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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 4657-4658. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

Michael Brenowitz, Dorothy A. Erie, and Mark R. Chance

Catching RNA polymerase in the act of binding: Intermediates in transcription illuminated by synchrotron footprinting
PNAS 2005 102: 4659-4660; published online before print March 21 2005, 10.1073/pnas.0501152102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 4706

Luis Aragón

Sumoylation: A new wrestler in the DNA repair ring
PNAS 2005 102: 4661-4662; published online before print March 21 2005, 10.1073/pnas.0501342102 [Extract] [Full Text] [PDF]  
See companion article on page 4777

PHYSICAL SCIENCES

Applied Physical Sciences

Richard A. Gray and Nipon Chattipakorn

Termination of spiral waves during cardiac fibrillation via shock-induced phase resetting
PNAS 2005 102: 4672-4677; published online before print March 15 2005, 10.1073/pnas.0407860102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chemistry

Christophe Letondor, Nicolas Humbert, and Thomas R. Ward

Artificial metalloenzymes based on biotin-avidin technology for the enantioselective reduction of ketones by transfer hydrogenation
PNAS 2005 102: 4683-4687; published online before print March 16 2005, 10.1073/pnas.0409684102 [Abstract] [Full Text] [Figures Only] [PDF]  

Engineering

Pankaj Karande, Amit Jain, Kaitlin Ergun, Vincent Kispersky, and Samir Mitragotri

Design principles of chemical penetration enhancers for transdermal drug delivery
PNAS 2005 102: 4688-4693; published online before print March 17 2005, 10.1073/pnas.0501176102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Geophysics

Bruce D. Malamud, James D. A. Millington, and George L. W. Perry

Characterizing wildfire regimes in the United States
PNAS 2005 102: 4694-4699; published online before print March 21 2005, 10.1073/pnas.0500880102 [Abstract] [Full Text] [Figures Only] [PDF]  

Mathematics

George E. Andrews Inaugural Article by a Recently Elected Academy Member: Inaugural Article: Partitions with short sequences and mock theta functions PNAS 2005 102: 4666-4671; published online before print February 16 2005, 10.1073/pnas.0500218102 [Abstract] [Full Text] [PDF]

SOCIAL SCIENCES

Social Sciences

BIOLOGICAL SCIENCES

Applied Biological Sciences

Hui Song, Renxiao Wang, Shaomeng Wang, and Jiayuh Lin

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
PNAS 2005 102: 4700-4705; published online before print March 21 2005, 10.1073/pnas.0409894102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

Guanghan Gao, Agda M. Simpson, Xuedong Kang, Kestrel Rogers, Martina Nebohacova, Feng Li, and Larry Simpson

Functional complementation of Trypanosoma brucei RNA in vitro editing with recombinant RNA ligase
PNAS 2005 102: 4712-4717; published online before print March 21 2005, 10.1073/pnas.0500553102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Fernando Rodríguez, Catherine C. Allende, and Jorge E. Allende

Protein kinase casein kinase 2 holoenzyme produced ectopically in human cells can be exported to the external side of the cellular membrane
PNAS 2005 102: 4718-4723; published online before print March 17 2005, 10.1073/pnas.0501074102 [Abstract] [Full Text] [Figures Only] [PDF]  

Kevin D. Healy, Janeen L. Vanhooke, Jean M. Prahl, and Hector F. DeLuca

Parathyroid hormone decreases renal vitamin D receptor expression in vivo
PNAS 2005 102: 4724-4728; published online before print March 15 2005, 10.1073/pnas.0501312102 [Abstract] [Full Text] [Figures Only] [PDF]  

Biophysics

Friedrich Förster, Ohad Medalia, Nathan Zauberman, Wolfgang Baumeister, and Deborah Fass

Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography
PNAS 2005 102: 4729-4734; published online before print March 17 2005, 10.1073/pnas.0409178102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Maria Rosario Fernandez-Fernandez, Dmitry B. Veprintsev, and Alan R. Fersht

Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor
PNAS 2005 102: 4735-4740; published online before print March 21 2005, 10.1073/pnas.0501459102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Haripada Maity, Mita Maity, Mallela M. G. Krishna, Leland Mayne, and S. Walter Englander

Protein folding: The stepwise assembly of foldon units
PNAS 2005 102: 4741-4746; published online before print March 17 2005, 10.1073/pnas.0501043102 [Abstract] [Full Text] [Figures Only] [PDF]  

J. Zamoon, F. Nitu, C. Karim, D. D. Thomas, and G. Veglia

Mapping the interaction surface of a membrane protein: Unveiling the conformational switch of phospholamban in calcium pump regulation
PNAS 2005 102: 4747-4752; published online before print March 21 2005, 10.1073/pnas.0406039102 [Abstract] [Full Text] [Figures Only] [PDF]  

Margaret S. Cheung, Dmitri Klimov, and D. Thirumalai

Molecular crowding enhances native state stability and refolding rates of globular proteins
PNAS 2005 102: 4753-4758; published online before print March 21 2005, 10.1073/pnas.0409630102 [Abstract] [Full Text] [Figures Only] [PDF]  

Tomoyo Sakata, Yuling Yan, and Gerard Marriott

Optical switching of dipolar interactions on proteins
PNAS 2005 102: 4759-4764; published online before print March 16 2005, 10.1073/pnas.0405265102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Chiaki Nishimura, H. Jane Dyson, and Peter E. Wright

Enhanced picture of protein-folding intermediates using organic solvents in H/D exchange and quench-flow experiments
PNAS 2005 102: 4765-4770; published online before print March 15 2005, 10.1073/pnas.0409538102 [Abstract] [Full Text] [Figures Only] [PDF]  

Sandeep Krishna, Bidisha Banerjee, T. V. Ramakrishnan, and G. V. Shivashankar

Stochastic simulations of the origins and implications of long-tailed distributions in gene expression
PNAS 2005 102: 4771-4776; published online before print March 16 2005, 10.1073/pnas.0406415102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Cell Biology

Developmental Biology

Takako Kondo, Scott A. Johnson, Mervin C. Yoder, Raymond Romand, and Eri Hashino From The Cover: Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells PNAS 2005 102: 4789-4794; published online before print March 18 2005, 10.1073/pnas.0408239102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Ecology

Bruce D. Malamud, James D. A. Millington, and George L. W. Perry

Characterizing wildfire regimes in the United States
PNAS 2005 102: 4694-4699; published online before print March 21 2005, 10.1073/pnas.0500880102 [Abstract] [Full Text] [Figures Only] [PDF]  

Genetics

Elliott H. Margulies, Jade P. Vinson, NISC Comparative Sequencing Program, Webb Miller, David B. Jaffe, Kerstin Lindblad-Toh, Jean L. Chang, Eric D. Green, Eric S. Lander, James C. Mullikin, and Michele Clamp

An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing
PNAS 2005 102: 4795-4800; published online before print March 18 2005, 10.1073/pnas.0409882102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

J. Perren Cobb, Michael N. Mindrinos, Carol Miller-Graziano, Steve E. Calvano, Henry V. Baker, Wenzhong Xiao, Krzysztof Laudanski, Bernard H. Brownstein, Constance M. Elson, Douglas L. Hayden, David N. Herndon, Stephen F. Lowry, Ronald V. Maier, David A. Schoenfeld, Lyle L. Moldawer, Ronald W. Davis, Ronald G. Tompkins, Inflammation and Host Response to Injury Large-Scale Collaborative Research Program, Henry V. Baker, Paul Bankey, Timothy Billiar, Bernard H. Brownstein, Steve E. Calvano, David Camp, Irshad Chaudry, J. Perren Cobb, Ronald W. Davis, Constance M. Elson, Bradley Freeman, Richard Gamelli, Nicole Gibran, Brian Harbrecht, Douglas L. Hayden, Wyrta Heagy, David Heimbach, David N. Herndon, Jureta Horton, John Hunt, Krzysztof Laudanski, James Lederer, Stephen F. Lowry, Ronald V. Maier, John Mannick, Bruce McKinley, Carol Miller-Graziano, Michael N. Mindrinos, Joseph Minei, Lyle L. Moldawer, Ernest Moore, Frederick Moore, Robert Munford, Avery Nathens, Grant O'Keefe, Gary Purdue, Laurence Rahme, Daniel Remick, Matthew Sailors, David A. Schoenfeld, Michael Shapiro, Geoffrey Silver, Richard Smith, Gregory Stephanopoulos, Gary Stormo, Ronald G. Tompkins, Mehmet Toner, Shaw Warren, Michael West, Steven Wolfe, Wenzhong Xiao, and Vernon Young Application of genome-wide expression analysis to human health and disease PNAS 2005 102: 4801-4806; published online before print March 21 2005, 10.1073/pnas.0409768102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Bernadette Neve, Martin E. Fernandez-Zapico, Vered Ashkenazi-Katalan, Christian Dina, Yasmin H. Hamid, Erik Joly, Emmanuel Vaillant, Yamina Benmezroua, Emmanuelle Durand, Nicolas Bakaher, Valerie Delannoy, Martine Vaxillaire, Tiffany Cook, Geesje M. Dallinga-Thie, Hans Jansen, Marie-Aline Charles, Karine Clément, Pilar Galan, Serge Hercberg, Nicole Helbecque, Guillaume Charpentier, Marc Prentki, Torben Hansen, Oluf Pedersen, Raul Urrutia, Danielle Melloul, and Philippe Froguel From The Cover: Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function PNAS 2005 102: 4807-4812; published online before print March 17 2005, 10.1073/pnas.0409177102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Jiguo Chen and Ivan Sadowski

Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements
PNAS 2005 102: 4813-4818; published online before print March 21 2005, 10.1073/pnas.0407069102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Massimo Morra, Robert A. Barrington, Ana C. Abadia-Molina, Susumo Okamoto, Aimee Julien, Charles Gullo, Anuj Kalsy, Matthew J. Edwards, Gang Chen, Rosanne Spolski, Warren J. Leonard, Brigitte T. Huber, Persephone Borrow, Christine A. Biron, Abhay R. Satoskar, Michael C. Carroll, and Cox Terhorst

Defective B cell responses in the absence of SH2D1A
PNAS 2005 102: 4819-4823; published online before print March 17 2005, 10.1073/pnas.0408681102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Pablo A. González, Leandro J. Carreño, Daniel Coombs, Jorge E. Mora, Edith Palmieri, Byron Goldstein, Stanley G. Nathenson, and Alexis M. Kalergis

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell
PNAS 2005 102: 4824-4829; published online before print March 16 2005, 10.1073/pnas.0500922102 [Abstract] [Full Text] [Figures Only] [PDF]  

Chun Kim, Nadesan Gajendran, Hans-Willi Mittrücker, Matthias Weiwad, Young-Hwa Song, Robert Hurwitz, Matthias Wilmanns, Gunter Fischer, and Stefan H. E. Kaufmann

Human -defensins neutralize anthrax lethal toxin and protect against its fatal consequences
PNAS 2005 102: 4830-4835; published online before print March 16 2005, 10.1073/pnas.0500508102 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Daniel P. Webster, Susanna Dunachie, Jenni M. Vuola, Tamara Berthoud, Sheila Keating, Stephen M. Laidlaw, Samuel J. McConkey, Ian Poulton, Laura Andrews, Rikke F. Andersen, Philip Bejon, Geoff Butcher, Robert Sinden, Michael A. Skinner, Sarah C. Gilbert, and Adrian V. S. Hill

Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara
PNAS 2005 102: 4836-4841; published online before print March 21 2005, 10.1073/pnas.0406381102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Chitra Subramanian, Anthony W. Opipari, Jr., Xin Bian, Valerie P. Castle, and Roland P. S. Kwok

Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors
PNAS 2005 102: 4842-4847; published online before print March 18 2005, 10.1073/pnas.0408351102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Richard Malley, Krzysztof Trzcinski, Amit Srivastava, Claudette M. Thompson, Porter W. Anderson, and Marc Lipsitch

CD4⁺ T cells mediate antibody-independent acquired immunity to pneumococcal colonization
PNAS 2005 102: 4848-4853; published online before print March 21 2005, 10.1073/pnas.0501254102 [Abstract] [Full Text] [Figures Only] [PDF]  

Katarzyna E. Kolodziejska, Alan R. Burns, Robert H. Moore, David L. Stenoien, and N. Tony Eissa

Regulation of inducible nitric oxide synthase by aggresome formation
PNAS 2005 102: 4854-4859; published online before print March 21 2005, 10.1073/pnas.0500485102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Microbiology

Largus T. Angenent, Scott T. Kelley, Allison St. Amand, Norman R. Pace, and Mark T. Hernandez

Molecular identification of potential pathogens in water and air of a hospital therapy pool
PNAS 2005 102: 4860-4865; published online before print March 15 2005, 10.1073/pnas.0501235102 [Abstract] [Full Text] [Figures Only] [PDF]  

Nadim Shohdy, Jem A. Efe, Scott D. Emr, and Howard A. Shuman

Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking
PNAS 2005 102: 4866-4871; published online before print March 21 2005, 10.1073/pnas.0501315102 [Abstract] [Full Text] [Figures Only] [PDF]  

Neuroscience

Martin Styner, Jeffrey A. Lieberman, Robert K. McClure, Daniel R. Weinberger, Douglas W. Jones, and Guido Gerig

Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors
PNAS 2005 102: 4872-4877; published online before print March 16 2005, 10.1073/pnas.0501117102 [Abstract] [Full Text] [Figures Only] [PDF]  

Iwona Stepniewska, Pei-Chun Fang, and Jon H. Kaas

Microstimulation reveals specialized subregions for different complex movements in posterior parietal cortex of prosimian galagos
PNAS 2005 102: 4878-4883; published online before print March 16 2005, 10.1073/pnas.0501048102 [Abstract] [Full Text] [Figures Only] [PDF]  

Thaddeus P. Dryja, Terri L. McGee, Eliot L. Berson, Gerald A. Fishman, Michael A. Sandberg, Kenneth R. Alexander, Deborah J. Derlacki, and Aruna S. Rajagopalan

Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6
PNAS 2005 102: 4884-4889; published online before print March 21 2005, 10.1073/pnas.0501233102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xing Zhao, Heather Lorenc, Heather Stephenson, Yunjiao Joy Wang, Dawn Witherspoon, Benita Katzenellenbogen, Donald Pfaff, and Nandini Vasudevan

Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells
PNAS 2005 102: 4890-4895; published online before print March 18 2005, 10.1073/pnas.0501042102 [Abstract] [Full Text] [Figures Only] [PDF]  

Pharmacology

Filomena de Nigris, Sharon Williams-Ignarro, Lilach O. Lerman, Ettore Crimi, Chiara Botti, Gelsomina Mansueto, Francesco P. D'Armiento, Gaetano De Rosa, Vincenzo Sica, Louis J. Ignarro, and Claudio Napoli

Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress
PNAS 2005 102: 4896-4901; published online before print March 21 2005, 10.1073/pnas.0500998102 [Abstract] [Full Text] [Figures Only] [PDF]  

Plant Biology

Marci Surpin, Marcela Rojas-Pierce, Clay Carter, Glenn R. Hicks, Jacob Vasquez, and Natasha V. Raikhel

The power of chemical genomics to study the link between endomembrane system components and the gravitropic response
PNAS 2005 102: 4902-4907; published online before print March 16 2005, 10.1073/pnas.0500222102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jana Hackbusch, Klaus Richter, Judith Müller, Francesco Salamini, and Joachim F. Uhrig

A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins
PNAS 2005 102: 4908-4912; published online before print March 21 2005, 10.1073/pnas.0501181102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Pierre Joliot and Anne Joliot

Quantification of cyclic and linear flows in plants
PNAS 2005 102: 4913-4918; published online before print March 21 2005, 10.1073/pnas.0501268102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]