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COMMENTARIES

Marco Barchi and Maria Jasin

Seeking new meiotic genes
PNAS 2003 100: 15287-15289; published online before print December 15 2003, 10.1073/pnas.0307283100 [Extract] [Full Text] [PDF]  
See companion article on page 15706

Catherine Denicourt and Steven F. Dowdy

Another twist in the transforming growth factor -induced cell-cycle arrest chronicle
PNAS 2003 100: 15290-15291; published online before print December 15 2003, 10.1073/pnas.0307282100 [Extract] [Full Text] [PDF]  
See companion article on page 15548

Joerg Ermann and C. Garrison Fathman

Costimulatory signals controlling regulatory T cells
PNAS 2003 100: 15292-15293; published online before print December 15 2003, 10.1073/pnas.0307001100 [Extract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

Lee-Way Jin, Kacey A. Claborn, Miki Kurimoto, Morten A. Geday, Izumi Maezawa, Faranak Sohraby, Marcus Estrada, Werner Kaminksy, and Bart Kahr

Imaging linear birefringence and dichroism in cerebral amyloid pathologies
PNAS 2003 100: 15294-15298; published online before print December 10 2003, 10.1073/pnas.2534647100 [Abstract] [Full Text] [PDF]  

J. M. Nichols, M. D. Todd, M. Seaver, S. T. Trickey, L. M. Pecora, and L. Moniz

Controlling system dimension: A class of real systems that obey the Kaplan–Yorke conjecture
PNAS 2003 100: 15299-15303; published online before print December 12 2003, 10.1073/pnas.2535197100 [Abstract] [Full Text] [PDF]  

Chemistry

Tomitake Tsukihara, Kunitoshi Shimokata, Yukie Katayama, Hideo Shimada, Kazumasa Muramoto, Hiroshi Aoyama, Masao Mochizuki, Kyoko Shinzawa-Itoh, Eiki Yamashita, Min Yao, Yuzuru Ishimura, and Shinya Yoshikawa

The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process
PNAS 2003 100: 15304-15309; published online before print December 12 2003, 10.1073/pnas.2635097100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mathematics

A. Xayaphoummine, T. Bucher, F. Thalmann, and H. Isambert

Prediction and statistics of pseudoknots in RNA structures using exactly clustered stochastic simulations
PNAS 2003 100: 15310-15315; published online before print December 15 2003, 10.1073/pnas.2536430100 [Abstract] [Full Text] [PDF]  

Antonio Córdoba and Diego Córdoba

A pointwise estimate for fractionary derivatives with applications to partial differential equations
PNAS 2003 100: 15316-15317; published online before print December 5 2003, 10.1073/pnas.2036515100 [Abstract] [Full Text] [PDF]  

Physics

Hui Deng, Gregor Weihs, David Snoke, Jacqueline Bloch, and Yoshihisa Yamamoto

Polariton lasing vs. photon lasing in a semiconductor microcavity
PNAS 2003 100: 15318-15323; published online before print December 12 2003, 10.1073/pnas.2634328100 [Abstract] [Full Text] [PDF]  

MunJu Kim, James C. Bird, Annemarie J. Van Parys, Kenneth S. Breuer, and Thomas R. Powers

A macroscopic scale model of bacterial flagellar bundling
PNAS 2003 100: 15481-15485; published online before print December 11 2003, 10.1073/pnas.2633596100 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Statistics

Paul Marjoram, John Molitor, Vincent Plagnol, and Simon Tavaré

Markov chain Monte Carlo without likelihoods
PNAS 2003 100: 15324-15328; published online before print December 8 2003, 10.1073/pnas.0306899100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Emiliano Bruner, Giorgio Manzi, and Juan Luis Arsuaga

Encephalization and allometric trajectories in the genus Homo: Evidence from the Neandertal and modern lineages
PNAS 2003 100: 15335-15340; published online before print December 12 2003, 10.1073/pnas.2536671100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Psychology

S. A. Cavigelli and M. K. McClintock

Fear of novelty in infant rats predicts adult corticosterone dynamics and an early death
PNAS 2003 100: 16131-16136; published online before print December 12 2003, 10.1073/pnas.2535721100 [Abstract] [Full Text] [PDF]  

Gerd Poeggel, Carina Helmeke, Andreas Abraham, Tina Schwabe, Patricia Friedrich, and Katharina Braun

Juvenile emotional experience alters synaptic composition in the rodent cortex, hippocampus, and lateral amygdala
PNAS 2003 100: 16137-16142; published online before print December 10 2003, 10.1073/pnas.2434663100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

Bryan C. Gibbon, Xuelu Wang, and Brian A. Larkins

Altered starch structure is associated with endosperm modification in Quality Protein Maize
PNAS 2003 100: 15329-15334; published online before print December 5 2003, 10.1073/pnas.2136854100 [Abstract] [Full Text] [PDF]  

Applied Biological Sciences

Jennifer Small, Scott J. Goetz, and Simon I. Hay

Climatic suitability for malaria transmission in Africa, 1911–1995
PNAS 2003 100: 15341-15345; published online before print December 8 2003, 10.1073/pnas.2236969100 [Abstract] [Full Text] [PDF]  

Fengfu Li, David Carlsson, Chris Lohmann, Erik Suuronen, Sandy Vascotto, Karin Kobuch, Heather Sheardown, Rejean Munger, Masatsugu Nakamura, and May Griffith

Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation
PNAS 2003 100: 15346-15351; published online before print December 5 2003, 10.1073/pnas.2536767100 [Abstract] [Full Text] [PDF]  

Ann Pearson, Meytal Budin, and Jochen J. Brocks

Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus
PNAS 2003 100: 15352-15357; published online before print December 5 2003, 10.1073/pnas.2536559100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sabine Borngraeber, Mary-Jane Budny, Grazia Chiellini, Suzana T. Cunha-Lima, Marie Togashi, Paul Webb, John D. Baxter, Thomas S. Scanlan, and Robert J. Fletterick

Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor
PNAS 2003 100: 15358-15363; published online before print December 12 2003, 10.1073/pnas.2136689100 [Abstract] [Full Text] [PDF]  

David R. Koehler, Umadevi Sajjan, Yu-Hua Chow, Bernard Martin, Geraldine Kent, A. Keith Tanswell, Colin McKerlie, Janet F. Forstner, and Jim Hu

Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia
PNAS 2003 100: 15364-15369; published online before print December 12 2003, 10.1073/pnas.2436478100 [Abstract] [Full Text] [PDF]  

Miro Smriga and Kunio Torii

L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats
PNAS 2003 100: 15370-15375; published online before print December 15 2003, 10.1073/pnas.2436556100 [Abstract] [Full Text] [PDF]  

Biochemistry

Xiang-Lei Yang, Francella J. Otero, Robert J. Skene, Duncan E. McRee, Paul Schimmel, and Lluís Ribas de Pouplana

Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
PNAS 2003 100: 15376-15380; published online before print December 11 2003, 10.1073/pnas.2136794100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Manasi Chavan, Tadashi Suzuki, Magdalena Rekowicz, and William Lennarz

Genetic, biochemical, and morphological evidence for the involvement of N-glycosylation in biosynthesis of the cell wall 1,6-glucan of Saccharomyces cerevisiae
PNAS 2003 100: 15381-15386; published online before print December 15 2003, 10.1073/pnas.2536561100 [Abstract] [Full Text] [PDF]  

Yi Wang and Jun Qin

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
PNAS 2003 100: 15387-15392; published online before print December 3 2003, 10.1073/pnas.2536810100 [Abstract] [Full Text] [PDF]  

Peter J. Unrau and David P. Bartel

An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects
PNAS 2003 100: 15393-15397; published online before print December 10 2003, 10.1073/pnas.2433147100 [Abstract] [Full Text] [PDF]  

William P. Boomershine, Craig A. McElroy, Hsin-Yue Tsai, Ross C. Wilson, Venkat Gopalan, and Mark P. Foster

Structure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase P
PNAS 2003 100: 15398-15403; published online before print December 12 2003, 10.1073/pnas.2535887100 [Abstract] [Full Text] [PDF]  

Jens Meiler and David Baker

Rapid protein fold determination using unassigned NMR data
PNAS 2003 100: 15404-15409; published online before print December 10 2003, 10.1073/pnas.2434121100 [Abstract] [Full Text] [PDF]  

Eric Jan, Terri Goss Kinzy, and Peter Sarnow

Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis
PNAS 2003 100: 15410-15415; published online before print December 12 2003, 10.1073/pnas.2535183100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Dion A. Daniels, Hang Chen, Brian J. Hicke, Kristine M. Swiderek, and Larry Gold

A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment
PNAS 2003 100: 15416-15421; published online before print December 15 2003, 10.1073/pnas.2136683100 [Abstract] [Full Text] [PDF]  

Ivan Ahel, Dragana Korencic, Michael Ibba, and Dieter Söll

Trans-editing of mischarged tRNAs
PNAS 2003 100: 15422-15427; published online before print December 8 2003, 10.1073/pnas.2136934100 [Abstract] [Full Text] [PDF]  

Christian von Mering, Evgeny M. Zdobnov, Sophia Tsoka, Francesca D. Ciccarelli, Jose B. Pereira-Leal, Christos A. Ouzounis, and Peer Bork

Genome evolution reveals biochemical networks and functional modules
PNAS 2003 100: 15428-15433; published online before print December 12 2003, 10.1073/pnas.2136809100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Klaus Godl, Josef Wissing, Alexander Kurtenbach, Peter Habenberger, Stephanie Blencke, Heidrun Gutbrod, Kostadinos Salassidis, Matthias Stein-Gerlach, Andrea Missio, Matt Cotten, and Henrik Daub

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors
PNAS 2003 100: 15434-15439; published online before print December 10 2003, 10.1073/pnas.2535024100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Hamilton O. Smith, Clyde A. Hutchison, III, Cynthia Pfannkoch, and J. Craig Venter

Generating a synthetic genome by whole genome assembly: X174 bacteriophage from synthetic oligonucleotides
PNAS 2003 100: 15440-15445; published online before print December 2 2003, 10.1073/pnas.2237126100 [Abstract] [Full Text] [PDF]  

Jessica M. Jones and Martin Gellert

Autoubiquitylation of the V(D)J recombinase protein RAG1
PNAS 2003 100: 15446-15451; published online before print December 11 2003, 10.1073/pnas.2637012100 [Abstract] [Full Text] [PDF]  

Qibing Zhou and Steven E. Rokita

A general strategy for target-promoted alkylation in biological systems
PNAS 2003 100: 15452-15457; published online before print December 12 2003, 10.1073/pnas.2533112100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yoojin Kim, Denia Ramirez-Montealegre, and David A. Pearce

A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease
PNAS 2003 100: 15458-15462; published online before print December 5 2003, 10.1073/pnas.2136651100 [Abstract] [Full Text] [PDF]  

Marcus Fändrich, Vincent Forge, Katrin Buder, Marlis Kittler, Christopher M. Dobson, and Stephan Diekmann

Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments
PNAS 2003 100: 15463-15468; published online before print December 9 2003, 10.1073/pnas.0303758100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Ekaterina Sosunova, Vasily Sosunov, Maxim Kozlov, Vadim Nikiforov, Alex Goldfarb, and Arkady Mustaev

Donation of catalytic residues to RNA polymerase active center by transcription factor Gre
PNAS 2003 100: 15469-15474; published online before print December 10 2003, 10.1073/pnas.2536698100 [Abstract] [Full Text] [PDF]  

Biophysics

A. Xayaphoummine, T. Bucher, F. Thalmann, and H. Isambert

Prediction and statistics of pseudoknots in RNA structures using exactly clustered stochastic simulations
PNAS 2003 100: 15310-15315; published online before print December 15 2003, 10.1073/pnas.2536430100 [Abstract] [Full Text] [PDF]  

Swarnalatha Y. Reddy, Satoshi Obika, and Thomas C. Bruice

Conformations and dynamics of Ets-1 ETS domain–DNA complexes
PNAS 2003 100: 15475-15480; published online before print December 12 2003, 10.1073/pnas.1936251100 [Abstract] [Full Text] [PDF] [Supporting Information]  

MunJu Kim, James C. Bird, Annemarie J. Van Parys, Kenneth S. Breuer, and Thomas R. Powers

A macroscopic scale model of bacterial flagellar bundling
PNAS 2003 100: 15481-15485; published online before print December 11 2003, 10.1073/pnas.2633596100 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Yongjin Zhu, Darwin O. V. Alonso, Kosuke Maki, Cheng-Yen Huang, Steven J. Lahr, Valerie Daggett, Heinrich Roder, William F. DeGrado, and Feng Gai

Ultrafast folding of ₃D: A de novo designed three-helix bundle protein
PNAS 2003 100: 15486-15491; published online before print December 11 2003, 10.1073/pnas.2136623100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Yan Chen, Li-Na Wei, and Joachim D. Müller

Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy
PNAS 2003 100: 15492-15497; published online before print December 12 2003, 10.1073/pnas.2533045100 [Abstract] [Full Text] [PDF]  

Li-Qun Gu, Stephen Cheley, and Hagan Bayley

Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore
PNAS 2003 100: 15498-15503; published online before print December 15 2003, 10.1073/pnas.2531778100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Paul J. A. Erbel, Paul B. Card, Ozgur Karakuzu, Richard K. Bruick, and Kevin H. Gardner

Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor
PNAS 2003 100: 15504-15509; published online before print December 10 2003, 10.1073/pnas.2533374100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sietse M. van Netten, Theo Dinklo, Walter Marcotti, and Corné J. Kros

Channel gating forces govern accuracy of mechano-electrical transduction in hair cells
PNAS 2003 100: 15510-15515; published online before print December 10 2003, 10.1073/pnas.2632626100 [Abstract] [Full Text] [PDF]  

M. Margittai, J. Widengren, E. Schweinberger, G. F. Schröder, S. Felekyan, E. Haustein, M. König, D. Fasshauer, H. Grubmüller, R. Jahn, and C. A. M. Seidel

Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1
PNAS 2003 100: 15516-15521; published online before print December 10 2003, 10.1073/pnas.2331232100 [Abstract] [Full Text] [PDF] [Supporting Information]  

James C. Liao, Riccardo Boscolo, Young-Lyeol Yang, Linh My Tran, Chiara Sabatti, and Vwani P. Roychowdhury

Network component analysis: Reconstruction of regulatory signals in biological systems
PNAS 2003 100: 15522-15527; published online before print December 12 2003, 10.1073/pnas.2136632100 [Abstract] [Full Text] [PDF] [Supporting Appendixes]  

Saori Maki-Yonekura, Koji Yonekura, and Keiichi Namba

Domain movements of HAP2 in the cap–filament complex formation and growth process of the bacterial flagellum
PNAS 2003 100: 15528-15533; published online before print December 12 2003, 10.1073/pnas.2534343100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Clemens Hofmann, Thijs J. Aartsma, Hartmut Michel, and Jürgen Köhler

Direct observation of tiers in the energy landscape of a chromoprotein: A single-molecule study
PNAS 2003 100: 15534-15538; published online before print December 11 2003, 10.1073/pnas.2533896100 [Abstract] [Full Text] [PDF]  

Bryan Schmidt, John McCracken, and Shelagh Ferguson-Miller

A discrete water exit pathway in the membrane protein cytochrome c oxidase
PNAS 2003 100: 15539-15542; published online before print December 5 2003, 10.1073/pnas.2633243100 [Abstract] [Full Text] [PDF]  

Andreas Namslauer, Ashtamurthy S. Pawate, Robert B. Gennis, and Peter Brzezinski

Redox-coupled proton translocation in biological systems: Proton shuttling in cytochrome c oxidase
PNAS 2003 100: 15543-15547; published online before print December 15 2003, 10.1073/pnas.2432106100 [Abstract] [Full Text] [PDF]  

Cell Biology

Katharina Gaus, Enrico Gratton, Eleanor P. W. Kable, Allan S. Jones, Ingrid Gelissen, Leonard Kritharides, and Wendy Jessup

Visualizing lipid structure and raft domains in living cells with two-photon microscopy
PNAS 2003 100: 15554-15559; published online before print December 12 2003, 10.1073/pnas.2534386100 [Abstract] [Full Text] [PDF]  

Amy Duffield, Erik-Jan Kamsteeg, Andrea N. Brown, Philipp Pagel, and Michael J. Caplan

The tetraspanin CD63 enhances the internalization of the H,K-ATPase -subunit
PNAS 2003 100: 15560-15565; published online before print December 5 2003, 10.1073/pnas.2536699100 [Abstract] [Full Text] [PDF]  

Vargheese Chennathukuzhi, Carlos R. Morales, Mohamed El-Alfy, and Norman B. Hecht

The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells
PNAS 2003 100: 15566-15571; published online before print December 12 2003, 10.1073/pnas.2536695100 [Abstract] [Full Text] [PDF]  

Julia Shackelford, Christopher Maier, and Joseph S. Pagano

Epstein–Barr virus activates -catenin in type III latently infected B lymphocyte lines: Association with deubiquitinating enzymes
PNAS 2003 100: 15572-15576; published online before print December 8 2003, 10.1073/pnas.2636947100 [Abstract] [Full Text] [PDF]  

Shigeru Chiba, Kenichi Takeshita, Yoichi Imai, Keiki Kumano, Mineo Kurokawa, Shigeo Masuda, Kiyoshi Shimizu, Shuji Nakamura, Frank H. Ruddle, and Hisamaru Hirai

Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells
PNAS 2003 100: 15577-15582; published online before print December 11 2003, 10.1073/pnas.2536757100 [Abstract] [Full Text] [PDF]  

Gerbrand Koster, Martijn VanDuijn, Bas Hofs, and Marileen Dogterom From the Cover: Membrane tube formation from giant vesicles by dynamic association of motor proteins PNAS 2003 100: 15583-15588; published online before print December 8 2003, 10.1073/pnas.2531786100 [Abstract] [Full Text] [PDF]

Jonathan D. Trent, Hiromi K. Kagawa, Chad D. Paavola, R. Andrew McMillan, Jeanie Howard, Linda Jahnke, Colleen Lavin, Tsegereda Embaye, and Christopher E. Henze

Intracellular localization of a group II chaperonin indicates a membrane-related function
PNAS 2003 100: 15589-15594; published online before print December 12 2003, 10.1073/pnas.2136795100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Micah Luftig, Efthimios Prinarakis, Teruhito Yasui, Theodore Tsichritzis, Ellen Cahir-McFarland, Jun-Ichiro Inoue, Hiroyasu Nakano, Tak Wah Mak, Wen-Chen Yeh, Xiaoxia Li, Shizuo Akira, Nobutaka Suzuki, Shinobu Suzuki, George Mosialos, and Elliott Kieff

Epstein–Barr virus latent membrane protein 1 activation of NF-B through IRAK1 and TRAF6
PNAS 2003 100: 15595-15600; published online before print December 12 2003, 10.1073/pnas.2136756100 [Abstract] [Full Text] [PDF]  

Thanh U. Barbie, David A. Barbie, David T. MacLaughlin, Shyamala Maheswaran, and Patricia K. Donahoe

Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107
PNAS 2003 100: 15601-15606; published online before print December 11 2003, 10.1073/pnas.2636900100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Mirka Uhlirova, Brian D. Foy, Barry J. Beaty, Ken E. Olson, Lynn M. Riddiford, and Marek Jindra

Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis
PNAS 2003 100: 15607-15612; published online before print December 10 2003, 10.1073/pnas.2136837100 [Abstract] [Full Text] [PDF]  

Charles W. Heilig, Thomas Saunders, Frank C. Brosius, III, Kelle Moley, Kathleen Heilig, Raymond Baggs, LiRong Guo, and David Conner

Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy
PNAS 2003 100: 15613-15618; published online before print December 12 2003, 10.1073/pnas.2536196100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Bertrand Joseph, Åsa Wallén-Mackenzie, Gérard Benoit, Takashi Murata, Eliza Joodmardi, Sam Okret, and Thomas Perlmann

p57^Kip2 cooperates with Nurr1 in developing dopamine cells
PNAS 2003 100: 15619-15624; published online before print December 11 2003, 10.1073/pnas.2635658100 [Abstract] [Full Text] [PDF]  

Howard Green, Karen Easley, and Shiro Iuchi

Marker succession during the development of keratinocytes from cultured human embryonic stem cells
PNAS 2003 100: 15625-15630; published online before print December 8 2003, 10.1073/pnas.0307226100 [Abstract] [Full Text] [PDF]  

Anne Dell, Sara Chalabi, Richard L. Easton, Stuart M. Haslam, Mark Sutton-Smith, Manish S. Patankar, Frank Lattanzio, Maria Panico, Howard R. Morris, and Gary F. Clark

Murine and human zona pellucida 3 derived from mouse eggs express identical O-glycans
PNAS 2003 100: 15631-15636; published online before print December 12 2003, 10.1073/pnas.2635507100 [Abstract] [Full Text] [PDF]  

Masanori Hirashima, Yong Lu, Lois Byers, and Janet Rossant

Trophoblast expression of fms-like tyrosine kinase 1 is not required for the establishment of the maternal–fetal interface in the mouse placenta
PNAS 2003 100: 15637-15642; published online before print December 10 2003, 10.1073/pnas.2635424100 [Abstract] [Full Text] [PDF]  

Ecology

Brian R. Silliman and Steven Y. Newell

Fungal farming in a snail
PNAS 2003 100: 15643-15648; published online before print December 4 2003, 10.1073/pnas.2535227100 [Abstract] [Full Text] [PDF]  

A. Elizabeth Arnold, Luis Carlos Mejía, Damond Kyllo, Enith I. Rojas, Zuleyka Maynard, Nancy Robbins, and Edward Allen Herre

Fungal endophytes limit pathogen damage in a tropical tree
PNAS 2003 100: 15649-15654; published online before print December 11 2003, 10.1073/pnas.2533483100 [Abstract] [Full Text] [PDF]  

Evolution

Aoife McLysaght, Pierre F. Baldi, and Brandon S. Gaut

Extensive gene gain associated with adaptive evolution of poxviruses
PNAS 2003 100: 15655-15660; published online before print December 5 2003, 10.1073/pnas.2136653100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Jing Yang, Richard Lusk, and Wen-Hsiung Li

Organismal complexity, protein complexity, and gene duplicability
PNAS 2003 100: 15661-15665; published online before print December 5 2003, 10.1073/pnas.2536672100 [Abstract] [Full Text] [PDF]  

Sanjay Anand, Wayne C. H. Wang, Dennis R. Powell, Stacey A. Bolanowski, Jian Zhang, Christina Ledje, Aruna B. Pawashe, Chris T. Amemiya, and Cooduvalli S. Shashikant

Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes
PNAS 2003 100: 15666-15669; published online before print December 12 2003, 10.1073/pnas.2535667100 [Abstract] [Full Text] [PDF]  

Scott Kroken, N. Louise Glass, John W. Taylor, O. C. Yoder, and B. Gillian Turgeon

Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes
PNAS 2003 100: 15670-15675; published online before print December 15 2003, 10.1073/pnas.2532165100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Eric W. Brown, Mark K. Mammel, J. Eugene LeClerc, and Thomas A. Cebula

Limited boundaries for extensive horizontal gene transfer among Salmonella pathogens
PNAS 2003 100: 15676-15681; published online before print December 11 2003, 10.1073/pnas.2634406100 [Abstract] [Full Text] [PDF]  

Richard C. Moore and Michael D. Purugganan

The early stages of duplicate gene evolution
PNAS 2003 100: 15682-15687; published online before print December 11 2003, 10.1073/pnas.2535513100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yi-Kuo Yu, John C. Wootton, and Stephen F. Altschul

The compositional adjustment of amino acid substitution matrices
PNAS 2003 100: 15688-15693; published online before print December 8 2003, 10.1073/pnas.2533904100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Dale H. Clayton, Sarah E. Bush, Brad M. Goates, and Kevin P. Johnson

Host defense reinforces host–parasite cospeciation
PNAS 2003 100: 15694-15699; published online before print December 12 2003, 10.1073/pnas.2533751100 [Abstract] [Full Text] [PDF]  

Timothy A. Rawlings, Timothy M. Collins, and Rüdiger Bieler

Changing identities: tRNA duplication and remolding within animal mitochondrial genomes
PNAS 2003 100: 15700-15705; published online before print December 12 2003, 10.1073/pnas.2535036100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Weimin He, Yaacov Barak, Andrea Hevener, Peter Olson, Debbie Liao, Jamie Le, Michael Nelson, Estelita Ong, Jerrold M. Olefsky, and Ronald M. Evans

Adipose-specific peroxisome proliferator-activated receptor knockout causes insulin resistance in fat and liver but not in muscle
PNAS 2003 100: 15712-15717; published online before print December 5 2003, 10.1073/pnas.2536828100 [Abstract] [Full Text] [PDF]  

Hideo Matsumura, Stefanie Reich, Akiko Ito, Hiromasa Saitoh, Sophien Kamoun, Peter Winter, Günter Kahl, Monika Reuter, Detlev H. Krüger, and Ryohei Terauchi

Gene expression analysis of plant host–pathogen interactions by SuperSAGE
PNAS 2003 100: 15718-15723; published online before print December 15 2003, 10.1073/pnas.2536670100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jonas Warringer, Elke Ericson, Luciano Fernandez, Olle Nerman, and Anders Blomberg

High-resolution yeast phenomics resolves different physiological features in the saline response
PNAS 2003 100: 15724-15729; published online before print December 15 2003, 10.1073/pnas.2435976100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Daniela Ahlert, Stephanie Ruf, and Ralph Bock

Plastid protein synthesis is required for plant development in tobacco
PNAS 2003 100: 15730-15735; published online before print December 5 2003, 10.1073/pnas.2533668100 [Abstract] [Full Text] [PDF]  

Derek T. Scholes, Alison E. Kenny, Eric R. Gamache, Zhongming Mou, and M. Joan Curcio

Activation of a LTR-retrotransposon by telomere erosion
PNAS 2003 100: 15736-15741; published online before print December 12 2003, 10.1073/pnas.2136609100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kenji Ichiyanagi, Arthur Beauregard, and Marlene Belfort

A bacterial group II intron favors retrotransposition into plasmid targets
PNAS 2003 100: 15742-15747; published online before print December 12 2003, 10.1073/pnas.2536659100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Nina Costantino and Donald L. Court

Enhanced levels of Red-mediated recombinants in mismatch repair mutants
PNAS 2003 100: 15748-15753; published online before print December 12 2003, 10.1073/pnas.2434959100 [Abstract] [Full Text] [PDF]  

Austin L. Hughes, Bernice Packer, Robert Welch, Andrew W. Bergen, Stephen J. Chanock, and Meredith Yeager

Widespread purifying selection at polymorphic sites in human protein-coding loci
PNAS 2003 100: 15754-15757; published online before print December 5 2003, 10.1073/pnas.2536718100 [Abstract] [Full Text] [PDF]  

Sam Holmstrom, Mary E. Van Antwerp, and Jorge A. Iñiguez-Lluhí

Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy
PNAS 2003 100: 15758-15763; published online before print December 8 2003, 10.1073/pnas.2136933100 [Abstract] [Full Text] [PDF]  

David B. Kushner, Brett D. Lindenbach, Valery Z. Grdzelishvili, Amine O. Noueiry, Scott M. Paul, and Paul Ahlquist

Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus
PNAS 2003 100: 15764-15769; published online before print December 11 2003, 10.1073/pnas.2536857100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Yufuko Akamatsu, Dorota Dziadkowiec, Mitsunori Ikeguchi, Hideo Shinagawa, and Hiroshi Iwasaki

Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast
PNAS 2003 100: 15770-15775; published online before print December 8 2003, 10.1073/pnas.2632890100 [Abstract] [Full Text] [PDF]  

Toshiyuki Shiraki, Shinji Kondo, Shintaro Katayama, Kazunori Waki, Takeya Kasukawa, Hideya Kawaji, Rimantas Kodzius, Akira Watahiki, Mari Nakamura, Takahiro Arakawa, Shiro Fukuda, Daisuke Sasaki, Anna Podhajska, Matthias Harbers, Jun Kawai, Piero Carninci, and Yoshihide Hayashizaki

Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage
PNAS 2003 100: 15776-15781; published online before print December 8 2003, 10.1073/pnas.2136655100 [Abstract] [Full Text] [PDF]  

Jianhua Zhang, Mei Dong, Lily Li, Yunxia Fan, Purnima Pathre, Jin Dong, Danwen Lou, James M. Wells, Danyvid Olivares-Villagómez, Luc Van Kaer, Xiaodong Wang, and Ming Xu

Endonuclease G is required for early embryogenesis and normal apoptosis in mice
PNAS 2003 100: 15782-15787; published online before print December 8 2003, 10.1073/pnas.2636393100 [Abstract] [Full Text] [PDF]  

Shunji Tomatsu, Koji O. Orii, Robert E. Fleming, Christopher C. Holden, Abdul Waheed, Robert S. Britton, Monica A. Gutierrez, Susana Velez-Castrillon, Bruce R. Bacon, and William S. Sly

Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis
PNAS 2003 100: 15788-15793; published online before print December 12 2003, 10.1073/pnas.2237037100 [Abstract] [Full Text] [PDF]  

Karen T. Chang, Yi-Jun Shi, and Kyung-Tai Min

The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: Implications for mental retardation
PNAS 2003 100: 15794-15799; published online before print December 10 2003, 10.1073/pnas.2536696100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Bertrand Goudeau, François Huetz, Sandrine Samson, James P. Di Santo, Ana Cumano, Amer Beg, Alain Israël, and Sylvie Mémet

IB/IB deficiency reveals that a critical NF-B dosage is required for lymphocyte survival
PNAS 2003 100: 15800-15805; published online before print December 9 2003, 10.1073/pnas.2535880100 [Abstract] [Full Text] [PDF]  

Marie-Alexandra Alyanakian, Sylvaine You, Diane Damotte, Christine Gouarin, Anne Esling, Corinne Garcia, Séverine Havouis, Lucienne Chatenoud, and Jean-François Bach

Diversity of regulatory CD4^+T cells controlling distinct organ-specific autoimmune diseases
PNAS 2003 100: 15806-15811; published online before print December 12 2003, 10.1073/pnas.2636971100 [Abstract] [Full Text] [PDF]  

Ping Zhu, Elena Chertova, Julian Bess, Jr., Jeffrey D. Lifson, Larry O. Arthur, Jun Liu, Kenneth A. Taylor, and Kenneth H. Roux

Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions
PNAS 2003 100: 15812-15817; published online before print December 10 2003, 10.1073/pnas.2634931100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Brandon M. Sullivan, Amy Juedes, Susanne J. Szabo, Matthias von Herrath, and Laurie H. Glimcher

Antigen-driven effector CD8 T cell function regulated by T-bet
PNAS 2003 100: 15818-15823; published online before print December 12 2003, 10.1073/pnas.2636938100 [Abstract] [Full Text] [PDF]  

Bei Liu, Jie Dai, Hong Zheng, Diliana Stoilova, Shaoli Sun, and Zihai Li

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases
PNAS 2003 100: 15824-15829; published online before print December 10 2003, 10.1073/pnas.2635458100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Marika C. Kullberg, John F. Andersen, Peter L. Gorelick, Patricia Caspar, Sebastian Suerbaum, James G. Fox, Allen W. Cheever, Dragana Jankovic, and Alan Sher

Induction of colitis by a CD4⁺ T cell clone specific for a bacterial epitope
PNAS 2003 100: 15830-15835; published online before print December 12 2003, 10.1073/pnas.2534546100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Medical Sciences

Celia A. Kanashiro, Andrew V. Schally, Kate Groot, Patricia Armatis, Andrea L. F. Bernardino, and Jozsef L. Varga

Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin
PNAS 2003 100: 15836-15841; published online before print December 5 2003, 10.1073/pnas.2536558100 [Abstract] [Full Text] [PDF]  

Neil M. Wolfman, Alexandra C. McPherron, William N. Pappano, Monique V. Davies, Kening Song, Kathleen N. Tomkinson, Jill F. Wright, Liz Zhao, Suzanne M. Sebald, Daniel S. Greenspan, and Se-Jin Lee

Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases
PNAS 2003 100: 15842-15846; published online before print December 11 2003, 10.1073/pnas.2534946100 [Abstract] [Full Text] [PDF]  

Juan F. Medina, Sergio Recalde, Jesús Prieto, Jon Lecanda, Elena Sáez, Colin D. Funk, Paola Vecino, Marian A. van Roon, Roelof Ottenhoff, Piter J. Bosma, Conny T. Bakker, and Ronald P. J. Oude Elferink

Anion exchanger 2 is essential for spermiogenesis in mice
PNAS 2003 100: 15847-15852; published online before print December 12 2003, 10.1073/pnas.2536127100 [Abstract] [Full Text] [PDF]  

Yi Li, Bryan Welm, Katrina Podsypanina, Shixia Huang, Mario Chamorro, Xiaomei Zhang, Tracey Rowlands, Mikala Egeblad, Pam Cowin, Zena Werb, Lee K. Tan, Jeffrey M. Rosen, and Harold E. Varmus