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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 4217-4218. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

Claire J. Tomlin and Jeffrey D. Axelrod

Understanding biology by reverse engineering the control
PNAS 2005 102: 4219-4220; published online before print March 14 2005, 10.1073/pnas.0500276102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 2736 in issue 8 of volume 102

PHYSICAL SCIENCES

Applied Mathematics

Physics

Akira Nakayama and Nancy Makri

Simulation of dynamical properties of normal and superfluid helium
PNAS 2005 102: 4230-4234; published online before print March 7 2005, 10.1073/pnas.0501127102 [Abstract] [Full Text] [Figures Only] [PDF]  

Statistics

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Biochemistry

Alexander Jilek, Christa Mollay, Christa Tippelt, Jacques Grassi, Giuseppina Mignogna, Johannes Müllegger, Veronika Sander, Christine Fehrer, Donatella Barra, and Günther Kreil

Biosynthesis of a D-amino acid in peptide linkage by an enzyme from frog skin secretions
PNAS 2005 102: 4235-4239; published online before print March 9 2005, 10.1073/pnas.0500789102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Hua-Poo Su, Scott C. Garman, Timothy J. Allison, Christiana Fogg, Bernard Moss, and David N. Garboczi

The 1.51-Å structure of the poxvirus L1 protein, a target of potent neutralizing antibodies
PNAS 2005 102: 4240-4245; published online before print March 10 2005, 10.1073/pnas.0501103102 [Abstract] [Full Text] [Figures Only] [PDF]  

Tanja Henrichs, Natasha Mikhaleva, Charlotte Conz, Elke Deuerling, Dana Boyd, Adrian Zelazny, Eitan Bibi, Nenad Ban, and Michael Ehrmann

Target-directed proteolysis at the ribosome
PNAS 2005 102: 4246-4251. [Abstract] [Full Text] [Figures Only] [PDF]  

C. Kendziorski, R. A. Irizarry, K.-S. Chen, J. D. Haag, and M. N. Gould On the utility of pooling biological samples in microarray experiments PNAS 2005 102: 4252-4257; published online before print March 8 2005, 10.1073/pnas.0500607102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Qinshan Gao, Biswadip Das, Fred Sherman, and Lynne E. Maquat

Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast
PNAS 2005 102: 4258-4263; published online before print March 7 2005, 10.1073/pnas.0500684102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Steven G. Van Lanen, John S. Reader, Manal A. Swairjo, Valérie de Crécy-Lagard, Bobby Lee, and Dirk Iwata-Reuyl

From cyclohydrolase to oxidoreductase: Discovery of nitrile reductase activity in a common fold
PNAS 2005 102: 4264-4269; published online before print March 14 2005, 10.1073/pnas.0408056102 [Abstract] [Full Text] [Figures Only] [PDF]  

Anita U. Rao, Lynn K. Carta, Emmanuel Lesuisse, and Iqbal Hamza

Lack of heme synthesis in a free-living eukaryote
PNAS 2005 102: 4270-4275; published online before print March 14 2005, 10.1073/pnas.0500877102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Benoit Poulin, Fujio Sekiya, and Sue Goo Rhee

Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-1
PNAS 2005 102: 4276-4281; published online before print March 11 2005, 10.1073/pnas.0409590102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Steven T. Whitten, Bertrand García-Moreno E., and Vincent J. Hilser

Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins
PNAS 2005 102: 4282-4287; published online before print March 14 2005, 10.1073/pnas.0407499102 [Abstract] [Full Text] [Figures Only] [PDF]  

Yoko Hirono-Hara, Koji Ishizuka, Kazuhiko Kinosita, Jr., Masasuke Yoshida, and Hiroyuki Noji

Activation of pausing F₁ motor by external force
PNAS 2005 102: 4288-4293; published online before print March 9 2005, 10.1073/pnas.0406486102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movie]  

Rodolfo M. Rasia, Carlos W. Bertoncini, Derek Marsh, Wolfgang Hoyer, Dmitry Cherny, Markus Zweckstetter, Christian Griesinger, Thomas M. Jovin, and Claudio O. Fernández

Structural characterization of copper(II) binding to -synuclein: Insights into the bioinorganic chemistry of Parkinson's disease
PNAS 2005 102: 4294-4299; published online before print March 14 2005, 10.1073/pnas.0407881102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Cell Biology

Hyun Joon Kong, Thomas R. Polte, Eben Alsberg, and David J. Mooney

FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness
PNAS 2005 102: 4300-4305; published online before print March 14 2005, 10.1073/pnas.0405873102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Dao-Hong Lin, Hyacinth Sterling, Zhijian Wang, Elisa Babilonia, Baofeng Yang, Ke Dong, Steven C. Hebert, Gerhard Giebisch, and Wen-Hui Wang

ROMK1 channel activity is regulated by monoubiquitination
PNAS 2005 102: 4306-4311; published online before print March 14 2005, 10.1073/pnas.0409767102 [Abstract] [Full Text] [Figures Only] [PDF]  

Teresa Sanchez, Shobha Thangada, Ming-Tao Wu, Christopher D. Kontos, Dianqing Wu, Hong Wu, and Timothy Hla

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
PNAS 2005 102: 4312-4317; published online before print March 11 2005, 10.1073/pnas.0409784102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jeffrey J. Tung, David V. Hansen, Kenneth H. Ban, Alexander V. Loktev, Matthew K. Summers, John R. Adler, III, and Peter K. Jackson A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs PNAS 2005 102: 4318-4323; published online before print March 7 2005, 10.1073/pnas.0501108102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Alana L. Welm, Suwon Kim, Bryan E. Welm, and J. Michael Bishop MET and MYC cooperate in mammary tumorigenesis PNAS 2005 102: 4324-4329; published online before print February 28 2005, 10.1073/pnas.0500470102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Barrington G. Burnett and Randall N. Pittman

The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation
PNAS 2005 102: 4330-4335; published online before print March 14 2005, 10.1073/pnas.0407252102 [Abstract] [Full Text] [Figures Only] [PDF]  

Ann M. Winter-Vann, Rudi A. Baron, Waihay Wong, June dela Cruz, John D. York, David M. Gooden, Martin O. Bergo, Stephen G. Young, Eric J. Toone, and Patrick J. Casey

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
PNAS 2005 102: 4336-4341. [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Eileithyia Swanton, Andrew Holland, Stephen High, and Philip Woodman

Disease-associated mutations cause premature oligomerization of myelin proteolipid protein in the endoplasmic reticulum
PNAS 2005 102: 4342-4347; published online before print March 7 2005, 10.1073/pnas.0407287102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Valerie A. Kickhoefer, Yvette Garcia, Yeshi Mikyas, Erik Johansson, Jing C. Zhou, Sujna Raval-Fernandes, Payam Minoofar, Jeffrey I. Zink, Bruce Dunn, Phoebe L. Stewart, and Leonard H. Rome

Engineering of vault nanocapsules with enzymatic and fluorescent properties
PNAS 2005 102: 4348-4352; published online before print March 7 2005, 10.1073/pnas.0500929102 [Abstract] [Full Text] [Figures Only] [PDF]  

M. I. Molodtsov, E. L. Grishchuk, A. K. Efremov, J. R. McIntosh, and F. I. Ataullakhanov From the Cover: Force production by depolymerizing microtubules: A theoretical study PNAS 2005 102: 4353-4358; published online before print March 14 2005, 10.1073/pnas.0501142102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendixes]

R. Mark Grady, Daniel A. Starr, Gail L. Ackerman, Joshua R. Sanes, and Min Han From the Cover: Syne proteins anchor muscle nuclei at the neuromuscular junction PNAS 2005 102: 4359-4364; published online before print March 4 2005, 10.1073/pnas.0500711102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]

Chinthalapally V. Rao, Yang-Ming Yang, Malisetty V. Swamy, Tongyi Liu, Yuqiang Fang, Radma Mahmood, Meena Jhanwar-Uniyal, and Wei Dai

Colonic tumorigenesis in BubR1^+/–Apc^Min/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
PNAS 2005 102: 4365-4370; published online before print March 14 2005, 10.1073/pnas.0407822102 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Jeffrey M. Gross and John E. Dowling

Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retina
PNAS 2005 102: 4371-4376; published online before print March 8 2005, 10.1073/pnas.0501061102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Alida Filippi, Natascia Tiso, Gianluca Deflorian, Elisabetta Zecchin, Marino Bortolussi, and Francesco Argenton The basic helix–loop–helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord PNAS 2005 102: 4377-4382; published online before print February 24 2005, 10.1073/pnas.0407284102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Ecology

Katharine N. Suding, Scott L. Collins, Laura Gough, Christopher Clark, Elsa E. Cleland, Katherine L. Gross, Daniel G. Milchunas, and Steven Pennings

Functional- and abundance-based mechanisms explain diversity loss due to N fertilization
PNAS 2005 102: 4387-4392; published online before print March 8 2005, 10.1073/pnas.0408648102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Val H. Smith, Bryan L. Foster, James P. Grover, Robert D. Holt, Mathew A. Leibold, and Frank deNoyelles, Jr.

Phytoplankton species richness scales consistently from laboratory microcosms to the world's oceans
PNAS 2005 102: 4393-4396; published online before print March 7 2005, 10.1073/pnas.0500094102 [Abstract] [Full Text] [Figures Only] [PDF]  

Environmental Sciences

John P. Smol, Alexander P. Wolfe, H. John B. Birks, Marianne S. V. Douglas, Vivienne J. Jones, Atte Korhola, Reinhard Pienitz, Kathleen Rühland, Sanna Sorvari, Dermot Antoniades, Stephen J. Brooks, Marie-Andrée Fallu, Mike Hughes, Bronwyn E. Keatley, Tamsin E. Laing, Neal Michelutti, Larisa Nazarova, Marjut Nyman, Andrew M. Paterson, Bianca Perren, Roberto Quinlan, Milla Rautio, Émilie Saulnier-Talbot, Susanna Siitonen, Nadia Solovieva, and Jan Weckström

Climate-driven regime shifts in the biological communities of arctic lakes
PNAS 2005 102: 4397-4402; published online before print February 28 2005, 10.1073/pnas.0500245102 [Abstract] [Full Text] [Figures Only] [PDF]  

Evolution

Scott William Roy and Walter Gilbert

Resolution of a deep animal divergence by the pattern of intron conservation
PNAS 2005 102: 4403-4408; published online before print March 15 2005, 10.1073/pnas.0409891102 [Abstract] [Full Text] [Figures Only] [PDF]  

Christina M. Nielsen-Marsh, Michael P. Richards, Peter V. Hauschka, Jane E. Thomas-Oates, Erik Trinkaus, Paul B. Pettitt, Ivor Karavanic, Hendrik Poinar, and Matthew J. Collins From the Cover: Osteocalcin protein sequences of Neanderthals and modern primates PNAS 2005 102: 4409-4413; published online before print March 7 2005, 10.1073/pnas.0500450102 [Abstract] [Full Text] [Figures Only] [PDF]

Manfred Milinski, Siân Griffiths, K. Mathias Wegner, Thorsten B. H. Reusch, Annette Haas-Assenbaum, and Thomas Boehm

Mate choice decisions of stickleback females predictably modified by MHC peptide ligands
PNAS 2005 102: 4414-4418; published online before print March 8 2005, 10.1073/pnas.0408264102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael R. Gillings, Marita P. Holley, H. W. Stokes, and Andrew J. Holmes

Integrons in Xanthomonas: A source of species genome diversity
PNAS 2005 102: 4419-4424; published online before print March 8 2005, 10.1073/pnas.0406620102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Stéphane Hué, Deenan Pillay, Jonathan P. Clewley, and Oliver G. Pybus

Genetic analysis reveals the complex structure of HIV-1 transmission within defined risk groups
PNAS 2005 102: 4425-4429; published online before print March 14 2005, 10.1073/pnas.0407534102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Stepánka Vanácová, Weihong Yan, Jane M. Carlton, and Patricia J. Johnson Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis PNAS 2005 102: 4430-4435; published online before print March 11 2005, 10.1073/pnas.0407500102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Tae-Kun Seo, Hirohisa Kishino, and Jeffrey L. Thorne

Incorporating gene-specific variation when inferring and evaluating optimal evolutionary tree topologies from multilocus sequence data
PNAS 2005 102: 4436-4441; published online before print March 11 2005, 10.1073/pnas.0408313102 [Abstract] [Full Text] [PDF] [Supporting Information]  

Shelley D. Copley, Eric Smith, and Harold J. Morowitz

A mechanism for the association of amino acids with their codons and the origin of the genetic code
PNAS 2005 102: 4442-4447; published online before print March 11 2005, 10.1073/pnas.0501049102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ana Grande-Pérez, Ester Lázaro, Pedro Lowenstein, Esteban Domingo, and Susanna C. Manrubia

Suppression of viral infectivity through lethal defection
PNAS 2005 102: 4448-4452; published online before print March 14 2005, 10.1073/pnas.0408871102 [Abstract] [Full Text] [Figures Only] [PDF]  

Genetics

Viktor Stolc, Manoj Pratim Samanta, Waraporn Tongprasit, Himanshu Sethi, Shoudan Liang, David C. Nelson, Adrian Hegeman, Clark Nelson, David Rancour, Sebastian Bednarek, Eldon L. Ulrich, Qin Zhao, Russell L. Wrobel, Craig S. Newman, Brian G. Fox, George N. Phillips, Jr., John L. Markley, and Michael R. Sussman

Identification of transcribed sequences in Arabidopsis thaliana by using high-resolution genome tiling arrays
PNAS 2005 102: 4453-4458; published online before print March 8 2005, 10.1073/pnas.0408203102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting information]  

Xinmin Zhang, Duncan T. Odom, Seung-Hoi Koo, Michael D. Conkright, Gianluca Canettieri, Jennifer Best, Huaming Chen, Richard Jenner, Elizabeth Herbolsheimer, Elizabeth Jacobsen, Shilpa Kadam, Joseph R. Ecker, Beverly Emerson, John B. Hogenesch, Terry Unterman, Richard A. Young, and Marc Montminy

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
PNAS 2005 102: 4459-4464; published online before print March 7 2005, 10.1073/pnas.0501076102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sine L. Svenningsen, Nina Costantino, Donald L. Court, and Sankar Adhya

On the role of Cro in prophage induction
PNAS 2005 102: 4465-4469; published online before print February 23 2005, 10.1073/pnas.0409839102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Oren Kobiler, Assaf Rokney, Nir Friedman, Donald L. Court, Joel Stavans, and Amos B. Oppenheim Quantitative kinetic analysis of the bacteriophage genetic network PNAS 2005 102: 4470-4475; published online before print February 22 2005, 10.1073/pnas.0500670102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

James H. Thomas, Joanna L. Kelley, Hugh M. Robertson, Kim Ly, and Willie J. Swanson

Adaptive evolution in the SRZ chemoreceptor families of Caenorhabditis elegans and Caenorhabditis briggsae
PNAS 2005 102: 4476-4481; published online before print March 10 2005, 10.1073/pnas.0406469102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Lorinda K. Anderson, Suzanne M. Royer, Scott L. Page, Kim S. McKim, Ann Lai, Mary A. Lilly, and R. Scott Hawley

Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex
PNAS 2005 102: 4482-4487; published online before print March 14 2005, 10.1073/pnas.0500172102 [Abstract] [Full Text] [Figures Only] [PDF]  

Bryce E. Nickels, Sean J. Garrity, Vladimir Mekler, Leonid Minakhin, Konstantin Severinov, Richard H. Ebright, and Ann Hochschild

The interaction between ⁷⁰ and the -flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation
PNAS 2005 102: 4488-4493; published online before print March 10 2005, 10.1073/pnas.0409850102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Seung Wook Oh, Arnab Mukhopadhyay, Nenad Svrzikapa, Feng Jiang, Roger J. Davis, and Heidi A. Tissenbaum

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
PNAS 2005 102: 4494-4499; published online before print March 14 2005, 10.1073/pnas.0500749102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Tomás Vacík, Michael Ort, Sona Gregorová, Petr Strnad, Radek Blatny, Nathalie Conte, Allan Bradley, Jan Bures, and Jirí Forejt Segmental trisomy of chromosome 17: A mouse model of human aneuploidy syndromes PNAS 2005 102: 4500-4505; published online before print March 8 2005, 10.1073/pnas.0500802102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Immunology

Ai Kotani, Il-mi Okazaki, Masamichi Muramatsu, Kazuo Kinoshita, Nasim A. Begum, Toshiharu Nakajima, Hirohisa Saito, and Tasuku Honjo

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
PNAS 2005 102: 4506-4511; published online before print March 14 2005, 10.1073/pnas.0500830102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Michael R. Betts, Barbara Exley, David A. Price, Anju Bansal, Zenaido Tres Camacho, Vanessa Teaberry, Sadie M. West, David R. Ambrozak, Georgia Tomaras, Mario Roederer, J. Michael Kilby, Jim Tartaglia, Robert Belshe, Feng Gao, Daniel C. Douek, Kent J. Weinhold, Richard A. Koup, Paul Goepfert, and Guido Ferrari Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection PNAS 2005 102: 4512-4517; published online before print March 7 2005, 10.1073/pnas.0408773102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Lili Yang and David Baltimore Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells PNAS 2005 102: 4518-4523; published online before print March 9 2005, 10.1073/pnas.0500600102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Hirotada Kojima, Takanori Sasaki, Tohru Ishitani, Shun-ichiro Iemura, Hong Zhao, Shuhei Kaneko, Hiroyuki Kunimoto, Tohru Natsume, Kunihiro Matsumoto, and Koichi Nakajima

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGF-activated kinase 1 for STAT3 Ser-727 phosphorylation
PNAS 2005 102: 4524-4529; published online before print March 11 2005, 10.1073/pnas.0500679102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Stewart T. Chang, Jennifer J. Linderman, and Denise E. Kirschner

Multiple mechanisms allow Mycobacterium tuberculosis to continuously inhibit MHC class II-mediated antigen presentation by macrophages
PNAS 2005 102: 4530-4535; published online before print March 14 2005, 10.1073/pnas.0500362102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ning Zhang, Saadet Inan, Alan Cowan, Ronghua Sun, Ji Ming Wang, Thomas J. Rogers, Michael Caterina, and Joost J. Oppenheim

A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1
PNAS 2005 102: 4536-4541; published online before print March 11 2005, 10.1073/pnas.0406030102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Medical Sciences

Charles Cox, Graham Bignell, Chris Greenman, Arne Stabenau, William Warren, Philip Stephens, Helen Davies, Stephen Watt, Jon Teague, Sara Edkins, Ewan Birney, Douglas F. Easton, Richard Wooster, P. Andrew Futreal, and Michael R. Stratton

A survey of homozygous deletions in human cancer genomes
PNAS 2005 102: 4542-4547; published online before print March 10 2005, 10.1073/pnas.0408593102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Edward A. Weinstein, Takahiro Yano, Lin-Sheng Li, David Avarbock, Andrew Avarbock, Douglas Helm, Andrew A. McColm, Ken Duncan, John T. Lonsdale, and Harvey Rubin

Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs
PNAS 2005 102: 4548-4553; published online before print March 14 2005, 10.1073/pnas.0500469102 [Abstract] [Full Text] [Figures Only] [PDF]  

Wilhelm Stoffel, Britta Jenke, Barbara Blöck, Markus Zumbansen, and Jürgen Koebke

Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development
PNAS 2005 102: 4554-4559; published online before print March 11 2005, 10.1073/pnas.0406380102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Jean-Christophe Meunier, Ronald E. Engle, Kristina Faulk, Ming Zhao, Birke Bartosch, Harvey Alter, Suzanne U. Emerson, Francois-Loic Cosset, Robert H. Purcell, and Jens Bukh

Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1
PNAS 2005 102: 4560-4565; published online before print March 14 2005, 10.1073/pnas.0501275102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael G. Anderson, Richard T. Libby, Douglas B. Gould, Richard S. Smith, and Simon W. M. John High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma PNAS 2005 102: 4566-4571; published online before print March 9 2005, 10.1073/pnas.0407357102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Toshie Iwai, Takashi Kudo, Risa Kawamoto, Tomomi Kubota, Akira Togayachi, Toru Hiruma, Tomoko Okada, Toru Kawamoto, Kyoei Morozumi, and Hisashi Narimatsu

Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells
PNAS 2005 102: 4572-4577; published online before print March 8 2005, 10.1073/pnas.0407983102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Moon G. Choi, Hae S. Koh, Daniel Kluess, Daniel O'Connor, Anshu Mathur, George A. Truskey, Janet Rubin, David X. F. Zhou, and K.-L. Paul Sung

Effects of titanium particle size on osteoblast functions in vitro and in vivo
PNAS 2005 102: 4578-4583; published online before print March 8 2005, 10.1073/pnas.0500693102 [Abstract] [Full Text] [Figures Only] [PDF]  

Albena T. Dinkova-Kostova, Karen T. Liby, Katherine K. Stephenson, W. David Holtzclaw, Xiangqun Gao, Nanjoo Suh, Charlotte Williams, Renee Risingsong, Tadashi Honda, Gordon W. Gribble, Michael B. Sporn, and Paul Talalay

Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
PNAS 2005 102: 4584-4589; published online before print March 14 2005, 10.1073/pnas.0500815102 [Abstract] [Full Text] [Figures Only] [PDF]  

Microbiology

Laurent Terradot, Richard Bayliss, Clasien Oomen, Gordon A. Leonard, Christian Baron, and Gabriel Waksman

Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori
PNAS 2005 102: 4596-4601; published online before print March 11 2005, 10.1073/pnas.0408927102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

V. Hok, E. Save, P. P. Lenck-Santini, and B. Poucet

Coding for spatial goals in the prelimbic/infralimbic area of the rat frontal cortex
PNAS 2005 102: 4602-4607; published online before print March 10 2005, 10.1073/pnas.0407332102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Andrea E. Kudwa, Cristian Bodo, Jan-Åke Gustafsson, and Emilie F. Rissman

A previously uncharacterized role for estrogen receptor : Defeminization of male brain and behavior
PNAS 2005 102: 4608-4612; published online before print March 10 2005, 10.1073/pnas.0500752102 [Abstract] [Full Text] [Figures Only] [PDF]  

Hailan Hu, Ming Li, Juan-Pablo Labrador, Jason McEwen, Eric C. Lai, Corey S. Goodman, and Greg J. Bashaw

Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion
PNAS 2005 102: 4613-4618; published online before print March 8 2005, 10.1073/pnas.0409325102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neri Kafkafi, Yoav Benjamini, Anat Sakov, Greg I. Elmer, and Ilan Golani

Genotype–environment interactions in mouse behavior: A way out of the problem
PNAS 2005 102: 4619-4624; published online before print March 11 2005, 10.1073/pnas.0409554102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Wado Akamatsu, Hiroaki Fujihara, Takayuki Mitsuhashi, Masato Yano, Shinsuke Shibata, Yoshika Hayakawa, Hirotaka James Okano, Shin-ichi Sakakibara, Hiroshi Takano, Toshiya Takano, Takao Takahashi, Tetsuo Noda, and Hideyuki Okano

The RNA-binding protein HuD regulates neuronal cell identity and maturation
PNAS 2005 102: 4625-4630; published online before print March 11 2005, 10.1073/pnas.0407523102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Chris Tailby, Layne L. Wright, Andrew B. Metha, and Mike B. Calford

Activity-dependent maintenance and growth of dendrites in adult cortex
PNAS 2005 102: 4631-4636; published online before print March 14 2005, 10.1073/pnas.0402747102 [Abstract] [Full Text] [Figures Only] [PDF]  

Pharmacology

Rosario Jimenez, Elizabeth Belcher, Shiranee Sriskandan, Ruth Lucas, Shaun McMaster, Ivana Vojnovic, Timothy D. Warner, and Jane A. Mitchell

Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle
PNAS 2005 102: 4637-4642; published online before print March 8 2005, 10.1073/pnas.0407655101 [Abstract] [Full Text] [Figures Only] [PDF]  

Physiology

Hana Cho, Doyun Lee, Suk Ho Lee, and Won-Kyung Ho

Receptor-induced depletion of phosphatidylinositol 4,5-bisphosphate inhibits inwardly rectifying K⁺ channels in a receptor-specific manner
PNAS 2005 102: 4643-4648; published online before print March 14 2005, 10.1073/pnas.0408844102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Plant Biology

Chloé Fourquin, Marion Vinauger-Douard, Bruno Fogliani, Christian Dumas, and Charles P. Scutt

Evidence that CRABS CLAW and TOUSLED have conserved their roles in carpel development since the ancestor of the extant angiosperms
PNAS 2005 102: 4649-4654; published online before print March 14 2005, 10.1073/pnas.0409577102 [Abstract] [Full Text] [Figures Only] [PDF]  

CORRECTIONS

Correction for Bonnet et al., Detection of 91 potential conserved plant microRNAs in Arabidopsis thaliana and Oryza sativa identifies important target genes, PNAS 2004 101:11511-11516 [Extract] [Full Text] [PDF]  

Correction for Yang et al., S-nitrosoprotein formation and localization in endothelial cells, PNAS 2005 102:117-122 [Extract] [Full Text] [PDF]