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COMMENTARIES

Yibin Wang and Joshua I. Goldhaber

Return of calcium: Manipulating intracellular calcium to prevent cardiac pathologies
PNAS 2004 101: 5697-5698; published online before print April 12 2004, 10.1073/pnas.0401518101 [Extract] [Full Text] [PDF]  

Roland Brandstaetter

Circadian lessons from peripheral clocks: Is the time of the mammalian pacemaker up?
PNAS 2004 101: 5699-5700; published online before print April 12 2004, 10.1073/pnas.0401378101 [Extract] [Full Text] [PDF]  

Soumya S. Ray and Peter T. Lansbury, Jr.

A possible therapeutic target for Lou Gehrig's disease
PNAS 2004 101: 5701-5702; published online before print April 12 2004, 10.1073/pnas.0401934101 [Extract] [Full Text] [PDF]  
See companion article on page 5976

Y.-A. Barde

Death of injured neurons caused by the precursor of nerve growth factor
PNAS 2004 101: 5703-5704; published online before print April 12 2004, 10.1073/pnas.0401374101 [Extract] [Full Text] [PDF]  
See companion article on page 6226

PERSPECTIVES

Manfred T. Reetz

Asymmetric Catalysis Special Feature Part II: Controlling the enantioselectivity of enzymes by directed evolution: Practical and theoretical ramifications
PNAS 2004 101: 5716-5722; published online before print April 12 2004, 10.1073/pnas.0306866101 [Abstract] [Full Text] [PDF]  

Andreas Pfaltz and William J. Drury, III

Asymmetric Catalysis Special Feature Part II: Design of chiral ligands for asymmetric catalysis: From C₂-symmetric P,P- and N,N-ligands to sterically and electronically nonsymmetrical P,N-ligands
PNAS 2004 101: 5723-5726; published online before print April 6 2004, 10.1073/pnas.0307152101 [Abstract] [Full Text] [PDF]  

Ilya D. Gridnev and John M. Brown

Asymmetric Catalysis Special Feature Part II: Asymmetric autocatalysis: Novel structures, novel mechanism?
PNAS 2004 101: 5727-5731; published online before print April 1 2004, 10.1073/pnas.0308178101 [Abstract] [Full Text] [PDF]  

Donna G. Blackmond

Asymmetric Catalysis Special Feature Part II: Asymmetric autocatalysis and its implications for the origin of homochirality
PNAS 2004 101: 5732-5736; published online before print April 5 2004, 10.1073/pnas.0308363101 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

Kai Kadau, Timothy C. Germann, Nicolas G. Hadjiconstantinou, Peter S. Lomdahl, Guy Dimonte, Brad Lee Holian, and Berni J. Alder

Nanohydrodynamics simulations: An atomistic view of the Rayleigh–Taylor instability
PNAS 2004 101: 5851-5855; published online before print April 5 2004, 10.1073/pnas.0401228101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ajit P. Joglekar, Hsiao-hua Liu, Edgar Meyhöfer, Gerard Mourou, and Alan J. Hunt

Optics at critical intensity: Applications to nanomorphing
PNAS 2004 101: 5856-5861; published online before print April 7 2004, 10.1073/pnas.0307470101 [Abstract] [Full Text] [PDF]  

Chemistry

Akira Watanabe, Tatsuya Uchida, Ryo Irie, and Tsutomu Katsuki

Asymmetric Catalysis Special Feature Part II: Zr[bis(salicylidene)ethylenediaminato]-mediated Baeyer–Villiger oxidation: Stereospecific synthesis of abnormal and normal lactones
PNAS 2004 101: 5737-5742; published online before print April 8 2004, 10.1073/pnas.0306992101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Ilja V. Khavrutskii, Djamaladdin G. Musaev, and Keiji Morokuma

Asymmetric Catalysis Special Feature Part II: Epoxidation of unfunctionalized olefins by Mn(salen) catalyst using organic peracids as oxygen source: A theoretical study
PNAS 2004 101: 5743-5748; published online before print April 6 2004, 10.1073/pnas.0307082101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chunmei Wei, Joel T. Mague, and Chao-Jun Li

Asymmetric Catalysis Special Feature Part II: Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines
PNAS 2004 101: 5749-5754; published online before print April 5 2004, 10.1073/pnas.0307150101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Zhuo Tang, Fan Jiang, Xin Cui, Liu-Zhu Gong, Ai-Qiao Mi, Yao-Zhong Jiang, and Yun-Dong Wu

Asymmetric Catalysis Special Feature Part II: Enantioselective direct aldol reactions catalyzed by L-prolinamide derivatives
PNAS 2004 101: 5755-5760; published online before print April 12 2004, 10.1073/pnas.0307176101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Michaela Edin, Johannes Steinreiber, and Jan-E. Bäckvall

Asymmetric Catalysis Special Feature Part II: One-pot synthesis of enantiopure syn-1,3-diacetates from racemic syn/anti mixtures of 1,3-diols by dynamic kinetic asymmetric transformation
PNAS 2004 101: 5761-5766; published online before print April 6 2004, 10.1073/pnas.0307146101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Koichi Mikami and Manabu Hatano

Asymmetric Catalysis Special Feature Part II: Palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings or oxidized five-membered trifluoroacetates
PNAS 2004 101: 5767-5769; published online before print April 12 2004, 10.1073/pnas.0307217101 [Abstract] [Full Text] [PDF]  

Travis Dudding and Kendall N. Houk

Asymmetric Catalysis Special Feature Part II: Computational predictions of stereochemistry in asymmetric thiazolium- and triazolium-catalyzed benzoin condensations
PNAS 2004 101: 5770-5775; published online before print April 12 2004, 10.1073/pnas.0307256101 [Abstract] [Full Text] [PDF] [Supporting Data Set]  

Zhiguo J. Song, Anthony O. King, Marjorie S. Waters, Fengrui Lang, Daniel Zewge, Matthew Bio, Johnnie L. Leazer, Jr., Gary Javadi, Amude Kassim, David M. Tschaen, Robert A. Reamer, Thorsten Rosner, Jennifer R. Chilenski, David J. Mathre, R. P. Volante, and Richard Tillyer

Asymmetric Catalysis Special Feature Part II: An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction
PNAS 2004 101: 5776-5781; published online before print April 12 2004, 10.1073/pnas.0307415101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ei-ichi Negishi, Ze Tan, Bo Liang, and Tibor Novak

Asymmetric Catalysis Special Feature Part II: An efficient and general route to reduced polypropionates via Zr-catalyzed asymmetric CC bond formation
PNAS 2004 101: 5782-5787; published online before print April 8 2004, 10.1073/pnas.0307514101 [Abstract] [Full Text] [PDF] [Supporting Text]  

William A. Greenberg, Alexander Varvak, Sarah R. Hanson, Kelvin Wong, Hongjun Huang, Pei Chen, and Mark J. Burk

Asymmetric Catalysis Special Feature Part II: Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
PNAS 2004 101: 5788-5793; published online before print April 6 2004, 10.1073/pnas.0307563101 [Abstract] [Full Text] [PDF]  

Matthew Hickey, David Goeddel, Zackary Crane, and Yian Shi

Asymmetric Catalysis Special Feature Part II: Highly enantioselective epoxidation of styrenes: Implication of an electronic effect on the competition between spiro and planar transition states
PNAS 2004 101: 5794-5798; published online before print April 6 2004, 10.1073/pnas.0307548101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Séverine Jeulin, Sébastien Duprat de Paule, Virginie Ratovelomanana-Vidal, Jean-Pierre Genêt, Nicolas Champion, and Philippe Dellis

Asymmetric Catalysis Special Feature Part II: Chiral biphenyl diphosphines for asymmetric catalysis: Stereoelectronic design and industrial perspectives
PNAS 2004 101: 5799-5804; published online before print March 18 2004, 10.1073/pnas.0307620101 [Abstract] [Full Text] [PDF]  

Gabriel S. Weatherhead, G. A. Cortez, Richard R. Schrock, and Amir H. Hoveyda

Asymmetric Catalysis Special Feature Part II: Mo-catalyzed asymmetric olefin metathesis in target-oriented synthesis: Enantioselective synthesis of (+)-africanol
PNAS 2004 101: 5805-5809; published online before print March 31 2004, 10.1073/pnas.0307589101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Patrick Y. Toullec, Cristina Bonaccorsi, Antonio Mezzetti, and Antonio Togni

Asymmetric Catalysis Special Feature Part II: Expanding the scope of asymmetric electrophilic atom-transfer reactions: Titanium- and ruthenium-catalyzed hydroxylation of -ketoesters
PNAS 2004 101: 5810-5814; published online before print April 7 2004, 10.1073/pnas.0307716101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Liqin Qiu, Jing Wu, Shusun Chan, Terry T.-L. Au-Yeung, Jian-Xin Ji, Rongwei Guo, Cheng-Chao Pai, Zhongyuan Zhou, Xingshu Li, Qing-Hua Fan, and Albert S. C. Chan

Asymmetric Catalysis Special Feature Part II: Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation
PNAS 2004 101: 5815-5820; published online before print April 5 2004, 10.1073/pnas.0307774101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Matthew P. Rainka, Yimon Aye, and Stephen L. Buchwald

Asymmetric Catalysis Special Feature Part II: Copper-catalyzed asymmetric conjugate reduction as a route to novel -azaheterocyclic acid derivatives
PNAS 2004 101: 5821-5823; published online before print April 5 2004, 10.1073/pnas.0307764101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Keiji Maruoka, Eiji Tayama, and Takashi Ooi

Asymmetric Catalysis Special Feature Part II: Stereoselective terminal functionalization of small peptides for catalytic asymmetric synthesis of unnatural peptides
PNAS 2004 101: 5824-5829; published online before print April 12 2004, 10.1073/pnas.0307725101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Andreas Leitner, Chutian Shu, and John F. Hartwig

Asymmetric Catalysis Special Feature Part II: Editing the stereochemical elements in an iridium catalyst for enantioselective allylic amination
PNAS 2004 101: 5830-5833; published online before print April 5 2004, 10.1073/pnas.0307967101 [Abstract] [Full Text] [PDF]  

Ben L. Feringa, Ramón Badorrey, Diego Peña, Syuzanna R. Harutyunyan, and Adriaan J. Minnaard

Asymmetric Catalysis Special Feature Part II: Copper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic enones
PNAS 2004 101: 5834-5838; published online before print April 9 2004, 10.1073/pnas.0308008101 [Abstract] [Full Text] [PDF]  

Benjamin List, Linh Hoang, and Harry J. Martin

Asymmetric Catalysis Special Feature Part II: New mechanistic studies on the proline-catalyzed aldol reaction
PNAS 2004 101: 5839-5842; published online before print April 8 2004, 10.1073/pnas.0307979101 [Abstract] [Full Text] [PDF]  

Roger Fässler, Craig S. Tomooka, Doug E. Frantz, and Erick M. Carreira

Asymmetric Catalysis Special Feature Part II: Infrared spectroscopic investigations on the metallation of terminal alkynes by Zn(OTf)₂
PNAS 2004 101: 5843-5845; published online before print April 5 2004, 10.1073/pnas.0308326101 [Abstract] [Full Text] [PDF]  

Avinash N. Thadani, Ana R. Stankovic, and Viresh H. Rawal

Asymmetric Catalysis Special Feature Part II: Enantioselective Diels–Alder reactions catalyzed by hydrogen bonding
PNAS 2004 101: 5846-5850; published online before print April 6 2004, 10.1073/pnas.0308545101 [Abstract] [Full Text] [PDF]  

Chengguo Xing, Jacob R. LaPorte, Joseph K. Barbay, and Andrew G. Myers

Identification of GAPDH as a protein target of the saframycin antiproliferative agents
PNAS 2004 101: 5862-5866; published online before print April 12 2004, 10.1073/pnas.0307476101 [Abstract] [Full Text] [PDF]  

Geophysics

Steven D. Jacobsen, Hartmut Spetzler, Hans J. Reichmann, and Joseph R. Smyth

Shear waves in the diamond-anvil cell reveal pressure-induced instability in (Mg,Fe)O
PNAS 2004 101: 5867-5871; published online before print April 12 2004, 10.1073/pnas.0401564101 [Abstract] [Full Text] [PDF]  

Mathematics

SOCIAL SCIENCES

Anthropology

Richard G. Klein, Graham Avery, Kathryn Cruz-Uribe, David Halkett, John E. Parkington, Teresa Steele, Thomas P. Volman, and Royden Yates Inaugural Article by a Recently Elected Academy Member: Inaugural Article: The Ysterfontein 1 Middle Stone Age site, South Africa, and early human exploitation of coastal resources PNAS 2004 101: 5708-5715; published online before print March 8 2004, 10.1073/pnas.0400528101 [Abstract] [Full Text] [PDF]

BIOLOGICAL SCIENCES

Agricultural Sciences

Brian L. Weiss and W. Reuben Kaufman

Two feeding-induced proteins from the male gonad trigger engorgement of the female tick Amblyomma hebraeum
PNAS 2004 101: 5874-5879; published online before print April 6 2004, 10.1073/pnas.0307529101 [Abstract] [Full Text] [PDF]  

Raúl Fernández-Gonzalez, Pedro Moreira, Ainhoa Bilbao, Adela Jiménez, Miriam Pérez-Crespo, Miguel Angel Ramírez, Fernando Rodríguez De Fonseca, Belén Pintado, and Alfonso Gutiérrez-Adán

Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior
PNAS 2004 101: 5880-5885; published online before print April 12 2004, 10.1073/pnas.0308560101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biochemistry

David E. Sleat, Jennifer A. Wiseman, Mukarram El-Banna, Sandy M. Price, Lucie Verot, Michael M. Shen, G. Stephen Tint, Marie T. Vanier, Steven U. Walkley, and Peter Lobel

Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport
PNAS 2004 101: 5886-5891; published online before print April 7 2004, 10.1073/pnas.0308456101 [Abstract] [Full Text] [PDF]  

Roman Fedorov, Ryan Vasan, Dipak K. Ghosh, and Ilme Schlichting

Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design
PNAS 2004 101: 5892-5897; published online before print April 7 2004, 10.1073/pnas.0306588101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yuling Shi, Sujatha L. Venkataraman, Gerald E. Dodson, Angela M. Mabb, Scott LeBlanc, and Randal S. Tibbetts

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress
PNAS 2004 101: 5898-5903; published online before print April 8 2004, 10.1073/pnas.0307718101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Thomas G. Gillette, Fernando Gonzalez, Agnes Delahodde, Stephen Albert Johnston, and Thomas Kodadek

Physical and functional association of RNA polymerase II and the proteasome
PNAS 2004 101: 5904-5909; published online before print April 6 2004, 10.1073/pnas.0305411101 [Abstract] [Full Text] [PDF]  

Hailong Zhang, Benjamin Tweel, and Liang Tong

Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop
PNAS 2004 101: 5910-5915; published online before print April 12 2004, 10.1073/pnas.0400891101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Yael Eisenberg-Domovich, Yael Pazy, Orit Nir, Bilha Raboy, Edward A. Bayer, Meir Wilchek, and Oded Livnah

Structural elements responsible for conversion of streptavidin to a pseudoenzyme
PNAS 2004 101: 5916-5921; published online before print April 12 2004, 10.1073/pnas.0308541101 [Abstract] [Full Text] [PDF]  

Luca Jovine, Huayu Qi, Zev Williams, Eveline S. Litscher, and Paul M. Wassarman

A duplicated motif controls assembly of zona pellucida domain proteins
PNAS 2004 101: 5922-5927; published online before print April 12 2004, 10.1073/pnas.0401600101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Roxana A. Radu, Nathan L. Mata, Aarti Bagla, and Gabriel H. Travis

Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration
PNAS 2004 101: 5928-5933; published online before print April 5 2004, 10.1073/pnas.0308302101 [Abstract] [Full Text] [PDF]  

Esti Yeger-Lotem, Shmuel Sattath, Nadav Kashtan, Shalev Itzkovitz, Ron Milo, Ron Y. Pinter, Uri Alon, and Hanah Margalit

Network motifs in integrated cellular networks of transcription–regulation and protein–protein interaction
PNAS 2004 101: 5934-5939; published online before print April 12 2004, 10.1073/pnas.0306752101 [Abstract] [Full Text] [PDF]  

Maolin Guo, B. Bhaskar, Huiying Li, Tiffany P. Barrows, and Thomas L. Poulos

Crystal structure and characterization of a cytochrome c peroxidase–cytochrome c site-specific cross-link
PNAS 2004 101: 5940-5945; published online before print April 7 2004, 10.1073/pnas.0306708101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Andreas Matthies, K. V. Rajagopalan, Ralf R. Mendel, and Silke Leimkühler

Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans
PNAS 2004 101: 5946-5951; published online before print April 8 2004, 10.1073/pnas.0308191101 [Abstract] [Full Text] [PDF]  

Kaustubha R. Qanungo, Daniel Shaji, Manjula Mathur, and Amiya K. Banerjee

Two RNA polymerase complexes from vesicular stomatitis virus-infected cells that carry out transcription and replication of genome RNA
PNAS 2004 101: 5952-5957; published online before print April 6 2004, 10.1073/pnas.0401449101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Kirk Beebe, Eve Merriman, Lluis Ribas de Pouplana, and Paul Schimmel

A domain for editing by an archaebacterial tRNA synthetase
PNAS 2004 101: 5958-5963; published online before print April 12 2004, 10.1073/pnas.0401530101 [Abstract] [Full Text] [PDF]  

Mark C. Carroll, Jody B. Girouard, Janella L. Ulloa, Jamuna R. Subramaniam, Phillip C. Wong, Joan Selverstone Valentine, and Valeria Cizewski Culotta

Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone
PNAS 2004 101: 5964-5969; published online before print April 6 2004, 10.1073/pnas.0308298101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

Ravi Radhakrishnan and Tamar Schlick

Orchestration of cooperative events in DNA synthesis and repair mechanism unraveled by transition path sampling of DNA polymerase 's closing
PNAS 2004 101: 5970-5975; published online before print April 6 2004, 10.1073/pnas.0308585101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Michael A. Hough, J. Günter Grossmann, Svetlana V. Antonyuk, Richard W. Strange, Peter A. Doucette, Jorge A. Rodriguez, Lisa J. Whitson, P. John Hart, Lawrence J. Hayward, Joan Selverstone Valentine, and S. Samar Hasnain From the Cover: Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants PNAS 2004 101: 5976-5981; published online before print March 31 2004, 10.1073/pnas.0305143101 [Abstract] [Full Text] [PDF] [Supporting Figures]   See Commentary on page 5701

Richard H. G. Baxter, Nina Ponomarenko, Vukica Srajer, Reinhard Pahl, Keith Moffat, and James R. Norris

Time-resolved crystallographic studies of light-induced structural changes in the photosynthetic reaction center
PNAS 2004 101: 5982-5987; published online before print April 8 2004, 10.1073/pnas.0306840101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Sanguk Kim, Aaron K. Chamberlain, and James U. Bowie

Membrane channel structure of Helicobacter pylori vacuolating toxin: Role of multiple GXXXG motifs in cylindrical channels
PNAS 2004 101: 5988-5991; published online before print April 5 2004, 10.1073/pnas.0308694101 [Abstract] [Full Text] [PDF]  

Yann Marcy, Jacques Prost, Marie-France Carlier, and Cécile Sykes

Forces generated during actin-based propulsion: A direct measurement by micromanipulation
PNAS 2004 101: 5992-5997; published online before print April 12 2004, 10.1073/pnas.0307704101 [Abstract] [Full Text] [PDF] [Supporting Information]  

David R. Nutt and Markus Meuwly

CO migration in native and mutant myoglobin: Atomistic simulations for the understanding of protein function
PNAS 2004 101: 5998-6002; published online before print April 5 2004, 10.1073/pnas.0306712101 [Abstract] [Full Text] [PDF]  

Andrei Fokine, Paul R. Chipman, Petr G. Leiman, Vadim V. Mesyanzhinov, Venigalla B. Rao, and Michael G. Rossmann

Molecular architecture of the prolate head of bacteriophage T4
PNAS 2004 101: 6003-6008; published online before print April 7 2004, 10.1073/pnas.0400444101 [Abstract] [Full Text] [PDF]  

Cell Biology

Ryuichi Takezawa, Carsten Schmitz, Philippe Demeuse, Andrew M. Scharenberg, Reinhold Penner, and Andrea Fleig

Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain
PNAS 2004 101: 6009-6014; published online before print April 6 2004, 10.1073/pnas.0307565101 [Abstract] [Full Text] [PDF]  

Developmental Biology

Yuki Kimura, Nina Jones, Michael Klüppel, Masanori Hirashima, Kazunobu Tachibana, Jason B. Cohn, Jeffrey L. Wrana, Tony Pawson, and Alan Bernstein

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages
PNAS 2004 101: 6015-6020; published online before print April 5 2004, 10.1073/pnas.0305363101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rosa Barrio and Jose F. de Celis

Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway
PNAS 2004 101: 6021-6026; published online before print April 12 2004, 10.1073/pnas.0401590101 [Abstract] [Full Text] [PDF]  

Xiaoxia Qi, Teng-Guo Li, Jing Hao, Jie Hu, Jing Wang, Holly Simmons, Shigeto Miura, Yuji Mishina, and Guang-Quan Zhao

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways
PNAS 2004 101: 6027-6032; published online before print April 9 2004, 10.1073/pnas.0401367101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sandra Luikenhuis, Emanuela Giacometti, Caroline F. Beard, and Rudolf Jaenisch

Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
PNAS 2004 101: 6033-6038; published online before print April 6 2004, 10.1073/pnas.0401626101 [Abstract] [Full Text] [PDF]  

Ecology

Kerry A. Brown and Jessica Gurevitch

Long-term impacts of logging on forest diversity in Madagascar
PNAS 2004 101: 6045-6049; published online before print April 5 2004, 10.1073/pnas.0401456101 [Abstract] [Full Text] [PDF]  

Evolution

William A. Cresko, Angel Amores, Catherine Wilson, Joy Murphy, Mark Currey, Patrick Phillips, Michael A. Bell, Charles B. Kimmel, and John H. Postlethwait

Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations
PNAS 2004 101: 6050-6055; published online before print April 6 2004, 10.1073/pnas.0308479101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Nils C. Stenseth, Dorothee Ehrich, Eli Knispel Rueness, Ole C. Lingjærde, Kung-Sik Chan, Stan Boutin, Mark O'Donoghue, David A. Robinson, Hildegunn Viljugrein, and Kjetill S. Jakobsen From The Cover: The effect of climatic forcing on population synchrony and genetic structuring of the Canadian lynx PNAS 2004 101: 6056-6061; published online before print April 5 2004, 10.1073/pnas.0307123101 [Abstract] [Full Text] [PDF] [Supporting Information]

Genetics

Andrew I. Su, Tim Wiltshire, Serge Batalov, Hilmar Lapp, Keith A. Ching, David Block, Jie Zhang, Richard Soden, Mimi Hayakawa, Gabriel Kreiman, Michael P. Cooke, John R. Walker, and John B. Hogenesch

A gene atlas of the mouse and human protein-encoding transcriptomes
PNAS 2004 101: 6062-6067; published online before print April 9 2004, 10.1073/pnas.0400782101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Elizabeth M. Prescott, Yvonne N. Osheim, Hannah S. Jones, Claudia M. Alen, Judith G. Roan, Ronald H. Reeder, Ann L. Beyer, and Nick J. Proudfoot

Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p
PNAS 2004 101: 6068-6073; published online before print April 8 2004, 10.1073/pnas.0401393101 [Abstract] [Full Text] [PDF]  

Tieming Lang, Mausumi Maitra, Daniela Starcevic, Shu-Xia Li, and Joann B. Sweasy

A DNA polymerase mutant from colon cancer cells induces mutations
PNAS 2004 101: 6074-6079; published online before print April 9 2004, 10.1073/pnas.0308571101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Natalie Erdmann, Yie Liu, and Lea Harrington

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice
PNAS 2004 101: 6080-6085; published online before print April 12 2004, 10.1073/pnas.0401580101 [Abstract] [Full Text] [PDF]  

Masaki Mizunuma, Kazunori Miyamura, Dai Hirata, Hiroshi Yokoyama, and Tokichi Miyakawa

Involvement of S-adenosylmethionine in G₁ cell-cycle regulation in Saccharomyces cerevisiae
PNAS 2004 101: 6086-6091; published online before print April 8 2004, 10.1073/pnas.0308314101 [Abstract] [Full Text] [PDF]  

Immunology

Concepción Marañón, Jean-François Desoutter, Guillaume Hoeffel, William Cohen, Daniel Hanau, and Anne Hosmalin

Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4⁺ T lymphocytes
PNAS 2004 101: 6092-6097; published online before print April 12 2004, 10.1073/pnas.0304860101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Barbara Marinari, Antonio Costanzo, Valeria Marzano, Enza Piccolella, and Loretta Tuosto

CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-B subunits on IL-8 and Bcl-xL gene promoters
PNAS 2004 101: 6098-6103; published online before print April 12 2004, 10.1073/pnas.0308688101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Brian E. Collins, Ola Blixt, Alexis R. DeSieno, Nicolai Bovin, Jamey D. Marth, and James C. Paulson

Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact
PNAS 2004 101: 6104-6109; published online before print April 12 2004, 10.1073/pnas.0400851101 [Abstract] [Full Text] [PDF]  

Myoung Ho Jang, Mi-Na Kweon, Koichi Iwatani, Masafumi Yamamoto, Kazutaka Terahara, Chihiro Sasakawa, Toshihiko Suzuki, Tomonori Nochi, Yoshifumi Yokota, Paul D. Rennert, Takachika Hiroi, Hiroshi Tamagawa, Hideki Iijima, Jun Kunisawa, Yoshikazu Yuki, and Hiroshi Kiyono

Intestinal villous M cells: An antigen entry site in the mucosal epithelium
PNAS 2004 101: 6110-6115; published online before print April 7 2004, 10.1073/pnas.0400969101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Benjamin J. Marsland, Nicola L. Harris, Mali Camberis, Manfred Kopf, Sarah M. Hook, and Graham Le Gros

Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells
PNAS 2004 101: 6116-6121; published online before print April 12 2004, 10.1073/pnas.0401582101 [Abstract] [Full Text] [PDF]  

Patrick W. B. Derksen, Esther Tjin, Helen P. Meijer, Melanie D. Klok, Harold D. Mac Gillavry, Marinus H. J. van Oers, Henk M. Lokhorst, Andries C. Bloem, Hans Clevers, Roel Nusse, Ronald van der Neut, Marcel Spaargaren, and Steven T. Pals

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
PNAS 2004 101: 6122-6127; published online before print April 5 2004, 10.1073/pnas.0305855101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Robert J. Binder and Pramod K. Srivastava

Essential role of CD91 in re-presentation of gp96-chaperoned peptides
PNAS 2004 101: 6128-6133; published online before print April 8 2004, 10.1073/pnas.0308180101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Chengguo Xing, Jacob R. LaPorte, Joseph K. Barbay, and Andrew G. Myers

Identification of GAPDH as a protein target of the saframycin antiproliferative agents
PNAS 2004 101: 5862-5866; published online before print April 12 2004, 10.1073/pnas.0307476101 [Abstract] [Full Text] [PDF]  

Ryan Jensen and Peter M. Glazer

Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions
PNAS 2004 101: 6134-6139; published online before print April 6 2004, 10.1073/pnas.0400051101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Cory L. Grand, Tiffanie J. Powell, Raymond B. Nagle, David J. Bearss, Denise Tye, Mary Gleason-Guzman, and Laurence H. Hurley

Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue
PNAS 2004 101: 6140-6145; published online before print April 12 2004, 10.1073/pnas.0400460101 [Abstract] [Full Text] [PDF]  

Christophe Fraser, Steven Riley, Roy M. Anderson, and Neil M. Ferguson

Factors that make an infectious disease outbreak controllable
PNAS 2004 101: 6146-6151; published online before print April 7 2004, 10.1073/pnas.0307506101 [Abstract] [Full Text] [PDF]  

Marc Lecuit, D. Michael Nelson, Steve D. Smith, Huot Khun, Michel Huerre, Marie-Cécile Vacher-Lavenu, Jeffrey I. Gordon, and Pascale Cossart

Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: Role of internalin interaction with trophoblast E-cadherin
PNAS 2004 101: 6152-6157; published online before print April 8 2004, 10.1073/pnas.0401434101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Attila Mócsai, Mary Beth Humphrey, Jessica A. G. Van Ziffle, Yongmei Hu, Andrew Burghardt, Steven C. Spusta, Sharmila Majumdar, Lewis L. Lanier, Clifford A. Lowell, and Mary C. Nakamura

The immunomodulatory adapter proteins DAP12 and Fc receptor -chain (FcR) regulate development of functional osteoclasts through the Syk tyrosine kinase
PNAS 2004 101: 6158-6163; published online before print April 8 2004, 10.1073/pnas.0401602101 [Abstract] [Full Text] [PDF] [Supporting Methods]  

Alexander Egle, Alan W. Harris, Philippe Bouillet, and Suzanne Cory

Bim is a suppressor of Myc-induced mouse B cell leukemia
PNAS 2004 101: 6164-6169; published online before print April 12 2004, 10.1073/pnas.0401471101 [Abstract] [Full Text] [PDF]  

E. Robert McDonald, III and Wafik S. El-Deiry

Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth
PNAS 2004 101: 6170-6175; published online before print April 6 2004, 10.1073/pnas.0307459101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Paul W. Lepp, Mary M. Brinig, Cleber C. Ouverney, Katherine Palm, Gary C. Armitage, and David A. Relman

Methanogenic Archaea and human periodontal disease
PNAS 2004 101: 6176-6181; published online before print April 5 2004, 10.1073/pnas.0308766101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Samuel Karlin, Julie Theriot, and Jan Mrázek

Comparative analysis of gene expression among low G+C gram-positive genomes
PNAS 2004 101: 6182-6187; published online before print April 6 2004, 10.1073/pnas.0401504101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

George T. Mercier, Jacquelyn A. Campbell, James D. Chappell, Thilo Stehle, Terence S. Dermody, and Michael A. Barry

A chimeric adenovirus vector encoding reovirus attachment protein 1 targets cells expressing junctional adhesion molecule 1
PNAS 2004 101: 6188-6193; published online before print April 12 2004, 10.1073/pnas.0400542101 [Abstract] [Full Text] [PDF]  

Bernard Clantin, Hélène Hodak, Eve Willery, Camille Locht, Françoise Jacob-Dubuisson, and Vincent Villeret

The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway
PNAS 2004 101: 6194-6199; published online before print April 12 2004, 10.1073/pnas.0400291101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Nicola J. Philpott, Marcelo Nociari, Keith B. Elkon, and Erik Falck-Pedersen

Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF- induction pathway
PNAS 2004 101: 6200-6205; published online before print April 7 2004, 10.1073/pnas.0308368101 [Abstract] [Full Text] [PDF]  

Gabriella Pessi, Guillermo Kociubinski, and Choukri Ben Mamoun

A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation
PNAS 2004 101: 6206-6211; published online before print April 8 2004, 10.1073/pnas.0307742101 [Abstract] [Full Text] [PDF]  

Ron A. M. Fouchier, Nico G. Hartwig, Theo M. Bestebroer, Berend Niemeyer, Jan C. de Jong, James H. Simon, and Albert D. M. E. Osterhaus

A previously undescribed coronavirus associated with respiratory disease in humans
PNAS 2004 101: 6212-6216; published online before print April 8 2004, 10.1073/pnas.0400762101 [Abstract] [Full Text] [PDF]  

Neuroscience

Denise Teves, Tom O. Videen, Philip E. Cryer, and William J. Powers

Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia
PNAS 2004 101: 6217-6221; published online before print March 16 2004, 10.1073/pnas.0307048101 [Abstract] [Full Text] [PDF]  

Graziano Pinna, Erminio Costa, and Alessandro Guidotti

Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids
PNAS 2004 101: 6222-6225; published online before print April 6 2004, 10.1073/pnas.0401479101 [Abstract] [Full Text] [PDF]  

A. W. Harrington, B. Leiner, C. Blechschmitt, J. C. Arevalo, R. Lee, K. Mörl, M. Meyer, B. L. Hempstead, S. O. Yoon, and K. M. Giehl From The Cover: Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury PNAS 2004 101: 6226-6230; published online before print March 16 2004, 10.1073/pnas.0305755101 [Abstract] [Full Text] [PDF]   See Commentary on page 5703

Martin Sládek, Alena Sumová, Zuzana Kováciková, Zdenka Bendová, Kristyna Laurinová, and Helena Illnerová

Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus
PNAS 2004 101: 6231-6236; published online before print April 6 2004, 10.1073/pnas.0401149101 [Abstract] [Full Text] [PDF]  

Jeffrey R. Gingrich, Kenneth A. Pelkey, Sami R. Fam, Yueqiao Huang, Ronald S. Petralia, Robert J. Wenthold, and Michael W. Salter

Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2
PNAS 2004 101: 6237-6242; published online before print April 6 2004, 10.1073/pnas.0401413101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hongxue Cai, Brett Shoelson, and Richard S. Chadwick

Evidence of tectorial membrane radial motion in a propagating mode of a complex cochlear model
PNAS 2004 101: 6243-6248; published online before print April 5 2004, 10.1073/pnas.0401395101 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Motoyuki Hirasawa, Toshio Ohshima, Satoru Takahashi, Glenn Longenecker, Yasuyuki Honjo, Veeranna, Harish C. Pant, Katsuhiko Miko