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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 251-252. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

Todd D. Gould and Husseini K. Manji

DARPP-32: A molecular switch at the nexus of reward pathway plasticity
PNAS 2005 102: 253-254; published online before print January 4 2005, 10.1073/pnas.0408700102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 491

PHYSICAL SCIENCES

Chemistry

Anton F. Fliri, William T. Loging, Peter F. Thadeio, and Robert A. Volkmann Biological spectra analysis: Linking biological activity profiles to molecular structure PNAS 2005 102: 261-266; published online before print December 29 2004, 10.1073/pnas.0407790101 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Data Sets] OPEN ACCESS ARTICLE

Xiaoxia Sheng, Taesung Jung, Jeffrey A. Wesson, and Michael D. Ward From The Cover: Adhesion at calcium oxalate crystal surfaces and the effect of urinary constituents PNAS 2005 102: 267-272; published online before print December 29 2004, 10.1073/pnas.0406835101 [Abstract] [Full Text] [Figures Only] [PDF]

Gerhard Schenk, Lawrence R. Gahan, Lyle E. Carrington, Natasa Mitic, Mohsen Valizadeh, Susan E. Hamilton, John de Jersey, and Luke W. Guddat

Phosphate forms an unusual tripodal complex with the Fe–Mn center of sweet potato purple acid phosphatase
PNAS 2005 102: 273-278; published online before print December 29 2004, 10.1073/pnas.0407239102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Indrajit Roy, Tymish Y. Ohulchanskyy, Dhruba J. Bharali, Haridas E. Pudavar, Ruth A. Mistretta, Navjot Kaur, and Paras N. Prasad

Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery
PNAS 2005 102: 279-284; published online before print January 3 2005, 10.1073/pnas.0408039101 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

BIOLOGICAL SCIENCES

Applied Biological Sciences

Indrajit Roy, Tymish Y. Ohulchanskyy, Dhruba J. Bharali, Haridas E. Pudavar, Ruth A. Mistretta, Navjot Kaur, and Paras N. Prasad

Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery
PNAS 2005 102: 279-284; published online before print January 3 2005, 10.1073/pnas.0408039101 [Abstract] [Full Text] [Figures Only] [PDF]  

Biochemistry

Caroline A. Davis, Michael W. Capp, M. Thomas Record, Jr, and Ruth M. Saecker

The effects of upstream DNA on open complex formation by Escherichia coli RNA polymerase
PNAS 2005 102: 285-290; published online before print December 30 2004, 10.1073/pnas.0405779102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Wilma Ross and Richard L. Gourse

Sequence-independent upstream DNA–CTD interactions strongly stimulate Escherichia coli RNA polymerase-lacUV5 promoter association
PNAS 2005 102: 291-296; published online before print December 30 2004, 10.1073/pnas.0405814102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Michael L. Oldham, Alan R. Brash, and Marcia E. Newcomer

The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide
PNAS 2005 102: 297-302; published online before print December 29 2004, 10.1073/pnas.0406352102 [Abstract] [Full Text] [Figures Only] [PDF]  

Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su

The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus
PNAS 2005 102: 303-308; published online before print January 3 2005, 10.1073/pnas.0407459102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gunnar F. Kaufmann, Rafaella Sartorio, Sang-Hyeup Lee, Claude J. Rogers, Michael M. Meijler, Jason A. Moss, Bruce Clapham, Andrew P. Brogan, Tobin J. Dickerson, and Kim D. Janda

Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones
PNAS 2005 102: 309-314; published online before print December 27 2004, 10.1073/pnas.0408639102 [Abstract] [Full Text] [Figures Only] [PDF]  

Biophysics

O. Sumner Makin, Edward Atkins, Pawel Sikorski, Jan Johansson, and Louise C. Serpell

Molecular basis for amyloid fibril formation and stability
PNAS 2005 102: 315-320; published online before print January 3 2005, 10.1073/pnas.0406847102 [Abstract] [Full Text] [Figures Only] [PDF]  

Daniel B. Forger and Charles S. Peskin

Stochastic simulation of the mammalian circadian clock
PNAS 2005 102: 321-324; published online before print December 30 2004, 10.1073/pnas.0408465102 [Abstract] [Full Text] [Figures Only] [PDF]  

M. C. Göpfert, A. D. L. Humphris, J. T. Albert, D. Robert, and O. Hendrich

Power gain exhibited by motile mechanosensory neurons in Drosophila ears
PNAS 2005 102: 325-330; published online before print December 28 2004, 10.1073/pnas.0405741102 [Abstract] [Full Text] [Figures Only] [PDF]  

Tatsuo Shibata and Koichi Fujimoto

Noisy signal amplification in ultrasensitive signal transduction
PNAS 2005 102: 331-336; published online before print December 29 2004, 10.1073/pnas.0403350102 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Changjun Zhu and Wei Jiang

Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis
PNAS 2005 102: 343-348; published online before print December 29 2004, 10.1073/pnas.0408438102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mira Sastri, David M. Barraclough, Peter T. Carmichael, and Susan S. Taylor

A-kinase-interacting protein localizes protein kinase A in the nucleus
PNAS 2005 102: 349-354; published online before print January 3 2005, 10.1073/pnas.0408608102 [Abstract] [Full Text] [Figures Only] [PDF]  

Chloe C. Feral, Naoyuki Nishiya, Csilla A. Fenczik, Heidi Stuhlmann, Marina Slepak, and Mark H. Ginsberg

CD98hc (SLC3A2) mediates integrin signaling
PNAS 2005 102: 355-360; published online before print December 29 2004, 10.1073/pnas.0404852102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Developmental Biology

Atsuo Kawahara, Yong-Suk Che, Ryuki Hanaoka, Hiroyuki Takeda, and Igor B. Dawid

Zebrafish GADD45 genes are involved in somite segmentation
PNAS 2005 102: 361-366; published online before print December 27 2004, 10.1073/pnas.0408726102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Emre Seli, Maria D. Lalioti, Sean M. Flaherty, Denny Sakkas, Nihal Terzi, and Joan A. Steitz

An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos
PNAS 2005 102: 367-372; published online before print January 3 2005, 10.1073/pnas.0408378102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Evolution

Laura A. Shackelton, Colin R. Parrish, Uwe Truyen, and Edward C. Holmes

High rate of viral evolution associated with the emergence of carnivore parvovirus
PNAS 2005 102: 379-384; published online before print December 30 2004, 10.1073/pnas.0406765102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

W. R. Hansen and K. Autumn

Evidence for self-cleaning in gecko setae
PNAS 2005 102: 385-389; published online before print January 3 2005, 10.1073/pnas.0408304102 [Abstract] [Full Text] [Figures Only] [PDF]  

Joel L. Sachs and James J. Bull

Experimental evolution of conflict mediation between genomes
PNAS 2005 102: 390-395; published online before print January 3 2005, 10.1073/pnas.0405738102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Genetics

Sudhir Perincheri, R. W. Cameron Dingle, Martha L. Peterson, and Brett T. Spear

Hereditary persistence of -fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene
PNAS 2005 102: 396-401; published online before print December 30 2004, 10.1073/pnas.0408555102 [Abstract] [Full Text] [Figures Only] [PDF]  

Nadège Minois, Magdalena Frajnt, Chris Wilson, and James W. Vaupel

Advances in measuring lifespan in the yeast Saccharomyces cerevisiae
PNAS 2005 102: 402-406; published online before print December 29 2004, 10.1073/pnas.0408332102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Stéphane Berghmans, Ryan D. Murphey, Erno Wienholds, Donna Neuberg, Jeffery L. Kutok, Christopher D. M. Fletcher, John P. Morris, Ting Xi Liu, Stefan Schulte-Merker, John P. Kanki, Ronald Plasterk, Leonard I. Zon, and A. Thomas Look

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
PNAS 2005 102: 407-412; published online before print January 3 2005, 10.1073/pnas.0406252102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Regina Tugyi, Katalin Uray, Dóra Iván, Erzsébet Fellinger, Alan Perkins, and Ferenc Hudecz

Partial D-amino acid substitution: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide
PNAS 2005 102: 413-418; published online before print January 3 2005, 10.1073/pnas.0407677102 [Abstract] [Full Text] [Figures Only] [PDF]  

Mei-Ling Chen, Mikaël J. Pittet, Leonid Gorelik, Richard A. Flavell, Ralph Weissleder, Harald von Boehmer, and Khashayarsha Khazaie

Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF- signals in vivo
PNAS 2005 102: 419-424; published online before print December 27 2004, 10.1073/pnas.0408197102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Medical Sciences

David R. Enis, Benjamin R. Shepherd, Yinong Wang, Asif Qasim, Catherine M. Shanahan, Peter L. Weissberg, Michael Kashgarian, Jordan S. Pober, and Jeffrey S. Schechner

Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells
PNAS 2005 102: 425-430; published online before print December 29 2004, 10.1073/pnas.0408357102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Denise Lau, Hanke Mollnau, Jason P. Eiserich, Bruce A. Freeman, Andreas Daiber, Ursula M. Gehling, Jens Brümmer, Volker Rudolph, Thomas Münzel, Thomas Heitzer, Thomas Meinertz, and Stephan Baldus

Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins
PNAS 2005 102: 431-436; published online before print December 29 2004, 10.1073/pnas.0405193102 [Abstract] [Full Text] [Figures Only] [PDF]  

James S. Swaney, David M. Roth, Erik R. Olson, Jennifer E. Naugle, J. Gary Meszaros, and Paul A. Insel

Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase
PNAS 2005 102: 437-442; published online before print December 29 2004, 10.1073/pnas.0408704102 [Abstract] [Full Text] [Figures Only] [PDF]  

Robert Pawlak, Jerry P. Melchor, Tomasz Matys, Anna E. Skrzypiec, and Sidney Strickland From The Cover: Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors PNAS 2005 102: 443-448; published online before print January 3 2005, 10.1073/pnas.0406454102 [Abstract] [Full Text] [Figures Only] [PDF]

Claus Meyer, Bjoern Schneider, Martin Reichel, Sieglinde Angermueller, Sabine Strehl, Susanne Schnittger, Claudia Schoch, Mieke W. J. C. Jansen, Jacques J. van Dongen, Rob Pieters, Oskar A. Haas, Theo Dingermann, Thomas Klingebiel, and Rolf Marschalek

Diagnostic tool for the identification of MLL rearrangements including unknown partner genes
PNAS 2005 102: 449-454; published online before print December 30 2004, 10.1073/pnas.0406994102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Allan L. Berger, Mutsuhiro Ikuma, and Michael J. Welsh

Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain
PNAS 2005 102: 455-460; published online before print December 27 2004, 10.1073/pnas.0408575102 [Abstract] [Full Text] [Figures Only] [PDF]  

Microbiology

Kyu Y. Rhee, Hediye Erdjument-Bromage, Paul Tempst, and Carl F. Nathan

S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense
PNAS 2005 102: 467-472; published online before print December 30 2004, 10.1073/pnas.0406133102 [Abstract] [Full Text] [Figures Only] [PDF]  

Neuroscience

Maureen P. Boyle, Judson A. Brewer, Michiyo Funatsu, David F. Wozniak, Joe Z. Tsien, Yukitoshi Izumi, and Louis J. Muglia

Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
PNAS 2005 102: 473-478; published online before print December 27 2004, 10.1073/pnas.0406458102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Eva Syková, Ivan Vorísek, Tatiana Antonova, Tomás Mazel, Melanie Meyer-Luehmann, Mathias Jucker, Milan Hájek, Michael Ort, and Jan Bures

Changes in extracellular space size and geometry in APP23 transgenic mice: A model of Alzheimer's disease
PNAS 2005 102: 479-484; published online before print January 3 2005, 10.1073/pnas.0408235102 [Abstract] [Full Text] [Figures Only] [PDF]  

Wim Vandenberghe, Roger A. Nicoll, and David S. Bredt

Stargazin is an AMPA receptor auxiliary subunit
PNAS 2005 102: 485-490; published online before print January 3 2005, 10.1073/pnas.0408269102 [Abstract] [Full Text] [Figures Only] [PDF]  

Emmanuel Valjent, Vincent Pascoli, Per Svenningsson, Surojit Paul, Hervé Enslen, Jean-Christophe Corvol, Alexandre Stipanovich, Jocelyne Caboche, Paul J. Lombroso, Angus C. Nairn, Paul Greengard, Denis Hervé, and Jean-Antoine Girault From The Cover: Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum PNAS 2005 102: 491-496; published online before print December 17 2004, 10.1073/pnas.0408305102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 253

Pharmacology

Andrew T. Bender, Cari L. Ostenson, Edith H. Wang, and Joseph A. Beavo

Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation
PNAS 2005 102: 497-502; published online before print December 29 2004, 10.1073/pnas.0408535102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Physiology

Qi Cai, Natalia I. Dmitrieva, Joan D. Ferraris, Heddwen L. Brooks, Bas W. M. van Balkom, and Maurice Burg

Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance
PNAS 2005 102: 503-508; published online before print December 27 2004, 10.1073/pnas.0408840102 [Abstract] [Full Text] [Figures Only] [PDF]  

Plant Biology

Neeti Sanan-Mishra, Xuan Hoi Pham, Sudhir K. Sopory, and Narendra Tuteja

Pea DNA helicase 45 overexpression in tobacco confers high salinity tolerance without affecting yield
PNAS 2005 102: 509-514; published online before print January 3 2005, 10.1073/pnas.0406485102 [Abstract] [Full Text] [Figures Only] [PDF]  

CORRECTIONS

Correction for Liu et al., From the Cover: AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase, PNAS 2004 101:13903-13908 [Extract] [Full Text] [Figures Only] [PDF]  

Correction for Laforsch et al., An acoustic microscopy technique reveals hidden morphological defenses in Daphnia, PNAS 2004 101:15911-15914 [Extract] [Full Text] [PDF]  

Correction for Marians et al., Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice, PNAS 2002 99:15776-15781 [Extract] [Full Text] [Figures Only] [PDF]  

Retraction for Grand et al., Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue, PNAS 2004 101:6140-6145 [Extract] [Full Text] [PDF]  

Retraction for Geraghty et al., Detecting patterns of protein distribution and gene expression in silico, PNAS 1999 96:2937-2942 [Extract] [Full Text] [PDF]