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COMMENTARIES

Andrew G. Clark

A slippery boundary
PNAS 2003 100: 4971-4972; published online before print April 18 2003, 10.1073/pnas.0931310100 [Extract] [Full Text] [PDF]  
See companion article on page 5258

William M. Bonner

Low-dose radiation: Thresholds, bystander effects, and adaptive responses
PNAS 2003 100: 4973-4975; published online before print April 18 2003, 10.1073/pnas.1031538100 [Extract] [Full Text] [PDF]  
See companion article on page 5057

Julian I. Schroeder

Knockout of the guard cell K⁺out channel and stomatal movements
PNAS 2003 100: 4976-4977; published online before print April 18 2003, 10.1073/pnas.1031801100 [Extract] [Full Text] [PDF]  
See companion article on page 5549

Martin Feelisch

Nitroxyl gets to the heart of the matter
PNAS 2003 100: 4978-4980; published online before print April 18 2003, 10.1073/pnas.1031571100 [Extract] [Full Text] [PDF]  
See companion article on page 5537

Gilbert Di Paolo and Pietro De Camilli

Does clathrin pull the fission trigger?
PNAS 2003 100: 4981-4983; published online before print April 18 2003, 10.1073/pnas.0930650100 [Extract] [Full Text] [PDF]  
See companion article on page 5175

PHYSICAL SCIENCES

Applied Physical Sciences

Robert J. Chen, Sarunya Bangsaruntip, Katerina A. Drouvalakis, Nadine Wong Shi Kam, Moonsub Shim, Yiming Li, Woong Kim, Paul J. Utz, and Hongjie Dai

Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors
PNAS 2003 100: 4984-4989; published online before print April 15 2003, 10.1073/pnas.0837064100 [Abstract] [Full Text] [PDF]  

Chemistry

M. R. Armstrong, J. P. Ogilvie, M. L. Cowan, A. M. Nagy, and R. J. D. Miller

Observation of the cascaded atomic-to-global length scales driving protein motion
PNAS 2003 100: 4990-4994; published online before print April 15 2003, 10.1073/pnas.0936507100 [Abstract] [Full Text] [PDF]  

Niren Murthy, Mingcheng Xu, Stephany Schuck, Jun Kunisawa, Nilabh Shastri, and Jean M. J. Fréchet Inaugural Article by a Recently Elected Academy Member: Inaugural Article: A macromolecular delivery vehicle for protein-based vaccines: Acid-degradable protein-loaded microgels PNAS 2003 100: 4995-5000; published online before print April 18 2003, 10.1073/pnas.0930644100 [Abstract] [Full Text] [PDF] [Supporting Text]

Christian F. W. Becker, Christie L. Hunter, Ralf Seidel, Stephen B. H. Kent, Roger S. Goody, and Martin Engelhard

Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1
PNAS 2003 100: 5075-5080; published online before print April 18 2003, 10.1073/pnas.0831227100 [Abstract] [Full Text] [PDF]  

Physics

Lincoln Wolfenstein

Lessons from Kepler and the theory of everything
PNAS 2003 100: 5001-5003; published online before print April 17 2003, 10.1073/pnas.0931283100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Agricultural Sciences

Shai Morin, Robert W. Biggs, Mark S. Sisterson, Laura Shriver, Christa Ellers-Kirk, Dawn Higginson, Daniel Holley, Linda J. Gahan, David G. Heckel, Yves Carrière, Timothy J. Dennehy, Judith K. Brown, and Bruce E. Tabashnik

Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm
PNAS 2003 100: 5004-5009; published online before print April 14 2003, 10.1073/pnas.0831036100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Applied Biological Sciences

Céline Raynaud, Patricia Sarçabal, Isabelle Meynial-Salles, Christian Croux, and Philippe Soucaille

Molecular characterization of the 1,3-propanediol (1,3-PD) operon of Clostridium butyricum
PNAS 2003 100: 5010-5015; published online before print April 18 2003, 10.1073/pnas.0734105100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Michael J. Root and Dean H. Hamer

Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein
PNAS 2003 100: 5016-5021; published online before print April 17 2003, 10.1073/pnas.0936926100 [Abstract] [Full Text] [PDF]  

Byung-Kwon Choi, Piotr Bobrowicz, Robert C. Davidson, Stephen R. Hamilton, David H. Kung, Huijuan Li, Robert G. Miele, Juergen H. Nett, Stefan Wildt, and Tillman U. Gerngross

Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris
PNAS 2003 100: 5022-5027; published online before print April 17 2003, 10.1073/pnas.0931263100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Rebekah R. White, Siqing Shan, Christopher P. Rusconi, Geetha Shetty, Mark W. Dewhirst, Christopher D. Kontos, and Bruce A. Sullenger

Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2
PNAS 2003 100: 5028-5033; published online before print April 11 2003, 10.1073/pnas.0831159100 [Abstract] [Full Text] [PDF]  

Atsushi Suzuki, Hiromitsu Nakauchi, and Hideki Taniguchi

Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
PNAS 2003 100: 5034-5039; published online before print April 17 2003, 10.1073/pnas.0936260100 [Abstract] [Full Text] [PDF]  

Biochemistry

Michio Asahi, Yuji Sugita, Kazimierz Kurzydlowski, Stella De Leon, Michihiko Tada, Chikashi Toyoshima, and David H. MacLennan

Sarcolipin regulates sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban
PNAS 2003 100: 5040-5045; published online before print April 11 2003, 10.1073/pnas.0330962100 [Abstract] [Full Text] [PDF]  

George Hong and Kenneth N. Kreuzer

Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug-topoisomerase complexes
PNAS 2003 100: 5046-5051; published online before print April 18 2003, 10.1073/pnas.0835166100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Vitaly Epshtein, Alexander S. Mironov, and Evgeny Nudler

The riboswitch-mediated control of sulfur metabolism in bacteria
PNAS 2003 100: 5052-5056; published online before print April 17 2003, 10.1073/pnas.0531307100 [Abstract] [Full Text] [PDF]  

Kai Rothkamm and Markus Löbrich From the Cover: Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses PNAS 2003 100: 5057-5062; published online before print April 4 2003, 10.1073/pnas.0830918100 [Abstract] [Full Text] [PDF]   See Commentary on page 4973

Michael Engel, Torsten Hoffmann, Leona Wagner, Michael Wermann, Ulrich Heiser, Reiner Kiefersauer, Robert Huber, Wolfram Bode, Hans-Ulrich Demuth, and Hans Brandstetter

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
PNAS 2003 100: 5063-5068; published online before print April 10 2003, 10.1073/pnas.0230620100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Valérie Campanacci, Audrey Lartigue, B. Martin Hällberg, T. Alwyn Jones, Marie-Therèse Giudici-Orticoni, Mariella Tegoni, and Christian Cambillau

Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding
PNAS 2003 100: 5069-5074; published online before print April 15 2003, 10.1073/pnas.0836654100 [Abstract] [Full Text] [PDF]  

Christian F. W. Becker, Christie L. Hunter, Ralf Seidel, Stephen B. H. Kent, Roger S. Goody, and Martin Engelhard

Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1
PNAS 2003 100: 5075-5080; published online before print April 18 2003, 10.1073/pnas.0831227100 [Abstract] [Full Text] [PDF]  

Maria H. Hamilton, Lana A. Cook, Theodore R. McRackan, Kevin L. Schey, and John D. Hildebrandt

₂ subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate
PNAS 2003 100: 5081-5086; published online before print April 16 2003, 10.1073/pnas.0831228100 [Abstract] [Full Text] [PDF]  

Jerri Curtis, Geumsoo Kim, Nancy B. Wehr, and Rodney L. Levine

Group B streptococcal phospholipid causes pulmonary hypertension
PNAS 2003 100: 5087-5090; published online before print April 17 2003, 10.1073/pnas.0931493100 [Abstract] [Full Text] [PDF]  

Gregory L. Moore and Costas D. Maranas

Identifying residue-residue clashes in protein hybrids by using a second-order mean-field approach
PNAS 2003 100: 5091-5096; published online before print April 16 2003, 10.1073/pnas.0831190100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mohamed Ouhammouch, Robert E. Dewhurst, Winfried Hausner, Michael Thomm, and E. Peter Geiduschek

Activation of archaeal transcription by recruitment of the TATA-binding protein
PNAS 2003 100: 5097-5102; published online before print April 11 2003, 10.1073/pnas.0837150100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jun Wang, Ephrem Tekle, Hammou Oubrahim, John J. Mieyal, Earl R. Stadtman, and P. Boon Chock

Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin
PNAS 2003 100: 5103-5106; published online before print April 15 2003, 10.1073/pnas.0931345100 [Abstract] [Full Text] [PDF]  

Tsutomu Kabashima, Takumi Kawaguchi, Brian E. Wadzinski, and Kosaku Uyeda

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
PNAS 2003 100: 5107-5112; published online before print April 8 2003, 10.1073/pnas.0730817100 [Abstract] [Full Text] [PDF]  
See Commentary on page 5578

M. Todd Washington, William T. Wolfle, Thomas E. Spratt, Louise Prakash, and Satya Prakash

Yeast DNA polymerase makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate
PNAS 2003 100: 5113-5118; published online before print April 11 2003, 10.1073/pnas.0837578100 [Abstract] [Full Text] [PDF]  

Shlomit Chevion, Danny S. Moran, Yuval Heled, Yoav Shani, Gilad Regev, Benny Abbou, Eduard Berenshtein, Earl R. Stadtman, and Yoram Epstein

Plasma antioxidant status and cell injury after severe physical exercise
PNAS 2003 100: 5119-5123; published online before print April 17 2003, 10.1073/pnas.0831097100 [Abstract] [Full Text] [PDF]  

Mujib M. Rahman, Hiroshi Miyamoto, Henry Lardy, and Chawnshang Chang

Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells
PNAS 2003 100: 5124-5129; published online before print April 16 2003, 10.1073/pnas.0530097100 [Abstract] [Full Text] [PDF]  

Carolyn R. Hoyal, Abel Gutierrez, Brandon M. Young, Sergio D. Catz, Jun-Hsiang Lin, Philip N. Tsichlis, and Bernard M. Babior

Modulation of p47^PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase
PNAS 2003 100: 5130-5135; published online before print April 18 2003, 10.1073/pnas.1031526100 [Abstract] [Full Text] [PDF]  

Biophysics

Nicolas E. Buchler, Ulrich Gerland, and Terence Hwa

On schemes of combinatorial transcription logic
PNAS 2003 100: 5136-5141; published online before print April 17 2003, 10.1073/pnas.0930314100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Brian J. Bennion and Valerie Daggett

The molecular basis for the chemical denaturation of proteins by urea
PNAS 2003 100: 5142-5147; published online before print April 17 2003, 10.1073/pnas.0930122100 [Abstract] [Full Text] [PDF]  

Gennady M. Verkhivker, Djamal Bouzida, Daniel K. Gehlhaar, Paul A. Rejto, Stephan T. Freer, and Peter W. Rose

Simulating disorder-order transitions in molecular recognition of unstructured proteins: Where folding meets binding
PNAS 2003 100: 5148-5153; published online before print April 15 2003, 10.1073/pnas.0531373100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Jörg Gsponer, Urs Haberthür, and Amedeo Caflisch

The role of side-chain interactions in the early steps of aggregation: Molecular dynamics simulations of an amyloid-forming peptide from the yeast prion Sup35
PNAS 2003 100: 5154-5159; published online before print April 16 2003, 10.1073/pnas.0835307100 [Abstract] [Full Text] [PDF]  

Huamin Zhang, Genji Kurisu, Janet L. Smith, and William A. Cramer

A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b₆f complex of oxygenic photosynthesis
PNAS 2003 100: 5160-5163; published online before print April 17 2003, 10.1073/pnas.0931431100 [Abstract] [Full Text] [PDF]  

Cell Biology

Vikas K. Goel, Xuerong Li, Huiqing Chen, Shih-Chun Liu, Athar H. Chishti, and Steven S. Oh

Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes
PNAS 2003 100: 5164-5169; published online before print April 11 2003, 10.1073/pnas.0834959100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Heather M. Scobie, G. Jonah A. Rainey, Kenneth A. Bradley, and John A. T. Young

Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
PNAS 2003 100: 5170-5174; published online before print April 16 2003, 10.1073/pnas.0431098100 [Abstract] [Full Text] [PDF]  

T.-G. Iversen, G. Skretting, B. van Deurs, and K. Sandvig From the Cover: Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA PNAS 2003 100: 5175-5180; published online before print April 7 2003, 10.1073/pnas.0534231100 [Abstract] [Full Text] [PDF]   See Commentary on page 4981

Naoki Itano, Shu-ichi Okamoto, Dongxian Zhang, Stuart A. Lipton, and Erkki Ruoslahti

Cell spreading controls endoplasmic and nuclear calcium: A physical gene regulation pathway from the cell surface to the nucleus
PNAS 2003 100: 5181-5186; published online before print April 17 2003, 10.1073/pnas.0531397100 [Abstract] [Full Text] [PDF]  

Hervør L. Olsen, Marianne Høy, Wei Zhang, Alejandro M. Bertorello, Krister Bokvist, Kirsten Capito, Alexander M. Efanov, Björn Meister, Peter Thams, Shao-Nian Yang, Patrik Rorsman, Per-Olof Berggren, and Jesper Gromada

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic cells
PNAS 2003 100: 5187-5192; published online before print April 16 2003, 10.1073/pnas.0931282100 [Abstract] [Full Text] [PDF]  

Peter C. Gray, Craig A. Harrison, and Wylie Vale

Cripto forms a complex with activin and type II activin receptors and can block activin signaling
PNAS 2003 100: 5193-5198; published online before print April 7 2003, 10.1073/pnas.0531290100 [Abstract] [Full Text] [PDF]  

Carsten Lambert and Reinhild Prange

Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation
PNAS 2003 100: 5199-5204; published online before print April 15 2003, 10.1073/pnas.0930813100 [Abstract] [Full Text] [PDF]  

Hai Xiao, Tsai-Kun Li, Jin-Ming Yang, and Leroy F. Liu

Acidic pH induces topoisomerase II-mediated DNA damage
PNAS 2003 100: 5205-5210; published online before print April 11 2003, 10.1073/pnas.0935978100 [Abstract] [Full Text] [PDF]  

Robert A. Screaton, Stephan Kiessling, Owen J. Sansom, Catherine B. Millar, Kathryn Maddison, Adrian Bird, Alan R. Clarke, and Steven M. Frisch

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis
PNAS 2003 100: 5211-5216; published online before print April 17 2003, 10.1073/pnas.0431215100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Developmental Biology

Wenlin Yuan, Yi Rao, Randal P. Babiuk, John J. Greer, Jane Y. Wu, and David M. Ornitz

A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3
PNAS 2003 100: 5217-5222; published online before print April 17 2003, 10.1073/pnas.0730709100 [Abstract] [Full Text] [PDF]  

Parimal Majumder and Haini N. Cai

The functional analysis of insulator interactions in the Drosophila embryo
PNAS 2003 100: 5223-5228; published online before print April 16 2003, 10.1073/pnas.0830190100 [Abstract] [Full Text] [PDF]  

Elisabeth Dupin, Carla Real, Corinne Glavieux-Pardanaud, Pierre Vaigot, and Nicole M. Le Douarin

Reversal of developmental restrictions in neural crest lineages: Transition from Schwann cells to glial-melanocytic precursors in vitro
PNAS 2003 100: 5229-5233; published online before print April 17 2003, 10.1073/pnas.0831229100 [Abstract] [Full Text] [PDF]  

Shaolin Shi and Pamela Stanley

Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
PNAS 2003 100: 5234-5239; published online before print April 15 2003, 10.1073/pnas.0831126100 [Abstract] [Full Text] [PDF]  

Marta Kostrouchova, Zdenek Kostrouch, Vladimir Saudek, Joram Piatigorsky, and Joseph Edward Rall

BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development
PNAS 2003 100: 5240-5245; published online before print April 7 2003, 10.1073/pnas.0730770100 [Abstract] [Full Text] [PDF]  

Ecology

George Sugihara, Louis-Félix Bersier, T. Richard E. Southwood, Stuart L. Pimm, and Robert M. May

Predicted correspondence between species abundances and dendrograms of niche similarities
PNAS 2003 100: 5246-5251; published online before print April 17 2003, 10.1073/pnas.0831096100 [Abstract] [Full Text] [PDF]  

Evolution

R. Craig Albertson, J. Todd Streelman, and Thomas D. Kocher

Directional selection has shaped the oral jaws of Lake Malawi cichlid fishes
PNAS 2003 100: 5252-5257; published online before print April 18 2003, 10.1073/pnas.0930235100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mineyo Iwase, Yoko Satta, Yuriko Hirai, Hirohisa Hirai, Hirotami Imai, and Naoyuki Takahata From the Cover: The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species PNAS 2003 100: 5258-5263; published online before print April 2 2003, 10.1073/pnas.0635848100 [Abstract] [Full Text] [PDF] [Supporting Tables]   See Commentary on page 4971

Makoto Kato, Atsushi Takimura, and Atsushi Kawakita

An obligate pollination mutualism and reciprocal diversification in the tree genus Glochidion (Euphorbiaceae)
PNAS 2003 100: 5264-5267; published online before print April 14 2003, 10.1073/pnas.0837153100 [Abstract] [Full Text] [PDF]  

Michael W. Nachman, Hopi E. Hoekstra, and Susan L. D'Agostino

The genetic basis of adaptive melanism in pocket mice
PNAS 2003 100: 5268-5273; published online before print April 18 2003, 10.1073/pnas.0431157100 [Abstract] [Full Text] [PDF]  

Genetics

Nicolas E. Buchler, Ulrich Gerland, and Terence Hwa

On schemes of combinatorial transcription logic
PNAS 2003 100: 5136-5141; published online before print April 17 2003, 10.1073/pnas.0930314100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Casey L. Moulson, Daniel R. Martin, Jesse J. Lugus, Jean E. Schaffer, Anne C. Lind, and Jeffrey H. Miner

Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development
PNAS 2003 100: 5274-5279; published online before print April 15 2003, 10.1073/pnas.0431186100 [Abstract] [Full Text] [PDF]  

Brook Brouha, Joshua Schustak, Richard M. Badge, Sheila Lutz-Prigge, Alexander H. Farley, John V. Moran, and Haig H. Kazazian, Jr.

Hot L1s account for the bulk of retrotransposition in the human population
PNAS 2003 100: 5280-5285; published online before print April 7 2003, 10.1073/pnas.0831042100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Fangming Lin, Thomas Hiesberger, Kimberly Cordes, Angus M. Sinclair, Lawrence S. B. Goldstein, Stefan Somlo, and Peter Igarashi

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
PNAS 2003 100: 5286-5291; published online before print April 2 2003, 10.1073/pnas.0836980100 [Abstract] [Full Text] [PDF]  
See Commentary on page 5583

Graham N. Luke, L. Filipe C. Castro, Kirsten McLay, Christine Bird, Alan Coulson, and Peter W. H. Holland

Dispersal of NK homeobox gene clusters in amphioxus and humans
PNAS 2003 100: 5292-5295; published online before print April 18 2003, 10.1073/pnas.0836141100 [Abstract] [Full Text] [PDF]  

Richard Guyon, Travis D. Lorentzen, Christophe Hitte, Lisa Kim, Edouard Cadieu, Heidi G. Parker, Pascale Quignon, Jennifer K. Lowe, Corinne Renier, Boris Gelfenbeyn, Françoise Vignaux, Hawkins B. DeFrance, Stephanie Gloux, Gregory G. Mahairas, Catherine André, Francis Galibert, and Elaine A. Ostrander

A 1-Mb resolution radiation hybrid map of the canine genome
PNAS 2003 100: 5296-5301; published online before print April 16 2003, 10.1073/pnas.0831002100 [Abstract] [Full Text] [PDF]  

Daniel A. Barbash, Dominic F. Siino, Aaron M. Tarone, and John Roote

A rapidly evolving MYB-related protein causes species isolation in Drosophila
PNAS 2003 100: 5302-5307; published online before print April 14 2003, 10.1073/pnas.0836927100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hyeong C. Kim, Jian-guang Zhou, Helen R. Wilson, Grigoriy Mogilnitskiy, Donald L. Court, and Max E. Gottesman

Phage HK022 Nun protein represses translation of phage N (transcription termination/translation repression)
PNAS 2003 100: 5308-5312; published online before print April 8 2003, 10.1073/pnas.0430995100 [Abstract] [Full Text] [PDF]  

Timothy J. Haggerty, Karen I. Zeller, Rebecca C. Osthus, Diane R. Wonsey, and Chi V. Dang

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites
PNAS 2003 100: 5313-5318; published online before print April 17 2003, 10.1073/pnas.0931346100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Toshiaki Ara, Yuri Nakamura, Takeshi Egawa, Tatsuki Sugiyama, Kuniya Abe, Tadamitsu Kishimoto, Yasuhisa Matsui, and Takashi Nagasawa

Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)
PNAS 2003 100: 5319-5323; published online before print April 8 2003, 10.1073/pnas.0730719100 [Abstract] [Full Text] [PDF]  

Gobardhan Das, Mathew M. Augustine, Jyoti Das, Kim Bottomly, Prabir Ray, and Anuradha Ray

An important regulatory role for CD4⁺CD8 T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease
PNAS 2003 100: 5324-5329; published online before print April 14 2003, 10.1073/pnas.0831037100 [Abstract] [Full Text] [PDF]  

Anish Suri, James J. Walters, Osami Kanagawa, Michael L. Gross, and Emil R. Unanue

Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition
PNAS 2003 100: 5330-5335; published online before print April 7 2003, 10.1073/pnas.0330859100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

P'ng Loke and James P. Allison

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
PNAS 2003 100: 5336-5341; published online before print April 15 2003, 10.1073/pnas.0931259100 [Abstract] [Full Text] [PDF]  

Emanual Maverakis, Jonathan Beech, David B. Stevens, Akio Ametani, Laurent Brossay, Peter van den Elzen, Richard Mendoza, Quoc Thai, Luis H. Macias, Doug Ethell, Celia W. Campagnoni, Anthony T. Campagnoni, Alessandro Sette, and Eli E. Sercarz

Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC
PNAS 2003 100: 5342-5347; published online before print April 21 2003, 10.1073/pnas.0936151100 [Abstract] [Full Text] [PDF]  

Lara Myers, Chikara Takahashi, Robert S. Mittler, Robert J. Rossi, and Anthony T. Vella

Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering
PNAS 2003 100: 5348-5353; published online before print April 14 2003, 10.1073/pnas.0837611100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Christophe Viret, Xin He, and Charles A. Janeway, Jr.

Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection
PNAS 2003 100: 5354-5359; published online before print April 16 2003, 10.1073/pnas.0831129100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Medical Sciences

Laura Manuelidis and Zhi Yun Lu

Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease
PNAS 2003 100: 5360-5365; published online before print April 11 2003, 10.1073/pnas.0931192100 [Abstract] [Full Text] [PDF]  

Andrea E. Prota, Jacquelyn A. Campbell, Pierre Schelling, J. Craig Forrest, Melissa J. Watson, Timothy R. Peters, Michel Aurrand-Lions, Beat A. Imhof, Terence S. Dermody, and Thilo Stehle

Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding
PNAS 2003 100: 5366-5371; published online before print April 15 2003, 10.1073/pnas.0937718100 [Abstract] [Full Text] [PDF]  

Nicole Y. Fang, Timothy C. Greiner, Dennis D. Weisenburger, Wing C. Chan, Julie M. Vose, Lynette M. Smith, James O. Armitage, R. Aeryn Mayer, Brian L. Pike, Francis S. Collins, and Joseph G. Hacia

Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma
PNAS 2003 100: 5372-5377; published online before print April 15 2003, 10.1073/pnas.0831102100 [Abstract] [Full Text] [PDF]  

Hidemasa Oh, Sam C. Wang, Arun Prahash, Motoaki Sano, Christine S. Moravec, George E. Taffet, Lloyd H. Michael, Keith A. Youker, Mark L. Entman, and Michael D. Schneider

Telomere attrition and Chk2 activation in human heart failure
PNAS 2003 100: 5378-5383; published online before print April 17 2003, 10.1073/pnas.0836098100 [Abstract] [Full Text] [PDF]  

Harry Rubin

Cancer cachexia: Its correlations and causes
PNAS 2003 100: 5384-5389; published online before print April 17 2003, 10.1073/pnas.0931260100 [Abstract] [Full Text] [PDF]  

Ayelet M. Samuni, Eric Y. Chuang, Murali C. Krishna, William Stein, William DeGraff, Angelo Russo, and James B. Mitchell

Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: Chemoprevention strategies with antioxidants
PNAS 2003 100: 5390-5395; published online before print April 17 2003, 10.1073/pnas.0930078100 [Abstract] [Full Text] [PDF]  

Christoph Rader, Subhash C. Sinha, Mikhail Popkov, Richard A. Lerner, and Carlos F. Barbas, III

Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst
PNAS 2003 100: 5396-5400; published online before print April 17 2003, 10.1073/pnas.0931308100 [Abstract] [Full Text] [PDF]  

Donald C. Malins, Paul M. Johnson, Edward A. Barker, Nayak L. Polissar, Thomas M. Wheeler, and Katie M. Anderson

Cancer-related changes in prostate DNA as men age and early identification of metastasis in primary prostate tumors
PNAS 2003 100: 5401-5406; published online before print April 17 2003, 10.1073/pnas.0931396100 [Abstract] [Full Text] [PDF]  

Robin A. J. Smith, Carolyn M. Porteous, Alison M. Gane, and Michael P. Murphy

Delivery of bioactive molecules to mitochondria in vivo
PNAS 2003 100: 5407-5412; published online before print April 15 2003, 10.1073/pnas.0931245100 [Abstract] [Full Text] [PDF]  

M. P. Lutolf, J. L. Lauer-Fields, H. G. Schmoekel, A. T. Metters, F. E. Weber, G. B. Fields, and J. A. Hubbell

Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics
PNAS 2003 100: 5413-5418; published online before print April 9 2003, 10.1073/pnas.0737381100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Bryan A. Laffitte, Lily C. Chao, Jing Li, Robert Walczak, Sarah Hummasti, Sean B. Joseph, Antonio Castrillo, Damien C. Wilpitz, David J. Mangelsdorf, Jon L. Collins, Enrique Saez, and Peter Tontonoz

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
PNAS 2003 100: 5419-5424; published online before print April 15 2003, 10.1073/pnas.0830671100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Michael T. Spiotto, Michael A. Reth, and Hans Schreiber

Genetic changes occurring in established tumors rapidly stimulate new antibody responses
PNAS 2003 100: 5425-5430; published online before print April 17 2003, 10.1073/pnas.0930140100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Seiji Kondo, Ying Lu, Michael Debbas, Athena W. Lin, Ildiko Sarosi, Annick Itie, Andrew Wakeham, JoAnn Tuan, Chris Saris, Gary Elliott, Weili Ma, Samuel Benchimol, Scott W. Lowe, Tak Wah Mak, and Sushil K. Thukral

Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)
PNAS 2003 100: 5431-5436; published online before print April 17 2003, 10.1073/pnas.0530308100 [Abstract] [Full Text] [PDF]  

Microbiology

Rutilio A. Fratti, Jennifer Chua, Isabelle Vergne, and Vojo Deretic

Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest
PNAS 2003 100: 5437-5442; published online before print April 17 2003, 10.1073/pnas.0737613100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yinuo Li, Hong Sun, Xiaoyuan Ma, Ann Lu, Renate Lux, David Zusman, and Wenyuan Shi

Extracellular polysaccharides mediate pilus retraction during social motility of Myxococcus xanthus
PNAS 2003 100: 5443-5448; published online before print April 18 2003, 10.1073/pnas.0836639100 [Abstract] [Full Text] [PDF]  

Hanbin Mao, Paul S. Cremer, and Michael D. Manson

A sensitive, versatile microfluidic assay for bacterial chemotaxis
PNAS 2003 100: 5449-5454; published online before print April 18 2003, 10.1073/pnas.0931258100 [Abstract] [Full Text] [PDF]  

Rekha Seshadri, Ian T. Paulsen, Jonathan A. Eisen, Timothy D. Read, Karen E. Nelson, William C. Nelson, Naomi L. Ward, Hervé Tettelin, Tanja M. Davidsen, Maureen J. Beanan, Robert T. Deboy, Sean C. Daugherty, Lauren M. Brinkac, Ramana Madupu, Robert J. Dodson, Hoda M. Khouri, Kathy H. Lee, Heather A. Carty, David Scanlan, Robert A. Heinzen, Herbert A. Thompson, James E. Samuel, Claire M. Fraser, and John F. Heidelberg

Complete genome sequence of the Q-fever pathogen Coxiella burnetii
PNAS 2003 100: 5455-5460; published online before print April 18 2003, 10.1073/pnas.0931379100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Hiroshi Imamizu, Tomoe Kuroda, Satoru Miyauchi, Toshinori Yoshioka, and Mitsuo Kawato

Modular organization of internal models of tools in the human cerebellum
PNAS 2003 100: 5461-5466; published online before print April 18 2003, 10.1073/pnas.0835746100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Pieter R. Roelfsema, Paul S. Khayat, and Henk Spekreijse

Subtask sequencing in the primary visual cortex
PNAS 2003 100: 5467-5472; published online before print April 14 2003, 10.1073/pnas.0431051100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Peter Teismann, Kim Tieu, Dong-Kug Choi, Du-Chu Wu, Ali Naini, Stéphane Hunot, Miquel Vila, Vernice Jackson-Lewis, and Serge Przedborski

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
PNAS 2003 100: 5473-5478; published online before print April 17 2003, 10.1073/pnas.0837397100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Erbo Dong, Hector Caruncho, Wen Sheng Liu, Neil R. Smalheiser, Dennis R. Grayson, Erminio Costa, and Alessandro Guidotti

A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes
PNAS 2003 100: 5479-5484; published online before print April 21 2003, 10.1073/pnas.1031602100 [Abstract] [Full Text] [PDF]  

Svetlana Dzitoyeva, Nikola Dimitrijevic, and Hari Manev

-Aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: Adult RNA interference and pharmacological evidence
PNAS 2003 100: 5485-5490; published online before print April 11 2003, 10.1073/pnas.0830111100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Elva Díaz, Yee Hwa Yang, Todd Ferreira, Kenneth C. Loh, Yasushi Okazaki, Yoshihide Hayashizaki, Marc Tessier-Lavigne, Terence P. Speed, and John Ngai

Analysis of gene expression in the developing mouse retina
PNAS 2003 100: 5491-5496; published online before print April 17 2003, 10.1073/pnas.0831080100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Laurie Carr, Marco Iacoboni, Marie-Charlotte Dubeau, John C. Mazziotta, and Gian Luigi Lenzi

Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas
PNAS 2003 100: 5497-5502; published online before print April 7 2003, 10.1073/pnas.0935845100 [Abstract] [Full Text] [PDF]  

Nataa Savi, Andreas Lüthi, Beat H. Gähwiler, and R. Anne McKinney

N-methyl-D-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses
PNAS 2003 100: 5503-5508; published online before print April 17 2003, 10.1073/pnas.0831035100 [Abstract] [Full Text] [PDF]  

Haining Zhong, Jun Lai, and King-Wai Yau

Selective heteromeric assembly of cyclic nucleotide-gated channels
PNAS 2003 100: 5509-5513; published online before print April 16 2003, 10.1073/pnas.0931279100 [Abstract] [Full Text] [PDF]  

M. C. Göpfert and D. Robert

Motion generation by Drosophila mechanosensory neurons
PNAS 2003 100: 5514-5519; published online before print March 17 2003, 10.1073/pnas.0737564100 [Abstract] [Full Text] [PDF]  
See Commentary on page 5581

Gerald M. Edelman

Naturalizing consciousness: A theoretical framework
PNAS 2003 100: 5520-5524; published online before print April 17 2003, 10.1073/pnas.0931349100 [Abstract] [Full Text] [PDF]  

Pharmacology

Alan S. Kopin, Edward W. McBride, Ci Chen, Roger M. Freidinger, Duan Chen, Chun-Mei Zhao, and Martin Beinborn

Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation
PNAS 2003 100: 5525-5530; published online before print April 15 2003, 10.1073/pnas.0831223100 [Abstract] [Full Text] [PDF]  

Giuseppe Cirino, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca, Ada Popolo, Alessandro Palmieri, Ciro Imbimbo, Ferdinando Fusco, Nicola Longo, Gianfranco Tajana, Louis J. Ignarro, and Vincenzo Mirone

Involvement of ₃-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function
PNAS 2003 100: 5531-5536; published online before print April 21 2003, 10.1073/pnas.0931347100 [Abstract] [Full Text] [PDF]  

Nazareno Paolocci, Tatsuo Katori, Hunter C. Champion, Marcus E. St. John, Katrina M. Miranda, Jon M. Fukuto, David A. Wink, and David A. Kass From the Cover: Positive inotropic and lusitropic effects of HNO/NO in failing hearts: Independence from -adrenergic signaling PNAS 2003 100: 5537-5542; published online before print April 18 2003, 10.1073/pnas.0937302100 [Abstract] [Full Text] [PDF]   See Commentary on page 4978

Physiology