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COMMENTARIES

J. Woodland Hastings

Bacterial quorum-sensing signals are inactivated by mammalian cells
PNAS 2004 101: 3993-3994; published online before print March 15 2004, 10.1073/pnas.0400874101 [Extract] [Full Text] [PDF]  

James U. Bowie

Membrane proteins: A new method enters the fold
PNAS 2004 101: 3995-3996; published online before print March 15 2004, 10.1073/pnas.0400671101 [Extract] [Full Text] [PDF]  
See companion article on page 4065

Michael W. Deem

Evolution and evolvability of proteins in the laboratory
PNAS 2004 101: 3997-3998; published online before print March 15 2004, 10.1073/pnas.0400475101 [Extract] [Full Text] [PDF]  
See companion article on page 4142

PERSPECTIVES

Charles A. Holt and Alvin E. Roth

The Nash equilibrium: A perspective
PNAS 2004 101: 3999-4002; published online before print March 15 2004, 10.1073/pnas.0308738101 [Abstract] [Full Text] [PDF]  

Rafael Radi

Nitric oxide, oxidants, and protein tyrosine nitration
PNAS 2004 101: 4003-4008; published online before print March 12 2004, 10.1073/pnas.0307446101 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

Physics

B. Edwards and N. W. Ashcroft

Order in dense hydrogen at low temperatures
PNAS 2004 101: 4013-4018; published online before print March 17 2004, 10.1073/pnas.0307331101 [Abstract] [Full Text] [PDF]  

Davide Iannuzzi, Mariangela Lisanti, and Federico Capasso

Effect of hydrogen-switchable mirrors on the Casimir force
PNAS 2004 101: 4019-4023; published online before print March 15 2004, 10.1073/pnas.0400876101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Tom D. Dillehay and Alan L. Kolata

Long-term human response to uncertain environmental conditions in the Andes
PNAS 2004 101: 4325-4330; published online before print March 15 2004, 10.1073/pnas.0400538101 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

C. Helvig, J. F. Koener, G. C. Unnithan, and R. Feyereisen

CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata
PNAS 2004 101: 4024-4029; published online before print March 15 2004, 10.1073/pnas.0306980101 [Abstract] [Full Text] [PDF]  

Biochemistry

Brian A. Van Tine, Luan D. Dao, Shwu-Yuan Wu, Timothy M. Sonbuchner, Biing Yuan Lin, Nianxiang Zou, Cheng-Ming Chiang, Thomas R. Broker, and Louise T. Chow

Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning
PNAS 2004 101: 4030-4035; published online before print March 12 2004, 10.1073/pnas.0306848101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chi-Yong Eom, Won Do Heo, Madeleine L. Craske, Tobias Meyer, and I. Robert Lehman

The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection
PNAS 2004 101: 4036-4040; published online before print March 9 2004, 10.1073/pnas.0400738101 [Abstract] [Full Text] [PDF]  

Kalyan Das, Thomas Acton, Yiwen Chiang, Lydia Shih, Eddy Arnold, and Gaetano T. Montelione

Crystal structure of RlmA^I: Implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site
PNAS 2004 101: 4041-4046; published online before print March 3 2004, 10.1073/pnas.0400189101 [Abstract] [Full Text] [PDF]  

Chih-Cheng Tsai, Hung-Ying Kao, Akifumi Mitzutani, Ester Banayo, Harini Rajan, Michael McKeown, and Ronald M. Evans

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors
PNAS 2004 101: 4047-4052; published online before print March 11 2004, 10.1073/pnas.0400615101 [Abstract] [Full Text] [PDF]  

Akihiko Komuro, Yutaka Masuda, Koichi Kobayashi, Roger Babbitt, Murat Gunel, Richard A. Flavell, and Vincent T. Marchesi

The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells
PNAS 2004 101: 4053-4058; published online before print March 8 2004, 10.1073/pnas.0308619101 [Abstract] [Full Text] [PDF]  

Peng Fang, Christina C. Spevak, Cheng Wu, and Matthew S. Sachs

A nascent polypeptide domain that can regulate translation elongation
PNAS 2004 101: 4059-4064; published online before print March 12 2004, 10.1073/pnas.0400554101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Biophysics

Paul Wiggins and Rob Phillips

Analytic models for mechanotransduction: Gating a mechanosensitive channel
PNAS 2004 101: 4071-4076; published online before print March 15 2004, 10.1073/pnas.0307804101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Christopher D. Snow, Linlin Qiu, Deguo Du, Feng Gai, Stephen J. Hagen, and Vijay S. Pande

Trp zipper folding kinetics by molecular dynamics and temperature-jump spectroscopy
PNAS 2004 101: 4077-4082; published online before print March 12 2004, 10.1073/pnas.0305260101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kakoli Mitra, Iban Ubarretxena-Belandia, Tomohiko Taguchi, Graham Warren, and Donald M. Engelman

Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol
PNAS 2004 101: 4083-4088; published online before print March 11 2004, 10.1073/pnas.0307332101 [Abstract] [Full Text] [PDF]  

Tara N. Niraula, Takashi Konno, Hua Li, Hiroaki Yamada, Kazuyuki Akasaka, and Hideki Tachibana

Pressure-dissociable reversible assembly of intrinsically denatured lysozyme is a precursor for amyloid fibrils
PNAS 2004 101: 4089-4093; published online before print March 11 2004, 10.1073/pnas.0305798101 [Abstract] [Full Text] [PDF]  

Olga Vinogradova, Julia Vaynberg, Xiangming Kong, Thomas A. Haas, Edward F. Plow, and Jun Qin

Membrane-mediated structural transitions at the cytoplasmic face during integrin activation
PNAS 2004 101: 4094-4099; published online before print March 15 2004, 10.1073/pnas.0400742101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Cell Biology

Frank Boellmann, Toumy Guettouche, Yongle Guo, Mary Fenna, Laila Mnayer, and Richard Voellmy

DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity
PNAS 2004 101: 4100-4105; published online before print March 11 2004, 10.1073/pnas.0304768101 [Abstract] [Full Text] [PDF]  

Daniela Vallone, Srinivas Babu Gondi, David Whitmore, and Nicholas S. Foulkes

E-box function in a period gene repressed by light
PNAS 2004 101: 4106-4111; published online before print March 15 2004, 10.1073/pnas.0305436101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Jacob B. Hansen, Claus Jørgensen, Rasmus K. Petersen, Philip Hallenborg, Rita De Matteis, Hans A. Bøye, Natasa Petrovic, Sven Enerbäck, Jan Nedergaard, Saverio Cinti, Hein te Riele, and Karsten Kristiansen

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation
PNAS 2004 101: 4112-4117; published online before print March 15 2004, 10.1073/pnas.0301964101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Maria A. Ferraiuolo, Chung-Sheng Lee, Lian Wee Ler, Jeanne L. Hsu, Mauro Costa-Mattioli, Ming-Juan Luo, Robin Reed, and Nahum Sonenberg

A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay
PNAS 2004 101: 4118-4123; published online before print March 15 2004, 10.1073/pnas.0400933101 [Abstract] [Full Text] [PDF]  

Krisada Sakchaisri, Satoshi Asano, Li-Rong Yu, Mark J. Shulewitz, Chong J. Park, Jung-Eun Park, Young-Wook Cho, Timothy D. Veenstra, Jeremy Thorner, and Kyung S. Lee

Coupling morphogenesis to mitotic entry
PNAS 2004 101: 4124-4129; published online before print March 22 2004, 10.1073/pnas.0400641101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shao-Hua Yang, Ran Liu, Evelyn J. Perez, Yi Wen, Stanley M. Stevens, Jr., Thomas Valencia, Anne-Marie Brun-Zinkernagel, Laszlo Prokai, Yvonne Will, James Dykens, Peter Koulen, and James W. Simpkins

Mitochondrial localization of estrogen receptor
PNAS 2004 101: 4130-4135; published online before print March 15 2004, 10.1073/pnas.0306948101 [Abstract] [Full Text] [PDF]  

Ecology

Gregory J. McCabe, Michael A. Palecki, and Julio L. Betancourt

Pacific and Atlantic Ocean influences on multidecadal drought frequency in the United States
PNAS 2004 101: 4136-4141; published online before print March 11 2004, 10.1073/pnas.0306738101 [Abstract] [Full Text] [PDF]  

Evolution

John D. Lewis, Núria Saperas, Yue Song, Maria Jose Zamora, Manel Chiva, and Juan Ausió

Histone H1 and the origin of protamines
PNAS 2004 101: 4148-4152; published online before print March 15 2004, 10.1073/pnas.0308721101 [Abstract] [Full Text] [PDF]  

Genetics

Reeta Prusty, Paula Grisafi, and Gerald R. Fink

The plant hormone indoleacetic acid induces invasive growth in Saccharomyces cerevisiae
PNAS 2004 101: 4153-4157; published online before print March 9 2004, 10.1073/pnas.0400659101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Bob Y. Liu, Sean P. McDermott, Shariq S. Khwaja, and Caroline M. Alexander

The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells
PNAS 2004 101: 4158-4163; published online before print March 12 2004, 10.1073/pnas.0400699101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Jean-Philippe Brunet, Pablo Tamayo, Todd R. Golub, and Jill P. Mesirov

Metagenes and molecular pattern discovery using matrix factorization
PNAS 2004 101: 4164-4169; published online before print March 11 2004, 10.1073/pnas.0308531101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Eishou Matsuda, Toshiaki Shigeoka, Ryuji Iida, Shinya Yamanaka, Masashi Kawaichi, and Yasumasa Ishida

Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis
PNAS 2004 101: 4170-4174; published online before print March 9 2004, 10.1073/pnas.0400604101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Immunology

Chu-Young Kim, Hanne Quarsten, Elin Bergseng, Chaitan Khosla, and Ludvig M. Sollid

Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
PNAS 2004 101: 4175-4179; published online before print March 12 2004, 10.1073/pnas.0306885101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Annalise M. Martin, David Nolan, Silvana Gaudieri, Coral Ann Almeida, Richard Nolan, Ian James, Filipa Carvalho, Elizabeth Phillips, Frank T. Christiansen, Anthony W. Purcell, James McCluskey, and Simon Mallal

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant
PNAS 2004 101: 4180-4185; published online before print March 15 2004, 10.1073/pnas.0307067101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Theresa L. Gioannini, Athmane Teghanemt, DeSheng Zhang, Nathan P. Coussens, Wendie Dockstader, S. Ramaswamy, and Jerrold P. Weiss

Isolation of an endotoxin–MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
PNAS 2004 101: 4186-4191; published online before print March 9 2004, 10.1073/pnas.0306906101 [Abstract] [Full Text] [PDF]  

Masako Kohyama, Daisuke Sugahara, Shigeru Sugiyama, Hideo Yagita, Ko Okumura, and Nobumichi Hozumi

Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen
PNAS 2004 101: 4192-4197; published online before print March 10 2004, 10.1073/pnas.0400214101 [Abstract] [Full Text] [PDF] [SupportingFigures]  

Medical Sciences

Nicolas Genoud, Axel Behrens, Gino Miele, Dimitri Robay, Frank L. Heppner, Stefan Freigang, and Adriano Aguzzi

Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions
PNAS 2004 101: 4198-4203; published online before print March 8 2004, 10.1073/pnas.0400131101 [Abstract] [Full Text] [PDF]  

David N. Levy, Grace M. Aldrovandi, Olaf Kutsch, and George M. Shaw From The Cover: Dynamics of HIV-1 recombination in its natural target cells PNAS 2004 101: 4204-4209; published online before print March 9 2004, 10.1073/pnas.0306764101 [Abstract] [Full Text] [PDF] [Supporting Information]

Keith Del Villar and Carol A. Miller

Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons
PNAS 2004 101: 4210-4215; published online before print March 8 2004, 10.1073/pnas.0307349101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Bari Murtuza, Ken Suzuki, George Bou-Gharios, Jonathan R. Beauchamp, Ryszard T. Smolenski, Terence A. Partridge, and Magdi H. Yacoub

Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium
PNAS 2004 101: 4216-4221; published online before print March 12 2004, 10.1073/pnas.0306205101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Anindita Bhoumik, Nic Jones, and Ze'ev Ronai

Transcriptional switch by activating transcription factor 2-derived peptide sensitizes melanoma cells to apoptosis and inhibits their tumorigenicity
PNAS 2004 101: 4222-4227; published online before print March 9 2004, 10.1073/pnas.0400195101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Berent J. Prakken, Rodrigo Samodal, Tho D. Le, Francesca Giannoni, Gisella Puga Yung, John Scavulli, Diane Amox, Sarah Roord, Isme de Kleer, Dustan Bonnin, Paola Lanza, Charles Berry, Margherita Massa, Rosario Billetta, and Salvatore Albani

Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
PNAS 2004 101: 4228-4233; published online before print March 15 2004, 10.1073/pnas.0400061101 [Abstract] [Full Text] [PDF]  

Ivo Baric, Ksenija Fumic, Byron Glenn, Mario Cuk, Andreas Schulze, James D. Finkelstein, S. Jill James, Vlatka Mejaski-Bosnjak, Leo Pazanin, Igor P. Pogribny, Marko Rados, Vladimir Sarnavka, Mira Scukanec-Spoljar, Robert H. Allen, Sally Stabler, Lidija Uzelac, Oliver Vugrek, Conrad Wagner, Steven Zeisel, and S. Harvey Mudd

S-adenosylhomocysteine hydrolase deficiency in a human: A genetic disorder of methionine metabolism
PNAS 2004 101: 4234-4239; published online before print March 15 2004, 10.1073/pnas.0400658101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Graham Simmons, Jacqueline D. Reeves, Andrew J. Rennekamp, Sean M. Amberg, Andrew J. Piefer, and Paul Bates

Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
PNAS 2004 101: 4240-4245; published online before print March 9 2004, 10.1073/pnas.0306446101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Crystal M. Lauriano, Jeffrey R. Barker, Sang-Sun Yoon, Francis E. Nano, Bernard P. Arulanandam, Daniel J. Hassett, and Karl E. Klose

MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival
PNAS 2004 101: 4246-4249; published online before print March 9 2004, 10.1073/pnas.0307690101 [Abstract] [Full Text] [PDF]  

Zhiheng Pei, Edmund J. Bini, Liying Yang, Meisheng Zhou, Fritz Francois, and Martin J. Blaser

Bacterial biota in the human distal esophagus
PNAS 2004 101: 4250-4255; published online before print March 11 2004, 10.1073/pnas.0306398101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Oleg A. Igoshin, Roy Welch, Dale Kaiser, and George Oster

Waves and aggregation patterns in myxobacteria
PNAS 2004 101: 4256-4261; published online before print March 12 2004, 10.1073/pnas.0400704101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Keigo Machida, Kevin T.-N. Cheng, Vicky M.-H. Sung, Shigetaka Shimodaira, Karen L. Lindsay, Alexandra M. Levine, Ming-Yang Lai, and Michael M. C. Lai

Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes
PNAS 2004 101: 4262-4267; published online before print March 3 2004, 10.1073/pnas.0303971101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Claudia Groh, Jürgen Tautz, and Wolfgang Rössler

Synaptic organization in the adult honey bee brain is influenced by brood-temperature control during pupal development
PNAS 2004 101: 4268-4273; published online before print March 15 2004, 10.1073/pnas.0400773101 [Abstract] [Full Text] [PDF]  

Dan Levy, Moshe Jakubowski, and Rami Burstein

Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT_1B/1D receptor agonists
PNAS 2004 101: 4274-4279; published online before print March 11 2004, 10.1073/pnas.0306147101 [Abstract] [Full Text] [PDF]  

Karl Ebner, Nadia M. Rupniak, Alois Saria, and Nicolas Singewald

Substance P in the medial amygdala: Emotional stress-sensitive release and modulation of anxiety-related behavior in rats
PNAS 2004 101: 4280-4285; published online before print March 15 2004, 10.1073/pnas.0400794101 [Abstract] [Full Text] [PDF]  

John-Dylan Haynes, R. Beau Lotto, and Geraint Rees

Responses of human visual cortex to uniform surfaces
PNAS 2004 101: 4286-4291; published online before print March 9 2004, 10.1073/pnas.0307948101 [Abstract] [Full Text] [PDF]  

Christopher M. Bocchiaro and Jack L. Feldman From The Cover: Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons PNAS 2004 101: 4292-4295; published online before print March 15 2004, 10.1073/pnas.0305712101 [Abstract] [Full Text] [PDF]

Hua-tai Xu, Xiao-bing Yuan, Chen-bing Guan, Shumin Duan, Chien-ping Wu, and Linyin Feng

Calcium signaling in chemorepellant Slit2-dependent regulation of neuronal migration
PNAS 2004 101: 4296-4301; published online before print March 12 2004, 10.1073/pnas.0303893101 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Physiology

Qing Liu, Utta Berchner-Pfannschmidt, Ulrike Möller, Martina Brecht, Christoph Wotzlaw, Helmut Acker, Kurt Jungermann, and Thomas Kietzmann

A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression
PNAS 2004 101: 4302-4307; published online before print March 9 2004, 10.1073/pnas.0400265101 [Abstract] [Full Text] [PDF]  

Nathan S. Bryan, Tienush Rassaf, Ronald E. Maloney, Cynthia M. Rodriguez, Fumito Saijo, Juan R. Rodriguez, and Martin Feelisch

Cellular targets and mechanisms of nitros(yl)ation: An insight into their nature and kinetics in vivo
PNAS 2004 101: 4308-4313; published online before print March 10 2004, 10.1073/pnas.0306706101 [Abstract] [Full Text] [PDF]  

Dervis A. M. Salih, Gyanendra Tripathi, Cathy Holding, Tadge A. M. Szestak, M. Ivelisse Gonzalez, Emma J. Carter, Laura J. Cobb, Joan E. Eisemann, and Jennifer M. Pell

Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice
PNAS 2004 101: 4314-4319; published online before print March 9 2004, 10.1073/pnas.0400230101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Plant Biology

Kosaku Takahashi, Koji Kasai, and Kozo Ochi

Identification of the bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in plants
PNAS 2004 101: 4320-4324; published online before print March 9 2004, 10.1073/pnas.0308555101 [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for Alyanakian et al., Diversity of regulatory CD4^+T cells controlling distinct organ-specific autoimmune diseases, PNAS 2003 100:15806-15811 [Extract] [Full Text] [PDF]  

Correction for Power, Slow-wave sleep, acetylcholine, and memory consolidation, PNAS 2004 101:1795-1796 [Extract] [Full Text] [PDF]  

Correction for Zambrowicz et al., Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention, PNAS 2003 100:14109-14114 [Extract] [Full Text] [PDF]