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COMMENTARIES

Matthew Frerking

When astrocytes signal, kainate receptors respond
PNAS 2004 101: 2649-2650; published online before print February 23 2004, 10.1073/pnas.0400474101 [Extract] [Full Text] [PDF]  
See companion article on page 3172

C. William Birky, Jr.

Bdelloid rotifers revisited
PNAS 2004 101: 2651-2652; published online before print February 23 2004, 10.1073/pnas.0308453101 [Extract] [Full Text] [PDF]  

PERSPECTIVES

Leslea J. Hlusko

Integrating the genotype and phenotype in hominid paleontology
PNAS 2004 101: 2653-2657; published online before print February 15 2004, 10.1073/pnas.0307678101 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Filippo Radicchi, Claudio Castellano, Federico Cecconi, Vittorio Loreto, and Domenico Parisi

Defining and identifying communities in networks
PNAS 2004 101: 2658-2663; published online before print February 23 2004, 10.1073/pnas.0400054101 [Abstract] [Full Text] [PDF]  

Hong Qian and Elliot L. Elson

Fluorescence correlation spectroscopy with high-order and dual-color correlation to probe nonequilibrium steady states
PNAS 2004 101: 2828-2833; published online before print February 17 2004, 10.1073/pnas.0305962101 [Abstract] [Full Text] [PDF]  

Chemistry

Jaeil Bai, X. C. Zeng, Hideki Tanaka, and J. Y. Zeng

Metallic single-walled silicon nanotubes
PNAS 2004 101: 2664-2668; published online before print February 23 2004, 10.1073/pnas.0308467101 [Abstract] [Full Text] [PDF]  

Masamichi Yamanaka, Alexander Shivanyuk, and Julius Rebek, Jr.

Stereochemistry in self-assembled encapsulation complexes: Constellational isomerism
PNAS 2004 101: 2669-2672; published online before print February 23 2004, 10.1073/pnas.0308584101 [Abstract] [Full Text] [PDF]  

Xin Xu and William A. Goddard, III From The Cover: The X3LYP extended density functional for accurate descriptions of nonbond interactions, spin states, and thermochemical properties PNAS 2004 101: 2673-2677; published online before print February 23 2004, 10.1073/pnas.0308730100 [Abstract] [Full Text] [PDF]

Andrew J. Forbes, Steven M. Patrie, Gregory K. Taylor, Yong-Bin Kim, Lihua Jiang, and Neil L. Kelleher

Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS
PNAS 2004 101: 2678-2683; published online before print February 19 2004, 10.1073/pnas.0306575101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ariel Fernández, Ridgway Scott, and R. Stephen Berry

The nonconserved wrapping of conserved protein folds reveals a trend toward increasing connectivity in proteomic networks
PNAS 2004 101: 2823-2827; published online before print February 20 2004, 10.1073/pnas.0308295100 [Abstract] [Full Text] [PDF]  

Mathematics

José Luis Rodrigo

The vortex patch problem for the surface quasi-geostrophic equation
PNAS 2004 101: 2684-2686; published online before print February 17 2004, 10.1073/pnas.0308158101 [Abstract] [Full Text] [PDF]  

Diego Córdoba, Charles Fefferman, and José Luis Rodrigo

Almost sharp fronts for the surface quasi-geostrophic equation
PNAS 2004 101: 2687-2691; published online before print February 20 2004, 10.1073/pnas.0308154101 [Abstract] [Full Text] [PDF]  

SOCIAL SCIENCES

Anthropology

Monica Uddin, Derek E. Wildman, Guozhen Liu, Wenbo Xu, Robert M. Johnson, Patrick R. Hof, Gregory Kapatos, Lawrence I. Grossman, and Morris Goodman

Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles
PNAS 2004 101: 2957-2962; published online before print February 19 2004, 10.1073/pnas.0308725100 [Abstract] [Full Text] [PDF] [Supporting Information] [Online Correction to Supporting Table 5]  

Psychology

Stanley J. Colcombe, Arthur F. Kramer, Kirk I. Erickson, Paige Scalf, Edward McAuley, Neal J. Cohen, Andrew Webb, Gerry J. Jerome, David X. Marquez, and Steriani Elavsky

Cardiovascular fitness, cortical plasticity, and aging
PNAS 2004 101: 3316-3321; published online before print February 20 2004, 10.1073/pnas.0400266101 [Abstract] [Full Text] [PDF]  

BIOLOGICAL SCIENCES

Anthropology

Mordechai E. Kislev, Ehud Weiss, and Anat Hartmann

Impetus for sowing and the beginning of agriculture: Ground collecting of wild cereals
PNAS 2004 101: 2692-2695; published online before print February 19 2004, 10.1073/pnas.0308739101 [Abstract] [Full Text] [PDF]  

Applied Biological Sciences

M. Mahbubur Rahman, Harry L. S. Roberts, Muhammad Sarjan, Sassan Asgari, and Otto Schmidt

Induction and transmission of Bacillus thuringiensis tolerance in the flour moth Ephestia kuehniella
PNAS 2004 101: 2696-2699; published online before print February 20 2004, 10.1073/pnas.0306669101 [Abstract] [Full Text] [PDF]  

Jayong Chung, David J. Haile, and Marianne Wessling-Resnick

Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron efflux
PNAS 2004 101: 2700-2705; published online before print February 18 2004, 10.1073/pnas.0306622101 [Abstract] [Full Text] [PDF]  

Biochemistry

Chih-chin Huang, Miro Venturi, Shahzad Majeed, Michael J. Moore, Sanjay Phogat, Mei-Yun Zhang, Dimiter S. Dimitrov, Wayne A. Hendrickson, James Robinson, Joseph Sodroski, Richard Wyatt, Hyeryun Choe, Michael Farzan, and Peter D. Kwong

Structural basis of tyrosine sulfation and V_H-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
PNAS 2004 101: 2706-2711; published online before print February 23 2004, 10.1073/pnas.0308527100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jan D. Kahmann, Diana A. Wecking, Vera Putter, Ky Lowenhaupt, Yang-Gyun Kim, Peter Schmieder, Hartmut Oschkinat, Alexander Rich, and Markus Schade

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro
PNAS 2004 101: 2712-2717; published online before print February 23 2004, 10.1073/pnas.0308612100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Igor Pechik, Joel Madrazo, Michael W. Mosesson, Irene Hernandez, Gary L. Gilliland, and Leonid Medved

Crystal structure of the complex between thrombin and the central "E" region of fibrin
PNAS 2004 101: 2718-2723; published online before print February 20 2004, 10.1073/pnas.0303440101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Juan Reguera, Aura Carreira, Laura Riolobos, José María Almendral, and Mauricio G. Mateu

Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid
PNAS 2004 101: 2724-2729; published online before print February 23 2004, 10.1073/pnas.0307748101 [Abstract] [Full Text] [PDF]  

Sun Hur, Zachary E. R. Newby, and Thomas C. Bruice

Transition state stabilization by general acid catalysis, water expulsion, and enzyme reorganization in Medicago savita chalcone isomerase
PNAS 2004 101: 2730-2735; published online before print February 20 2004, 10.1073/pnas.0308264100 [Abstract] [Full Text] [PDF] [Supporting Table]  

Peter L. Freddolino, M. Yashar S. Kalani, Nagarajan Vaidehi, Wely B. Floriano, Spencer E. Hall, Rene J. Trabanino, Victor Wai Tak Kam, and William A. Goddard, III

Predicted 3D structure for the human 2 adrenergic receptor and its binding site for agonists and antagonists
PNAS 2004 101: 2736-2741; published online before print February 23 2004, 10.1073/pnas.0308751101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Hiro Nakamura, Hideyuki Kumita, Kiyohiro Imai, Tetsutaro Iizuka, and Yoshitsugu Shiro

ADP reduces the oxygen-binding affinity of a sensory histidine kinase, FixL: The possibility of an enhanced reciprocating kinase reaction
PNAS 2004 101: 2742-2746; published online before print February 17 2004, 10.1073/pnas.0305795101 [Abstract] [Full Text] [PDF]  

Gintaras Deikus, Paul Babitzke, and David H. Bechhofer

Recycling of a regulatory protein by degradation of the RNA to which it binds
PNAS 2004 101: 2747-2751; published online before print February 19 2004, 10.1073/pnas.0307343101 [Abstract] [Full Text] [PDF]  

Philip Ian Padilla, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan

Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors
PNAS 2004 101: 2752-2757; published online before print February 18 2004, 10.1073/pnas.0307345101 [Abstract] [Full Text] [PDF]  

Jonathan A. Bernstein, Pei-Hsun Lin, Stanley N. Cohen, and Sue Lin-Chao

Global analysis of Escherichia coli RNA degradosome function using DNA microarrays
PNAS 2004 101: 2758-2763; published online before print February 23 2004, 10.1073/pnas.0308747101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Zhiquan Zhang, P. T. Ravi Rajagopalan, Tzvia Selzer, Stephen J. Benkovic, and Gordon G. Hammes

Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate
PNAS 2004 101: 2764-2769; published online before print February 20 2004, 10.1073/pnas.0400091101 [Abstract] [Full Text] [PDF]  

Sang Yeol Lee, Hideki Aihara, Tom Ellenberger, and Arthur Landy

Two structural features of integrase that are critical for DNA cleavage by multimers but not by monomers
PNAS 2004 101: 2770-2775; published online before print February 19 2004, 10.1073/pnas.0400135101 [Abstract] [Full Text] [PDF]  

Johannes D. Clausen, Bente Vilsen, David B. McIntosh, Anja P. Einholm, and Jens Peter Andersen

Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca²⁺-ATPase assists in catalysis of E₂/E₂P partial reactions
PNAS 2004 101: 2776-2781; published online before print February 17 2004, 10.1073/pnas.0400122101 [Abstract] [Full Text] [PDF]  

Yaoping Zhang, Edward L. Pohlmann, and Gary P. Roberts

Identification of critical residues in GlnB for its activation of NifA activity in the photosynthetic bacterium Rhodospirillum rubrum
PNAS 2004 101: 2782-2787; published online before print February 17 2004, 10.1073/pnas.0306763101 [Abstract] [Full Text] [PDF]  

Beate Schwer, Rana Sawaya, C. Kiong Ho, and Stewart Shuman

Portability and fidelity of RNA-repair systems
PNAS 2004 101: 2788-2793; published online before print February 18 2004, 10.1073/pnas.0305859101 [Abstract] [Full Text] [PDF]  

George W. Rogers, Jr., Gerald M. Edelman, and Vincent P. Mauro

Differential utilization of upstream AUGs in the -secretase mRNA suggests that a shunting mechanism regulates translation
PNAS 2004 101: 2794-2799; published online before print February 23 2004, 10.1073/pnas.0308576101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Jonas Korlach, Daniel W. Baird, Ahmed A. Heikal, Kyle R. Gee, Gregory R. Hoffman, and Watt W. Webb

Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled -phosphate-linked GTP analogs
PNAS 2004 101: 2800-2805; published online before print February 18 2004, 10.1073/pnas.0308579100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Richard Odegrip, David Coomber, Bill Eldridge, Rosemarie Hederer, Philip A. Kuhlman, Christopher Ullman, Kevin FitzGerald, and Duncan McGregor

CIS display: In vitro selection of peptides from libraries of protein–DNA complexes
PNAS 2004 101: 2806-2810; published online before print February 23 2004, 10.1073/pnas.0400219101 [Abstract] [Full Text] [PDF] [Supporting Data Set]  

Kevin C. McGarry, Valorie T. Ryan, Julia E. Grimwade, and Alan C. Leonard

Two discriminatory binding sites in the Escherichia coli replication origin are required for DNA strand opening by initiator DnaA-ATP
PNAS 2004 101: 2811-2816; published online before print February 20 2004, 10.1073/pnas.0400340101 [Abstract] [Full Text] [PDF]  

Natàlia Reixach, Songpon Deechongkit, Xin Jiang, Jeffery W. Kelly, and Joel N. Buxbaum

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture
PNAS 2004 101: 2817-2822; published online before print February 23 2004, 10.1073/pnas.0400062101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Ariel Fernández, Ridgway Scott, and R. Stephen Berry

The nonconserved wrapping of conserved protein folds reveals a trend toward increasing connectivity in proteomic networks
PNAS 2004 101: 2823-2827; published online before print February 20 2004, 10.1073/pnas.0308295100 [Abstract] [Full Text] [PDF]  

Biophysics

Hong Qian and Elliot L. Elson

Fluorescence correlation spectroscopy with high-order and dual-color correlation to probe nonequilibrium steady states
PNAS 2004 101: 2828-2833; published online before print February 17 2004, 10.1073/pnas.0305962101 [Abstract] [Full Text] [PDF]  

A. M. Fernández-Escamilla, M. S. Cheung, M. C. Vega, M. Wilmanns, J. N. Onuchic, and L. Serrano

Solvation in protein folding analysis: Combination of theoretical and experimental approaches
PNAS 2004 101: 2834-2839; published online before print February 20 2004, 10.1073/pnas.0304180101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Hideaki Koike, Sanae A. Ishijima, Lester Clowney, and Masashi Suzuki

The archaeal feast/famine regulatory protein: Potential roles of its assembly forms for regulating transcription
PNAS 2004 101: 2840-2845; published online before print February 19 2004, 10.1073/pnas.0400109101 [Abstract] [Full Text] [PDF]  

Guido Tiana, Boris E. Shakhnovich, Nikolay V. Dokholyan, and Eugene I. Shakhnovich

Imprint of evolution on protein structures
PNAS 2004 101: 2846-2851; published online before print February 17 2004, 10.1073/pnas.0306638101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Che Ma and Geoffrey Chang

Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli
PNAS 2004 101: 2852-2857; published online before print February 17 2004, 10.1073/pnas.0400137101 [Abstract] [Full Text] [PDF]  

Christina G. Schuette, Kiyotaka Hatsuzawa, Martin Margittai, Alexander Stein, Dietmar Riedel, Petra Küster, Marcelle König, Claus Seidel, and Reinhard Jahn

Determinants of liposome fusion mediated by synaptic SNARE proteins
PNAS 2004 101: 2858-2863; published online before print February 23 2004, 10.1073/pnas.0400044101 [Abstract] [Full Text] [PDF] [Supporting Text]  

Karoly Jakab, Adrian Neagu, Vladimir Mironov, Roger R. Markwald, and Gabor Forgacs

Engineering biological structures of prescribed shape using self-assembling multicellular systems
PNAS 2004 101: 2864-2869; published online before print February 23 2004, 10.1073/pnas.0400164101 [Abstract] [Full Text] [PDF]  

Cell Biology

Erik Bush, Jens Fielitz, Lawrence Melvin, Michael Martinez-Arnold, Timothy A. McKinsey, Ryan Plichta, and Eric N. Olson

A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway
PNAS 2004 101: 2870-2875; published online before print February 19 2004, 10.1073/pnas.0308723101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Cem Elbi, Dawn A. Walker, Guillermo Romero, William P. Sullivan, David O. Toft, Gordon L. Hager, and Donald B. DeFranco

Molecular chaperones function as steroid receptor nuclear mobility factors
PNAS 2004 101: 2876-2881; published online before print February 20 2004, 10.1073/pnas.0400116101 [Abstract] [Full Text] [PDF]  

Feng Cong and Harold Varmus

Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of -catenin
PNAS 2004 101: 2882-2887; published online before print February 23 2004, 10.1073/pnas.0307344101 [Abstract] [Full Text] [PDF]  

Ulas Karaoz, T. M. Murali, Stan Letovsky, Yu Zheng, Chunming Ding, Charles R. Cantor, and Simon Kasif

Whole-genome annotation by using evidence integration in functional-linkage networks
PNAS 2004 101: 2888-2893; published online before print February 23 2004, 10.1073/pnas.0307326101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Vladimir Chubanov, Siegfried Waldegger, Michael Mederos y Schnitzler, Helga Vitzthum, Martin C. Sassen, Hannsjörg W. Seyberth, Martin Konrad, and Thomas Gudermann

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia
PNAS 2004 101: 2894-2899; published online before print February 19 2004, 10.1073/pnas.0305252101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Wendy Prudhomme, George Q. Daley, Peter Zandstra, and Douglas A. Lauffenburger

Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling
PNAS 2004 101: 2900-2905; published online before print February 20 2004, 10.1073/pnas.0308768101 [Abstract] [Full Text] [PDF] [Supporting Data Sets]  

Wei Yang, Motomu Shimaoka, Azucena Salas, Junichi Takagi, and Timothy A. Springer

Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring
PNAS 2004 101: 2906-2911; published online before print February 20 2004, 10.1073/pnas.0307340101 [Abstract] [Full Text] [PDF]  

Rabindra Tirouvanziam, Colin J. Davidson, Joseph S. Lipsick, and Leonard A. Herzenberg

Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes
PNAS 2004 101: 2912-2917; published online before print February 19 2004, 10.1073/pnas.0308734101 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Stephan Güttinger, Petra Mühlhäusser, Roland Koller-Eichhorn, Julius Brennecke, and Ulrike Kutay From The Cover: Transportin2 functions as importin and mediates nuclear import of HuR PNAS 2004 101: 2918-2923; published online before print February 23 2004, 10.1073/pnas.0400342101 [Abstract] [Full Text] [PDF] [Supporting Figures]

Developmental Biology

Catherine L. Prado, Aimee E. Pugh-Bernard, Lynda Elghazi, Beatriz Sosa-Pineda, and Lori Sussel

Ghrelin cells replace insulin-producing cells in two mouse models of pancreas development
PNAS 2004 101: 2924-2929; published online before print February 17 2004, 10.1073/pnas.0308604100 [Abstract] [Full Text] [PDF]  

Taka-aki Matsuoka, Isabella Artner, Eva Henderson, Anna Means, Maike Sander, and Roland Stein

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin
PNAS 2004 101: 2930-2933; published online before print February 18 2004, 10.1073/pnas.0306233101 [Abstract] [Full Text] [PDF] [Supporting Figure]  

Ecology

Richard D. Howard, J. Andrew DeWoody, and William M. Muir

Transgenic male mating advantage provides opportunity for Trojan gene effect in a fish
PNAS 2004 101: 2934-2938; published online before print February 19 2004, 10.1073/pnas.0306285101 [Abstract] [Full Text] [PDF]  

Evolution

Guido Tiana, Boris E. Shakhnovich, Nikolay V. Dokholyan, and Eugene I. Shakhnovich

Imprint of evolution on protein structures
PNAS 2004 101: 2846-2851; published online before print February 17 2004, 10.1073/pnas.0306638101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Xianchun Li, Jerome Baudry, May R. Berenbaum, and Mary A. Schuler

Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450
PNAS 2004 101: 2939-2944; published online before print February 23 2004, 10.1073/pnas.0308691101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Annett Endler, Jürgen Liebig, Thomas Schmitt, Jane E. Parker, Graeme R. Jones, Peter Schreier, and Bert Hölldobler

Surface hydrocarbons of queen eggs regulate worker reproduction in a social insect
PNAS 2004 101: 2945-2950; published online before print March 1 2004, 10.1073/pnas.0308447101 [Abstract] [Full Text] [PDF]  

Arnon Paz, David Mester, Ivan Baca, Eviatar Nevo, and Abraham Korol

Adaptive role of increased frequency of polypurine tracts in mRNA sequences of thermophilic prokaryotes
PNAS 2004 101: 2951-2956; published online before print February 18 2004, 10.1073/pnas.0308594100 [Abstract] [Full Text] [PDF] [Supporting Tables]  

Monica Uddin, Derek E. Wildman, Guozhen Liu, Wenbo Xu, Robert M. Johnson, Patrick R. Hof, Gregory Kapatos, Lawrence I. Grossman, and Morris Goodman

Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles
PNAS 2004 101: 2957-2962; published online before print February 19 2004, 10.1073/pnas.0308725100 [Abstract] [Full Text] [PDF] [Supporting Information] [Online Correction to Supporting Table 5]  

Genetics

Zhipei Liu, Manfred Hergenhahn, Heinz H. Schmeiser, Gerald N. Wogan, Amanda Hong, and Monica Hollstein

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene
PNAS 2004 101: 2963-2968; published online before print February 19 2004, 10.1073/pnas.0308607101 [Abstract] [Full Text] [PDF]  

Damian R. Page, Claudia Köhler, José A. da Costa-Nunes, Célia Baroux, James M. Moore, and Ueli Grossniklaus

Intrachromosomal excision of a hybrid Ds element induces large genomic deletions in Arabidopsis
PNAS 2004 101: 2969-2974; published online before print February 23 2004, 10.1073/pnas.0400089101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Taisuke Hosaka, William H. Biggs, III, David Tieu, Antonia D. Boyer, Nissi M. Varki, Webster K. Cavenee, and Karen C. Arden

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
PNAS 2004 101: 2975-2980; published online before print February 20 2004, 10.1073/pnas.0400093101 [Abstract] [Full Text] [PDF]  

Amos Tanay, Roded Sharan, Martin Kupiec, and Ron Shamir

Revealing modularity and organization in the yeast molecular network by integrated analysis of highly heterogeneous genomewide data
PNAS 2004 101: 2981-2986; published online before print February 18 2004, 10.1073/pnas.0308661100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Isabel López de Silanes, Ming Zhan, Ashish Lal, Xiaoling Yang, and Myriam Gorospe

Identification of a target RNA motif for RNA-binding protein HuR
PNAS 2004 101: 2987-2992; published online before print February 23 2004, 10.1073/pnas.0306453101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Gloria Esposito, Bijay S. Jaiswal, Fang Xie, Magda A. M. Krajnc-Franken, Tamara J. A. A. Robben, Ankie M. Strik, Cor Kuil, Ria L. A. Philipsen, Marcel van Duin, Marco Conti, and Jan A. Gossen

Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect
PNAS 2004 101: 2993-2998; published online before print February 19 2004, 10.1073/pnas.0400050101 [Abstract] [Full Text] [PDF] [Supporting Movies]  

George Adrian Calin, Cinzia Sevignani, Calin Dan Dumitru, Terry Hyslop, Evan Noch, Sai Yendamuri, Masayoshi Shimizu, Sashi Rattan, Florencia Bullrich, Massimo Negrini, and Carlo M. Croce

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
PNAS 2004 101: 2999-3004; published online before print February 18 2004, 10.1073/pnas.0307323101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Immunology

Wayne W. Hancock, Frank M. Szaba, Kiera N. Berggren, Michelle A. Parent, Isis K. Mullarky, John Pearl, Andrea M. Cooper, Kenneth H. Ely, David L. Woodland, In-Jeong Kim, Marcia A. Blackman, Lawrence L. Johnson, and Stephen T. Smiley

Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN-inducible fibrinogen-like protein 2
PNAS 2004 101: 3005-3010; published online before print February 19 2004, 10.1073/pnas.0308369101 [Abstract] [Full Text] [PDF]  

Elena Sandalova, Cheng-Hong Wei, Maria G. Masucci, and Victor Levitsky

Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering
PNAS 2004 101: 3011-3016; published online before print February 17 2004, 10.1073/pnas.0400005101 [Abstract] [Full Text] [PDF]  

Klara Tenner-Racz, Christiane Stahl Hennig, Klaus Überla, Heribert Stoiber, Ralf Ignatius, Jonathan Heeney, Ralph M. Steinman, and Paul Racz

Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus
PNAS 2004 101: 3017-3022; published online before print February 17 2004, 10.1073/pnas.0308677101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Binfeng Lu, Panayiotis Zagouras, James E. Fischer, Junfeng Lu, Baiyong Li, and Richard A. Flavell

Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation
PNAS 2004 101: 3023-3028; published online before print February 20 2004, 10.1073/pnas.0307743100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Mousa Komai-Koma, Louise Jones, Graham S. Ogg, Damo Xu, and Foo Y. Liew

TLR2 is expressed on activated T cells as a costimulatory receptor
PNAS 2004 101: 3029-3034; published online before print February 23 2004, 10.1073/pnas.0400171101 [Abstract] [Full Text] [PDF]  

Lianjun Shen and Kenneth L. Rock

Cellular protein is the source of cross-priming antigen in vivo
PNAS 2004 101: 3035-3040; published online before print February 20 2004, 10.1073/pnas.0308345101 [Abstract] [Full Text] [PDF]  

Qing Ge, Ailin Bai, Brendan Jones, Herman N. Eisen, and Jianzhu Chen

Competition for self-peptide-MHC complexes and cytokines between naïve and memory CD8⁺ T cells expressing the same or different T cell receptors
PNAS 2004 101: 3041-3046; published online before print February 19 2004, 10.1073/pnas.0307339101 [Abstract] [Full Text] [PDF]  

Medical Sciences

Thomas C. Beller, Daniel S. Friend, Akiko Maekawa, Bing K. Lam, K. Frank Austen, and Yoshihide Kanaoka

Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis
PNAS 2004 101: 3047-3052; published online before print February 17 2004, 10.1073/pnas.0400235101 [Abstract] [Full Text] [PDF]  

Antonis Voutetakis, Marc R. Kok, Changyu Zheng, Ioannis Bossis, Jianghua Wang, Ana P. Cotrim, Natanya Marracino, Corinne M. Goldsmith, John A. Chiorini, Y. Peng Loh, Lynnette K. Nieman, and Bruce J. Baum

Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics
PNAS 2004 101: 3053-3058; published online before print February 20 2004, 10.1073/pnas.0400136101 [Abstract] [Full Text] [PDF]  

Tapan K. Bera, Sudipto Das, Hiroshi Maeda, Richard Beers, Curt D. Wolfgang, Vasantha Kumar, Yoonsoo Hahn, Byungkook Lee, and Ira Pastan

NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate
PNAS 2004 101: 3059-3064; published online before print February 23 2004, 10.1073/pnas.0308746101 [Abstract] [Full Text] [PDF]  

Cristina Casalone, Gianluigi Zanusso, Pierluigi Acutis, Sergio Ferrari, Lorenzo Capucci, Fabrizio Tagliavini, Salvatore Monaco, and Maria Caramelli

Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob disease
PNAS 2004 101: 3065-3070; published online before print February 17 2004, 10.1073/pnas.0305777101 [Abstract] [Full Text] [PDF]  

Yang D. Teng, Howard Choi, Renna C. Onario, Shan Zhu, Federico C. Desilets, Shoumin Lan, Eric J. Woodard, Evan Y. Snyder, Marc E. Eichler, and Robert M. Friedlander

Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
PNAS 2004 101: 3071-3076; published online before print February 23 2004, 10.1073/pnas.0306239101 [Abstract] [Full Text] [PDF]  

Natalay Kouprina, Michael Mullokandov, Igor B. Rogozin, N. Keith Collins, Greg Solomon, John Otstot, John I. Risinger, Eugene V. Koonin, J. Carl Barrett, and Vladimir Larionov

The SPANX gene family of cancer/testis-specific antigens: Rapid evolution and amplification in African great apes and hominids
PNAS 2004 101: 3077-3082; published online before print February 18 2004, 10.1073/pnas.0308532100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jonathan H. LeBowitz, Jeffrey H. Grubb, John A. Maga, Deborah H. Schmiel, Carole Vogler, and William S. Sly

Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice
PNAS 2004 101: 3083-3088; published online before print February 19 2004, 10.1073/pnas.0308728100 [Abstract] [Full Text] [PDF]  

Tian-Li Wang, Luis A. Diaz, Jr., Katharine Romans, Alberto Bardelli, Saurabh Saha, Gennaro Galizia, Michael Choti, Ross Donehower, Giovanni Parmigiani, Ie-Ming Shih, Christine Iacobuzio-Donahue, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer, and Victor E. Velculescu

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients
PNAS 2004 101: 3089-3094; published online before print February 17 2004, 10.1073/pnas.0308716101 [Abstract] [Full Text] [PDF]  

Subhash C. Sinha, Lian-Sheng Li, Gregory P. Miller, Shantanu Dutta, Christoph Rader, and Richard A. Lerner

Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab
PNAS 2004 101: 3095-3099; published online before print February 23 2004, 10.1073/pnas.0307319101 [Abstract] [Full Text] [PDF] [Supporting Schemes]  

Markus Schubert, Dinesh Gautam, David Surjo, Kojihiko Ueki, Stephanie Baudler, Dominic Schubert, Tatsuya Kondo, Jens Alber, Norbert Galldiks, Eckehardt Küstermann, Saskia Arndt, Andreas H. Jacobs, Wilhelm Krone, C. Ronald Kahn, and Jens C. Brüning

Role for neuronal insulin resistance in neurodegenerative diseases
PNAS 2004 101: 3100-3105; published online before print February 23 2004, 10.1073/pnas.0308724101 [Abstract] [Full Text] [PDF]  

Kathleen M. I. Caron, Leighton R. James, Hyung-Suk Kim, Josh Knowles, Rick Uhlir, Lan Mao, John R. Hagaman, Wayne Cascio, Howard Rockman, and Oliver Smithies

Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
PNAS 2004 101: 3106-3111; published online before print February 20 2004, 10.1073/pnas.0307333101 [Abstract] [Full Text] [PDF] [Supporting Table]  

Jianchao Xu, Peili Wang, Yanyan Li, Guoyong Li, Leonard K. Kaczmarek, Yanling Wu, Pandelakis A. Koni, Richard A. Flavell, and Gary V. Desir

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity
PNAS 2004 101: 3112-3117; published online before print February 23 2004, 10.1073/pnas.0308450100 [Abstract] [Full Text] [PDF]  

Desheng Lu, Yandong Zhao, Rommel Tawatao, Howard B. Cottam, Malini Sen, Lorenzo M. Leoni, Thomas J. Kipps, Maripat Corr, and Dennis A. Carson

Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
PNAS 2004 101: 3118-3123; published online before print February 18 2004, 10.1073/pnas.0308648100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jerome Schaack, Michael L. Bennett, Jeff D. Colbert, Andres Vazquez Torres, Gerald H. Clayton, David Ornelles, and John Moorhead

E1A and E1B proteins inhibit inflammation induced by adenovirus
PNAS 2004 101: 3124-3129; published online before print February 19 2004, 10.1073/pnas.0303709101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

M. Golam Mohi, Christina Boulton, Ting-Lei Gu, David W. Sternberg, Donna Neuberg, James D. Griffin, D. Gary Gilliland, and Benjamin G. Neel

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs
PNAS 2004 101: 3130-3135; published online before print February 19 2004, 10.1073/pnas.0400063101 [Abstract] [Full Text] [PDF] [Supporting Figures]  

Anna Hansson, Nicole Hance, Eric Dufour, Anja Rantanen, Kjell Hultenby, David A. Clayton, Rolf Wibom, and Nils-Göran Larsson

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts
PNAS 2004 101: 3136-3141; published online before print February 20 2004, 10.1073/pnas.0308710100 [Abstract] [Full Text] [PDF]  

Microbiology

Dorothee Grimm, Kit Tilly, Rebecca Byram, Philip E. Stewart, Jonathan G. Krum, Dawn M. Bueschel, Tom G. Schwan, Paul F. Policastro, Abdallah F. Elias, and Patricia A. Rosa

Outer-surface protein C of the Lyme disease spirochete: A protein induced in ticks for infection of mammals
PNAS 2004 101: 3142-3147; published online before print February 17 2004, 10.1073/pnas.0306845101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Jian Wu, Nianshu Zhang, Andrew Hayes, Kalliope Panoutsopoulou, and Stephen G. Oliver

Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation
PNAS 2004 101: 3148-3153; published online before print February 18 2004, 10.1073/pnas.0308321100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Boris Striepen, Andrea J. P. Pruijssers, Jinling Huang, Catherine Li, Marc-Jan Gubbels, Nwakaso N. Umejiego, Lizbeth Hedstrom, and Jessica C. Kissinger

Gene transfer in the evolution of parasite nucleotide biosynthesis
PNAS 2004 101: 3154-3159; published online before print February 18 2004, 10.1073/pnas.0304686101 [Abstract] [Full Text] [PDF] [Supporting Data Set]  

Konstantinos T. Konstantinidis and James M. Tiedje

Trends between gene content and genome size in prokaryotic species with larger genomes
PNAS 2004 101: 3160-3165; published online before print February 18 2004, 10.1073/pnas.0308653100 [Abstract] [Full Text] [PDF] [Supporting Information]  

Terrence M. Tumpey, Adolfo García-Sastre, Jeffery K. Taubenberger, Peter Palese, David E. Swayne, and Christopher F. Basler

Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
PNAS 2004 101: 3166-3171; published online before print February 12 2004, 10.1073/pnas.0308391100 [Abstract] [Full Text] [PDF]  

Neuroscience

Michele M. Maxwell, Piera Pasinelli, Aleksey G. Kazantsev, and Robert H. Brown, Jr.

RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells
PNAS 2004 101: 3178-3183; published online before print February 23 2004, 10.1073/pnas.0308726100 [Abstract] [Full Text] [PDF]  

Robert E. Hampson, Tim P. Pons, Terrence R. Stanford, and Sam A. Deadwyler

Categorization in the monkey hippocampus: A possible mechanism for encoding information into memory
PNAS 2004 101: 3184-3189; published online before print February 20 2004, 10.1073/pnas.0400162101 [Abstract] [Full Text] [PDF] [Supporting Information]  

Maria E. Grunwald, Jerry E. Mellem, Nathalie Strutz, Andres V. Maricq, and Joshua M. Kaplan

Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade
PNAS 2004 101: 3190-3195; published online before print February 23 2004, 10.1073/pnas.0306156101 [Abstract] [Full Text] [PDF]  

Wulf Haubensak, Alessio Attardo, Winfried Denk, and Wieland B. Huttner From The Cover: Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis PNAS 2004 101: 3196-3201; published online before print February 12 2004, 10.1073/pnas.0308600100 [Abstract] [Full Text] [PDF] [Supporting Information]

Masatoshi Suzuki, Lynda S. Wright, Padma Marwah, Henry A. Lardy, and Clive N. Svendsen

Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex
PNAS 2004 101: 3202-3207; published online before print February 18 2004, 10.1073/pnas.0307325101