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COMMENTARIES

Catherine M. Joyce

T4 replication: What does "processivity" really mean?
PNAS 2004 101: 8255-8256; published online before print May 24 2004, 10.1073/pnas.0402850101 [Extract] [Full Text] [PDF]  
See companion article on page 8289

Luciano Brocchieri

Environmental signatures in proteome properties
PNAS 2004 101: 8257-8258; published online before print May 24 2004, 10.1073/pnas.0402797101 [Extract] [Full Text] [PDF]  
See companion article on page 8390

PHYSICAL SCIENCES

Chemistry

Williams G. Skene and Jean-Marie P. Lehn

Dynamers: Polyacylhydrazone reversible covalent polymers, component exchange, and constitutional diversity
PNAS 2004 101: 8270-8275; published online before print May 18 2004, 10.1073/pnas.0401885101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Damien Alcor, Vincent Croquette, Ludovic Jullien, and Annie Lemarchand

Molecular sorting by stochastic resonance
PNAS 2004 101: 8276-8280; published online before print May 20 2004, 10.1073/pnas.0400663101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geology

Benjamin P. Weiss, Soon Sam Kim, Joseph L. Kirschvink, Robert E. Kopp, Mohan Sankaran, Atsuko Kobayashi, and Arash Komeili

Magnetic tests for magnetosome chains in Martian meteorite ALH84001
PNAS 2004 101: 8281-8284; published online before print May 20 2004, 10.1073/pnas.0402292101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Applied Biological Sciences

Miro Smriga, Shibani Ghosh, Youssef Mouneimne, Peter L. Pellett, and Nevin S. Scrimshaw

Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria
PNAS 2004 101: 8285-8288; published online before print May 24 2004, 10.1073/pnas.0402550101 [Abstract] [Full Text] [PDF]  

Biochemistry

Nayden Koon, Christopher J. Squire, and Edward N. Baker

Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis
PNAS 2004 101: 8295-8300; published online before print May 24 2004, 10.1073/pnas.0400820101 [Abstract] [Full Text] [PDF]  

Richard L. Kingston, Damon J. Hamel, Leslie S. Gay, Frederick W. Dahlquist, and Brian W. Matthews

Structural basis for the attachment of a paramyxoviral polymerase to its template
PNAS 2004 101: 8301-8306; published online before print May 24 2004, 10.1073/pnas.0402690101 [Abstract] [Full Text] [PDF]  

Haihong Wu, Anthony Henras, Guillaume Chanfreau, and Juli Feigon

Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III
PNAS 2004 101: 8307-8312; published online before print May 18 2004, 10.1073/pnas.0402627101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Masanari Matsumoto, Takashi Miki, Tadao Shibasaki, Miho Kawaguchi, Hidehiro Shinozaki, Junko Nio, Atsunori Saraya, Haruhiko Koseki, Masaru Miyazaki, Toshihiko Iwanaga, and Susumu Seino

Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells
PNAS 2004 101: 8313-8318; published online before print May 24 2004, 10.1073/pnas.0306709101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Gabriela da Silva Xavier, Jared Rutter, and Guy A. Rutter

Involvement of Per–Arnt–Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose
PNAS 2004 101: 8319-8324; published online before print May 17 2004, 10.1073/pnas.0307737101 [Abstract] [Full Text] [PDF]  

Kristine B. Arnvig, S. Pennell, B. Gopal, and M. J. Colston

A high-affinity interaction between NusA and the rrn nut site in Mycobacterium tuberculosis
PNAS 2004 101: 8325-8330; published online before print May 24 2004, 10.1073/pnas.0401287101 [Abstract] [Full Text] [PDF]  

Biophysics

Yongli Zhang, Zhiqun Xi, Rashmi S. Hegde, Zippora Shakked, and Donald M. Crothers

Predicting indirect readout effects in protein–DNA interactions
PNAS 2004 101: 8337-8341; published online before print May 17 2004, 10.1073/pnas.0402319101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Cédric Govaerts, Holger Wille, Stanley B. Prusiner, and Fred E. Cohen

Evidence for assembly of prions with left-handed -helices into trimers
PNAS 2004 101: 8342-8347; published online before print May 21 2004, 10.1073/pnas.0402254101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Beili Wu, Pengyun Li, Yiwei Liu, Zhiyong Lou, Yi Ding, Cuiling Shu, Sheng Ye, Mark Bartlam, Beifen Shen, and Zihe Rao

3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex
PNAS 2004 101: 8348-8353; published online before print May 24 2004, 10.1073/pnas.0305969101 [Abstract] [Full Text] [PDF]  

Isaac A. Hubner, Mikael Oliveberg, and Eugene I. Shakhnovich

Simulation, experiment, and evolution: Understanding nucleation in protein S6 folding
PNAS 2004 101: 8354-8359; published online before print May 18 2004, 10.1073/pnas.0401672101 [Abstract] [Full Text] [PDF]  

Cell Biology

Markus R. Wenk and Pietro De Camilli Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: Insights from vesicle recycling in nerve terminals PNAS 2004 101: 8262-8269; published online before print May 14 2004, 10.1073/pnas.0401874101 [Abstract] [Full Text] [PDF]

Hélène Strick-Marchand, Serban Morosan, Pierre Charneau, Dina Kremsdorf, and Mary C. Weiss

Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes
PNAS 2004 101: 8360-8365; published online before print May 20 2004, 10.1073/pnas.0401092101 [Abstract] [Full Text] [PDF]  

Joel Abramowitz, Dagoberto Grenet, Mariel Birnbaumer, Hector N. Torres, and Lutz Birnbaumer

XLs, the extra-long form of the -subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex
PNAS 2004 101: 8366-8371; published online before print May 17 2004, 10.1073/pnas.0308758101 [Abstract] [Full Text] [PDF]  

Sharon C. Braunagel, Shawn T. Williamson, Suraj Saksena, Zhenping Zhong, William K. Russell, David H. Russell, and Max D. Summers

Trafficking of ODV-E66 is mediated via a sorting motif and other viral proteins: Facilitated trafficking to the inner nuclear membrane
PNAS 2004 101: 8372-8377; published online before print May 18 2004, 10.1073/pnas.0402727101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Developmental Biology

Haiwei Pi, Shao-Kuei Huang, Chiou-Yang Tang, Y. Henry Sun, and Cheng-Ting Chien

phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development
PNAS 2004 101: 8378-8383; published online before print May 17 2004, 10.1073/pnas.0306010101 [Abstract] [Full Text] [PDF]  

Robert M. Bachoo, Ryung S. Kim, Keith L. Ligon, Elizabeth A. Maher, Cameron Brennan, Nathan Billings, Suzanne Chan, Cheng Li, David H. Rowitch, Wing H. Wong, and Ronald A. DePinho

Molecular diversity of astrocytes with implications for neurological disorders
PNAS 2004 101: 8384-8389; published online before print May 21 2004, 10.1073/pnas.0402140101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Evolution

Rafael Sanjuán, Andrés Moya, and Santiago F. Elena

The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus
PNAS 2004 101: 8396-8401; published online before print May 24 2004, 10.1073/pnas.0400146101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Genetics

Diego Lorenzetti, Colin E. Bishop, and Monica J. Justice

Deletion of the Parkin coregulated gene causes male sterility in the quaking^viable mouse mutant
PNAS 2004 101: 8402-8407; published online before print May 17 2004, 10.1073/pnas.0401832101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Jessica M. Girard, David M. Wagner, Amy J. Vogler, Christine Keys, Christopher J. Allender, Lee C. Drickamer, and Paul Keim From The Cover: Differential plague-transmission dynamics determine Yersinia pestis population genetic structure on local, regional, and global scales PNAS 2004 101: 8408-8413; published online before print May 20 2004, 10.1073/pnas.0401561101 [Abstract] [Full Text] [PDF] [Supporting Information]

Hideki Kobayashi, Mads Kærn, Michihiro Araki, Kristy Chung, Timothy S. Gardner, Charles R. Cantor, and James J. Collins

Programmable cells: Interfacing natural and engineered gene networks
PNAS 2004 101: 8414-8419; published online before print May 24 2004, 10.1073/pnas.0402940101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Mats Gullberg, Sigrún M. Gústafsdóttir, Edith Schallmeiner, Jonas Jarvius, Mattias Bjarnegård, Christer Betsholtz, Ulf Landegren, and Simon Fredriksson

Cytokine detection by antibody-based proximity ligation
PNAS 2004 101: 8420-8424; published online before print May 21 2004, 10.1073/pnas.0400552101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Medical Sciences

Yun-Ping Wu and Richard L. Proia

Deletion of macrophage-inflammatory protein 1 retards neurodegeneration in Sandhoff disease mice
PNAS 2004 101: 8425-8430; published online before print May 20 2004, 10.1073/pnas.0400625101 [Abstract] [Full Text] [PDF]  

Jennifer Pittman, Erich Huang, Holly Dressman, Cheng-Fang Horng, Skye H. Cheng, Mei-Hua Tsou, Chii-Ming Chen, Andrea Bild, Edwin S. Iversen, Andrew T. Huang, Joseph R. Nevins, and Mike West

Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes
PNAS 2004 101: 8431-8436; published online before print May 19 2004, 10.1073/pnas.0401736101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Göran Leonardsson, Jenny H. Steel, Mark Christian, Victoria Pocock, Stuart Milligan, Jimmy Bell, Po-Wah So, Gema Medina-Gomez, Antonio Vidal-Puig, Roger White, and Malcolm G. Parker

Nuclear receptor corepressor RIP140 regulates fat accumulation
PNAS 2004 101: 8437-8442; published online before print May 20 2004, 10.1073/pnas.0401013101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Shinobu Tsuzuki, Masao Seto, Mel Greaves, and Tariq Enver

Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice
PNAS 2004 101: 8443-8448; published online before print May 20 2004, 10.1073/pnas.0402063101 [Abstract] [Full Text] [PDF]  

Microbiology

Benjamin P. Weiss, Soon Sam Kim, Joseph L. Kirschvink, Robert E. Kopp, Mohan Sankaran, Atsuko Kobayashi, and Arash Komeili

Magnetic tests for magnetosome chains in Martian meteorite ALH84001
PNAS 2004 101: 8281-8284; published online before print May 20 2004, 10.1073/pnas.0402292101 [Abstract] [Full Text] [PDF]  

Alex R. Hoffmaster, Jacques Ravel, David A. Rasko, Gail D. Chapman, Michael D. Chute, Chung K. Marston, Barun K. De, Claudio T. Sacchi, Collette Fitzgerald, Leonard W. Mayer, Martin C. J. Maiden, Fergus G. Priest, Margaret Barker, Lingxia Jiang, Regina Z. Cer, Jennifer Rilstone, Scott N. Peterson, Robbin S. Weyant, Darrell R. Galloway, Timothy D. Read, Tanja Popovic, and Claire M. Fraser

Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax
PNAS 2004 101: 8449-8454; published online before print May 21 2004, 10.1073/pnas.0402414101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Berend Jan Bosch, Byron E. E. Martina, Ruurd van der Zee, Jean Lepault, Bert Jan Haijema, Cees Versluis, Albert J. R. Heck, Raoul de Groot, Albert D. M. E. Osterhaus, and Peter J. M. Rottier

Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides
PNAS 2004 101: 8455-8460; published online before print May 18 2004, 10.1073/pnas.0400576101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neuroscience

Joseph Carroll, Maureen Neitz, Heidi Hofer, Jay Neitz, and David R. Williams

Functional photoreceptor loss revealed with adaptive optics: An alternate cause of color blindness
PNAS 2004 101: 8461-8466; published online before print May 17 2004, 10.1073/pnas.0401440101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Mark E. Jackson, Houman Homayoun, and Bita Moghaddam

NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
PNAS 2004 101: 8467-8472; published online before print May 24 2004, 10.1073/pnas.0308455101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Raffaella Molteni, Jun-Qi Zheng, Zhe Ying, Fernando Gómez-Pinilla, and Jeffery L. Twiss

Voluntary exercise increases axonal regeneration from sensory neurons
PNAS 2004 101: 8473-8478; published online before print May 24 2004, 10.1073/pnas.0401443101 [Abstract] [Full Text] [PDF]  

Tatsuro Kumada and Hitoshi Komuro

Completion of neuronal migration regulated by loss of Ca²⁺ transients
PNAS 2004 101: 8479-8484; published online before print May 18 2004, 10.1073/pnas.0401000101 [Abstract] [Full Text] [PDF]  

Guochuan Tsai, Rebecca J. Ralph-Williams, Marzia Martina, Richard Bergeron, Joanne Berger-Sweeney, Kevin S. Dunham, Zhichun Jiang, S. Barak Caine, and Joseph T. Coyle

Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype
PNAS 2004 101: 8485-8490; published online before print May 24 2004, 10.1073/pnas.0402662101 [Abstract] [Full Text] [PDF]  

Pranab K. Mukherjee, Victor L. Marcheselli, Charles N. Serhan, and Nicolas G. Bazan From The Cover: Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress PNAS 2004 101: 8491-8496; published online before print May 19 2004, 10.1073/pnas.0402531101 [Abstract] [Full Text] [PDF]

Pharmacology

Ennio Ongini, Francesco Impagnatiello, Albino Bonazzi, Massimiliano Guzzetta, Mirco Govoni, Angela Monopoli, Piero Del Soldato, and Louis J. Ignarro

Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties
PNAS 2004 101: 8497-8502. [Abstract] [Full Text] [PDF]  

Physiology

Pauline M. Anton, Jerome Gay, Andreas Mykoniatis, Amy Pan, Michael O'Brien, Daniel Brown, Katia Karalis, and Charalabos Pothoulakis

Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation
PNAS 2004 101: 8503-8508; published online before print May 24 2004, 10.1073/pnas.0402693101 [Abstract] [Full Text] [PDF]