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EDITORIAL

Nicholas R. Cozzarelli

PNAS policy on publication of sensitive material in the life sciences
PNAS 2003 100: 1463; published online before print February 15 2003, 10.1073/pnas.0630514100 [Extract] [Full Text] [PDF]  

Journal Editors and Authors Group

Uncensored exchange of scientific results
PNAS 2003 100: 1464; published online before print February 15 2003, 10.1073/pnas.0630491100 [Extract] [Full Text] [PDF] [Full List of Author Names]  

COMMENTARIES

Fabrice Roegiers

Insights into mRNA transport in neurons
PNAS 2003 100: 1465-1466; published online before print February 10 2003, 10.1073/pnas.0630376100 [Extract] [Full Text] [PDF]  
See companion article on page 2100

James H. Brown and James F. Gillooly

Ecological food webs: High-quality data facilitate theoretical unification
PNAS 2003 100: 1467-1468; published online before print February 10 2003, 10.1073/pnas.0630310100 [Extract] [Full Text] [PDF]  
See companion article on page 1781

H. C. Muller-Landau

Seeds of understanding of plant diversity
PNAS 2003 100: 1469-1471; published online before print February 10 2003, 10.1073/pnas.0438004100 [Extract] [Full Text] [PDF]  
See companion article on page 1787

Donald E. Ingber

Mechanosensation through integrins: Cells act locally but think globally
PNAS 2003 100: 1472-1474; published online before print February 10 2003, 10.1073/pnas.0530201100 [Extract] [Full Text] [PDF]  
See companion article on page 1484

PERSPECTIVES

Eric H. Davidson, David R. McClay, and Leroy Hood

Regulatory gene networks and the properties of the developmental process
PNAS 2003 100: 1475-1480; published online before print February 10 2003, 10.1073/pnas.0437746100 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

G. I. Barenblatt

Transfer of a passive additive in a turbulent boundary layer at very large Reynolds numbers
PNAS 2003 100: 1481-1483; published online before print February 10 2003, 10.1073/pnas.0337426100 [Abstract] [Full Text] [PDF]  

Applied Physical Sciences

Chemistry

Paul Wentworth, Jr., Anita D. Wentworth, Xueyong Zhu, Ian A. Wilson, Kim D. Janda, Albert Eschenmoser, and Richard A. Lerner

Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens
PNAS 2003 100: 1490-1493; published online before print February 7 2003, 10.1073/pnas.0437831100 [Abstract] [Full Text] [PDF]  

Antonio S. Torralba, Kristine Yu, Peidong Shen, Peter J. Oefner, and John Ross

Experimental test of a method for determining causal connectivities of species in reactions
PNAS 2003 100: 1494-1498; published online before print February 7 2003, 10.1073/pnas.262790699 [Abstract] [Full Text] [PDF]  

Engineering

Chihchen Chen, Danny Hirdes, and Albert Folch

Gray-scale photolithography using microfluidic photomasks
PNAS 2003 100: 1499-1504; published online before print February 6 2003, 10.1073/pnas.0435755100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geophysics

Renyi Zhang, Xuexi Tie, and Donald W. Bond

Impacts of anthropogenic and natural NO_x sources over the U.S. on tropospheric chemistry
PNAS 2003 100: 1505-1509; published online before print January 27 2003, 10.1073/pnas.252763799 [Abstract] [Full Text] [PDF]  

Mathematics

Michael K.-H. Kiessling and Thomas Neukirch

Negative specific heat of a magnetically self-confined plasma torus
PNAS 2003 100: 1510-1514; published online before print February 7 2003, 10.1073/pnas.252779099 [Abstract] [Full Text] [PDF]  

Physics

Vassiliy Lubchenko and Peter G. Wolynes

The origin of the boson peak and thermal conductivity plateau in low-temperature glasses
PNAS 2003 100: 1515-1518; published online before print February 10 2003, 10.1073/pnas.252786999 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Psychology

Lila Davachi, Jason P. Mitchell, and Anthony D. Wagner

Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories
PNAS 2003 100: 2157-2162; published online before print February 10 2003, 10.1073/pnas.0337195100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

Yves Carrière, Christa Ellers-Kirk, Mark Sisterson, Larry Antilla, Mike Whitlow, Timothy J. Dennehy, and Bruce E. Tabashnik

Long-term regional suppression of pink bollworm by Bacillus thuringiensis cotton
PNAS 2003 100: 1519-1523; published online before print February 5 2003, 10.1073/pnas.0436708100 [Abstract] [Full Text] [PDF]  

Anthropology

Applied Biological Sciences

Matthew D. Disney, Constantine G. Haidaris, and Douglas H. Turner

Uptake and antifungal activity of oligonucleotides in Candida albicans
PNAS 2003 100: 1530-1534; published online before print January 27 2003, 10.1073/pnas.0337462100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biochemistry

Paul Wentworth, Jr., Anita D. Wentworth, Xueyong Zhu, Ian A. Wilson, Kim D. Janda, Albert Eschenmoser, and Richard A. Lerner

Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens
PNAS 2003 100: 1490-1493; published online before print February 7 2003, 10.1073/pnas.0437831100 [Abstract] [Full Text] [PDF]  

Assen Marintchev, Victoria G. Kolupaeva, Tatyana V. Pestova, and Gerhard Wagner

Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners
PNAS 2003 100: 1535-1540; published online before print February 4 2003, 10.1073/pnas.0437845100 [Abstract] [Full Text] [PDF]  

Bertolt Gust, Greg L. Challis, Kay Fowler, Tobias Kieser, and Keith F. Chater

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin
PNAS 2003 100: 1541-1546; published online before print January 31 2003, 10.1073/pnas.0337542100 [Abstract] [Full Text] [PDF]  

David E. Cane and Rory M. Watt

Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis
PNAS 2003 100: 1547-1551; published online before print January 29 2003, 10.1073/pnas.0337625100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Annette Cronin, Sherry Mowbray, Heike Dürk, Shirli Homburg, Ingrid Fleming, Beate Fisslthaler, Franz Oesch, and Michael Arand

The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
PNAS 2003 100: 1552-1557; published online before print February 6 2003, 10.1073/pnas.0437829100 [Abstract] [Full Text] [PDF]  

John W. Newman, Christophe Morisseau, Todd R. Harris, and Bruce D. Hammock

The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
PNAS 2003 100: 1558-1563; published online before print February 6 2003, 10.1073/pnas.0437724100 [Abstract] [Full Text] [PDF]  

Antoine Kichler, Christian Leborgne, Josefine März, Olivier Danos, and Burkhard Bechinger

Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells
PNAS 2003 100: 1564-1568; published online before print January 31 2003, 10.1073/pnas.0337677100 [Abstract] [Full Text] [PDF]  

Patrizia Alberti and Jean-Louis Mergny

DNA duplex-quadruplex exchange as the basis for a nanomolecular machine
PNAS 2003 100: 1569-1573; published online before print February 6 2003, 10.1073/pnas.0335459100 [Abstract] [Full Text] [PDF]  

Prashanth Rangan, Benoît Masquida, Eric Westhof, and Sarah A. Woodson

Assembly of core helices and rapid tertiary folding of a small bacterial group I ribozyme
PNAS 2003 100: 1574-1579; published online before print February 6 2003, 10.1073/pnas.0337743100 [Abstract] [Full Text] [PDF] [Supporting Information]  

László G. Puskás, Klára Kitajka, Csaba Nyakas, Gwendolyn Barcelo-Coblijn, and Tibor Farkas

Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus
PNAS 2003 100: 1580-1585; published online before print February 3 2003, 10.1073/pnas.0337683100 [Abstract] [Full Text] [PDF]  

Felix Rohdich, Ferdinand Zepeck, Petra Adam, Stefan Hecht, Johannes Kaiser, Ralf Laupitz, Tobias Gräwert, Sabine Amslinger, Wolfgang Eisenreich, Adelbert Bacher, and Duilio Arigoni

The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: Studies on the mechanisms of the reactions catalyzed by IspG and IspH protein
PNAS 2003 100: 1586-1591; published online before print February 5 2003, 10.1073/pnas.0337742100 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

Francesco Trapasso, Agnieszka Krakowiak, Rossano Cesari, Jeffrey Arkles, Sai Yendamuri, Hideshi Ishii, Andrea Vecchione, Tamotsu Kuroki, Pawel Bieganowski, Helen C. Pace, Kay Huebner, Carlo M. Croce, and Charles Brenner

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding
PNAS 2003 100: 1592-1597; published online before print February 6 2003, 10.1073/pnas.0437915100 [Abstract] [Full Text] [PDF]  

Elizaveta Kovrigina, Donna Wesolowski, and Sidney Altman

Coordinate inhibition of expression of several genes for protein subunits of human nuclear RNase P
PNAS 2003 100: 1598-1602; published online before print January 27 2003, 10.1073/pnas.0337661100 [Abstract] [Full Text] [PDF]  

Michelle R. Arkin, Mike Randal, Warren L. DeLano, Jennifer Hyde, Tinh N. Luong, Johan D. Oslob, Darren R. Raphael, Lisa Taylor, Jun Wang, Robert S. McDowell, James A. Wells, and Andrew C. Braisted

Binding of small molecules to an adaptive protein-protein interface
PNAS 2003 100: 1603-1608; published online before print February 11 2003, 10.1073/pnas.252756299 [Abstract] [Full Text] [PDF] [Supporting Information]  

Xuejun Huang Parsons, Sandra N. Garcia, Lorraine Pillus, and James T. Kadonaga

Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex
PNAS 2003 100: 1609-1614; published online before print February 5 2003, 10.1073/pnas.0434064100 [Abstract] [Full Text] [PDF]  

Lindsey Reynolds, Christopher Ullman, Michael Moore, Mark Isalan, Michelle J. West, Paul Clapham, Aaron Klug, and Yen Choo

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors
PNAS 2003 100: 1615-1620; published online before print February 6 2003, 10.1073/pnas.252770699 [Abstract] [Full Text] [PDF]  

Monika Papworth, Michael Moore, Mark Isalan, Michal Minczuk, Yen Choo, and Aaron Klug

Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors
PNAS 2003 100: 1621-1626; published online before print February 6 2003, 10.1073/pnas.252773399 [Abstract] [Full Text] [PDF]  

Hewang Li, Ronald Adamik, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan

Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)
PNAS 2003 100: 1627-1632; published online before print February 5 2003, 10.1073/pnas.0337678100 [Abstract] [Full Text] [PDF]  

Vladimir P. Bermudez, Laura A. Lindsey-Boltz, Anthony J. Cesare, Yoshimasa Maniwa, Jack D. Griffith, Jerard Hurwitz, and Aziz Sancar

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
PNAS 2003 100: 1633-1638; published online before print February 10 2003, 10.1073/pnas.0437927100 [Abstract] [Full Text] [PDF]  

Paolo Fruscoloni, Michela Zamboni, M. Irene Baldi, and Glauco P. Tocchini-Valentini

Exonucleolytic degradation of double-stranded RNA by an activity in Xenopus laevis germinal vesicles
PNAS 2003 100: 1639-1644; published online before print February 10 2003, 10.1073/pnas.252777499 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mark A. McCoy, Jennifer J. Gesell, Mary M. Senior, and Daniel F. Wyss

Flexible lid to the p53-binding domain of human Mdm2: Implications for p53 regulation
PNAS 2003 100: 1645-1648; published online before print January 27 2003, 10.1073/pnas.0334477100 [Abstract] [Full Text] [PDF]  

Sudarshan Rajagopal and Keith Moffat

Crystal structure of a photoactive yellow protein from a sensor histidine kinase: Conformational variability and signal transduction
PNAS 2003 100: 1649-1654; published online before print January 31 2003, 10.1073/pnas.0336353100 [Abstract] [Full Text] [PDF]  

P. J. Rothwell, S. Berger, O. Kensch, S. Felekyan, M. Antonik, B. M. Wöhrl, T. Restle, R. S. Goody, and C. A. M. Seidel

Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes
PNAS 2003 100: 1655-1660; published online before print February 10 2003, 10.1073/pnas.0434003100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Anton Meinhart, Juan C. Alonso, Norbert Sträter, and Wolfram Saenger

Crystal structure of the plasmid maintenance system /: Functional mechanism of toxin and inactivation by ₂₂ complex formation
PNAS 2003 100: 1661-1666; published online before print February 5 2003, 10.1073/pnas.0434325100 [Abstract] [Full Text] [PDF]  

Oded Lewinson, Julia Adler, Gerrit J. Poelarends, Piotr Mazurkiewicz, Arnold J. M. Driessen, and Eitan Bibi

The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions
PNAS 2003 100: 1667-1672; published online before print February 10 2003, 10.1073/pnas.0435544100 [Abstract] [Full Text] [PDF]  

Biophysics

Satwik Kamtekar, W. Dexter Kennedy, Jimin Wang, Constantinos Stathopoulos, Dieter Söll, and Thomas A. Steitz

The structural basis of cysteine aminoacylation of tRNA^Pro by prolyl-tRNA synthetases
PNAS 2003 100: 1673-1678; published online before print February 10 2003, 10.1073/pnas.0437911100 [Abstract] [Full Text] [PDF]  

Corey Hardin, Michael P. Eastwood, Michael C. Prentiss, Zadia Luthey-Schulten, and Peter G. Wolynes

Associative memory Hamiltonians for structure prediction without homology: / proteins
PNAS 2003 100: 1679-1684; published online before print January 28 2003, 10.1073/pnas.252753899 [Abstract] [Full Text] [PDF]  

R. J. Walsh, S. Matsuzaki, T. Reinot, J. M. Hayes, K. R. Kalli, L. C. Hartmann, and G. J. Small

Single-cell nonphotochemical hole burning of ovarian surface epithelial carcinoma and normal cells
PNAS 2003 100: 1685-1689; published online before print February 6 2003, 10.1073/pnas.0437668100 [Abstract] [Full Text] [PDF]  

Simon Scheuring, Jérôme Seguin, Sergio Marco, Daniel Lévy, Bruno Robert, and Jean-Louis Rigaud

Nanodissection and high-resolution imaging of the Rhodopseudomonas viridis photosynthetic core complex in native membranes by AFM
PNAS 2003 100: 1690-1693; published online before print February 6 2003, 10.1073/pnas.0437992100 [Abstract] [Full Text] [PDF]  

Claudia Danilowicz, Vincent W. Coljee, Cedric Bouzigues, David K. Lubensky, David R. Nelson, and Mara Prentiss

DNA unzipped under a constant force exhibits multiple metastable intermediates
PNAS 2003 100: 1694-1699; published online before print February 6 2003, 10.1073/pnas.262789199 [Abstract] [Full Text] [PDF]  

Andreas Kohl, H. Kaspar Binz, Patrik Forrer, Michael T. Stumpp, Andreas Plückthun, and Markus G. Grütter

Designed to be stable: Crystal structure of a consensus ankyrin repeat protein
PNAS 2003 100: 1700-1705; published online before print February 3 2003, 10.1073/pnas.0337680100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Marian Nanias, Maurizio Chinchio, Jarosaw Pillardy, Daniel R. Ripoll, and Harold A. Scheraga

Packing helices in proteins by global optimization of a potential energy function
PNAS 2003 100: 1706-1710; published online before print February 5 2003, 10.1073/pnas.252760199 [Abstract] [Full Text] [PDF]  

Cell Biology

Michael P. Czubryt, John McAnally, Glenn I. Fishman, and Eric N. Olson

Regulation of peroxisome proliferator-activated receptor coactivator 1 (PGC-1) and mitochondrial function by MEF2 and HDAC5
PNAS 2003 100: 1711-1716; published online before print February 10 2003, 10.1073/pnas.0337639100 [Abstract] [Full Text] [PDF]  

Attila Becskei and Iain W. Mattaj

The strategy for coupling the RanGTP gradient to nuclear protein export
PNAS 2003 100: 1717-1722; published online before print January 31 2003, 10.1073/pnas.252766999 [Abstract] [Full Text] [PDF] [Supporting Text]  

Scott H. Soderling, Lorene K. Langeberg, Jacquelyn A. Soderling, Stephen M. Davee, Richard Simerly, Jacob Raber, and John D. Scott

Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
PNAS 2003 100: 1723-1728; published online before print February 10 2003, 10.1073/pnas.0438033100 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

Meir H. Scheinfeld, Shuji Matsuda, and Luciano D'Adamio

JNK-interacting protein-1 promotes transcription of A protein precursor but not A precursor-like proteins, mechanistically different than Fe65
PNAS 2003 100: 1729-1734; published online before print January 31 2003, 10.1073/pnas.0437908100 [Abstract] [Full Text] [PDF]  

Asoke Mal and Marian L. Harter

MyoD is functionally linked to the silencing of a muscle-specific regulatory gene prior to skeletal myogenesis
PNAS 2003 100: 1735-1739; published online before print February 10 2003, 10.1073/pnas.0437843100 [Abstract] [Full Text] [PDF]  

Seungkirl Ahn, Christopher D. Nelson, Tiffany Runyan Garrison, William E. Miller, and Robert J. Lefkowitz

Desensitization, internalization, and signaling functions of -arrestins demonstrated by RNA interference
PNAS 2003 100: 1740-1744; published online before print February 11 2003, 10.1073/pnas.262789099 [Abstract] [Full Text] [PDF]  

Bin Zheng, Christopher P. Berrie, Daniela Corda, and Marilyn G. Farquhar

GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors
PNAS 2003 100: 1745-1750; published online before print February 7 2003, 10.1073/pnas.0337605100 [Abstract] [Full Text] [PDF]  

Dilprit Bagga, Ling Wang, Robin Farias-Eisner, John A. Glaspy, and Srinivasa T. Reddy

Differential effects of prostaglandin derived from -6 and -3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion
PNAS 2003 100: 1751-1756; published online before print February 10 2003, 10.1073/pnas.0334211100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Elaine E. Storm, John L. R. Rubenstein, and Gail R. Martin

Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain
PNAS 2003 100: 1757-1762; published online before print February 6 2003, 10.1073/pnas.0337736100 [Abstract] [Full Text] [PDF]  

Julien Vermot, Karen Niederreither, Jean-Marie Garnier, Pierre Chambon, and Pascal Dollé

Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice
PNAS 2003 100: 1763-1768; published online before print January 31 2003, 10.1073/pnas.0437920100 [Abstract] [Full Text] [PDF]  

Alexander M. Schreiber and Donald D. Brown

Tadpole skin dies autonomously in response to thyroid hormone at metamorphosis
PNAS 2003 100: 1769-1774; published online before print January 30 2003, 10.1073/pnas.252774999 [Abstract] [Full Text] [PDF]  

Christopher C. Oakes, Dominic J. Smiraglia, Christoph Plass, Jacquetta M. Trasler, and Bernard Robaire

Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats
PNAS 2003 100: 1775-1780; published online before print February 6 2003, 10.1073/pnas.0437971100 [Abstract] [Full Text] [PDF]  

Ecology

María Uriarte and Hudson Kern Reeve From the Cover: Matchmaking and species marriage: A game-theory model of community assembly PNAS 2003 100: 1787-1792; published online before print February 7 2003, 10.1073/pnas.0337167100 [Abstract] [Full Text] [PDF]   See Commentary on page 1469

Evolution

Alberto G. Sáez, Andrey Tatarenkov, Eladio Barrio, Nelsson H. Becerra, and Francisco J. Ayala

Patterns of DNA sequence polymorphism at Sod vicinities in Drosophila melanogaster: Unraveling the footprint of a recent selective sweep
PNAS 2003 100: 1793-1798; published online before print February 10 2003, 10.1073/pnas.242746799 [Abstract] [Full Text] [PDF]  

Gro V. Amdam, Kari Norberg, Arne Hagen, and Stig W. Omholt

Social exploitation of vitellogenin
PNAS 2003 100: 1799-1802; published online before print February 3 2003, 10.1073/pnas.0333979100 [Abstract] [Full Text] [PDF]  

Kerry M. Oliver, Jacob A. Russell, Nancy A. Moran, and Martha S. Hunter

Facultative bacterial symbionts in aphids confer resistance to parasitic wasps
PNAS 2003 100: 1803-1807; published online before print January 31 2003, 10.1073/pnas.0335320100 [Abstract] [Full Text] [PDF]  

Patricia J. Wittkopp, Barry L. Williams, Jayne E. Selegue, and Sean B. Carroll

Drosophila pigmentation evolution: Divergent genotypes underlying convergent phenotypes
PNAS 2003 100: 1808-1813; published online before print February 6 2003, 10.1073/pnas.0336368100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Marco Di Fruscio, Sylvia Styhler, Eva Wikholm, Marie-Chloé Boulanger, Paul Lasko, and Stéphane Richard

kep1 interacts genetically with dredd/Caspase-8, and kep1 mutants alter the balance of dredd isoforms
PNAS 2003 100: 1814-1819; published online before print January 31 2003, 10.1073/pnas.0236048100 [Abstract] [Full Text] [PDF]  

Huck Hui Ng, David N. Ciccone, Katrina B. Morshead, Marjorie A. Oettinger, and Kevin Struhl

Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation
PNAS 2003 100: 1820-1825; published online before print February 6 2003, 10.1073/pnas.0437846100 [Abstract] [Full Text] [PDF]  

Andrew S. McCallion, Erine Stames, Ronald A. Conlon, and Aravinda Chakravarti

Phenotype variation in two-locus mouse models of Hirschsprung disease: Tissue-specific interaction between Ret and Ednrb
PNAS 2003 100: 1826-1831; published online before print February 6 2003, 10.1073/pnas.0337540100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Eline T. Luning Prak, Allen W. Dodson, Evan A. Farkash, and Haig H. Kazazian, Jr.

Tracking an embryonic L1 retrotransposition event
PNAS 2003 100: 1832-1837; published online before print February 4 2003, 10.1073/pnas.0337627100 [Abstract] [Full Text] [PDF]  

Elizabeth Mambo, Xiangqun Gao, Yoram Cohen, Zhongmin Guo, Paul Talalay, and David Sidransky

Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations
PNAS 2003 100: 1838-1843; published online before print February 10 2003, 10.1073/pnas.0437910100 [Abstract] [Full Text] [PDF]  

Gustavo Tiscornia, Oded Singer, Masahito Ikawa, and Inder M. Verma

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
PNAS 2003 100: 1844-1848; published online before print January 27 2003, 10.1073/pnas.0437912100 [Abstract] [Full Text] [PDF]  

Immunology

Aleksandar K. Stanic, A. Dharshan De Silva, Jang-June Park, Venkataraman Sriram, Shinichi Ichikawa, Yoshio Hirabyashi, Kyoko Hayakawa, Luc Van Kaer, Randy R. Brutkiewicz, and Sebastian Joyce

Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by -D-glucosylceramide synthase deficiency
PNAS 2003 100: 1849-1854; published online before print February 7 2003, 10.1073/pnas.0430327100 [Abstract] [Full Text] [PDF]  

Natalia L. Komarova, Eleanor Barnes, Paul Klenerman, and Dominik Wodarz

Boosting immunity by antiviral drug therapy: A simple relationship among timing, efficacy, and success
PNAS 2003 100: 1855-1860; published online before print February 6 2003, 10.1073/pnas.0337483100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Marianne M. Martinic, Thomas Rülicke, Alana Althage, Bernhard Odermatt, Matthias Höchli, Alain Lamarre, Tilman Dumrese, Daniel E. Speiser, Diego Kyburz, Hans Hengartner, and Rolf M. Zinkernagel

Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC
PNAS 2003 100: 1861-1866; published online before print February 6 2003, 10.1073/pnas.252641399 [Abstract] [Full Text] [PDF] [Supporting Table]  

Rosetta Pedotti, Jason J. DeVoss, Sawsan Youssef, Dennis Mitchell, Jochen Wedemeyer, Rami Madanat, Hideki Garren, Paulo Fontoura, Mindy Tsai, Stephen J. Galli, Raymond A. Sobel, and Lawrence Steinman

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination
PNAS 2003 100: 1867-1872; published online before print February 7 2003, 10.1073/pnas.252777399 [Abstract] [Full Text] [PDF]  

Thomas Vorup-Jensen, Christian Ostermeier, Motomu Shimaoka, Ulrich Hommel, and Timothy A. Springer

Structure and allosteric regulation of the X2 integrin I domain
PNAS 2003 100: 1873-1878; published online before print January 28 2003, 10.1073/pnas.0237387100 [Abstract] [Full Text] [PDF]  

Thomas Welte, Samuel S. M. Zhang, Tian Wang, Zhiyuan Zhang, David G. T. Hesslein, Zhinan Yin, Arihiro Kano, Yoshiki Iwamoto, En Li, Joseph E. Craft, Alfred L. M. Bothwell, Erol Fikrig, Pandelakis A. Koni, Richard A. Flavell, and Xin-Yuan Fu

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity
PNAS 2003 100: 1879-1884; published online before print February 5 2003, 10.1073/pnas.0237137100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Amanda E. I. Proudfoot, Tracy M. Handel, Zoë Johnson, Elaine K. Lau, Patricia LiWang, Ian Clark-Lewis, Frédéric Borlat, Timothy N. C. Wells, and Marie H. Kosco-Vilbois

Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines
PNAS 2003 100: 1885-1890; published online before print February 5 2003, 10.1073/pnas.0334864100 [Abstract] [Full Text] [PDF]  

Medical Sciences

Meili Zhang, Zhuo Zhang, Kayhan Garmestani, Jody Schultz, Donald B. Axworthy, Carolyn K. Goldman, Martin W. Brechbiel, Jorge A. Carrasquillo, and Thomas A. Waldmann

Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts
PNAS 2003 100: 1891-1895; published online before print February 4 2003, 10.1073/pnas.0437788100 [Abstract] [Full Text] [PDF]  

Adeline R. Whitney, Maximilian Diehn, Stephen J. Popper, Ash A. Alizadeh, Jennifer C. Boldrick, David A. Relman, and Patrick O. Brown

Individuality and variation in gene expression patterns in human blood
PNAS 2003 100: 1896-1901; published online before print February 10 2003, 10.1073/pnas.252784499 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kazuhiro Ohmi, David S. Greenberg, Kavitha S. Rajavel, Sergey Ryazantsev, Hong Hua Li, and Elizabeth F. Neufeld

Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB
PNAS 2003 100: 1902-1907; published online before print February 7 2003, 10.1073/pnas.252784899 [Abstract] [Full Text] [PDF]  

Tae-Wook Chun, J. Shawn Justement, Richard A. Lempicki, Jun Yang, Glynn Dennis, Jr., Claire W. Hallahan, Christina Sanford, Punita Pandya, Shuying Liu, Mary McLaughlin, Linda A. Ehler, Susan Moir, and Anthony S. Fauci

Gene expression and viral prodution in latently infected, resting CD4⁺ T cells in viremic versus aviremic HIV-infected individuals
PNAS 2003 100: 1908-1913; published online before print January 27 2003, 10.1073/pnas.0437640100 [Abstract] [Full Text] [PDF]  

Christoph Gasche, Christina L. Chang, Loki Natarajan, Ajay Goel, Jennifer Rhees, Dennis J. Young, Christian N. Arnold, and C. Richard Boland

Identification of frame-shift intermediate mutant cells
PNAS 2003 100: 1914-1919; published online before print February 10 2003, 10.1073/pnas.0437965100 [Abstract] [Full Text] [PDF]  

Angelika Bierhaus, Jutta Wolf, Martin Andrassy, Nicolas Rohleder, Per M. Humpert, Dimitri Petrov, Roman Ferstl, Maximilian von Eynatten, Thoralf Wendt, Gottfried Rudofsky, Martina Joswig, Michael Morcos, Markus Schwaninger, Bruce McEwen, Clemens Kirschbaum, and Peter P. Nawroth

A mechanism converting psychosocial stress into mononuclear cell activation
PNAS 2003 100: 1920-1925; published online before print February 10 2003, 10.1073/pnas.0438019100 [Abstract] [Full Text] [PDF]  

Sean P. Bohen, Olga G. Troyanskaya, Orly Alter, Roger Warnke, David Botstein, Patrick O. Brown, and Ronald Levy

Variation in gene expression patterns in follicular lymphoma and the response to rituximab
PNAS 2003 100: 1926-1930; published online before print February 5 2003, 10.1073/pnas.0437875100 [Abstract] [Full Text] [PDF]  

Jian Yu, Zhenghe Wang, Kenneth W. Kinzler, Bert Vogelstein, and Lin Zhang

PUMA mediates the apoptotic response to p53 in colorectal cancer cells
PNAS 2003 100: 1931-1936; published online before print February 6 2003, 10.1073/pnas.2627984100 [Abstract] [Full Text] [PDF]  

Lynda S. Ostedgaard, Christoph Randak, Tatiana Rokhlina, Philip Karp, Daniel Vermeer, Katherine J. Ashbourne Excoffon, and Michael J. Welsh

Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia
PNAS 2003 100: 1937-1942; published online before print February 10 2003, 10.1073/pnas.2627982100 [Abstract] [Full Text] [PDF]  

M. Anders, R. Hansen, R.-X. Ding, K. A. Rauen, M. J. Bissell, and W. Michael Korn

Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor
PNAS 2003 100: 1943-1948; published online before print February 7 2003, 10.1073/pnas.0337599100 [Abstract] [Full Text] [PDF]  

Fadie T. Coleman, Simone Mueschenborn, Gloria Meluleni, Christopher Ray, Vincent J. Carey, Sara O. Vargas, Carolyn L. Cannon, Frederick M. Ausubel, and Gerald B. Pier

Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection
PNAS 2003 100: 1949-1954; published online before print February 10 2003, 10.1073/pnas.0437901100 [Abstract] [Full Text] [PDF]  

Zao-zhong Su, Magdalena Leszczyniecka, Dong-chul Kang, Devanand Sarkar, Wei Chao, David J. Volsky, and Paul B. Fisher

Insights into glutamate transport regulation in human astrocytes: Cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
PNAS 2003 100: 1955-1960; published online before print February 10 2003, 10.1073/pnas.0136555100 [Abstract] [Full Text] [PDF]  

Ben Y. Reis, Marcello Pagano, and Kenneth D. Mandl

Using temporal context to improve biosurveillance
PNAS 2003 100: 1961-1965; published online before print February 6 2003, 10.1073/pnas.0335026100 [Abstract] [Full Text] [PDF]  

Richard Malley, Philipp Henneke, Sarah C. Morse, Michael J. Cieslewicz, Marc Lipsitch, Claudette M. Thompson, Evelyn Kurt-Jones, James C. Paton, Michael R. Wessels, and Douglas T. Golenbock

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
PNAS 2003 100: 1966-1971; published online before print February 4 2003, 10.1073/pnas.0435928100 [Abstract] [Full Text] [PDF]  

Vladimir P. Torchilin, Tatyana S. Levchenko, Ram Rammohan, Natalia Volodina, Brigitte Papahadjopoulos-Sternberg, and Gerard G. M. D'Souza

Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes
PNAS 2003 100: 1972-1977; published online before print February 5 2003, 10.1073/pnas.0435906100 [Abstract] [Full Text] [PDF]  

Marco Cattaneo, Maddalena L. Zighetti, Rossana Lombardi, Constantino Martinez, Anna Lecchi, Pamela B. Conley, Jerry Ware, and Zaverio M. Ruggeri

Molecular bases of defective signal transduction in the platelet P2Y₁₂ receptor of a patient with congenital bleeding
PNAS 2003 100: 1978-1983; published online before print February 10 2003, 10.1073/pnas.0437879100 [Abstract] [Full Text] [PDF]  

Microbiology

Ning Liu, Ru Tian, and Daniel D. Loeb

Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription
PNAS 2003 100: 1984-1989; published online before print February 10 2003, 10.1073/pnas.0436218100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Michiel Kleerebezem, Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos, and Roland J. Siezen

Complete genome sequence of Lactobacillus plantarum WCFS1
PNAS 2003 100: 1990-1995; published online before print February 3 2003, 10.1073/pnas.0337704100 [Abstract] [Full Text] [PDF]  

Jovanka M. Voyich, Daniel E. Sturdevant, Kevin R. Braughton, Scott D. Kobayashi, Benfang Lei, Kimmo Virtaneva, David W. Dorward, James M. Musser, and Frank R. DeLeo

Genome-wide protective response used by group A Streptococcus to evade destruction by human polymorphonuclear leukocytes
PNAS 2003 100: 1996-2001; published online before print February 6 2003, 10.1073/pnas.0337370100 [Abstract] [Full Text] [PDF] [Supporting Methods]  

Yutaka Fujii, Hideo Goto, Tokiko Watanabe, Tetsuya Yoshida, and Yoshihiro Kawaoka

Selective incorporation of influenza virus RNA segments into virions
PNAS 2003 100: 2002-2007; published online before print February 6 2003, 10.1073/pnas.0437772100 [Abstract] [Full Text] [PDF]  

John R. Kirby and David R. Zusman

Chemosensory regulation of developmental gene expression in Myxococcus xanthus
PNAS 2003 100: 2008-2013; published online before print February 3 2003, 10.1073/pnas.0330944100 [Abstract] [Full Text] [PDF]