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COMMENTARIES

Yaakov Levy and José N. Onuchic

Water and proteins: A love–hate relationship
PNAS 2004 101: 3325-3326; published online before print March 1 2004, 10.1073/pnas.0400157101 [Extract] [Full Text] [PDF]  
See companion article on page 3352

PHYSICAL SCIENCES

Applied Physical Sciences

Stephan Thiberge, Amotz Nechushtan, David Sprinzak, Opher Gileadi, Vered Behar, Ory Zik, Yehuda Chowers, Shulamit Michaeli, Joseph Schlessinger, and Elisha Moses

Scanning electron microscopy of cells and tissues under fully hydrated conditions
PNAS 2004 101: 3346-3351; published online before print February 26 2004, 10.1073/pnas.0400088101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Chemistry

Lei Zheng, Ulrich Baumann, and Jean-Louis Reymond

Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9
PNAS 2004 101: 3387-3392; published online before print February 26 2004, 10.1073/pnas.0400263101 [Abstract] [Full Text] [PDF]  

Physics

Joanna Aizenberg, Vikram C. Sundar, Andrew D. Yablon, James C. Weaver, and Gang Chen

Biological glass fibers: Correlation between optical and structural properties
PNAS 2004 101: 3358-3363; published online before print March 1 2004, 10.1073/pnas.0307843101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Economic Sciences

Douglas A. Hibbs, Jr. and Ola Olsson

Geography, biogeography, and why some countries are rich and others are poor
PNAS 2004 101: 3715-3720; published online before print February 25 2004, 10.1073/pnas.0305531101 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Stephan Thiberge, Amotz Nechushtan, David Sprinzak, Opher Gileadi, Vered Behar, Ory Zik, Yehuda Chowers, Shulamit Michaeli, Joseph Schlessinger, and Elisha Moses

Scanning electron microscopy of cells and tissues under fully hydrated conditions
PNAS 2004 101: 3346-3351; published online before print February 26 2004, 10.1073/pnas.0400088101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Biochemistry

Masao Fujinaga, Maia M. Cherney, Hiroshi Oyama, Kohei Oda, and Michael N. G. James

The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum
PNAS 2004 101: 3364-3369; published online before print March 1 2004, 10.1073/pnas.0400246101 [Abstract] [Full Text] [PDF]  

Magnus Hallberg, Gennady V. Polozkov, Guo-Zhen Hu, Jenny Beve, Claes M. Gustafsson, Hans Ronne, and Stefan Björklund

Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-µm plasmid
PNAS 2004 101: 3370-3375; published online before print February 26 2004, 10.1073/pnas.0400221101 [Abstract] [Full Text] [PDF]  

Fabienne Paumet, Vahid Rahimian, and James E. Rothman

The specificity of SNARE-dependent fusion is encoded in the SNARE motif
PNAS 2004 101: 3376-3380; published online before print February 23 2004, 10.1073/pnas.0400271101 [Abstract] [Full Text] [PDF]  

Jung H. Suh, Swapna V. Shenvi, Brian M. Dixon, Honglei Liu, Anil K. Jaiswal, Rui-Ming Liu, and Tory M. Hagen

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
PNAS 2004 101: 3381-3386; published online before print February 25 2004, 10.1073/pnas.0400282101 [Abstract] [Full Text] [PDF]  

Lei Zheng, Ulrich Baumann, and Jean-Louis Reymond

Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9
PNAS 2004 101: 3387-3392; published online before print February 26 2004, 10.1073/pnas.0400263101 [Abstract] [Full Text] [PDF]  

Irwin A. Rose and Todd M. Weaver

The role of the allosteric B site in the fumarase reaction
PNAS 2004 101: 3393-3397; published online before print February 27 2004, 10.1073/pnas.0307524101 [Abstract] [Full Text] [PDF]  

Shuang Deng, Richard A. Stein, and N. Patrick Higgins

Transcription-induced barriers to supercoil diffusion in the Salmonella typhimurium chromosome
PNAS 2004 101: 3398-3403; published online before print March 1 2004, 10.1073/pnas.0307550101 [Abstract] [Full Text] [PDF] [Supporting Information]  

John F. Cipollo, Antoine Awad, Catherine E. Costello, Phillips W. Robbins, and Carlos B. Hirschberg

Biosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharides
PNAS 2004 101: 3404-3408; published online before print March 1 2004, 10.1073/pnas.0400384101 [Abstract] [Full Text] [PDF]  

Biophysics

Judith Klein-Seetharaman, Naveena V. K. Yanamala, Fathima Javeed, Philip J. Reeves, Elena V. Getmanova, Michele C. Loewen, Harald Schwalbe, and H. Gobind Khorana

Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR
PNAS 2004 101: 3409-3413; published online before print February 27 2004, 10.1073/pnas.0308713101 [Abstract] [Full Text] [PDF]  

Lixin Ma, Christopher T. Jones, Teresa D. Groesch, Richard J. Kuhn, and Carol Beth Post

Solution structure of dengue virus capsid protein reveals another fold
PNAS 2004 101: 3414-3419; published online before print March 1 2004, 10.1073/pnas.0305892101 [Abstract] [Full Text] [PDF]  

Fumimasa Nomura, Takehiko Inaba, Satoshi Ishikawa, Miki Nagata, Sho Takahashi, Hirokazu Hotani, and Kingo Takiguchi

Microscopic observations reveal that fusogenic peptides induce liposome shrinkage prior to membrane fusion
PNAS 2004 101: 3420-3425; published online before print February 26 2004, 10.1073/pnas.0304660101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Neil P. Johnson, Walter A. Baase, and Peter H. von Hippel

Low-energy circular dichroism of 2-aminopurine dinucleotide as a probe of local conformation of DNA and RNA
PNAS 2004 101: 3426-3431; published online before print March 1 2004, 10.1073/pnas.0400591101 [Abstract] [Full Text] [PDF]  

John Karanicolas and Charles L. Brooks, III

Integrating folding kinetics and protein function: Biphasic kinetics and dual binding specificity in a WW domain
PNAS 2004 101: 3432-3437; published online before print February 23 2004, 10.1073/pnas.0304825101 [Abstract] [Full Text] [PDF]  

Cell Biology

Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L. Hurley, Lee A. Witters, Ronald A. DePinho, and Lewis C. Cantley Inaugural Article by a Recently Elected Academy Member: Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress PNAS 2004 101: 3329-3335; published online before print February 25 2004, 10.1073/pnas.0308061100 [Abstract] [Full Text] [PDF] [Supporting Figures]

Kenna R. Mills, Mauricio Reginato, Jayanta Debnath, Bridget Queenan, and Joan S. Brugge

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
PNAS 2004 101: 3438-3443; published online before print March 1 2004, 10.1073/pnas.0400443101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lisa M. Klumpp, Andreas Hoenger, and Susan P. Gilbert

Kinesin's second step
PNAS 2004 101: 3444-3449; published online before print February 25 2004, 10.1073/pnas.0307691101 [Abstract] [Full Text] [PDF]  

Eric J. Smart, Robert A. De Rose, and Steven A. Farber

Annexin 2–caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport
PNAS 2004 101: 3450-3455; published online before print February 25 2004, 10.1073/pnas.0400441101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Qihong Huang, Angel Raya, Paul DeJesus, Sheng-Hao Chao, Kim C. Quon, Jeremy S. Caldwell, Sumit K. Chanda, Juan C. Izpisua-Belmonte, and Peter G. Schultz

Identification of p53 regulators by genome-wide functional analysis
PNAS 2004 101: 3456-3461; published online before print February 27 2004, 10.1073/pnas.0308562100 [Abstract] [Full Text] [PDF]  

Motohiro Homma, Daisuke Shiomi, Michio Homma, and Ikuro Kawagishi

Attractant binding alters arrangement of chemoreceptor dimers within its cluster at a cell pole
PNAS 2004 101: 3462-3467; published online before print March 1 2004, 10.1073/pnas.0306660101 [Abstract] [Full Text] [PDF]  

Amandine Vanhoutteghem and Philippe Djian

Basonuclin 2: An extremely conserved homolog of the zinc finger protein basonuclin
PNAS 2004 101: 3468-3473; published online before print February 26 2004, 10.1073/pnas.0400268101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Developmental Biology

Michael T. Tetzlaff, Wei Yu, Mamie Li, Pumin Zhang, Milton Finegold, Kathleen Mahon, J. Wade Harper, Robert J. Schwartz, and Stephen J. Elledge Inaugural Article by a Recently Elected Academy Member: Inaugural Article, From The Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein PNAS 2004 101: 3338-3345; published online before print February 6 2004, 10.1073/pnas.0307875101 [Abstract] [Full Text] [PDF]

Lily Ng, Richard J. Goodyear, Chad A. Woods, Mark J. Schneider, Edward Diamond, Guy P. Richardson, Matthew W. Kelley, Donald L. St. Germain, Valerie Anne Galton, and Douglas Forrest

Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase
PNAS 2004 101: 3474-3479; published online before print March 1 2004, 10.1073/pnas.0307402101 [Abstract] [Full Text] [PDF]  

Evolution

Swaine L. Chen, William Lee, Alison K. Hottes, Lucy Shapiro, and Harley H. McAdams

Codon usage between genomes is constrained by genome-wide mutational processes
PNAS 2004 101: 3480-3485; published online before print February 27 2004, 10.1073/pnas.0307827100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Joel D. Parker, Karen M. Parker, Barbara H. Sohal, Rajindar S. Sohal, and Laurent Keller

Decreased expression of Cu–Zn superoxide dismutase 1 in ants with extreme lifespan
PNAS 2004 101: 3486-3489; published online before print March 1 2004, 10.1073/pnas.0400222101 [Abstract] [Full Text] [PDF]  

Andres Aguilar, Gary Roemer, Sally Debenham, Matthew Binns, David Garcelon, and Robert K. Wayne

High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal
PNAS 2004 101: 3490-3494; published online before print February 27 2004, 10.1073/pnas.0306582101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yang Liu, Mark Gerstein, and Donald M. Engelman

Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism
PNAS 2004 101: 3495-3497; published online before print March 1 2004, 10.1073/pnas.0307330101 [Abstract] [Full Text] [PDF]  

Genetics

The U.S.-Venezuela Collaborative Research Project, Nancy S. Wexler, Judith Lorimer, Julie Porter, Fidela Gomez, Carol Moskowitz, Edith Shackell, Karen Marder, Graciela Penchaszadeh, Simone A. Roberts, Javier Gayán, Denise Brocklebank, Stacey S. Cherny, Lon R. Cardon, Jacqueline Gray, Stephen R. Dlouhy, Sandra Wiktorski, Marion E. Hodes, P. Michael Conneally, Jack B. Penney, James Gusella, Jang-Ho Cha, Michael Irizarry, Diana Rosas, Steven Hersch, Zane Hollingsworth, Marcy MacDonald, Anne B. Young, J. Michael Andresen, David E. Housman, Margot Mieja de Young, Ernesto Bonilla, Theresa Stillings, Americo Negrette, S. Robert Snodgrass, Maria Dolores Martinez-Jaurrieta, Maria A. Ramos-Arroyo, Jacqueline Bickham, Juan Sanchez Ramos, Frederick Marshall, Ira Shoulson, Gustavo J. Rey, Andrew Feigin, Norman Arnheim, Amarilis Acevedo-Cruz, Leticia Acosta, Jose Alvir, Kenneth Fischbeck, Leslie M. Thompson, Angela Young, Leon Dure, Christopher J. O'Brien, Jane Paulsen, Adam Brickman, Denise Krch, Shelley Peery, Penelope Hogarth, Donald S. Higgins, Jr., and Bernhard Landwehrmeyer

Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
PNAS 2004 101: 3498-3503; published online before print March 1 2004, 10.1073/pnas.0308679101 [Abstract] [Full Text] [PDF]  

Timothy W. Hefferon, Joshua D. Groman, Catherine E. Yurk, and Garry R. Cutting

A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing
PNAS 2004 101: 3504-3509; published online before print March 1 2004, 10.1073/pnas.0400182101 [Abstract] [Full Text] [PDF]  

Giusy Fiucci, Séverine Beaucourt, Dominique Duflaut, Alexandra Lespagnol, Pamela Stumptner-Cuvelette, Anne Géant, Gilles Buchwalter, Marcel Tuynder, Laurent Susini, Jean-Michel Lassalle, Christine Wasylyk, Bohdan Wasylyk, Moshe Oren, Robert Amson, and Adam Telerman

Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter
PNAS 2004 101: 3510-3515; published online before print February 25 2004, 10.1073/pnas.0400177101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Immunology

Koichi Tabeta, Philippe Georgel, Edith Janssen, Xin Du, Kasper Hoebe, Karine Crozat, Suzanne Mudd, Louis Shamel, Sosathya Sovath, Jason Goode, Lena Alexopoulou, Richard A. Flavell, and Bruce Beutler

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
PNAS 2004 101: 3516-3521; published online before print March 1 2004, 10.1073/pnas.0400525101 [Abstract] [Full Text] [PDF]  

Cecilia Garlanda, Federica Riva, Nadia Polentarutti, Chiara Buracchi, Marina Sironi, Maida De Bortoli, Marta Muzio, Raffaella Bergottini, Eugenio Scanziani, Annunciata Vecchi, Emilio Hirsch, and Alberto Mantovani

Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family
PNAS 2004 101: 3522-3526; published online before print March 1 2004, 10.1073/pnas.0308680101 [Abstract] [Full Text] [PDF]  

James R. Carlyle, Amanda M. Jamieson, Stephan Gasser, Christopher S. Clingan, Hisashi Arase, and David H. Raulet

Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors
PNAS 2004 101: 3527-3532; published online before print February 27 2004, 10.1073/pnas.0308304101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Zhengfan Jiang, Tak W. Mak, Ganes Sen, and Xiaoxia Li

Toll-like receptor 3-mediated activation of NF-B and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-
PNAS 2004 101: 3533-3538; published online before print February 24 2004, 10.1073/pnas.0308496101 [Abstract] [Full Text] [PDF]  

Ana Cauerhff, Fernando A. Goldbaum, and Bradford C. Braden

Structural mechanism for affinity maturation of an anti-lysozyme antibody
PNAS 2004 101: 3539-3544; published online before print February 26 2004, 10.1073/pnas.0400060101 [Abstract] [Full Text] [PDF]  

Stephen J. Turner, Nicole L. La Gruta, John Stambas, Gabriela Diaz, and Peter C. Doherty

Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8⁺ effector T cells
PNAS 2004 101: 3545-3550; published online before print March 1 2004, 10.1073/pnas.0307347101 [Abstract] [Full Text] [PDF]  

Micah T. McClain, Carol S. Lutz, Kenneth M. Kaufman, Ofer Z. Faig, Timothy F. Gross, and Judith A. James

Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response
PNAS 2004 101: 3551-3556; published online before print February 26 2004, 10.1073/pnas.0306267101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Muriel Asheuer, Françoise Pflumio, Sonia Benhamida, Anne Dubart-Kupperschmitt, Françoise Fouquet, Yoshinori Imai, Patrick Aubourg, and Nathalie Cartier

Human CD34⁺ cells differentiate into microglia and express recombinant therapeutic protein
PNAS 2004 101: 3557-3562; published online before print February 27 2004, 10.1073/pnas.0306431101 [Abstract] [Full Text] [PDF]  

Takahiro Watanabe, Hirofumi Jono, Jiahuai Han, David J. Lim, and Jian-Dong Li

Synergistic activation of NF-B by nontypeable Haemophilus influenzae and tumor necrosis factor
PNAS 2004 101: 3563-3568; published online before print March 1 2004, 10.1073/pnas.0400557101 [Abstract] [Full Text] [PDF]  

Tsuyoshi Mikkaichi, Takehiro Suzuki, Tohru Onogawa, Masayuki Tanemoto, Hiroya Mizutamari, Masahiro Okada, Tatsuji Chaki, Satohiro Masuda, Taro Tokui, Nobuaki Eto, Michiaki Abe, Fumitoshi Satoh, Michiaki Unno, Takanori Hishinuma, Ken-ichi Inui, Sadayoshi Ito, Junichi Goto, and Takaaki Abe

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney
PNAS 2004 101: 3569-3574; published online before print March 1 2004, 10.1073/pnas.0304987101 [Abstract] [Full Text] [PDF]  

Shuang-Yuan Kuang, Peta E. Jackson, Jin-Bing Wang, Pei-Xing Lu, Alvaro Muñoz, Geng-Sun Qian, Thomas W. Kensler, and John D. Groopman

Specific mutations of hepatitis B virus in plasma predict liver cancer development
PNAS 2004 101: 3575-3580; published online before print February 27 2004, 10.1073/pnas.0308232100 [Abstract] [Full Text] [PDF]  

Estanislao Bachrach, Sheng Li, Antonio L. Perez, Jaclyn Schienda, Kalliopi Liadaki, Jay Volinski, Alan Flint, Jeffrey Chamberlain, and Louis M. Kunkel

Systemic delivery of human microdystrophin to regenerating mouse dystrophic muscle by muscle progenitor cells
PNAS 2004 101: 3581-3586; published online before print March 1 2004, 10.1073/pnas.0400373101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Carlene K. Chun, Egon A. Ozer, Michael J. Welsh, Joseph Zabner, and E. P. Greenberg From The Cover: Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia PNAS 2004 101: 3587-3590; published online before print February 17 2004, 10.1073/pnas.0308750101 [Abstract] [Full Text] [PDF]

Microbiology

Jesse D. Woodson and Jorge C. Escalante-Semerena

CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B₁₂ precursor cobinamide in archaea
PNAS 2004 101: 3591-3596; published online before print February 27 2004, 10.1073/pnas.0305939101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Wanyin Deng, José L. Puente, Samantha Gruenheid, Yuling Li, Bruce A. Vallance, Alejandra Vázquez, Jeannette Barba, J. Antonio Ibarra, Paul O'Donnell, Pavel Metalnikov, Keith Ashman, Sansan Lee, David Goode, Tony Pawson, and B. Brett Finlay

Dissecting virulence: Systematic and functional analyses of a pathogenicity island
PNAS 2004 101: 3597-3602; published online before print February 26 2004, 10.1073/pnas.0400326101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Audrey Esclatine, Brunella Taddeo, Linton Evans, and Bernard Roizman

The herpes simplex virus 1 U_L41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific
PNAS 2004 101: 3603-3608; published online before print March 1 2004, 10.1073/pnas.0400354101 [Abstract] [Full Text] [PDF]  

Neuroscience

Erika S. Piedras-Rentería, Jason L. Pyle, Max Diehn, Lindsey L. Glickfeld, Nobutoshi C. Harata, Yuqing Cao, Ege T. Kavalali, Patrick O. Brown, and Richard W. Tsien

Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca²⁺ entry pathway
PNAS 2004 101: 3609-3614; published online before print February 27 2004, 10.1073/pnas.0308188100 [Abstract] [Full Text] [PDF]  

V. Menon, J. Leroux, C. D. White, and A. L. Reiss

Frontostriatal deficits in fragile X syndrome: Relation to FMR1 gene expression
PNAS 2004 101: 3615-3620; published online before print March 1 2004, 10.1073/pnas.0304544101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

John A. Wemmie, Matthew W. Coryell, Candice C. Askwith, Ejvis Lamani, A. Soren Leonard, Curt D. Sigmund, and Michael J. Welsh

Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior
PNAS 2004 101: 3621-3626; published online before print February 26 2004, 10.1073/pnas.0308753101 [Abstract] [Full Text] [PDF]  

Sergei Musatov, Jill Roberts, Andrew I. Brooks, John Pena, Simone Betchen, Donald W. Pfaff, and Michael G. Kaplitt

Inhibition of neuronal phenotype by PTEN in PC12 cells
PNAS 2004 101: 3627-3631; published online before print February 27 2004, 10.1073/pnas.0308289101 [Abstract] [Full Text] [PDF]  

Rena Li, Kristina Lindholm, Li-Bang Yang, Xu Yue, Martin Citron, Riqiang Yan, Thomas Beach, Lucia Sue, Marwan Sabbagh, Huaibin Cai, Philip Wong, Donald Price, and Yong Shen

Amyloid peptide load is correlated with increased -secretase activity in sporadic Alzheimer's disease patients
PNAS 2004 101: 3632-3637; published online before print February 20 2004, 10.1073/pnas.0205689101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

James A. Simmons, Nicola Neretti, Nathan Intrator, Richard A. Altes, Michael J. Ferragamo, and Mark I. Sanderson

Delay accuracy in bat sonar is related to the reciprocal of normalized echo bandwidth, or Q
PNAS 2004 101: 3638-3643; published online before print February 27 2004, 10.1073/pnas.0308279101 [Abstract] [Full Text] [PDF]  

Lucy Anderson, Daniela Rossi, Jackie Linehan, Sebastian Brandner, and Charles Weissmann

Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment
PNAS 2004 101: 3644-3649; published online before print March 8 2004, 10.1073/pnas.0308681101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Taku Nagai, Kiyofumi Yamada, Masako Yoshimura, Kazuhiro Ishikawa, Yoshiaki Miyamoto, Kazuki Hashimoto, Yukihiro Noda, Atsumi Nitta, and Toshitaka Nabeshima From The Cover: The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release PNAS 2004 101: 3650-3655; published online before print February 26 2004, 10.1073/pnas.0306587101 [Abstract] [Full Text] [PDF] [Supporting Figures]

Naveen T. Agnihotri, Robert D. Hawkins, Eric R. Kandel, and Clifford Kentros

The long-term stability of new hippocampal place fields requires new protein synthesis
PNAS 2004 101: 3656-3661; published online before print February 25 2004, 10.1073/pnas.0400385101 [Abstract] [Full Text] [PDF]  

Valerie B. Caraiscos, Erin M. Elliott, Kong E. You-Ten, Victor Y. Cheng, Delia Belelli, J. Glen Newell, Michael F. Jackson, Jeremy J. Lambert, Thomas W. Rosahl, Keith A. Wafford, John F. MacDonald, and Beverley A. Orser

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by 5 subunit-containing -aminobutyric acid type A receptors
PNAS 2004 101: 3662-3667; published online before print March 1 2004, 10.1073/pnas.0307231101 [Abstract] [Full Text] [PDF]  

Pharmacology

David Bishop-Bailey, Desmond T. Walsh, and Timothy D. Warner

Expression and activation of the farnesoid X receptor in the vasculature
PNAS 2004 101: 3668-3673; published online before print February 27 2004, 10.1073/pnas.0400046101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

C. Kopp, U. Rudolph, K. Löw, and I. Tobler

Modulation of rhythmic brain activity by diazepam: GABA_Areceptor subtype and state specificity
PNAS 2004 101: 3674-3679; published online before print February 27 2004, 10.1073/pnas.0306975101 [Abstract] [Full Text] [PDF]  

Daniela Sachs, Fernando Q. Cunha, and Sérgio H. Ferreira

Peripheral analgesic blockade of hypernociception: Activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K⁺ channel pathway
PNAS 2004 101: 3680-3685; published online before print February 27 2004, 10.1073/pnas.0308382101 [Abstract] [Full Text] [PDF]  

Physiology

Toshinobu Tokumoto, Mika Tokumoto, Ryo Horiguchi, Katsutoshi Ishikawa, and Yoshitaka Nagahama

Diethylstilbestrol induces fish oocyte maturation
PNAS 2004 101: 3686-3690; published online before print February 27 2004, 10.1073/pnas.0400072101 [Abstract] [Full Text] [PDF]  

Horst Fischer, Christian Schwarzer, and Beate Illek

Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel
PNAS 2004 101: 3691-3696; published online before print March 1 2004, 10.1073/pnas.0308393100 [Abstract] [Full Text] [PDF]  

Tracy L. Bale, Masahiko Hoshijima, Yusu Gu, Nancy Dalton, Keith R. Anderson, Kuo-Fen Lee, Jean Rivier, Kenneth R. Chien, Wylie W. Vale, and Kirk L. Peterson

The cardiovascular physiologic actions of urocortin II: Acute effects in murine heart failure
PNAS 2004 101: 3697-3702; published online before print February 27 2004, 10.1073/pnas.0307324101 [Abstract] [Full Text] [PDF]  

Plant Biology

Darren M. Crayn, Klaus Winter, and J. Andrew C. Smith

Multiple origins of crassulacean acid metabolism and the epiphytic habit in the Neotropical family Bromeliaceae
PNAS 2004 101: 3703-3708; published online before print February 24 2004, 10.1073/pnas.0400366101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Population Biology

David L. Smith, Jonathan Dushoff, Eli N. Perencevich, Anthony D. Harris, and Simon A. Levin

Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problem
PNAS 2004 101: 3709-3714; published online before print February 25 2004, 10.1073/pnas.0400456101 [Abstract] [Full Text] [PDF]