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COMMENTARIES

Oscar Fernandez-Capetillo and Andre Nussenzweig

Linking histone deacetylation with the repair of DNA breaks
PNAS 2004 101: 1427-1428; published online before print February 2 2004, 10.1073/pnas.0307342101 [Extract] [Full Text] [PDF]  
See companion article on page 1644

Jerry L. Workman and Susan M. Abmayr

Histone H3 variants and modifications on transcribed genes
PNAS 2004 101: 1429-1430; published online before print February 2 2004, 10.1073/pnas.0308506101 [Extract] [Full Text] [PDF]  
See companion article on page 1525

Thomas H. Söllner

A mutation in the general membrane trafficking machinery and hydrocephaly
PNAS 2004 101: 1431-1432; published online before print February 2 2004, 10.1073/pnas.0308601101 [Extract] [Full Text] [PDF]  
See companion article on page 1748

PHYSICAL SCIENCES

Chemistry

Isabella L. Karle, Haruhiko Yagi, Jane M. Sayer, and Donald M. Jerina

Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N²-deoxyguanosine adduct: Absolute configuration and conformation
PNAS 2004 101: 1433-1438; published online before print February 2 2004, 10.1073/pnas.0307305101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Physics

Matteo Marsili, Fernando Vega-Redondo, and Frantisek Slanina

The rise and fall of a networked society: A formal model
PNAS 2004 101: 1439-1442; published online before print January 26 2004, 10.1073/pnas.0305684101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Virginia J. Vitzthum, Hilde Spielvogel, and Jonathan Thornburg

Interpopulational differences in progesterone levels during conception and implantation in humans
PNAS 2004 101: 1443-1448; published online before print February 2 2004, 10.1073/pnas.0302640101 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Biochemistry

Yves Bourne, Hartmuth C. Kolb, Zoran Radic, K. Barry Sharpless, Palmer Taylor, and Pascale Marchot

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
PNAS 2004 101: 1449-1454; published online before print February 2 2004, 10.1073/pnas.0308206100 [Abstract] [Full Text] [PDF]  

Sung-Jin Kim, Mi-Ran Kim, Diana L. Bedgar, Syed G. A. Moinuddin, Claudia L. Cardenas, Laurence B. Davin, ChulHee Kang, and Norman G. Lewis

Functional reclassification of the putative cinnamyl alcohol dehydrogenase multigene family in Arabidopsis
PNAS 2004 101: 1455-1460; published online before print January 26 2004, 10.1073/pnas.0307987100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jiying Sun, Marjorie Brand, Yukari Zenke, Satoshi Tashiro, Mark Groudine, and Kazuhiko Igarashi

Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network
PNAS 2004 101: 1461-1466; published online before print January 27 2004, 10.1073/pnas.0308083100 [Abstract] [Full Text] [PDF]  

Ricardo Zamel, Alan Poon, Dominic Jaikaran, Angela Andersen, Joan Olive, Diane De Abreu, and Richard A. Collins

Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme
PNAS 2004 101: 1467-1472; published online before print January 30 2004, 10.1073/pnas.0305753101 [Abstract] [Full Text] [PDF]  

Mauricio L. Nogueira, Victoria E. H. Wang, Dean Tantin, Phillip A. Sharp, and Thomas M. Kristie

Herpes simplex virus infections are arrested in Oct-1-deficient cells
PNAS 2004 101: 1473-1478; published online before print January 26 2004, 10.1073/pnas.0307300101 [Abstract] [Full Text] [PDF]  

Ioannis Vakonakis, Jingchuan Sun, Tianfu Wu, Andreas Holzenburg, Susan S. Golden, and Andy C. LiWang

NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: Implications for KaiA–KaiC interaction
PNAS 2004 101: 1479-1484; published online before print January 28 2004, 10.1073/pnas.0305516101 [Abstract] [Full Text] [PDF] [Supporting Information]  

James R. A. Schafer, David A. Fell, Douglas Rothman, and Robert G. Shulman

Protein phosphorylation can regulate metabolite concentrations rather than control flux: The example of glycogen synthase
PNAS 2004 101: 1485-1490; published online before print January 26 2004, 10.1073/pnas.0307299101 [Abstract] [Full Text] [PDF]  

Samara L. Reck-Peterson and Ronald D. Vale

Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae
PNAS 2004 101: 1491-1495; published online before print January 30 2004, 10.1073/pnas.2637011100 [Abstract] [Full Text] [PDF]  

Gilles J. C. Basset, Eoin P. Quinlivan, Stéphane Ravanel, Fabrice Rébeillé, Brian P. Nichols, Kazuo Shinozaki, Motoaki Seki, Lori C. Adams-Phillips, James J. Giovannoni, Jesse F. Gregory, III, and Andrew D. Hanson

Folate synthesis in plants: The p-aminobenzoate branch is initiated by a bifunctional PabA-PabB protein that is targeted to plastids
PNAS 2004 101: 1496-1501; published online before print January 26 2004, 10.1073/pnas.0308331100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Ruby I. MacDonald and Julie A. Cummings

Stabilities of folding of clustered, two-repeat fragments of spectrin reveal a potential hinge in the human erythroid spectrin tetramer
PNAS 2004 101: 1502-1507; published online before print January 27 2004, 10.1073/pnas.0308059100 [Abstract] [Full Text] [PDF]  

Jamila Gupte, Gene Cutler, Jin-Long Chen, and Hui Tian

Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approach
PNAS 2004 101: 1508-1513; published online before print February 2 2004, 10.1073/pnas.0308250100 [Abstract] [Full Text] [PDF]  

Yang-Gyun Kim, Ky Lowenhaupt, Doo-Byoung Oh, Kyeong Kyu Kim, and Alexander Rich

Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: Implications for development of a therapy for poxvirus infection
PNAS 2004 101: 1514-1518; published online before print February 2 2004, 10.1073/pnas.0308260100 [Abstract] [Full Text] [PDF]  

Yael Elbaz, Sonia Steiner-Mordoch, Tsafi Danieli, and Shimon Schuldiner

In vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric state
PNAS 2004 101: 1519-1524; published online before print January 30 2004, 10.1073/pnas.0306533101 [Abstract] [Full Text] [PDF]  

Erin McKittrick, Philip R. Gafken, Kami Ahmad, and Steven Henikoff From The Cover: Histone H3.3 is enriched in covalent modifications associated with active chromatin PNAS 2004 101: 1525-1530; published online before print January 19 2004, 10.1073/pnas.0308092100 [Abstract] [Full Text] [PDF]   See Commentary on page 1429

Biophysics

Mark A. Wilson, Courtney V. St. Amour, Jennifer L. Collins, Dagmar Ringe, and Gregory A. Petsko

The 1.8-Å resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily
PNAS 2004 101: 1531-1536; published online before print January 26 2004, 10.1073/pnas.0308089100 [Abstract] [Full Text] [PDF]  

James Holton and Tom Alber From The Cover: Automated protein crystal structure determination using ELVES PNAS 2004 101: 1537-1542; published online before print January 29 2004, 10.1073/pnas.0306241101 [Abstract] [Full Text] [PDF]

Masanori Arita

The metabolic world of Escherichia coli is not small
PNAS 2004 101: 1543-1547; published online before print February 2 2004, 10.1073/pnas.0306458101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cell Biology

Sonia Terrillon, Claude Barberis, and Michel Bouvier

Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with -arrestin and their trafficking patterns
PNAS 2004 101: 1548-1553; published online before print February 2 2004, 10.1073/pnas.0305322101 [Abstract] [Full Text] [PDF]  

Charles R. Keese, Joachim Wegener, Sarah R. Walker, and Ivar Giaever

Electrical wound-healing assay for cells in vitro
PNAS 2004 101: 1554-1559; published online before print January 27 2004, 10.1073/pnas.0307588100 [Abstract] [Full Text] [PDF]  

Micsunica Platica, Elena Ivan, James F. Holland, Alin Ionescu, Sheryl Chen, John Mandeli, Pamela D. Unger, and Ovidiu Platica

A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells
PNAS 2004 101: 1560-1565; published online before print January 26 2004, 10.1073/pnas.0307829100 [Abstract] [Full Text] [PDF]  

Anders Ström, Johan Hartman, James S. Foster, Silke Kietz, Jay Wimalasena, and Jan-Åke Gustafsson

Estrogen receptor inhibits 17-estradiol-stimulated proliferation of the breast cancer cell line T47D
PNAS 2004 101: 1566-1571; published online before print January 26 2004, 10.1073/pnas.0308319100 [Abstract] [Full Text] [PDF]  

Hisao Moriya and Mark Johnston

Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I
PNAS 2004 101: 1572-1577; published online before print January 30 2004, 10.1073/pnas.0305901101 [Abstract] [Full Text] [PDF]  

Luc de Haro, Géraldine Ferracci, Sandrine Opi, Cécile Iborra, Stéphanie Quetglas, Raymond Miquelis, Christian Lévêque, and Michael Seagar

Ca²⁺/calmodulin transfers the membrane-proximal lipid-binding domain of the v-SNARE synaptobrevin from cis to trans bilayers
PNAS 2004 101: 1578-1583; published online before print February 2 2004, 10.1073/pnas.0303274101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Michelle Piehl, U. Serdar Tulu, Pat Wadsworth, and Lynne Cassimeris

Centrosome maturation: Measurement of microtubule nucleation throughout the cell cycle by using GFP-tagged EB1
PNAS 2004 101: 1584-1588; published online before print January 27 2004, 10.1073/pnas.0308205100 [Abstract] [Full Text] [PDF] [Supporting Movies]  

Laura P. Zanello and Anthony W. Norman

Rapid modulation of osteoblast ion channel responses by 1,25(OH)₂-vitamin D₃ requires the presence of a functional vitamin D nuclear receptor
PNAS 2004 101: 1589-1594; published online before print February 2 2004, 10.1073/pnas.0305802101 [Abstract] [Full Text] [PDF]  

Developmental Biology

David J. Ecker, Paula Stein, Zhe Xu, Carmen J. Williams, Gregory S. Kopf, Warren B. Bilker, Ted Abel, and Richard M. Schultz

Long-term effects of culture of preimplantation mouse embryos on behavior
PNAS 2004 101: 1595-1600; published online before print January 27 2004, 10.1073/pnas.0306846101 [Abstract] [Full Text] [PDF]  

Guenther E. Roth, Mathias S. Gierl, Lars Vollborn, Martin Meise, Ruth Lintermann, and Guenter Korge

The Drosophila gene Start1: A putative cholesterol transporter and key regulator of ecdysteroid synthesis
PNAS 2004 101: 1601-1606; published online before print January 26 2004, 10.1073/pnas.0308212100 [Abstract] [Full Text] [PDF]  

Ecology

Jorge A. Zavala, Aparna G. Patankar, Klaus Gase, and Ian T. Baldwin

Constitutive and inducible trypsin proteinase inhibitor production incurs large fitness costs in Nicotiana attenuata
PNAS 2004 101: 1607-1612; published online before print February 2 2004, 10.1073/pnas.0305096101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Marianne S. V. Douglas, John P. Smol, James M. Savelle, and Jules M. Blais

Prehistoric Inuit whalers affected Arctic freshwater ecosystems
PNAS 2004 101: 1613-1617; published online before print January 26 2004, 10.1073/pnas.0307570100 [Abstract] [Full Text] [PDF]  

Evolution

David B. Mark Welch, Michael P. Cummings, David M. Hillis, and Matthew Meselson From The Cover: Divergent gene copies in the asexual class Bdelloidea (Rotifera) separated before the bdelloid radiation or within bdelloid families PNAS 2004 101: 1622-1625; published online before print January 27 2004, 10.1073/pnas.2136686100 [Abstract] [Full Text] [PDF]

Todd A. Schlenke and David J. Begun

Strong selective sweep associated with a transposon insertion in Drosophila simulans
PNAS 2004 101: 1626-1631; published online before print January 26 2004, 10.1073/pnas.0303793101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Geraldine Butler, Claire Kenny, Ailís Fagan, Cornelia Kurischko, Claude Gaillardin, and Kenneth H. Wolfe

Evolution of the MAT locus and its Ho endonuclease in yeast species
PNAS 2004 101: 1632-1637; published online before print January 26 2004, 10.1073/pnas.0304170101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Klaas Vandepoele, Wouter De Vos, John S. Taylor, Axel Meyer, and Yves Van de Peer

Major events in the genome evolution of vertebrates: Paranome age and size differ considerably between ray-finned fishes and land vertebrates
PNAS 2004 101: 1638-1643; published online before print February 2 2004, 10.1073/pnas.0307968100 [Abstract] [Full Text] [PDF]  

Genetics

Ali Jazayeri, Andrew D. McAinsh, and Stephen P. Jackson

Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair
PNAS 2004 101: 1644-1649; published online before print January 7 2004, 10.1073/pnas.0304797101 [Abstract] [Full Text] [PDF]  
See Commentary on page 1427

Byung Joon Hwang, Hans-Michael Müller, and Paul W. Sternberg

Genome annotation by high-throughput 5' RNA end determination
PNAS 2004 101: 1650-1655; published online before print February 2 2004, 10.1073/pnas.0308384100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Sarit Smolikov, Yuval Mazor, and Anat Krauskopf

ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing
PNAS 2004 101: 1656-1661; published online before print January 26 2004, 10.1073/pnas.0307796100 [Abstract] [Full Text] [PDF]  

Dieter Saur, Jean-Marie Vanderwinden, Barbara Seidler, Roland M. Schmid, Marc-Henri De Laet, and Hans-Dieter Allescher

Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis
PNAS 2004 101: 1662-1667; published online before print February 2 2004, 10.1073/pnas.0305473101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jennifer F. Hughes and John M. Coffin

Human endogenous retrovirus K solo-LTR formation and insertional polymorphisms: Implications for human and viral evolution
PNAS 2004 101: 1668-1672; published online before print February 2 2004, 10.1073/pnas.0307885100 [Abstract] [Full Text] [PDF]  

Takashi Sato, Takahiro Matsumoto, Hirotaka Kawano, Tomoyuki Watanabe, Yoshikatsu Uematsu, Keisuke Sekine, Toru Fukuda, Ken-ichi Aihara, Andrée Krust, Takashi Yamada, Yuko Nakamichi, Yoko Yamamoto, Takashi Nakamura, Kimihiro Yoshimura, Tatsuya Yoshizawa, Daniel Metzger, Pierre Chambon, and Shigeaki Kato

Brain masculinization requires androgen receptor function
PNAS 2004 101: 1673-1678; published online before print January 27 2004, 10.1073/pnas.0305303101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Yifan Liu, Kazufumi Mochizuki, and Martin A. Gorovsky

Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena
PNAS 2004 101: 1679-1684; published online before print January 30 2004, 10.1073/pnas.0305421101 [Abstract] [Full Text] [PDF]  

Matthew McKenzie, Ian A. Trounce, Carolyn A. Cassar, and Carl A. Pinkert

Production of homoplasmic xenomitochondrial mice
PNAS 2004 101: 1685-1690; published online before print January 26 2004, 10.1073/pnas.0303184101 [Abstract] [Full Text] [PDF]  

Ryuzo Yanagimachi, Teruhiko Wakayama, Hidefumi Kishikawa, Gian Maria Fimia, Lucia Monaco, and Paolo Sassone-Corsi

Production of fertile offspring from genetically infertile male mice
PNAS 2004 101: 1691-1695; published online before print February 2 2004, 10.1073/pnas.0307832100 [Abstract] [Full Text] [PDF]  

Immunology

Joanna M. Clark, Alexander E. Annenkov, Manvinder Panesar, Pia Isomäki, Yuti Chernajovsky, and Andrew P. Cope

T cell receptor reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor
PNAS 2004 101: 1696-1701; published online before print January 26 2004, 10.1073/pnas.0308231100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Medical Sciences

Andrea Pichler, Julie L. Prior, and David Piwnica-Worms

Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine
PNAS 2004 101: 1702-1707; published online before print January 30 2004, 10.1073/pnas.0304326101 [Abstract] [Full Text] [PDF]  

Jozsef L. Varga, Andrew V. Schally, Judit E. Horvath, Magdolna Kovacs, Gabor Halmos, Kate Groot, Gabor L. Toller, Zoltan Rekasi, and Marta Zarandi

Increased activity of antagonists of growth hormone-releasing hormone substituted at positions 8, 9, and 10
PNAS 2004 101: 1708-1713; published online before print January 30 2004, 10.1073/pnas.0307288101 [Abstract] [Full Text] [PDF]  

Nikolai N. Khodarev, Michael Beckett, Edwardine Labay, Thomas Darga, Bernard Roizman, and Ralph R. Weichselbaum

STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells
PNAS 2004 101: 1714-1719; published online before print January 30 2004, 10.1073/pnas.0308102100 [Abstract] [Full Text] [PDF]  

Gil-Jin Shim, Loránd Levente Kis, Margaret Warner, and Jan-Åke Gustafsson

Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene
PNAS 2004 101: 1720-1724; published online before print January 26 2004, 10.1073/pnas.0307915100 [Abstract] [Full Text] [PDF]  

Stéphanie A. Backman, Danny Ghazarian, Kelvin So, Otto Sanchez, Kay-Uwe Wagner, Lothar Hennighausen, Akira Suzuki, Ming-Sound Tsao, William B. Chapman, Vuk Stambolic, and Tak W. Mak

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
PNAS 2004 101: 1725-1730; published online before print January 27 2004, 10.1073/pnas.0308217100 [Abstract] [Full Text] [PDF] [Supporting Information]  

François Mallet, Olivier Bouton, Sarah Prudhomme, Valérie Cheynet, Guy Oriol, Bertrand Bonnaud, Gérard Lucotte, Laurent Duret, and Bernard Mandrand

The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology
PNAS 2004 101: 1731-1736; published online before print February 2 2004, 10.1073/pnas.0305763101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Microbiology

Karyn L. Newman, Rodrigo P. P. Almeida, Alexander H. Purcell, and Steven E. Lindow

Cell-cell signaling controls Xylella fastidiosa interactions with both insects and plants
PNAS 2004 101: 1737-1742; published online before print January 30 2004, 10.1073/pnas.0308399100 [Abstract] [Full Text] [PDF]  

Michael D. Robek, Bryan S. Boyd, Stefan F. Wieland, and Francis V. Chisari

Signal transduction pathways that inhibit hepatitis B virus replication
PNAS 2004 101: 1743-1747; published online before print February 2 2004, 10.1073/pnas.0308340100 [Abstract] [Full Text] [PDF]  

Neuroscience

Robert L. Chow, Bela Volgyi, Rachel K. Szilard, David Ng, Colin McKerlie, Stewart A. Bloomfield, David G. Birch, and Roderick R. McInnes

Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1
PNAS 2004 101: 1754-1759; published online before print January 26 2004, 10.1073/pnas.0306520101 [Abstract] [Full Text] [PDF] [Supporting Information]  

R. Miledi, Z. Dueñas, A. Martinez-Torres, C. H. Kawas, and F. Eusebi From The Cover: Microtransplantation of functional receptors and channels from the Alzheimer's brain to frog oocytes PNAS 2004 101: 1760-1763; published online before print January 28 2004, 10.1073/pnas.0308224100 [Abstract] [Full Text] [PDF]

Asaf Presente, Randy S. Boyles, Christine N. Serway, J. Steven de Belle, and Andrew J. Andres

Notch is required for long-term memory in Drosophila
PNAS 2004 101: 1764-1768; published online before print January 29 2004, 10.1073/pnas.0308259100 [Abstract] [Full Text] [PDF]  

Zhongju Xiao and Nobuo Suga

Reorganization of the auditory cortex specialized for echo-delay processing in the mustached bat
PNAS 2004 101: 1769-1774; published online before print January 26 2004, 10.1073/pnas.0307296101 [Abstract] [Full Text] [PDF]  

Plant Biology

Dilusha A. William, Yanhui Su, Michael R. Smith, Meina Lu, Don A. Baldwin, and Doris Wagner

Genomic identification of direct target genes of LEAFY
PNAS 2004 101: 1775-1780; published online before print January 21 2004, 10.1073/pnas.0307842100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Juergen Engelberth, Hans T. Alborn, Eric A. Schmelz, and James H. Tumlinson

Airborne signals prime plants against insect herbivore attack
PNAS 2004 101: 1781-1785; published online before print January 28 2004, 10.1073/pnas.0308037100 [Abstract] [Full Text] [PDF]  

Bethany K. Zolman and Bonnie Bartel

An Arabidopsis indole-3-butyric acid-response mutant defective in PEROXIN6, an apparent ATPase implicated in peroxisomal function
PNAS 2004 101: 1786-1791; published online before print January 26 2004, 10.1073/pnas.0304368101 [Abstract] [Full Text] [PDF]  

CORRECTIONS

Correction for Chen et al., Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy, PNAS 2003 100:15492-15497 [Extract] [Full Text] [PDF]