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COMMENTARIES

Thomas J. Klein and Marek Mlodzik

A conserved signaling cassette regulates hair patterning from Drosophila to man
PNAS 2004 101: 9173-9174; published online before print June 15 2004, 10.1073/pnas.0403301101 [Extract] [Full Text] [PDF]  
See companion article on page 9277

Adam M. Breier and Nicholas R. Cozzarelli

Linear ordering and dynamic segregation of the bacterial chromosome
PNAS 2004 101: 9175-9176; published online before print June 15 2004, 10.1073/pnas.0403722101 [Extract] [Full Text] [PDF]  
See companion article on page 9257

Dietmar Kültz

Hyperosmolality triggers oxidative damage in kidney cells
PNAS 2004 101: 9177-9178; published online before print June 15 2004, 10.1073/pnas.0403241101 [Extract] [Full Text] [PDF]  
See companion article on page 9491

PHYSICAL SCIENCES

Applied Physical Sciences

Astronomy

Uwe J. Meierhenrich, Guillermo M. Muñoz Caro, Jan Hendrik Bredehöft, Elmar K. Jessberger, and Wolfram H.-P. Thiemann

Identification of diamino acids in the Murchison meteorite
PNAS 2004 101: 9182-9186; published online before print June 11 2004, 10.1073/pnas.0403043101 [Abstract] [Full Text] [PDF]  

Geology

Thibault de Garidel-Thoron, Luc Beaufort, Franck Bassinot, and Pierre Henry

Evidence for large methane releases to the atmosphere from deep-sea gas-hydrate dissociation during the last glacial episode
PNAS 2004 101: 9187-9192; published online before print June 14 2004, 10.1073/pnas.0402909101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Applied Biological Sciences

Barrett R. Harvey, George Georgiou, Andrew Hayhurst, Ki Jun Jeong, Brent L. Iverson, and Geoffrey K. Rogers

Anchored periplasmic expression, a versatile technology for the isolation of high-affinity antibodies from Escherichia coli-expressed libraries
PNAS 2004 101: 9193-9198; published online before print June 14 2004, 10.1073/pnas.0400187101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Biochemistry

Michio Asahi, Kinya Otsu, Hiroyuki Nakayama, Shungo Hikoso, Toshihiro Takeda, Anthony O. Gramolini, Maria G. Trivieri, Gavin Y. Oudit, Takashi Morita, Yoichiro Kusakari, Shuta Hirano, Kenichi Hongo, Shinichi Hirotani, Osamu Yamaguchi, Alan Peterson, Peter H. Backx, Satoshi Kurihara, Masatsugu Hori, and David H. MacLennan

Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca²⁺ ATPase (SERCA2a) activity and impairs cardiac function in mice
PNAS 2004 101: 9199-9204; published online before print June 16 2004, 10.1073/pnas.0402596101 [Abstract] [Full Text] [PDF]  

Haiwei H. Guo, Juno Choe, and Lawrence A. Loeb

Protein tolerance to random amino acid change
PNAS 2004 101: 9205-9210; published online before print June 14 2004, 10.1073/pnas.0403255101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Xunqing Jiang and Joel G. Belasco

Catalytic activation of multimeric RNase E and RNase G by 5'-monophosphorylated RNA
PNAS 2004 101: 9211-9216; published online before print June 14 2004, 10.1073/pnas.0401382101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

David L. Waning, Charles J. Russell, Theodore S. Jardetzky, and Robert A. Lamb

Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail
PNAS 2004 101: 9217-9222; published online before print June 14 2004, 10.1073/pnas.0403339101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Biophysics

C. Kiel, T. Selzer, Y. Shaul, G. Schreiber, and C. Herrmann

Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex
PNAS 2004 101: 9223-9228; published online before print June 14 2004, 10.1073/pnas.0401160101 [Abstract] [Full Text] [PDF] [Supporting Information]  

S. Gnanakaran, Robin M. Hochstrasser, and Angel E. García

Nature of structural inhomogeneities on folding a helix and their influence on spectral measurements
PNAS 2004 101: 9229-9234; published online before print June 14 2004, 10.1073/pnas.0402933101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Ronald P. White and Hagai Meirovitch

A simulation method for calculating the absolute entropy and free energy of fluids: Application to liquid argon and water
PNAS 2004 101: 9235-9240; published online before print June 14 2004, 10.1073/pnas.0308197101 [Abstract] [Full Text] [PDF]  

Srinath Cheluvaraja and Hagai Meirovitch

Simulation method for calculating the entropy and free energy of peptides and proteins
PNAS 2004 101: 9241-9246; published online before print June 14 2004, 10.1073/pnas.0308201101 [Abstract] [Full Text] [PDF]  

Alan Garfinkel, Yin Tintut, Danny Petrasek, Kristina Boström, and Linda L. Demer

Pattern formation by vascular mesenchymal cells
PNAS 2004 101: 9247-9250; published online before print June 14 2004, 10.1073/pnas.0308436101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cell Biology

Sherry C. Wang and Lucy Shapiro

The topoisomerase IV ParC subunit colocalizes with the Caulobacter replisome and is required for polar localization of replication origins
PNAS 2004 101: 9251-9256; published online before print June 3 2004, 10.1073/pnas.0402567101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Patrick H. Viollier, Martin Thanbichler, Patrick T. McGrath, Lisandra West, Maliwan Meewan, Harley H. McAdams, and Lucy Shapiro From The Cover: Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication PNAS 2004 101: 9257-9262; published online before print June 3 2004, 10.1073/pnas.0402606101 [Abstract] [Full Text] [PDF] [Supporting Information]   See Commentary on page 9175

Pauline Lee, Hongfan Peng, Terri Gelbart, and Ernest Beutler

The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and ₂-microglobulin-deficient hepatocytes
PNAS 2004 101: 9263-9265; published online before print June 10 2004, 10.1073/pnas.0403108101 [Abstract] [Full Text] [PDF]  

Li Ma, Vytautas P. Bindokas, Andrey Kuznetsov, Christopher Rhodes, Lori Hays, J. Michael Edwardson, Kazuya Ueda, Donald F. Steiner, and Louis H. Philipson

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion
PNAS 2004 101: 9266-9271; published online before print June 14 2004, 10.1073/pnas.0403201101 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Robert Drakas, Xiao Tu, and Renato Baserga

Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase
PNAS 2004 101: 9272-9276; published online before print June 14 2004, 10.1073/pnas.0403328101 [Abstract] [Full Text] [PDF]  

Developmental Biology

Radhika R. Pochampally, Brian T. Neville, Emily J. Schwarz, Marilyn M. Li, and Darwin J. Prockop

Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion
PNAS 2004 101: 9282-9285; published online before print June 14 2004, 10.1073/pnas.0401558101 [Abstract] [Full Text] [PDF]  

Ecology

JoAnn Burkholder, David Eggleston, Howard Glasgow, Cavell Brownie, Robert Reed, Gerald Janowitz, Martin Posey, Greg Melia, Carol Kinder, Reide Corbett, David Toms, Troy Alphin, Nora Deamer, and Jeffrey Springer

Comparative impacts of two major hurricane seasons on the Neuse River and western Pamlico Sound ecosystems
PNAS 2004 101: 9291-9296; published online before print June 15 2004, 10.1073/pnas.0306842101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Anthony D. Barnosky, Christopher J. Bell, Steven D. Emslie, H. Thomas Goodwin, Jim I. Mead, Charles A. Repenning, Eric Scott, and Alan B. Shabel

Exceptional record of mid-Pleistocene vertebrates helps differentiate climatic from anthropogenic ecosystem perturbations
PNAS 2004 101: 9297-9302; published online before print June 14 2004, 10.1073/pnas.0402592101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Robert H. Devlin, Mark D'Andrade, Mitchell Uh, and Carlo A. Biagi

Population effects of growth hormone transgenic coho salmon depend on food availability and genotype by environment interactions
PNAS 2004 101: 9303-9308; published online before print June 10 2004, 10.1073/pnas.0400023101 [Abstract] [Full Text] [PDF]  

Genetics

Daniel R. Rhodes, Jianjun Yu, K. Shanker, Nandan Deshpande, Radhika Varambally, Debashis Ghosh, Terrence Barrette, Akhilesh Pandey, and Arul M. Chinnaiyan

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression
PNAS 2004 101: 9309-9314; published online before print June 7 2004, 10.1073/pnas.0401994101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Neal Sugawara, Tamara Goldfarb, Barbara Studamire, Eric Alani, and James E. Haber

Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1
PNAS 2004 101: 9315-9320; published online before print June 15 2004, 10.1073/pnas.0305749101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Terje Raudsepp, Avni Santani, Barbara Wallner, Srinivas R. Kata, Chengwei Ren, Hong-Bin Zhang, James E. Womack, Loren C. Skow, and Bhanu P. Chowdhary

A detailed physical map of the horse Y chromosome
PNAS 2004 101: 9321-9326; published online before print June 14 2004, 10.1073/pnas.0403011101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Aatur D. Singhi, Roman V. Kondratov, Nickolay Neznanov, Mikhail V. Chernov, and Andrei V. Gudkov

Selection–subtraction approach (SSA): A universal genetic screening technique that enables negative selection
PNAS 2004 101: 9327-9332; published online before print June 8 2004, 10.1073/pnas.0403080101 [Abstract] [Full Text] [PDF]  

Michael T. Hemann, Jack T. Zilfou, Zhen Zhao, Darren J. Burgess, Gregory J. Hannon, and Scott W. Lowe

Suppression of tumorigenesis by the p53 target PUMA
PNAS 2004 101: 9333-9338; published online before print June 10 2004, 10.1073/pnas.0403286101 [Abstract] [Full Text] [PDF]  

Immunology

Nami McCarty, Mari L. Shinohara, Linrong Lu, and Harvey Cantor

Detailed analysis of gene expression during development of T cell lineages in the thymus
PNAS 2004 101: 9339-9344; published online before print June 9 2004, 10.1073/pnas.0402654101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Catrin M. McGregor, Stephen P. Schoenberger, and E. Allison Green

CD154 is a negative regulator of autoaggressive CD8⁺ T cells in type 1 diabetes
PNAS 2004 101: 9345-9350; published online before print June 10 2004, 10.1073/pnas.0402807101 [Abstract] [Full Text] [PDF]  

James P. O'Keefe, Kelly Blaine, Maria-Luisa Alegre, and Thomas F. Gajewski

Formation of a central supramolecular activation cluster is not required for activation of naive CD8⁺ T cells
PNAS 2004 101: 9351-9356; published online before print June 10 2004, 10.1073/pnas.0305965101 [Abstract] [Full Text] [PDF]  

Derek C. Lenz, Sabine K. Kurz, Edward Lemmens, Stephen P. Schoenberger, Jonathan Sprent, Michael B. A. Oldstone, and Dirk Homann

IL-7 regulates basal homeostatic proliferation of antiviral CD4⁺T cell memory
PNAS 2004 101: 9357-9362; published online before print June 14 2004, 10.1073/pnas.0400640101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Qiyuan Chen, Heather Jackson, Phillip Parente, Tina Luke, Mark Rizkalla, Tsin Yee Tai, He-Cheng Zhu, Nicole A. Mifsud, Nektaria Dimopoulos, Kelly-Anne Masterman, Wendie Hopkins, Heather Goldie, Eugene Maraskovsky, Simon Green, Lena Miloradovic, James McCluskey, Lloyd J. Old, Ian D. Davis, Jonathan Cebon, and Weisan Chen

Immunodominant CD4⁺ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant
PNAS 2004 101: 9363-9368; published online before print June 14 2004, 10.1073/pnas.0403271101 [Abstract] [Full Text] [PDF]  

Xiaodi Hu, Yoshimasa Yagi, Takahiro Tanji, Sili Zhou, and Y. Tony Ip

Multimerization and interaction of Toll and Spätzle in Drosophila
PNAS 2004 101: 9369-9374; published online before print June 14 2004, 10.1073/pnas.0307062101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Otabek Imamov, Andrea Morani, Gil-Jin Shim, Yoko Omoto, Christina Thulin-Andersson, Margaret Warner, and Jan-Åke Gustafsson

Estrogen receptor regulates epithelial cellular differentiation in the mouse ventral prostate
PNAS 2004 101: 9375-9380; published online before print June 8 2004, 10.1073/pnas.0403041101 [Abstract] [Full Text] [PDF]  

Pirjo Laakkonen, Maria E. Åkerman, Hector Biliran, Meng Yang, Fernando Ferrer, Terhi Karpanen, Robert M. Hoffman, and Erkki Ruoslahti

Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells
PNAS 2004 101: 9381-9386; published online before print June 14 2004, 10.1073/pnas.0403317101 [Abstract] [Full Text] [PDF]  

Paul Rosenberg, April Hawkins, Jonathan Stiber, John M. Shelton, Kelley Hutcheson, Rhonda Bassel-Duby, Dong Min Shin, Zhen Yan, and R. Sanders Williams

TRPC3 channels confer cellular memory of recent neuromuscular activity
PNAS 2004 101: 9387-9392; published online before print June 15 2004, 10.1073/pnas.0308179101 [Abstract] [Full Text] [PDF]  

Songdong Meng, Debasish Tripathy, Sanjay Shete, Raheela Ashfaq, Barbara Haley, Steve Perkins, Peter Beitsch, Amanullah Khan, David Euhus, Cynthia Osborne, Eugene Frenkel, Susan Hoover, Marilyn Leitch, Edward Clifford, Ellen Vitetta, Larry Morrison, Dorothee Herlyn, Leon W. M. M. Terstappen, Timothy Fleming, Tanja Fehm, Thomas Tucker, Nancy Lane, Jianqiang Wang, and Jonathan Uhr

HER-2 gene amplification can be acquired as breast cancer progresses
PNAS 2004 101: 9393-9398; published online before print June 11 2004, 10.1073/pnas.0402993101 [Abstract] [Full Text] [PDF]  

Hittu Matta and Preet M. Chaudhary

Activation of alternative NF-B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1-converting enzyme inhibitory protein (vFLIP)
PNAS 2004 101: 9399-9404; published online before print June 9 2004, 10.1073/pnas.0308016101 [Abstract] [Full Text] [PDF]  

Microbiology

Martin L. Koser, James P. McGettigan, Gene S. Tan, Mary Ellen Smith, Hilary Koprowski, Bernhard Dietzschold, and Matthias J. Schnell

Rabies virus nucleoprotein as a carrier for foreign antigens
PNAS 2004 101: 9405-9410; published online before print June 14 2004, 10.1073/pnas.0403060101 [Abstract] [Full Text] [PDF]  

Luca Benetti and Bernard Roizman

Herpes simplex virus protein kinase U_S3 activates and functionally overlaps protein kinase A to block apoptosis
PNAS 2004 101: 9411-9416; published online before print June 10 2004, 10.1073/pnas.0403160101 [Abstract] [Full Text] [PDF]  

Martine P. Bos, Boris Tefsen, Jeroen Geurtsen, and Jan Tommassen

Identification of an outer membrane protein required for the transport of lipopolysaccharide to the bacterial cell surface
PNAS 2004 101: 9417-9422; published online before print June 10 2004, 10.1073/pnas.0402340101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mireille Ansaldi, Laurence Théraulaz, and Vincent Méjean

TorI, a response regulator inhibitor of phage origin in Escherichia coli
PNAS 2004 101: 9423-9428; published online before print June 14 2004, 10.1073/pnas.0401927101 [Abstract] [Full Text] [PDF]  

Mei-Ling Li and Victor Stollar

Identification of the amino acid sequence in Sindbis virus nsP4 that binds to the promoter for the synthesis of the subgenomic RNA
PNAS 2004 101: 9429-9434; published online before print June 14 2004, 10.1073/pnas.0400995101 [Abstract] [Full Text] [PDF]  

Neuroscience

Eric J. Benner, R. Lee Mosley, Chris J. Destache, Travis B. Lewis, Vernice Jackson-Lewis, Santhi Gorantla, Craig Nemachek, Steven R. Green, Serge Przedborski, and Howard E. Gendelman

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
PNAS 2004 101: 9435-9440; published online before print June 14 2004, 10.1073/pnas.0400569101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Qi Zhang, Mitsunori Fukuda, Elisabeth Van Bockstaele, Olivier Pascual, and Philip G. Haydon

Synaptotagmin IV regulates glial glutamate release
PNAS 2004 101: 9441-9446; published online before print June 14 2004, 10.1073/pnas.0401960101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Alex Proekt, Vladimir Brezina, and Klaudiusz R. Weiss

Dynamical basis of intentions and expectations in a simple neuronal network
PNAS 2004 101: 9447-9452; published online before print June 14 2004, 10.1073/pnas.0402002101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Dong Ya Zhu, Lorraine Lau, Shu Hong Liu, Jian She Wei, and You Ming Lu

Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus
PNAS 2004 101: 9453-9457; published online before print June 14 2004, 10.1073/pnas.0401063101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Yue Wang, Sic L. Chan, Lucio Miele, Pamela J. Yao, Jennifer Mackes, Donald K. Ingram, Mark P. Mattson, and Katsutoshi Furukawa

Involvement of Notch signaling in hippocampal synaptic plasticity
PNAS 2004 101: 9458-9462; published online before print June 9 2004, 10.1073/pnas.0308126101 [Abstract] [Full Text] [PDF]  

Pharmacology

Andrew D. Levin, Neda Vukmirovic, Chao-Wei Hwang, and Elazer R. Edelman

Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel
PNAS 2004 101: 9463-9467; published online before print June 14 2004, 10.1073/pnas.0400918101 [Abstract] [Full Text] [PDF]  

Hossein Tezval, Olaf Jahn, Cedomir Todorovic, Astrid Sasse, Klaus Eckart, and Joachim Spiess

Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model
PNAS 2004 101: 9468-9473; published online before print June 10 2004, 10.1073/pnas.0403159101 [Abstract] [Full Text] [PDF]  

Physiology

M. Sausbier, H. Hu, C. Arntz, S. Feil, S. Kamm, H. Adelsberger, U. Sausbier, C. A. Sailer, R. Feil, F. Hofmann, M. Korth, M. J. Shipston, H.-G. Knaus, D. P. Wolfer, C. M. Pedroarena, J. F. Storm, and P. Ruth

Cerebellar ataxia and Purkinje cell dysfunction caused by Ca²⁺-activated K⁺ channel deficiency
PNAS 2004 101: 9474-9478; published online before print June 11 2004, 10.1073/pnas.0401702101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Peter J. Hanley, Boris Musset, Vijay Renigunta, Sven H. Limberg, Alexander H. Dalpke, Rainer Sus, Klaus M. Heeg, Regina Preisig-Müller, and Jürgen Daut

Extracellular ATP induces oscillations of intracellular Ca²⁺ and membrane potential and promotes transcription of IL-6 in macrophages
PNAS 2004 101: 9479-9484; published online before print June 11 2004, 10.1073/pnas.0400733101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Huiren Zhao, Harn Shiue, Sara Palkon, Yingmin Wang, Patrick Cullinan, Janis K. Burkhardt, Mark W. Musch, Eugene B. Chang, and Jerrold R. Turner

Ezrin regulates NHE3 translocation and activation after Na⁺-glucose cotransport
PNAS 2004 101: 9485-9490; published online before print June 14 2004, 10.1073/pnas.0308400101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Zheng Zhang, Natalia I. Dmitrieva, Jong-Hwan Park, Rodney L. Levine, and Maurice B. Burg From The Cover: High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA PNAS 2004 101: 9491-9496; published online before print June 9 2004, 10.1073/pnas.0402961101 [Abstract] [Full Text] [PDF]   See Commentary on page 9177

Plant Biology

Jan Zouhar, Glenn R. Hicks, and Natasha V. Raikhel

Sorting inhibitors (Sortins): Chemical compounds to study vacuolar sorting in Arabidopsis
PNAS 2004 101: 9497-9501; published online before print June 9 2004, 10.1073/pnas.0402121101 [Abstract] [Full Text] [PDF]  

Morten Schiøtt, Shawn M. Romanowsky, Lone Bækgaard, Mia Kyed Jakobsen, Michael G. Palmgren, and Jeffrey F. Harper

A plant plasma membrane Ca²⁺ pump is required for normal pollen tube growth and fertilization
PNAS 2004 101: 9502-9507; published online before print June 14 2004, 10.1073/pnas.0401542101 [Abstract] [Full Text] [PDF]  

Wenhua Zhang, Chunbo Qin, Jian Zhao, and Xuemin Wang

Phospholipase D1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling
PNAS 2004 101: 9508-9513; published online before print June 14 2004, 10.1073/pnas.0402112101 [Abstract] [Full Text] [PDF] [Supporting Figure]