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FROM THE ACADEMY

Nicholas R. Cozzarelli, Kenneth R. Fulton, and Diane M. Sullenberger

Editorial: National Academy of Sciences endorses National Institutes of Health plan for enhanced access to research information
PNAS 2004 101: 14991; published online before print October 12 2004, 10.1073/pnas.0407071101 [Extract] [Full Text] [PDF]  

COMMENTARIES

Michael J. Waters and Becky L. Conway-Campbell

The oncogenic potential of autocrine human growth hormone in breast cancer
PNAS 2004 101: 14992-14993; published online before print October 12 2004, 10.1073/pnas.0406396101 [Extract] [Full Text] [PDF]  
See companion article on page 15166

Grant McFadden

Smallpox: An ancient disease enters the modern era of virogenomics
PNAS 2004 101: 14994-14995; published online before print October 12 2004, 10.1073/pnas.0406207101 [Extract] [Full Text] [PDF]  
See companion article on page 15190
See companion article on page 15196

John Browse and B. Markus Lange

Counting the cost of a cold-blooded life: Metabolomics of cold acclimation
PNAS 2004 101: 14996-14997; published online before print October 12 2004, 10.1073/pnas.0406389101 [Extract] [Full Text] [PDF]  
See companion article on page 15243

PERSPECTIVES

W. G. Ernst

Regional crustal thickness and precipitation in young mountain chains
PNAS 2004 101: 14998-15001; published online before print October 7 2004, 10.1073/pnas.0406557101 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Alexandre J. Chorin and Paul Krause

Dimensional reduction for a Bayesian filter
PNAS 2004 101: 15013-15017; published online before print October 6 2004, 10.1073/pnas.0406222101 [Abstract] [Full Text] [PDF]  

Joel E. Cohen, J. H. B. Kemperman, and Gheorghe Zbaganu

Elementary inequalities that involve two nonnegative vectors or functions
PNAS 2004 101: 15018-15022; published online before print September 27 2004, 10.1073/pnas.0405413101 [Abstract] [Full Text] [PDF]  

Grigory Isaakovich Barenblatt and Alexandre J. Chorin

A mathematical model for the scaling of turbulence
PNAS 2004 101: 15023-15026; published online before print October 6 2004, 10.1073/pnas.0406291101 [Abstract] [Full Text] [PDF]  

Chemistry

Geology

Ming Chen, Ahmed El Goresy, and Philippe Gillet

Ringwoodite lamellae in olivine: Clues to olivine–ringwoodite phase transition mechanisms in shocked meteorites and subducting slabs
PNAS 2004 101: 15033-15037; published online before print October 12 2004, 10.1073/pnas.0405048101 [Abstract] [Full Text] [PDF]  

Physics

E. H. Trepagnier, C. Jarzynski, F. Ritort, G. E. Crooks, C. J. Bustamante, and J. Liphardt

Experimental test of Hatano and Sasa's nonequilibrium steady-state equality
PNAS 2004 101: 15038-15041; published online before print October 6 2004, 10.1073/pnas.0406405101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Applied Biological Sciences

Sofia Zabalou, Markus Riegler, Marianna Theodorakopoulou, Christian Stauffer, Charalambos Savakis, and Kostas Bourtzis

Wolbachia-induced cytoplasmic incompatibility as a means for insect pest population control
PNAS 2004 101: 15042-15045; published online before print October 6 2004, 10.1073/pnas.0403853101 [Abstract] [Full Text] [PDF]  

Biochemistry

Fumihiro Motojima, Charu Chaudhry, Wayne A. Fenton, George W. Farr, and Arthur L. Horwich Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL PNAS 2004 101: 15005-15012; published online before print October 12 2004, 10.1073/pnas.0406132101 [Abstract] [Full Text] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Christopher Cianci, David R. Langley, Douglas D. Dischino, Yaxiong Sun, Kuo-Long Yu, Anne Stanley, Julia Roach, Zhufang Li, Richard Dalterio, Richard Colonno, Nicholas A. Meanwell, and Mark Krystal Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion PNAS 2004 101: 15046-15051; published online before print October 6 2004, 10.1073/pnas.0406696101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Takao Hibi, Hiroshi Nii, Toru Nakatsu, Akira Kimura, Hiroaki Kato, Jun Hiratake, and Jun'ichi Oda Crystal structure of -glutamylcysteine synthetase: Insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis PNAS 2004 101: 15052-15057; published online before print October 11 2004, 10.1073/pnas.0403277101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Loretta L. Collins, Yi-Fen Lee, Cynthia A. Heinlein, Ning-Chun Liu, Yei-Tsung Chen, Chih-Rong Shyr, Charles K. Meshul, Hideo Uno, Kenneth A. Platt, and Chawnshang Chang

Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4
PNAS 2004 101: 15058-15063; published online before print October 11 2004, 10.1073/pnas.0405700101 [Abstract] [Full Text] [PDF]  

Alessandro Vannini, Cinzia Volpari, Gessica Filocamo, Elena Caroli Casavola, Mirko Brunetti, Debora Renzoni, Prasun Chakravarty, Chantal Paolini, Raffaele De Francesco, Paola Gallinari, Christian Steinkühler, and Stefania Di Marco

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor
PNAS 2004 101: 15064-15069; published online before print October 11 2004, 10.1073/pnas.0404603101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yohei Kirino, Takehiro Yasukawa, Shigeo Ohta, Shigeo Akira, Kaisuke Ishihara, Kimitsuna Watanabe, and Tsutomu Suzuki

Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease
PNAS 2004 101: 15070-15075; published online before print October 11 2004, 10.1073/pnas.0405173101 [Abstract] [Full Text] [PDF]  

Biophysics

Seiji Takeuchi, Wengeng Zhang, Kazumasa Wakamatsu, Shosuke Ito, Vincent J. Hearing, Kenneth H. Kraemer, and Douglas E. Brash

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin
PNAS 2004 101: 15076-15081; published online before print October 11 2004, 10.1073/pnas.0403994101 [Abstract] [Full Text] [PDF]  

Monique Dubois, Vladimir Lizunov, Annette Meister, Thadeus Gulik-Krzywicki, Jean Marc Verbavatz, Emile Perez, Joshua Zimmerberg, and Thomas Zemb Shape control through molecular segregation in giant surfactant aggregates PNAS 2004 101: 15082-15087; published online before print October 12 2004, 10.1073/pnas.0400837101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

M. R. Ejtehadi, S. P. Avall, and S. S. Plotkin

Three-body interactions improve the prediction of rate and mechanism in protein folding models
PNAS 2004 101: 15088-15093; published online before print October 6 2004, 10.1073/pnas.0403486101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sagar D. Khare, Michael Caplow, and Nikolay V. Dokholyan

The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis
PNAS 2004 101: 15094-15099; published online before print October 8 2004, 10.1073/pnas.0406650101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cell Biology

Dun Yang, Alana Welm, and J. Michael Bishop

Cell division and cell survival in the absence of survivin
PNAS 2004 101: 15100-15105; published online before print October 11 2004, 10.1073/pnas.0406665101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Danyang Chen, Andrew S. Belmont, and Sui Huang

Upstream binding factor association induces large-scale chromatin decondensation
PNAS 2004 101: 15106-15111; published online before print October 11 2004, 10.1073/pnas.0404767101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

David A. Schneider and Masayasu Nomura

RNA polymerase I remains intact without subunit exchange through multiple rounds of transcription in Saccharomyces cerevisiae
PNAS 2004 101: 15112-15117; published online before print October 11 2004, 10.1073/pnas.0406746101 [Abstract] [Full Text] [PDF]  

Developmental Biology

Tetsuro Ikuta, Natsue Yoshida, Nori Satoh, and Hidetoshi Saiga

Ciona intestinalis Hox gene cluster: Its dispersed structure and residual colinear expression in development
PNAS 2004 101: 15118-15123; published online before print October 6 2004, 10.1073/pnas.0401389101 [Abstract] [Full Text] [PDF]  

Ecology

L. Hufnagel, D. Brockmann, and T. Geisel

Forecast and control of epidemics in a globalized world
PNAS 2004 101: 15124-15129; published online before print October 11 2004, 10.1073/pnas.0308344101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Debra P. C. Peters, Roger A. Pielke, Sr., Brandon T. Bestelmeyer, Craig D. Allen, Stuart Munson-McGee, and Kris M. Havstad Cross-scale interactions, nonlinearities, and forecasting catastrophic events PNAS 2004 101: 15130-15135; published online before print October 6 2004, 10.1073/pnas.0403822101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Hans-Peter Horz, Adrian Barbrook, Christopher B. Field, and Brendan J. M. Bohannan

Ammonia-oxidizing bacteria respond to multifactorial global change
PNAS 2004 101: 15136-15141; published online before print October 6 2004, 10.1073/pnas.0406616101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Christopher M. Seabury, Rodney L. Honeycutt, Alejandro P. Rooney, Natalie D. Halbert, and James N. Derr

Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3
PNAS 2004 101: 15142-15147; published online before print October 11 2004, 10.1073/pnas.0406403101 [Abstract] [Full Text] [PDF]  

Michael Krauthammer, Charles A. Kaufmann, T. Conrad Gilliam, and Andrey Rzhetsky Molecular triangulation: Bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease PNAS 2004 101: 15148-15153; published online before print October 7 2004, 10.1073/pnas.0404315101 [Abstract] [Full Text] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE

Immunology

SangKon Oh, Liyanage P. Perera, Donald S. Burke, Thomas A. Waldmann, and Jay A. Berzofsky

IL-15/IL-15R-mediated avidity maturation of memory CD8⁺ T cells
PNAS 2004 101: 15154-15159; published online before print October 11 2004, 10.1073/pnas.0406649101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Medical Sciences

Gabor L. Toller, Judit E. Horvath, Andrew V. Schally, Gabor Halmos, Jozsef L. Varga, Kate Groot, David Chism, and Marta Zarandi

Development of a polyclonal antiserum for the detection of the isoforms of the receptors for human growth hormone-releasing hormone on tumors
PNAS 2004 101: 15160-15165; published online before print October 6 2004, 10.1073/pnas.0406348101 [Abstract] [Full Text] [PDF]  

Svetlana Mukhina, Hichem C. Mertani, Ke Guo, Kok-Onn Lee, Peter D. Gluckman, and Peter E. Lobie From The Cover: Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone PNAS 2004 101: 15166-15171; published online before print September 7 2004, 10.1073/pnas.0405881101 [Abstract] [Full Text] [PDF]   See Commentary on page 14992

Nishant Agrawal, Chetan Bettegowda, Ian Cheong, Jean-Francois Geschwind, Charles G. Drake, Edward L. Hipkiss, Mitsuaki Tatsumi, Long H. Dang, Luis A. Diaz, Jr., Martin Pomper, Mohammad Abusedera, Richard L. Wahl, Kenneth W. Kinzler, Shibin Zhou, David L. Huso, and Bert Vogelstein Bacteriolytic therapy can generate a potent immune response against experimental tumors PNAS 2004 101: 15172-15177; published online before print October 7 2004, 10.1073/pnas.0406242101 [Abstract] [Full Text] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Nan Chiang, Edmund A. Bermudez, Paul M. Ridker, Shelley Hurwitz, and Charles N. Serhan Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial PNAS 2004 101: 15178-15183; published online before print October 7 2004, 10.1073/pnas.0405445101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Timothy S. Fenske, Gina Pengue, Vikram Mathews, Piia T. Hanson, Sarah E. Hamm, Noor Riaz, and Timothy A. Graubert

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice
PNAS 2004 101: 15184-15189; published online before print October 11 2004, 10.1073/pnas.0400751101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Microbiology

Peter B. Jahrling, Lisa E. Hensley, Mark J. Martinez, James W. LeDuc, Kathleen H. Rubins, David A. Relman, and John W. Huggins From The Cover: Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox PNAS 2004 101: 15196-15200; published online before print October 11 2004, 10.1073/pnas.0405954101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE   See Commentary on page 14994

Neuroscience

Robert Lu, Houping Wang, Zhe Liang, Li Ku, William T. O'Donnell, Wen Li, Stephen T. Warren, and Yue Feng

The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development
PNAS 2004 101: 15201-15206; published online before print October 8 2004, 10.1073/pnas.0404995101 [Abstract] [Full Text] [PDF]  

Sheng Xia, Svend Kjær, Kang Zheng, Ping-Sheng Hu, Li Bai, Jun-Yong Jia, Rudolf Rigler, Aladdin Pramanik, Tao Xu, Tomas Hökfelt, and Zhi-Qing David Xu

Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: Constitutive and ligand-induced internalization
PNAS 2004 101: 15207-15212; published online before print October 7 2004, 10.1073/pnas.0406571101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Hong Yang and Sam Kunes

Nonvesicular release of acetylcholine is required for axon targeting in the Drosophila visual system
PNAS 2004 101: 15213-15218; published online before print October 5 2004, 10.1073/pnas.0308141101 [Abstract] [Full Text] [PDF]  

Amy B. Harkins, Anne L. Cahill, James F. Powers, Arthur S. Tischler, and Aaron P. Fox

Deletion of the synaptic protein interaction site of the N-type (Ca_V2.2) calcium channel inhibits secretion in mouse pheochromocytoma cells
PNAS 2004 101: 15219-15224; published online before print October 7 2004, 10.1073/pnas.0401001101 [Abstract] [Full Text] [PDF]  

Pharmacology

Physiology

Joseph M. Scandura, Piernicola Boccuni, Joan Massagué, and Stephen D. Nimer

Transforming growth factor -induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation
PNAS 2004 101: 15231-15236; published online before print October 11 2004, 10.1073/pnas.0406771101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Sang-Ho Kwon and William B. Guggino

Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization
PNAS 2004 101: 15237-15242; published online before print October 5 2004, 10.1073/pnas.0404877101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Plant Biology

Emmanuel Delhaize, Peter R. Ryan, Diane M. Hebb, Yoko Yamamoto, Takayuki Sasaki, and Hideaki Matsumoto

Engineering high-level aluminum tolerance in barley with the ALMT1 gene
PNAS 2004 101: 15249-15254; published online before print October 7 2004, 10.1073/pnas.0406258101 [Abstract] [Full Text] [PDF]  

Garth R. Brown, Geoffrey P. Gill, Robert J. Kuntz, Charles H. Langley, and David B. Neale

Nucleotide diversity and linkage disequilibrium in loblolly pine
PNAS 2004 101: 15255-15260; published online before print October 11 2004, 10.1073/pnas.0404231101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Population Biology

Derek Spielman, Barry W. Brook, and Richard Frankham

Most species are not driven to extinction before genetic factors impact them
PNAS 2004 101: 15261-15264; published online before print October 11 2004, 10.1073/pnas.0403809101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Psychology

CORRECTIONS

Correction for Zerbini et al., NF-B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45 and is essential for cancer cell survival, PNAS 2004 101:13618-13623 [Extract] [Full Text] [PDF]  

Correction for Bill et al., Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration, PNAS 2004 101:11135-11140 [Extract] [Full Text] [PDF]  

Retraction for Martens et al., Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy, PNAS 1998 95:2664-2669 [Extract] [Full Text] [PDF]