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COMMENTARIES

Graciela Spivak

The many faces of Cockayne syndrome
PNAS 2004 101: 15273-15274; published online before print October 19 2004, 10.1073/pnas.0406894101 [Extract] [Full Text] [PDF]  
See companion article on page 15410

PHYSICAL SCIENCES

Chemistry

Antoine Richard, Valérie Marchi-Artzner, Marie-Noëlle Lalloz, Marie-Josèphe Brienne, Franck Artzner, Thaddée Gulik-Krzywicki, Marie-Alice Guedeau-Boudeville, and Jean-Marie Lehn

Fusogenic supramolecular vesicle systems induced by metal ion binding to amphiphilic ligands
PNAS 2004 101: 15279-15284; published online before print October 18 2004, 10.1073/pnas.0406625101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geology

Oliver Heiri, Willy Tinner, and André F. Lotter

Evidence for cooler European summers during periods of changing meltwater flux to the North Atlantic
PNAS 2004 101: 15285-15288; published online before print October 18 2004, 10.1073/pnas.0406594101 [Abstract] [Full Text] [PDF] [Supporting Information]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Agricultural Sciences

Hong-Kyu Choi, Jeong-Hwan Mun, Dong-Jin Kim, Hongyan Zhu, Jong-Min Baek, Joanne Mudge, Bruce Roe, Noel Ellis, Jeff Doyle, Gyorgy B. Kiss, Nevin D. Young, and Douglas R. Cook

Estimating genome conservation between crop and model legume species
PNAS 2004 101: 15289-15294; published online before print October 15 2004, 10.1073/pnas.0402251101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Applied Biological Sciences

Frauke Rininsland, Wensheng Xia, Shannon Wittenburg, Xiaobo Shi, Casey Stankewicz, Komandoor Achyuthan, Duncan McBranch, and David Whitten

Metal ion-mediated polymer superquenching for highly sensitive detection of kinase and phosphatase activities
PNAS 2004 101: 15295-15300; published online before print October 19 2004, 10.1073/pnas.0406832101 [Abstract] [Full Text] [PDF]  

Biochemistry

Tímea Gérczei and Carl C. Correll

Imp3p and Imp4p mediate formation of essential U3–precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA
PNAS 2004 101: 15301-15306; published online before print October 15 2004, 10.1073/pnas.0406819101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Timothy A. Fritz, James H. Hurley, Loc-Ba Trinh, Joseph Shiloach, and Lawrence A. Tabak

The beginnings of mucin biosynthesis: The crystal structure of UDP-GalNAc:polypeptide -N-acetylgalactosaminyltransferase-T1
PNAS 2004 101: 15307-15312; published online before print October 14 2004, 10.1073/pnas.0405657101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Hisashi Harada, Bonnie Quearry, Antonio Ruiz-Vela, and Stanley J. Korsmeyer

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
PNAS 2004 101: 15313-15317; published online before print October 14 2004, 10.1073/pnas.0406837101 [Abstract] [Full Text] [PDF]  

Chee-Kwee Ea, Lijun Sun, Jun-Ichiro Inoue, and Zhijian J. Chen

TIFA activates IB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6
PNAS 2004 101: 15318-15323; published online before print October 18 2004, 10.1073/pnas.0404132101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Biophysics

Gerhard Hummer, Friedrich Schotte, and Philip A. Anfinrud Unveiling functional protein motions with picosecond x-ray crystallography and molecular dynamics simulations PNAS 2004 101: 15330-15334; published online before print October 15 2004, 10.1073/pnas.0405295101 [Abstract] [Full Text] [PDF] [Supporting Movies] OPEN ACCESS ARTICLE

Ruxandra I. Dima and D. Thirumalai

Probing the instabilities in the dynamics of helical fragments from mouse PrP^C
PNAS 2004 101: 15335-15340; published online before print October 19 2004, 10.1073/pnas.0404235101 [Abstract] [Full Text] [PDF]  

Christoph H. Borchers, Victor E. Marquez, Gottfried K. Schroeder, Steven A. Short, Mark J. Snider, J. Paul Speir, and Richard Wolfenden

Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex
PNAS 2004 101: 15341-15345; published online before print October 19 2004, 10.1073/pnas.0406781101 [Abstract] [Full Text] [PDF]  

Bin Qian, Angel R. Ortiz, and David Baker

Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
PNAS 2004 101: 15346-15351; published online before print October 18 2004, 10.1073/pnas.0404703101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kang Chen, Zhigang Liu, and Neville R. Kallenbach

The polyproline II conformation in short alanine peptides is noncooperative
PNAS 2004 101: 15352-15357; published online before print October 15 2004, 10.1073/pnas.0406657101 [Abstract] [Full Text] [PDF]  

Cell Biology

Megan Cully, Andrew Elia, Siew-Hwa Ong, Vuk Stambolic, Tony Pawson, Ming-Sound Tsao, and Tak W. Mak

grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten^+/- mice
PNAS 2004 101: 15358-15363; published online before print October 18 2004, 10.1073/pnas.0406613101 [Abstract] [Full Text] [PDF]  

Marcel Tuynder, Giusy Fiucci, Sylvie Prieur, Alexandra Lespagnol, Anne Géant, Séverine Beaucourt, Dominique Duflaut, Stéphanie Besse, Laurent Susini, Jean Cavarelli, Dino Moras, Robert Amson, and Adam Telerman Translationally controlled tumor protein is a target of tumor reversion PNAS 2004 101: 15364-15369; published online before print October 15 2004, 10.1073/pnas.0406776101 [Abstract] [Full Text] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Developmental Biology

Qiang Tian, Megan C. Feetham, W. Andy Tao, Xi C. He, Linheng Li, Ruedi Aebersold, and Leroy Hood

Proteomic analysis identifies that 14-3-3 interacts with -catenin and facilitates its activation by Akt
PNAS 2004 101: 15370-15375; published online before print October 18 2004, 10.1073/pnas.0406499101 [Abstract] [Full Text] [PDF]  

Evolution

Rafael Sanjuán, Andrés Moya, and Santiago F. Elena

The contribution of epistasis to the architecture of fitness in an RNA virus
PNAS 2004 101: 15376-15379; published online before print October 18 2004, 10.1073/pnas.0404125101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Patrick J. Keeling and Yuji Inagaki

A class of eukaryotic GTPase with a punctate distribution suggesting multiple functional replacements of translation elongation factor 1
PNAS 2004 101: 15380-15385; published online before print October 18 2004, 10.1073/pnas.0404505101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Emmanuel J. P. Douzery, Elizabeth A. Snell, Eric Bapteste, Frédéric Delsuc, and Hervé Philippe

The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils?
PNAS 2004 101: 15386-15391; published online before print October 19 2004, 10.1073/pnas.0403984101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Lance D. Langston and Lorraine S. Symington

Gene targeting in yeast is initiated by two independent strand invasions
PNAS 2004 101: 15392-15397; published online before print October 15 2004, 10.1073/pnas.0403748101 [Abstract] [Full Text] [PDF]  

Paul D. Thomas and Anish Kejariwal Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: Evolutionary evidence for differences in molecular effects PNAS 2004 101: 15398-15403; published online before print October 18 2004, 10.1073/pnas.0404380101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Ji-Ming Gong, David A. Waner, Tomoaki Horie, Shi Lun Li, Rie Horie, Khush B. Abid, and Julian I. Schroeder

Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana
PNAS 2004 101: 15404-15409; published online before print October 14 2004, 10.1073/pnas.0404780101 [Abstract] [Full Text] [PDF]  

Katsuyoshi Horibata, Yuka Iwamoto, Isao Kuraoka, Nicolaas G. J. Jaspers, Akihiro Kurimasa, Mitsuo Oshimura, Masamitsu Ichihashi, and Kiyoji Tanaka From The Cover: Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome PNAS 2004 101: 15410-15415; published online before print October 14 2004, 10.1073/pnas.0404587101 [Abstract] [Full Text] [PDF] [Supporting Figure]   See Commentary on page 15273

Immunology

Can Xie, Motomu Shimaoka, Tsan Xiao, Pascale Schwab, Lloyd B. Klickstein, and Timothy A. Springer

The integrin -subunit leg extends at a Ca²⁺-dependent epitope in the thigh/genu interface upon activation
PNAS 2004 101: 15422-15427; published online before print October 19 2004, 10.1073/pnas.0406680101 [Abstract] [Full Text] [PDF]  

Ziqiang Li, Zhonghui Luo, and Matthew D. Scharff

Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching
PNAS 2004 101: 15428-15433; published online before print October 14 2004, 10.1073/pnas.0406827101 [Abstract] [Full Text] [PDF]  

Jayagopala Reddy, Zsolt Illes, Xingmin Zhang, Jeffrey Encinas, Jason Pyrdol, Lindsay Nicholson, Raymond A. Sobel, Kai W. Wucherpfennig, and Vijay K. Kuchroo

Myelin proteolipid protein-specific CD4⁺CD25⁺ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis
PNAS 2004 101: 15434-15439; published online before print October 18 2004, 10.1073/pnas.0404444101 [Abstract] [Full Text] [PDF] [Supporting Information]  

David C. Jackson, Yuk Fai Lau, Thuy Le, Andreas Suhrbier, Georgia Deliyannis, Christina Cheers, Corey Smith, Weiguang Zeng, and Lorena E. Brown A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses PNAS 2004 101: 15440-15445; published online before print October 15 2004, 10.1073/pnas.0406740101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Medical Sciences

Danielle L. Krebs, Donald Metcalf, Tobias D. Merson, Anne K. Voss, Tim Thomas, Jian-Guo Zhang, Steven Rakar, Moira K. O'Bryan, Tracy A. Willson, Elizabeth M. Viney, Lisa A. Mielke, Nicos A. Nicola, Douglas J. Hilton, and Warren S. Alexander

Development of hydrocephalus in mice lacking SOCS7
PNAS 2004 101: 15446-15451; published online before print October 19 2004, 10.1073/pnas.0406870101 [Abstract] [Full Text] [PDF]  

Catherine M. Finnegan, Satinder S. Rawat, Anu Puri, Ji Ming Wang, Francis W. Ruscetti, and Robert Blumenthal

Ceramide, a target for antiretroviral therapy
PNAS 2004 101: 15452-15457; published online before print October 15 2004, 10.1073/pnas.0402874101 [Abstract] [Full Text] [PDF]  

Henri J. Vial, Sharon Wein, Christine Farenc, Clemens Kocken, Olivier Nicolas, Marie Laure Ancelin, Francoise Bressolle, Alan Thomas, and Michèle Calas Prodrugs of bisthiazolium salts are orally potent antimalarials PNAS 2004 101: 15458-15463; published online before print October 18 2004, 10.1073/pnas.0404037101 [Abstract] [Full Text] [PDF] [Supporting Text] OPEN ACCESS ARTICLE

Claire Vandiedonck, Geneviève Beaurain, Matthieu Giraud, Catherine Hue-Beauvais, Bruno Eymard, Christine Tranchant, Philippe Gajdos, Jean Dausset, and Henri-Jean Garchon

Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia
PNAS 2004 101: 15464-15469; published online before print October 15 2004, 10.1073/pnas.0406756101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Adam L. Feire, Heidi Koss, and Teresa Compton

Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain
PNAS 2004 101: 15470-15475; published online before print October 19 2004, 10.1073/pnas.0406821101 [Abstract] [Full Text] [PDF]  

Neuroscience

Nancy Kopell and Bard Ermentrout

Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks
PNAS 2004 101: 15482-15487; published online before print October 15 2004, 10.1073/pnas.0406343101 [Abstract] [Full Text] [PDF]  

W.-C. Li, S. R. Soffe, and Alan Roberts From The Cover: Glutamate and acetylcholine corelease at developing synapses PNAS 2004 101: 15488-15493; published online before print October 19 2004, 10.1073/pnas.0404864101 [Abstract] [Full Text] [PDF]

Sebastian Brauchi, Patricio Orio, and Ramon Latorre Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8 PNAS 2004 101: 15494-15499; published online before print October 18 2004, 10.1073/pnas.0406773101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

H. Burton, A. Z. Snyder, and M. E. Raichle

Default brain functionality in blind people
PNAS 2004 101: 15500-15505; published online before print October 15 2004, 10.1073/pnas.0406676101 [Abstract] [Full Text] [PDF]  

S. J. Evans, P. V. Choudary, C. R. Neal, J. Z. Li, M. P. Vawter, H. Tomita, J. F. Lopez, R. C. Thompson, F. Meng, J. D. Stead, D. M. Walsh, R. M. Myers, W. E. Bunney, S. J. Watson, E. G. Jones, and H. Akil Dysregulation of the fibroblast growth factor system in major depression PNAS 2004 101: 15506-15511; published online before print October 13 2004, 10.1073/pnas.0406788101 [Abstract] [Full Text] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE

Michael Y. Chao, Hidetoshi Komatsu, Hana S. Fukuto, Heather M. Dionne, and Anne C. Hart

Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit
PNAS 2004 101: 15512-15517; published online before print October 18 2004, 10.1073/pnas.0403369101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Susanna B. Mierau, Rhiannon M. Meredith, A. Louise Upton, and Ole Paulsen

Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex
PNAS 2004 101: 15518-15523; published online before print October 18 2004, 10.1073/pnas.0402916101 [Abstract] [Full Text] [PDF]  

Charles F. Stevens Preserving properties of object shape by computations in primary visual cortex PNAS 2004 101: 15524-15529; published online before print October 13 2004, 10.1073/pnas.0406664101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Physiology

Nenad Bursac, Felipe Aguel, and Leslie Tung

Multiarm spirals in a two-dimensional cardiac substrate
PNAS 2004 101: 15530-15534; published online before print October 18 2004, 10.1073/pnas.0400984101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Flora Jow, Zhi-Hao Zhang, David C. Kopsco, Karen C. Carroll, and KeWei Wang

Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kv1.1 A-type K⁺ channels
PNAS 2004 101: 15535-15540; published online before print October 14 2004, 10.1073/pnas.0402081101 [Abstract] [Full Text] [PDF]  

Psychology

Chi-Hung Juan, Stephanie M. Shorter-Jacobi, and Jeffrey D. Schall

Dissociation of spatial attention and saccade preparation
PNAS 2004 101: 15541-15544; published online before print October 15 2004, 10.1073/pnas.0403507101 [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for Golden, Meshing the gears of the cyanobacterial circadian clock, PNAS 2004 101:13697-13698 [Extract] [Full Text] [PDF]  

Correction for Marillonnet et al., In planta engineering of viral RNA replicons: Efficient assembly by recombination of DNA modules delivered by Agrobacterium, PNAS 2004 101:6852-6857 [Extract] [Full Text] [PDF]  

Correction for Veugelers et al., Comparative PRKAR1A genotype–phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice, PNAS 2004 101:14222-14227 [Extract] [Full Text] [PDF]