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COMMENTARIES

Dingzhi Wang and Raymond N. DuBois

Cyclooxygenase 2-derived prostaglandin E₂ regulates the angiogenic switch
PNAS 2004 101: 415-416; published online before print January 5 2004, 10.1073/pnas.0307640100 [Extract] [Full Text] [PDF]  
See companion article on page 591

Marilyn D. Resh

A myristoyl switch regulates membrane binding of HIV-1 Gag
PNAS 2004 101: 417-418; published online before print January 5 2004, 10.1073/pnas.0308043101 [Extract] [Full Text] [PDF]  
See companion article on page 517

PHYSICAL SCIENCES

Chemistry

J. Catalán, P. Pérez, J. C. del Valle, J. L. G. de Paz, and M. Kasha

H-bonded N-heterocyclic base-pair phototautomerizational potential barrier and mechanism: The 7-azaindole dimer
PNAS 2004 101: 419-422; published online before print December 30 2003, 10.1073/pnas.0306721101 [Abstract] [Full Text] [PDF]  

Geophysics

James Hansen and Larissa Nazarenko

Soot climate forcing via snow and ice albedos
PNAS 2004 101: 423-428; published online before print December 29 2003, 10.1073/pnas.2237157100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Physics

Tae-Woo Lee, Jana Zaumseil, Zhenan Bao, Julia W. P. Hsu, and John A. Rogers

Organic light-emitting diodes formed by soft contact lamination
PNAS 2004 101: 429-433; published online before print January 2 2004, 10.1073/pnas.0304179101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Biochemistry

Maki Inada and Christine Guthrie

Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs
PNAS 2004 101: 434-439; published online before print January 2 2004, 10.1073/pnas.0307425100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Lei Shi and Jonathan A. Javitch

The second extracellular loop of the dopamine D₂ receptor lines the binding-site crevice
PNAS 2004 101: 440-445; published online before print January 2 2004, 10.1073/pnas.2237265100 [Abstract] [Full Text] [PDF]  

Vitali Svetlitchnyi, Holger Dobbek, Wolfram Meyer-Klaucke, Thomas Meins, Bärbel Thiele, Piero Römer, Robert Huber, and Ortwin Meyer

A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans
PNAS 2004 101: 446-451; published online before print December 29 2003, 10.1073/pnas.0304262101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Silvia Ayora, Begoña Carrasco, Ernesto Doncel, Rudi Lurz, and Juan C. Alonso

Bacillus subtilis RecU protein cleaves Holliday junctions and anneals single-stranded DNA
PNAS 2004 101: 452-457; published online before print December 30 2003, 10.1073/pnas.2533829100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Joseph Ziegelbauer, Joyce Wei, and Robert Tjian

Myc-interacting protein 1 target gene profile: A link to microtubules, extracellular signal-regulated kinase, and cell growth
PNAS 2004 101: 458-463; published online before print January 2 2004, 10.1073/pnas.0307562100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Eugenia Cifuentes, Jennifer M. Mataraza, Barbara A. Yoshida, Mani Menon, David B. Sacks, Evelyn R. Barrack, and G. Prem-Veer Reddy

Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells
PNAS 2004 101: 464-469; published online before print December 26 2003, 10.1073/pnas.0307161101 [Abstract] [Full Text] [PDF]  

Evy Vierstraete, Peter Verleyen, Geert Baggerman, Wannes D'Hertog, Gert Van den Bergh, Lutgarde Arckens, Arnold De Loof, and Liliane Schoofs From the Cover: A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph PNAS 2004 101: 470-475; published online before print January 5 2004, 10.1073/pnas.0304567101 [Abstract] [Full Text] [PDF]

Danielle L. Letting, Ying-Yu Chen, Carrie Rakowski, Sarah Reedy, and Gerd A. Blobel

Context-dependent regulation of GATA-1 by friend of GATA-1
PNAS 2004 101: 476-481; published online before print December 26 2003, 10.1073/pnas.0306315101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Amir Aharoni, Leonid Gaidukov, Shai Yagur, Lilly Toker, Israel Silman, and Dan S. Tawfik

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
PNAS 2004 101: 482-487; published online before print December 26 2003, 10.1073/pnas.2536901100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jong-Ik Hwang, Iain D. C. Fraser, Sangdun Choi, Xiao-Feng Qin, and Melvin I. Simon From the Cover: Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA PNAS 2004 101: 488-493; published online before print December 29 2003, 10.1073/pnas.0307549100 [Abstract] [Full Text] [PDF]

Li Lei, Michael R. Waterman, Armand J. Fulco, Steven L. Kelly, and David C. Lamb

Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2)
PNAS 2004 101: 494-499; published online before print January 2 2004, 10.1073/pnas.2435922100 [Abstract] [Full Text] [PDF]  

Hiroshi Manya, Atsuro Chiba, Aruto Yoshida, Xiaohui Wang, Yasunori Chiba, Yoshifumi Jigami, Richard U. Margolis, and Tamao Endo

Demonstration of mammalian protein O-mannosyltransferase activity: Coexpression of POMT1 and POMT2 required for enzymatic activity
PNAS 2004 101: 500-505; published online before print December 29 2003, 10.1073/pnas.0307228101 [Abstract] [Full Text] [PDF]  

Biophysics

Andrew Moran and Shaul Mukamel

The origin of vibrational mode couplings in various secondary structural motifs of polypeptides
PNAS 2004 101: 506-510; published online before print January 2 2004, 10.1073/pnas.2533089100 [Abstract] [Full Text] [PDF]  

Yaakov Levy, Peter G. Wolynes, and José N. Onuchic

Protein topology determines binding mechanism
PNAS 2004 101: 511-516; published online before print December 23 2003, 10.1073/pnas.2534828100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chun Tang, Erin Loeliger, Paz Luncsford, Isaac Kinde, Dorothy Beckett, and Michael F. Summers From the Cover: Entropic switch regulates myristate exposure in the HIV-1 matrix protein PNAS 2004 101: 517-522; published online before print December 29 2003, 10.1073/pnas.0305665101 [Abstract] [Full Text] [PDF] [Supporting Figure]   See Commentary on page 417

Zoya Ignatova and Lila M. Gierasch

Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling
PNAS 2004 101: 523-528; published online before print December 30 2003, 10.1073/pnas.0304533101 [Abstract] [Full Text] [PDF]  

Dmitry Bloch, Ilya Belevich, Audrius Jasaitis, Camilla Ribacka, Anne Puustinen, Michael I. Verkhovsky, and Mårten Wikström

The catalytic cycle of cytochrome c oxidase is not the sum of its two halves
PNAS 2004 101: 529-533; published online before print December 29 2003, 10.1073/pnas.0306036101 [Abstract] [Full Text] [PDF]  

Zheng Xie, Narayanan Srividya, Tobin R. Sosnick, Tao Pan, and Norbert F. Scherer

Single-molecule studies highlight conformational heterogeneity in the early folding steps of a large ribozyme
PNAS 2004 101: 534-539; published online before print January 2 2004, 10.1073/pnas.2636333100 [Abstract] [Full Text] [PDF]  

Cell Biology

Constantine S. Mitsiades, Nicholas S. Mitsiades, Ciaran J. McMullan, Vassiliki Poulaki, Reshma Shringarpure, Teru Hideshima, Masaharu Akiyama, Dharminder Chauhan, Nikhil Munshi, Xuesong Gu, Charles Bailey, Marie Joseph, Towia A. Libermann, Victoria M. Richon, Paul A. Marks, and Kenneth C. Anderson

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications
PNAS 2004 101: 540-545; published online before print December 26 2003, 10.1073/pnas.2536759100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sang Yoon Lee, Markus R. Wenk, Yong Kim, Angus C. Nairn, and Pietro De Camilli

Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses
PNAS 2004 101: 546-551; published online before print January 2 2004, 10.1073/pnas.0307813100 [Abstract] [Full Text] [PDF]  

Christopher L. Tinkle, Terry Lechler, H. Amalia Pasolli, and Elaine Fuchs

Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses
PNAS 2004 101: 552-557; published online before print January 2 2004, 10.1073/pnas.0307437100 [Abstract] [Full Text] [PDF]  

Ecology

David M. Nelson, Feng Sheng Hu, Jian Tian, Ivanka Stefanova, and Thomas A. Brown

Response of C₃ and C₄ plants to middle-Holocene climatic variation near the prairie–forest ecotone of Minnesota
PNAS 2004 101: 562-567; published online before print December 30 2003, 10.1073/pnas.0307450100 [Abstract] [Full Text] [PDF]  

Evolution

Anne Rantala, David P. Fewer, Michael Hisbergues, Leo Rouhiainen, Jaana Vaitomaa, Thomas Börner, and Kaarina Sivonen

Phylogenetic evidence for the early evolution of microcystin synthesis
PNAS 2004 101: 568-573; published online before print December 30 2003, 10.1073/pnas.0304489101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Genetics

N. A. C. S. Wong, M. P. Britton, G. S. Choi, T. K. Stanton, D. C. Bicknell, J. L. Wilding, and W. F. Bodmer

Loss of CDX1 expression in colorectal carcinoma: Promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines
PNAS 2004 101: 574-579; published online before print January 2 2004, 10.1073/pnas.0307190101 [Abstract] [Full Text] [PDF]  

Paul François and Vincent Hakim

Design of genetic networks with specified functions by evolution in silico
PNAS 2004 101: 580-585; published online before print January 2 2004, 10.1073/pnas.0304532101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Margaret M. Mentink-Kane, Allen W. Cheever, Robert W. Thompson, Danielle M. Hari, Narcis B. Kabatereine, Birgitte J. Vennervald, John H. Ouma, Joseph K. Mwatha, Frances M. Jones, Debra D. Donaldson, Michael J. Grusby, David W. Dunne, and Thomas A. Wynn

IL-13 receptor 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis
PNAS 2004 101: 586-590; published online before print December 29 2003, 10.1073/pnas.0305064101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Benjamin S. Braun, David A. Tuveson, Namie Kong, Doan T. Le, Scott C. Kogan, Jacob Rozmus, Michelle M. Le Beau, Tyler E. Jacks, and Kevin M. Shannon

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
PNAS 2004 101: 597-602; published online before print December 29 2003, 10.1073/pnas.0307203101 [Abstract] [Full Text] [PDF]  

A. J. T. Schuldt, T. J. Hampton, V. Chu, C. A. Vogler, N. Galvin, M. D. Lessard, and J. E. Barker

Electrocardiographic and other cardiac anomalies in -glucuronidase-null mice corrected by nonablative neonatal marrow transplantation
PNAS 2004 101: 603-608; published online before print January 2 2004, 10.1073/pnas.0305284101 [Abstract] [Full Text] [PDF]  

Jay Y. Cho, Changsheng Guo, Monica Torello, Gregory P. Lunstrum, Tomoko Iwata, Chuxia Deng, and William A. Horton

Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia
PNAS 2004 101: 609-614; published online before print December 29 2003, 10.1073/pnas.2237184100 [Abstract] [Full Text] [PDF]  

Robert O. Stuart, William Wachsman, Charles C. Berry, Jessica Wang-Rodriguez, Linda Wasserman, Igor Klacansky, Dan Masys, Karen Arden, Steven Goodison, Michael McClelland, Yipeng Wang, Anne Sawyers, Iveta Kalcheva, David Tarin, and Dan Mercola

In silico dissection of cell-type-associated patterns of gene expression in prostate cancer
PNAS 2004 101: 615-620. [Abstract] [Full Text] [PDF] [Supporting Information]  

Xu Song, Aiwei Sui, and Alan Garen

Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: Effects on steroidogenesis and oncogenesis
PNAS 2004 101: 621-626; published online before print January 2 2004, 10.1073/pnas.0307794100 [Abstract] [Full Text] [PDF]  

Microbiology

Xibing Li and Saul Roseman

The chitinolytic cascade in Vibrios is regulated by chitin oligosaccharides and a two-component chitin catabolic sensor/kinase
PNAS 2004 101: 627-631; published online before print December 29 2003, 10.1073/pnas.0307645100 [Abstract] [Full Text] [PDF]  

Que Dang, Jianbo Chen, Derya Unutmaz, John M. Coffin, Vinay K. Pathak, Douglas Powell, Vineet N. KewalRamani, Frank Maldarelli, and Wei-Shau Hu

Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways
PNAS 2004 101: 632-637; published online before print January 5 2004, 10.1073/pnas.0307636100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Jesse Summers and William S. Mason

Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy
PNAS 2004 101: 638-640; published online before print December 29 2003, 10.1073/pnas.0307422100 [Abstract] [Full Text] [PDF]  

Katy C. Kao, Young-Lyeol Yang, Riccardo Boscolo, Chiara Sabatti, Vwani Roychowdhury, and James C. Liao

Transcriptome-based determination of multiple transcription regulator activities in Escherichia coli by using network component analysis
PNAS 2004 101: 641-646; published online before print December 23 2003, 10.1073/pnas.0305287101 [Abstract] [Full Text] [PDF]  

Neuroscience

Huiwu Li, Xiujing Gu, Valina L. Dawson, and Ted M. Dawson

Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE)
PNAS 2004 101: 647-652; published online before print December 30 2003, 10.1073/pnas.0305145101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Yasuo Ido, Katherine Chang, and Joseph R. Williamson

NADH augments blood flow in physiologically activated retina and visual cortex
PNAS 2004 101: 653-658; published online before print January 2 2004, 10.1073/pnas.0307458100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mark A. Mintun, Andrei G. Vlassenko, Melissa M. Rundle, and Marcus E. Raichle

Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain
PNAS 2004 101: 659-664; published online before print January 2 2004, 10.1073/pnas.0307457100 [Abstract] [Full Text] [PDF]  

Stéphane Hunot, Miquel Vila, Peter Teismann, Roger J. Davis, Etienne C. Hirsch, Serge Przedborski, Pasko Rakic, and Richard A. Flavell

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease
PNAS 2004 101: 665-670; published online before print January 2 2004, 10.1073/pnas.0307453101 [Abstract] [Full Text] [PDF] [Supporting Information]  

F. Lesage, H. Hibino, and A. J. Hudspeth

Association of -catenin with the -subunit of neuronal large-conductance Ca²⁺-activated K+ channels
PNAS 2004 101: 671-675; published online before print December 30 2003, 10.1073/pnas.0307681100 [Abstract] [Full Text] [PDF]  

T. Launey, S. Endo, R. Sakai, J. Harano, and M. Ito

Protein phosphatase 2A inhibition induces cerebellar long-term depression and declustering of synaptic AMPA receptor
PNAS 2004 101: 676-681; published online before print December 29 2003, 10.1073/pnas.0302914101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Alejandro Martínez-Martínez, Jorge Mauricio Reyes-Ruiz, Ataúlfo Martínez-Torres, and Ricardo Miledi

Functional expression in frog oocytes of human 1 receptors produced in Saccharomyces cerevisiae
PNAS 2004 101: 682-686; published online before print January 2 2004, 10.1073/pnas.0307564100 [Abstract] [Full Text] [PDF]  

Plant Biology

Shunhong Dai, Zhihong Zhang, Shouyi Chen, and Roger N. Beachy

RF2b, a rice bZIP transcription activator, interacts with RF2a and is involved in symptom development of rice tungro disease
PNAS 2004 101: 687-692; published online before print January 2 2004, 10.1073/pnas.0307687100 [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for Vrana et al., Nonhuman primate parthenogenetic stem cells, PNAS 2003 100:11911-11916 [Extract] [Full Text] [PDF]