Cover illustration
November 25, 2003; 100 (Suppl 2)
Cover image: Cone snails belong to a genus containing 500 species of predatory snails. These snails produce small, highly structured, venomous proteins for capturing prey and combating predators. Active toxins contain a modified amino acid, γ-carboxyglutamate, as well as specific disulfide linkages. Proper folding of these small peptides requires the expression of protein disulfide isomerases to facilitate the incorporation of several disulfide bonds. See the article by Bulaj et al. on pages 14562–14568.
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