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EDITORIAL

K. C. Nicolaou

Natural Product Synthesis Special Feature: The art and science of constructing the molecules of nature
PNAS 2004 101: 11928. [Extract] [Full Text] [PDF]  

COMMENTARIES

Richard J. Davidson, Jeffrey S. Maxwell, and Alexander J. Shackman

The privileged status of emotion in the brain
PNAS 2004 101: 11915-11916; published online before print August 10 2004, 10.1073/pnas.0404264101 [Extract] [Full Text] [PDF]  

PERSPECTIVES

K. C. Nicolaou and Scott A. Snyder

From The Cover, Natural Product Synthesis Special Feature: The essence of total synthesis
PNAS 2004 101: 11929-11936; published online before print August 9 2004, 10.1073/pnas.0403799101 [Abstract] [Full Text] [PDF]  

Stacy J. Keding and Samuel J. Danishefsky

Natural Product Synthesis Special Feature: Prospects for total synthesis: A vision for a totally synthetic vaccine targeting epithelial tumors
PNAS 2004 101: 11937-11942; published online before print July 27 2004, 10.1073/pnas.0401894101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Emily A. Peterson and Larry E. Overman

Natural Product Synthesis Special Feature: Contiguous stereogenic quaternary carbons: A daunting challenge in natural products synthesis
PNAS 2004 101: 11943-11948; published online before print July 1 2004, 10.1073/pnas.0402416101 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

André A. Moreira, Abhishek Mathur, Daniel Diermeier, and Luís A. N. Amaral

Efficient system-wide coordination in noisy environments
PNAS 2004 101: 12085-12090; published online before print August 5 2004, 10.1073/pnas.0400672101 [Abstract] [Full Text] [PDF]  

Applied Physical Sciences

F. Remacle and R. D. Levine

Quasiclassical computation
PNAS 2004 101: 12091-12095; published online before print August 5 2004, 10.1073/pnas.0403871101 [Abstract] [Full Text] [PDF]  

Chemistry

Brian K. Albrecht and Robert M. Williams

Natural Product Synthesis Special Feature: A concise, total synthesis of the TMC-95A/B proteasome inhibitors
PNAS 2004 101: 11949-11954; published online before print May 26 2004, 10.1073/pnas.0308432101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Dustin J. Mergott, Scott A. Frank, and William R. Roush

Natural Product Synthesis Special Feature: Total synthesis of (–)-spinosyn A
PNAS 2004 101: 11955-11959; published online before print June 1 2004, 10.1073/pnas.0401247101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Bodo Scheiper, Frank Glorius, Andreas Leitner, and Alois Fürstner

Natural Product Synthesis Special Feature: Catalysis-based enantioselective total synthesis of the macrocyclic spermidine alkaloid isooncinotine
PNAS 2004 101: 11960-11965; published online before print May 12 2004, 10.1073/pnas.0401322101 [Abstract] [Full Text] [PDF]  

Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama

Natural Product Synthesis Special Feature: Stereocontrolled total synthesis of (+)-vincristine
PNAS 2004 101: 11966-11970; published online before print May 12 2004, 10.1073/pnas.0401323101 [Abstract] [Full Text] [PDF]  

David J. Richard, Bruno Schiavi, and Madeleine M. Joullié

Natural Product Synthesis Special Feature: Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle
PNAS 2004 101: 11971-11976; published online before print May 12 2004, 10.1073/pnas.0401407101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Dongwoo Shin, Yosup Rew, and Dale L. Boger

Natural Product Synthesis Special Feature: Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complex
PNAS 2004 101: 11977-11979; published online before print June 2 2004, 10.1073/pnas.0401419101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Johann Mulzer, Stefan Pichlmair, Martin P. Green, Maria M. B. Marques, and Harry J. Martin

Natural Product Synthesis Special Feature: Toward the synthesis of the carbacylic ansa antibiotic kendomycin
PNAS 2004 101: 11980-11985; published online before print July 26 2004, 10.1073/pnas.0401503101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, and Jonathan Stafford

Natural Product Synthesis Special Feature: Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C₅–C₁₆ degradation fragment of reidispongiolide A
PNAS 2004 101: 11986-11991; published online before print June 16 2004, 10.1073/pnas.0401548101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Isao Kadota, Yueqing Hu, Garrick K. Packard, and Scott D. Rychnovsky

Natural Product Synthesis Special Feature: A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols
PNAS 2004 101: 11992-11995; published online before print June 10 2004, 10.1073/pnas.0401552101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Stephen Hanessian, Vincent Mascitti, and Simon Giroux

Natural Product Synthesis Special Feature: Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: The "ester" effect in acyclic 1,3-induction of deoxypropionates
PNAS 2004 101: 11996-12001; published online before print June 21 2004, 10.1073/pnas.0401637101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Ken Ohmori, Naoko Ushimaru, and Keisuke Suzuki

Natural Product Synthesis Special Feature: Oligomeric catechins: An enabling synthetic strategy by orthogonal activation and C(8) protection
PNAS 2004 101: 12002-12007; published online before print May 12 2004, 10.1073/pnas.0401651101 [Abstract] [Full Text] [PDF]  

Sivaraman Dandapani, Mario Jeske, and Dennis P. Curran

Natural Product Synthesis Special Feature: Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach
PNAS 2004 101: 12008-12012; published online before print May 24 2004, 10.1073/pnas.0401677101 [Abstract] [Full Text] [PDF]  

Masayuki Inoue, Keisuke Miyazaki, Hisatoshi Uehara, Megumi Maruyama, and Masahiro Hirama

Natural Product Synthesis Special Feature: First- and second-generation total synthesis of ciguatoxin CTX3C
PNAS 2004 101: 12013-12018; published online before print June 15 2004, 10.1073/pnas.0401684101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Aubry K. Miller, Daniel H. Byun, Christopher M. Beaudry, and Dirk Trauner

Natural Product Synthesis Special Feature: The total synthesis of (–)-crispatene
PNAS 2004 101: 12019-12023; published online before print July 23 2004, 10.1073/pnas.0401787101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Gerald Pattenden, Miguel A. Gonzalez, Stuart McCulloch, Affo Walter, and Steven J. Woodhead

Natural Product Synthesis Special Feature: A total synthesis of estrone based on a novel cascade of radical cyclizations
PNAS 2004 101: 12024-12029; published online before print August 10 2004, 10.1073/pnas.0401925101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Eric J. Tisdale, Irina Slobodov, and Emmanuel A. Theodorakis

Natural Product Synthesis Special Feature: Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels–Alder/Claisen rearrangement
PNAS 2004 101: 12030-12035; published online before print June 21 2004, 10.1073/pnas.0401932101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Carl A. Morales, Mark E. Layton, and Matthew D. Shair

Natural Product Synthesis Special Feature: Synthesis of (-)-longithorone A: Using organic synthesis to probe a proposed biosynthesis
PNAS 2004 101: 12036-12041; published online before print June 9 2004, 10.1073/pnas.0401952101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Amos B. Smith, III, Christopher M. Adams, Stephanie A. Lodise Barbosa, and Andrew P. Degnan

Natural Product Synthesis Special Feature: A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide
PNAS 2004 101: 12042-12047; published online before print May 26 2004, 10.1073/pnas.0402084101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Andrew M. Haidle and Andrew G. Myers

Natural Product Synthesis Special Feature: An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and cytochalasin B
PNAS 2004 101: 12048-12053; published online before print June 18 2004, 10.1073/pnas.0402111101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Peter Korakas, Stuart Chaffee, J. Brad Shotwell, Pamela Duque, and John L. Wood

Natural Product Synthesis Special Feature: Efficient construction of the securine A carbon skeleton
PNAS 2004 101: 12054-12057; published online before print July 27 2004, 10.1073/pnas.0402274101 [Abstract] [Full Text] [PDF] [Supporting Information]  

David R. Williams, Andre A. Kiryanov, Ulrich Emde, Michael P. Clark, Martin A. Berliner, and Jonathan T. Reeves

Natural Product Synthesis Special Feature: Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A
PNAS 2004 101: 12058-12063; published online before print July 26 2004, 10.1073/pnas.0402477101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lucy M. Stark, Klaus Pekari, and Erik J. Sorensen

Natural Product Synthesis Special Feature: A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone
PNAS 2004 101: 12064-12066; published online before print July 1 2004, 10.1073/pnas.0402563101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jiehao Chen and Craig J. Forsyth

Natural Product Synthesis Special Feature: Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A
PNAS 2004 101: 12067-12072; published online before print July 1 2004, 10.1073/pnas.0402752101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Steven V. Ley, Alessandra Antonello, Emily P. Balskus, David T. Booth, Søren B. Christensen, Ed Cleator, Helen Gold, Klemens Högenauer, Udo Hünger, Rebecca M. Myers, Steven F. Oliver, Oliver Simic, Martin D. Smith, Helmer Søhoel, and Alison J. A. Woolford

Natural Product Synthesis Special Feature: Synthesis of the thapsigargins
PNAS 2004 101: 12073-12078; published online before print June 28 2004, 10.1073/pnas.0403300101 [Abstract] [Full Text] [PDF]  

Hamish S. Christie and Clayton H. Heathcock

Natural Product Synthesis Special Feature: Total synthesis of (±)-halichlorine, (±)-pinnaic acid, and (±)-tauropinnaic acid
PNAS 2004 101: 12079-12084; published online before print August 6 2004, 10.1073/pnas.0403887101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Alexandra Navrotsky

Energetic clues to pathways to biomineralization: Precursors, clusters, and nanoparticles
PNAS 2004 101: 12096-12101; published online before print August 5 2004, 10.1073/pnas.0404778101 [Abstract] [Full Text] [PDF]  

Computer Sciences

Physics

Arthur Ashkin

Design for an optical cw atom laser
PNAS 2004 101: 12108-12113; published online before print August 9 2004, 10.1073/pnas.0404435101 [Abstract] [Full Text] [PDF]  

Statistics

Qing Zhou and Wing H. Wong

CisModule: De novo discovery of cis-regulatory modules by hierarchical mixture modeling
PNAS 2004 101: 12114-12119; published online before print August 5 2004, 10.1073/pnas.0402858101 [Abstract] [Full Text] [PDF] [Supporting Information]  

G. J. Gibson, A. Kleczkowski, and C. A. Gilligan

Bayesian analysis of botanical epidemics using stochastic compartmental models
PNAS 2004 101: 12120-12124; published online before print August 9 2004, 10.1073/pnas.0400829101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Social Sciences

Alejandro Portes and Lingxin Hao Inaugural Article by a Recently Elected Academy Member: Inaugural Article: The schooling of children of immigrants: Contextual effects on the educational attainment of the second generation PNAS 2004 101: 11920-11927; published online before print July 2 2004, 10.1073/pnas.0403418101 [Abstract] [Full Text] [PDF] [Supporting Table]

Samuli Helle, Virpi Lummaa, and Jukka Jokela

Accelerated immunosenescence in preindustrial twin mothers
PNAS 2004 101: 12391-12396; published online before print August 4 2004, 10.1073/pnas.0402215101 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Anthropology

R. Bonnefille, R. Potts, F. Chalié, D. Jolly, and O. Peyron

High-resolution vegetation and climate change associated with Pliocene Australopithecus afarensis
PNAS 2004 101: 12125-12129; published online before print August 10 2004, 10.1073/pnas.0401709101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Applied Biological Sciences

Sean A. Beausoleil, Mark Jedrychowski, Daniel Schwartz, Joshua E. Elias, Judit Villén, Jiaxu Li, Martin A. Cohn, Lewis C. Cantley, and Steven P. Gygi

Large-scale characterization of HeLa cell nuclear phosphoproteins
PNAS 2004 101: 12130-12135; published online before print August 9 2004, 10.1073/pnas.0404720101 [Abstract] [Full Text] [PDF] [Supporting Infromation]  

Biochemistry

Greg L. Hersch, Tania A. Baker, and Robert T. Sauer

SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags
PNAS 2004 101: 12136-12141; published online before print August 5 2004, 10.1073/pnas.0404733101 [Abstract] [Full Text] [PDF]  

Chad A. Brautigam, Barbara S. Smith, Zhiquan Ma, Maya Palnitkar, Diana R. Tomchick, Mischa Machius, and Johann Deisenhofer Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana PNAS 2004 101: 12142-12147; published online before print August 6 2004, 10.1073/pnas.0404851101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Lan Guan and H. Ronald Kaback

Binding affinity of lactose permease is not altered by the H⁺ electrochemical gradient
PNAS 2004 101: 12148-12152; published online before print August 10 2004, 10.1073/pnas.0404936101 [Abstract] [Full Text] [PDF]  

Tae Whan Kim, Yong-Jae Kwon, Jung Mo Kim, Young-Hwa Song, Se Nyun Kim, and Young-Joon Kim

MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators
PNAS 2004 101: 12153-12158; published online before print August 5 2004, 10.1073/pnas.0401985101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Noriyo Mitome, Toshiharu Suzuki, Shigehiko Hayashi, and Masasuke Yoshida Thermophilic ATP synthase has a decamer c-ring: Indication of noninteger 10:3 H+/ATP ratio and permissive elastic coupling PNAS 2004 101: 12159-12164; published online before print August 9 2004, 10.1073/pnas.0403545101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Eva Grönroos, Alexei A. Terentiev, Tanel Punga, and Johan Ericsson

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress
PNAS 2004 101: 12165-12170; published online before print August 4 2004, 10.1073/pnas.0402283101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Christine C. McPhillips, Judith W. Hyle, and Daniel Reines

Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo
PNAS 2004 101: 12171-12176; published online before print August 3 2004, 10.1073/pnas.0403341101 [Abstract] [Full Text] [PDF]  

Biophysics

In-Chul Yeh and Gerhard Hummer

Nucleic acid transport through carbon nanotube membranes
PNAS 2004 101: 12177-12182; published online before print August 9 2004, 10.1073/pnas.0402699101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Mayssam H. Ali, Ezra Peisach, Karen N. Allen, and Barbara Imperiali

X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture
PNAS 2004 101: 12183-12188; published online before print August 9 2004, 10.1073/pnas.0401245101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Takashi Ishikawa, Naiqian Cheng, Xiong Liu, Edward D. Korn, and Alasdair C. Steven

Subdomain organization of the Acanthamoeba myosin IC tail from cryo-electron microscopy
PNAS 2004 101: 12189-12194; published online before print August 9 2004, 10.1073/pnas.0404835101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Björn Nadrowski, Pascal Martin, and Frank Jülicher

Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity
PNAS 2004 101: 12195-12200; published online before print August 9 2004, 10.1073/pnas.0403020101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rachel Kolodny and Nathan Linial From The Cover: Approximate protein structural alignment in polynomial time PNAS 2004 101: 12201-12206; published online before print August 10 2004, 10.1073/pnas.0404383101 [Abstract] [Full Text] [PDF] [Supporting Information]

Jan Bieschke, Petra Weber, Nikolaus Sarafoff, Michael Beekes, Armin Giese, and Hans Kretzschmar

Autocatalytic self-propagation of misfolded prion protein
PNAS 2004 101: 12207-12211; published online before print August 5 2004, 10.1073/pnas.0404650101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Cell Biology

Zhi-Jian Su, Christopher N. Hahn, Gregory J. Goodall, Niamh M. Reck, Annabell F. Leske, Ann Davy, Gabriel Kremmidiotis, Mathew A. Vadas, and Jennifer R. Gamble

A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis
PNAS 2004 101: 12212-12217; published online before print August 9 2004, 10.1073/pnas.0404631101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Developmental Biology

Ecology

G. J. Gibson, A. Kleczkowski, and C. A. Gilligan

Bayesian analysis of botanical epidemics using stochastic compartmental models
PNAS 2004 101: 12120-12124; published online before print August 9 2004, 10.1073/pnas.0400829101 [Abstract] [Full Text] [PDF]  

Tamás Székely, Robert P. Freckleton, and John D. Reynolds

Sexual selection explains Rensch's rule of size dimorphism in shorebirds
PNAS 2004 101: 12224-12227; published online before print August 10 2004, 10.1073/pnas.0404503101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Susan J. Murch, Paul Alan Cox, and Sandra Anne Banack A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam PNAS 2004 101: 12228-12231; published online before print August 4 2004, 10.1073/pnas.0404926101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Evolution

Chau-Ti Ting, Shun-Chern Tsaur, Sha Sun, William E. Browne, Yung-Chia Chen, Nipam H. Patel, and Chung-I Wu

Gene duplication and speciation in Drosophila: Evidence from the Odysseus locus
PNAS 2004 101: 12232-12235; published online before print August 10 2004, 10.1073/pnas.0401975101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Osnat Ashur-Fabian, Aaron Avivi, Luba Trakhtenbrot, Konstantin Adamsky, Meytal Cohen, Gadi Kajakaro, Alma Joel, Ninette Amariglio, Eviatar Nevo, and Gideon Rechavi

Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation
PNAS 2004 101: 12236-12241; published online before print August 9 2004, 10.1073/pnas.0404998101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Samuli Helle, Virpi Lummaa, and Jukka Jokela

Accelerated immunosenescence in preindustrial twin mothers
PNAS 2004 101: 12391-12396; published online before print August 4 2004, 10.1073/pnas.0402215101 [Abstract] [Full Text] [PDF]  

Genetics

Qing Zhou and Wing H. Wong

CisModule: De novo discovery of cis-regulatory modules by hierarchical mixture modeling
PNAS 2004 101: 12114-12119; published online before print August 5 2004, 10.1073/pnas.0402858101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Petr Obrdlik, Mohamed El-Bakkoury, Tanja Hamacher, Corinna Cappellaro, Cristina Vilarino, Carola Fleischer, Heinz Ellerbrok, Richard Kamuzinzi, Valérie Ledent, Damien Blaudez, Dale Sanders, Jose L. Revuelta, Eckhard Boles, Bruno André, and Wolf B. Frommer

K⁺ channel interactions detected by a genetic system optimized for systematic studies of membrane protein interactions
PNAS 2004 101: 12242-12247; published online before print August 6 2004, 10.1073/pnas.0404467101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yuuko Ninomiya, Keiichiro Suzuki, Chizu Ishii, and Hirokazu Inoue From The Cover: Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining PNAS 2004 101: 12248-12253; published online before print August 6 2004, 10.1073/pnas.0402780101 [Abstract] [Full Text] [PDF] [Supporting Figure]

Immunology

Stéphane Sidobre, Kirsten J. L. Hammond, Lise Bénazet-Sidobre, Sergei D. Maltsev, Stewart K. Richardson, Rachel M. Ndonye, Amy R. Howell, Teruyuki Sakai, Gurdyal S. Besra, Steven A. Porcelli, and Mitchell Kronenberg

The T cell antigen receptor expressed by V14i NKT cells has a unique mode of glycosphingolipid antigen recognition
PNAS 2004 101: 12254-12259; published online before print August 10 2004, 10.1073/pnas.0404632101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ronald J. Messer, Ulf Dittmer, Karin E. Peterson, and Kim J. Hasenkrug

Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection
PNAS 2004 101: 12260-12265; published online before print August 5 2004, 10.1073/pnas.0404769101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Sabrina Cronier, Hubert Laude, and Jean-Michel Peyrin

Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death
PNAS 2004 101: 12271-12276; published online before print August 9 2004, 10.1073/pnas.0402725101 [Abstract] [Full Text] [PDF]  

Shinichi Kanno, Peter K. M. Kim, Karim Sallam, Jing Lei, Timothy R. Billiar, and Larry L. Shears, II

Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells
PNAS 2004 101: 12277-12281; published online before print August 10 2004, 10.1073/pnas.0401557101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Alok S. Pachori, Luis G. Melo, Melanie L. Hart, Nicholas Noiseux, Lunan Zhang, Fulvio Morello, Scott D. Solomon, Gregory L. Stahl, Richard E. Pratt, and Victor J. Dzau

Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury
PNAS 2004 101: 12282-12287; published online before print August 9 2004, 10.1073/pnas.0404616101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kathryn E. Luker, Matthew C. P. Smith, Gary D. Luker, Seth T. Gammon, Helen Piwnica-Worms, and David Piwnica-Worms

Kinetics of regulated protein–protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
PNAS 2004 101: 12288-12293; published online before print July 29 2004, 10.1073/pnas.0404041101 [Abstract] [Full Text] [PDF]  

Vasilis Ntziachristos, Eyk A. Schellenberger, Jorge Ripoll, Doreen Yessayan, Edward Graves, Alexei Bogdanov, Jr., Lee Josephson, and Ralph Weissleder

Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V–Cy5.5 conjugate
PNAS 2004 101: 12294-12299; published online before print August 10 2004, 10.1073/pnas.0401137101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Giuseppe Bonapace, Abdul Waheed, Gul N. Shah, and William S. Sly

Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17
PNAS 2004 101: 12300-12305; published online before print August 4 2004, 10.1073/pnas.0404764101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Microbiology

Yuchen Han, Stephan Braatsch, Lisa Osterloh, and Gabriele Klug

A eukaryotic BLUF domain mediates light-dependent gene expression in the purple bacterium Rhodobacter sphaeroides 2.4.1
PNAS 2004 101: 12306-12311; published online before print August 3 2004, 10.1073/pnas.0403547101 [Abstract] [Full Text] [PDF]  

Taeok Bae, Alison K. Banger, Adam Wallace, Elizabeth M. Glass, Fredrik Åslund, Olaf Schneewind, and Dominique M. Missiakas

Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing
PNAS 2004 101: 12312-12317; published online before print August 10 2004, 10.1073/pnas.0404728101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Angelika Gründling, Laura S. Burrack, H. G. Archie Bouwer, and Darren E. Higgins From the Cover: Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence PNAS 2004 101: 12318-12323; published online before print August 9 2004, 10.1073/pnas.0404924101 [Abstract] [Full Text] [PDF] [Supporting Information]

Yoshiaki Nishimura, Tatsuhiko Igarashi, Olivia K. Donau, Alicia Buckler-White, Charles Buckler, Bernard A. P. Lafont, Robert M. Goeken, Simoy Goldstein, Vanessa M. Hirsch, and Malcolm A. Martin Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses PNAS 2004 101: 12324-12329; published online before print August 5 2004, 10.1073/pnas.0404620101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Akiko Murakami, Hitoshi Nakatogawa, and Koreaki Ito Translation arrest of SecM is essential for the basal and regulated expression of SecA PNAS 2004 101: 12330-12335; published online before print August 9 2004, 10.1073/pnas.0404907101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Neuroscience

Steven P. Nilsen, Yick-Bun Chan, Robert Huber, and Edward A. Kravitz

Gender-selective patterns of aggressive behavior in Drosophila melanogaster
PNAS 2004 101: 12342-12347; published online before print August 9 2004, 10.1073/pnas.0404693101 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Karunesh Ganguly and David Kleinfeld

Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat
PNAS 2004 101: 12348-12353; published online before print August 5 2004, 10.1073/pnas.0308470101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lee-Ming Kow and Donald W. Pfaff

The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions
PNAS 2004 101: 12354-12357; published online before print August 9 2004, 10.1073/pnas.0404889101 [Abstract] [Full Text] [PDF]  

Christina S. Barr, Timothy K. Newman, Melanie Schwandt, Courtney Shannon, Rachel L. Dvoskin, Stephen G. Lindell, Julie Taubman, Bill Thompson, Maribeth Champoux, Klaus Peter Lesch, David Goldman, Stephen J. Suomi, and J. Dee Higley

Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
PNAS 2004 101: 12358-12363; published online before print August 9 2004, 10.1073/pnas.0403763101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Pharmacology

Scott J. Cruikshank, Matthew Hopperstad, Meg Younger, Barry W. Connors, David C. Spray, and Miduturu Srinivas

Potent block of Cx36 and Cx50 gap junction channels by mefloquine
PNAS 2004 101: 12364-12369; published online before print August 5 2004, 10.1073/pnas.0402044101 [Abstract] [Full Text] [PDF]  

Physiology

Joseph F. Hoffman, Alicia Dodson, Amittha Wickrema, and Sulayman D. Dib-Hajj

Tetrodotoxin-sensitive Na⁺ channels and muscarinic and purinergic receptors identified in human erythroid progenitor cells and red blood cell ghosts
PNAS 2004 101: 12370-12374; published online before print August 3 2004, 10.1073/pnas.0404228101 [Abstract] [Full Text] [PDF]  

Plant Biology

Giovanni Finazzi, Giles N. Johnson, Luca Dall'Osto, Pierre Joliot, Francis-André Wollman, and Roberto Bassi

A zeaxanthin-independent nonphotochemical quenching mechanism localized in the photosystem II core complex
PNAS 2004 101: 12375-12380; published online before print August 10 2004, 10.1073/pnas.0404798101 [Abstract] [Full Text] [PDF]  

Stefan Kepinski and Ottoline Leyser

Auxin-induced SCF^TIR1–Aux/IAA interaction involves stable modification of the SCF^TIR1 complex
PNAS 2004 101: 12381-12386; published online before print August 4 2004, 10.1073/pnas.0402868101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Population Biology

Peter Savolainen, Thomas Leitner, Alan N. Wilton, Elizabeth Matisoo-Smith, and Joakim Lundeberg

A detailed picture of the origin of the Australian dingo, obtained from the study of mitochondrial DNA
PNAS 2004 101: 12387-12390; published online before print August 6 2004, 10.1073/pnas.0401814101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

CORRECTIONS

Correction for Sievers et al., From the Cover: The ribosome as an entropy trap, PNAS 2004 101:7897-7901 [Extract] [Full Text] [PDF]