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EDITORIAL

Jack Halpern and Kenneth N. Raymond

Bioinorganic Chemistry Special Feature: At the interface of inorganic chemistry and biology
PNAS 2003 100: 3562. [Extract] [Full Text] [PDF]  

COMMENTARIES

Jeffrey N. Stuart and Jonathan V. Sweedler

Ultrafast capillary electrophoresis and bioanalytical applications
PNAS 2003 100: 3545-3546; published online before print March 25 2003, 10.1073/pnas.0830869100 [Extract] [Full Text] [PDF]  
See companion article on page 3853

John E. Dick

Breast cancer stem cells revealed
PNAS 2003 100: 3547-3549; published online before print March 25 2003, 10.1073/pnas.0830967100 [Extract] [Full Text] [PDF]  
See companion article on page 3983

Seong-Gi Kim

Progress in understanding functional imaging signals
PNAS 2003 100: 3550-3552; published online before print March 25 2003, 10.1073/pnas.0730809100 [Extract] [Full Text] [PDF]  
See companion article on page 4239

Lynne Regan

Molten globules move into action
PNAS 2003 100: 3553-3554; published online before print March 25 2003, 10.1073/pnas.0830651100 [Extract] [Full Text] [PDF]  
See companion article on page 3191 in issue 6 of volume 100

Vijay S. Pande

Meeting halfway on the bridge between protein folding theory and experiment
PNAS 2003 100: 3555-3556; published online before print March 25 2003, 10.1073/pnas.0830965100 [Extract] [Full Text] [PDF]  
See companion article on page 3948
See companion article on page 3954

Geoffrey I. McFadden and Stuart A. Ralph

Dynamin: The endosymbiosis ring of power?
PNAS 2003 100: 3557-3559; published online before print March 25 2003, 10.1073/pnas.0831049100 [Extract] [Full Text] [PDF]  
See companion article on page 4328

Mark F. Teaford

Looking at teeth in a new light
PNAS 2003 100: 3560-3561; published online before print March 25 2003, 10.1073/pnas.0831168100 [Extract] [Full Text] [PDF]  
See companion article on page 3874

PERSPECTIVES

Harry B. Gray

Bioinorganic Chemistry Special Feature: Biological inorganic chemistry at the beginning of the 21st century
PNAS 2003 100: 3563-3568; published online before print March 25 2003, 10.1073/pnas.0730378100 [Abstract] [Full Text] [PDF]  

John T. Groves

Bioinorganic Chemistry Special Feature: The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies
PNAS 2003 100: 3569-3574; published online before print March 24 2003, 10.1073/pnas.0830019100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Brian M. Hoffman

Bioinorganic Chemistry Special Feature: Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry
PNAS 2003 100: 3575-3578; published online before print March 17 2003, 10.1073/pnas.0636464100 [Abstract] [Full Text] [PDF]  

Heather M. Baker, Bryan F. Anderson, and Edward N. Baker

Bioinorganic Chemistry Special Feature: Dealing with iron: Common structural principles in proteins that transport iron and heme
PNAS 2003 100: 3579-3583; published online before print March 17 2003, 10.1073/pnas.0637295100 [Abstract] [Full Text] [PDF]  

Kenneth N. Raymond, Emily A. Dertz, and Sanggoo S. Kim

Bioinorganic Chemistry Special Feature: Enterobactin: An archetype for microbial iron transport
PNAS 2003 100: 3584-3588; published online before print March 24 2003, 10.1073/pnas.0630018100 [Abstract] [Full Text] [PDF]  

Edward I. Solomon, Andrea Decker, and Nicolai Lehnert

Bioinorganic Chemistry Special Feature: Non-heme iron enzymes: Contrasts to heme catalysis
PNAS 2003 100: 3589-3594; published online before print February 21 2003, 10.1073/pnas.0336792100 [Abstract] [Full Text] [PDF]  

Sonny C. Lee and Richard H. Holm

Bioinorganic Chemistry Special Feature: Speculative synthetic chemistry and the nitrogenase problem
PNAS 2003 100: 3595-3600; published online before print March 17 2003, 10.1073/pnas.0630028100 [Abstract] [Full Text] [PDF]  

Ivano Bertini and Antonio Rosato

Bioinorganic Chemistry Special Feature: Bioinorganic chemistry in the postgenomic era
PNAS 2003 100: 3601-3604; published online before print March 24 2003, 10.1073/pnas.0736657100 [Abstract] [Full Text] [PDF]  

Shawn C. Burdette and Stephen J. Lippard

Bioinorganic Chemistry Special Feature: Meeting of the minds: Metalloneurochemistry
PNAS 2003 100: 3605-3610; published online before print March 24 2003, 10.1073/pnas.0637711100 [Abstract] [Full Text] [PDF]  

Jan Reedijk

Bioinorganic Chemistry Special Feature: New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA
PNAS 2003 100: 3611-3616; published online before print March 24 2003, 10.1073/pnas.0737293100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Joan Selverstone Valentine and P. John Hart

Bioinorganic Chemistry Special Feature: Misfolded CuZnSOD and amyotrophic lateral sclerosis
PNAS 2003 100: 3617-3622; published online before print March 24 2003, 10.1073/pnas.0730423100 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Rafail V. Abramov and Andrew J. Majda

Statistically relevant conserved quantities for truncated quasigeostrophic flow
PNAS 2003 100: 3841-3846; published online before print March 17 2003, 10.1073/pnas.0230451100 [Abstract] [Full Text] [PDF]  

Applied Physical Sciences

S. Peng, B. Urbanc, L. Cruz, B. T. Hyman, and H. E. Stanley

Neuron recognition by parallel Potts segmentation
PNAS 2003 100: 3847-3852; published online before print March 21 2003, 10.1073/pnas.0230490100 [Abstract] [Full Text] [PDF]  

Chemistry

Eunsuk Kim, Matthew E. Helton, Ian M. Wasser, Kenneth D. Karlin, Shen Lu, Hong-wei Huang, Pierre Moënne-Loccoz, Christopher D. Incarvito, Arnold L. Rheingold, Marcus Honecker, Susan Kaderli, and Andreas D. Zuberbühler

Bioinorganic Chemistry Special Feature: Superoxo, µ-peroxo, and µ-oxo complexes from heme/O₂ and heme-Cu/O₂ reactivity: Copper ligand influences in cytochrome c oxidase models
PNAS 2003 100: 3623-3628; published online before print March 24 2003, 10.1073/pnas.0737180100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jeffrey A. Sigman, Hyeon K. Kim, Xuan Zhao, James R. Carey, and Yi Lu

Bioinorganic Chemistry Special Feature: The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin
PNAS 2003 100: 3629-3634; published online before print March 24 2003, 10.1073/pnas.0737308100 [Abstract] [Full Text] [PDF]  

Christopher J. Cramer, William B. Tolman, Klaus H. Theopold, and Arnold L. Rheingold

Bioinorganic Chemistry Special Feature: Variable character of OO and MO bonding in side-on (²) 1:1 metal complexes of O₂
PNAS 2003 100: 3635-3640; published online before print March 12 2003, 10.1073/pnas.0535926100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Roshan Perera, Masanori Sono, Jeffrey A. Sigman, Thomas D. Pfister, Yi Lu, and John H. Dawson

Bioinorganic Chemistry Special Feature: Neutral thiol as a proximal ligand to ferrous heme iron: Implications for heme proteins that lose cysteine thiolate ligation on reduction
PNAS 2003 100: 3641-3646; published online before print March 24 2003, 10.1073/pnas.0737142100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Christie L. Hunter, Robert Maurus, Marcia R. Mauk, Hung Lee, Emma L. Raven, Harry Tong, Nham Nguyen, Michael Smith, Gary D. Brayer, and A. Grant Mauk

Bioinorganic Chemistry Special Feature: Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin
PNAS 2003 100: 3647-3652; published online before print March 18 2003, 10.1073/pnas.0636702100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Xiaofeng Liu, Weili Jin, and Elizabeth C. Theil Bioinorganic Chemistry Special Feature: Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral PNAS 2003 100: 3653-3658; published online before print March 12 2003, 10.1073/pnas.0636928100 [Abstract] [Full Text] [PDF]

Suraj Dhungana, Céline H. Taboy, Damon S. Anderson, Kevin G. Vaughan, Philip Aisen, Timothy A. Mietzner, and Alvin L. Crumbliss

Bioinorganic Chemistry Special Feature: The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin
PNAS 2003 100: 3659-3664; published online before print March 19 2003, 10.1073/pnas.0536897100 [Abstract] [Full Text] [PDF]  

Mi Hee Lim, Jan-Uwe Rohde, Audria Stubna, Michael R. Bukowski, Miquel Costas, Raymond Y. N. Ho, Eckard Münck, Wonwoo Nam, and Lawrence Que, Jr.

Bioinorganic Chemistry Special Feature: An Fe^IV==O complex of a tetradentate tripodal nonheme ligand
PNAS 2003 100: 3665-3670; published online before print March 18 2003, 10.1073/pnas.0636830100 [Abstract] [Full Text] [PDF]  

Jason Shearer, Sarah B. Fitch, Werner Kaminsky, Jason Benedict, Robert C. Scarrow, and Julie A. Kovacs

Bioinorganic Chemistry Special Feature: How does cyanide inhibit superoxide reductase? Insight from synthetic Fe^IIIN₄S model complexes
PNAS 2003 100: 3671-3676; published online before print March 24 2003, 10.1073/pnas.0637029100 [Abstract] [Full Text] [PDF] [Supporting Information]  

K. Hantke, G. Nicholson, W. Rabsch, and G. Winkelmann

Bioinorganic Chemistry Special Feature: Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN
PNAS 2003 100: 3677-3682; published online before print March 24 2003, 10.1073/pnas.0737682100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Marcetta Y. Darensbourg, Erica J. Lyon, Xuan Zhao, and Irene P. Georgakaki

Bioinorganic Chemistry Special Feature: The organometallic active site of [Fe]hydrogenase: Models and entatic states
PNAS 2003 100: 3683-3688; published online before print March 17 2003, 10.1073/pnas.0536955100 [Abstract] [Full Text] [PDF]  

Javier Seravalli, Weiwei Gu, Annie Tam, Erick Strauss, Tadhg P. Begley, Stephen P. Cramer, and Stephen W. Ragsdale

Bioinorganic Chemistry Special Feature: Functional copper at the acetyl-CoA synthase active site
PNAS 2003 100: 3689-3694; published online before print February 14 2003, 10.1073/pnas.0436720100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Show-Jen Chiou, Charles G. Riordan, and Arnold L. Rheingold

Bioinorganic Chemistry Special Feature: Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates
PNAS 2003 100: 3695-3700; published online before print March 20 2003, 10.1073/pnas.0637221100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, and Peter J. Sadler

Bioinorganic Chemistry Special Feature: Interdomain zinc site on human albumin
PNAS 2003 100: 3701-3706; published online before print February 21 2003, 10.1073/pnas.0436576100 [Abstract] [Full Text] [PDF] [Supporting Figures] [Online Correction to Supporting Figure 8]  

Marcelino Maneiro, Wolfgang F. Ruettinger, Emilie Bourles, George L. McLendon, and G. Charles Dismukes

Bioinorganic Chemistry Special Feature: Kinetics of proton-coupled electron-transfer reactions to the manganese-oxo "cubane" complexes containing the Mn₄O and Mn₄O core types
PNAS 2003 100: 3707-3712; published online before print March 18 2003, 10.1073/pnas.0637229100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Mario A. Pennella, Jacob E. Shokes, Nathaniel J. Cosper, Robert A. Scott, and David P. Giedroc

Bioinorganic Chemistry Special Feature: Structural elements of metal selectivity in metal sensor proteins
PNAS 2003 100: 3713-3718; published online before print March 21 2003, 10.1073/pnas.0636943100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hemant K. Joshi, J. Jon A. Cooney, Frank E. Inscore, Nadine E. Gruhn, Dennis L. Lichtenberger, and John H. Enemark

Bioinorganic Chemistry Special Feature: Investigation of metal-dithiolate fold angle effects: Implications for molybdenum and tungsten enzymes
PNAS 2003 100: 3719-3724; published online before print March 24 2003, 10.1073/pnas.0636832100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Joel T. Welch, William R. Kearney, and Sonya J. Franklin

Bioinorganic Chemistry Special Feature: Lanthanide-binding helix-turn-helix peptides: Solution structure of a designed metallonuclease
PNAS 2003 100: 3725-3730; published online before print March 18 2003, 10.1073/pnas.0536562100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Eiichi Kimura, Shin Aoki, Emiko Kikuta, and Tohru Koike

Bioinorganic Chemistry Special Feature: A macrocyclic zinc(II) fluorophore as a detector of apoptosis
PNAS 2003 100: 3731-3736; published online before print March 19 2003, 10.1073/pnas.0637275100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Henrik Junicke, Jonathan R. Hart, Jennifer Kisko, Oleg Glebov, Ilan R. Kirsch, and Jacqueline K. Barton

Bioinorganic Chemistry Special Feature: A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition
PNAS 2003 100: 3737-3742; published online before print February 27 2003, 10.1073/pnas.0537194100 [Abstract] [Full Text] [PDF]  

Hong Guo and Thomas D. Tullius

Bioinorganic Chemistry Special Feature: Gapped DNA is anisotropically bent
PNAS 2003 100: 3743-3747; published online before print March 18 2003, 10.1073/pnas.0737062100 [Abstract] [Full Text] [PDF]  

Eva Freisinger, Irene B. Rother, Marc Sven Lüth, and Bernhard Lippert

Bioinorganic Chemistry Special Feature: Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a₂Pt^II: Artificial nucleobase quartets and CH...N bonds
PNAS 2003 100: 3748-3753; published online before print March 21 2003, 10.1073/pnas.0436700100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jennifer S. Martinez, Jayme N. Carter-Franklin, Elizabeth L. Mann, Jessica D. Martin, Margo G. Haygood, and Alison Butler

Bioinorganic Chemistry Special Feature: Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium
PNAS 2003 100: 3754-3759; published online before print March 21 2003, 10.1073/pnas.0637444100 [Abstract] [Full Text] [PDF]  

Brian T. Farrer and Vincent L. Pecoraro

Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis
PNAS 2003 100: 3760-3765; published online before print January 27 2003, 10.1073/pnas.0336055100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Dion D. D. Hepburn, Jiarong Xiao, Sharell Bindom, John B. Vincent, and Janis O'Donnell

Bioinorganic Chemistry Special Feature: Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster
PNAS 2003 100: 3766-3771; published online before print March 20 2003, 10.1073/pnas.0636646100 [Abstract] [Full Text] [PDF]  

Matthew L. Plenert and Jason B. Shear

Microsecond electrophoresis
PNAS 2003 100: 3853-3857; published online before print March 10 2003, 10.1073/pnas.0637211100 [Abstract] [Full Text] [PDF]  
See Commentary on page 3545

Engineering

Mathematics

Erik Christensen, Florin Pop, Allan M. Sinclair, and Roger R. Smith

Property factors and the Hochschild cohomology problem
PNAS 2003 100: 3865-3869; published online before print March 19 2003, 10.1073/pnas.0737489100 [Abstract] [Full Text] [PDF]  

Physics

Gregor Knöner, Klaus Reimann, Ralf Röwer, Ulf Södervall, and Hans-Eckhardt Schaefer

Enhanced oxygen diffusivity in interfaces of nanocrystalline ZrO₂·Y₂O₃
PNAS 2003 100: 3870-3873; published online before print March 24 2003, 10.1073/pnas.0730783100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Psychology

Peter Hagoort, Marlies Wassenaar, and Colin Brown

Real-time semantic compensation in patients with agrammatic comprehension: Electrophysiological evidence for multiple-route plasticity
PNAS 2003 100: 4340-4345; published online before print March 17 2003, 10.1073/pnas.0230613100 [Abstract] [Full Text] [PDF]  

Social Sciences

Lawrence M. Wein, David L. Craft, and Edward H. Kaplan

Emergency response to an anthrax attack
PNAS 2003 100: 4346-4351; published online before print March 21 2003, 10.1073/pnas.0636861100 [Abstract] [Full Text] [PDF] [Supporting Text]  
See Commentary on page 4355

BIOLOGICAL SCIENCES

Anthropology

Applied Biological Sciences

Junghae Suh, Denis Wirtz, and Justin Hanes

Efficient active transport of gene nanocarriers to the cell nucleus
PNAS 2003 100: 3878-3882; published online before print March 18 2003, 10.1073/pnas.0636277100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

J. Bernadette Moore, Raymond K. Blanchard, and Robert J. Cousins

Dietary zinc modulates gene expression in murine thymus: Results from a comprehensive differential display screening
PNAS 2003 100: 3883-3888; published online before print March 19 2003, 10.1073/pnas.0330670100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Biochemistry

Brian T. Farrer and Vincent L. Pecoraro

Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis
PNAS 2003 100: 3760-3765; published online before print January 27 2003, 10.1073/pnas.0336055100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ornella Maglio, Flavia Nastri, Vincenzo Pavone, Angela Lombardi, and William F. DeGrado

Bioinorganic Chemistry Special Feature: Preorganization of molecular binding sites in designed diiron proteins
PNAS 2003 100: 3772-3777; published online before print March 24 2003, 10.1073/pnas.0730771100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tatjana Kh. Shokhireva, Robert E. Berry, Elizabeth Uno, Celia A. Balfour, Hongjun Zhang, and F. Ann Walker

Bioinorganic Chemistry Special Feature: Electrochemical and NMR spectroscopic studies of distal pocket mutants of nitrophorin 2: Stability, structure, and dynamics of axial ligand complexes
PNAS 2003 100: 3778-3783; published online before print March 17 2003, 10.1073/pnas.0536641100 [Abstract] [Full Text] [PDF]  

Kevin H. Mitchell, Corina E. Rogge, Todd Gierahn, and Brian G. Fox

Bioinorganic Chemistry Special Feature: Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p-xylene
PNAS 2003 100: 3784-3789; published online before print March 14 2003, 10.1073/pnas.0636619100 [Abstract] [Full Text] [PDF]  

Matthew J. Ryle, Kevin D. Koehntop, Aimin Liu, Lawrence Que, Jr., and Robert P. Hausinger

Bioinorganic Chemistry Special Feature: Interconversion of two oxidized forms of taurine/-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding
PNAS 2003 100: 3790-3795; published online before print March 17 2003, 10.1073/pnas.0636740100 [Abstract] [Full Text] [PDF]  

Michael D. Clay, Christopher A. Cosper, Francis E. Jenney, Jr., Michael W. W. Adams, and Michael K. Johnson

Bioinorganic Chemistry Special Feature: Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase
PNAS 2003 100: 3796-3801; published online before print March 24 2003, 10.1073/pnas.0636858100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Joseph P. Emerson, Diane E. Cabelli, and Donald M. Kurtz, Jr.

Bioinorganic Chemistry Special Feature: An engineered two-iron superoxide reductase lacking the [Fe(SCys)₄] site retains its catalytic properties in vitro and in vivo
PNAS 2003 100: 3802-3807; published online before print March 13 2003, 10.1073/pnas.0537177100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Michelle M. Spiering, Dagmar Ringe, John R. Murphy, and Michael A. Marletta

Bioinorganic Chemistry Special Feature: Metal stoichiometry and functional studies of the diphtheria toxin repressor
PNAS 2003 100: 3808-3813; published online before print March 24 2003, 10.1073/pnas.0737977100 [Abstract] [Full Text] [PDF]  

Fabio Arnesano, Lucia Banci, Ivano Bertini, Stefano Mangani, and Andrew R. Thompsett

Bioinorganic Chemistry Special Feature: A redox switch in CopC: An intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites
PNAS 2003 100: 3814-3819; published online before print March 21 2003, 10.1073/pnas.0636904100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Raquel L. Lieberman, Deepak B. Shrestha, Peter E. Doan, Brian M. Hoffman, Timothy L. Stemmler, and Amy C. Rosenzweig

Bioinorganic Chemistry Special Feature: Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster
PNAS 2003 100: 3820-3825; published online before print March 12 2003, 10.1073/pnas.0536703100 [Abstract] [Full Text] [PDF]  

Derek T. Logan, Etienne Mulliez, Karl-Magnus Larsson, Sabrina Bodevin, Mohamed Atta, Pierre Emmanuel Garnaud, Britt-Marie Sjöberg, and Marc Fontecave

Bioinorganic Chemistry Special Feature: A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase
PNAS 2003 100: 3826-3831; published online before print March 24 2003, 10.1073/pnas.0736456100 [Abstract] [Full Text] [PDF]  

Yoav Arava, Yulei Wang, John D. Storey, Chih Long Liu, Patrick O. Brown, and Daniel Herschlag

Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae
PNAS 2003 100: 3889-3894; published online before print March 26 2003, 10.1073/pnas.0635171100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Sean J. Johnson, Jeffrey S. Taylor, and Lorena S. Beese

Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
PNAS 2003 100: 3895-3900; published online before print March 20 2003, 10.1073/pnas.0630532100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Richard J. S. Burchmore, Dayana Rodriguez-Contreras, Kathleen McBride, Michael P. Barrett, Govind Modi, David Sacks, and Scott M. Landfear

Genetic characterization of glucose transporter function in Leishmania mexicana
PNAS 2003 100: 3901-3906; published online before print March 21 2003, 10.1073/pnas.0630165100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Yong Yu, Lei Shi, and Arthur Karlin

Structural effects of quinacrine binding in the open channel of the acetylcholine receptor
PNAS 2003 100: 3907-3912; published online before print March 18 2003, 10.1073/pnas.0730718100 [Abstract] [Full Text] [PDF]  

Hari K. Bhat, Gloria Calaf, Tom K. Hei, Theresa Loya, and Jaydutt V. Vadgama

Critical role of oxidative stress in estrogen-induced carcinogenesis
PNAS 2003 100: 3913-3918; published online before print March 24 2003, 10.1073/pnas.0437929100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Gregory E. D. Mullen, Margaret N. Kennedy, Alberto Visintin, Alessandra Mazzoni, Cynthia A. Leifer, David R. Davies, and David M. Segal

The role of disulfide bonds in the assembly and function of MD-2
PNAS 2003 100: 3919-3924; published online before print March 17 2003, 10.1073/pnas.0630495100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Anna Lena Chabes, Cathie M. Pfleger, Marc W. Kirschner, and Lars Thelander

Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting complex-Cdh1-mediated proteolysis
PNAS 2003 100: 3925-3929; published online before print March 24 2003, 10.1073/pnas.0330774100 [Abstract] [Full Text] [PDF]  

Laura A. Cassiday and L. James Maher, III

Yeast genetic selections to optimize RNA decoys for transcription factor NF-B
PNAS 2003 100: 3930-3935; published online before print March 13 2003, 10.1073/pnas.0736013100 [Abstract] [Full Text] [PDF]  

Paula C. A. da Fonseca, Stephen A. Morris, Edmund P. Nerou, Colin W. Taylor, and Edward P. Morris

Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single-particle analysis
PNAS 2003 100: 3936-3941; published online before print March 21 2003, 10.1073/pnas.0536251100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Stefan Kammerer, Lora L. Burns-Hamuro, Yuliang Ma, Sara C. Hamon, Jaume M. Cànaves, Michael M. Shi, Matthew R. Nelson, Charles F. Sing, Charles R. Cantor, Susan S. Taylor, and Andreas Braun

Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism
PNAS 2003 100: 4066-4071; published online before print March 19 2003, 10.1073/pnas.2628028100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Lora L. Burns-Hamuro, Yuliang Ma, Stefan Kammerer, Ulrich Reineke, Chris Self, Charles Cook, Gary L. Olson, Charles R. Cantor, Andreas Braun, and Susan S. Taylor

Designing isoform-specific peptide disruptors of protein kinase A localization
PNAS 2003 100: 4072-4077; published online before print March 19 2003, 10.1073/pnas.2628038100 [Abstract] [Full Text] [PDF]  

Ronda Bransteitter, Phuong Pham, Matthew D. Scharff, and Myron F. Goodman

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
PNAS 2003 100: 4102-4107; published online before print March 21 2003, 10.1073/pnas.0730835100 [Abstract] [Full Text] [PDF]  

Biophysics

Mahantesh S. Navati, Uri Samuni, Philip Aisen, and Joel M. Friedman

Bioinorganic Chemistry Special Feature: Binding and release of iron by gel-encapsulated human transferrin: Evidence for a conformational search
PNAS 2003 100: 3832-3837; published online before print December 16 2002, 10.1073/pnas.262526399 [Abstract] [Full Text] [PDF]  

I-Jy Chang, Jennifer C. Lee, Jay R. Winkler, and Harry B. Gray

Bioinorganic Chemistry Special Feature: The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH₃)₅(His-33)-Zn-cytochrome c
PNAS 2003 100: 3838-3840; published online before print March 19 2003, 10.1073/pnas.0637283100 [Abstract] [Full Text] [PDF]  

Janna G. Kiselar, Paul A. Janmey, Steven C. Almo, and Mark R. Chance

Visualizing the Ca²⁺-dependent activation of gelsolin by using synchrotron footprinting
PNAS 2003 100: 3942-3947; published online before print March 24 2003, 10.1073/pnas.0736004100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Houbi Nguyen, Marcus Jäger, Alessandro Moretto, Martin Gruebele, and Jeffery W. Kelly

Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation
PNAS 2003 100: 3948-3953; published online before print March 21 2003, 10.1073/pnas.0538054100 [Abstract] [Full Text] [PDF]  
See Commentary on page 3555

John Karanicolas and Charles L. Brooks, III

The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: Lessons for protein design?
PNAS 2003 100: 3954-3959; published online before print March 24 2003, 10.1073/pnas.0731771100 [Abstract] [Full Text] [PDF]  
See Commentary on page 3555

Ido Braslavsky, Benedict Hebert, Emil Kartalov, and Stephen R. Quake

Sequence information can be obtained from single DNA molecules
PNAS 2003 100: 3960-3964; published online before print March 21 2003, 10.1073/pnas.0230489100 [Abstract] [Full Text] [PDF]  

Cell Biology

Yun Zhao, Dong-Hyun Hong, Basil Pawlyk, Guohua Yue, Michael Adamian, Marcin Grynberg, Adam Godzik, and Tiansen Li

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: Subserving RPGR function and participating in disk morphogenesis
PNAS 2003 100: 3965-3970; published online before print March 21 2003, 10.1073/pnas.0637349100 [Abstract] [Full Text] [PDF]  

Hiroyuki Sasaki, Chiyuki Matsui, Kyoko Furuse, Yuko Mimori-Kiyosue, Mikio Furuse, and Shoichiro Tsukita

Dynamic behavior of paired claudin strands within apposing plasma membranes
PNAS 2003 100: 3971-3976; published online before print March 21 2003, 10.1073/pnas.0630649100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Aurore Morlon and Paolo Sassone-Corsi

The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1
PNAS 2003 100: 3977-3982; published online before print March 18 2003, 10.1073/pnas.0735923100 [Abstract] [Full Text] [PDF]  

Muhammad Al-Hajj, Max S. Wicha, Adalberto Benito-Hernandez, Sean J. Morrison, and Michael F. Clarke From the Cover: Prospective identification of tumorigenic breast cancer cells PNAS 2003 100: 3983-3988; published online before print March 10 2003, 10.1073/pnas.0530291100 [Abstract] [Full Text] [PDF]   See Commentary on page 3547

Jong-Sun Kang, Jessica L. Feinleib, Sarah Knox, Michael A. Ketteringham, and Robert S. Krauss

Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation
PNAS 2003 100: 3989-3994; published online before print March 12 2003, 10.1073/pnas.0736565100 [Abstract] [Full Text] [PDF]  

Jun Guo, Markus R. Wenk, Lorenzo Pellegrini, Franco Onofri, Fabio Benfenati, and Pietro De Camilli

Phosphatidylinositol 4-kinase type II is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles
PNAS 2003 100: 3995-4000; published online before print March 19 2003, 10.1073/pnas.0230488100 [Abstract] [Full Text] [PDF]  

Bita Sahaf, Kartoosh Heydari, Leonard A. Herzenberg, and Leonore A. Herzenberg

Lymphocyte surface thiol levels
PNAS 2003 100: 4001-4005; published online before print March 17 2003, 10.1073/pnas.2628032100 [Abstract] [Full Text] [PDF]  

M. A. Lokuta, P. A. Nuzzi, and A. Huttenlocher

Calpain regulates neutrophil chemotaxis
PNAS 2003 100: 4006-4011; published online before print March 20 2003, 10.1073/pnas.0636533100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

James Rhee, Yusuke Inoue, J. Cliff Yoon, Pere Puigserver, Melina Fan, Frank J. Gonzalez, and Bruce M. Spiegelman

Regulation of hepatic fasting response by PPAR coactivator-1 (PGC-1): Requirement for hepatocyte nuclear factor 4 in gluconeogenesis
PNAS 2003 100: 4012-4017; published online before print March 21 2003, 10.1073/pnas.0730870100 [Abstract] [Full Text] [PDF]  

Developmental Biology

Timm Schroeder, Stuart T. Fraser, Minetaro Ogawa, Satomi Nishikawa, Chio Oka, Georg W. Bornkamm, Shin-Ichi Nishikawa, Tasuku Honjo, and Ursula Just

Recombination signal sequence-binding protein J alters mesodermal cell fate decisions by suppressing cardiomyogenesis
PNAS 2003 100: 4018-4023; published online before print March 24 2003, 10.1073/pnas.0438008100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lydia Michaut, Susanne Flister, Martin Neeb, Kevin P. White, Ulrich Certa, and Walter J. Gehring

Analysis of the eye developmental pathway in Drosophila using DNA microarrays
PNAS 2003 100: 4024-4029; published online before print March 24 2003, 10.1073/pnas.0630561100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kenta Sumiyama and Frank H. Ruddle

Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements
PNAS 2003 100: 4030-4034; published online before print March 17 2003, 10.1073/pnas.0530119100 [Abstract] [Full Text] [PDF]  

Ecology

Lennart Persson, André M. De Roos, David Claessen, Pär Byström, Johan Lövgren, Stefan Sjögren, Richard Svanbäck, Eva Wahlström, and Erika Westman

Gigantic cannibals driving a whole-lake trophic cascade
PNAS 2003 100: 4035-4039; published online before print March 19 2003, 10.1073/pnas.0636404100 [Abstract] [Full Text] [PDF]  

Marten Scheffer, Sándor Szabó, Alessandra Gragnani, Egbert H. van Nes, Sergio Rinaldi, Nils Kautsky, Jon Norberg, Rudi M. M. Roijackers, and Rob J. M. Franken

Floating plant dominance as a stable state
PNAS 2003 100: 4040-4045; published online before print March 12 2003, 10.1073/pnas.0737918100 [Abstract] [Full Text] [PDF]  

Craig R. White and Roger S. Seymour

Mammalian basal metabolic rate is proportional to body mass^2/3
PNAS 2003 100: 4046-4049; published online before print March 13 2003, 10.1073/pnas.0436428100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Evolution

F. Y. Hu, D. Y. Tao, E. Sacks, B. Y. Fu, P. Xu, J. Li, Y. Yang, K. McNally, G. S. Khush, A. H. Paterson, and Z.-K. Li

Convergent evolution of perenniality in rice and sorghum
PNAS 2003 100: 4050-4054; published online before print March 17 2003, 10.1073/pnas.0630531100 [Abstract] [Full Text] [PDF]  

Carrie-Ann Whittle and Mark O. Johnston

Male-biased transmission of deleterious mutations to the progeny in Arabidopsis thaliana
PNAS 2003 100: 4055-4059; published online before print March 24 2003, 10.1073/pnas.0730639100 [Abstract] [Full Text] [PDF]  

Kazuhiko Kawasaki and Kenneth M. Weiss

Mineralized tissue and vertebrate evolution: The secretory calcium-binding phosphoprotein gene cluster
PNAS 2003 100: 4060-4065; published online before print March 19 2003, 10.1073/pnas.0638023100 [Abstract] [Full Text] [PDF] [Supporting Figure]