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Table of Contents

July 12, 2005; 102 (28)  [Index By Author]  [Cover Photo]  [Masthead (PDF)]

FROM THE COVER

Antifungal drug and mammalian microtubules

Yeast aromatic amino acid synthesis

Identifying heterocyst formation trigger

Neuropeptide B inhibits inflammatory pain

IN THIS ISSUE

FROM THE ACADEMY

COMMENTARIES

PHYSICAL SCIENCES
    Chemistry
    Engineering
    Geophysics

SOCIAL SCIENCES
    Social Sciences

BIOLOGICAL SCIENCES
    Biochemistry
    Biophysics
    Cell Biology
    Ecology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Physiology
    Plant Biology
    Psychology

CORRECTIONS

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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 9735-9736. [Full Text] [Figures Only] [PDF]  

FROM THE ACADEMY

Bruce Alberts
Editorial: Modeling attacks on the food supply
PNAS 2005 102: 9737-9738; published online before print June 28 2005, 10.1073/pnas.0504944102 [Extract] [Full Text] [PDF]  

COMMENTARIES

Ralf Bartenschlager and Thomas Pietschmann
Efficient hepatitis C virus cell culture system: What a difference the host cell makes
PNAS 2005 102: 9739-9740; published online before print July 5 2005, 10.1073/pnas.0504296102 [Extract] [Full Text] [PDF]  
See companion article on page 9294 in issue 26 of volume 102

PHYSICAL SCIENCES

Chemistry

Thomas A. Scott, Curtis P. Berlinguette, Richard H. Holm, and Hong-Cai Zhou
Initial synthesis and structure of an all-ferrous analogue of the fully reduced [Fe4S4]0 cluster of the nitrogenase iron protein
PNAS 2005 102: 9741-9744; published online before print June 28 2005, 10.1073/pnas.0504258102 [Abstract] [Full Text] [Figures Only] [PDF]  

Marcel O. Vlad, Stefan E. Szedlacsek, Nader Pourmand, L. Luca Cavalli-Sforza, Peter Oefner, and John Ross
Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics
PNAS 2005 102: 9848-9853; published online before print June 30 2005, 10.1073/pnas.0504073102 [Abstract] [Full Text] [PDF]  

Engineering

Kashan A. Shaikh, Kee Suk Ryu, Edgar D. Goluch, Jwa-Min Nam, Juewen Liu, C. Shad Thaxton, Thomas N. Chiesl, Annelise E. Barron, Yi Lu, Chad A. Mirkin, and Chang Liu
A modular microfluidic architecture for integrated biochemical analysis
PNAS 2005 102: 9745-9750; published online before print June 28 2005, 10.1073/pnas.0504082102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movie] OPEN ACCESS ARTICLE  

Geophysics

Wendy L. Mao, Yue Meng, Guoyin Shen, Vitali B. Prakapenka, Andrew J. Campbell, Dion L. Heinz, Jinfu Shu, Razvan Caracas, Ronald E. Cohen, Yingwei Fei, Russell J. Hemley, and Ho-kwang Mao
Iron-rich silicates in the Earth's D'' layer
PNAS 2005 102: 9751-9753; published online before print June 30 2005, 10.1073/pnas.0503737102 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Social Sciences

Lawrence M. Wein and Yifan Liu
Analyzing a bioterror attack on the food supply: The case of botulinum toxin in milk
PNAS 2005 102: 9984-9989; published online before print June 28 2005, 10.1073/pnas.0408526102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

BIOLOGICAL SCIENCES

Biochemistry

Mikael J. Lindberg, Roberth Byström, Niklas Boknäs, Peter M. Andersen, and Mikael Oliveberg
Systematically perturbed folding patterns of amyotrophic lateral sclerosis (ALS)-associated SOD1 mutants
PNAS 2005 102: 9754-9759; published online before print June 29 2005, 10.1073/pnas.0501957102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anna B. Gilg, Jeremy C. Bearfield, Claus Tittiger, William H. Welch, and Gary J. Blomquist
Isolation and functional expression of an animal geranyl diphosphate synthase and its role in bark beetle pheromone biosynthesis
PNAS 2005 102: 9760-9765; published online before print June 27 2005, 10.1073/pnas.0503277102 [Abstract] [Full Text] [Figures Only] [PDF]  

Qi-Qun Tang, Mads Grønborg, Haiyan Huang, Jae-Woo Kim, Tamara C. Otto, Akhilesh Pandey, and M. Daniel Lane
Sequential phosphorylation of CCAAT enhancer-binding protein {beta} by MAPK and glycogen synthase kinase 3{beta} is required for adipogenesis
PNAS 2005 102: 9766-9771; published online before print June 28 2005, 10.1073/pnas.0503891102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Kara R. Schmelzer, Lukas Kubala, John W. Newman, In-Hae Kim, Jason P. Eiserich, and Bruce D. Hammock
Soluble epoxide hydrolase is a therapeutic target for acute inflammation
PNAS 2005 102: 9772-9777; published online before print June 30 2005, 10.1073/pnas.0503279102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Neal F. Lue, Dimitry Bosoy, Tara J. Moriarty, Chantal Autexier, Brian Altman, and Siyang Leng
Telomerase can act as a template- and RNA-independent terminal transferase
PNAS 2005 102: 9778-9783; published online before print June 30 2005, 10.1073/pnas.0502252102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Kerstin Helmstaedt, Axel Strittmatter, William N. Lipscomb, and Gerhard H. Braus
From the Cover: Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae
PNAS 2005 102: 9784-9789; published online before print June 29 2005, 10.1073/pnas.0504238102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Biophysics

Thomas Heimburg and Andrew D. Jackson
On soliton propagation in biomembranes and nerves
PNAS 2005 102: 9790-9795; published online before print July 1 2005, 10.1073/pnas.0503823102 [Abstract] [Full Text] [Figures Only] [PDF]  

Y. M. Wang, Jonas O. Tegenfeldt, W. Reisner, R. Riehn, Xiao-Juan Guan, Ling Guo, Ido Golding, Edward C. Cox, James Sturm, and Robert H. Austin
Single-molecule studies of repressor–DNA interactions show long-range interactions
PNAS 2005 102: 9796-9801; published online before print June 30 2005, 10.1073/pnas.0502917102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Cell Biology

Fred Schaufele, Xavier Carbonell, Martin Guerbadot, Sabine Borngraeber, Mark S. Chapman, Aye Aye K. Ma, Jeffrey N. Miner, and Marc I. Diamond
The structural basis of androgen receptor activation: Intramolecular and intermolecular amino–carboxy interactions
PNAS 2005 102: 9802-9807; published online before print July 1 2005, 10.1073/pnas.0408819102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Konstantin Doubrovinski and Martin Howard
Stochastic model for Soj relocation dynamics in Bacillus subtilis
PNAS 2005 102: 9808-9813; published online before print July 5 2005, 10.1073/pnas.0500529102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sanna Lehtonen, Jennifer J. Ryan, Krystyna Kudlicka, Noriaki Iino, Huilin Zhou, and Marilyn G. Farquhar
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and {alpha}-actinin are components of the nephrin multiprotein complex
PNAS 2005 102: 9814-9819; published online before print July 1 2005, 10.1073/pnas.0504166102 [Abstract] [Full Text] [Figures Only] [PDF]  

Nicolas Prévost, Donna S. Woulfe, Hong Jiang, Timothy J. Stalker, Patrizia Marchese, Zaverio M. Ruggeri, and Lawrence F. Brass
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets
PNAS 2005 102: 9820-9825; published online before print July 1 2005, 10.1073/pnas.0404065102 [Abstract] [Full Text] [Figures Only] [PDF]  

Ecology

Erik M. Rauch and Yaneer Bar-Yam
Estimating the total genetic diversity of a spatial field population from a sample and implications of its dependence on habitat area
PNAS 2005 102: 9826-9829; published online before print July 5 2005, 10.1073/pnas.0408471102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Evolution

Jim R. Hughes, Jan-Fang Cheng, Nicki Ventress, Shyam Prabhakar, Kevin Clark, Eduardo Anguita, Marco De Gobbi, Pieter de Jong, Eddy Rubin, and Douglas R. Higgs
Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences
PNAS 2005 102: 9830-9835; published online before print July 5 2005, 10.1073/pnas.0503401102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marie Touchon, Samuel Nicolay, Benjamin Audit, Edward-Benedict Brodie of Brodie, Yves d'Aubenton-Carafa, Alain Arneodo, and Claude Thermes
Replication-associated strand asymmetries in mammalian genomes: Toward detection of replication origins
PNAS 2005 102: 9836-9841; published online before print June 28 2005, 10.1073/pnas.0500577102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

S. Nasuda, S. Hudakova, I. Schubert, A. Houben, and T. R. Endo
Stable barley chromosomes without centromeric repeats
PNAS 2005 102: 9842-9847; published online before print July 5 2005, 10.1073/pnas.0504235102 [Abstract] [Full Text] [Figures Only] [PDF]  

Marcel O. Vlad, Stefan E. Szedlacsek, Nader Pourmand, L. Luca Cavalli-Sforza, Peter Oefner, and John Ross
Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics
PNAS 2005 102: 9848-9853; published online before print June 30 2005, 10.1073/pnas.0504073102 [Abstract] [Full Text] [PDF]  

April J. Schumacher, Dwight V. Nissley, and Reuben S. Harris
APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast
PNAS 2005 102: 9854-9859; published online before print July 6 2005, 10.1073/pnas.0501694102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Immunology

Sumathi Sankaran, Moraima Guadalupe, Elizabeth Reay, Michael D. George, Jason Flamm, Thomas Prindiville, and Satya Dandekar
Gut mucosal T cell responses and gene expression correlate with protection against disease in long-term HIV-1-infected nonprogressors
PNAS 2005 102: 9860-9865; published online before print June 24 2005, 10.1073/pnas.0503463102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Pilar Martin, Ricardo Villares, Sandra Rodriguez-Mascarenhas, Angel Zaballos, Michael Leitges, Judit Kovac, Irene Sizing, Paul Rennert, Gabriel Márquez, Carlos Martínez-A, María T. Diaz-Meco, and Jorge Moscat
Control of T helper 2 cell function and allergic airway inflammation by PKC{zeta}
PNAS 2005 102: 9866-9871; published online before print June 29 2005, 10.1073/pnas.0501202102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

P'ng Loke, Xingxing Zang, Lisa Hsuan, Rebecca Waitz, Richard M. Locksley, Judith E. Allen, and James P. Allison
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
PNAS 2005 102: 9872-9877; published online before print July 1 2005, 10.1073/pnas.0503961102 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Dulal Panda, K. Rathinasamy, Manas K. Santra, and Leslie Wilson
From the Cover: Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancer
PNAS 2005 102: 9878-9883; published online before print June 28 2005, 10.1073/pnas.0501821102 [Abstract] [Full Text] [Figures Only] [PDF]  

Timothy R. Carlson, Yibing Yan, Xiaoqing Wu, Michael T. Lam, Gale L. Tang, Levi J. Beverly, Louis M. Messina, Anthony J. Capobianco, Zena Werb, and Rong Wang
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
PNAS 2005 102: 9884-9889; published online before print June 30 2005, 10.1073/pnas.0504391102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yuexing Zhang, Xin-Wei Wang, Danijela Jelovac, Takeo Nakanishi, Myoung-hee Yu, Damilola Akinmade, Olga Goloubeva, Douglas D. Ross, Angela Brodie, and Anne W. Hamburger
The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells
PNAS 2005 102: 9890-9895; published online before print June 30 2005, 10.1073/pnas.0503829102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Dongxiao Feng and Yuet Wai Kan
The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of {beta}-like globin genes
PNAS 2005 102: 9896-9900; published online before print July 5 2005, 10.1073/pnas.0502041102 [Abstract] [Full Text] [Figures Only] [PDF]  

Joseph E. Ippolito, Jian Xu, Sanjay Jain, Krista Moulder, Steven Mennerick, Jan R. Crowley, R. Reid Townsend, and Jeffrey I. Gordon
An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers
PNAS 2005 102: 9901-9906; published online before print July 5 2005, 10.1073/pnas.0500756102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Microbiology

Sophie Laurent, Han Chen, Sylvie Bédu, Fabio Ziarelli, Ling Peng, and Cheng-Cai Zhang
From the Cover: Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120
PNAS 2005 102: 9907-9912; published online before print June 28 2005, 10.1073/pnas.0502337102 [Abstract] [Full Text] [Figures Only] [PDF]  

Stefan F. Wieland, Angelina Eustaquio, Christina Whitten-Bauer, Bryan Boyd, and Francis V. Chisari
Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids
PNAS 2005 102: 9913-9917; published online before print July 1 2005, 10.1073/pnas.0504273102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Baoshan Zhang, Sha Jin, Jing Jin, Feng Li, and Ronald C. Montelaro
A tumor necrosis factor receptor family protein serves as a cellular receptor for the macrophage-tropic equine lentivirus
PNAS 2005 102: 9918-9923; published online before print June 28 2005, 10.1073/pnas.0501560102 [Abstract] [Full Text] [Figures Only] [PDF]  

John-Demian Sauer, Michael A. Bachman, and Michele S. Swanson
The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages
PNAS 2005 102: 9924-9929; published online before print July 5 2005, 10.1073/pnas.0502767102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Mark L. Urbanowski, Guinevere L. Lykken, and Timothy L. Yahr
A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system
PNAS 2005 102: 9930-9935; published online before print June 28 2005, 10.1073/pnas.0504405102 [Abstract] [Full Text] [Figures Only] [PDF]  

Neuroscience

Jianrong Li, Olivier Baud, Timothy Vartanian, Joseph J. Volpe, and Paul A. Rosenberg
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
PNAS 2005 102: 9936-9941; published online before print July 5 2005, 10.1073/pnas.0502552102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michele A. Kelly, Carsten T. Beuckmann, S. Clay Williams, Christopher M. Sinton, Toshiyuki Motoike, James A. Richardson, Robert E. Hammer, Mary G. Garry, and Masashi Yanagisawa
From the Cover: Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain
PNAS 2005 102: 9942-9947; published online before print June 27 2005, 10.1073/pnas.0503795102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Geoffrey Grinstein and Ralph Linsker
Synchronous neural activity in scale-free network models versus random network models
PNAS 2005 102: 9948-9953; published online before print July 5 2005, 10.1073/pnas.0504127102 [Abstract] [Full Text] [Figures Only] [PDF]  

Physiology

Anthony D. O'Connell, Qiang Leng, Ke Dong, Gordon G. MacGregor, Gerhard Giebisch, and Steven C. Hebert
Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK)
PNAS 2005 102: 9954-9959; published online before print June 29 2005, 10.1073/pnas.0504332102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Haibin Wang, Susanne Tranguch, Huirong Xie, Gregory Hanley, Sanjoy K. Das, and Sudhansu K. Dey
Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus
PNAS 2005 102: 9960-9965; published online before print June 29 2005, 10.1073/pnas.0501632102 [Abstract] [Full Text] [Figures Only] [PDF]  

Plant Biology

Jianhua Zhu, Paul E. Verslues, Xianwu Zheng, Byeong-ha Lee, Xiangqiang Zhan, Yuzuki Manabe, Irina Sokolchik, Yanmei Zhu, Chun-Hai Dong, Jian-Kang Zhu, Paul M. Hasegawa, and Ray A. Bressan
HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants
PNAS 2005 102: 9966-9971; published online before print July 1 2005, 10.1073/pnas.0503960102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Hitoshi Sakakibara, Hiroyuki Kasahara, Nanae Ueda, Mikiko Kojima, Kentaro Takei, Shojiro Hishiyama, Tadao Asami, Kazunori Okada, Yuji Kamiya, Tomoyuki Yamaya, and Shinjiro Yamaguchi
Agrobacterium tumefaciens increases cytokinin production in plastids by modifying the biosynthetic pathway in the host plant
PNAS 2005 102: 9972-9977; published online before print July 5 2005, 10.1073/pnas.0500793102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Psychology

Amir Raz, Jin Fan, and Michael I. Posner
Hypnotic suggestion reduces conflict in the human brain
PNAS 2005 102: 9978-9983; published online before print June 30 2005, 10.1073/pnas.0503064102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movie]  

CORRECTIONS

Correction for Jeschke et al., From The Cover: Invasion success of vertebrates in Europe and North America, PNAS 2005 102:7198-7202 [Extract] [Full Text] [PDF]  

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