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Table of Contents

April 13, 2004; 101 (15)  [Index By Author]  [Cover Photo]

FROM THE COVER

Single enantiomer synthesis of bioactive alkaloid precursor

Enzymatically synthesized interfering RNA

Designing redox-active hemoproteins

Tubulin modification and nuclear oscillation

Abrogating arrhythmias by calcium cycling

Asymmetric Catalysis Special Feature Part I

EDITORIAL

COMMENTARIES

PERSPECTIVES

PHYSICAL SCIENCES
    Chemistry

SOCIAL SCIENCES
    Anthropology

BIOLOGICAL SCIENCES
    Biochemistry
    Biophysics
    Cell Biology
    Evolution

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Physiology
    Plant Biology
    Psychology

CORRECTIONS

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EDITORIAL

Jack Halpern and Barry M. Trost
Asymmetric Catalysis Special Feature Part I: Asymmetric Catalysis
PNAS 2004 101: 5347. [Extract] [Full Text] [PDF]  

COMMENTARIES

Nicholas C. Spitzer
Coincidence detection enhances appropriate wiring of the nervous system
PNAS 2004 101: 5311-5312; published online before print April 5 2004, 10.1073/pnas.0401270101 [Extract] [Full Text] [PDF]  

Oded Singer, Amiel Yanai, and Inder M. Verma
Silence of the genes
PNAS 2004 101: 5313-5314; published online before print April 5 2004, 10.1073/pnas.0401209101 [Extract] [Full Text] [PDF]  
See companion article on page 5494

PERSPECTIVES

Barry M. Trost
Asymmetric Catalysis Special Feature Part I: Asymmetric catalysis: An enabling science
PNAS 2004 101: 5348-5355; published online before print February 27 2004, 10.1073/pnas.0306715101 [Abstract] [Full Text] [PDF]  

Ryoji Noyori, Masato Kitamura, and Takeshi Ohkuma
Asymmetric Catalysis Special Feature Part I: Toward efficient asymmetric hydrogenation: Architectural and functional engineering of chiral molecular catalysts
PNAS 2004 101: 5356-5362; published online before print March 19 2004, 10.1073/pnas.0307928100 [Abstract] [Full Text] [PDF]  

Christopher J. Douglas and Larry E. Overman
Asymmetric Catalysis Special Feature Part I: Catalytic asymmetric synthesis of all-carbon quaternary stereocenters
PNAS 2004 101: 5363-5367; published online before print January 14 2004, 10.1073/pnas.0307113101 [Abstract] [Full Text] [PDF]  

Mark S. Taylor and Eric N. Jacobsen
Asymmetric Catalysis Special Feature Part I: Asymmetric catalysis in complex target synthesis
PNAS 2004 101: 5368-5373; published online before print March 12 2004, 10.1073/pnas.0307893101 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Chemistry

Norie Momiyama, Hiromi Torii, Susumu Saito, and Hisashi Yamamoto
Asymmetric Catalysis Special Feature Part I: O-nitroso aldol synthesis: Catalytic enantioselective route to {alpha}-aminooxy carbonyl compounds via enamine intermediate
PNAS 2004 101: 5374-5378; published online before print April 5 2004, 10.1073/pnas.0307785101 [Abstract] [Full Text] [PDF] [Supporting Information]  

David L. Hughes, Guy C. Lloyd-Jones, Shane W. Krska, Laure Gouriou, Veronique D. Bonnet, Kevin Jack, Yongkui Sun, David J. Mathre, and Robert A. Reamer
Asymmetric Catalysis Special Feature Part I: Mechanistic studies of the molybdenum-catalyzed asymmetric alkylation reaction
PNAS 2004 101: 5379-5384; published online before print March 31 2004, 10.1073/pnas.0306918101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Ilya D. Gridnev, Masaya Yasutake, Tsuneo Imamoto, and Irina P. Beletskaya
Asymmetric Catalysis Special Feature Part I: Asymmetric hydrogenation of {alpha},{beta}-unsaturated phosphonates with Rh-BisP* and Rh-MiniPHOS catalysts: Scope and mechanism of the reaction
PNAS 2004 101: 5385-5390; published online before print March 15 2004, 10.1073/pnas.0306993101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Michael P. Doyle, Marcela Valenzuela, and Penglin Huang
Asymmetric Catalysis Special Feature Part I: Asymmetric hetero-Diels–Alder reaction catalyzed by dirhodium(II) carboxamidates
PNAS 2004 101: 5391-5395; published online before print April 1 2004, 10.1073/pnas.0307025101 [Abstract] [Full Text] [PDF]  

Natasha Cheeseman, Martin Fox, Mark Jackson, Ian C. Lennon, and Graham Meek
Asymmetric Catalysis Special Feature Part I: An efficient, palladium-catalyzed, enantioselective synthesis of (2R)-3-butene-1,2-diol and its use in highly selective Heck reactions
PNAS 2004 101: 5396-5399; published online before print February 11 2004, 10.1073/pnas.0307047101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Kristina Hallman, Anders Frölander, Tebikie Wondimagegn, Mats Svensson, and Christina Moberg
Asymmetric Catalysis Special Feature Part I: OH–Pd(0) interaction as a stabilizing factor in palladium-catalyzed allylic alkylations
PNAS 2004 101: 5400-5404; published online before print April 5 2004, 10.1073/pnas.0307084101 [Abstract] [Full Text] [PDF]  

Alexandre Côté, Alessandro A. Boezio, and André B. Charette
Asymmetric Catalysis Special Feature Part I: Catalytic asymmetric addition of diorganozinc reagents to N-phosphinoylalkylimines
PNAS 2004 101: 5405-5410; published online before print April 2 2004, 10.1073/pnas.0307096101 [Abstract] [Full Text] [PDF]  

Zihao Hua, Victor C. Vassar, Hojae Choi, and Iwao Ojima
Asymmetric Catalysis Special Feature Part I: New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations
PNAS 2004 101: 5411-5416; published online before print March 12 2004, 10.1073/pnas.0307101101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Ge Gao, Ru-Gang Xie, and Lin Pu
Asymmetric Catalysis Special Feature Part I: Highly enantioselective alkyne additions to aldehydes in the presence of 1,1'-bi-2-naphthol and hexamethylphosphoramide
PNAS 2004 101: 5417-5420; published online before print March 16 2004, 10.1073/pnas.0307136101 [Abstract] [Full Text] [PDF]  

Brian M. Bocknack, Long-Cheng Wang, and Michael J. Krische
Asymmetric Catalysis Special Feature Part I: Desymmetrization of enone-diones via rhodium-catalyzed diastereo- and enantioselective tandem conjugate addition-aldol cyclization
PNAS 2004 101: 5421-5424; published online before print March 15 2004, 10.1073/pnas.0307120101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Hongmei Li, Celina García, and Patrick J. Walsh
Asymmetric Catalysis Special Feature Part I: Catalytic asymmetric addition of diphenylzinc to cyclic {alpha},{beta}-unsaturated ketones
PNAS 2004 101: 5425-5427; published online before print April 5 2004, 10.1073/pnas.0307119101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Clark R. Landis and Thomas P. Clark
Asymmetric Catalysis Special Feature Part I: Solid-phase synthesis of chiral 3,4-diazaphospholanes and their application to catalytic asymmetric allylic alkylation
PNAS 2004 101: 5428-5432; published online before print February 25 2004, 10.1073/pnas.0307572100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Yuhei Fukuta, Takashi Ohshima, Vijay Gnanadesikan, Tomoyuki Shibuguchi, Tetsuhiro Nemoto, Takaya Kisugi, Tatsufumi Okino, and Masakatsu Shibasaki
Asymmetric Catalysis Special Feature Part I: Enantioselective syntheses and biological studies of aeruginosin 298-A and its analogs: Application of catalytic asymmetric phase-transfer reaction
PNAS 2004 101: 5433-5438; published online before print March 2 2004, 10.1073/pnas.0307154101 [Abstract] [Full Text] [PDF] [Supporting Materials and Methods]  

Scott E. Denmark and Tommy Bui
Asymmetric Catalysis Special Feature Part I: Chiral phosphoramide-catalyzed, enantioselective, directed cross-aldol reactions of aldehydes
PNAS 2004 101: 5439-5444; published online before print April 5 2004, 10.1073/pnas.0307212101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Norihito Tokunaga, Kazuhiro Yoshida, and Tamio Hayashi
Asymmetric Catalysis Special Feature Part I: Mechanistic studies on the catalytic cycle of rhodium-catalyzed asymmetric 1,4-addition of aryltitanate reagents to {alpha},{beta}-unsaturated ketones
PNAS 2004 101: 5445-5449; published online before print February 23 2004, 10.1073/pnas.0307260101 [Abstract] [Full Text] [PDF]  

David M. Hodgson, Tobias Brückl, Rebecca Glen, Agnès H. Labande, Deborah A. Selden, Alexander G. Dossetter, and Alison J. Redgrave
Asymmetric Catalysis Special Feature Part I: Catalytic enantioselective intermolecular cycloadditions of 2-diazo-3,6-diketoester-derived carbonyl ylides with alkene dipolarophiles
PNAS 2004 101: 5450-5454; published online before print March 22 2004, 10.1073/pnas.0307274101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Mark Lautens and Keith Fagnou
Asymmetric Catalysis Special Feature Part I: Rhodium-catalyzed asymmetric ring opening reactions of oxabicyclic alkenes: Catalyst and substrate studies leading to a mechanistic working model
PNAS 2004 101: 5455-5460; published online before print April 5 2004, 10.1073/pnas.0307271101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Michael Reggelin, Sebastian Doerr, Martin Klussmann, Melanie Schultz, and Michael Holbach
Asymmetric Catalysis Special Feature Part I: Helically chiral polymers: A class of ligands for asymmetric catalysis
PNAS 2004 101: 5461-5466; published online before print March 30 2004, 10.1073/pnas.0307443101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Varinder K. Aggarwal, Jonathan Charmant, Leo Dudin, Marina Porcelloni, and Jeffery Richardson
Asymmetric Catalysis Special Feature Part I: Effect of sulfide structure on enantioselectivity in catalytic asymmetric epoxidation of aldehydes: Mechanistic insights and implications
PNAS 2004 101: 5467-5471; published online before print March 19 2004, 10.1073/pnas.0307559101 [Abstract] [Full Text] [PDF] [Supporting Appendix]  

Huw M. L. Davies and Qihui Jin
Asymmetric Catalysis Special Feature Part I: Catalytic asymmetric reactions for organic synthesis: The combined C—H activation/Cope rearrangement
PNAS 2004 101: 5472-5475; published online before print March 15 2004, 10.1073/pnas.0307556101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shu Kobayashi, Masaharu Ueno, Susumu Saito, Yumiko Mizuki, Haruro Ishitani, and Yasuhiro Yamashita
Asymmetric Catalysis Special Feature Part I: Air-stable, storable, and highly efficient chiral zirconium catalysts for enantioselective Mannich-type, aza Diels–Alder, aldol, and hetero Diels–Alder reactions
PNAS 2004 101: 5476-5481; published online before print April 5 2004, 10.1073/pnas.0307870101 [Abstract] [Full Text] [PDF]  

Joel F. Austin, Sung-Gon Kim, Christopher J. Sinz, Wen-Jing Xiao, and David W. C. MacMillan
From the Cover: Asymmetric Catalysis Special Feature Part I: Enantioselective organocatalytic construction of pyrroloindolines by a cascade addition–cyclization strategy: Synthesis of (–)-flustramine B
PNAS 2004 101: 5482-5487; published online before print April 5 2004, 10.1073/pnas.0308177101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tae Seok Seo, Xiaopeng Bai, Hameer Ruparel, Zengmin Li, Nicholas J. Turro, and Jingyue Ju
Photocleavable fluorescent nucleotides for DNA sequencing on a chip constructed by site-specific coupling chemistry
PNAS 2004 101: 5488-5493; published online before print April 2 2004, 10.1073/pnas.0401138101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Steve S. Huang, Ronald L. Koder, Mitchell Lewis, A. Joshua Wand, and P. Leslie Dutton
From the Cover: The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange
PNAS 2004 101: 5536-5541; published online before print March 31 2004, 10.1073/pnas.0306676101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Paul Whitehouse, Timothy Usher, Merritt Ruhlen, and William S.-Y. Wang
Kusunda: An Indo-Pacific language in Nepal
PNAS 2004 101: 5692-5695; published online before print March 31 2004, 10.1073/pnas.0400233101 [Abstract] [Full Text] [PDF] [Supporting Appendix]  

BIOLOGICAL SCIENCES

Biochemistry

Biao Luo, Amanda D. Heard, and Harvey F. Lodish
From the Cover: Small interfering RNA production by enzymatic engineering of DNA (SPEED)
PNAS 2004 101: 5494-5499; published online before print March 15 2004, 10.1073/pnas.0400551101 [Abstract] [Full Text] [PDF] [Supporting Table]  
See Commentary on page 5313

Esti Liani, Allon Eyal, Eyal Avraham, Revital Shemer, Raymonde Szargel, Daniela Berg, Antje Bornemann, Olaf Riess, Christopher A. Ross, Ruth Rott, and Simone Engelender
Ubiquitylation of synphilin-1 and {alpha}-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease
PNAS 2004 101: 5500-5505; published online before print April 2 2004, 10.1073/pnas.0401081101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Thomas J. Lyons, Nancy Y. Villa, Lisa M. Regalla, Brian R. Kupchak, Anna Vagstad, and David J. Eide
Metalloregulation of yeast membrane steroid receptor homologs
PNAS 2004 101: 5506-5511; published online before print April 1 2004, 10.1073/pnas.0306324101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ella H. Sklan, Alexander Lowenthal, Mira Korner, Ya'acov Ritov, Daniel M. Landers, Tuomo Rankinen, Claude Bouchard, Arthur S. Leon, Treva Rice, D. C. Rao, Jack H. Wilmore, James S. Skinner, and Hermona Soreq
Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
PNAS 2004 101: 5512-5517; published online before print April 1 2004, 10.1073/pnas.0307659101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Nina M. Brown, Andrew S. Torres, Peter E. Doan, and Thomas V. O'Halloran
Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase
PNAS 2004 101: 5518-5523; published online before print April 2 2004, 10.1073/pnas.0401175101 [Abstract] [Full Text] [PDF]  

Joseph M. Dhahbi, Hyon-Jeen Kim, Patricia L. Mote, Robert J. Beaver, and Stephen R. Spindler
Temporal linkage between the phenotypic and genomic responses to caloric restriction
PNAS 2004 101: 5524-5529; published online before print March 25 2004, 10.1073/pnas.0305300101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

Christen Brownlee
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Biography of James L. Van Etten
PNAS 2004 101: 5315-5317; published online before print April 5 2004, 10.1073/pnas.0401846101 [Extract] [Full Text] [PDF]  

Ming Kang, Anna Moroni, Sabrina Gazzarrini, Dario DiFrancesco, Gerhard Thiel, Maria Severino, and James L. Van Etten
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Small potassium ion channel proteins encoded by chlorella viruses
PNAS 2004 101: 5318-5324; published online before print February 4 2004, 10.1073/pnas.0307824100 [Abstract] [Full Text] [PDF]  

Tae Seok Seo, Xiaopeng Bai, Hameer Ruparel, Zengmin Li, Nicholas J. Turro, and Jingyue Ju
Photocleavable fluorescent nucleotides for DNA sequencing on a chip constructed by site-specific coupling chemistry
PNAS 2004 101: 5488-5493; published online before print April 2 2004, 10.1073/pnas.0401138101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Thomas J. Avenson, Jeffrey A. Cruz, and David M. Kramer
Modulation of energy-dependent quenching of excitons in antennae of higher plants
PNAS 2004 101: 5530-5535; published online before print April 2 2004, 10.1073/pnas.0401269101 [Abstract] [Full Text] [PDF]  

Steve S. Huang, Ronald L. Koder, Mitchell Lewis, A. Joshua Wand, and P. Leslie Dutton
From the Cover: The HP-1 maquette: From an apoprotein structure to a structured hemoprotein designed to promote redox-coupled proton exchange
PNAS 2004 101: 5536-5541; published online before print March 31 2004, 10.1073/pnas.0306676101 [Abstract] [Full Text] [PDF]  

Cell Biology

Josh E. Baker, Elena B. Krementsova, Guy G. Kennedy, Amy Armstrong, Kathleen M. Trybus, and David M. Warshaw
Myosin V processivity: Multiple kinetic pathways for head-to-head coordination
PNAS 2004 101: 5542-5546; published online before print March 31 2004, 10.1073/pnas.0307247101 [Abstract] [Full Text] [PDF]  

Chung-Hyun Cho, Richard A. Kammerer, Hyuek Jong Lee, Michel O. Steinmetz, Young Shin Ryu, Sung Ho Lee, Kunio Yasunaga, Kyung-Tae Kim, Injune Kim, Han-Ho Choi, Won Kim, Sung Hyun Kim, Sung Kwang Park, Gyun Min Lee, and Gou Young Koh
COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity
PNAS 2004 101: 5547-5552; published online before print April 1 2004, 10.1073/pnas.0307574101 [Abstract] [Full Text] [PDF]  

Chung-Hyun Cho, Richard A. Kammerer, Hyuek Jong Lee, Kunio Yasunaga, Kyung-Tae Kim, Han-Ho Choi, Won Kim, Sung Hyun Kim, Sung Kwang Park, Gyun Min Lee, and Gou Young Koh
Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis
PNAS 2004 101: 5553-5558; published online before print April 1 2004, 10.1073/pnas.0307575101 [Abstract] [Full Text] [PDF]  

Yan Hu, Ting Wang, Gary D. Stormo, and Jeffrey I. Gordon
RNA interference of achaete–scute homolog 1 in mouse prostate neuroendocrine cells reveals its gene targets and DNA binding sites
PNAS 2004 101: 5559-5564; published online before print April 1 2004, 10.1073/pnas.0306988101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Brad J. Marsh, Niels Volkmann, J. Richard McIntosh, and Kathryn E. Howell
Direct continuities between cisternae at different levels of the Golgi complex in glucose-stimulated mouse islet beta cells
PNAS 2004 101: 5565-5570; published online before print April 2 2004, 10.1073/pnas.0401242101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cunxi Li, Jeffrey L. Franklin, Ramona Graves-Deal, W. Gray Jerome, Zheng Cao, and Robert J. Coffey
Myristoylated Naked2 escorts transforming growth factor {alpha} to the basolateral plasma membrane of polarized epithelial cells
PNAS 2004 101: 5571-5576; published online before print April 2 2004, 10.1073/pnas.0401294101 [Abstract] [Full Text] [PDF]  

A. C. Badin-Larçon, C. Boscheron, J. M. Soleilhac, M. Piel, C. Mann, E. Denarier, A. Fourest-Lieuvin, L. Lafanechère, M. Bornens, and D. Job
From the Cover: Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin
PNAS 2004 101: 5577-5582; published online before print March 18 2004, 10.1073/pnas.0307917101 [Abstract] [Full Text] [PDF]  

Nicole K. Noren, Mark Lu, Andrew L. Freeman, Mitchell Koolpe, and Elena B. Pasquale
Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth
PNAS 2004 101: 5583-5588; published online before print April 5 2004, 10.1073/pnas.0401381101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Evolution

Xiaoyu Zhang and Susan R. Wessler
Genome-wide comparative analysis of the transposable elements in the related species Arabidopsis thaliana and Brassica oleracea
PNAS 2004 101: 5589-5594; published online before print April 2 2004, 10.1073/pnas.0401243101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Glenn L. Holbrook and Coby Schal
Maternal investment affects offspring phenotypic plasticity in a viviparous cockroach
PNAS 2004 101: 5595-5597; published online before print April 2 2004, 10.1073/pnas.0400209101 [Abstract] [Full Text] [PDF]  

Immunology

Jennifer M. Lund, Lena Alexopoulou, Ayuko Sato, Margaret Karow, Niels C. Adams, Nicholas W. Gale, Akiko Iwasaki, and Richard A. Flavell
Recognition of single-stranded RNA viruses by Toll-like receptor 7
PNAS 2004 101: 5598-5603; published online before print March 19 2004, 10.1073/pnas.0400937101 [Abstract] [Full Text] [PDF]  

Ben G. Wen, Mathew T. Pletcher, Masaki Warashina, Sun Hui Choe, Niusha Ziaee, Tim Wiltshire, Karsten Sauer, and Michael P. Cooke
Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity
PNAS 2004 101: 5604-5609; published online before print April 2 2004, 10.1073/pnas.0306907101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Katharina M. Huster, Verena Busch, Matthias Schiemann, Kathrin Linkemann, Kristen M. Kerksiek, Hermann Wagner, and Dirk H. Busch
Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets
PNAS 2004 101: 5610-5615; published online before print March 25 2004, 10.1073/pnas.0308054101 [Abstract] [Full Text] [PDF]  

Kimberly S. Schluns, Elizabeth C. Nowak, Arturo Cabrera-Hernandez, Lynn Puddington, Leo Lefrançois, and Hector L. Aguila
Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor {alpha} expression
PNAS 2004 101: 5616-5621; published online before print April 1 2004, 10.1073/pnas.0307442101 [Abstract] [Full Text] [PDF]  

Medical Sciences

David Bradley
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Biography of Zhu Chen
PNAS 2004 101: 5325-5327; published online before print April 5 2004, 10.1073/pnas.0401849101 [Extract] [Full Text] [PDF]  

Zhi-Xiang Shen, Zhan-Zhong Shi, Jing Fang, Bai-Wei Gu, Jun-Min Li, Yong-Mei Zhu, Jing-Yi Shi, Pei-Zheng Zheng, Hua Yan, Yuan-Fang Liu, Yu Chen, Yang Shen, Wen Wu, Wei Tang, Samuel Waxman, Hugues de Thé, Zhen-Yi Wang, Sai-Juan Chen, and Zhu Chen
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia
PNAS 2004 101: 5328-5335; published online before print March 24 2004, 10.1073/pnas.0400053101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Federica del Monte, Djamel Lebeche, J. Luis Guerrero, Tsuyoshi Tsuji, Angelia A. Doye, Judith K. Gwathmey, and Roger J. Hajjar
From the Cover: Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling
PNAS 2004 101: 5622-5627; published online before print March 25 2004, 10.1073/pnas.0305778101 [Abstract] [Full Text] [PDF]  

Richard K. Plemper, Karl J. Erlandson, Ami S. Lakdawala, Aiming Sun, Andrew Prussia, Jutatip Boonsombat, Esin Aki-Sener, Ismail Yalcin, Ilkay Yildiz, Ozlem Temiz-Arpaci, Betul Tekiner, Dennis C. Liotta, James P. Snyder, and Richard W. Compans
A target site for template-based design of measles virus entry inhibitors
PNAS 2004 101: 5628-5633; published online before print March 31 2004, 10.1073/pnas.0308520101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Claudia Monaco, Evangelos Andreakos, Serafim Kiriakidis, Claudia Mauri, Colin Bicknell, Brian Foxwell, Nicholas Cheshire, Ewa Paleolog, and Marc Feldmann
Canonical pathway of nuclear factor {kappa}B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis
PNAS 2004 101: 5634-5639; published online before print April 2 2004, 10.1073/pnas.0401060101 [Abstract] [Full Text] [PDF]  

Microbiology

Zhi-Qiang Zhang, Stephen W. Wietgrefe, Qingsheng Li, Marta Dykhuizen Shore, Lijie Duan, Cavan Reilly, Jeffrey D. Lifson, and Ashley T. Haase
Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection
PNAS 2004 101: 5640-5645; published online before print April 2 2004, 10.1073/pnas.0308425101 [Abstract] [Full Text] [PDF] [Supporting Methods]  

Rekha Seshadri, Garry S. A. Myers, Hervé Tettelin, Jonathan A. Eisen, John F. Heidelberg, Robert J. Dodson, Tanja M. Davidsen, Robert T. DeBoy, Derrick E. Fouts, Dan H. Haft, Jeremy Selengut, Qinghu Ren, Lauren M. Brinkac, Ramana Madupu, Jamie Kolonay, Scott A. Durkin, Sean C. Daugherty, Jyoti Shetty, Alla Shvartsbeyn, Elizabeth Gebregeorgis, Keita Geer, Getahun Tsegaye, Joel Malek, Bola Ayodeji, Sofiya Shatsman, Michael P. McLeod, David Smajs, Jerrilyn K. Howell, Sangita Pal, Anita Amin, Pankaj Vashisth, Thomas Z. McNeill, Qin Xiang, Erica Sodergren, Ernesto Baca, George M. Weinstock, Steven J. Norris, Claire M. Fraser, and Ian T. Paulsen
Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
PNAS 2004 101: 5646-5651; published online before print April 2 2004, 10.1073/pnas.0307639101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hongzhan Xu, Evguenia S. Svarovskaia, Rebekah Barr, Yijun Zhang, Mohammad A. Khan, Klaus Strebel, and Vinay K. Pathak
A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion
PNAS 2004 101: 5652-5657; published online before print March 30 2004, 10.1073/pnas.0400830101 [Abstract] [Full Text] [PDF]  

Neuroscience

Melissa Marino
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Biography of Joseph S. Takahashi
PNAS 2004 101: 5336-5338; published online before print April 5 2004, 10.1073/pnas.0401895101 [Extract] [Full Text] [PDF]  

Seung-Hee Yoo, Shin Yamazaki, Phillip L. Lowrey, Kazuhiro Shimomura, Caroline H. Ko, Ethan D. Buhr, Sandra M. Siepka, Hee-Kyung Hong, Won Jun Oh, Ook Joon Yoo, Michael Menaker, and Joseph S. Takahashi
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
PNAS 2004 101: 5339-5346; published online before print February 12 2004, 10.1073/pnas.0308709101 [Abstract] [Full Text] [PDF]  

Pietro Pietrini, Maura L. Furey, Emiliano Ricciardi, M. Ida Gobbini, W.-H. Carolyn Wu, Leonardo Cohen, Mario Guazzelli, and James V. Haxby
Beyond sensory images: Object-based representation in the human ventral pathway
PNAS 2004 101: 5658-5663; published online before print April 2 2004, 10.1073/pnas.0400707101 [Abstract] [Full Text] [PDF]  

Joseph A. Kim, Kelly A. Pollak, Gregory O. Hjelmstad, and Howard L. Fields
A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism
PNAS 2004 101: 5664-5669; published online before print April 2 2004, 10.1073/pnas.0401373101 [Abstract] [Full Text] [PDF]  

Jan-Eric Grunwald, Sven Schörnich, and Lutz Wiegrebe
Classification of natural textures in echolocation
PNAS 2004 101: 5670-5674; published online before print April 1 2004, 10.1073/pnas.0308029101 [Abstract] [Full Text] [PDF]  

Physiology

Christopher Thaler, Annette C. Gray, and Diane Lipscombe
Cumulative inactivation of N-type CaV2.2 calcium channels modified by alternative splicing
PNAS 2004 101: 5675-5679; published online before print April 1 2004, 10.1073/pnas.0303402101 [Abstract] [Full Text] [PDF]  

Plant Biology

Shengwu Ma, Yan Huang, ZiQin Yin, Rima Menassa, James E. Brandle, and Anthony M. Jevnikar
Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4
PNAS 2004 101: 5680-5685; published online before print March 31 2004, 10.1073/pnas.0307420101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Psychology

Yulin Qin, Cameron S. Carter, Eli M. Silk, V. Andrew Stenger, Kate Fissell, Adam Goode, and John R. Anderson
The change of the brain activation patterns as children learn algebra equation solving
PNAS 2004 101: 5686-5691; published online before print April 2 2004, 10.1073/pnas.0401227101 [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for Cotton, Avian migration phenology and global climate change, PNAS 2003 100:12219-12222 [Extract] [Full Text] [PDF]  

Correction for Smith et al., Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problem, PNAS 2004 101:3709-3714 [Extract] [Full Text] [PDF]  

Correction for Ohgishi et al., Functional analysis of each blue light receptor, cry1, cry2, phot1, and phot2, by using combinatorial multiple mutants in Arabidopsis, PNAS 2004 101:2223-2228 [Extract] [Full Text] [PDF]  

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