Find articles in this issue containing these words:

FROM THE ACADEMY

Bruce Alberts and Harvey V. Fineberg

Editorial: Harnessing new science is vital for biodefense and global health
PNAS 2004 101: 11177; published online before print July 12 2004, 10.1073/pnas.0404433101 [Extract] [Full Text] [PDF]  

Stephen C. Harrison, Bruce Alberts, Ellie Ehrenfeld, Lynn Enquist, Harvey Fineberg, Steven L. McKnight, Bernard Moss, Michael O'Donnell, Hidde Ploegh, Sandra L. Schmid, K. Peter Walter, and Julie Theriot

Perspective: Discovery of antivirals against smallpox
PNAS 2004 101: 11178-11192; published online before print July 12 2004, 10.1073/pnas.0403600101 [Extract] [Full Text] [PDF]  

COMMENTARIES

David Nutt and Anne Lingford-Hughes

Infecting the brain to stop addiction?
PNAS 2004 101: 11193-11194; published online before print July 26 2004, 10.1073/pnas.0404338101 [Extract] [Full Text] [PDF]  

John M. Logsdon, Jr.

Worm genomes hold the smoking guns of intron gain
PNAS 2004 101: 11195-11196; published online before print July 26 2004, 10.1073/pnas.0404148101 [Extract] [Full Text] [PDF]  
See companion article on page 11362

PHYSICAL SCIENCES

Chemistry

SOCIAL SCIENCES

Economic Sciences

Michael W. Binford, Tae Jeong Lee, and Robert M. Townsend

Sampling design for an integrated socioeconomic and ecological survey by using satellite remote sensing and ordination
PNAS 2004 101: 11517-11522; published online before print July 14 2004, 10.1073/pnas.0402593101 [Abstract] [Full Text] [PDF]  

Daniel L. McFadden and Vasu Sunkara

The educative impact of health care treatment on malarial prevention behavior for the poor in Guinea, West Africa
PNAS 2004 101: 11523-11525; published online before print July 26 2004, 10.1073/pnas.0400462101 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Xiaojun Yu, Edward A. Botchwey, Elliot M. Levine, Solomon R. Pollack, and Cato T. Laurencin

Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization
PNAS 2004 101: 11203-11208; published online before print July 26 2004, 10.1073/pnas.0402532101 [Abstract] [Full Text] [PDF]  

Biochemistry

Yueh-Chiang Hu, Peng-Hui Wang, Shuyuan Yeh, Ruey-Sheng Wang, Chao Xie, Qingquan Xu, Xinchang Zhou, Hsiang-Tai Chao, Meng-Yin Tsai, and Chawnshang Chang

Subfertility and defective folliculogenesis in female mice lacking androgen receptor
PNAS 2004 101: 11209-11214; published online before print July 26 2004, 10.1073/pnas.0404372101 [Abstract] [Full Text] [PDF]  

Kazuo Kurihara, Ichiro Tanaka, Toshiyuki Chatake, Michael W. W. Adams, Francis E. Jenney, Jr., Natalia Moiseeva, Robert Bau, and Nobuo Niimura

Neutron crystallographic study on rubredoxin from Pyrococcus furiosus by BIX-3, a single-crystal diffractometer for biomacromolecules
PNAS 2004 101: 11215-11220; published online before print July 22 2004, 10.1073/pnas.0403807101 [Abstract] [Full Text] [PDF]  

Mirko G. Theis, Alexander Knorre, Bettina Kellersch, Jörg Moelleken, Felix Wieland, Waldemar Kolanus, and Michael Famulok

Discriminatory aptamer reveals serum response element transcription regulated by cytohesin-2
PNAS 2004 101: 11221-11226; published online before print July 26 2004, 10.1073/pnas.0402901101 [Abstract] [Full Text] [PDF]  

Hiroki R. Ueda, Wenbin Chen, Yoichi Minami, Sato Honma, Kenichi Honma, Masamitsu Iino, and Seiichi Hashimoto Molecular-timetable methods for detection of body time and rhythm disorders from single-time-point genome-wide expression profiles PNAS 2004 101: 11227-11232; published online before print July 23 2004, 10.1073/pnas.0401882101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Daria J. Hazuda, Neville J. Anthony, Robert P. Gomez, Samson M. Jolly, John S. Wai, Linghang Zhuang, Thorsten E. Fisher, Mark Embrey, James P. Guare, Jr., Melissa S. Egbertson, Joseph P. Vacca, Joel R. Huff, Peter J. Felock, Marc V. Witmer, Kara A. Stillmock, Robert Danovich, Jay Grobler, Michael D. Miller, Amy S. Espeseth, Lixia Jin, I-Wu Chen, Jiunn H. Lin, Kelem Kassahun, Joan D. Ellis, Bradley K. Wong, Wei Xu, Paul G. Pearson, William A. Schleif, Riccardo Cortese, Emilio Emini, Vincenzo Summa, M. Katharine Holloway, and Steven D. Young From the Cover: A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase PNAS 2004 101: 11233-11238; published online before print July 26 2004, 10.1073/pnas.0402357101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Christoph von Ballmoos, Josef Brunner, and Peter Dimroth

The ion channel of F-ATP synthase is the target of toxic organotin compounds
PNAS 2004 101: 11239-11244; published online before print July 26 2004, 10.1073/pnas.0402869101 [Abstract] [Full Text] [PDF]  

Guoxun Chen, Guosheng Liang, Jiafu Ou, Joseph L. Goldstein, and Michael S. Brown

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
PNAS 2004 101: 11245-11250; published online before print July 20 2004, 10.1073/pnas.0404297101 [Abstract] [Full Text] [PDF]  

Benno Wullschleger, Lucia Kuhn-Nentwig, Jan Tromp, Urs Kämpfer, Johann Schaller, Stefan Schürch, and Wolfgang Nentwig

CSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae)
PNAS 2004 101: 11251-11256; published online before print July 22 2004, 10.1073/pnas.0402226101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hitomi Nishio and Martin J. Walsh

CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription
PNAS 2004 101: 11257-11262; published online before print July 21 2004, 10.1073/pnas.0401343101 [Abstract] [Full Text] [PDF]  

Michael Schwartz, Jianbo Chen, Wai-Ming Lee, Michael Janda, and Paul Ahlquist

Alternate, virus-induced membrane rearrangements support positive-strand RNA virus genome replication
PNAS 2004 101: 11263-11268; published online before print July 27 2004, 10.1073/pnas.0404157101 [Abstract] [Full Text] [PDF]  

Krishna M. Vattem and Ronald C. Wek

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
PNAS 2004 101: 11269-11274; published online before print July 26 2004, 10.1073/pnas.0400541101 [Abstract] [Full Text] [PDF]  

Gennady Zolotnitsky, Uri Cogan, Noam Adir, Vered Solomon, Gil Shoham, and Yuval Shoham

Mapping glycoside hydrolase substrate subsites by isothermal titration calorimetry
PNAS 2004 101: 11275-11280; published online before print July 26 2004, 10.1073/pnas.0404311101 [Abstract] [Full Text] [PDF]  

Biophysics

Evan Evans, Andrew Leung, Volkmar Heinrich, and Cheng Zhu

Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond
PNAS 2004 101: 11281-11286; published online before print July 26 2004, 10.1073/pnas.0401870101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Deepa Rajamani, Spencer Thiel, Sandor Vajda, and Carlos J. Camacho

Anchor residues in protein–protein interactions
PNAS 2004 101: 11287-11292; published online before print July 21 2004, 10.1073/pnas.0401942101 [Abstract] [Full Text] [PDF]  

Simon Scheuring, James N. Sturgis, Valerie Prima, Alain Bernadac, Daniel Lévy, and Jean-Louis Rigaud

Watching the photosynthetic apparatus in native membranes
PNAS 2004 101: 11293-11297; published online before print July 23 2004, 10.1073/pnas.0404350101 [Abstract] [Full Text] [PDF]  

Xiaohui Qu, David Wu, Laurens Mets, and Norbert F. Scherer

Nanometer-localized multiple single-molecule fluorescence microscopy
PNAS 2004 101: 11298-11303; published online before print July 26 2004, 10.1073/pnas.0402155101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Oren M. Becker, Yael Marantz, Sharon Shacham, Boaz Inbal, Alexander Heifetz, Ori Kalid, Shay Bar-Haim, Dora Warshaviak, Merav Fichman, and Silvia Noiman G protein-coupled receptors: In silico drug discovery in 3D PNAS 2004 101: 11304-11309; published online before print July 26 2004, 10.1073/pnas.0401862101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Ido Golding and Edward C. Cox

RNA dynamics in live Escherichia coli cells
PNAS 2004 101: 11310-11315; published online before print July 26 2004, 10.1073/pnas.0404443101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Maarten F. M. Engel, Antonie J. W. G. Visser, and Carlo P. M. van Mierlo

Conformation and orientation of a protein folding intermediate trapped by adsorption
PNAS 2004 101: 11316-11321; published online before print July 19 2004, 10.1073/pnas.0401603101 [Abstract] [Full Text] [PDF]  

Cell Biology

Andreas C. W. Jenke, Isa M. Stehle, Frank Herrmann, Tobias Eisenberger, Armin Baiker, Jürgen Bode, Frank O. Fackelmayer, and Hans J. Lipps

Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome
PNAS 2004 101: 11322-11327; published online before print July 22 2004, 10.1073/pnas.0401355101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jaejoon Won, Seungwoo Chang, Sangtaek Oh, and Tae Kook Kim

Small-molecule-based identification of dynamic assembly of E2F–pocket protein–histone deacetylase complex for telomerase regulation in human cells
PNAS 2004 101: 11328-11333; published online before print July 19 2004, 10.1073/pnas.0401801101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Fredrik K. Johansson, Josefin Brodd, Charlotta Eklöf, Maria Ferletta, Göran Hesselager, Carl-Fredrik Tiger, Lene Uhrbom, and Bengt Westermark

Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging
PNAS 2004 101: 11334-11337; published online before print July 23 2004, 10.1073/pnas.0402716101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Evolution

Mayako Kutsukake, Harunobu Shibao, Naruo Nikoh, Mizue Morioka, Tomohiro Tamura, Tamotsu Hoshino, Satoru Ohgiya, and Takema Fukatsu

Venomous protease of aphid soldier for colony defense
PNAS 2004 101: 11338-11343; published online before print July 26 2004, 10.1073/pnas.0402462101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Aaron C. Brault, Ann M. Powers, Diana Ortiz, Jose G. Estrada-Franco, Roberto Navarro-Lopez, and Scott C. Weaver

Venezuelan equine encephalitis emergence: Enhanced vector infection from a single amino acid substitution in the envelope glycoprotein
PNAS 2004 101: 11344-11349; published online before print July 26 2004, 10.1073/pnas.0402905101 [Abstract] [Full Text] [PDF]  

Gro V. Amdam, Kari Norberg, M. Kim Fondrk, and Robert E. Page, Jr.

Reproductive ground plan may mediate colony-level selection effects on individual foraging behavior in honey bees
PNAS 2004 101: 11350-11355; published online before print July 26 2004, 10.1073/pnas.0403073101 [Abstract] [Full Text] [PDF]  

Kazuhiko Kawasaki, Tohru Suzuki, and Kenneth M. Weiss

Genetic basis for the evolution of vertebrate mineralized tissue
PNAS 2004 101: 11356-11361; published online before print July 22 2004, 10.1073/pnas.0404279101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Avril Coghlan and Kenneth H. Wolfe From the Cover: Origins of recently gained introns in Caenorhabditis PNAS 2004 101: 11362-11367; published online before print July 8 2004, 10.1073/pnas.0308192101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE   See Commentary on page 11195

Genetics

Nicolas Vogt, Sandrine-Hélène Lefèvre, Françoise Apiou, Anne-Marie Dutrillaux, Andrej Cör, Pascal Leuraud, Marie-France Poupon, Bernard Dutrillaux, Michelle Debatisse, and Bernard Malfoy

Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas
PNAS 2004 101: 11368-11373; published online before print July 21 2004, 10.1073/pnas.0402979101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kaustuv Sanyal, Mary Baum, and John Carbon

Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique
PNAS 2004 101: 11374-11379; published online before print July 22 2004, 10.1073/pnas.0404318101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kentaro Yamashita, Miki Shinohara, and Akira Shinohara

Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis
PNAS 2004 101: 11380-11385; published online before print July 27 2004, 10.1073/pnas.0400078101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Carl S. Goodyear and Gregg J. Silverman

Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes
PNAS 2004 101: 11392-11397; published online before print July 23 2004, 10.1073/pnas.0404382101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Kate E. Lawlor, Ian K. Campbell, Donald Metcalf, Kristy O'Donnell, Annemarie van Nieuwenhuijze, Andrew W. Roberts, and Ian P. Wicks

Critical role for granulocyte colony-stimulating factor in inflammatory arthritis
PNAS 2004 101: 11398-11403; published online before print July 22 2004, 10.1073/pnas.0404328101 [Abstract] [Full Text] [PDF]  

Nobuhiro Yuki, Keiichiro Susuki, Michiaki Koga, Yukihiro Nishimoto, Masaaki Odaka, Koichi Hirata, Kyoji Taguchi, Tadashi Miyatake, Koichi Furukawa, Tetsuji Kobata, and Mitsunori Yamada

Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain–Barré syndrome
PNAS 2004 101: 11404-11409; published online before print July 26 2004, 10.1073/pnas.0402391101 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Aurélie Baguet and Mark Bix

Chromatin landscape dynamics of the Il4–Il13 locus during T helper 1 and 2 development
PNAS 2004 101: 11410-11415; published online before print July 22 2004, 10.1073/pnas.0403334101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hubertus Hochrein, Beatrix Schlatter, Meredith O'Keeffe, Cornelia Wagner, Frank Schmitz, Matthias Schiemann, Stefan Bauer, Mark Suter, and Hermann Wagner

Herpes simplex virus type-1 induces IFN- production via Toll-like receptor 9-dependent and -independent pathways
PNAS 2004 101: 11416-11421; published online before print July 22 2004, 10.1073/pnas.0403555101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Ali Sadra, Tomas Cinek, and John B. Imboden

Translocation of CD28 to lipid rafts and costimulation of IL-2
PNAS 2004 101: 11422-11427; published online before print July 27 2004, 10.1073/pnas.0403792101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Donald C. Malins, Naomi K. Gilman, Virginia M. Green, Thomas M. Wheeler, Edward A. Barker, Mark A. Vinson, Mohammad Sayeeduddin, Karl Erik Hellström, and Katie M. Anderson

Metastatic cancer DNA phenotype identified in normal tissues surrounding metastasizing prostate carcinomas
PNAS 2004 101: 11428-11431; published online before print July 27 2004, 10.1073/pnas.0404572101 [Abstract] [Full Text] [PDF]  

Emely Castro-Rivera, Sophia Ran, Philip Thorpe, and John D. Minna

Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF₁₆₅ antagonizes this effect
PNAS 2004 101: 11432-11437; published online before print July 23 2004, 10.1073/pnas.0403969101 [Abstract] [Full Text] [PDF]  

Craig K. Abbey, Alexander D. Borowsky, Erik T. McGoldrick, Jeffrey P. Gregg, Jeannie E. Maglione, Robert D. Cardiff, and Simon R. Cherry

In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia
PNAS 2004 101: 11438-11443; published online before print July 26 2004, 10.1073/pnas.0404396101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Alison R. Moliterno, Donna M. Williams, Laura I. Gutierrez-Alamillo, Roberto Salvatori, Roxann G. Ingersoll, and Jerry L. Spivak

Mpl Baltimore: A thrombopoietin receptor polymorphism associated with thrombocytosis
PNAS 2004 101: 11444-11447; published online before print July 21 2004, 10.1073/pnas.0404241101 [Abstract] [Full Text] [PDF]  

Microbiology

Neuroscience

B. A. Strange and R. J. Dolan

-Adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses
PNAS 2004 101: 11454-11458; published online before print July 21 2004, 10.1073/pnas.0404282101 [Abstract] [Full Text] [PDF]  

Martine Maïbèche-Coisne, Alexander A. Nikonov, Yuko Ishida, Emmanuelle Jacquin-Joly, and Walter S. Leal Pheromone anosmia in a scarab beetle induced by in vivo inhibition of a pheromone-degrading enzyme PNAS 2004 101: 11459-11464; published online before print July 26 2004, 10.1073/pnas.0403537101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Minoru Kobayashi, Ciro Iaccarino, Adolfo Saiardi, Valérie Heidt, Yuri Bozzi, Roberto Picetti, Carmine Vitale, Heiner Westphal, John Drago, and Emiliana Borrelli

Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice
PNAS 2004 101: 11465-11470; published online before print July 22 2004, 10.1073/pnas.0402028101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Pharmacology

Ling Tao, Erhe Gao, Nathan S. Bryan, Yan Qu, Hui-Rong Liu, Aihua Hu, Theodore A. Christopher, Bernard L. Lopez, Junji Yodoi, Walter J. Koch, Martin Feelisch, and Xin L. Ma

Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: Role of S-nitrosation
PNAS 2004 101: 11471-11476; published online before print July 26 2004, 10.1073/pnas.0402941101 [Abstract] [Full Text] [PDF]  

Physiology

Xunde Wang, Jose E. Tanus-Santos, Christopher D. Reiter, Andre Dejam, Sruti Shiva, Reginald D. Smith, Neil Hogg, and Mark T. Gladwin

Biological activity of nitric oxide in the plasmatic compartment
PNAS 2004 101: 11477-11482; published online before print July 16 2004, 10.1073/pnas.0402201101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kenji Matsushita, Craig N. Morrell, and Charles J. Lowenstein

Sphingosine 1-phosphate activates Weibel-Palade body exocytosis
PNAS 2004 101: 11483-11487; published online before print July 23 2004, 10.1073/pnas.0400185101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Zhuangjie Li, Wei Huang, Zong Lai Jiang, Hans Gregersen, and Yuan-Cheng Fung

Tissue remodeling of rat pulmonary arteries in recovery from hypoxic hypertension
PNAS 2004 101: 11488-11493; published online before print July 26 2004, 10.1073/pnas.0404084101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Plant Biology

Vaniyambadi V. Sridhar, Anandkumar Surendrarao, Deyarina Gonzalez, R. Steven Conlan, and Zhongchi Liu

Transcriptional repression of target genes by LEUNIG and SEUSS, two interacting regulatory proteins for Arabidopsis flower development
PNAS 2004 101: 11494-11499; published online before print July 26 2004, 10.1073/pnas.0403055101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Robert A. Sharrock and Ted Clack

Heterodimerization of type II phytochromes in Arabidopsis
PNAS 2004 101: 11500-11505; published online before print July 23 2004, 10.1073/pnas.0404286101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Shimon Rachmilevitch, Asaph B. Cousins, and Arnold J. Bloom

Nitrate assimilation in plant shoots depends on photorespiration
PNAS 2004 101: 11506-11510; published online before print July 22 2004, 10.1073/pnas.0404388101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Eric Bonnet, Jan Wuyts, Pierre Rouzé, and Yves Van de Peer

Detection of 91 potential conserved plant microRNAs in Arabidopsis thaliana and Oryza sativa identifies important target genes
PNAS 2004 101: 11511-11516; published online before print July 22 2004, 10.1073/pnas.0404025101 [Abstract] [Full Text] [PDF] [Supporting Information]  

CORRECTIONS

Correction for Bard et al., Epitope and isotype specificities of antibodies to -amyloid peptide for protection against Alzheimer's disease-like neuropathology, PNAS 2003 100:2023-2028 [Extract] [Full Text] [PDF]