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COMMENTARIES

Stephen M. Rich

The unpredictable past of Plasmodium vivax revealed in its genome
PNAS 2004 101: 15547-15548; published online before print October 25 2004, 10.1073/pnas.0405618101 [Extract] [Full Text] [PDF]  

Adam Zlotnick

Viruses and the physics of soft condensed matter
PNAS 2004 101: 15549-15550; published online before print October 25 2004, 10.1073/pnas.0406935101 [Extract] [Full Text] [PDF]  
See companion article on page 15556

PHYSICAL SCIENCES

Applied Mathematics

Physics

Statistics

Ker-Chau Li, Ching-Ti Liu, Wei Sun, Shinsheng Yuan, and Tianwei Yu

A system for enhancing genome-wide coexpression dynamics study
PNAS 2004 101: 15561-15566; published online before print October 18 2004, 10.1073/pnas.0402962101 [Abstract] [Full Text] [PDF] [Supporting Information]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Biochemistry

Bornali Chakravarty, Ziwei Gu, Subrahmanyam S. Chirala, Salih J. Wakil, and Florante A. Quiocho

Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain
PNAS 2004 101: 15567-15572; published online before print October 26 2004, 10.1073/pnas.0406901101 [Abstract] [Full Text] [PDF]  

Sarah J. Kodumal, Kedar G. Patel, Ralph Reid, Hugo G. Menzella, Mark Welch, and Daniel V. Santi

Total synthesis of long DNA sequences: Synthesis of a contiguous 32-kb polyketide synthase gene cluster
PNAS 2004 101: 15573-15578; published online before print October 20 2004, 10.1073/pnas.0406911101 [Abstract] [Full Text] [PDF]  

Gianguido Coffa and Alan R. Brash

A single active site residue directs oxygenation stereospecificity in lipoxygenases: Stereocontrol is linked to the position of oxygenation
PNAS 2004 101: 15579-15584; published online before print October 20 2004, 10.1073/pnas.0406727101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Martin Hahn and Torsten Stachelhaus

Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains
PNAS 2004 101: 15585-15590; published online before print October 21 2004, 10.1073/pnas.0404932101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Alexander R. Horswill, Sergey N. Savinov, and Stephen J. Benkovic

A systematic method for identifying small-molecule modulators of protein–protein interactions
PNAS 2004 101: 15591-15596; published online before print October 21 2004, 10.1073/pnas.0406999101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Seiji Ishii, Katsumi IIzuka, Bonnie C. Miller, and Kosaku Uyeda

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
PNAS 2004 101: 15597-15602; published online before print October 20 2004, 10.1073/pnas.0405238101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Jen-Chywan Wang, Mika Kakefuda Derynck, Daisuke F. Nonaka, Daniel B. Khodabakhsh, Chris Haqq, and Keith R. Yamamoto From The Cover: Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes PNAS 2004 101: 15603-15608; published online before print October 22 2004, 10.1073/pnas.0407008101 [Abstract] [Full Text] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE

Longkuan Xiang, John A. Kalaitzis, and Bradley S. Moore

EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions
PNAS 2004 101: 15609-15614; published online before print October 25 2004, 10.1073/pnas.0405508101 [Abstract] [Full Text] [PDF]  

Hitoshi Sawada, Etsuko Tanaka, Susumu Ban, Chiho Yamasaki, Junko Fujino, Kazuto Ooura, Yukichi Abe, Ken-ichi Matsumoto, and Hideyoshi Yokosawa

Self/nonself recognition in ascidian fertilization: Vitelline coat protein HrVC70 is a candidate allorecognition molecule
PNAS 2004 101: 15615-15620; published online before print October 25 2004, 10.1073/pnas.0401928101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

D. Becker, D. Geiger, M. Dunkel, A. Roller, A. Bertl, A. Latz, A. Carpaneto, P. Dietrich, M. R. G. Roelfsema, C. Voelker, D. Schmidt, B. Mueller-Roeber, K. Czempinski, and R. Hedrich

AtTPK4, an Arabidopsis tandem-pore K⁺ channel, poised to control the pollen membrane voltage in a pH- and Ca²⁺-dependent manner
PNAS 2004 101: 15621-15626; published online before print October 25 2004, 10.1073/pnas.0401502101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Brad J. Nolen, Ryan S. Littlefield, and Thomas D. Pollard

Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP
PNAS 2004 101: 15627-15632; published online before print October 25 2004, 10.1073/pnas.0407149101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Paul G. Scott, Paul A. McEwan, Carole M. Dodd, Ernst M. Bergmann, Paul N. Bishop, and Jordi Bella

Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan
PNAS 2004 101: 15633-15638; published online before print October 22 2004, 10.1073/pnas.0402976101 [Abstract] [Full Text] [PDF] [Supporting Information]  

W. Kevin Meisner and Tobin R. Sosnick

Barrier-limited, microsecond folding of a stable protein measured with hydrogen exchange: Implications for downhill folding
PNAS 2004 101: 15639-15644; published online before print October 25 2004, 10.1073/pnas.0404895101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Berta M. Martins, Holger Dobbek, Irfan Çinkaya, Wolfgang Buckel, and Albrecht Messerschmidt

Crystal structure of 4-hydroxybutyryl-CoA dehydratase: Radical catalysis involving a [4Fe–4S] cluster and flavin
PNAS 2004 101: 15645-15649; published online before print October 20 2004, 10.1073/pnas.0403952101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cell Biology

Gonzalo E. Torres, Ava L. Sweeney, Jean-Martin Beaulieu, Pullani Shashidharan, and Marc G. Caron

Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated E-torsinA mutant
PNAS 2004 101: 15650-15655; published online before print October 25 2004, 10.1073/pnas.0308088101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Developmental Biology

Marcela Guzman-Ayala, Nadav Ben-Haim, Séverine Beck, and Daniel B. Constam

Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment
PNAS 2004 101: 15656-15660; published online before print October 25 2004, 10.1073/pnas.0405429101 [Abstract] [Full Text] [PDF]  

Ecology

Jon D. Witman, Ron J. Etter, and Franz Smith The relationship between regional and local species diversity in marine benthic communities: A global perspective PNAS 2004 101: 15664-15669; published online before print October 22 2004, 10.1073/pnas.0404300101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Evolution

Ana L. Caicedo, John R. Stinchcombe, Kenneth M. Olsen, Johanna Schmitt, and Michael D. Purugganan

Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait
PNAS 2004 101: 15670-15675; published online before print October 25 2004, 10.1073/pnas.0406232101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Ker-Chau Li, Ching-Ti Liu, Wei Sun, Shinsheng Yuan, and Tianwei Yu

A system for enhancing genome-wide coexpression dynamics study
PNAS 2004 101: 15561-15566; published online before print October 18 2004, 10.1073/pnas.0402962101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chih-Hung Lai, Helen H. Chun, Shareef A. Nahas, Midori Mitui, Kristin M. Gamo, Liutao Du, and Richard A. Gatti

Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons
PNAS 2004 101: 15676-15681; published online before print October 21 2004, 10.1073/pnas.0405155101 [Abstract] [Full Text] [PDF]  

Sharyl L. Wong, Lan V. Zhang, Amy H. Y. Tong, Zhijian Li, Debra S. Goldberg, Oliver D. King, Guillaume Lesage, Marc Vidal, Brenda Andrews, Howard Bussey, Charles Boone, and Frederick P. Roth

Combining biological networks to predict genetic interactions
PNAS 2004 101: 15682-15687; published online before print October 20 2004, 10.1073/pnas.0406614101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yonghong Li, Petra Nowotny, Peter Holmans, Scott Smemo, John S. K. Kauwe, Anthony L. Hinrichs, Kristina Tacey, Lisa Doil, Ryan van Luchene, Veronica Garcia, Charles Rowland, Steve Schrodi, Diane Leong, Goran Gogic, Joanne Chan, Anibal Cravchik, David Ross, Kit Lau, Shirley Kwok, Sheng-Yung Chang, Joe Catanese, John Sninsky, Thomas J. White, John Hardy, John Powell, Simon Lovestone, John C. Morris, Leon Thal, Michael Owen, Julie Williams, Alison Goate, and Andrew Grupe Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family PNAS 2004 101: 15688-15693; published online before print October 26 2004, 10.1073/pnas.0403535101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Mitch McVey, Jeannine R. LaRocque, Melissa D. Adams, and Jeff J. Sekelsky

Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion
PNAS 2004 101: 15694-15699; published online before print October 22 2004, 10.1073/pnas.0406157101 [Abstract] [Full Text] [PDF]  

Gene Yeo, Shawn Hoon, Byrappa Venkatesh, and Christopher B. Burge Variation in sequence and organization of splicing regulatory elements in vertebrate genes PNAS 2004 101: 15700-15705; published online before print October 25 2004, 10.1073/pnas.0404901101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Immunology

Jeffrey A. Yoder, Ronda T. Litman, M. Gail Mueller, Salil Desai, Kimberly P. Dobrinski, Jennifer S. Montgomery, Matthew P. Buzzeo, Tatsuya Ota, Chris T. Amemiya, Nikolaus S. Trede, Sheng Wei, Julie Y. Djeu, Sean Humphray, Kerstin Jekosch, Jose A. Hernandez Prada, David A. Ostrov, and Gary W. Litman

Resolution of the novel immune-type receptor gene cluster in zebrafish
PNAS 2004 101: 15706-15711; published online before print October 20 2004, 10.1073/pnas.0405242101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Stéphanie Eyquem, Karine Chemin, Magali Fasseu, and Jean-Christophe Bories

The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor locus
PNAS 2004 101: 15712-15717; published online before print October 20 2004, 10.1073/pnas.0405546101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Dafang Wan, Yi Gong, Wenxin Qin, Pingping Zhang, Jinjun Li, Lin Wei, Xiaomei Zhou, Hongnian Li, Xiaokun Qiu, Fei Zhong, Liping He, Jian Yu, Genfu Yao, Huiqiu Jiang, Lianfang Qian, Ye Yu, Huiqun Shu, Xianlian Chen, Huili Xu, Minglei Guo, Zhimei Pan, Yan Chen, Chao Ge, Shengli Yang, and Jianren Gu

Large-scale cDNA transfection screening for genes related to cancer development and progression
PNAS 2004 101: 15724-15729; published online before print October 21 2004, 10.1073/pnas.0404089101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Suzanne Stewart, Christopher W. Dawson, Kenzo Takada, John Curnow, Cary A. Moody, John W. Sixbey, and Lawrence S. Young

Epstein–Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-B transcription factor pathway
PNAS 2004 101: 15730-15735; published online before print October 21 2004, 10.1073/pnas.0402135101 [Abstract] [Full Text] [PDF]  

Stefano Fiorucci, John L. Wallace, Andrea Mencarelli, Eleonora Distrutti, Giovanni Rizzo, Silvana Farneti, Antonio Morelli, Jih-Lie Tseng, Babu Suramanyam, William J. Guilford, and John F. Parkinson A -oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction PNAS 2004 101: 15736-15741; published online before print October 25 2004, 10.1073/pnas.0404722101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Microbiology

Scott A. Jeffers, Sonia M. Tusell, Laura Gillim-Ross, Erin M. Hemmila, Jenna E. Achenbach, Gregory J. Babcock, William D. Thomas, Jr., Larissa B. Thackray, Mark D. Young, Robert J. Mason, Donna M. Ambrosino, David E. Wentworth, James C. DeMartini, and Kathryn V. Holmes

CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus
PNAS 2004 101: 15748-15753; published online before print October 20 2004, 10.1073/pnas.0403812101 [Abstract] [Full Text] [PDF]  

Kelley M. VanBuskirk, Elitza Sevova, and John H. Adams

Conserved residues in the Plasmodium vivax Duffy-binding protein ligand domain are critical for erythrocyte receptor recognition
PNAS 2004 101: 15754-15759; published online before print October 21 2004, 10.1073/pnas.0405421101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Oleg A. Igoshin, Albert Goldbeter, Dale Kaiser, and George Oster

A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development
PNAS 2004 101: 15760-15765; published online before print October 20 2004, 10.1073/pnas.0407111101 [Abstract] [Full Text] [PDF]  

Neuroscience

Gay R. Holstein, Richard D. Rabbitt, Giorgio P. Martinelli, Victor L. Friedrich, Jr., Richard D. Boyle, and Stephen M. Highstein

Convergence of excitatory and inhibitory hair cell transmitters shapes vestibular afferent responses
PNAS 2004 101: 15766-15771; published online before print October 25 2004, 10.1073/pnas.0402824101 [Abstract] [Full Text] [PDF]  

Brenda L. K. Coles, Brigitte Angénieux, Tomoyuki Inoue, Katia Del Rio-Tsonis, Jason R. Spence, Roderick R. McInnes, Yvan Arsenijevic, and Derek van der Kooy

Facile isolation and the characterization of human retinal stem cells
PNAS 2004 101: 15772-15777; published online before print October 25 2004, 10.1073/pnas.0401596101 [Abstract] [Full Text] [PDF] [Supporting Information]  

P.-G. de Gennes

Organization of a primitive memory: Olfaction
PNAS 2004 101: 15778-15781; published online before print October 25 2004, 10.1073/pnas.0403868101 [Abstract] [Full Text] [PDF]  

Yuncai Chen, Roland A. Bender, Kristen L. Brunson, Jörn K. Pomper, Dimitri E. Grigoriadis, Wolfgang Wurst, and Tallie Z. Baram

Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus
PNAS 2004 101: 15782-15787; published online before print October 20 2004, 10.1073/pnas.0403975101 [Abstract] [Full Text] [PDF]  

Giorgio Aicardi, Emanuela Argilli, Silvia Cappello, Spartaco Santi, Massimo Riccio, Hans Thoenen, and Marco Canossa

Induction of long-term potentiation and depression is reflected by corresponding changes in secretion of endogenous brain-derived neurotrophic factor
PNAS 2004 101: 15788-15792; published online before print October 25 2004, 10.1073/pnas.0406960101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Physiology

Gennady Cherednichenko, Alanna M. Hurne, James D. Fessenden, Eun Hui Lee, Paul D. Allen, Kurt G. Beam, and Isaac N. Pessah

Conformational activation of Ca²⁺ entry by depolarization of skeletal myotubes
PNAS 2004 101: 15793-15798; published online before print October 25 2004, 10.1073/pnas.0403485101 [Abstract] [Full Text] [PDF]  

Andreas Herrlich, Virginia Leitch, and Landon S. King

Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction
PNAS 2004 101: 15799-15804; published online before print October 21 2004, 10.1073/pnas.0406853101 [Abstract] [Full Text] [PDF]  

Plant Biology

Ping Xu, Stephanie J. Rogers, and Marilyn J. Roossinck

Expression of antiapoptotic genes bcl-xL and ced-9 in tomato enhances tolerance to viral-induced necrosis and abiotic stress
PNAS 2004 101: 15805-15810; published online before print October 25 2004, 10.1073/pnas.0407094101 [Abstract] [Full Text] [PDF]  

Dana Zeidler, Ulrich Zähringer, Isak Gerber, Ian Dubery, Thomas Hartung, Wolf Bors, Peter Hutzler, and Jörg Durner From The Cover: Innate immunity in Arabidopsis thaliana: Lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes PNAS 2004 101: 15811-15816; published online before print October 21 2004, 10.1073/pnas.0404536101 [Abstract] [Full Text] [PDF] [Supporting Table]

Anne Uimari, Mika Kotilainen, Paula Elomaa, Deyue Yu, Victor A. Albert, and Teemu H. Teeri

Integration of reproductive meristem fates by a SEPALLATA-like MADS-box gene
PNAS 2004 101: 15817-15822; published online before print October 25 2004, 10.1073/pnas.0406844101 [Abstract] [Full Text] [PDF] [Supporting Information]  

CORRECTIONS

Correction for Angelov et al., Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis, PNAS 2003 100:4790-4795 [Extract] [Full Text] [PDF]