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COMMENTARIES

Alan G. Sanfey and Jonathan D. Cohen

Is knowing always feeling?
PNAS 2004 101: 16709-16710; published online before print November 22 2004, 10.1073/pnas.0407200101 [Extract] [Full Text] [PDF]  

Steven L. Teitelbaum

Postmenopausal osteoporosis, T cells, and immune dysfunction
PNAS 2004 101: 16711-16712; published online before print November 22 2004, 10.1073/pnas.0407335101 [Extract] [Full Text] [PDF]  

Laurie J. Vitt

Shifting paradigms: Herbivory and body size in lizards
PNAS 2004 101: 16713-16714; published online before print November 22 2004, 10.1073/pnas.0407439101 [Extract] [Full Text] [PDF]  
See companion article on page 16819

PHYSICAL SCIENCES

Applied Mathematics

Lawrence Sirovich and Robert Uglesich

The organization of orientation and spatial frequency in primary visual cortex
PNAS 2004 101: 16941-16946; published online before print November 18 2004, 10.1073/pnas.0407450101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Chemistry

Marcus A. Koch, Lars-Oliver Wittenberg, Sudipta Basu, Duraiswamy A. Jeyaraj, Eleni Gourzoulidou, Kerstin Reinecke, Alex Odermatt, and Herbert Waldmann

Compound library development guided by protein structure similarity clustering and natural product structure
PNAS 2004 101: 16721-16726; published online before print November 17 2004, 10.1073/pnas.0404719101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Susana Conde Ceide, Laurent Trembleau, Gebhard Haberhauer, Laszlo Somogyi, Xiaoying Lu, Tamas Bartfai, and Julius Rebek, Jr.

Synthesis of galmic: A nonpeptide galanin receptor agonist
PNAS 2004 101: 16727-16732; published online before print November 19 2004, 10.1073/pnas.0407543101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Raphaël Plasson, Hugues Bersini, and Auguste Commeyras

Recycling Frank: Spontaneous emergence of homochirality in noncatalytic systems
PNAS 2004 101: 16733-16738; published online before print November 17 2004, 10.1073/pnas.0405293101 [Abstract] [Full Text] [PDF]  

Statistics

Rui Feng, James F. Leckman, and Heping Zhang

Linkage analysis of ordinal traits for pedigree data
PNAS 2004 101: 16739-16744; published online before print November 17 2004, 10.1073/pnas.0404623101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Applied Biological Sciences

Biochemistry

Sen Zhang, Alan Finkelstein, and R. John Collier

Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel
PNAS 2004 101: 16756-16761; published online before print November 17 2004, 10.1073/pnas.0405754101 [Abstract] [Full Text] [PDF]  

Wensheng Wang, Patrick Brandt, Marie L. Rossi, Laura Lindsey-Boltz, Vladimir Podust, Ellen Fanning, Aziz Sancar, and Robert A. Bambara

The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
PNAS 2004 101: 16762-16767; published online before print November 19 2004, 10.1073/pnas.0407686101 [Abstract] [Full Text] [PDF]  

Bogdan Z. Olenyuk, Guo-Jun Zhang, Jeffery M. Klco, Nicholas G. Nickols, William G. Kaelin, Jr., and Peter B. Dervan

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
PNAS 2004 101: 16768-16773; published online before print November 19 2004, 10.1073/pnas.0407617101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Fernando Antunes, Alberto Boveris, and Enrique Cadenas

On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide
PNAS 2004 101: 16774-16779; published online before print November 16 2004, 10.1073/pnas.0405368101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Biophysics

A. S. Fokas, I. M. Gelfand, and A. E. Kister

Prediction of the structural motifs of sandwich proteins
PNAS 2004 101: 16780-16783; published online before print November 18 2004, 10.1073/pnas.0407570101 [Abstract] [Full Text] [PDF]  

S. Tonia Hsieh and George V. Lauder

Running on water: Three-dimensional force generation by basilisk lizards
PNAS 2004 101: 16784-16788; published online before print November 18 2004, 10.1073/pnas.0405736101 [Abstract] [Full Text] [PDF]  

Pascal Auffinger, Franklin A. Hays, Eric Westhof, and P. Shing Ho Halogen bonds in biological molecules PNAS 2004 101: 16789-16794; published online before print November 19 2004, 10.1073/pnas.0407607101 [Abstract] [Full Text] [PDF] [Supporting Table] OPEN ACCESS ARTICLE

Cell Biology

Manrico Morroni, Antonio Giordano, Maria Cristina Zingaretti, Romina Boiani, Rita De Matteis, Barbara B. Kahn, Enzo Nisoli, Cristina Tonello, Catalina Pisoschi, Michele M. Luchetti, Mariella Marelli, and Saverio Cinti

Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
PNAS 2004 101: 16801-16806; published online before print November 19 2004, 10.1073/pnas.0407647101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Anthony O. Gramolini, Thomas Kislinger, Michio Asahi, Wenping Li, Andrew Emili, and David H. MacLennan

Sarcolipin retention in the endoplasmic reticulum depends on its C-terminal RSYQY sequence and its interaction with sarco(endo)plasmic Ca²+-ATPases
PNAS 2004 101: 16807-16812; published online before print November 19 2004, 10.1073/pnas.0407815101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jennifer LeCouter, Constance Zlot, Max Tejada, Franklin Peale, and Napoleone Ferrara Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization PNAS 2004 101: 16813-16818; published online before print November 17 2004, 10.1073/pnas.0407697101 [Abstract] [Full Text] [PDF] OPEN ACCESS ARTICLE

Evolution

Roy J. Britten

Coding sequences of functioning human genes derived entirely from mobile element sequences
PNAS 2004 101: 16825-16830; published online before print November 16 2004, 10.1073/pnas.0406985101 [Abstract] [Full Text] [PDF]  

Genetics

T. Norene O'Sullivan, Xufeng S. Wu, Rivka A. Rachel, Jiang-Dong Huang, Deborah A. Swing, Lydia E. Matesic, John A. Hammer, III, Neal G. Copeland, and Nancy A. Jenkins

dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice
PNAS 2004 101: 16831-16836; published online before print November 18 2004, 10.1073/pnas.0407339101 [Abstract] [Full Text] [PDF]  

Peter J. Sabo, Michael Hawrylycz, James C. Wallace, Richard Humbert, Man Yu, Anthony Shafer, Janelle Kawamoto, Robert Hall, Joshua Mack, Michael O. Dorschner, Michael McArthur, and John A. Stamatoyannopoulos

Discovery of functional noncoding elements by digital analysis of chromatin structure
PNAS 2004 101: 16837-16842; published online before print November 18 2004, 10.1073/pnas.0407387101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sara J. Zanton and B. Franklin Pugh

Changes in genomewide occupancy of core transcriptional regulators during heat stress
PNAS 2004 101: 16843-16848; published online before print November 17 2004, 10.1073/pnas.0404988101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Rim Rzem, Maria Veiga-da-Cunha, Gaëtane Noël, Sophie Goffette, Marie-Cécile Nassogne, Brahim Tabarki, Christina Schöller, Thorsten Marquardt, Miikka Vikkula, and Emile Van Schaftingen

A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria
PNAS 2004 101: 16849-16854; published online before print November 17 2004, 10.1073/pnas.0404840101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lingang Zhang, Simon Kasif, Charles R. Cantor, and Natalia E. Broude

GC/AT-content spikes as genomic punctuation marks
PNAS 2004 101: 16855-16860; published online before print November 17 2004, 10.1073/pnas.0407821101 [Abstract] [Full Text] [PDF]  

Ichiro Hiratani, Amanda Leskovar, and David M. Gilbert

Differentiation-induced replication-timing changes are restricted to AT-rich/long interspersed nuclear element (LINE)-rich isochores
PNAS 2004 101: 16861-16866; published online before print November 19 2004, 10.1073/pnas.0406687101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Zhen-Yu J. Sun, Sun Taek Kim, Il Chul Kim, Amr Fahmy, Ellis L. Reinherz, and Gerhard Wagner

Solution structure of the CD3 ectodomain and comparison with CD3 as a basis for modeling T cell receptor topology and signaling
PNAS 2004 101: 16867-16872; published online before print November 19 2004, 10.1073/pnas.0407576101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Bruno Vanherberghen, Katja Andersson, Leo M. Carlin, Esther N. M. Nolte-`t Hoen, Geoffrey S. Williams, Petter Höglund, and Daniel M. Davis

Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells
PNAS 2004 101: 16873-16878; published online before print November 18 2004, 10.1073/pnas.0406240101 [Abstract] [Full Text] [PDF]  

Emma Andersson Nordahl, Victoria Rydengård, Patrik Nyberg, D. Patric Nitsche, Matthias Mörgelin, Martin Malmsten, Lars Björck, and Artur Schmidtchen

Activation of the complement system generates antibacterial peptides
PNAS 2004 101: 16879-16884; published online before print November 18 2004, 10.1073/pnas.0406678101 [Abstract] [Full Text] [PDF]  

Ananda W. Goldrath, C. John Luckey, Richard Park, Christophe Benoist, and Diane Mathis

The molecular program induced in T cells undergoing homeostatic proliferation
PNAS 2004 101: 16885-16890; published online before print November 17 2004, 10.1073/pnas.0407417101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Medical Sciences

Shuguang Jiang, Luke Walker, Michael Afentoulis, Daniel A. Anderson, Linda Jauron-Mills, Christopher L. Corless, and William H. Fleming

Transplanted human bone marrow contributes to vascular endothelium
PNAS 2004 101: 16891-16896; published online before print November 17 2004, 10.1073/pnas.0404398101 [Abstract] [Full Text] [PDF]  

Manu Kohli, Jian Yu, Craig Seaman, Alberto Bardelli, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer, and Lin Zhang

SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells
PNAS 2004 101: 16897-16902; published online before print November 19 2004, 10.1073/pnas.0403405101 [Abstract] [Full Text] [PDF]  

Heidi Erlandsen, Angel L. Pey, Alejandra Gámez, Belén Pérez, Lourdes R. Desviat, Cristina Aguado, Richard Koch, Sankar Surendran, Stephen Tyring, Reuben Matalon, Charles R. Scriver, Magdalena Ugarte, Aurora Martínez, and Raymond C. Stevens From The Cover: Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations PNAS 2004 101: 16903-16908; published online before print November 19 2004, 10.1073/pnas.0407256101 [Abstract] [Full Text] [PDF] [Supporting Information]

Makoto Yoshimitsu, Takeya Sato, Kesheng Tao, Jagdeep S. Walia, Vanessa I. Rasaiah, Gillian T. Sleep, Gary J. Murray, Armando G. Poeppl, John Underwood, Lori West, Roscoe O. Brady, and Jeffrey A. Medin

Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors
PNAS 2004 101: 16909-16914; published online before print November 18 2004, 10.1073/pnas.0407572101 [Abstract] [Full Text] [PDF]  

Jonathan Dushoff, Joshua B. Plotkin, Simon A. Levin, and David J. D. Earn

Dynamical resonance can account for seasonality of influenza epidemics
PNAS 2004 101: 16915-16916; published online before print November 19 2004, 10.1073/pnas.0407293101 [Abstract] [Full Text] [PDF]  

Microbiology

Paul G. Egland, Robert J. Palmer, Jr., and Paul E. Kolenbrander

Interspecies communication in Streptococcus gordonii–Veillonella atypica biofilms: Signaling in flow conditions requires juxtaposition
PNAS 2004 101: 16917-16922; published online before print November 16 2004, 10.1073/pnas.0407457101 [Abstract] [Full Text] [PDF]  

Anna Bäckström, Carina Lundberg, Dangeruta Kersulyte, Douglas E. Berg, Thomas Borén, and Anna Arnqvist From The Cover: Metastability of Helicobacter pylori bab adhesin genes and dynamics in Lewis b antigen binding PNAS 2004 101: 16923-16928; published online before print November 19 2004, 10.1073/pnas.0404817101 [Abstract] [Full Text] [PDF] [Supporting Information]

Michael Rother and William W. Metcalf Anaerobic growth of Methanosarcina acetivorans C2A on carbon monoxide: An unusual way of life for a methanogenic archaeon PNAS 2004 101: 16929-16934; published online before print November 18 2004, 10.1073/pnas.0407486101 [Abstract] [Full Text] [PDF] [Supporting Table] OPEN ACCESS ARTICLE

Neuroscience

Anthony Leonardo

Experimental test of the birdsong error-correction model
PNAS 2004 101: 16935-16940; published online before print November 22 2004, 10.1073/pnas.0407870101 [Abstract] [Full Text] [PDF]  

Lawrence Sirovich and Robert Uglesich

The organization of orientation and spatial frequency in primary visual cortex
PNAS 2004 101: 16941-16946; published online before print November 18 2004, 10.1073/pnas.0407450101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Lucia M. Vaina and Charles G. Gross

Perceptual deficits in patients with impaired recognition of biological motion after temporal lobe lesions
PNAS 2004 101: 16947-16951; published online before print November 19 2004, 10.1073/pnas.0407668101 [Abstract] [Full Text] [PDF]  

Toshihide Tabata, Kenji Araishi, Kouichi Hashimoto, Yuki Hashimotodani, Herman van der Putten, Bernhard Bettler, and Masanobu Kano Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA PNAS 2004 101: 16952-16957; published online before print November 18 2004, 10.1073/pnas.0405387101 [Abstract] [Full Text] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Pharmacology

David R. Janero, Nathan S. Bryan, Fumito Saijo, Vijay Dhawan, David J. Schwalb, Michael C. Warren, and Martin Feelisch

Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo
PNAS 2004 101: 16958-16963; published online before print November 18 2004, 10.1073/pnas.0406075101 [Abstract] [Full Text] [PDF]  

Haiyan Sun, Sojin Shikano, Qiaojie Xiong, and Min Li

Function recovery after chemobleaching (FRAC): Evidence for activity silent membrane receptors on cell surface
PNAS 2004 101: 16964-16969; published online before print November 17 2004, 10.1073/pnas.0404178101 [Abstract] [Full Text] [PDF]  

Physiology

Andrew Y. Gracey, E. Jane Fraser, Weizhong Li, Yongxiang Fang, Ruth R. Taylor, Jane Rogers, Andrew Brass, and Andrew R. Cossins

Coping with cold: An integrative, multitissue analysis of the transcriptome of a poikilothermic vertebrate
PNAS 2004 101: 16970-16975; published online before print November 18 2004, 10.1073/pnas.0403627101 [Abstract] [Full Text] [PDF] [Supporting Infromation]  

Plant Biology

William A. Laing, Sean Bulley, Michele Wright, Janine Cooney, Dwayne Jensen, Di Barraclough, and Elspeth MacRae

A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis
PNAS 2004 101: 16976-16981; published online before print November 18 2004, 10.1073/pnas.0407453101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

CORRECTIONS

Correction for Lai et al., Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons, PNAS 2004 101:15676-15681 [Extract] [Full Text] [PDF]