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COMMENTARIES

William Martin and Piet Borst

Secondary loss of chloroplasts in trypanosomes
PNAS 2003 100: 765-767; published online before print January 27 2003, 10.1073/pnas.0437776100 [Extract] [Full Text] [PDF]  
See companion article on page 1067

John P. Cooke

Flow, NO, and atherogenesis
PNAS 2003 100: 768-770; published online before print January 27 2003, 10.1073/pnas.0430082100 [Extract] [Full Text] [PDF]  
See companion article on page 1420

Mark J. Solomon

Hysteresis meets the cell cycle
PNAS 2003 100: 771-772; published online before print January 27 2003, 10.1073/pnas.0430083100 [Extract] [Full Text] [PDF]  
See companion article on page 975

Judy Hirst

The dichotomy of complex I: A sodium ion pump or a proton pump
PNAS 2003 100: 773-775; published online before print January 27 2003, 10.1073/pnas.0330050100 [Extract] [Full Text] [PDF]  
See companion article on page 839

PERSPECTIVES

Lawrence A. Loeb, Keith R. Loeb, and Jon P. Anderson

Multiple mutations and cancer
PNAS 2003 100: 776-781; published online before print January 27 2003, 10.1073/pnas.0334858100 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Markos A. Katsoulakis, Andrew J. Majda, and Dionisios G. Vlachos

Coarse-grained stochastic processes for microscopic lattice systems
PNAS 2003 100: 782-787; published online before print January 27 2003, 10.1073/pnas.242741499 [Abstract] [Full Text] [PDF]  

Ramon Ferrer i Cancho and Ricard V. Solé

Least effort and the origins of scaling in human language
PNAS 2003 100: 788-791; published online before print January 22 2003, 10.1073/pnas.0335980100 [Abstract] [Full Text] [PDF]  

Chemistry

Dimiter N. Petsev, Kai Chen, Olga Gliko, and Peter G. Vekilov

Diffusion-limited kinetics of the solution-solid phase transition of molecular substances
PNAS 2003 100: 792-796; published online before print January 24 2003, 10.1073/pnas.0333065100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tony Kwok-Kong Mong, Hing-Ken Lee, Sergio G. Durón, and Chi-Huey Wong

Reactivity-based one-pot total synthesis of fucose GM₁ oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer
PNAS 2003 100: 797-802; published online before print January 27 2003, 10.1073/pnas.0337590100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Nobuo Maeda, Jacob N. Israelachvili, and Mika M. Kohonen

Evaporation and instabilities of microscopic capillary bridges
PNAS 2003 100: 803-808; published online before print January 21 2003, 10.1073/pnas.0234283100 [Abstract] [Full Text] [PDF]  

W. Yang, Y. Q. Gao, Q. Cui, J. Ma, and M. Karplus

The missing link between thermodynamics and structure in F₁-ATPase
PNAS 2003 100: 874-879; published online before print January 27 2003, 10.1073/pnas.0337432100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Onofrio Annunziata, Olutayo Ogun, and George B. Benedek

Observation of liquid-liquid phase separation for eye lens S-crystallin
PNAS 2003 100: 970-974; published online before print January 15 2003, 10.1073/pnas.242746499 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Agricultural Sciences

Russell A. Jurenka, Mitko Subchev, José-Luis Abad, Man-Yeon Choi, and Gemma Fabriàs

Sex pheromone biosynthetic pathway for disparlure in the gypsy moth, Lymantria dispar
PNAS 2003 100: 809-814; published online before print January 17 2003, 10.1073/pnas.0236060100 [Abstract] [Full Text] [PDF]  

Applied Biological Sciences

Helen W. Kreuzer-Martin, Michael J. Lott, Janet Dorigan, and James R. Ehleringer

Microbe forensics: Oxygen and hydrogen stable isotope ratios in Bacillus subtilis cells and spores
PNAS 2003 100: 815-819; published online before print January 27 2003, 10.1073/pnas.252747799 [Abstract] [Full Text] [PDF]  

Omar A. Saleh and Lydia L. Sohn

Direct detection of antibody-antigen binding using an on-chip artificial pore
PNAS 2003 100: 820-824; published online before print January 27 2003, 10.1073/pnas.0337563100 [Abstract] [Full Text] [PDF] [Supporting Text]  

T. B. Causey, S. Zhou, K. T. Shanmugam, and L. O. Ingram Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Engineering the metabolism of Escherichia coli W3110 for the conversion of sugar to redox-neutral and oxidized products: Homoacetate production PNAS 2003 100: 825-832; published online before print January 29 2003, 10.1073/pnas.0337684100 [Abstract] [Full Text] [PDF]

Biochemistry

Dimiter N. Petsev, Kai Chen, Olga Gliko, and Peter G. Vekilov

Diffusion-limited kinetics of the solution-solid phase transition of molecular substances
PNAS 2003 100: 792-796; published online before print January 24 2003, 10.1073/pnas.0333065100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Isabelle Dussault, Hye-Dong Yoo, Min Lin, Eric Wang, Ming Fan, Ashok K. Batta, Gerald Salen, Sandra K. Erickson, and Barry M. Forman

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance
PNAS 2003 100: 833-838; published online before print January 13 2003, 10.1073/pnas.0236235100 [Abstract] [Full Text] [PDF]  

Anja C. Gemperli, Peter Dimroth, and Julia Steuber From the Cover: Sodium ion cycling mediates energy coupling between complex I and ATP synthase PNAS 2003 100: 839-844; published online before print January 21 2003, 10.1073/pnas.0237328100 [Abstract] [Full Text] [PDF]   See Commentary on page 773

Yanan Hu, Lan Chen, Sha Ha, Ben Gross, Brian Falcone, Deborah Walker, Maryam Mokhtarzadeh, and Suzanne Walker

Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases
PNAS 2003 100: 845-849; published online before print January 21 2003, 10.1073/pnas.0235749100 [Abstract] [Full Text] [PDF]  

Qi-Qun Tang, Tamara C. Otto, and M. Daniel Lane

CCAAT/enhancer-binding protein is required for mitotic clonal expansion during adipogenesis
PNAS 2003 100: 850-855; published online before print January 13 2003, 10.1073/pnas.0337434100 [Abstract] [Full Text] [PDF]  

Jun Yin, Scott E. Andryski, Albert E. Beuscher, IV, Raymond C. Stevens, and Peter G. Schultz

Structural evidence for substrate strain in antibody catalysis
PNAS 2003 100: 856-861; published online before print January 24 2003, 10.1073/pnas.0235873100 [Abstract] [Full Text] [PDF]  

Markus Hartmann, Thomas R. Schneider, Andrea Pfeil, Gabriele Heinrich, William N. Lipscomb, and Gerhard H. Braus

Evolution of feedback-inhibited / barrel isoenzymes by gene duplication and a single mutation
PNAS 2003 100: 862-867; published online before print January 22 2003, 10.1073/pnas.0337566100 [Abstract] [Full Text] [PDF]  

Cindy R. Sinars, Joyce Cheung-Flynn, Ronald A. Rimerman, Jonathan G. Scammell, David F. Smith, and Jon Clardy

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes
PNAS 2003 100: 868-873; published online before print January 21 2003, 10.1073/pnas.0231020100 [Abstract] [Full Text] [PDF]  

W. Yang, Y. Q. Gao, Q. Cui, J. Ma, and M. Karplus

The missing link between thermodynamics and structure in F₁-ATPase
PNAS 2003 100: 874-879; published online before print January 27 2003, 10.1073/pnas.0337432100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Débora Bonenfant, Tobias Schmelzle, Estela Jacinto, José L. Crespo, Thierry Mini, Michael N. Hall, and Paul Jenoe

Quantitation of changes in protein phosphorylation: A simple method based on stable isotope labeling and mass spectrometry
PNAS 2003 100: 880-885; published online before print January 22 2003, 10.1073/pnas.232735599 [Abstract] [Full Text] [PDF] [Supporting Table]  

Jing Li, Lei Shi, and Arthur Karlin

A photochemical approach to the lipid accessibility of engineered cysteinyl residues
PNAS 2003 100: 886-891; published online before print January 17 2003, 10.1073/pnas.0237311100 [Abstract] [Full Text] [PDF]  

Gertraud Burger, Lise Forget, Yun Zhu, Michael W. Gray, and B. Franz Lang

Unique mitochondrial genome architecture in unicellular relatives of animals
PNAS 2003 100: 892-897; published online before print January 24 2003, 10.1073/pnas.0336115100 [Abstract] [Full Text] [PDF]  

Alexander M. Makhov, Sam S.-K. Lee, I. Robert Lehman, and Jack D. Griffith

Origin-specific unwinding of herpes simplex virus 1 DNA by the viral UL9 and ICP8 proteins: Visualization of a specific preunwinding complex
PNAS 2003 100: 898-903; published online before print January 24 2003, 10.1073/pnas.0237171100 [Abstract] [Full Text] [PDF]  

Feng Shao, Panayiotis O. Vacratsis, Zhaoqin Bao, Katherine E. Bowers, Carol A. Fierke, and Jack E. Dixon

Biochemical characterization of the Yersinia YopT protease: Cleavage site and recognition elements in Rho GTPases
PNAS 2003 100: 904-909; published online before print January 21 2003, 10.1073/pnas.252770599 [Abstract] [Full Text] [PDF]  

Eli Chapman, Marian C. Bryan, and Chi-Huey Wong

Mechanistic studies of -arylsulfotransferase IV
PNAS 2003 100: 910-915; published online before print January 23 2003, 10.1073/pnas.0337638100 [Abstract] [Full Text] [PDF]  

Alan Charest, Vicky Kheifets, Julie Park, Keara Lane, Kevin McMahon, Cathy L. Nutt, and David Housman

Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma
PNAS 2003 100: 916-921; published online before print January 21 2003, 10.1073/pnas.242741799 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

Bora Inceoglu, Jozsef Lango, Jie Jing, Lili Chen, Fuat Doymaz, Isaac N. Pessah, and Bruce D. Hammock

One scorpion, two venoms: Prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action
PNAS 2003 100: 922-927; published online before print January 27 2003, 10.1073/pnas.242735499 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Nabil G. Seidah, Suzanne Benjannet, Louise Wickham, Jadwiga Marcinkiewicz, Stéphanie Bélanger Jasmin, Stefano Stifani, Ajoy Basak, Annik Prat, and Michel Chrétien

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
PNAS 2003 100: 928-933; published online before print January 27 2003, 10.1073/pnas.0335507100 [Abstract] [Full Text] [PDF]  

Oliver Schröder, E. Peter Geiduschek, and George A. Kassavetis

A single-stranded promoter for RNA polymerase III
PNAS 2003 100: 934-939; published online before print January 21 2003, 10.1073/pnas.242735699 [Abstract] [Full Text] [PDF]  

George S. Baillie, Arvind Sood, Ian McPhee, Irene Gall, Stephen J. Perry, Robert J. Lefkowitz, and Miles D. Houslay

-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates -adrenoceptor switching from G_s to G_i
PNAS 2003 100: 940-945; published online before print January 27 2003, 10.1073/pnas.262787199 [Abstract] [Full Text] [PDF]  

Biophysics

Laura M. C. Barter, James R. Durrant, and David R. Klug

A quantitative structure-function relationship for the Photosystem II reaction center: Supermolecular behavior in natural photosynthesis
PNAS 2003 100: 946-951; published online before print January 21 2003, 10.1073/pnas.0136891100 [Abstract] [Full Text] [PDF]  

Bryan Bernat, Gabor Pal, Miao Sun, and Anthony A. Kossiakoff

Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization
PNAS 2003 100: 952-957; published online before print January 27 2003, 10.1073/pnas.0235023100 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

D. Bozovic and A. J. Hudspeth

Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog
PNAS 2003 100: 958-963; published online before print January 21 2003, 10.1073/pnas.0337433100 [Abstract] [Full Text] [PDF]  

Sven Geibel, Jack H. Kaplan, Ernst Bamberg, and Thomas Friedrich

Conformational dynamics of the Na⁺/K⁺-ATPase probed by voltage clamp fluorometry
PNAS 2003 100: 964-969; published online before print January 27 2003, 10.1073/pnas.0337336100 [Abstract] [Full Text] [PDF] [Supporting Figure] [Supporting Figure] [Supporting Figure] [Supporting Information]  

Onofrio Annunziata, Olutayo Ogun, and George B. Benedek

Observation of liquid-liquid phase separation for eye lens S-crystallin
PNAS 2003 100: 970-974; published online before print January 15 2003, 10.1073/pnas.242746499 [Abstract] [Full Text] [PDF]  

Cell Biology

Thomas Boehmer, Jost Enninga, Samuel Dales, Günter Blobel, and Hualin Zhong

Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex
PNAS 2003 100: 981-985; published online before print January 27 2003, 10.1073/pnas.252749899 [Abstract] [Full Text] [PDF]  

Katrina M. Comerford, Martin O. Leonard, Jorn Karhausen, Robyn Carey, Sean P. Colgan, and Cormac T. Taylor

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia
PNAS 2003 100: 986-991; published online before print January 27 2003, 10.1073/pnas.0337412100 [Abstract] [Full Text] [PDF]  

Mark A. Hall, David J. Curtis, Donald Metcalf, Andrew G. Elefanty, K. Sourris, Lorraine Robb, Joachim R. Göthert, Stephen M. Jane, and C. Glenn Begley

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S₁₂
PNAS 2003 100: 992-997; published online before print January 27 2003, 10.1073/pnas.0237324100 [Abstract] [Full Text] [PDF]  

Przemyslaw Blyszczuk, Jaroslaw Czyz, Gabriela Kania, Martin Wagner, Ursula Roll, Luc St-Onge, and Anna M. Wobus

Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
PNAS 2003 100: 998-1003; published online before print January 13 2003, 10.1073/pnas.0237371100 [Abstract] [Full Text] [PDF]  

Thaddeus S. Stappenbeck, Jason C. Mills, and Jeffrey I. Gordon

Molecular features of adult mouse small intestinal epithelial progenitors
PNAS 2003 100: 1004-1009; published online before print January 27 2003, 10.1073/pnas.242735899 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Deanna M. Green, Christie P. Johnson, Henry Hagan, and Anita H. Corbett

The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export
PNAS 2003 100: 1010-1015; published online before print January 16 2003, 10.1073/pnas.0336594100 [Abstract] [Full Text] [PDF] [Supporting Information]  

K. C. Leung, N. Doyle, M. Ballesteros, K. Sjogren, C. K. W. Watts, T. H. Low, G. M. Leong, R. J. M. Ross, and K. K. Y. Ho

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
PNAS 2003 100: 1016-1021; published online before print January 27 2003, 10.1073/pnas.0337600100 [Abstract] [Full Text] [PDF]  

Lihua He, Guy A. Perkins, Ann T. Poblenz, Jeffrey B. Harris, Michael Hung, Mark H. Ellisman, and Donald A. Fox

Bcl-x_L overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
PNAS 2003 100: 1022-1027; published online before print January 22 2003, 10.1073/pnas.0333594100 [Abstract] [Full Text] [PDF]  

I. Swameye, T. G. Müller, J. Timmer, O. Sandra, and U. Klingmüller

Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling
PNAS 2003 100: 1028-1033; published online before print January 27 2003, 10.1073/pnas.0237333100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Marcelo Páez-Pereda, Damiana Giacomini, Damian Refojo, Alberto Carbia Nagashima, Ursula Hopfner, Yvonne Grübler, Alberto Chervin, Victoria Goldberg, Rodolfo Goya, Shane T. Hentges, Malcolm J. Low, Florian Holsboer, Günter K. Stalla, and Eduardo Arzt

Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk
PNAS 2003 100: 1034-1039; published online before print January 27 2003, 10.1073/pnas.0237312100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Kathleen Gajewski, Jianbo Wang, Jeffery D. Molkentin, Elizabeth H. Chen, Eric N. Olson, and Robert A. Schulz

Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila
PNAS 2003 100: 1040-1045; published online before print January 21 2003, 10.1073/pnas.0337662100 [Abstract] [Full Text] [PDF]  

Ecology

Andrew Balmford, Kevin J. Gaston, Simon Blyth, Alex James, and Val Kapos

Global variation in terrestrial conservation costs, conservation benefits, and unmet conservation needs
PNAS 2003 100: 1046-1050; published online before print January 27 2003, 10.1073/pnas.0236945100 [Abstract] [Full Text] [PDF]  

Rita R. Colwell, Anwar Huq, M. Sirajul Islam, K. M. A. Aziz, M. Yunus, N. Huda Khan, A. Mahmud, R. Bradley Sack, G. B. Nair, J. Chakraborty, David A. Sack, and E. Russek-Cohen

Reduction of cholera in Bangladeshi villages by simple filtration
PNAS 2003 100: 1051-1055; published online before print January 14 2003, 10.1073/pnas.0237386100 [Abstract] [Full Text] [PDF]  

Evolution

Mark S. Springer, William J. Murphy, Eduardo Eizirik, and Stephen J. O'Brien

Placental mammal diversification and the Cretaceous-Tertiary boundary
PNAS 2003 100: 1056-1061; published online before print January 27 2003, 10.1073/pnas.0334222100 [Abstract] [Full Text] [PDF] [Supporting Information]  

F. Yang, E. Z. Alkalaeva, P. L. Perelman, A. T. Pardini, W. R. Harrison, P. C. M. O'Brien, B. Fu, A. S. Graphodatsky, M. A. Ferguson-Smith, and T. J. Robinson

Reciprocal chromosome painting among human, aardvark, and elephant (superorder Afrotheria) reveals the likely eutherian ancestral karyotype
PNAS 2003 100: 1062-1066; published online before print January 24 2003, 10.1073/pnas.0335540100 [Abstract] [Full Text] [PDF]  

Véronique Hannaert, Emma Saavedra, Francis Duffieux, Jean-Pierre Szikora, Daniel J. Rigden, Paul A. M. Michels, and Fred R. Opperdoes From the Cover: Plant-like traits associated with metabolism of Trypanosoma parasites PNAS 2003 100: 1067-1071; published online before print January 27 2003, 10.1073/pnas.0335769100 [Abstract] [Full Text] [PDF]   See Commentary on page 765

Tim F. Cooper, Daniel E. Rozen, and Richard E. Lenski

Parallel changes in gene expression after 20,000 generations of evolution in Escherichia coli
PNAS 2003 100: 1072-1077; published online before print January 21 2003, 10.1073/pnas.0334340100 [Abstract] [Full Text] [PDF]  

Neil D. Tsutsui, Andrew V. Suarez, and Richard K. Grosberg

Genetic diversity, asymmetrical aggression, and recognition in a widespread invasive species
PNAS 2003 100: 1078-1083; published online before print January 21 2003, 10.1073/pnas.0234412100 [Abstract] [Full Text] [PDF]  

Esther G. L. Koh, Kevin Lam, Alan Christoffels, Mark V. Erdmann, Sydney Brenner, and Byrappa Venkatesh

Hox gene clusters in the Indonesian coelacanth, Latimeria menadoensis
PNAS 2003 100: 1084-1088; published online before print January 23 2003, 10.1073/pnas.0237317100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Hudson Kern Reeve and David W. Pfennig

Genetic biases for showy males: Are some genetic systems especially conducive to sexual selection?
PNAS 2003 100: 1089-1094; published online before print January 22 2003, 10.1073/pnas.0337427100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Thomas Pfeiffer and Sebastian Bonhoeffer

An evolutionary scenario for the transition to undifferentiated multicellularity
PNAS 2003 100: 1095-1098; published online before print January 23 2003, 10.1073/pnas.0335420100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shah M. Faruque, David A. Sack, R. Bradley Sack, Rita R. Colwell, Yoshifumi Takeda, and G. Balakrish Nair Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Emergence and evolution of Vibrio cholerae O139 PNAS 2003 100: 1304-1309; published online before print January 21 2003, 10.1073/pnas.0337468100 [Abstract] [Full Text] [PDF]

Genetics

Kristi A. Egland, James J. Vincent, Robert Strausberg, Byungkook Lee, and Ira Pastan

Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins
PNAS 2003 100: 1099-1104; published online before print January 21 2003, 10.1073/pnas.0337425100 [Abstract] [Full Text] [PDF]  

Nathan B. Sutter, David Scalzo, Steven Fiering, Mark Groudine, and David I. K. Martin

Chromatin insulation by a transcriptional activator
PNAS 2003 100: 1105-1110; published online before print January 23 2003, 10.1073/pnas.242732999 [Abstract] [Full Text] [PDF]  

Xiao Hu, Michael Bulger, Julia N. Roach, Susan K. Eszterhas, Emmanuel Olivier, Eric E. Bouhassira, Mark T. Groudine, and Steven Fiering

Promoters of the murine embryonic -like globin genes Ey and h1 do not compete for interaction with the -globin locus control region
PNAS 2003 100: 1111-1115; published online before print January 13 2003, 10.1073/pnas.0337404100 [Abstract] [Full Text] [PDF]  

Jin Zhang, Jordi Asin-Cayuela, Jennifer Fish, Yuichi Michikawa, Massimiliano Bonafé, Fabiola Olivieri, Giuseppe Passarino, Giovanna De Benedictis, Claudio Franceschi, and Giuseppe Attardi

Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes
PNAS 2003 100: 1116-1121; published online before print January 21 2003, 10.1073/pnas.242719399 [Abstract] [Full Text] [PDF] [Supporting Information]  
See Commentary on page 2174

He Yang, Hadar Haddad, Christopher Tomas, Keith Alsaker, and E. Terry Papoutsakis

A segmental nearest neighbor normalization and gene identification method gives superior results for DNA-array analysis
PNAS 2003 100: 1122-1127; published online before print January 15 2003, 10.1073/pnas.0237337100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Alexander W. Rives and Timothy Galitski

Modular organization of cellular networks
PNAS 2003 100: 1128-1133; published online before print January 21 2003, 10.1073/pnas.0237338100 [Abstract] [Full Text] [PDF]  

Vladimir V. Feschenko, Luis A. Rajman, and Susan T. Lovett

Stabilization of perfect and imperfect tandem repeats by single-strand DNA exonucleases
PNAS 2003 100: 1134-1139; published online before print January 21 2003, 10.1073/pnas.0233122100 [Abstract] [Full Text] [PDF]  

Roderic Guigó, Emmanouil T. Dermitzakis, Pankaj Agarwal, Chris P. Ponting, Genís Parra, Alexandre Reymond, Josep F. Abril, Evan Keibler, Robert Lyle, Catherine Ucla, Stylianos E. Antonarakis, and Michael R. Brent

Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes
PNAS 2003 100: 1140-1145; published online before print January 27 2003, 10.1073/pnas.0337561100 [Abstract] [Full Text] [PDF]  

Tamio Suzuki, Naoki Oiso, Rashi Gautam, Edward K. Novak, Jean-Jacques Panthier, P. G. Suprabha, Thomas Vida, Richard T. Swank, and Richard A. Spritz

The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation
PNAS 2003 100: 1146-1150; published online before print January 21 2003, 10.1073/pnas.0237292100 [Abstract] [Full Text] [PDF]  

Melissa A. Fleming, John D. Potter, Christina J. Ramirez, Gary K. Ostrander, and Elaine A. Ostrander

Understanding missense mutations in the BRCA1 gene: An evolutionary approach
PNAS 2003 100: 1151-1156; published online before print January 16 2003, 10.1073/pnas.0237285100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Joo-Yeon Yoo and Stephen Desiderio

Innate and acquired immunity intersect in a global view of the acute-phase response
PNAS 2003 100: 1157-1162; published online before print January 22 2003, 10.1073/pnas.0336385100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Steven R. Leong, Jean C. C. Chang, Randal Ong, Glenn Dawes, Willem P. C. Stemmer, and Juha Punnonen

Optimized expression and specific activity of IL-12 by directed molecular evolution
PNAS 2003 100: 1163-1168; published online before print January 15 2003, 10.1073/pnas.0237327100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cu Nguyen, Jia-Ling Teo, Akihisa Matsuda, Masakatsu Eguchi, Emil Y. Chi, William R. Henderson, Jr., and Michael Kahn

Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma
PNAS 2003 100: 1169-1173; published online before print January 24 2003, 10.1073/pnas.0437889100 [Abstract] [Full Text] [PDF]  

Nicodemus Tedla, Christianne Bandeira-Melo, Paolo Tassinari, David E. Sloane, Mary Samplaski, David Cosman, Luis Borges, Peter F. Weller, and Jonathan P. Arm

Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7
PNAS 2003 100: 1174-1179; published online before print January 14 2003, 10.1073/pnas.0337567100 [Abstract] [Full Text] [PDF]  

J. Michálek, R. H. Collins, H. P. Durrani, P. Václavková, L. E. Ruff, D. C. Douek, and E. S. Vitetta

Definitive separation of graft-versus-leukemia- and graft-versus-host-specific CD4⁺ T cells by virtue of their receptor loci sequences
PNAS 2003 100: 1180-1184; published online before print January 16 2003, 10.1073/pnas.0337543100 [Abstract] [Full Text] [PDF]  

Christina T. Moses, Kristen M. Thorstenson, Stephen C. Jameson, and Alexander Khoruts

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells
PNAS 2003 100: 1185-1190; published online before print January 13 2003, 10.1073/pnas.0334572100 [Abstract] [Full Text] [PDF]  

Philippe Moreau, Gaël Mouillot, Philippe Rousseau, Céline Marcou, Jean Dausset, and Edgardo D. Carosella

HLA-G gene repression is reversed by demethylation
PNAS 2003 100: 1191-1196; published online before print January 27 2003, 10.1073/pnas.0337539100 [Abstract] [Full Text] [PDF]  

Yifan Zhan, Jared F. Purton, Dale I. Godfrey, Timothy J. Cole, William R. Heath, and Andrew M. Lew

Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation
PNAS 2003 100: 1197-1202; published online before print January 21 2003, 10.1073/pnas.0237316100 [Abstract] [Full Text] [PDF]  

Shinyop Kim, Ross N. A. La Motte-Mohs, Dorothea Rudolph, Juan Carlos Zúñiga-Pflücker, and Tak W. Mak

The role of nuclear factor-B essential modulator (NEMO) in B cell development and survival
PNAS 2003 100: 1203-1208; published online before print January 21 2003, 10.1073/pnas.0337707100 [Abstract] [Full Text] [PDF]  

Yoshiko Akamatsu, Robert Monroe, Darryll D. Dudley, Sheryl K. Elkin, Frank Gärtner, Sadiqur R. Talukder, Yousuke Takahama, Frederick W. Alt, Craig H. Bassing, and Marjorie A. Oettinger

Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
PNAS 2003 100: 1209-1214; published online before print January 16 2003, 10.1073/pnas.0237043100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Medical Sciences

Iqbal Hamza, Joseph Prohaska, and Jonathan D. Gitlin

Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase
PNAS 2003 100: 1215-1220; published online before print January 21 2003, 10.1073/pnas.0336230100 [Abstract] [Full Text] [PDF]  

Karuppiah Kannan, Norman E. Sharpless, Jin Xu, Ronan C. O'Hagan, Marcus Bosenberg, and Lynda Chin

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model
PNAS 2003 100: 1221-1225; published online before print January 21 2003, 10.1073/pnas.0336397100 [Abstract] [Full Text] [PDF]  

Brian N. Finck, Xianlin Han, Michael Courtois, Franck Aimond, Jeanne M. Nerbonne, Attila Kovacs, Richard W. Gross, and Daniel P. Kelly

A critical role for PPAR-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
PNAS 2003 100: 1226-1231; published online before print January 27 2003, 10.1073/pnas.0336724100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Purnima Dubey, Helen Su, Nona Adonai, Shouying Du, Antonio Rosato, Jonathan Braun, Sanjiv S. Gambhir, and Owen N. Witte

Quantitative imaging of the T cell antitumor response by positron-emission tomography
PNAS 2003 100: 1232-1237; published online before print January 23 2003, 10.1073/pnas.0337418100 [Abstract] [Full Text] [PDF]  

Rainer Spanbroek, Rolf Gräbner, Katharina Lötzer, Markus Hildner, Anja Urbach, Katharina Rühling, Michael P. W. Moos, Brigitte Kaiser, Tina U. Cohnert, Thorsten Wahlers, Arthur Zieske, Gabriele Plenz, Horst Robenek, Peter Salbach, Hartmut Kühn, Olof Rådmark, Bengt Samuelsson, and Andreas J. R. Habenicht

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
PNAS 2003 100: 1238-1243; published online before print January 27 2003, 10.1073/pnas.242716099 [Abstract] [Full Text] [PDF] [Supporting Information]  

Donald Metcalf, Ladina Di Rago, and Sandra Mifsud

Crowding-dependent production of colony-stimulating factors by cultured syngeneic or allogeneic hematopoietic cells
PNAS 2003 100: 1244-1249; published online before print January 27 2003, 10.1073/pnas.252756999 [Abstract] [Full Text] [PDF]  

Markus Letsch, Andrew V. Schally, Rebeca Busto, Ana M. Bajo, and Jozsef L. Varga

Growth hormone-releasing hormone (GHRH) antagonists inhibit the proliferation of androgen-dependent and -independent prostate cancers
PNAS 2003 100: 1250-1255; published online before print January 21 2003, 10.1073/pnas.0337496100 [Abstract] [Full Text] [PDF]  

Zhihua Han, Quynh A. Truong, Shirley Park, and Jan L. Breslow

Two Hsp70 family members expressed in atherosclerotic lesions
PNAS 2003 100: 1256-1261; published online before print January 27 2003, 10.1073/pnas.252764399 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Emily L. Willner, Bryan Tow, Kimberly K. Buhman, Martha Wilson, David A. Sanan, Lawrence L. Rudel, and Robert V. Farese, Jr.

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
PNAS 2003 100: 1262-1267; published online before print January 21 2003, 10.1073/pnas.0336398100 [Abstract] [Full Text] [PDF]  

Ajay Chawla, Chih-Hao Lee, Yaacov Barak, Weimin He, John Rosenfeld, Debbie Liao, Jungyeob Han, Heonjoong Kang, and Ronald M. Evans

PPAR is a very low-density lipoprotein sensor in macrophages
PNAS 2003 100: 1268-1273; published online before print January 22 2003, 10.1073/pnas.0337331100 [Abstract] [Full Text] [PDF]  

Megumi Honjo, Kayo Nakamura, Kenji Yamashiro, Junichi Kiryu, Hidenobu Tanihara, Leslie M. McEvoy, Yoshihito Honda, Eugene C. Butcher, Tomoh Masaki, and Tatsuya Sawamura

Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation
PNAS 2003 100: 1274-1279; published online before print January 21 2003, 10.1073/pnas.0337528100 [Abstract] [Full Text] [PDF]  

Microbiology

Shah M. Faruque, M. Kamruzzaman, Asadulghani, David A. Sack, John J. Mekalanos, and G. Balakrish Nair

CTX-independent production of the RS1 satellite phage by Vibrio cholerae
PNAS 2003 100: 1280-1285; published online before print January 14 2003, 10.1073/pnas.0237385100 [Abstract] [Full Text] [PDF]  

Qing Xu, Michelle Dziejman, and John J. Mekalanos

Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitro
PNAS 2003 100: 1286-1291; published online before print January 27 2003, 10.1073/pnas.0337479100 [Abstract] [Full Text] [PDF] [Supporting Information] [Online Correction to Supporting Table 5]  

Anne Mueller, Jani O'Rourke, Jan Grimm, Karen Guillemin, Michael F. Dixon, Adrian Lee, and Stanley Falkow

Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma
PNAS 2003 100: 1292-1297; published online before print January 27 2003, 10.1073/pnas.242741699 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Neeltje A. Kootstra, Carsten Münk, Nina Tonnu, Nathaniel R. Landau, and Inder M. Verma

Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells
PNAS 2003 100: 1298-1303; published online before print January 23 2003, 10.1073/pnas.0337541100 [Abstract] [Full Text] [PDF]  

Shah M. Faruque, David A. Sack, R. Bradley Sack, Rita R. Colwell, Yoshifumi Takeda, and G. Balakrish Nair Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Emergence and evolution of Vibrio cholerae O139 PNAS 2003 100: 1304-1309; published online before print January 21 2003, 10.1073/pnas.0337468100 [Abstract] [Full Text] [PDF]

Susan L. Uprichard, Stefan F. Wieland, Alana Althage, and Francis V. Chisari

Transcriptional and posttranscriptional control of hepatitis B virus gene expression
PNAS 2003 100: 1310-1315; published online before print January 27 2003, 10.1073/pnas.252773599 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Holger Brüggemann, Sebastian Bäumer, Wolfgang Florian Fricke, Arnim Wiezer, Heiko Liesegang, Iwona Decker, Christina Herzberg, Rosa Martínez-Arias, Rainer Merkl, Anke Henne, and Gerhard Gottschalk

The genome sequence of Clostridium tetani, the causative agent of tetanus disease
PNAS 2003 100: 1316-1321; published online before print January 27 2003, 10.1073/pnas.0335853100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Akinori Nishi, Feng Liu, Seiichiro Matsuyama, Miho Hamada, Hideho Higashi, Angus C. Nairn, and Paul Greengard

Metabotropic mGlu5 receptors regulate adenosine A_2A receptor signaling
PNAS 2003 100: 1322-1327; published online before print January 21 2003, 10.1073/pnas.0237126100 [Abstract] [Full Text] [PDF]  

Benno Roozendaal, Qyana K. Griffith, Jason Buranday, Dominique J.-F. de Quervain, and James L. McGaugh

The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala
PNAS 2003 100: 1328-1333; published online before print January 21 2003, 10.1073/pnas.0337480100 [Abstract] [Full Text] [PDF]  

Akira Yoshii, Morgan H. Sheng, and Martha Constantine-Paton

Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons
PNAS 2003 100: 1334-1339; published online before print January 27 2003, 10.1073/pnas.0335785100