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COMMENTARIES

B. Leif Hanson

Getting protein solvent structures down cold
PNAS 2004 101: 16393-16394; published online before print November 16 2004, 10.1073/pnas.0407452101 [Extract] [Full Text] [PDF]  
See companion article on page 16405

Martin M. Matzuk

Germ-line immortality
PNAS 2004 101: 16395-16396; published online before print November 16 2004, 10.1073/pnas.0407344101 [Extract] [Full Text] [PDF]  
See companion article on page 16489

Jonathan A. Green

Defining the function of a prolactin gene family member
PNAS 2004 101: 16397-16398; published online before print November 16 2004, 10.1073/pnas.0406934101 [Extract] [Full Text] [PDF]  
See companion article on page 16543

Brian J. Bahnson

An atomic-resolution mechanism of 3-hydroxy-3-methylglutaryl–CoA synthase
PNAS 2004 101: 16399-16400; published online before print November 16 2004, 10.1073/pnas.0407418101 [Extract] [Full Text] [PDF]  
See companion article on page 16442

Thomas L. Schwarz

Synaptotagmin promotes both vesicle fusion and recycling
PNAS 2004 101: 16401-16402; published online before print November 16 2004, 10.1073/pnas.0407390101 [Extract] [Full Text] [PDF]  
See companion article on page 16648

Joseph Bonaventura and Andrew Gow

NO and superoxide: Opposite ends of the seesaw in cardiac contractility
PNAS 2004 101: 16403-16404; published online before print November 16 2004, 10.1073/pnas.0405859101 [Extract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Orly Alter and Gene H. Golub

Integrative analysis of genome-scale data by using pseudoinverse projection predicts novel correlation between DNA replication and RNA transcription
PNAS 2004 101: 16577-16582; published online before print November 15 2004, 10.1073/pnas.0406767101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chemistry

Geophysics

Brian C. O'Neill and Michael Oppenheimer

Climate change impacts are sensitive to the concentration stabilization path
PNAS 2004 101: 16411-16416; published online before print November 15 2004, 10.1073/pnas.0405522101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Mathematics

Ae Ja Yee

Partitions with difference conditions and Alder's conjecture
PNAS 2004 101: 16417-16418; published online before print November 16 2004, 10.1073/pnas.0406971101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Biochemistry

Jaeyul Kwon, Seung-Rock Lee, Kap-Seok Yang, Younghee Ahn, Yeun Ju Kim, Earl R. Stadtman, and Sue Goo Rhee

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
PNAS 2004 101: 16419-16424; published online before print November 8 2004, 10.1073/pnas.0407396101 [Abstract] [Full Text] [PDF]  

Raj Kumar, David E. Volk, Jianquan Li, James C. Lee, David G. Gorenstein, and E. Brad Thompson

TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain
PNAS 2004 101: 16425-16430; published online before print November 15 2004, 10.1073/pnas.0407160101 [Abstract] [Full Text] [PDF]  

Wulf Blankenfeldt, Alexandre P. Kuzin, Tatiana Skarina, Yuriy Korniyenko, Liang Tong, Peter Bayer, Petra Janning, Linda S. Thomashow, and Dmitri V. Mavrodi

Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens
PNAS 2004 101: 16431-16436; published online before print November 15 2004, 10.1073/pnas.0407371101 [Abstract] [Full Text] [PDF] [Supporting Information]  

J. Sohn, K. Kristjánsdóttir, A. Safi, B. Parker, B. Kiburz, and J. Rudolph

Remote hot spots mediate protein substrate recognition for the Cdc25 phosphatase
PNAS 2004 101: 16437-16441; published online before print November 8 2004, 10.1073/pnas.0407663101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Michael J. Theisen, Ila Misra, Dana Saadat, Nino Campobasso, Henry M. Miziorko, and David H. T. Harrison From the Cover: 3-hydroxy-3-methylglutaryl–CoA synthase intermediate complex observed in "real-time" PNAS 2004 101: 16442-16447; published online before print October 21 2004, 10.1073/pnas.0405809101 [Abstract] [Full Text] [PDF]   See Commentary on page 16399

Birte Höcker, Jörg Claren, and Reinhard Sterner

Mimicking enzyme evolution by generating new ()₈-barrels from ()₄-half-barrels
PNAS 2004 101: 16448-16453; published online before print November 11 2004, 10.1073/pnas.0405832101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Feixia Chu, Shu-ou Shan, Demetri T. Moustakas, Frank Alber, Pascal F. Egea, Robert M. Stroud, Peter Walter, and Alma L. Burlingame Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry PNAS 2004 101: 16454-16459; published online before print November 16 2004, 10.1073/pnas.0407456101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Oliver Hartley, Hubert Gaertner, Jill Wilken, Darren Thompson, Richard Fish, Alejandra Ramos, Cristina Pastore, Brigitte Dufour, Fabrice Cerini, Astrid Melotti, Nikolaus Heveker, Laurent Picard, Marc Alizon, Donald Mosier, Stephen Kent, and Robin Offord

Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors
PNAS 2004 101: 16460-16465; published online before print November 15 2004, 10.1073/pnas.0404802101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Biophysics

Jennifer C. Lee, Ralf Langen, Patrick A. Hummel, Harry B. Gray, and Jay R. Winkler

-Synuclein structures from fluorescence energy-transfer kinetics: Implications for the role of the protein in Parkinson's disease
PNAS 2004 101: 16466-16471; published online before print November 9 2004, 10.1073/pnas.0407307101 [Abstract] [Full Text] [PDF]  

E. Perret, A. Leung, H. Feracci, and E. Evans

Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths
PNAS 2004 101: 16472-16477; published online before print November 16 2004, 10.1073/pnas.0402085101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rituparna S. Roy, Isabella L. Karle, S. Raghothama, and P. Balaram

, hybrid peptides: A polypeptide helix with a central segment containing two consecutive -amino acid residues
PNAS 2004 101: 16478-16482; published online before print November 16 2004, 10.1073/pnas.0407557101 [Abstract] [Full Text] [PDF]  

Cell Biology

Mia M. Thi, John M. Tarbell, Sheldon Weinbaum, and David C. Spray

The role of the glycocalyx in reorganization of the actin cytoskeleton under fluid shear stress: A "bumper-car" model
PNAS 2004 101: 16483-16488; published online before print November 15 2004, 10.1073/pnas.0407474101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hiroshi Kubota, Mary R. Avarbock, and Ralph L. Brinster

Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells
PNAS 2004 101: 16489-16494; published online before print November 1 2004, 10.1073/pnas.0407063101 [Abstract] [Full Text] [PDF] [Supporting Information] [Online Correction to Supporting Text]  
See Commentary on page 16395

Kerstin Bystricky, Patrick Heun, Lutz Gehlen, Jörg Langowski, and Susan M. Gasser

Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques
PNAS 2004 101: 16495-16500; published online before print November 15 2004, 10.1073/pnas.0402766101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Kiyoshi Miki, Weidong Qu, Eugenia H. Goulding, William D. Willis, Donna O. Bunch, Lillian F. Strader, Sally D. Perreault, Edward M. Eddy, and Deborah A. O'Brien

Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility
PNAS 2004 101: 16501-16506; published online before print November 16 2004, 10.1073/pnas.0407708101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Enzo Nisoli, Sestina Falcone, Cristina Tonello, Valeria Cozzi, Letizia Palomba, Mara Fiorani, Addolorata Pisconti, Silvia Brunelli, Annalisa Cardile, Maura Francolini, Orazio Cantoni, Michele O. Carruba, Salvador Moncada, and Emilio Clementi

Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals
PNAS 2004 101: 16507-16512; published online before print November 15 2004, 10.1073/pnas.0405432101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lisa M. DiPilato, Xiaodong Cheng, and Jin Zhang

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments
PNAS 2004 101: 16513-16518; published online before print November 15 2004, 10.1073/pnas.0405973101 [Abstract] [Full Text] [PDF]  

Gandikota S. Lakshmikanth, Hans M. Warrick, and James A. Spudich A mitotic kinesin-like protein required for normal karyokinesis, myosin localization to the furrow, and cytokinesis in Dictyostelium PNAS 2004 101: 16519-16524; published online before print November 16 2004, 10.1073/pnas.0407304101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Vijay K. Yechoor, Mary-Elizabeth Patti, Kohjiro Ueki, Palle G. Laustsen, Robert Saccone, Ravi Rauniyar, and C. Ronald Kahn

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice
PNAS 2004 101: 16525-16530; published online before print November 16 2004, 10.1073/pnas.0407574101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tyson V. Sharp, Fernando Munoz, Dimitra Bourboulia, Nadege Presneau, Eva Darai, Hsei-Wei Wang, Mark Cannon, David N. Butcher, Andrew G. Nicholson, George Klein, Stephan Imreh, and Chris Boshoff

LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
PNAS 2004 101: 16531-16536; published online before print November 12 2004, 10.1073/pnas.0407123101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Cristina Aguilera, Ruben Hoya-Arias, Guy Haegeman, Lluís Espinosa, and Anna Bigas

Recruitment of IB to the hes1 promoter is associated with transcriptional repression
PNAS 2004 101: 16537-16542; published online before print November 9 2004, 10.1073/pnas.0404429101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Developmental Biology

Ewa Wandzioch, Åsa Kolterud, Maria Jacobsson, Scott L. Friedman, and Leif Carlsson Lhx2–/– mice develop liver fibrosis PNAS 2004 101: 16549-16554; published online before print November 9 2004, 10.1073/pnas.0404678101 [Abstract] [Full Text] [PDF] [Supporting Text] OPEN ACCESS ARTICLE

Evolution

Liyun Liu, Thérèse Wilson, and J. Woodland Hastings

Molecular evolution of dinoflagellate luciferases, enzymes with three catalytic domains in a single polypeptide
PNAS 2004 101: 16555-16560; published online before print November 15 2004, 10.1073/pnas.0407597101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Robert Bleiweiss

Ultraviolet plumage reflectance distinguishes sibling bird species
PNAS 2004 101: 16561-16564; published online before print November 16 2004, 10.1073/pnas.0406386101 [Abstract] [Full Text] [PDF]  

Else Marie Friis, Kaj Raunsgaard Pedersen, and Peter R. Crane

Araceae from the Early Cretaceous of Portugal: Evidence on the emergence of monocotyledons
PNAS 2004 101: 16565-16570; published online before print November 16 2004, 10.1073/pnas.0407174101 [Abstract] [Full Text] [PDF]  

Catarina Rydin, Kaj Raunsgaard Pedersen, and Else Marie Friis

On the evolutionary history of Ephedra: Cretaceous fossils and extant molecules
PNAS 2004 101: 16571-16576; published online before print November 15 2004, 10.1073/pnas.0407588101 [Abstract] [Full Text] [PDF]  

Genetics

Orly Alter and Gene H. Golub

Integrative analysis of genome-scale data by using pseudoinverse projection predicts novel correlation between DNA replication and RNA transcription
PNAS 2004 101: 16577-16582; published online before print November 15 2004, 10.1073/pnas.0406767101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ahmad M. Khalil, Fatih Z. Boyar, and Daniel J. Driscoll

Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis
PNAS 2004 101: 16583-16587; published online before print November 9 2004, 10.1073/pnas.0406325101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Darryl Y. Nishimura, Melissa Fath, Robert F. Mullins, Charles Searby, Michael Andrews, Roger Davis, Jeaneen L. Andorf, Kirk Mykytyn, Ruth E. Swiderski, Baoli Yang, Rivka Carmi, Edwin M. Stone, and Val C. Sheffield

Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin
PNAS 2004 101: 16588-16593; published online before print November 11 2004, 10.1073/pnas.0405496101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jing Huang, Heng Zhu, Stephen J. Haggarty, David R. Spring, Heejun Hwang, Fulai Jin, Michael Snyder, and Stuart L. Schreiber Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips PNAS 2004 101: 16594-16599; published online before print November 11 2004, 10.1073/pnas.0407117101 [Abstract] [Full Text] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE

Immunology

Juan M. Zapata, Maryla Krajewska, Herbert C. Morse, III, Yongwon Choi, and John C. Reed

TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice
PNAS 2004 101: 16600-16605; published online before print November 15 2004, 10.1073/pnas.0407541101 [Abstract] [Full Text] [PDF] [Supporting Figures] [Online Correction to Supporting Figure Legends]  

Guido Ferlazzo, Maggi Pack, Dolca Thomas, Casper Paludan, Dorothee Schmid, Till Strowig, Gwenola Bougras, William A. Muller, Lorenzo Moretta, and Christian Münz

Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
PNAS 2004 101: 16606-16611; published online before print November 9 2004, 10.1073/pnas.0407522101 [Abstract] [Full Text] [PDF]  

Yuichi Aiba, Masatsugu Oh-hora, Shigeki Kiyonaka, Yayoi Kimura, Atsushi Hijikata, Yasuo Mori, and Tomohiro Kurosaki Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation PNAS 2004 101: 16612-16617; published online before print November 15 2004, 10.1073/pnas.0407468101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Medical Sciences

Yuhao Gao, Wei-Ping Qian, Kimberly Dark, Gianluca Toraldo, Angela S. P. Lin, Robert E. Guldberg, Richard A. Flavell, M. Neale Weitzmann, and Roberto Pacifici

Estrogen prevents bone loss through transforming growth factor signaling in T cells
PNAS 2004 101: 16618-16623; published online before print November 5 2004, 10.1073/pnas.0404888101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Julie Anne Roden, Brandis Belt, Jason Barzel Ross, Thomas Tachibana, Joe Vargas, and Mary Beth Mudgett

A genetic screen to isolate type III effectors translocated into pepper cells during Xanthomonas infection
PNAS 2004 101: 16624-16629; published online before print November 15 2004, 10.1073/pnas.0407383101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Blaise R. Boles, Matthew Thoendel, and Pradeep K. Singh From the Cover: Self-generated diversity produces "insurance effects" in biofilm communities PNAS 2004 101: 16630-16635; published online before print November 16 2004, 10.1073/pnas.0407460101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Melanie J. Barnett, Carol J. Toman, Robert F. Fisher, and Sharon R. Long A dual-genome Symbiosis Chip for coordinate study of signal exchange and development in a prokaryote–host interaction PNAS 2004 101: 16636-16641; published online before print November 12 2004, 10.1073/pnas.0407269101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Dai Wang, Wade Bresnahan, and Thomas Shenk

Human cytomegalovirus encodes a highly specific RANTES decoy receptor
PNAS 2004 101: 16642-16647; published online before print November 9 2004, 10.1073/pnas.0407233101 [Abstract] [Full Text] [PDF]  

Neuroscience

Takeshi Sakurai, Takao Nakagawa, Hidefumi Mitsuno, Hajime Mori, Yasuhisa Endo, Shintarou Tanoue, Yuji Yasukochi, Kazushige Touhara, and Takaaki Nishioka Identification and functional characterization of a sex pheromone receptor in the silkmoth Bombyx mori PNAS 2004 101: 16653-16658; published online before print November 15 2004, 10.1073/pnas.0407596101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Jenny Hsieh, Kinichi Nakashima, Tomoko Kuwabara, Eunice Mejia, and Fred H. Gage Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells PNAS 2004 101: 16659-16664; published online before print November 10 2004, 10.1073/pnas.0407643101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Cynthia Lang, Angel Barco, Leonard Zablow, Eric R. Kandel, Steven A. Siegelbaum, and Stanislav S. Zakharenko

Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation
PNAS 2004 101: 16665-16670; published online before print November 12 2004, 10.1073/pnas.0407581101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Pharmacology

Volker O. Melichar, Delphine Behr-Roussel, Ulrike Zabel, L. Otto Uttenthal, José Rodrigo, Alain Rupin, Tony J. Verbeuren, Arun Kumar H. S., and Harald H. H. W. Schmidt

Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis
PNAS 2004 101: 16671-16676; published online before print November 16 2004, 10.1073/pnas.0405509101 [Abstract] [Full Text] [PDF]  

Jacqueline A. Walisser, Maureen K. Bunger, Edward Glover, and Christopher A. Bradfield

Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development
PNAS 2004 101: 16677-16682; published online before print November 15 2004, 10.1073/pnas.0404379101 [Abstract] [Full Text] [PDF]  

Physiology

Yuefeng Han, Stephen C. Cowin, Mitchell B. Schaffler, and Sheldon Weinbaum

Mechanotransduction and strain amplification in osteocyte cell processes
PNAS 2004 101: 16689-16694; published online before print November 11 2004, 10.1073/pnas.0407429101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Stefan R. Bornstein, Paula Zacharowski, Ralf R. Schumann, Andreas Barthel, Nguyen Tran, Claudia Papewalis, Valeria Rettori, Samuel M. McCann, Klaus Schulze-Osthoff, Werner A. Scherbaum, Jörg Tarnow, and Kai Zacharowski

Impaired adrenal stress response in Toll-like receptor 2-deficient mice
PNAS 2004 101: 16695-16700; published online before print November 16 2004, 10.1073/pnas.0407550101 [Abstract] [Full Text] [PDF]  

Psychology

CORRECTIONS

Correction for Scandura et al., Transforming growth factor -induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation, PNAS 2004 101:15231-15236 [Extract] [Full Text] [PDF]  

Correction for Emami et al., A small molecule inhibitor of -catenin/CREB-binding protein transcription, PNAS 2004 101:12682-12687 [Extract] [Full Text] [PDF]