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Table of Contents

February 17, 2004; 101 (7)  [Index By Author]  [Cover Photo]

FROM THE COVER

Molecular mechanisms of biomineralization

Computational design of soluble membrane proteins

Chemical genetics uncovers myosin Vb function

Inducible and reversible RNA interference

Low acetylcholine consolidates memories during sleep

COMMENTARIES

PHYSICAL SCIENCES
    Applied Mathematics
    Mathematics
    Physics

SOCIAL SCIENCES

BIOLOGICAL SCIENCES
    Biochemistry
    Cell Biology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Plant Biology
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COMMENTARIES

Heinrich Roder
Stepwise helix formation and chain compaction during protein folding
PNAS 2004 101: 1793-1794; published online before print February 9 2004, 10.1073/pnas.0308172101 [Extract] [Full Text] [PDF]  

Ann E. Power
Slow-wave sleep, acetylcholine, and memory consolidation
PNAS 2004 101: 1795-1796; published online before print February 9 2004, 10.1073/pnas.0400237101 [Extract] [Full Text] [PDF]  
See companion article on page 2140

PHYSICAL SCIENCES

Applied Mathematics

E. Cerda, L. Mahadevan, and J. M. Pasini
The elements of draping
PNAS 2004 101: 1806-1810; published online before print February 6 2004, 10.1073/pnas.0307160101 [Abstract] [Full Text] [PDF]  

Mathematics

Christen Brownlee
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Biography of Karl Hess
PNAS 2004 101: 1797-1798; published online before print February 9 2004, 10.1073/pnas.0400379101 [Extract] [Full Text] [PDF]  

Karl Hess and Walter Philipp
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Breakdown of Bell's theorem for certain objective local parameter spaces
PNAS 2004 101: 1799-1805; published online before print January 22 2004, 10.1073/pnas.0307479100 [Abstract] [Full Text] [PDF]  

Physics

S. R. Qiu, A. Wierzbicki, C. A. Orme, A. M. Cody, J. R. Hoyer, G. H. Nancollas, S. Zepeda, and J. J. De Yoreo
From the Cover: Molecular modulation of calcium oxalate crystallization by osteopontin and citrate
PNAS 2004 101: 1811-1815; published online before print February 6 2004, 10.1073/pnas.0307900100 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Biochemistry

Michael D. Feese, Taro Tamada, Yoichi Kato, Yoshitake Maeda, Masako Hirose, Yasuko Matsukura, Hideki Shigematsu, Takanori Muto, Atsushi Matsumoto, Hiroshi Watarai, Kinya Ogami, Tomoyuki Tahara, Takashi Kato, Hiroshi Miyazaki, and Ryota Kuroki
Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
PNAS 2004 101: 1816-1821; published online before print February 9 2004, 10.1073/pnas.0308530100 [Abstract] [Full Text] [PDF]  

David Angeli, James E. Ferrell, Jr., and Eduardo D. Sontag
Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems
PNAS 2004 101: 1822-1827; published online before print February 6 2004, 10.1073/pnas.0308265100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Avram M. Slovic, Hidetoshi Kono, James D. Lear, Jeffery G. Saven, and William F. DeGrado
From the Cover: Computational design of water-soluble analogues of the potassium channel KcsA
PNAS 2004 101: 1828-1833; published online before print February 6 2004, 10.1073/pnas.0306417101 [Abstract] [Full Text] [PDF]  

Nadia Dubé, Alan Cheng, and Michel L. Tremblay
The role of protein tyrosine phosphatase 1B in Ras signaling
PNAS 2004 101: 1834-1839; published online before print February 6 2004, 10.1073/pnas.0304242101 [Abstract] [Full Text] [PDF]  

Chaitanya S. Nirodi, Brenda C. Crews, Kevin R. Kozak, Jason D. Morrow, and Lawrence J. Marnett
The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells
PNAS 2004 101: 1840-1845; published online before print February 6 2004, 10.1073/pnas.0303950101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Michaela Tiemann, Zhihua Han, Raymond Soccio, Jaya Bollineni, Sarah Shefer, Ephraim Sehayek, and Jan L. Breslow
Cholesterol feeding of mice expressing cholesterol 7{alpha}-hydroxylase increases bile acid pool size despite decreased enzyme activity
PNAS 2004 101: 1846-1851; published online before print February 4 2004, 10.1073/pnas.0308426100 [Abstract] [Full Text] [PDF]  

Klas Jönsson, Betty P. Guo, Hans-Jürg Monstein, John J. Mekalanos, and Göran Kronvall
Molecular cloning and characterization of two Helicobacter pylori genes coding for plasminogen-binding proteins
PNAS 2004 101: 1852-1857; published online before print February 9 2004, 10.1073/pnas.0307329101 [Abstract] [Full Text] [PDF]  

Ed Hurt, Ming-juan Luo, Susanne Röther, Robin Reed, and Katja Sträßer
Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex
PNAS 2004 101: 1858-1862; published online before print February 9 2004, 10.1073/pnas.0308663100 [Abstract] [Full Text] [PDF]  

Keisuke Komoda, Satoshi Naito, and Masayuki Ishikawa
Replication of plant RNA virus genomes in a cell-free extract of evacuolated plant protoplasts
PNAS 2004 101: 1863-1867; published online before print February 9 2004, 10.1073/pnas.0307131101 [Abstract] [Full Text] [PDF]  

Cell Biology

D. William Provance, Jr., Christopher R. Gourley, Colleen M. Silan, L. C. Cameron, Kevan M. Shokat, James R. Goldenring, Kavita Shah, Peter G. Gillespie, and John A. Mercer
From the Cover: Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic
PNAS 2004 101: 1868-1873; published online before print February 6 2004, 10.1073/pnas.0305895101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Mien V. Hoang, Mary C. Whelan, and Donald R. Senger
Rho activity critically and selectively regulates endothelial cell organization during angiogenesis
PNAS 2004 101: 1874-1879; published online before print February 9 2004, 10.1073/pnas.0308525100 [Abstract] [Full Text] [PDF]  

I. Zucchi, A. Prinetti, M. Scotti, V. Valsecchi, R. Valaperta, E. Mento, R. Reinbold, P. Vezzoni, S. Sonnino, A. Albertini, and R. Dulbecco
Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro
PNAS 2004 101: 1880-1885; published online before print February 6 2004, 10.1073/pnas.0307292101 [Abstract] [Full Text] [PDF]  

Camilla Persson, Tobias Sjöblom, Arnoud Groen, Kai Kappert, Ulla Engström, Ulf Hellman, Carl-Henrik Heldin, Jeroen den Hertog, and Arne Östman
Preferential oxidation of the second phosphatase domain of receptor-like PTP-{alpha} revealed by an antibody against oxidized protein tyrosine phosphatases
PNAS 2004 101: 1886-1891; published online before print February 4 2004, 10.1073/pnas.0304403101 [Abstract] [Full Text] [PDF]  

Peter C. Scacheri, Orit Rozenblatt-Rosen, Natasha J. Caplen, Tyra G. Wolfsberg, Lowell Umayam, Jeffrey C. Lee, Christina M. Hughes, Kalai Selvi Shanmugam, Arindam Bhattacharjee, Matthew Meyerson, and Francis S. Collins
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells
PNAS 2004 101: 1892-1897; published online before print February 9 2004, 10.1073/pnas.0308698100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Antonio Parrado, Macarena Robledo, M. Rosa Moya-Quiles, Luis A. Marín, Christine Chomienne, Rose Ann Padua, and M. Rocío Álvarez-López
The promyelocytic leukemia zinc finger protein down-regulates apoptosis and expression of the proapoptotic BID protein in lymphocytes
PNAS 2004 101: 1898-1903; published online before print February 9 2004, 10.1073/pnas.0308358100 [Abstract] [Full Text] [PDF]  

Evolution

T. Jonathan Davies, Timothy G. Barraclough, Mark W. Chase, Pamela S. Soltis, Douglas E. Soltis, and Vincent Savolainen
Darwin's abominable mystery: Insights from a supertree of the angiosperms
PNAS 2004 101: 1904-1909; published online before print February 6 2004, 10.1073/pnas.0308127100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jongmin Nam, Joonyul Kim, Shinyoung Lee, Gynheung An, Hong Ma, and Masatoshi Nei
Type I MADS-box genes have experienced faster birth-and-death evolution than type II MADS-box genes in angiosperms
PNAS 2004 101: 1910-1915; published online before print February 5 2004, 10.1073/pnas.0308430100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Genetics

Sorin Istrail, Granger G. Sutton, Liliana Florea, Aaron L. Halpern, Clark M. Mobarry, Ross Lippert, Brian Walenz, Hagit Shatkay, Ian Dew, Jason R. Miller, Michael J. Flanigan, Nathan J. Edwards, Randall Bolanos, Daniel Fasulo, Bjarni V. Halldorsson, Sridhar Hannenhalli, Russell Turner, Shibu Yooseph, Fu Lu, Deborah R. Nusskern, Bixiong Chris Shue, Xiangqun Holly Zheng, Fei Zhong, Arthur L. Delcher, Daniel H. Huson, Saul A. Kravitz, Laurent Mouchard, Knut Reinert, Karin A. Remington, Andrew G. Clark, Michael S. Waterman, Evan E. Eichler, Mark D. Adams, Michael W. Hunkapiller, Eugene W. Myers, and J. Craig Venter
Whole-genome shotgun assembly and comparison of human genome assemblies
PNAS 2004 101: 1916-1921; published online before print February 9 2004, 10.1073/pnas.0307971100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Usha Acharya, Michael Beth Mowen, Kunio Nagashima, and Jairaj K. Acharya
Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors
PNAS 2004 101: 1922-1926; published online before print February 9 2004, 10.1073/pnas.0308693100 [Abstract] [Full Text] [PDF]  

Sunita Gupta, Rebecca A. Schoer, James E. Egan, Gregory J. Hannon, and Vivek Mittal
From the Cover: Inducible, reversible, and stable RNA interference in mammalian cells
PNAS 2004 101: 1927-1932; published online before print February 4 2004, 10.1073/pnas.0306111101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

J. Aquiles Sanchez, Kenneth E. Pierce, John E. Rice, and Lawrence J. Wangh
Linear-After-The-Exponential (LATE)–PCR: An advanced method of asymmetric PCR and its uses in quantitative real-time analysis
PNAS 2004 101: 1933-1938; published online before print February 9 2004, 10.1073/pnas.0305476101 [Abstract] [Full Text] [PDF]  

Danielle M. Friedrichsen, Janet L. Stanford, Sarah D. Isaacs, Marta Janer, Bao-li Chang, Kerry Deutsch, Elizabeth Gillanders, Suzanne Kolb, Katherine E. Wiley, Michael D. Badzioch, S. Lilly Zheng, Patrick C. Walsh, Gail P. Jarvik, Leroy Hood, Jeffrey M. Trent, William B. Isaacs, Elaine A. Ostrander, and Jianfeng Xu
Identification of a prostate cancer susceptibility locus on chromosome 7q11–21 in Jewish families
PNAS 2004 101: 1939-1944; published online before print February 9 2004, 10.1073/pnas.0308336100 [Abstract] [Full Text] [PDF]  

B. H. Collins, E. Rosato, and C. P. Kyriacou
Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C
PNAS 2004 101: 1945-1950; published online before print February 6 2004, 10.1073/pnas.0308240100 [Abstract] [Full Text] [PDF]  

Immunology

Regina M. Kofler, Judith H. Aberle, Stephan W. Aberle, Steven L. Allison, Franz X. Heinz, and Christian W. Mandl
Mimicking live flavivirus immunization with a noninfectious RNA vaccine
PNAS 2004 101: 1951-1956; published online before print February 9 2004, 10.1073/pnas.0307145101 [Abstract] [Full Text] [PDF]  

Sybille M. Eibert, Kyeong-Hee Lee, Rüdiger Pipkorn, Urban Sester, Guido H. Wabnitz, Thomas Giese, Stefan C. Meuer, and Yvonne Samstag
Cofilin peptide homologs interfere with immunological synapse formation and T cell activation
PNAS 2004 101: 1957-1962; published online before print February 3 2004, 10.1073/pnas.0308282100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Philip R. Taylor, Susanne Zamze, Richard J. Stillion, Simon Y. C. Wong, Siamon Gordon, and Luisa Martinez-Pomares
Development of a specific system for targeting protein to metallophilic macrophages
PNAS 2004 101: 1963-1968; published online before print February 5 2004, 10.1073/pnas.0308490100 [Abstract] [Full Text] [PDF]  

Christopher A. Klebanoff, Steven E. Finkelstein, Deborah R. Surman, Michael K. Lichtman, Luca Gattinoni, Marc R. Theoret, Navrose Grewal, Paul J. Spiess, Paul A. Antony, Douglas C. Palmer, Yutaka Tagaya, Steven A. Rosenberg, Thomas A. Waldmann, and Nicholas P. Restifo
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells
PNAS 2004 101: 1969-1974; published online before print February 4 2004, 10.1073/pnas.0307298101 [Abstract] [Full Text] [PDF]  

Satomi Ito, Hitoshi Nagaoka, Reiko Shinkura, Nasim Begum, Masamichi Muramatsu, Mikiyo Nakata, and Tasuku Honjo
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
PNAS 2004 101: 1975-1980; published online before print February 9 2004, 10.1073/pnas.0307335101 [Abstract] [Full Text] [PDF]  

Keiichiro Suzuki, Bob Meek, Yasuko Doi, Masamichi Muramatsu, Tsutomu Chiba, Tasuku Honjo, and Sidonia Fagarasan
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
PNAS 2004 101: 1981-1986; published online before print February 6 2004, 10.1073/pnas.0307317101 [Abstract] [Full Text] [PDF]  

Patricia C. Fulkerson, Nives Zimmermann, Eric B. Brandt, Emily E. Muntel, Matthew P. Doepker, Jessica L. Kavanaugh, Anil Mishra, David P. Witte, Hongwei Zhang, Joshua M. Farber, Ming Yang, Paul S. Foster, and Marc E. Rothenberg
Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-{gamma} (Mig, CXCL9)
PNAS 2004 101: 1987-1992; published online before print February 9 2004, 10.1073/pnas.0308544100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Sung-Yun Pai, Morgan L. Truitt, and I-Cheng Ho
GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
PNAS 2004 101: 1993-1998; published online before print February 9 2004, 10.1073/pnas.0308697100 [Abstract] [Full Text] [PDF]  

Christian Siebold, Bjarke E. Hansen, Jessica R. Wyer, Karl Harlos, Robert E. Esnouf, Arne Svejgaard, John I. Bell, Jack L. Strominger, E. Yvonne Jones, and Lars Fugger
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
PNAS 2004 101: 1999-2004; published online before print February 9 2004, 10.1073/pnas.0308458100 [Abstract] [Full Text] [PDF]  

Victoria E. H. Wang, Dean Tantin, Jianzhu Chen, and Phillip A. Sharp
B cell development and immunoglobulin transcription in Oct-1-deficient mice
PNAS 2004 101: 2005-2010; published online before print February 4 2004, 10.1073/pnas.0307304101 [Abstract] [Full Text] [PDF]  

Kristine Phillips, Nancy Kedersha, Lily Shen, Perry J. Blackshear, and Paul Anderson
Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor {alpha}, cyclooxygenase 2, and inflammatory arthritis
PNAS 2004 101: 2011-2016; published online before print February 9 2004, 10.1073/pnas.0400148101 [Abstract] [Full Text] [PDF]  

Samita Andreansky, Haiyan Liu, Heiko Adler, Ulrich H. Koszinowski, Stacey Efstathiou, and Peter C. Doherty
The limits of protection by "memory" T cells in Ig–/– mice persistently infected with a {gamma}-herpesvirus
PNAS 2004 101: 2017-2022; published online before print February 5 2004, 10.1073/pnas.0307320101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Kazuo Okimoto, Junko Sakurai, Toshiyuki Kobayashi, Hiroaki Mitani, Youko Hirayama, Michael L. Nickerson, Michelle B. Warren, Berton Zbar, Laura S. Schmidt, and Okio Hino
A germ-line insertion in the Birt–Hogg–Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer
PNAS 2004 101: 2023-2027; published online before print February 9 2004, 10.1073/pnas.0308071100 [Abstract] [Full Text] [PDF]  

Ge Jin, Alison Klika, Michelle Callahan, Ben Faga, Joel Danzig, Zhengfan Jiang, Xiaoxia Li, George R. Stark, John Harrington, and Bruce Sherf
Identification of a human NF-{kappa}B-activating protein, TAB3
PNAS 2004 101: 2028-2033; published online before print February 6 2004, 10.1073/pnas.0307314101 [Abstract] [Full Text] [PDF]  

Arthur C. Aufderheide, Wilmar Salo, Michael Madden, John Streitz, Jane Buikstra, Felipe Guhl, Bernardo Arriaza, Colleen Renier, Lorentz E. Wittmers, Jr., Gino Fornaciari, and Marvin Allison
A 9,000-year record of Chagas' disease
PNAS 2004 101: 2034-2039; published online before print February 6 2004, 10.1073/pnas.0307312101 [Abstract] [Full Text] [PDF]  

Nobunao Wakabayashi, Albena T. Dinkova-Kostova, W. David Holtzclaw, Moon-Il Kang, Akira Kobayashi, Masayuki Yamamoto, Thomas W. Kensler, and Paul Talalay
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
PNAS 2004 101: 2040-2045; published online before print February 5 2004, 10.1073/pnas.0307301101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Moon-Il Kang, Akira Kobayashi, Nobunao Wakabayashi, Sang-Geon Kim, and Masayuki Yamamoto
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
PNAS 2004 101: 2046-2051; published online before print February 5 2004, 10.1073/pnas.0308347100 [Abstract] [Full Text] [PDF]  

Toshiki Itoh, Dragana Cado, Ryoichi Kamide, and Stuart Linn
DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen
PNAS 2004 101: 2052-2057; published online before print February 9 2004, 10.1073/pnas.0306551101 [Abstract] [Full Text] [PDF]  

Lelio Orci, William S. Cook, Mariella Ravazzola, May-yun Wang, Byung-Hyun Park, Roberto Montesano, and Roger H. Unger
Rapid transformation of white adipocytes into fat-oxidizing machines
PNAS 2004 101: 2058-2063; published online before print February 9 2004, 10.1073/pnas.0308258100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Kristopher T. Kahle, Ignacio Gimenez, Hatim Hassan, Frederick H. Wilson, Robert D. Wong, Biff Forbush, Peter S. Aronson, and Richard P. Lifton
WNK4 regulates apical and basolateral Cl flux in extrarenal epithelia
PNAS 2004 101: 2064-2069; published online before print February 9 2004, 10.1073/pnas.0308434100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Roy G. Cutler, Jeremiah Kelly, Kristin Storie, Ward A. Pedersen, Anita Tammara, Kimmo Hatanpaa, Juan C. Troncoso, and Mark P. Mattson
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
PNAS 2004 101: 2070-2075; published online before print February 15 2004, 10.1073/pnas.0305799101 [Abstract] [Full Text] [PDF]  

Robert X. Song, Christopher J. Barnes, Zhenguo Zhang, Yongde Bao, Rakesh Kumar, and Richard J. Santen
The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor {alpha} to the plasma membrane
PNAS 2004 101: 2076-2081; published online before print February 5 2004, 10.1073/pnas.0308334100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Bangyan Stiles, Ying Wang, Andreas Stahl, Sara Bassilian, W. Paul Lee, Yoon-Jung Kim, Robert Sherwin, Sherin Devaskar, Ralf Lesche, Mark A. Magnuson, and Hong Wu
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity
PNAS 2004 101: 2082-2087; published online before print February 9 2004, 10.1073/pnas.0308617100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Ralph V. Shohet, Yaz Y. Kisanuki, Xiao-Song Zhao, Zakir Siddiquee, Fatima Franco, and Masashi Yanagisawa
Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy
PNAS 2004 101: 2088-2093; published online before print February 5 2004, 10.1073/pnas.0307159101 [Abstract] [Full Text] [PDF]  

Microbiology

John H. Lee, Su Min P. Yi, Mary E. Anderson, Kristi L. Berger, Michael J. Welsh, Aloysius J. Klingelhutz, and Michelle A. Ozbun
Propagation of infectious human papillomavirus type 16 by using an adenovirus and Cre/LoxP mechanism
PNAS 2004 101: 2094-2099; published online before print February 9 2004, 10.1073/pnas.0308615100 [Abstract] [Full Text] [PDF]  

Mario Forzan, Christoph Wirblich, and Polly Roy
A capsid protein of nonenveloped Bluetongue virus exhibits membrane fusion activity
PNAS 2004 101: 2100-2105; published online before print February 4 2004, 10.1073/pnas.0306448101 [Abstract] [Full Text] [PDF]  

Jay V. Solnick, Lori M. Hansen, Nina R. Salama, Jenni K. Boonjakuakul, and Michael Syvanen
Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques
PNAS 2004 101: 2106-2111; published online before print February 3 2004, 10.1073/pnas.0308573100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sihong Song, Yuanqing Lu, Young-Kook Choi, Yinong Han, Qiushi Tang, Ge Zhao, Kenneth I. Berns, and Terence R. Flotte
DNA-dependent PK inhibits adeno-associated virus DNA integration
PNAS 2004 101: 2112-2116; published online before print February 6 2004, 10.1073/pnas.0307833100 [Abstract] [Full Text] [PDF]  

Claudia A. Studdert and John S. Parkinson
Crosslinking snapshots of bacterial chemoreceptor squads
PNAS 2004 101: 2117-2122; published online before print February 9 2004, 10.1073/pnas.0308622100 [Abstract] [Full Text] [PDF]  

Shah M. Faruque, Nityananda Chowdhury, M. Kamruzzaman, Michelle Dziejman, M. Hasibur Rahman, David A. Sack, G. Balakrish Nair, and John J. Mekalanos
Genetic diversity and virulence potential of environmental Vibrio cholerae population in a cholera-endemic area
PNAS 2004 101: 2123-2128; published online before print February 6 2004, 10.1073/pnas.0308485100 [Abstract] [Full Text] [PDF]  

Stefan F. Wieland, Hans Christian Spangenberg, Robert Thimme, Robert H. Purcell, and Francis V. Chisari
Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees
PNAS 2004 101: 2129-2134; published online before print February 5 2004, 10.1073/pnas.0308478100 [Abstract] [Full Text] [PDF]  

Russell E. Vance, Song Hong, Karsten Gronert, Charles N. Serhan, and John J. Mekalanos
The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase
PNAS 2004 101: 2135-2139; published online before print February 6 2004, 10.1073/pnas.0307308101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Neuroscience

Steffen Gais and Jan Born
From The Cover: Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation
PNAS 2004 101: 2140-2144; published online before print February 6 2004, 10.1073/pnas.0305404101 [Abstract] [Full Text] [PDF] [Supporting Table]  
See Commentary on page 1795

Suk Jin Hong, Huiwu Li, Kevin G. Becker, Valina L. Dawson, and Ted M. Dawson
Identification and analysis of plasticity-induced late-response genes
PNAS 2004 101: 2145-2150; published online before print February 6 2004, 10.1073/pnas.0305170101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Richard Piet, Lydia Vargová, Eva Syková, Dominique A. Poulain, and Stéphane H. R. Oliet
Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk
PNAS 2004 101: 2151-2155; published online before print February 6 2004, 10.1073/pnas.0308408100 [Abstract] [Full Text] [PDF]  

Paul A. Godfrey, Bettina Malnic, and Linda B. Buck
The mouse olfactory receptor gene family
PNAS 2004 101: 2156-2161; published online before print February 9 2004, 10.1073/pnas.0308051100 [Abstract] [Full Text] [PDF] [Supporting Table]  

J. G. Boyd, J. Lee, V. Skihar, R. Doucette, and M. D. Kawaja
LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord
PNAS 2004 101: 2162-2166; published online before print February 5 2004, 10.1073/pnas.0303842101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mark T. Wallace, Ramnarayan Ramachandran, and Barry E. Stein
A revised view of sensory cortical parcellation
PNAS 2004 101: 2167-2172; published online before print February 6 2004, 10.1073/pnas.0305697101 [Abstract] [Full Text] [PDF]  

Eric M. Blalock, James W. Geddes, Kuey Chu Chen, Nada M. Porter, William R. Markesbery, and Philip W. Landfield
Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
PNAS 2004 101: 2173-2178; published online before print February 9 2004, 10.1073/pnas.0308512100 [Abstract] [Full Text] [PDF] [Supporting Tables] [Online Correction to Supporting Table 5]  

Lawrence P. Reagan, Daniel R. Rosell, Gwendolyn E. Wood, Michael Spedding, Carmen Muñoz, Jeffrey Rothstein, and Bruce S. McEwen
Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: Reversal by tianeptine
PNAS 2004 101: 2179-2184; published online before print February 6 2004, 10.1073/pnas.0307294101 [Abstract] [Full Text] [PDF]  

Chenjian Li, Wayne G. Brake, Russell D. Romeo, John C. Dunlop, Marisa Gordon, Rodica Buzescu, Ana Maria Magarinos, Patrick B. Allen, Paul Greengard, Victoria Luine, and Bruce S. McEwen
Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice
PNAS 2004 101: 2185-2190; published online before print February 6 2004, 10.1073/pnas.0307313101 [Abstract] [Full Text] [PDF]  

Karima Chergui, Per Svenningsson, and Paul Greengard
Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
PNAS 2004 101: 2191-2196; published online before print February 9 2004, 10.1073/pnas.0308652100 [Abstract] [Full Text] [PDF]  

Plant Biology

Steffen Reinbothe, Françoise Quigley, John Gray, Andreas Schemenewitz, and Christiane Reinbothe
Identification of plastid envelope proteins required for import of protochlorophyllide oxidoreductase A into the chloroplast of barley
PNAS 2004 101: 2197-2202; published online before print February 9 2004, 10.1073/pnas.0307284101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Steffen Reinbothe, Françoise Quigley, Armin Springer, Andreas Schemenewitz, and Christiane Reinbothe
The outer plastid envelope protein Oep16: Role as precursor translocase in import of protochlorophyllide oxidoreductase A
PNAS 2004 101: 2203-2208; published online before print February 9 2004, 10.1073/pnas.0301962101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Björn Hamberger and Klaus Hahlbrock
The 4-coumarate:CoA ligase gene family in Arabidopsis thaliana comprises one rare, sinapate-activating and three commonly occurring isoenzymes
PNAS 2004 101: 2209-2214; published online before print February 9 2004, 10.1073/pnas.0307307101 [Abstract] [Full Text] [PDF]  

Regla Bustos, Brendan Fahy, Christopher M. Hylton, Robert Seale, N. Miranda Nebane, Anne Edwards, Cathie Martin, and Alison M. Smith
Starch granule initiation is controlled by a heteromultimeric isoamylase in potato tubers
PNAS 2004 101: 2215-2220; published online before print February 6 2004, 10.1073/pnas.0305920101 [Abstract] [Full Text] [PDF] [Supporting Information]  

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