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COMMENTARIES

Jiunn-Liang Chen and Carol W. Greider

An emerging consensus for telomerase RNA structure
PNAS 2004 101: 14683-14684; published online before print October 4 2004, 10.1073/pnas.0406204101 [Extract] [Full Text] [PDF]  
See companion article on page 14713

Michael Bindschadler and James L. McGrath

Formin' new ideas about actin filament generation
PNAS 2004 101: 14685-14686; published online before print October 4 2004, 10.1073/pnas.0406317101 [Extract] [Full Text] [PDF]  
See companion article on page 14725

Matthew H. Davis

Units of representation in visual word recognition
PNAS 2004 101: 14687-14688; published online before print October 4 2004, 10.1073/pnas.0405788101 [Extract] [Full Text] [PDF]  
See companion article on page 14984

PHYSICAL SCIENCES

Chemistry

Sergei V. Krivov and Martin Karplus

Hidden complexity of free energy surfaces for peptide (protein) folding
PNAS 2004 101: 14766-14770; published online before print October 4 2004, 10.1073/pnas.0406234101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Physics

Johannes Berg and Michael Lässig

Local graph alignment and motif search in biological networks
PNAS 2004 101: 14689-14694; published online before print September 24 2004, 10.1073/pnas.0305199101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Florian Schindler, John M. Lupton, Jochen Feldmann, and Ullrich Scherf A universal picture of chromophores in -conjugated polymers derived from single-molecule spectroscopy PNAS 2004 101: 14695-14700; published online before print October 5 2004, 10.1073/pnas.0403325101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

SOCIAL SCIENCES

Psychology

BIOLOGICAL SCIENCES

Applied Biological Sciences

Min Dong, William H. Tepp, Eric A. Johnson, and Edwin R. Chapman

Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells
PNAS 2004 101: 14701-14706; published online before print October 1 2004, 10.1073/pnas.0404107101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Lauren J. Schwimmer, Priyanka Rohatgi, Bahareh Azizi, Katherine L. Seley, and Donald F. Doyle

Creation and discovery of ligand–receptor pairs for transcriptional control with small molecules
PNAS 2004 101: 14707-14712; published online before print September 29 2004, 10.1073/pnas.0400884101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biochemistry

Konstantin I. Pyatkov, Irina R. Arkhipova, Natalia V. Malkova, David J. Finnegan, and Michael B. Evgen'ev

Reverse transcriptase and endonuclease activities encoded by Penelope-like retroelements
PNAS 2004 101: 14719-14724; published online before print October 1 2004, 10.1073/pnas.0406281101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

Kumiko Sakata-Sogawa and Nobuo Shimamoto

RNA polymerase can track a DNA groove during promoter search
PNAS 2004 101: 14731-14735; published online before print October 6 2004, 10.1073/pnas.0406441101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kazuhito Itoh and Masaki Sasai

Dynamical transition and proteinquake in photoactive yellow protein
PNAS 2004 101: 14736-14741; published online before print October 4 2004, 10.1073/pnas.0402978101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Navin Khaneja, Jr-Shin Li, Cindie Kehlet, Burkhard Luy, and Steffen J. Glaser

Broadband relaxation-optimized polarization transfer in magnetic resonance
PNAS 2004 101: 14742-14747; published online before print October 4 2004, 10.1073/pnas.0404820101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jason E. Ollerenshaw, Hüseyin Kaya, Hue Sun Chan, and Lewis E. Kay

Sparsely populated folding intermediates of the Fyn SH3 domain: Matching native-centric essential dynamics and experiment
PNAS 2004 101: 14748-14753; published online before print October 5 2004, 10.1073/pnas.0404436101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Florencio Pazos and Michael J. E. Sternberg

Automated prediction of protein function and detection of functional sites from structure
PNAS 2004 101: 14754-14759; published online before print September 29 2004, 10.1073/pnas.0404569101 [Abstract] [Full Text] [PDF] [Supporting Information]  

D. K. Klimov, John E. Straub, and D. Thirumalai

Aqueous urea solution destabilizes A_16–22 oligomers
PNAS 2004 101: 14760-14765; published online before print October 1 2004, 10.1073/pnas.0404570101 [Abstract] [Full Text] [PDF]  

Sergei V. Krivov and Martin Karplus

Hidden complexity of free energy surfaces for peptide (protein) folding
PNAS 2004 101: 14766-14770; published online before print October 4 2004, 10.1073/pnas.0406234101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sergei Y. Ponomarev, Kelly M. Thayer, and David L. Beveridge

Ion motions in molecular dynamics simulations on DNA
PNAS 2004 101: 14771-14775; published online before print October 1 2004, 10.1073/pnas.0406435101 [Abstract] [Full Text] [PDF]  

Mathias W. Hofmann, Katrin Weise, Julian Ollesch, Prashant Agrawal, Holger Stalz, Walter Stelzer, Frans Hulsbergen, Huub de Groot, Klaus Gerwert, Jennifer Reed, and Dieter Langosch

De novo design of conformationally flexible transmembrane peptides driving membrane fusion
PNAS 2004 101: 14776-14781; published online before print September 29 2004, 10.1073/pnas.0405175101 [Abstract] [Full Text] [PDF]  

Cell Biology

Erika Suzuki, Kazuko Handa, Marcos S. Toledo, and Senitiroh Hakomori

Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert
PNAS 2004 101: 14788-14793; published online before print October 4 2004, 10.1073/pnas.0406536101 [Abstract] [Full Text] [PDF]  

Developmental Biology

Murat Bastepe, Lee S. Weinstein, Naoshi Ogata, Hiroshi Kawaguchi, Harald Jüppner, Henry M. Kronenberg, and Ung-il Chung

Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo
PNAS 2004 101: 14794-14799; published online before print September 30 2004, 10.1073/pnas.0405091101 [Abstract] [Full Text] [PDF]  

Vincenzo Zappavigna, Federica Piccioni, J. Carlos Villaescusa, and Arturo C. Verrotti

Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development
PNAS 2004 101: 14800-14805; published online before print October 1 2004, 10.1073/pnas.0406451101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Larisa Melnikova, François Juge, Natalia Gruzdeva, Aleksandr Mazur, Giacomo Cavalli, and Pavel Georgiev

Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila
PNAS 2004 101: 14806-14811; published online before print October 1 2004, 10.1073/pnas.0403959101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Ecology

Evolution

Joseph P. Bielawski, Katherine A. Dunn, Gazalah Sabehi, and Oded Béjà

Darwinian adaptation of proteorhodopsin to different light intensities in the marine environment
PNAS 2004 101: 14824-14829; published online before print October 4 2004, 10.1073/pnas.0403999101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Christopher M. Parry, Alfrun Erkner, and Johannes le Coutre

Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees
PNAS 2004 101: 14830-14834; published online before print October 4 2004, 10.1073/pnas.0404894101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Johannes Berg and Michael Lässig

Local graph alignment and motif search in biological networks
PNAS 2004 101: 14689-14694; published online before print September 24 2004, 10.1073/pnas.0305199101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Antonella Consiglio, Angela Gritti, Diego Dolcetta, Antonia Follenzi, Claudio Bordignon, Fred H. Gage, Angelo Luigi Vescovi, and Luigi Naldini From the Cover: Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors PNAS 2004 101: 14835-14840; published online before print October 4 2004, 10.1073/pnas.0404180101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Hansen Du, Daniel F. Tardiff, Melissa J. Moore, and Michael Rosbash

Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
PNAS 2004 101: 14841-14846; published online before print October 1 2004, 10.1073/pnas.0406319101 [Abstract] [Full Text] [PDF]  

Samuel K. Wasser, Andrew M. Shedlock, Kenine Comstock, Elaine A. Ostrander, Benezeth Mutayoba, and Matthew Stephens From the Cover: Assigning African elephant DNA to geographic region of origin: Applications to the ivory trade PNAS 2004 101: 14847-14852; published online before print September 30 2004, 10.1073/pnas.0403170101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Yen K. Lieu, Atul Kumar, Anthony G. Pajerowski, Thomas J. Rogers, and E. Premkumar Reddy Requirement of c-myb in T cell development and in mature T cell function PNAS 2004 101: 14853-14858; published online before print October 4 2004, 10.1073/pnas.0405338101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Immunology

Katsuji Sugie, Myung-Shin Jeon, and Howard M. Grey

Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling
PNAS 2004 101: 14859-14864; published online before print October 1 2004, 10.1073/pnas.0406168101 [Abstract] [Full Text] [PDF] [Supporting figures]  

Medical Sciences

Ekaterina Dadachova, Joshua D. Nosanchuk, Li Shi, Andrew D. Schweitzer, Annie Frenkel, Jerome S. Nosanchuk, and Arturo Casadevall

Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin
PNAS 2004 101: 14865-14870; published online before print October 5 2004, 10.1073/pnas.0406180101 [Abstract] [Full Text] [PDF]  

Guohao Dai, Mohammad R. Kaazempur-Mofrad, Sripriya Natarajan, Yuzhi Zhang, Saran Vaughn, Brett R. Blackman, Roger D. Kamm, Guillermo García-Cardeña, and Michael A. Gimbrone, Jr. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature PNAS 2004 101: 14871-14876; published online before print October 4 2004, 10.1073/pnas.0406073101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Kristopher T. Kahle, Gordon G. MacGregor, Frederick H. Wilson, Alfred N. Van Hoek, Dennis Brown, Thomas Ardito, Michael Kashgarian, Gerhard Giebisch, Steven C. Hebert, Emile L. Boulpaep, and Richard P. Lifton

Paracellular Cl^- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension
PNAS 2004 101: 14877-14882; published online before print October 1 2004, 10.1073/pnas.0406172101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Péter Hamar, Erwei Song, Gabor Kökény, Allen Chen, Nengtai Ouyang, and Judy Lieberman

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury
PNAS 2004 101: 14883-14888; published online before print October 4 2004, 10.1073/pnas.0406421101 [Abstract] [Full Text] [PDF]  

Akira Ono, Sherimay D. Ablan, Stephen J. Lockett, Kunio Nagashima, and Eric O. Freed

Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane
PNAS 2004 101: 14889-14894; published online before print October 1 2004, 10.1073/pnas.0405596101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Wen Ning, Chao-Jun Li, Naftali Kaminski, Carol A. Feghali-Bostwick, Sean M. Alber, Yuanpu P. Di, Sherrie L. Otterbein, Ruiping Song, Shizu Hayashi, Zhihong Zhou, David J. Pinsky, Simon C. Watkins, Joseph M. Pilewski, Frank C. Sciurba, David G. Peters, James C. Hogg, and Augustine M. K. Choi Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease PNAS 2004 101: 14895-14900; published online before print October 5 2004, 10.1073/pnas.0401168101 [Abstract] [Full Text] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE

Peter L. Oliver, Emmanuelle Bitoun, Joanne Clark, Emma L. Jones, and Kay E. Davies Mediation of Af4 protein function in the cerebellum by Siah proteins PNAS 2004 101: 14901-14906; published online before print September 30 2004, 10.1073/pnas.0406196101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Michael Brines, Giovanni Grasso, Fabio Fiordaliso, Alessandra Sfacteria, Pietro Ghezzi, Maddalena Fratelli, Roberto Latini, Qiao-wen Xie, John Smart, Chiao-ju Su-Rick, Eileen Pobre, Deborah Diaz, Daniel Gomez, Carla Hand, Thomas Coleman, and Anthony Cerami

Erythropoietin mediates tissue protection through an erythropoietin and common -subunit heteroreceptor
PNAS 2004 101: 14907-14912; published online before print September 29 2004, 10.1073/pnas.0406491101 [Abstract] [Full Text] [PDF]  

Margaret T. Chen, Jean-Noel Billaud, Matti Sällberg, Luca G. Guidotti, Francis V. Chisari, Joyce Jones, Janice Hughes, and David R. Milich

A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen
PNAS 2004 101: 14913-14918; published online before print October 5 2004, 10.1073/pnas.0406282101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Microbiology

Jun Ishikawa, Atsushi Yamashita, Yuzuru Mikami, Yasutaka Hoshino, Haruyo Kurita, Kunimoto Hotta, Tadayoshi Shiba, and Masahira Hattori

The complete genomic sequence of Nocardia farcinica IFM 10152
PNAS 2004 101: 14925-14930; published online before print October 4 2004, 10.1073/pnas.0406410101 [Abstract] [Full Text] [PDF]  

Teresa Gil Carvalho, Sabine Thiberge, Hiroshi Sakamoto, and Robert Ménard Conditional mutagenesis using site-specific recombination in Plasmodium berghei PNAS 2004 101: 14931-14936; published online before print October 1 2004, 10.1073/pnas.0404416101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Neuroscience

Yann Bernardinelli, Pierre J. Magistretti, and Jean-Yves Chatton

Astrocytes generate Na⁺-mediated metabolic waves
PNAS 2004 101: 14937-14942; published online before print October 4 2004, 10.1073/pnas.0405315101 [Abstract] [Full Text] [PDF] [Supporting Movie]  

Luk Chong Yeung, Harel Z. Shouval, Brian S. Blais, and Leon N. Cooper Synaptic homeostasis and input selectivity follow from a calcium-dependent plasticity model PNAS 2004 101: 14943-14948; published online before print October 4 2004, 10.1073/pnas.0405555101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Teruo Hayashi and Tsung-Ping Su Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation PNAS 2004 101: 14949-14954; published online before print October 4 2004, 10.1073/pnas.0402890101 [Abstract] [Full Text] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Anastasia P. Grigorenko, Yuri K. Moliaka, Martha C. Soto, Craig C. Mello, and Evgeny I. Rogaev

The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
PNAS 2004 101: 14955-14960; published online before print October 6 2004, 10.1073/pnas.0406462101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Eugene M. Martin, Morris F. West, and Purvis H. Bedenbaugh

Masking and scrambling in the auditory thalamus of awake rats by Gaussian and modulated noises
PNAS 2004 101: 14961-14965; published online before print September 27 2004, 10.1073/pnas.0306879101 [Abstract] [Full Text] [PDF]  

Sreeganga Chandra, Francesco Fornai, Hyung-Bae Kwon, Umar Yazdani, Deniz Atasoy, Xinran Liu, Robert E. Hammer, Giuseppe Battaglia, Dwight C. German, Pablo E. Castillo, and Thomas C. Südhof

Double-knockout mice for - and -synucleins: Effect on synaptic functions
PNAS 2004 101: 14966-14971; published online before print October 1 2004, 10.1073/pnas.0406283101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Wee-Ming Boon, Tim Beissbarth, Lavinia Hyde, Gordon Smyth, Jenny Gunnersen, Derek A. Denton, Hamish Scott, and Seong-Seng Tan

A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering
PNAS 2004 101: 14972-14977; published online before print October 4 2004, 10.1073/pnas.0406296101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Plant Biology

Joshua I. Armstrong, Shiaulou Yuan, Joseph M. Dale, Vanessa N. Tanner, and Athanasios Theologis

Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis
PNAS 2004 101: 14978-14983; published online before print October 4 2004, 10.1073/pnas.0404312101 [Abstract] [Full Text] [PDF] [Supporting Information]  

CORRECTIONS

errata for VanBuren et al., Estimates of lateral and longitudinal bond energies within the microtubule lattice, PNAS 2002 99:6035-6040 [Extract] [Full Text] [PDF]