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Table of Contents

February 24, 2004; 101 (8)  [Index By Author]  [Cover Photo]

FROM THE COVER

Mate selection optimizes genetic divergence

Engineering cell-cell communication

Long-range regulation of immunity genes

One gene controls two senses

COMMENTARIES

PHYSICAL SCIENCES
    Applied Physical Sciences

SOCIAL SCIENCES

BIOLOGICAL SCIENCES
    Agricultural Sciences
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Ecology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Physiology
    Plant Biology
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COMMENTARIES

Yoram Gerchman and Ron Weiss
Teaching bacteria a new language
PNAS 2004 101: 2221-2222; published online before print February 17 2004, 10.1073/pnas.0400473101 [Extract] [Full Text] [PDF]  
See companion article on page 2299

PHYSICAL SCIENCES

Applied Physical Sciences

Maki Ohgishi, Kensuke Saji, Kiyotaka Okada, and Tatsuya Sakai
Functional analysis of each blue light receptor, cry1, cry2, phot1, and phot2, by using combinatorial multiple mutants in Arabidopsis
PNAS 2004 101: 2223-2228; published online before print February 17 2004, 10.1073/pnas.0305984101 [Abstract] [Full Text] [PDF] [Supporting Information]  

H. Delanoë-Ayari, R. Al Kurdi, M. Vallade, D. Gulino-Debrac, and D. Riveline
Membrane and acto-myosin tension promote clustering of adhesion proteins
PNAS 2004 101: 2229-2234; published online before print February 11 2004, 10.1073/pnas.0304297101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Agricultural Sciences

T. B. Causey, K. T. Shanmugam, L. P. Yomano, and L. O. Ingram
Engineering Escherichia coli for efficient conversion of glucose to pyruvate
PNAS 2004 101: 2235-2240; published online before print February 12 2004, 10.1073/pnas.0308171100 [Abstract] [Full Text] [PDF]  

Biochemistry

Yan Pan, Thomas Kislinger, Anthony O. Gramolini, Elena Zvaritch, Evangelia G. Kranias, David H. MacLennan, and Andrew Emili
Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics
PNAS 2004 101: 2241-2246; published online before print February 13 2004, 10.1073/pnas.0308174101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Xueyong Zhu, Paul Wentworth, Jr., Anita D. Wentworth, Albert Eschenmoser, Richard A. Lerner, and Ian A. Wilson
Probing the antibody-catalyzed water-oxidation pathway at atomic resolution
PNAS 2004 101: 2247-2252; published online before print February 12 2004, 10.1073/pnas.0307311101 [Abstract] [Full Text] [PDF]  

Huib Ovaa, Benedikt M. Kessler, Ulrika Rolén, Paul J. Galardy, Hidde L. Ploegh, and Maria G. Masucci
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells
PNAS 2004 101: 2253-2258; published online before print February 11 2004, 10.1073/pnas.0308411100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jianyuan Luo, Muyang Li, Yi Tang, Monika Laszkowska, Robert G. Roeder, and Wei Gu
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo
PNAS 2004 101: 2259-2264; published online before print February 12 2004, 10.1073/pnas.0308762101 [Abstract] [Full Text] [PDF]  

Hong Ling, Jane M. Sayer, Brian S. Plosky, Haruhiko Yagi, François Boudsocq, Roger Woodgate, Donald M. Jerina, and Wei Yang
Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase
PNAS 2004 101: 2265-2269; published online before print February 13 2004, 10.1073/pnas.0308332100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Didier Auboeuf, Dennis H. Dowhan, Yun Kyoung Kang, Kimberly Larkin, Jae Woon Lee, Susan M. Berget, and Bert W. O'Malley
Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes
PNAS 2004 101: 2270-2274; published online before print February 17 2004, 10.1073/pnas.0308133100 [Abstract] [Full Text] [PDF]  

Atsunari Tsuchisaka and Athanasios Theologis
Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family
PNAS 2004 101: 2275-2280; published online before print February 17 2004, 10.1073/pnas.0308515101 [Abstract] [Full Text] [PDF] [Supporting Information]  

John Deaton, Jingchuan Sun, Andreas Holzenburg, Douglas K. Struck, Joel Berry, and Ry Young
Functional bacteriorhodopsin is efficiently solubilized and delivered to membranes by the chaperonin GroEL
PNAS 2004 101: 2281-2286; published online before print February 13 2004, 10.1073/pnas.0307759100 [Abstract] [Full Text] [PDF]  

Thomas Scheibel, Jesse Bloom, and Susan L. Lindquist
The elongation of yeast prion fibers involves separable steps of association and conversion
PNAS 2004 101: 2287-2292; published online before print February 17 2004, 10.1073/pnas.0308754101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Biophysics

Mari L. DeMarco and Valerie Daggett
From conversion to aggregation: Protofibril formation of the prion protein
PNAS 2004 101: 2293-2298; published online before print February 13 2004, 10.1073/pnas.0307178101 [Abstract] [Full Text] [PDF]  

Thomas Bulter, Sun-Gu Lee, Wilson WaiChun Wong, Eileen Fung, Michael R. Connor, and James C. Liao
From the Cover: Design of artificial cell–cell communication using gene and metabolic networks
PNAS 2004 101: 2299-2304; published online before print February 6 2004, 10.1073/pnas.0306484101 [Abstract] [Full Text] [PDF] [Supporting Information]  
See Commentary on page 2221

Krzysztof Ginalski, Leszek Rychlewski, David Baker, and Nick V. Grishin
Protein structure prediction for the male-specific region of the human Y chromosome
PNAS 2004 101: 2305-2310; published online before print February 12 2004, 10.1073/pnas.0306306101 [Abstract] [Full Text] [PDF]  

Cell Biology

Ming-Zhi Zhang, Weiyi Mai, Cunxi Li, Sae-youll Cho, Chuanming Hao, Gilbert Moeckel, Runxiang Zhao, Ingyu Kim, Jikui Wang, Huaqi Xiong, Hong Wang, Yasunori Sato, Yizhong Wu, Yasuni Nakanuma, Marusia Lilova, York Pei, Raymond C. Harris, Song Li, Robert J. Coffey, Le Sun, Dianqing Wu, Xing-Zhen Chen, Matthew D. Breyer, Zhizhuang Joe Zhao, James A. McKanna, and Guanqing Wu
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells
PNAS 2004 101: 2311-2316; published online before print February 17 2004, 10.1073/pnas.0400073101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Natalia I. Dmitrieva, Qi Cai, and Maurice B. Burg
Cells adapted to high NaCl have many DNA breaks and impaired DNA repair both in cell culture and in vivo
PNAS 2004 101: 2317-2322; published online before print February 12 2004, 10.1073/pnas.0308463100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Damian B. van Rossum, Randen L. Patterson, Kirill Kiselyov, Darren Boehning, Roxanne K. Barrow, Donald L. Gill, and Solomon H. Snyder
Agonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition
PNAS 2004 101: 2323-2327; published online before print February 17 2004, 10.1073/pnas.0308565100 [Abstract] [Full Text] [PDF]  

Randen L. Patterson, Damian B. van Rossum, Roxanne K. Barrow, and Solomon H. Snyder
RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release
PNAS 2004 101: 2328-2332; published online before print February 17 2004, 10.1073/pnas.0308567100 [Abstract] [Full Text] [PDF]  

Wei Yang, Motomu Shimaoka, JianFeng Chen, and Timothy A. Springer
Activation of integrin {beta}-subunit I-like domains by one-turn C-terminal {alpha}-helix deletions
PNAS 2004 101: 2333-2338; published online before print February 13 2004, 10.1073/pnas.0307291101 [Abstract] [Full Text] [PDF]  

Fajun Yang, Rosalie DeBeaumont, Sharleen Zhou, and Anders M. Näär
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator
PNAS 2004 101: 2339-2344; published online before print February 12 2004, 10.1073/pnas.0308676100 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Caroline Saucier, Hanane Khoury, Ka-Man Venus Lai, Pascal Peschard, David Dankort, Monica A. Naujokas, Jocelyn Holash, George D. Yancopoulos, William J. Muller, Tony Pawson, and Morag Park
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis
PNAS 2004 101: 2345-2350; published online before print February 13 2004, 10.1073/pnas.0308065101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Jingyung Hur, Jessica Chesnes, Kathryn R. Coser, Roseanna S. Lee, Peter Geck, Kurt J. Isselbacher, and Toshi Shioda
The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis
PNAS 2004 101: 2351-2356; published online before print February 12 2004, 10.1073/pnas.0307337101 [Abstract] [Full Text] [PDF]  

Sharon Cantor, Ronny Drapkin, Fan Zhang, Yafang Lin, Juliana Han, Sushmita Pamidi, and David M. Livingston
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations
PNAS 2004 101: 2357-2362; published online before print February 17 2004, 10.1073/pnas.0308717101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Developmental Biology

Kostas Kaloulis, Simona Chera, Monika Hassel, Dominique Gauchat, and Brigitte Galliot
Reactivation of developmental programs: The cAMP-response element-binding protein pathway is involved in hydra head regeneration
PNAS 2004 101: 2363-2368; published online before print February 17 2004, 10.1073/pnas.0306512101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ecology

Alexander M. Koch, Gerrit Kuhn, Pierre Fontanillas, Luca Fumagalli, Jérôme Goudet, and Ian R. Sanders
High genetic variability and low local diversity in a population of arbuscular mycorrhizal fungi
PNAS 2004 101: 2369-2374; published online before print February 11 2004, 10.1073/pnas.0306441101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Guofa Zhou, Noboru Minakawa, Andrew K. Githeko, and Guiyun Yan
Association between climate variability and malaria epidemics in the East African highlands
PNAS 2004 101: 2375-2380; published online before print February 17 2004, 10.1073/pnas.0308714100 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Evolution

Bryan D. Neff
From the Cover: Stabilizing selection on genomic divergence in a wild fish population
PNAS 2004 101: 2381-2385; published online before print February 6 2004, 10.1073/pnas.0307522100 [Abstract] [Full Text] [PDF]  

Genetics

Terje Raudsepp, Eun-Joon Lee, Srinivas R. Kata, Candice Brinkmeyer, James R. Mickelson, Loren C. Skow, James E. Womack, and Bhanu P. Chowdhary
Exceptional conservation of horse–human gene order on X chromosome revealed by high-resolution radiation hybrid mapping
PNAS 2004 101: 2386-2391; published online before print February 17 2004, 10.1073/pnas.0308513100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cristina López-Rodríguez, Christopher L. Antos, John M. Shelton, James A. Richardson, Fangming Lin, Tatiana I. Novobrantseva, Roderick T. Bronson, Peter Igarashi, Anjana Rao, and Eric N. Olson
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression
PNAS 2004 101: 2392-2397; published online before print February 17 2004, 10.1073/pnas.0308703100 [Abstract] [Full Text] [PDF] [Supporting Text]  

Bernard Grisart, Frédéric Farnir, Latifa Karim, Nadine Cambisano, Jong-Joo Kim, Alex Kvasz, Myriam Mni, Patricia Simon, Jean-Marie Frère, Wouter Coppieters, and Michel Georges
Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition
PNAS 2004 101: 2398-2403; published online before print February 12 2004, 10.1073/pnas.0308518100 [Abstract] [Full Text] [PDF] [Supporting Information]  

C. T. Brown and C. G. Callan, Jr.
Evolutionary comparisons suggest many novel cAMP response protein binding sites in Escherichia coli
PNAS 2004 101: 2404-2409; published online before print February 11 2004, 10.1073/pnas.0308628100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Sean Rooney, JoAnn Sekiguchi, Scott Whitlow, Mark Eckersdorff, John P. Manis, Charles Lee, David O. Ferguson, and Frederick W. Alt
Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells
PNAS 2004 101: 2410-2415; published online before print February 12 2004, 10.1073/pnas.0308757101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Kenya Honda, Tatsuaki Mizutani, and Tadatsugu Taniguchi
Negative regulation of IFN-{alpha}/{beta} signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells
PNAS 2004 101: 2416-2421; published online before print February 11 2004, 10.1073/pnas.0307336101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Carrie M. Rosenberger, Richard L. Gallo, and B. Brett Finlay
Interplay between antibacterial effectors: A macrophage antimicrobial peptide impairs intracellular Salmonella replication
PNAS 2004 101: 2422-2427; published online before print February 11 2004, 10.1073/pnas.0304455101 [Abstract] [Full Text] [PDF]  

Christian Skulina, Stephan Schmidt, Klaus Dornmair, Holger Babbe, Axel Roers, Klaus Rajewsky, Hartmut Wekerle, Reinhard Hohlfeld, and Norbert Goebels
Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood
PNAS 2004 101: 2428-2433; published online before print February 17 2004, 10.1073/pnas.0308689100 [Abstract] [Full Text] [PDF]  

Ariel Werman, Rachel Werman-Venkert, Rosalyn White, Jae-Kwon Lee, Batsheva Werman, Yakov Krelin, Elena Voronov, Charles A. Dinarello, and Ron N. Apte
The precursor form of IL-1{alpha} is an intracrine proinflammatory activator of transcription
PNAS 2004 101: 2434-2439; published online before print February 13 2004, 10.1073/pnas.0308705101 [Abstract] [Full Text] [PDF]  

Weisong Zhou, Shaojing Chang, and Thomas M. Aune
From the Cover: Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation
PNAS 2004 101: 2440-2445; published online before print February 13 2004, 10.1073/pnas.0306002101 [Abstract] [Full Text] [PDF]  

David F. Rogan, David J. Cousins, Samantha Santangelo, Panayiotis A. Ioannou, Michael Antoniou, Tak H. Lee, and Dontcho Z. Staynov
Analysis of intergenic transcription in the human IL-4/IL-13 gene cluster
PNAS 2004 101: 2446-2451; published online before print February 11 2004, 10.1073/pnas.0308327100 [Abstract] [Full Text] [PDF]  

Medical Sciences

Laurence J. Egan, Lars Eckmann, Florian R. Greten, Sungwon Chae, Zhi-Wei Li, Gennett M. Myhre, Sylvie Robine, Michael Karin, and Martin F. Kagnoff
I{kappa}B-kinase{beta}-dependent NF-{kappa}B activation provides radioprotection to the intestinal epithelium
PNAS 2004 101: 2452-2457; published online before print February 11 2004, 10.1073/pnas.0306734101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hideto Kojima, Mineko Fujimiya, Kazuhiro Matsumura, Tamio Nakahara, Manami Hara, and Lawrence Chan
Extrapancreatic insulin-producing cells in multiple organs in diabetes
PNAS 2004 101: 2458-2463; published online before print February 17 2004, 10.1073/pnas.0308690100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Tae-Wook Chun, J. Shawn Justement, Christina Sanford, Claire W. Hallahan, Marie A. Planta, Mona Loutfy, Shyam Kottilil, Susan Moir, Colin Kovacs, and Anthony S. Fauci
Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals
PNAS 2004 101: 2464-2469; published online before print February 17 2004, 10.1073/pnas.0307328101 [Abstract] [Full Text] [PDF]  

Florinda Gennuso, Cristina Fernetti, Cataldo Tirolo, Nuccio Testa, Francesca L'Episcopo, Salvo Caniglia, Maria Concetta Morale, J. Donald Ostrow, Lorella Pascolo, Claudio Tiribelli, and Bianca Marchetti
Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)
PNAS 2004 101: 2470-2475; published online before print February 17 2004, 10.1073/pnas.0308452100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ebba Bråkenhielm, Niina Veitonmäki, Renhai Cao, Shinji Kihara, Yuji Matsuzawa, Boris Zhivotovsky, Tohru Funahashi, and Yihai Cao
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
PNAS 2004 101: 2476-2481; published online before print February 17 2004, 10.1073/pnas.0308671100 [Abstract] [Full Text] [PDF]  

Anthony G. Passerini, Denise C. Polacek, Congzhu Shi, Nadeene M. Francesco, Elisabetta Manduchi, Gregory R. Grant, William F. Pritchard, Steven Powell, Gary Y. Chang, Christian J. Stoeckert, Jr., and Peter F. Davies
Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta
PNAS 2004 101: 2482-2487; published online before print February 12 2004, 10.1073/pnas.0305938101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ali G. Gharavi, Tariq Ahmad, Robert D. Wong, Roozbeh Hooshyar, Janene Vaughn, Sarah Oller, Rachelle Z. Frankel, Leslie A. Bruggeman, Vivette D. D'Agati, Paul E. Klotman, and Richard P. Lifton
Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3
PNAS 2004 101: 2488-2493; published online before print February 12 2004, 10.1073/pnas.0308649100 [Abstract] [Full Text] [PDF] [Supporting Information]  

J. Saavedra-Lozano, Y. Cao, J. Callison, R. Sarode, D. Sodora, J. Edgar, J. Hatfield, L. Picker, D. Peterson, O. Ramilo, and E. S. Vitetta
An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory
PNAS 2004 101: 2494-2499; published online before print February 17 2004, 10.1073/pnas.0308381100 [Abstract] [Full Text] [PDF]  

Chen Bing, Yi Bao, John Jenkins, Paul Sanders, Monia Manieri, Saverio Cinti, Michael J. Tisdale, and Paul Trayhurn
Zinc-{alpha}2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia
PNAS 2004 101: 2500-2505; published online before print February 12 2004, 10.1073/pnas.0308647100 [Abstract] [Full Text] [PDF]  

Microbiology

John F. Love, Johanna C. vanderSpek, Vedrana Marin, Luis Guerrero, Timothy M. Logan, and John R. Murphy
Genetic and biophysical studies of diphtheria toxin repressor (DtxR) and the hyperactive mutant DtxR(E175K) support a multistep model of activation
PNAS 2004 101: 2506-2511; published online before print February 12 2004, 10.1073/pnas.0303794101 [Abstract] [Full Text] [PDF] [Supporting Table]  

R. David Pridmore, Bernard Berger, Frank Desiere, David Vilanova, Caroline Barretto, Anne-Cecile Pittet, Marie-Camille Zwahlen, Martine Rouvet, Eric Altermann, Rodolphe Barrangou, Beat Mollet, Annick Mercenier, Todd Klaenhammer, Fabrizio Arigoni, and Mark A. Schell
The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533
PNAS 2004 101: 2512-2517; published online before print February 13 2004, 10.1073/pnas.0307327101 [Abstract] [Full Text] [PDF] [Supporting Information]  

D. C. Ghislaine Mayer, Jian-Bing Mu, Osamu Kaneko, Junhui Duan, Xin-zhuan Su, and Louis H. Miller
Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity
PNAS 2004 101: 2518-2523; published online before print February 11 2004, 10.1073/pnas.0307318101 [Abstract] [Full Text] [PDF]  

Karin L. Meibom, Xibing B. Li, Alex T. Nielsen, Cheng-Yen Wu, Saul Roseman, and Gary K. Schoolnik
The Vibrio cholerae chitin utilization program
PNAS 2004 101: 2524-2529; published online before print February 17 2004, 10.1073/pnas.0308707101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jianxin He, Regina L. Baldini, Eric Déziel, Maude Saucier, Qunhao Zhang, Nicole T. Liberati, Daniel Lee, Jonathan Urbach, Howard M. Goodman, and Laurence G. Rahme
The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes
PNAS 2004 101: 2530-2535; published online before print February 11 2004, 10.1073/pnas.0304622101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jianhua Sui, Wenhui Li, Akikazu Murakami, Azaibi Tamin, Leslie J. Matthews, Swee Kee Wong, Michael J. Moore, Aimee St. Clair Tallarico, Mobolaji Olurinde, Hyeryun Choe, Larry J. Anderson, William J. Bellini, Michael Farzan, and Wayne A. Marasco
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
PNAS 2004 101: 2536-2541; published online before print February 6 2004, 10.1073/pnas.0307140101 [Abstract] [Full Text] [PDF]  

Shiou-Hwei Yeh, Hurng-Yi Wang, Ching-Yi Tsai, Chuan-Liang Kao, Jyh-Yuan Yang, Hwan-Wun Liu, Ih-Jen Su, Shih-Feng Tsai, Ding-Shinn Chen, Pei-Jer Chen, the National Taiwan University SARS Research Team, Ding-Shinn Chen, Yuan-Teh Lee, Che-Ming Teng, Pan-Chyr Yang, Hong-Nerng Ho, Pei-Jer Chen, Ming-Fu Chang, Jin-Town Wang, Shan-Chwen Chang, Chuan-Liang Kao, Wei-Kung Wang, Cheng-Hsiang Hsiao, and Po-Ren Hsueh
Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: Molecular epidemiology and genome evolution
PNAS 2004 101: 2542-2547; published online before print February 11 2004, 10.1073/pnas.0307904100 [Abstract] [Full Text] [PDF]  

Neuroscience

Angela Ho and Thomas C. Südhof
Binding of F-spondin to amyloid-{beta} precursor protein: A candidate amyloid-{beta} precursor protein ligand that modulates amyloid-{beta} precursor protein cleavage
PNAS 2004 101: 2548-2553; published online before print February 17 2004, 10.1073/pnas.0308655100 [Abstract] [Full Text] [PDF]  

Ok-Ho Shin, Anton Maximov, Byung Kook Lim, Josep Rizo, and Thomas C. Südhof
Unexpected Ca2+-binding properties of synaptotagmin 9
PNAS 2004 101: 2554-2559; published online before print February 17 2004, 10.1073/pnas.0308477100 [Abstract] [Full Text] [PDF]  

Iman H. Brivanlou, Jami L. M. Dantzker, Charles F. Stevens, and Edward M. Callaway
Topographic specificity of functional connections from hippocampal CA3 to CA1
PNAS 2004 101: 2560-2565; published online before print February 10 2004, 10.1073/pnas.0308577100 [Abstract] [Full Text] [PDF]  

Xiangmin Xu, Christine E. Collins, Peter M. Kaskan, Ilya Khaytin, Jon H. Kaas, and Vivien A. Casagrande
Optical imaging of visually evoked responses in prosimian primates reveals conserved features of the middle temporal visual area
PNAS 2004 101: 2566-2571; published online before print February 17 2004, 10.1073/pnas.0308745101 [Abstract] [Full Text] [PDF]  

Catherine J. Starr, James A. Kappler, Dylan K. Chan, Richard Kollmar, and A. J. Hudspeth
From The Cover: Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells
PNAS 2004 101: 2572-2577; published online before print February 12 2004, 10.1073/pnas.0308474100 [Abstract] [Full Text] [PDF]  

Ofer Yizhar, Ulf Matti, Rely Melamed, Yamit Hagalili, Dieter Bruns, Jens Rettig, and Uri Ashery
Tomosyn inhibits priming of large dense-core vesicles in a calcium-dependent manner
PNAS 2004 101: 2578-2583; published online before print February 13 2004, 10.1073/pnas.0308700100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Bettina Malnic, Paul A. Godfrey, and Linda B. Buck
The human olfactory receptor gene family
PNAS 2004 101: 2584-2589; published online before print February 13 2004, 10.1073/pnas.0307882100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Iustin V. Tabarean, M. Margarita Behrens, Tamas Bartfai, and Henri Korn
Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition
PNAS 2004 101: 2590-2595; published online before print February 12 2004, 10.1073/pnas.0308718101 [Abstract] [Full Text] [PDF]  

Guojun Chen, Paul Greengard, and Zhen Yan
Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex
PNAS 2004 101: 2596-2600; published online before print February 17 2004, 10.1073/pnas.0308618100 [Abstract] [Full Text] [PDF]  

F. Pataky, R. Pironkova, and A. J. Hudspeth
Radixin is a constituent of stereocilia in hair cells
PNAS 2004 101: 2601-2606; published online before print February 12 2004, 10.1073/pnas.0308620100 [Abstract] [Full Text] [PDF]  

Gunnar Kattenstroth, Evangelia Tantalaki, Thomas C. Südhof, Kurt Gottmann, and Markus Missler
Postsynaptic N-methyl-D-aspartate receptor function requires {alpha}-neurexins
PNAS 2004 101: 2607-2612; published online before print February 13 2004, 10.1073/pnas.0308626100 [Abstract] [Full Text] [PDF]  

Chiung-Wen Chang, Chi-Wei Tsai, Hsiao-Fang Wang, Hsiu-Chao Tsai, Huei-Ying Chen, Ting-Fen Tsai, Hiroshi Takahashi, Hui-Yun Li, Ming-Ji Fann, Chu-Wen Yang, Yoshihide Hayashizaki, Tetsuichiro Saito, and Fu-Chin Liu
Identification of a developmentally regulated striatum-enriched zinc-finger gene, Nolz-1, in the mammalian brain
PNAS 2004 101: 2613-2618; published online before print February 13 2004, 10.1073/pnas.0308645100 [Abstract] [Full Text] [PDF]  

Pharmacology

Kandasam Ravi, Lisa A. Brennan, Snezana Levic, Patrick A. Ross, and Stephen M. Black
S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity
PNAS 2004 101: 2619-2624; published online before print February 17 2004, 10.1073/pnas.0300464101 [Abstract] [Full Text] [PDF]  

Physiology

Hiu-Yee Kwan, Yu Huang, and Xiaoqiang Yao
Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G
PNAS 2004 101: 2625-2630; published online before print February 17 2004, 10.1073/pnas.0304471101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Crystal C. Watkins, Darren Boehning, Adam I. Kaplin, Mahil Rao, Christopher D. Ferris, and Solomon H. Snyder
Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission
PNAS 2004 101: 2631-2635; published online before print February 17 2004, 10.1073/pnas.0308695100 [Abstract] [Full Text] [PDF]  

Christian Winter, Nicole Schulz, Gerhard Giebisch, John P. Geibel, and Carsten A. Wagner
Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone
PNAS 2004 101: 2636-2641; published online before print February 17 2004, 10.1073/pnas.0307321101 [Abstract] [Full Text] [PDF]  

Plant Biology

Yves Balmer, William H. Vensel, Charlene K. Tanaka, William J. Hurkman, Eric Gelhaye, Nicolas Rouhier, Jean-Pierre Jacquot, Wanda Manieri, Peter Schürmann, Michel Droux, and Bob B. Buchanan
Thioredoxin links redox to the regulation of fundamental processes of plant mitochondria
PNAS 2004 101: 2642-2647; published online before print February 17 2004, 10.1073/pnas.0308583101 [Abstract] [Full Text] [PDF]  

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