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COMMENTARIES

Karl Münger

Clefts, grooves, and (small) pockets: The structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled
PNAS 2003 100: 2165-2167; published online before print February 26 2003, 10.1073/pnas.0630419100 [Extract] [Full Text] [PDF]  
See companion article on page 2363

Stephen R. Hammes

The further redefining of steroid-mediated signaling
PNAS 2003 100: 2168-2170; published online before print February 26 2003, 10.1073/pnas.0530224100 [Extract] [Full Text] [PDF]  
See companion article on page 2231
See companion article on page 2237

Timothy A. Ryan

Kiss-and-run, fuse-pinch-and-linger, fuse-and-collapse: The life and times of a neurosecretory granule
PNAS 2003 100: 2171-2173; published online before print February 26 2003, 10.1073/pnas.0530260100 [Extract] [Full Text] [PDF]  
See companion article on page 2070 in issue 4 of volume 100

Pinar E. Coskun, Eduardo Ruiz-Pesini, and Douglas C. Wallace

Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum
PNAS 2003 100: 2174-2176; published online before print February 26 2003, 10.1073/pnas.0630589100 [Extract] [Full Text] [PDF]  
See companion article on page 1116 in issue 3 of volume 100

Randy L. Buckner

The hemodynamic inverse problem: Making inferences about neural activity from measured MRI signals
PNAS 2003 100: 2177-2179; published online before print February 26 2003, 10.1073/pnas.0630492100 [Extract] [Full Text] [PDF]  
See companion article on page 1415 in issue 3 of volume 100

PHYSICAL SCIENCES

Applied Physical Sciences

Chemistry

S. Tretiak, A. Saxena, R. L. Martin, and A. R. Bishop

Photoexcited breathers in conjugated polyenes: An excited-state molecular dynamics study
PNAS 2003 100: 2185-2190; published online before print February 19 2003, 10.1073/pnas.0530132100 [Abstract] [Full Text] [PDF]  

Ariel Fernández and R. Stephen Berry

Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis
PNAS 2003 100: 2391-2396; published online before print February 18 2003, 10.1073/pnas.0335642100 [Abstract] [Full Text] [PDF]  

Computer Sciences

Yaakov Benenson, Rivka Adar, Tamar Paz-Elizur, Zvi Livneh, and Ehud Shapiro

DNA molecule provides a computing machine with both data and fuel
PNAS 2003 100: 2191-2196; published online before print February 24 2003, 10.1073/pnas.0535624100 [Abstract] [Full Text] [PDF]  

Engineering

David L. Donoho and Michael Elad

Optimally sparse representation in general (nonorthogonal) dictionaries via ¹ minimization
PNAS 2003 100: 2197-2202; published online before print February 21 2003, 10.1073/pnas.0437847100 [Abstract] [Full Text] [PDF]  

Mathematics

Herbert Edelsbrunner and Patrice Koehl

The weighted-volume derivative of a space-filling diagram
PNAS 2003 100: 2203-2208; published online before print February 24 2003, 10.1073/pnas.0537830100 [Abstract] [Full Text] [PDF]  

Physics

Yaakov Benenson, Rivka Adar, Tamar Paz-Elizur, Zvi Livneh, and Ehud Shapiro

DNA molecule provides a computing machine with both data and fuel
PNAS 2003 100: 2191-2196; published online before print February 24 2003, 10.1073/pnas.0535624100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Economic Sciences

Psychology

Elise Temple, Gayle K. Deutsch, Russell A. Poldrack, Steven L. Miller, Paula Tallal, Michael M. Merzenich, and John D. E. Gabrieli

Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI
PNAS 2003 100: 2860-2865; published online before print February 25 2003, 10.1073/pnas.0030098100 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Punchapat Sojikul, Norene Buehner, and Hugh S. Mason

A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells
PNAS 2003 100: 2209-2214; published online before print February 24 2003, 10.1073/pnas.0438037100 [Abstract] [Full Text] [PDF]  

Biochemistry

Sun Hur, Kalju Kahn, and Thomas C. Bruice

Comparison of formation of reactive conformers for the S_N2 displacements by CH₃CO in water and by Asp124-CO in a haloalkane dehalogenase
PNAS 2003 100: 2215-2219; published online before print February 27 2003, 10.1073/pnas.242721799 [Abstract] [Full Text] [PDF]  

Eda Yildirim, Alexander Dietrich, and Lutz Birnbaumer

The mouse C-type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N terminus
PNAS 2003 100: 2220-2225; published online before print February 24 2003, 10.1073/pnas.0438036100 [Abstract] [Full Text] [PDF]  

Maggie C. Louie, Hong Qiong Yang, Ai-Hong Ma, Wei Xu, June X. Zou, Hsing-Jien Kung, and Hong-Wu Chen

Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex
PNAS 2003 100: 2226-2230; published online before print February 14 2003, 10.1073/pnas.0437824100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yong Zhu, Charles D. Rice, Yefei Pang, Margaret Pace, and Peter Thomas From the Cover: Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes PNAS 2003 100: 2231-2236; published online before print February 6 2003, 10.1073/pnas.0336132100 [Abstract] [Full Text] [PDF] [Supporting Information]   See Commentary on page 2168

Yong Zhu, Jason Bond, and Peter Thomas

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
PNAS 2003 100: 2237-2242; published online before print February 24 2003, 10.1073/pnas.0436133100 [Abstract] [Full Text] [PDF] [Supporting Information]  
See Commentary on page 2168

Vivek Sharma, Arulandu Arockiasamy, Donald R. Ronning, Christos G. Savva, Andreas Holzenburg, Miriam Braunstein, William R. Jacobs, Jr., and James C. Sacchettini

Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase
PNAS 2003 100: 2243-2248; published online before print February 26 2003, 10.1073/pnas.0538077100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jerzy Majka and Peter M. J. Burgers

Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint
PNAS 2003 100: 2249-2254; published online before print February 25 2003, 10.1073/pnas.0437148100 [Abstract] [Full Text] [PDF]  

Sung-Hye Hong and Wolfgang Maret

A fluorescence resonance energy transfer sensor for the -domain of metallothionein
PNAS 2003 100: 2255-2260. [Abstract] [Full Text] [PDF]  

Manas K. Chattopadhyay, Celia White Tabor, and Herbert Tabor

Polyamines protect Escherichia coli cells from the toxic effect of oxygen
PNAS 2003 100: 2261-2265; published online before print February 18 2003, 10.1073/pnas.2627990100 [Abstract] [Full Text] [PDF]  

Brian K. Yeh, Makoto Igarashi, Anna V. Eliseenkova, Alexander N. Plotnikov, Ifat Sher, Dina Ron, Stuart A. Aaronson, and Moosa Mohammadi

Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors
PNAS 2003 100: 2266-2271; published online before print February 18 2003, 10.1073/pnas.0436500100 [Abstract] [Full Text] [PDF]  

David A. Calderwood, Yosuke Fujioka, Jose M. de Pereda, Begoña García-Alvarez, Tetsuya Nakamoto, Ben Margolis, C. Jane McGlade, Robert C. Liddington, and Mark H. Ginsberg

Integrin cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling
PNAS 2003 100: 2272-2277; published online before print February 26 2003, 10.1073/pnas.262791999 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Patricia Bordes, Siva R. Wigneshweraraj, Jörg Schumacher, Xiaodong Zhang, Matthew Chaney, and Martin Buck

The ATP hydrolyzing transcription activator phage shock protein F of Escherichia coli: Identifying a surface that binds ⁵⁴
PNAS 2003 100: 2278-2283; published online before print February 24 2003, 10.1073/pnas.0537525100 [Abstract] [Full Text] [PDF]  

Brent J. Passer, Vanessa Nancy-Portebois, Nathalie Amzallag, Sylvie Prieur, Christophe Cans, Aude Roborel de Climens, Giusy Fiucci, Véronique Bouvard, Marcel Tuynder, Laurent Susini, Stéphanie Morchoisne, Virginie Crible, Alexandra Lespagnol, Jean Dausset, Moshe Oren, Robert Amson, and Adam Telerman

The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase
PNAS 2003 100: 2284-2289; published online before print February 26 2003, 10.1073/pnas.0530298100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Olaf Fritze, Sawomir Filipek, Vladimir Kuksa, Krzysztof Palczewski, Klaus Peter Hofmann, and Oliver P. Ernst

Role of the conserved NPxxY(x)_5,6F motif in the rhodopsin ground state and during activation
PNAS 2003 100: 2290-2295; published online before print February 24 2003, 10.1073/pnas.0435715100 [Abstract] [Full Text] [PDF]  

Katsuhiko Kamada, Robert G. Roeder, and Stephen K. Burley

Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF
PNAS 2003 100: 2296-2299; published online before print February 18 2003, 10.1073/pnas.262798199 [Abstract] [Full Text] [PDF]  

Katrin Karbstein and Daniel Herschlag

Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: Implications for RNA preorganization and function
PNAS 2003 100: 2300-2305; published online before print February 18 2003, 10.1073/pnas.252749799 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tilman Schlothauer, Axel Mogk, David A. Dougan, Bernd Bukau, and Kürad Turgay

MecA, an adaptor protein necessary for ClpC chaperone activity
PNAS 2003 100: 2306-2311; published online before print February 21 2003, 10.1073/pnas.0535717100 [Abstract] [Full Text] [PDF]  

Hiromi Imamura, Masahiro Nakano, Hiroyuki Noji, Eiro Muneyuki, Shoji Ohkuma, Masasuke Yoshida, and Ken Yokoyama

Evidence for rotation of V₁-ATPase
PNAS 2003 100: 2312-2315; published online before print February 21 2003, 10.1073/pnas.0436796100 [Abstract] [Full Text] [PDF]  

Florence Pojer, Emmanuel Wemakor, Bernd Kammerer, Huawei Chen, Christopher T. Walsh, Shu-Ming Li, and Lutz Heide

CloQ, a prenyltransferase involved in clorobiocin biosynthesis
PNAS 2003 100: 2316-2321. [Abstract] [Full Text] [PDF]  

Philip Ian Padilla, Min-ju Chang, Gustavo Pacheco-Rodriguez, Ronald Adamik, Joel Moss, and Martha Vaughan

Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506
PNAS 2003 100: 2322-2327; published online before print February 26 2003, 10.1073/pnas.2628047100 [Abstract] [Full Text] [PDF]  

Erika M. Friedl, William S. Lane, Hediye Erdjument-Bromage, Paul Tempst, and Danny Reinberg

The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation
PNAS 2003 100: 2328-2333; published online before print February 18 2003, 10.1073/pnas.2628049100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Joon-Kyu Lee, Yeon-Soo Seo, and Jerard Hurwitz

The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase
PNAS 2003 100: 2334-2339; published online before print February 25 2003, 10.1073/pnas.0237384100 [Abstract] [Full Text] [PDF]  

Biophysics

Herbert Edelsbrunner and Patrice Koehl

The weighted-volume derivative of a space-filling diagram
PNAS 2003 100: 2203-2208; published online before print February 24 2003, 10.1073/pnas.0537830100 [Abstract] [Full Text] [PDF]  

Adrian H. Elcock

Atomic-level observation of macromolecular crowding effects: Escape of a protein from the GroEL cage
PNAS 2003 100: 2340-2344; published online before print February 24 2003, 10.1073/pnas.0535055100 [Abstract] [Full Text] [PDF]  

Kelly R. LeFevre and Matthew H. J. Cordes

Retroevolution of Cro toward a stable monomer
PNAS 2003 100: 2345-2350; published online before print February 21 2003, 10.1073/pnas.0537925100 [Abstract] [Full Text] [PDF]  

Steven M. Block, Charles L. Asbury, Joshua W. Shaevitz, and Matthew J. Lang

Probing the kinesin reaction cycle with a 2D optical force clamp
PNAS 2003 100: 2351-2356; published online before print February 18 2003, 10.1073/pnas.0436709100 [Abstract] [Full Text] [PDF]  

Rahul Raman, Ganesh Venkataraman, Steffen Ernst, V. Sasisekharan, and Ram Sasisekharan

Structural specificity of heparin binding in the fibroblast growth factor family of proteins
PNAS 2003 100: 2357-2362; published online before print February 25 2003, 10.1073/pnas.0437842100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Bing Xiao, James Spencer, Adrienne Clements, Nadeem Ali-Khan, Sibylle Mittnacht, Cristina Broceño, Manfred Burghammer, Anastassis Perrakis, Ronen Marmorstein, and Steven J. Gamblin From the Cover: Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation PNAS 2003 100: 2363-2368; published online before print February 21 2003, 10.1073/pnas.0436813100 [Abstract] [Full Text] [PDF] [Supporting Figures]   See Commentary on page 2165

Andrej Barbi, Daniel P. Zimmer, and Donald M. Crothers

Structural origins of adenine-tract bending
PNAS 2003 100: 2369-2373; published online before print February 13 2003, 10.1073/pnas.0437877100 [Abstract] [Full Text] [PDF]  

Masaki Sasai and Peter G. Wolynes

Stochastic gene expression as a many-body problem
PNAS 2003 100: 2374-2379; published online before print February 26 2003, 10.1073/pnas.2627987100 [Abstract] [Full Text] [PDF]  

Michael E. Wall, Sharron H. Francis, Jackie D. Corbin, Kennard Grimes, Robyn Richie-Jannetta, Jun Kotera, Brian A. Macdonald, Rowena R. Gibson, and Jill Trewhella

Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase
PNAS 2003 100: 2380-2385; published online before print February 18 2003, 10.1073/pnas.0534892100 [Abstract] [Full Text] [PDF]  

Jingtong Hou, Gregory E. Sims, Chao Zhang, and Sung-Hou Kim

A global representation of the protein fold space
PNAS 2003 100: 2386-2390; published online before print February 26 2003, 10.1073/pnas.2628030100 [Abstract] [Full Text] [PDF]  

Ariel Fernández and R. Stephen Berry

Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis
PNAS 2003 100: 2391-2396; published online before print February 18 2003, 10.1073/pnas.0335642100 [Abstract] [Full Text] [PDF]  

Bing-Hao Luo, Timothy A. Springer, and Junichi Takagi

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand
PNAS 2003 100: 2403-2408; published online before print February 25 2003, 10.1073/pnas.0438060100 [Abstract] [Full Text] [PDF]  

Cell Biology

Jeffrey L. Spees, Scott D. Olson, Joni Ylostalo, Patrick J. Lynch, Jason Smith, Anthony Perry, Alexandra Peister, Meng Yu Wang, and Darwin J. Prockop

Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma
PNAS 2003 100: 2397-2402; published online before print February 26 2003, 10.1073/pnas.0437997100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Bing-Hao Luo, Timothy A. Springer, and Junichi Takagi

Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand
PNAS 2003 100: 2403-2408; published online before print February 25 2003, 10.1073/pnas.0438060100 [Abstract] [Full Text] [PDF]  

S. Iuchi, G. Hoffner, P. Verbeke, P. Djian, and H. Green

Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine
PNAS 2003 100: 2409-2414; published online before print February 18 2003, 10.1073/pnas.0437660100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Heyu Ni, Peter S. T. Yuen, Jessie M. Papalia, Jane E. Trevithick, Takao Sakai, Reinhard Fässler, Richard O. Hynes, and Denisa D. Wagner

Plasma fibronectin promotes thrombus growth and stability in injured arterioles
PNAS 2003 100: 2415-2419; published online before print February 26 2003, 10.1073/pnas.2628067100 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Hideki Shimodaira, Atsuko Yoshioka-Yamashita, Richard D. Kolodner, and Jean Y. J. Wang

Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
PNAS 2003 100: 2420-2425; published online before print February 24 2003, 10.1073/pnas.0438031100 [Abstract] [Full Text] [PDF]  

Yong Zhao, David Glesne, and Eliezer Huberman

A human peripheral blood monocyte-derived subset acts as pluripotent stem cells
PNAS 2003 100: 2426-2431; published online before print February 26 2003, 10.1073/pnas.0536882100 [Abstract] [Full Text] [PDF]  

Kui Lei and Roger J. Davis

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
PNAS 2003 100: 2432-2437; published online before print February 18 2003, 10.1073/pnas.0438011100 [Abstract] [Full Text] [PDF]  

Jing Bao, Gal Gur, and Yosef Yarden

Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors
PNAS 2003 100: 2438-2443; published online before print February 25 2003, 10.1073/pnas.0437945100 [Abstract] [Full Text] [PDF]  

Ulrike Krummrei, Etienne-Emile Baulieu, and Béatrice Chambraud

The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis
PNAS 2003 100: 2444-2449; published online before print February 25 2003, 10.1073/pnas.0438007100 [Abstract] [Full Text] [PDF]  

Daniel P. Denning, Samir S. Patel, Vladimir Uversky, Anthony L. Fink, and Michael Rexach

Disorder in the nuclear pore complex: The FG repeat regions of nucleoporins are natively unfolded
PNAS 2003 100: 2450-2455; published online before print February 25 2003, 10.1073/pnas.0437902100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rebecca L. Landsberg, Julia E. Sero, Paul S. Danielian, Tina L. Yuan, Eunice Y. Lee, and Jacqueline A. Lees

The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity
PNAS 2003 100: 2456-2461; published online before print February 25 2003, 10.1073/pnas.0138064100 [Abstract] [Full Text] [PDF]  

Y. Dai, B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo, M. Stumm, T. O. Harville, S. C. West, M. A. Oettinger, and P. A. Jeggo

Nonhomologous end joining and V(D)J recombination require an additional factor
PNAS 2003 100: 2462-2467; published online before print February 25 2003, 10.1073/pnas.0437964100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Developmental Biology

Jan Willem Voncken, Bernard A. J. Roelen, Mieke Roefs, Stijn de Vries, Els Verhoeven, Silvia Marino, Jacqueline Deschamps, and Maarten van Lohuizen

Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition
PNAS 2003 100: 2468-2473; published online before print February 14 2003, 10.1073/pnas.0434312100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Ecology

Nathan J. Sanders, Nicholas J. Gotelli, Nicole E. Heller, and Deborah M. Gordon

Community disassembly by an invasive species
PNAS 2003 100: 2474-2477; published online before print February 25 2003, 10.1073/pnas.0437913100 [Abstract] [Full Text] [PDF]  

Rowan Lockwood

Abundance not linked to survival across the end-Cretaceous mass extinction: Patterns in North American bivalves
PNAS 2003 100: 2478-2482; published online before print February 24 2003, 10.1073/pnas.0535132100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Kathleen R. Laird, Brian F. Cumming, Sybille Wunsam, James A. Rusak, Robert J. Oglesby, Sherilyn C. Fritz, and Peter R. Leavitt

Lake sediments record large-scale shifts in moisture regimes across the northern prairies of North America during the past two millennia
PNAS 2003 100: 2483-2488; published online before print February 26 2003, 10.1073/pnas.0530193100 [Abstract] [Full Text] [PDF]  

Evolution

Junhua Peng, Yefim Ronin, Tzion Fahima, Marion S. Röder, Youchun Li, Eviatar Nevo, and Abraham Korol

Domestication quantitative trait loci in Triticum dicoccoides, the progenitor of wheat
PNAS 2003 100: 2489-2494; published online before print February 25 2003, 10.1073/pnas.252763199 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Volodymyr Dvornyk, Oxana Vinogradova, and Eviatar Nevo

Origin and evolution of circadian clock genes in prokaryotes
PNAS 2003 100: 2495-2500; published online before print February 25 2003, 10.1073/pnas.0130099100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Tatsuya Ota, Jonathan P. Rast, Gary W. Litman, and Chris T. Amemiya

Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox
PNAS 2003 100: 2501-2506; published online before print February 26 2003, 10.1073/pnas.0538029100 [Abstract] [Full Text] [PDF]  

Charles A. Paulding, Maryellen Ruvolo, and Daniel A. Haber

The Tre2 (USP6) oncogene is a hominoid-specific gene
PNAS 2003 100: 2507-2511; published online before print February 25 2003, 10.1073/pnas.0437015100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Genetics

Natalia Friedland, Heng-Ling Liou, Peter Lobel, and Ann M. Stock

Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease
PNAS 2003 100: 2512-2517; published online before print February 18 2003, 10.1073/pnas.0437840100 [Abstract] [Full Text] [PDF]  

Dennis C. Ko, Jonathan Binkley, Arend Sidow, and Matthew P. Scott Inaugural Article by a Recently Elected Academy Member: Inaugural Article: The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels PNAS 2003 100: 2518-2525; published online before print February 18 2003, 10.1073/pnas.0530027100 [Abstract] [Full Text] [PDF]

Kelvin Y. Kwan, Peter B. Moens, and James C. Wang

Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III
PNAS 2003 100: 2526-2531; published online before print February 18 2003, 10.1073/pnas.0437998100 [Abstract] [Full Text] [PDF]  

Ingrid Hedenfalk, Markus Ringnér, Amir Ben-Dor, Zohar Yakhini, Yidong Chen, Gunilla Chebil, Robert Ach, Niklas Loman, Håkan Olsson, Paul Meltzer, Åke Borg, and Jeffrey Trent

Molecular classification of familial non-BRCA1/BRCA2 breast cancer
PNAS 2003 100: 2532-2537; published online before print February 27 2003, 10.1073/pnas.0533805100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Vardhman K. Rakyan, Suyinn Chong, Marnie E. Champ, Peter C. Cuthbert, Hugh D. Morgan, Keith V. K. Luu, and Emma Whitelaw

Transgenerational inheritance of epigenetic states at the murine Axin^Fu allele occurs after maternal and paternal transmission
PNAS 2003 100: 2538-2543; published online before print February 24 2003, 10.1073/pnas.0436776100 [Abstract] [Full Text] [PDF]  

Huilan Chen, Shiping Wang, Yongzhong Xing, Caiguo Xu, Patrick M. Hayes, and Qifa Zhang

Comparative analyses of genomic locations and race specificities of loci for quantitative resistance to Pyricularia grisea in rice and barley
PNAS 2003 100: 2544-2549; published online before print February 24 2003, 10.1073/pnas.0437898100 [Abstract] [Full Text] [PDF]  

Steven P. Hamilton, Abby J. Fyer, Martina Durner, Gary A. Heiman, Ada Baisre de Leon, Susan E. Hodge, James A. Knowles, and Myrna M. Weissman

Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q
PNAS 2003 100: 2550-2555; published online before print February 25 2003, 10.1073/pnas.0335669100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Wei J. Gong and Kent G. Golic

Ends-out, or replacement, gene targeting in Drosophila
PNAS 2003 100: 2556-2561; published online before print February 14 2003, 10.1073/pnas.0535280100 [Abstract] [Full Text] [PDF]  

Dorian McIlroy, Pierre-François Cartron, Pierre Tuffery, Yasmine Dudoit, Assia Samri, Brigitte Autran, François M. Vallette, Patrice Debré, and Ioannis Theodorou

A triple-mutated allele of granzyme B incapable of inducing apoptosis
PNAS 2003 100: 2562-2567; published online before print February 19 2003, 10.1073/pnas.0437935100 [Abstract] [Full Text] [PDF]  

Rosa Esteban and Tsutomu Fujimura

Launching the yeast 23S RNA Narnavirus shows 5' and 3' cis-acting signals for replication
PNAS 2003 100: 2568-2573; published online before print February 18 2003, 10.1073/pnas.0530167100 [Abstract] [Full Text] [PDF]  

Jinping Hua, Yongzhong Xing, Weiren Wu, Caiguo Xu, Xinli Sun, Sibin Yu, and Qifa Zhang

Single-locus heterotic effects and dominance by dominance interactions can adequately explain the genetic basis of heterosis in an elite rice hybrid
PNAS 2003 100: 2574-2579; published online before print February 25 2003, 10.1073/pnas.0437907100 [Abstract] [Full Text] [PDF]  

Bas van Steensel, Jeffrey Delrow, and Harmen J. Bussemaker

Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding
PNAS 2003 100: 2580-2585; published online before print February 24 2003, 10.1073/pnas.0438000100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Xuewu Zhang, Jean-Claude D. Schwartz, Steven C. Almo, and Stanley G. Nathenson

Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling
PNAS 2003 100: 2586-2591; published online before print February 26 2003, 10.1073/pnas.252771499 [Abstract] [Full Text] [PDF] [Supporting Table]  

G. Panyi, M. Bagdány, A. Bodnár, G. Vámosi, G. Szentesi, A. Jenei, L. Mátyus, S. Varga, T. A. Waldmann, R. Gáspár, and S. Damjanovich

Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes
PNAS 2003 100: 2592-2597; published online before print February 25 2003, 10.1073/pnas.0438057100 [Abstract] [Full Text] [PDF]  

Craig H. Bassing, Robert E. Tillman, Barbara B. Woodman, David Canty, Robert J. Monroe, Barry P. Sleckman, and Frederick W. Alt

T cell receptor (TCR) / locus enhancer identity and position are critical for the assembly of TCR and variable region genes
PNAS 2003 100: 2598-2603; published online before print February 25 2003, 10.1073/pnas.0437943100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Mark J. Miller, Sindy H. Wei, Michael D. Cahalan, and Ian Parker

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy
PNAS 2003 100: 2604-2609; published online before print February 24 2003, 10.1073/pnas.2628040100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Emily C. Baechler, Franak M. Batliwalla, George Karypis, Patrick M. Gaffney, Ward A. Ortmann, Karl J. Espe, Katherine B. Shark, William J. Grande, Karis M. Hughes, Vivek Kapur, Peter K. Gregersen, and Timothy W. Behrens

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
PNAS 2003 100: 2610-2615; published online before print February 25 2003, 10.1073/pnas.0337679100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sang Woon Shin, Vladimir Kokoza, Iouri Lobkov, and Alexander S. Raikhel

Relish-mediated immune deficiency in the transgenic mosquito Aedes aegypti
PNAS 2003 100: 2616-2621; published online before print February 19 2003, 10.1073/pnas.0537347100 [Abstract] [Full Text] [PDF]  

Eva Kurucz, Carl-Johan Zettervall, Rita Sinka, Peter Vilmos, Andor Pivarcsi, Sophia Ekengren, Zoltán Hegedüs, Istvan Ando, and Dan Hultmark

Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila
PNAS 2003 100: 2622-2627; published online before print February 21 2003, 10.1073/pnas.0436940100 [Abstract] [Full Text] [PDF]  

Morris O. Makobongo, George Riding, Huji Xu, Chakrit Hirunpetcharat, Dianne Keough, John de Jersey, Peter Willadsen, and Michael F. Good

The purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyl transferase is a major target antigen for cell-mediated immunity to malaria
PNAS 2003 100: 2628-2633; published online before print February 19 2003, 10.1073/pnas.0337629100 [Abstract] [Full Text] [PDF]  

Tomomitsu Doi, Kazuo Kinoshita, Masaya Ikegawa, Masamichi Muramatsu, and Tasuku Honjo Inaugural Article by a Recently Elected Academy Member: Inaugural Article: De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination PNAS 2003 100: 2634-2638; published online before print February 18 2003, 10.1073/pnas.0437710100 [Abstract] [Full Text] [PDF] [Supporting Figure]

Ulf Klein, Yuhai Tu, Gustavo A. Stolovitzky, Jeffrey L. Keller, Joseph Haddad, Jr., Vladan Miljkovic, Giorgio Cattoretti, Andrea Califano, and Riccardo Dalla-Favera

Transcriptional analysis of the B cell germinal center reaction
PNAS 2003 100: 2639-2644; published online before print February 25 2003, 10.1073/pnas.0437996100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Elena Voronov, Dror S. Shouval, Yakov Krelin, Emanuela Cagnano, Daniel Benharroch, Yoichiro Iwakura, Charles A. Dinarello, and Ron N. Apte

IL-1 is required for tumor invasiveness and angiogenesis
PNAS 2003 100: 2645-2650; published online before print February 21 2003, 10.1073/pnas.0437939100 [Abstract] [Full Text] [PDF]  

Sang-Yull Lee, Yuichi Obata, Masahiro Yoshida, Elisabeth Stockert, Barbara Williamson, Achim A. Jungbluth, Yao-Tseng Chen, Lloyd J. Old, and Matthew J. Scanlan

Immunomic analysis of human sarcoma
PNAS 2003 100: 2651-2656; published online before print February 24 2003, 10.1073/pnas.0437972100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Barbara J. Johnson, Elaine O. Costelloe, David R. Fitzpatrick, John B. A. G. Haanen, Ton N. M. Schumacher, Lorena E. Brown, and Anne Kelso

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8⁺ T cells in influenza virus-infected mice
PNAS 2003 100: 2657-2662; published online before print February 24 2003, 10.1073/pnas.0538056100 [Abstract] [Full Text] [PDF]  

Thomas Ranson, Christian A. J. Vosshenrich, Erwan Corcuff, Odile Richard, Veronique Laloux, Agnès Lehuen, and James P. Di Santo

IL-15 availability conditions homeostasis of peripheral natural killer T cells
PNAS 2003 100: 2663-2668; published online before print February 21 2003, 10.1073/pnas.0535482100 [Abstract] [Full Text] [PDF]  

Medical Sciences

Carole Vogler, Nancy Galvin, Beth Levy, Jeffery Grubb, Jinxing Jiang, Xiao Yan Zhou, and William S. Sly

Transgene produces massive overexpression of human -glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors
PNAS 2003 100: 2669-2673; published online before print February 18 2003, 10.1073/pnas.0437941100 [Abstract] [Full Text] [PDF]  

Youzhi Li, Xiangao Sun, J. Thomas LaMont, Arthur B. Pardee, and Chiang J. Li

Selective killing of cancer cells by -lapachone: Direct checkpoint activation as a strategy against cancer
PNAS 2003 100: 2674-2678; published online before print February 21 2003, 10.1073/pnas.0538044100 [Abstract] [Full Text] [PDF]  

Puran S. Bora, Zhiwei Hu, Tongalp H. Tezel, Jeong-Hyeon Sohn, Shin Goo Kang, Jose M. C. Cruz, Nalini S. Bora, Alan Garen, and Henry J. Kaplan

Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration
PNAS 2003 100: 2679-2684; published online before print February 14 2003, 10.1073/pnas.0438014100 [Abstract] [Full Text] [PDF]  

Jennifer LeCouter, Rui Lin, Max Tejada, Gretchen Frantz, Franklin Peale, Kenneth J. Hillan, and Napoleone Ferrara

The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells
PNAS 2003 100: 2685-2690; published online before print February 25 2003, 10.1073/pnas.0337667100 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

Cristina Simões, Ole Jensen, Lauri Parkkonen, and Riitta Hari

Phase locking between human primary and secondary somatosensory cortices
PNAS 2003 100: 2691-2694; published online before print February 21 2003, 10.1073/pnas.0437944100 [Abstract] [Full Text] [PDF]  

G. M. Pitari, L. V. Zingman, D. M. Hodgson, A. E. Alekseev, S. Kazerounian, M. Bienengraeber, G. Hajnóczky, A. Terzic, and S. A. Waldman

Bacterial enterotoxins are associated with resistance to colon cancer
PNAS 2003 100: 2695-2699; published online before print February 19 2003, 10.1073/pnas.0434905100 [Abstract] [Full Text] [PDF]  
See Commentary on page 3018

Oliver Dewald, Nikolaos G. Frangogiannis, Martin Zoerlein, Georg D. Duerr, Christina Klemm, Pascal Knuefermann, George Taffet, Lloyd H. Michael, James D. Crapo, Armin Welz, and Mark L. Entman

Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species
PNAS 2003 100: 2700-2705; published online before print February 13 2003, 10.1073/pnas.0438035100 [Abstract] [Full Text] [PDF]  

Anna V. Kuznetsova, Jaroslaw Meller, Phillip O. Schnell, James A. Nash, Monika L. Ignacak, Yolanda Sanchez, Joan W. Conaway, Ronald C. Conaway, and Maria F. Czyzyk-Krzeska

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
PNAS 2003 100: 2706-2711; published online before print February 25 2003, 10.1073/pnas.0436037100 [Abstract] [Full Text] [PDF] [Supporting Figure]