073/pnas.2436476100 [Abstract] [Full Text] [PDF]  

Bruce T. Seet, Catherine A. McCaughan, Tracy M. Handel, Andrew Mercer, Craig Brunetti, Grant McFadden, and Stephen B. Fleming

Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors
PNAS 2003 100: 15137-15142; published online before print December 1 2003, 10.1073/pnas.2336648100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sean C. Brock, James R. Goldenring, and James E. Crowe, Jr.

Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells
PNAS 2003 100: 15143-15148; published online before print November 20 2003, 10.1073/pnas.2434327100 [Abstract] [Full Text] [PDF]  

Frederick Buckner, Kohei Yokoyama, Jeffrey Lockman, Kendra Aikenhead, Junko Ohkanda, Martin Sadilek, Saïd Sebti, Wesley Van Voorhis, Andrew Hamilton, and Michael H. Gelb

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents
PNAS 2003 100: 15149-15153; published online before print December 1 2003, 10.1073/pnas.2535442100 [Abstract] [Full Text]