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Table of Contents

May 10, 2005; 102 (19)  [Index By Author]  [Cover Photo]  [Masthead (PDF)]

FROM THE COVER

Free energy profiles probe reaction mechanisms

Myosin motor's recovery stroke

Eukaryotic bacteriorhodopsin-like pump

Polyclonal origin of intestinal adenomas

Cold suppresses chestnut circadian clock

IN THIS ISSUE

COMMENTARIES

SPECIAL FEATURE
    Introduction

PERSPECTIVES

PHYSICAL SCIENCES
    Chemistry
    Computer Sciences
    Mathematics
    Physics

SOCIAL SCIENCES
    Anthropology
    Social Sciences

BIOLOGICAL SCIENCES
    Applied Biological Sciences
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Physiology
    Plant Biology

CORRECTIONS

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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 6637-6638. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

Ivan Rodriguez
Remarkable diversity of mammalian pheromone receptor repertoires
PNAS 2005 102: 6639-6640; published online before print May 3 2005, 10.1073/pnas.0502318102 [Extract] [Full Text] [Figures Only] [PDF]  

SPECIAL FEATURE

Introduction

Bruce J. Berne
Chemical Theory and Computation Special Feature: Chemical theory and computation
PNAS 2005 102: 6647; published online before print May 3 2005, 10.1073/pnas.0503208102 [Extract] [Full Text] [PDF]  

PERSPECTIVES

Edward Coe and Lee B. Kass
Proof of physical exchange of genes on the chromosomes
PNAS 2005 102: 6641-6646; published online before print May 2 2005, 10.1073/pnas.0407340102 [Abstract] [Full Text] [Figures Only] [PDF]  

Richard A. Friesner
Chemical Theory and Computation Special Feature: Ab initio quantum chemistry: Methodology and applications
PNAS 2005 102: 6648-6653; published online before print May 3 2005, 10.1073/pnas.0408036102 [Abstract] [Full Text] [PDF]  

Radu Iftimie, Peter Minary, and Mark E. Tuckerman
Chemical Theory and Computation Special Feature: Ab initio molecular dynamics: Concepts, recent developments, and future trends
PNAS 2005 102: 6654-6659; published online before print May 3 2005, 10.1073/pnas.0500193102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

William H. Miller
Chemical Theory and Computation Special Feature: Quantum dynamics of complex molecular systems
PNAS 2005 102: 6660-6664; published online before print May 3 2005, 10.1073/pnas.0408043102 [Abstract] [Full Text] [Figures Only] [PDF]  

William L. Jorgensen and Julian Tirado-Rives
Chemical Theory and Computation Special Feature: Potential energy functions for atomic-level simulations of water and organic and biomolecular systems
PNAS 2005 102: 6665-6670; published online before print May 3 2005, 10.1073/pnas.0408037102 [Abstract] [Full Text] [Figures Only] [PDF]  

Uzi Landman
Chemical Theory and Computation Special Feature: Materials by numbers: Computations as tools of discovery
PNAS 2005 102: 6671-6678; published online before print May 3 2005, 10.1073/pnas.0408038102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

M. Karplus and J. Kuriyan
Chemical Theory and Computation Special Feature: Molecular dynamics and protein function
PNAS 2005 102: 6679-6685; published online before print May 3 2005, 10.1073/pnas.0408930102 [Abstract] [Full Text] [Figures Only] [PDF]  

Hans C. Andersen
Chemical Theory and Computation Special Feature: Molecular dynamics studies of heterogeneous dynamics and dynamic crossover in supercooled atomic liquids
PNAS 2005 102: 6686-6691; published online before print May 3 2005, 10.1073/pnas.0500946102 [Abstract] [Full Text] [PDF]  

PHYSICAL SCIENCES

Chemistry

Yousung Jung, Alex Sodt, Peter M. W. Gill, and Martin Head-Gordon
Chemical Theory and Computation Special Feature: Auxiliary basis expansions for large-scale electronic structure calculations
PNAS 2005 102: 6692-6697; published online before print April 21 2005, 10.1073/pnas.0408475102 [Abstract] [Full Text] [Figures Only] [PDF]  

Partha Pratim Bera and Henry F. Schaefer, III
Chemical Theory and Computation Special Feature: (G–H){bullet}–C and G–(C–H){bullet} radicals derived from the guanine·cytosine base pair cause DNA subunit lesions
PNAS 2005 102: 6698-6703; published online before print April 6 2005, 10.1073/pnas.0408644102 [Abstract] [Full Text] [Figures Only] [PDF]  

D. Asthagiri, L. R. Pratt, and J. D. Kress
Chemical Theory and Computation Special Feature: Ab initio molecular dynamics and quasichemical study of H+(aq)
PNAS 2005 102: 6704-6708; published online before print April 14 2005, 10.1073/pnas.0408071102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jens Aage Poulsen, Gunnar Nyman, and Peter J. Rossky
Chemical Theory and Computation Special Feature: Static and dynamic quantum effects in molecular liquids: A linearized path integral description of water
PNAS 2005 102: 6709-6714; published online before print April 28 2005, 10.1073/pnas.0408647102 [Abstract] [Full Text] [Figures Only] [PDF]  

Sara Bonella, Daniel Montemayor, and David F. Coker
Chemical Theory and Computation Special Feature: Linearized path integral approach for calculating nonadiabatic time correlation functions
PNAS 2005 102: 6715-6719; published online before print April 4 2005, 10.1073/pnas.0408326102 [Abstract] [Full Text] [Figures Only] [PDF]  

C. P. Lawrence and J. L. Skinner
Chemical Theory and Computation Special Feature: Quantum corrections in vibrational and electronic condensed phase spectroscopy: Line shapes and echoes
PNAS 2005 102: 6720-6725; published online before print April 22 2005, 10.1073/pnas.0408813102 [Abstract] [Full Text] [Figures Only] [PDF]  

Robert B. Best and Gerhard Hummer
Chemical Theory and Computation Special Feature: Reaction coordinates and rates from transition paths
PNAS 2005 102: 6732-6737; published online before print April 6 2005, 10.1073/pnas.0408098102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Kyle J. Caspersen and Emily A. Carter
Chemical Theory and Computation Special Feature: Finding transition states for crystalline solid–solid phase transformations
PNAS 2005 102: 6738-6743; published online before print April 29 2005, 10.1073/pnas.0408127102 [Abstract] [Full Text] [Figures Only] [PDF]  

Arindam Chakraborty and Donald G. Truhlar
Chemical Theory and Computation Special Feature: Quantum mechanical reaction rate constants by vibrational configuration interaction: The OH + H2->H2O + H reaction as a function of temperature
PNAS 2005 102: 6744-6749; published online before print March 17 2005, 10.1073/pnas.0408048102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chris Oostenbrink and Wilfred F. van Gunsteren
Chemical Theory and Computation Special Feature: Free energies of ligand binding for structurally diverse compounds
PNAS 2005 102: 6750-6754; published online before print March 14 2005, 10.1073/pnas.0407404102 [Abstract] [Full Text] [Figures Only] [PDF]  

Bernd Ensing and Michael L. Klein
Chemical Theory and Computation Special Feature: Perspective on the reactions between F and CH3CH2F: The free energy landscape of the E2 and SN2 reaction channels
PNAS 2005 102: 6755-6759; published online before print April 29 2005, 10.1073/pnas.0408094102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hao Fan, Alan E. Mark, Jiang Zhu, and Barry Honig
Chemical Theory and Computation Special Feature: Comparative study of generalized Born models: Protein dynamics
PNAS 2005 102: 6760-6764; published online before print April 6 2005, 10.1073/pnas.0408857102 [Abstract] [Full Text] [PDF]  

Dietmar Paschek, S. Gnanakaran, and Angel E. Garcia
Chemical Theory and Computation Special Feature: Simulations of the pressure and temperature unfolding of an {alpha}-helical peptide
PNAS 2005 102: 6765-6770; published online before print March 30 2005, 10.1073/pnas.0408527102 [Abstract] [Full Text] [Figures Only] [PDF]  

Wonpil Im and Charles L. Brooks, III
Chemical Theory and Computation Special Feature: Interfacial folding and membrane insertion of designed peptides studied by molecular dynamics simulations
PNAS 2005 102: 6771-6776; published online before print April 28 2005, 10.1073/pnas.0408135102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tanya M. Raschke and Michael Levitt
Chemical Theory and Computation Special Feature: Nonpolar solutes enhance water structure within hydration shells while reducing interactions between them
PNAS 2005 102: 6777-6782; published online before print May 2 2005, 10.1073/pnas.0500225102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Elizabeth Villa, Alexander Balaeff, and Klaus Schulten
Chemical Theory and Computation Special Feature: Structural dynamics of the lac repressor–DNA complex revealed by a multiscale simulation
PNAS 2005 102: 6783-6788; published online before print April 29 2005, 10.1073/pnas.0409387102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Changbong Hyeon and D. Thirumalai
Chemical Theory and Computation Special Feature: Mechanical unfolding of RNA hairpins
PNAS 2005 102: 6789-6794; published online before print March 4 2005, 10.1073/pnas.0408314102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jiancong Xu and Gregory A. Voth
Chemical Theory and Computation Special Feature: Computer simulation of explicit proton translocation in cytochrome c oxidase: The D-pathway
PNAS 2005 102: 6795-6800; published online before print April 27 2005, 10.1073/pnas.0408117102 [Abstract] [Full Text] [Figures Only] [PDF]  

Michael Andrec, Anthony K. Felts, Emilio Gallicchio, and Ronald M. Levy
Chemical Theory and Computation Special Feature: Protein folding pathways from replica exchange simulations and a kinetic network model
PNAS 2005 102: 6801-6806; published online before print March 30 2005, 10.1073/pnas.0408970102 [Abstract] [Full Text] [Figures Only] [PDF]  

Kim F. Wong, Tzvia Selzer, Stephen J. Benkovic, and Sharon Hammes-Schiffer
Chemical Theory and Computation Special Feature: Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase
PNAS 2005 102: 6807-6812; published online before print April 5 2005, 10.1073/pnas.0408343102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Richard J. Law, Richard H. Henchman, and J. Andrew McCammon
Chemical Theory and Computation Special Feature: A gating mechanism proposed from a simulation of a human {alpha}7 nicotinic acetylcholine receptor
PNAS 2005 102: 6813-6818; published online before print April 27 2005, 10.1073/pnas.0407739102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Jan Florián, Myron F. Goodman, and Arieh Warshel
Chemical Theory and Computation Special Feature: Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
PNAS 2005 102: 6819-6824; published online before print April 29 2005, 10.1073/pnas.0408173102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hyung-June Woo and Benoît Roux
Chemical Theory and Computation Special Feature: Calculation of absolute protein–ligand binding free energy from computer simulations
PNAS 2005 102: 6825-6830; published online before print May 2 2005, 10.1073/pnas.0409005102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Guillaume Izzet, Bénédicte Douziech, Thierry Prangé, Alain Tomas, Ivan Jabin, Yves Le Mest, and Olivia Reinaud
Calix[6]tren and copper(II): A third generation of funnel complexes on the way to redox calix-zymes
PNAS 2005 102: 6831-6836; published online before print May 2 2005, 10.1073/pnas.0500240102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Computer Sciences

Ragini Verma, Susumu Mori, Dinggang Shen, Paul Yarowsky, Jiangyang Zhang, and Christos Davatzikos
Spatiotemporal maturation patterns of murine brain quantified by diffusion tensor MRI and deformation-based morphometry
PNAS 2005 102: 6978-6983; published online before print April 28 2005, 10.1073/pnas.0407828102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Mathematics

Z. Rudnick and K. Soundararajan
Lower bounds for moments of L-functions
PNAS 2005 102: 6837-6838; published online before print May 2 2005, 10.1073/pnas.0501723102 [Abstract] [Full Text] [PDF]  

Physics

Emily E. Meyer, Qi Lin, Tue Hassenkam, Emin Oroudjev, and Jacob N. Israelachvili
Origin of the long-range attraction between surfactant-coated surfaces
PNAS 2005 102: 6839-6842; published online before print April 29 2005, 10.1073/pnas.0502110102 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Anthropology

E. A. Hammel
Chayanov revisited: A model for the economics of complex kin units
PNAS 2005 102: 7043-7046; published online before print May 2 2005, 10.1073/pnas.0501987102 [Abstract] [Full Text] [Figures Only] [PDF]  

Social Sciences

James H. Fowler
Altruistic punishment and the origin of cooperation
PNAS 2005 102: 7047-7049; published online before print April 27 2005, 10.1073/pnas.0500938102 [Abstract] [Full Text] [Figures Only] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Juan P. Liuzzi, Louis A. Lichten, Seth Rivera, Raymond K. Blanchard, Tolunay Beker Aydemir, Mitchell D. Knutson, Tomas Ganz, and Robert J. Cousins
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
PNAS 2005 102: 6843-6848; published online before print April 29 2005, 10.1073/pnas.0502257102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

Valerie Calabro, Matthew D. Daugherty, and Alan D. Frankel
A single intermolecular contact mediates intramolecular stabilization of both RNA and protein
PNAS 2005 102: 6849-6854; published online before print April 27 2005, 10.1073/pnas.0409282102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Navin Varadarajan, Jongsik Gam, Mark J. Olsen, George Georgiou, and Brent L. Iverson
Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity
PNAS 2005 102: 6855-6860; published online before print May 2 2005, 10.1073/pnas.0500063102 [Abstract] [Full Text] [Figures Only] [PDF]  

Wei Feng, Jia-fu Long, and Mingjie Zhang
A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins
PNAS 2005 102: 6861-6866; published online before print April 29 2005, 10.1073/pnas.0409346102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kevin V. Kepple, Jeffrey L. Boldt, and Anca M. Segall
Holliday junction-binding peptides inhibit distinct junction-processing enzymes
PNAS 2005 102: 6867-6872; published online before print May 2 2005, 10.1073/pnas.0409496102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Hiroshi Fujisaki and John E. Straub
Chemical Theory and Computation Special Feature: Vibrational energy relaxation in proteins
PNAS 2005 102: 6726-6731; published online before print March 14 2005, 10.1073/pnas.0409083102 [Abstract] [Full Text] [Figures Only] [PDF]  

Hao Fan, Alan E. Mark, Jiang Zhu, and Barry Honig
Chemical Theory and Computation Special Feature: Comparative study of generalized Born models: Protein dynamics
PNAS 2005 102: 6760-6764; published online before print April 6 2005, 10.1073/pnas.0408857102 [Abstract] [Full Text] [PDF]  

Dietmar Paschek, S. Gnanakaran, and Angel E. Garcia
Chemical Theory and Computation Special Feature: Simulations of the pressure and temperature unfolding of an {alpha}-helical peptide
PNAS 2005 102: 6765-6770; published online before print March 30 2005, 10.1073/pnas.0408527102 [Abstract] [Full Text] [Figures Only] [PDF]  

Elizabeth Villa, Alexander Balaeff, and Klaus Schulten
Chemical Theory and Computation Special Feature: Structural dynamics of the lac repressor–DNA complex revealed by a multiscale simulation
PNAS 2005 102: 6783-6788; published online before print April 29 2005, 10.1073/pnas.0409387102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael Andrec, Anthony K. Felts, Emilio Gallicchio, and Ronald M. Levy
Chemical Theory and Computation Special Feature: Protein folding pathways from replica exchange simulations and a kinetic network model
PNAS 2005 102: 6801-6806; published online before print March 30 2005, 10.1073/pnas.0408970102 [Abstract] [Full Text] [Figures Only] [PDF]  

Richard J. Law, Richard H. Henchman, and J. Andrew McCammon
Chemical Theory and Computation Special Feature: A gating mechanism proposed from a simulation of a human {alpha}7 nicotinic acetylcholine receptor
PNAS 2005 102: 6813-6818; published online before print April 27 2005, 10.1073/pnas.0407739102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Stefan Fischer, Björn Windshügel, Daniel Horak, Kenneth C. Holmes, and Jeremy C. Smith
From the Cover: Structural mechanism of the recovery stroke in the Myosin molecular motor
PNAS 2005 102: 6873-6878; published online before print April 29 2005, 10.1073/pnas.0408784102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

Stephen A. Waschuk, Arandi G. Bezerra, Jr., Lichi Shi, and Leonid S. Brown
From the Cover: Leptosphaeria rhodopsin: Bacteriorhodopsin-like proton pump from a eukaryote
PNAS 2005 102: 6879-6883; published online before print April 28 2005, 10.1073/pnas.0409659102 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Jingsong Xu, Fei Wang, Alexandra Van Keymeulen, Maike Rentel, and Henry R. Bourne
Neutrophil microtubules suppress polarity and enhance directional migration
PNAS 2005 102: 6884-6889; published online before print April 28 2005, 10.1073/pnas.0502106102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Developmental Biology

Anxo Vidal, Stergios Zacharoulis, Wenjun Guo, David Shaffer, Filippo Giancotti, Anna H. Bramley, Carmen de la Hoz, Kristian K. Jensen, Daniel Kato, Daniel D. MacDonald, Joseph Knowles, Nancy Yeh, Lawrence A. Frohman, Shahin Rafii, David Lyden, and Andrew Koff
p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow
PNAS 2005 102: 6890-6895; published online before print May 2 2005, 10.1073/pnas.0405823102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Genetics

Robert D. Schnabel, Jong-Joo Kim, Melissa S. Ashwell, Tad S. Sonstegard, Curtis P. Van Tassell, Erin E. Connor, and Jeremy F. Taylor
Fine-mapping milk production quantitative trait loci on BTA6: Analysis of the bovine osteopontin gene
PNAS 2005 102: 6896-6901; published online before print May 2 2005, 10.1073/pnas.0502398102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

D. Remondini, B. O'Connell, N. Intrator, J. M. Sedivy, N. Neretti, G. C. Castellani, and L. N. Cooper
Targeting c-Myc-activated genes with a correlation method: Detection of global changes in large gene expression network dynamics
PNAS 2005 102: 6902-6906; published online before print May 2 2005, 10.1073/pnas.0502081102 [Abstract] [Full Text] [Figures Only] [PDF]  

Thomas Clouaire, Myriam Roussigne, Vincent Ecochard, Catherine Mathe, François Amalric, and Jean-Philippe Girard
The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity
PNAS 2005 102: 6907-6912; published online before print April 29 2005, 10.1073/pnas.0406882102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Vanessa Khemici, Leonora Poljak, Isabelle Toesca, and Agamemnon J. Carpousis
Evidence in vivo that the DEAD-box RNA helicase RhlB facilitates the degradation of ribosome-free mRNA by RNase E
PNAS 2005 102: 6913-6918; published online before print May 2 2005, 10.1073/pnas.0501129102 [Abstract] [Full Text] [Figures Only] [PDF]  

Immunology

John D. Hansen, Eric D. Landis, and Ruth B. Phillips
Discovery of a unique Ig heavy-chain isotype (IgT) in rainbow trout: Implications for a distinctive B cell developmental pathway in teleost fish
PNAS 2005 102: 6919-6924; published online before print April 29 2005, 10.1073/pnas.0500027102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ekambar R. Kandimalla, Lakshmi Bhagat, Yukui Li, Dong Yu, Daqing Wang, Yan-Ping Cong, Sam S. Song, Jimmy X. Tang, Tim Sullivan, and Sudhir Agrawal
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists
PNAS 2005 102: 6925-6930; published online before print April 28 2005, 10.1073/pnas.0501729102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anja Jaeschke, Mercedes Rincón, Beth Doran, Judith Reilly, Donna Neuberg, Dale L. Greiner, Leonard D. Shultz, Aldo A. Rossini, Richard A. Flavell, and Roger J. Davis
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes
PNAS 2005 102: 6931-6935; published online before print May 2 2005, 10.1073/pnas.0502143102 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Deyin Xing and Sandra Orsulic
A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance
PNAS 2005 102: 6936-6941; published online before print April 28 2005, 10.1073/pnas.0502256102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Li Xin, Devon A. Lawson, and Owen N. Witte
The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis
PNAS 2005 102: 6942-6947; published online before print April 28 2005, 10.1073/pnas.0502320102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Qian Zhang, Hong Y. Wang, Michal Marzec, Puthiyaveettil N. Raghunath, Tomohiko Nagasawa, and Mariusz A. Wasik
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
PNAS 2005 102: 6948-6953; published online before print May 3 2005, 10.1073/pnas.0501959102 [Abstract] [Full Text] [Figures Only] [PDF]  

Yunxia Tao, Jun Kim, Sarah Faubel, Joe C. Wu, Sandor A. Falk, Robert W. Schrier, and Charles L. Edelstein
Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease
PNAS 2005 102: 6954-6959; published online before print April 29 2005, 10.1073/pnas.0408518102 [Abstract] [Full Text] [Figures Only] [PDF]  

Andrew T. Thliveris, Richard B. Halberg, Linda Clipson, William F. Dove, Ruth Sullivan, Mary Kay Washington, Stephen Stanhope, and Michael A. Newton
From the Cover: Polyclonality of familial murine adenomas: Analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions
PNAS 2005 102: 6960-6965; published online before print May 3 2005, 10.1073/pnas.0502662102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Methods]  

Biao Lei, Ken Matsuo, Volodymyr Labinskyy, Naveen Sharma, Margaret P. Chandler, Anna Ahn, Thomas H. Hintze, William C. Stanley, and Fabio A. Recchia
Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo
PNAS 2005 102: 6966-6971; published online before print May 3 2005, 10.1073/pnas.0500768102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Andrew T. Revel, Jon S. Blevins, Consuelo Almazán, Lori Neil, Katherine M. Kocan, José de la Fuente, Kayla E. Hagman, and Michael V. Norgard
bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector
PNAS 2005 102: 6972-6977; published online before print April 28 2005, 10.1073/pnas.0502565102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Ragini Verma, Susumu Mori, Dinggang Shen, Paul Yarowsky, Jiangyang Zhang, and Christos Davatzikos
Spatiotemporal maturation patterns of murine brain quantified by diffusion tensor MRI and deformation-based morphometry
PNAS 2005 102: 6978-6983; published online before print April 28 2005, 10.1073/pnas.0407828102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ignacio Lopez-Coviella, Maximillian T. Follettie, Tiffany J. Mellott, Vesela P. Kovacheva, Barbara E. Slack, Veronica Diesl, Brygida Berse, R. Scott Thies, and Jan Krzysztof Blusztajn
Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons
PNAS 2005 102: 6984-6989; published online before print May 3 2005, 10.1073/pnas.0502097102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table] OPEN ACCESS ARTICLE  

Wendy Noble, Emmanuel Planel, Cindy Zehr, Vicki Olm, Jordana Meyerson, Farhana Suleman, Kate Gaynor, Lili Wang, John LaFrancois, Boris Feinstein, Mark Burns, Pavan Krishnamurthy, Yi Wen, Ratan Bhat, Jada Lewis, Dennis Dickson, and Karen Duff
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
PNAS 2005 102: 6990-6995; published online before print May 2 2005, 10.1073/pnas.0500466102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Mark A. Pinsk, Kevin DeSimone, Tirin Moore, Charles G. Gross, and Sabine Kastner
Representations of faces and body parts in macaque temporal cortex: A functional MRI study
PNAS 2005 102: 6996-7001; published online before print April 28 2005, 10.1073/pnas.0502605102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Christoph Börgers, Steven Epstein, and Nancy J. Kopell
Background gamma rhythmicity and attention in cortical local circuits: A computational study
PNAS 2005 102: 7002-7007; published online before print May 3 2005, 10.1073/pnas.0502366102 [Abstract] [Full Text] [Figures Only] [PDF]  

Pharmacology

Tudor M. Griffith, Andrew T. Chaytor, Linda M. Bakker, and David H. Edwards
5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation
PNAS 2005 102: 7008-7013; published online before print May 2 2005, 10.1073/pnas.0408919102 [Abstract] [Full Text] [Figures Only] [PDF]  

Physiology

Barry G. Timms, Kembra L. Howdeshell, Lesley Barton, Sarahann Bradley, Catherine A. Richter, and Frederick S. vom Saal
Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra
PNAS 2005 102: 7014-7019; published online before print May 2 2005, 10.1073/pnas.0502544102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Plant Biology

Mitsunori Hayashi, Hideyuki Takahashi, Katsunori Tamura, Jirong Huang, Li-Hua Yu, Maki Kawai-Yamada, Takafumi Tezuka, and Hirofumi Uchimiya
Enhanced dihydroflavonol-4-reductase activity and NAD homeostasis leading to cell death tolerance in transgenic rice
PNAS 2005 102: 7020-7025; published online before print April 29 2005, 10.1073/pnas.0502556102 [Abstract] [Full Text] [Figures Only] [PDF]  

Kisung Ko, Zenon Steplewski, Magdalena Glogowska, and Hilary Koprowski
Inhibition of tumor growth by plant-derived mAb
PNAS 2005 102: 7026-7030; published online before print May 2 2005, 10.1073/pnas.0502533102 [Abstract] [Full Text] [Figures Only] [PDF]  

Giovanni Finazzi, Frederik Sommer, and Michael Hippler
Release of oxidized plastocyanin from photosystem I limits electron transfer between photosystem I and cytochrome b6f complex in vivo
PNAS 2005 102: 7031-7036; published online before print May 3 2005, 10.1073/pnas.0406288102 [Abstract] [Full Text] [Figures Only] [PDF]  

Alberto Ramos, Estefanía Pérez-Solís, Cristian Ibáñez, Rosa Casado, Carmen Collada, Luis Gómez, Cipriano Aragoncillo, and Isabel Allona
From the Cover: Winter disruption of the circadian clock in chestnut
PNAS 2005 102: 7037-7042; published online before print April 28 2005, 10.1073/pnas.0408549102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

CORRECTIONS

Correction for Zhang et al., A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1, PNAS 2005 102:4536-4541 [Extract] [Full Text] [PDF]  

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