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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 1-2. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

Hartmut Wekerle

Planting and pruning in the brain: MHC antigens involved in synaptic plasticity?
PNAS 2005 102: 3-4; published online before print December 27 2004, 10.1073/pnas.0408495101 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 17843 in issue 51 of volume 101

PHYSICAL SCIENCES

Chemistry

S. G. Ray, S. S. Daube, and R. Naaman

On the capturing of low-energy electrons by DNA
PNAS 2005 102: 15-19; published online before print December 22 2004, 10.1073/pnas.0407020102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ali Abo-Riziq, Louis Grace, Eyal Nir, Martin Kabelac, Pavel Hobza, and Mattanjah S. de Vries

Photochemical selectivity in guanine–cytosine base-pair structures
PNAS 2005 102: 20-23; published online before print December 23 2004, 10.1073/pnas.0408574102 [Abstract] [Full Text] [Figures Only] [PDF]  

Zhengrong Wu, Melissa Maderia, Joseph J. Barchi, Jr, Victor E. Marquez, and Ad Bax

Changes in DNA bending induced by restricting nucleotide ring pucker studied by weak alignment NMR spectroscopy
PNAS 2005 102: 24-28; published online before print December 23 2004, 10.1073/pnas.0408498102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Applied Biological Sciences

Brent S. Gaylord, Michelle R. Massie, Stuart C. Feinstein, and Guillermo C. Bazan

SNP detection using peptide nucleic acid probes and conjugated polymers: Applications in neurodegenerative disease identification
PNAS 2005 102: 34-39; published online before print December 23 2004, 10.1073/pnas.0407578101 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Carol E. O'Hear and Jefferson Foote

Antibody buffering of a ligand in vivo
PNAS 2005 102: 40-44; published online before print December 22 2004, 10.1073/pnas.0405797102 [Abstract] [Full Text] [Figures Only] [PDF]  

Biochemistry

S. G. Ray, S. S. Daube, and R. Naaman

On the capturing of low-energy electrons by DNA
PNAS 2005 102: 15-19; published online before print December 22 2004, 10.1073/pnas.0407020102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Helen M. Berman, Lynn F. Ten Eyck, David S. Goodsell, Nina M. Haste, Alexandr Kornev, and Susan S. Taylor

The cAMP binding domain: An ancient signaling module
PNAS 2005 102: 45-50; published online before print December 23 2004, 10.1073/pnas.0408579102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Vito Calderone, Benedikt Dolderer, Hans-Juergen Hartmann, Hartmut Echner, Claudio Luchinat, Cristina Del Bianco, Stefano Mangani, and Ulrich Weser

The crystal structure of yeast copper thionein: The solution of a long-lasting enigma
PNAS 2005 102: 51-56; published online before print December 21 2004, 10.1073/pnas.0408254101 [Abstract] [Full Text] [Figures Only] [PDF]  

D. Reichmann, O. Rahat, S. Albeck, R. Meged, O. Dym, and G. Schreiber From The Cover: The modular architecture of protein–protein binding interfaces PNAS 2005 102: 57-62; published online before print December 23 2004, 10.1073/pnas.0407280102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]

Baoying Liu, Sohee Hong, Zhanyun Tang, Hongtao Yu, and Chou-Zen Giam

HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule
PNAS 2005 102: 63-68; published online before print December 27 2004, 10.1073/pnas.0406424101 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jennifer Giordano-Coltart, Carol Y. Ying, Jean Gautier, and Jerard Hurwitz

Studies of the properties of human origin recognition complex and its Walker A motif mutants
PNAS 2005 102: 69-74; published online before print December 23 2004, 10.1073/pnas.0408690102 [Abstract] [Full Text] [Figures Only] [PDF]  

Younghee Sohn and Changwon Kang

Sequential multiple functions of the conserved sequence in sequence-specific termination by T7 RNA polymerase
PNAS 2005 102: 75-80; published online before print December 22 2004, 10.1073/pnas.0406581101 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Biophysics

Sudha Chakrapani and Anthony Auerbach

A speed limit for conformational change of an allosteric membrane protein
PNAS 2005 102: 87-92; published online before print December 23 2004, 10.1073/pnas.0406777102 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Andrey A. Sharov, Michael Fessing, Ruzanna Atoyan, Tatyana Y. Sharova, Carrie Haskell-Luevano, Lorin Weiner, Keiko Funa, Janice L. Brissette, Barbara A. Gilchrest, and Vladimir A. Botchkarev

Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway
PNAS 2005 102: 93-98; published online before print December 23 2004, 10.1073/pnas.0408455102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Sarah L. Pull, Jason M. Doherty, Jason C. Mills, Jeffrey I. Gordon, and Thaddeus S. Stappenbeck

Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury
PNAS 2005 102: 99-104; published online before print December 22 2004, 10.1073/pnas.0405979102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Scott A. Oakes, Luca Scorrano, Joseph T. Opferman, Michael C. Bassik, Mari Nishino, Tullio Pozzan, and Stanley J. Korsmeyer

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
PNAS 2005 102: 105-110; published online before print December 21 2004, 10.1073/pnas.0408352102 [Abstract] [Full Text] [Figures Only] [PDF]  

Elizabeth J. Renaud, David T. MacLaughlin, Esther Oliva, Bo R. Rueda, and Patricia K. Donahoe

Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance
PNAS 2005 102: 111-116; published online before print December 23 2004, 10.1073/pnas.0407772101 [Abstract] [Full Text] [Figures Only] [PDF]  

Yi Yang and Joseph Loscalzo

S-nitrosoprotein formation and localization in endothelial cells
PNAS 2005 102: 117-122; published online before print December 23 2004, 10.1073/pnas.0405989102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] [Online Correction to Supporting Figure 6]  

Dongfang Liu, Liang Xu, Fan Yang, Dongdong Li, Feili Gong, and Tao Xu

Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition
PNAS 2005 102: 123-127; published online before print December 23 2004, 10.1073/pnas.0405737102 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Julien Y. Bertrand, Sébastien Giroux, Rachel Golub, Michèle Klaine, Abdelali Jalil, Laurent Boucontet, Isabelle Godin, and Ana Cumano

Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin
PNAS 2005 102: 134-139; published online before print December 27 2004, 10.1073/pnas.0402270102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Evolution

James F. Gillooly, Andrew P. Allen, Geoffrey B. West, and James H. Brown

The rate of DNA evolution: Effects of body size and temperature on the molecular clock
PNAS 2005 102: 140-145; published online before print December 23 2004, 10.1073/pnas.0407735101 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendixes]  

Nansheng Chen, Shraddha Pai, Zhongying Zhao, Allan Mah, Rebecca Newbury, Robert C. Johnsen, Zeynep Altun, Donald G. Moerman, David L. Baillie, and Lincoln D. Stein Identification of a nematode chemosensory gene family PNAS 2005 102: 146-151; published online before print December 23 2004, 10.1073/pnas.0408307102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Genetics

Gad Kimmel and Ron Shamir

GERBIL: Genotype resolution and block identification using likelihood
PNAS 2005 102: 158-162; published online before print December 22 2004, 10.1073/pnas.0404730102 [Abstract] [Full Text] [Figures Only] [PDF]  

Hon-Ren Huang, Claire E. Rowe, Sabine Mohr, Yue Jiang, Alan M. Lambowitz, and Philip S. Perlman

The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function
PNAS 2005 102: 163-168; published online before print December 23 2004, 10.1073/pnas.0407896101 [Abstract] [Full Text] [Figures Only] [PDF]  

Immunology

Jan Klein and Nikolas Nikolaidis

The descent of the antibody-based immune system by gradual evolution
PNAS 2005 102: 169-174; published online before print December 23 2004, 10.1073/pnas.0408480102 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Francesca Cerimele, Traci Battle, Rebecca Lynch, David A. Frank, Emma Murad, Cynthia Cohen, Nada Macaron, John Sixbey, Kenneth Smith, Randolph S. Watnick, Aristidis Eliopoulos, Bahig Shehata, and Jack L. Arbiser

Reactive oxygen signaling and MAPK activation distinguish Epstein–Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma
PNAS 2005 102: 175-179; published online before print December 20 2004, 10.1073/pnas.0408381102 [Abstract] [Full Text] [Figures Only] [PDF]  

Marina Afanasyeva, Dimitrios Georgakopoulos, Diego F. Belardi, Djahida Bedja, DeLisa Fairweather, Yan Wang, Ziya Kaya, Kathleen L. Gabrielson, E. Rene Rodriguez, Patrizio Caturegli, David A. Kass, and Noel R. Rose

Impaired up-regulation of CD25 on CD4⁺ T cells in IFN- knockout mice is associated with progression of myocarditis to heart failure
PNAS 2005 102: 180-185; published online before print December 20 2004, 10.1073/pnas.0408241102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Guoshun Wang, Bruce A. Bunnell, Richard G. Painter, Blesilda C. Quiniones, Susan Tom, Nicholas A. Lanson, Jr, Jeffrey L. Spees, Donna Bertucci, Alexandra Peister, Daniel J. Weiss, Vincent G. Valentine, Darwin J. Prockop, and Jay K. Kolls

Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: Potential therapy for cystic fibrosis
PNAS 2005 102: 186-191; published online before print December 22 2004, 10.1073/pnas.0406266102 [Abstract] [Full Text] [Figures Only] [PDF]  

Hamdiye Erdal, Maria Berndtsson, Juan Castro, Ulf Brunk, Maria C. Shoshan, and Stig Linder

Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis
PNAS 2005 102: 192-197; published online before print December 23 2004, 10.1073/pnas.0408592102 [Abstract] [Full Text] [Figures Only] [PDF]  

Qi Long Lu, Adam Rabinowitz, Yun Chao Chen, Toshifumi Yokota, HaiFang Yin, Julia Alter, Atif Jadoon, George Bou-Gharios, and Terence Partridge From the Cover: Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles PNAS 2005 102: 198-203; published online before print December 17 2004, 10.1073/pnas.0406700102 [Abstract] [Full Text] [Figures Only] [PDF]

Philip M. Bauer, Jun Yu, Yan Chen, Reed Hickey, Pascal N. Bernatchez, Robin Looft-Wilson, Yan Huang, Frank Giordano, Radu V. Stan, and William C. Sessa

Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis
PNAS 2005 102: 204-209; published online before print December 22 2004, 10.1073/pnas.0406092102 [Abstract] [Full Text] [Figures Only] [PDF]  

David R. Shaffer, Agnes Viale, Ryota Ishiwata, Margaret Leversha, Semra Olgac, Katia Manova, Jaya Satagopan, Howard Scher, and Andrew Koff Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate PNAS 2005 102: 210-215; published online before print December 22 2004, 10.1073/pnas.0407362102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Li Ma, Rafael Perini, Webb McKnight, Michael Dicay, Andre Klein, Morley D. Hollenberg, and John L. Wallace

Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets
PNAS 2005 102: 216-220; published online before print December 22 2004, 10.1073/pnas.0406682102 [Abstract] [Full Text] [Figures Only] [PDF]  

Microbiology

Neuroscience

Joshua A. Weiner, Xiaozhong Wang, Juan Carlos Tapia, and Joshua R. Sanes Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Gamma protocadherins are required for synaptic development in the spinal cord PNAS 2005 102: 8-14; published online before print December 1 2004, 10.1073/pnas.0407931101 [Abstract] [Full Text] [Figures Only] [PDF]

Bin Zhang, Arpita Maiti, Sharon Shively, Fara Lakhani, Gaye McDonald-Jones, Jennifer Bruce, Edward B. Lee, Sharon X. Xie, Sonali Joyce, Chi Li, Philip M. Toleikis, Virginia M.-Y. Lee, and John Q. Trojanowski

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
PNAS 2005 102: 227-231; published online before print December 22 2004, 10.1073/pnas.0406361102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yan-You Huang and Eric R. Kandel frequency stimulation up-regulates the synaptic strength of the pathway from CA1 to subiculum region of hippocampus PNAS 2005 102: 232-237; published online before print December 27 2004, 10.1073/pnas.0408368102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Roberto Chiesa, Pedro Piccardo, Sara Dossena, Lisa Nowoslawski, Kevin A. Roth, Bernardino Ghetti, and David A. Harris

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease
PNAS 2005 102: 238-243; published online before print December 23 2004, 10.1073/pnas.0406173102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Marcus J. Calkins, Rebekah J. Jakel, Delinda A. Johnson, Kaimin Chan, Yuet Wai Kan, and Jeffrey A. Johnson Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription PNAS 2005 102: 244-249; published online before print December 20 2004, 10.1073/pnas.0408487101 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE