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Table of Contents

January 18, 2005; 102 (3)  [Index By Author]  [Cover Photo]  [Masthead (PDF)]

FROM THE COVER

Plastid pathway generates isoprenoid volatiles

Iron chelation enhanced by C-glycosyltransferase

Visualizing protein unfolding over dynamic time scales

Dimeric DNA quadruplex inhibits HIV integrase

Insulin required for activation of lipid metabolism

IN THIS ISSUE

COMMENTARIES

PHYSICAL SCIENCES
    Chemistry
    Physics

SOCIAL SCIENCES
    Economic Sciences
    Environmental Sciences

BIOLOGICAL SCIENCES
    Agricultural Sciences
    Applied Biological Sciences
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Ecology
    Environmental Sciences
    Evolution
    Genetics

    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Physiology
    Plant Biology
    Psychology

CORRECTIONS

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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 517-518. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

Sherry S. Lamb and Gerard D. Wright
Accessorizing natural products: Adding to nature's toolbox
PNAS 2005 102: 519-520; published online before print January 12 2005, 10.1073/pnas.0408858102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 571

PHYSICAL SCIENCES

Chemistry

Qing-Hua Xu, Shu Wang, Dmitry Korystov, Alexander Mikhailovsky, Guillermo C. Bazan, Daniel Moses, and Alan J. Heeger
The fluorescence resonance energy transfer (FRET) gate: A time-resolved study
PNAS 2005 102: 530-535; published online before print January 10 2005, 10.1073/pnas.0408568102 [Abstract] [Full Text] [Figures Only] [PDF]  

Physics

Joseph K. Jun and Alfred H. Hübler
Formation and structure of ramified charge transportation networks in an electromechanical system
PNAS 2005 102: 536-540; published online before print January 6 2005, 10.1073/pnas.0406025102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

SOCIAL SCIENCES

Economic Sciences

John A. List and Michael S. Haigh
A simple test of expected utility theory using professional traders
PNAS 2005 102: 945-948; published online before print January 5 2005, 10.1073/pnas.0408022101 [Abstract] [Full Text] [Figures Only] [PDF]  

Environmental Sciences

Hugo R. Perales, Bruce F. Benz, and Stephen B. Brush
Maize diversity and ethnolinguistic diversity in Chiapas, Mexico
PNAS 2005 102: 949-954; published online before print January 7 2005, 10.1073/pnas.0408701102 [Abstract] [Full Text] [Figures Only] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

Naidan Luo, Sonia Pereira, Orhan Sahin, Jun Lin, Shouxiong Huang, Linda Michel, and Qijing Zhang
Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure
PNAS 2005 102: 541-546; published online before print January 5 2005, 10.1073/pnas.0408966102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Applied Biological Sciences

D. Huw Davies, Xiaowu Liang, Jenny E. Hernandez, Arlo Randall, Siddiqua Hirst, Yunxiang Mu, Kimberly M. Romero, Toai T. Nguyen, Mina Kalantari-Dehaghi, Shane Crotty, Pierre Baldi, Luis P. Villarreal, and Philip L. Felgner
Profiling the humoral immune response to infection by using proteome microarrays: High-throughput vaccine and diagnostic antigen discovery
PNAS 2005 102: 547-552; published online before print January 12 2005, 10.1073/pnas.0408782102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

Kai Tittmann, Maria Vyazmensky, Gerhard Hübner, Ze'ev Barak, and David M. Chipman
The carboligation reaction of acetohydroxyacid synthase II: Steady-state intermediate distributions in wild type and mutants by NMR
PNAS 2005 102: 553-558; published online before print January 7 2005, 10.1073/pnas.0408210101 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Edwin Cheung, Mari Luz Acevedo, Philip A. Cole, and W. Lee Kraus
Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1
PNAS 2005 102: 559-564; published online before print January 10 2005, 10.1073/pnas.0407113102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Jinyu Ren, Mingan Shi, Renshui Liu, Qi-Heng Yang, Teri Johnson, William C. Skarnes, and Chunying Du
The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development
PNAS 2005 102: 565-570; published online before print January 7 2005, 10.1073/pnas.0408744102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Michael A. Fischbach, Hening Lin, David R. Liu, and Christopher T. Walsh
From The Cover: In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase
PNAS 2005 102: 571-576; published online before print December 14 2004, 10.1073/pnas.0408463102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  
See Commentary on page 519

Pauline Macheboeuf, Anne Marie Di Guilmi, Viviana Job, Thierry Vernet, Otto Dideberg, and Andréa Dessen
Active site restructuring regulates ligand recognition in class A penicillin-binding proteins
PNAS 2005 102: 577-582; published online before print January 6 2005, 10.1073/pnas.0407186102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chu Kong Liew, Raina J. Y. Simpson, Ann H. Y. Kwan, Linda A. Crofts, Fionna E. Loughlin, Jacqueline M. Matthews, Merlin Crossley, and Joel P. Mackay
Zinc fingers as protein recognition motifs: Structural basis for the GATA-1/Friend of GATA interaction
PNAS 2005 102: 583-588; published online before print January 11 2005, 10.1073/pnas.0407511102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Bin Liu and Guillermo C. Bazan
Methods for strand-specific DNA detection with cationic conjugated polymers suitable for incorporation into DNA chips and microarrays
PNAS 2005 102: 589-593; published online before print January 10 2005, 10.1073/pnas.0408561102 [Abstract] [Full Text] [Figures Only] [PDF]  

Andrzej Weichsel, Estelle M. Maes, John F. Andersen, Jesus G. Valenzuela, Tatjana Kh. Shokhireva, F. Ann Walker, and William R. Montfort
Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein
PNAS 2005 102: 594-599; published online before print January 6 2005, 10.1073/pnas.0406549102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Galina Polekhina, Kara Sue Giddings, Rodney K. Tweten, and Michael W. Parker
Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin
PNAS 2005 102: 600-605; published online before print January 6 2005, 10.1073/pnas.0403229101 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jesse D. Bloom, Jonathan J. Silberg, Claus O. Wilke, D. Allan Drummond, Christoph Adami, and Frances H. Arnold
Thermodynamic prediction of protein neutrality
PNAS 2005 102: 606-611; published online before print January 11 2005, 10.1073/pnas.0406744102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Hoi Sung Chung, Munira Khalil, Adam W. Smith, Ziad Ganim, and Andrei Tokmakoff
From The Cover: Conformational changes during the nanosecond-to-millisecond unfolding of ubiquitin
PNAS 2005 102: 612-617; published online before print January 3 2005, 10.1073/pnas.0408646102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gregory E. Sims, In-Geol Choi, and Sung-Hou Kim
Protein conformational space in higher order {varphi}-{Psi} maps
PNAS 2005 102: 618-621; published online before print January 7 2005, 10.1073/pnas.0408746102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE  

Vitali Tugarinov, Wing-Yiu Choy, Vladislav Yu. Orekhov, and Lewis E. Kay
Solution NMR-derived global fold of a monomeric 82-kDa enzyme
PNAS 2005 102: 622-627; published online before print January 6 2005, 10.1073/pnas.0407792102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Giovanni Settanni, Francesco Rao, and Amedeo Caflisch
{Phi}-Value analysis by molecular dynamics simulations of reversible folding
PNAS 2005 102: 628-633; published online before print January 11 2005, 10.1073/pnas.0406754102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anh Tuân Phan, Vitaly Kuryavyi, Jin-Biao Ma, Aurélie Faure, Marie-Line Andréola, and Dinshaw J. Patel
From The Cover: An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase
PNAS 2005 102: 634-639; published online before print January 6 2005, 10.1073/pnas.0406278102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Dominikus A. Lysek, Christian Schorn, Lucas G. Nivon, Vicent Esteve-Moya, Barbara Christen, Luigi Calzolai, Christine von Schroetter, Francesco Fiorito, Torsten Herrmann, Peter Güntert, and Kurt Wüthrich
Prion protein NMR structures of cats, dogs, pigs, and sheep
PNAS 2005 102: 640-645; published online before print January 12 2005, 10.1073/pnas.0408937102 [Abstract] [Full Text] [Figures Only] [PDF]  

Alvar D. Gossert, Sophie Bonjour, Dominikus A. Lysek, Francesco Fiorito, and Kurt Wüthrich
Prion protein NMR structures of elk and of mouse/elk hybrids
PNAS 2005 102: 646-650; published online before print January 12 2005, 10.1073/pnas.0409008102 [Abstract] [Full Text] [Figures Only] [PDF]  

Luigi Calzolai, Dominikus A. Lysek, Daniel R. Pérez, Peter Güntert, and Kurt Wüthrich
Prion protein NMR structures of chickens, turtles, and frogs
PNAS 2005 102: 651-655; published online before print January 12 2005, 10.1073/pnas.0408939102 [Abstract] [Full Text] [Figures Only] [PDF]  

Huiyu Gong, Victoria Hatch, Laith Ali, William Lehman, Roger Craig, and Larry S. Tobacman
Mini-thin filaments regulated by troponin–tropomyosin
PNAS 2005 102: 656-661; published online before print January 11 2005, 10.1073/pnas.0407225102 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Charles Vidair and Harry Rubin
Mg2+ as activator of uridine phosphorylation in coordination with other cellular responses to growth factors
PNAS 2005 102: 662-666; published online before print January 12 2005, 10.1073/pnas.0409082102 [Abstract] [Full Text] [Figures Only] [PDF]  

Bryan A. Ballif, Philippe P. Roux, Scott A. Gerber, Jeffrey P. MacKeigan, John Blenis, and Steven P. Gygi
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
PNAS 2005 102: 667-672; published online before print January 12 2005, 10.1073/pnas.0409143102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

J. S. Ungerstedt, Y. Sowa, W.-S. Xu, Y. Shao, M. Dokmanovic, G. Perez, L. Ngo, A. Holmgren, X. Jiang, and P. A. Marks
Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors
PNAS 2005 102: 673-678; published online before print January 6 2005, 10.1073/pnas.0408732102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Developmental Biology

David N. Keys, Byung-in Lee, Anna Di Gregorio, Naoe Harafuji, J. Chris Detter, Mei Wang, Orsalem Kahsai, Sylvia Ahn, Cindy Zhang, Sharon A. Doyle, Noriyuki Satoh, Yutaka Satou, Hidetoshi Saiga, Allen T. Christian, Dan S. Rokhsar, Trevor L. Hawkins, Mike Levine, and Paul M. Richardson
A saturation screen for cis-acting regulatory DNA in the Hox genes of Ciona intestinalis
PNAS 2005 102: 679-683; published online before print January 12 2005, 10.1073/pnas.0408952102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table] OPEN ACCESS ARTICLE  

Ecology

Joel E. Cohen, Tomas Jonsson, Christine B. Müller, H. C. J. Godfray, and Van M. Savage
Body sizes of hosts and parasitoids in individual feeding relationships
PNAS 2005 102: 684-689; published online before print January 12 2005, 10.1073/pnas.0408780102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joy K. Ward, John M. Harris, Thure E. Cerling, Alex Wiedenhoeft, Michael J. Lott, Maria-Denise Dearing, Joan B. Coltrain, and James R. Ehleringer
Carbon starvation in glacial trees recovered from the La Brea tar pits, southern California
PNAS 2005 102: 690-694; published online before print January 10 2005, 10.1073/pnas.0408315102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table] OPEN ACCESS ARTICLE  

Jasper van Ruijven and Frank Berendse
Diversity–productivity relationships: Initial effects, long-term patterns, and underlying mechanisms
PNAS 2005 102: 695-700; published online before print January 7 2005, 10.1073/pnas.0407524102 [Abstract] [Full Text] [Figures Only] [PDF]  

Environmental Sciences

Weiping Liu, Jianying Gan, Daniel Schlenk, and William A. Jury
Enantioselectivity in environmental safety of current chiral insecticides
PNAS 2005 102: 701-706; published online before print January 4 2005, 10.1073/pnas.0408847102 [Abstract] [Full Text] [Figures Only] [PDF]  

Evolution

Xun Gu, Zhongqi Zhang, and Wei Huang
Rapid evolution of expression and regulatory divergences after yeast gene duplication
PNAS 2005 102: 707-712; published online before print January 12 2005, 10.1073/pnas.0409186102 [Abstract] [Full Text] [Figures Only] [PDF]  

Scott W. Roy and Walter Gilbert
The pattern of intron loss
PNAS 2005 102: 713-718; published online before print January 10 2005, 10.1073/pnas.0408274102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

John A. Petros, Amanda K. Baumann, Eduardo Ruiz-Pesini, Mahul B. Amin, Carrie Qi Sun, John Hall, SoDug Lim, Muta M. Issa, W. Dana Flanders, Seyed H. Hosseini, Fray F. Marshall, and Douglas C. Wallace
mtDNA mutations increase tumorigenicity in prostate cancer
PNAS 2005 102: 719-724; published online before print January 12 2005, 10.1073/pnas.0408894102 [Abstract] [Full Text] [Figures Only] [PDF]  

Anne Dupressoir, Geoffroy Marceau, Cécile Vernochet, Laurence Bénit, Colette Kanellopoulos, Vincent Sapin, and Thierry Heidmann
Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae
PNAS 2005 102: 725-730; published online before print January 11 2005, 10.1073/pnas.0406509102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Andrew Slack, Zaowen Chen, Roberto Tonelli, Martin Pule, Lisa Hunt, Andrea Pession, and Jason M. Shohet
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma
PNAS 2005 102: 731-736; published online before print January 11 2005, 10.1073/pnas.0405495102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Monica Di Giacomo, Marco Barchi, Frédéric Baudat, Winfried Edelmann, Scott Keeney, and Maria Jasin
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants
PNAS 2005 102: 737-742; published online before print January 7 2005, 10.1073/pnas.0406212102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yael Heifetz, Laura N. Vandenberg, Heather I. Cohn, and Mariana F. Wolfner
Two cleavage products of the Drosophila accessory gland protein ovulin can independently induce ovulation
PNAS 2005 102: 743-748; published online before print January 7 2005, 10.1073/pnas.0407692102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Medical Sciences

Thomas A. Milne, Christina M. Hughes, Ricardo Lloyd, Zhaohai Yang, Orit Rozenblatt-Rosen, Yali Dou, Robert W. Schnepp, Cynthia Krankel, Virginia A. LiVolsi, Denise Gibbs, Xianxin Hua, Robert G. Roeder, Matthew Meyerson, and Jay L. Hess
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
PNAS 2005 102: 749-754; published online before print January 7 2005, 10.1073/pnas.0408836102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ming Zhao, Meng Yang, Xiao-Ming Li, Ping Jiang, Eugene Baranov, Shukuan Li, Mingxu Xu, Sheldon Penman, and Robert M. Hoffman
Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium
PNAS 2005 102: 755-760; published online before print January 11 2005, 10.1073/pnas.0408422102 [Abstract] [Full Text] [Figures Only] [PDF]  

Pascal N. Bernatchez, Philip M. Bauer, Jun Yu, Jay S. Prendergast, Pingnian He, and William C. Sessa
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides
PNAS 2005 102: 761-766; published online before print January 6 2005, 10.1073/pnas.0407224102 [Abstract] [Full Text] [Figures Only] [PDF]  

Matt X. G. Shao and Jay A. Nadel
Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells
PNAS 2005 102: 767-772; published online before print January 7 2005, 10.1073/pnas.0408932102 [Abstract] [Full Text] [Figures Only] [PDF]  

Susan L. Uprichard, Bryan Boyd, Alana Althage, and Francis V. Chisari
Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs
PNAS 2005 102: 773-778; published online before print January 7 2005, 10.1073/pnas.0409028102 [Abstract] [Full Text] [Figures Only] [PDF]  

Timothy M. Block, Mary Ann Comunale, Melissa Lowman, Laura F. Steel, Patrick R. Romano, Claus Fimmel, Bud C. Tennant, W. Thomas London, Alison A. Evans, Baruch S. Blumberg, Raymond A. Dwek, Tajinder S. Mattu, and Anand S. Mehta
Use of targeted glycoproteomics to identify serum glycoproteins that correlate with liver cancer in woodchucks and humans
PNAS 2005 102: 779-784; published online before print January 10 2005, 10.1073/pnas.0408928102 [Abstract] [Full Text] [Figures Only] [PDF]  

Joyce C. Y. Chan, Ole Knudson, Faye Wu, John Morser, William P. Dole, and Qingyu Wu
Hypertension in mice lacking the proatrial natriuretic peptide convertase corin
PNAS 2005 102: 785-790; published online before print January 6 2005, 10.1073/pnas.0407234102 [Abstract] [Full Text] [Figures Only] [PDF]  

Bronwyn D. Hegarty, Alexandre Bobard, Isabelle Hainault, Pascal Ferré, Pascale Bossard, and Fabienne Foufelle
From The Cover: Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory elementbinding protein-1c
PNAS 2005 102: 791-796; published online before print January 6 2005, 10.1073/pnas.0405067102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Zhi-yong Yang, Heidi C. Werner, Wing-pui Kong, Kwanyee Leung, Elisabetta Traggiai, Antonio Lanzavecchia, and Gary J. Nabel
Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses
PNAS 2005 102: 797-801; published online before print January 10 2005, 10.1073/pnas.0409065102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Sohye Kang, Andreas G. Bader, and Peter K. Vogt
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
PNAS 2005 102: 802-807; published online before print January 12 2005, 10.1073/pnas.0408864102 [Abstract] [Full Text] [Figures Only] [PDF]  

Robert G. Weiss, Gary Gerstenblith, and Paul A. Bottomley
ATP flux through creatine kinase in the normal, stressed, and failing human heart
PNAS 2005 102: 808-813; published online before print January 12 2005, 10.1073/pnas.0408962102 [Abstract] [Full Text] [Figures Only] [PDF]  

Microbiology

Axel Martinelli, Sandra Cheesman, Paul Hunt, Richard Culleton, Ahmed Raza, Margaret Mackinnon, and Richard Carter
A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites
PNAS 2005 102: 814-819; published online before print January 7 2005, 10.1073/pnas.0405097102 [Abstract] [Full Text] [Figures Only] [PDF]  

Myung-Soo Kang, Hongxiang Lu, Teruhito Yasui, Arlene Sharpe, Henry Warren, Ellen Cahir-McFarland, Roderick Bronson, Siu Chun Hung, and Elliott Kieff
Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice
PNAS 2005 102: 820-825; published online before print January 7 2005, 10.1073/pnas.0408774102 [Abstract] [Full Text] [Figures Only] [PDF]  

Hiroki Nagai, Eric D. Cambronne, Jonathan C. Kagan, Juan Carlos Amor, Richard A. Kahn, and Craig R. Roy
A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells
PNAS 2005 102: 826-831; published online before print December 21 2004, 10.1073/pnas.0406239101 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Annette C. Vergunst, Miranda C. M. van Lier, Amke den Dulk-Ras, Thomas A. Grosse Stüve, Anette Ouwehand, and Paul J. J. Hooykaas
Positive charge is an important feature of the C-terminal transport signal of the VirB/D4-translocated proteins of Agrobacterium
PNAS 2005 102: 832-837; published online before print January 11 2005, 10.1073/pnas.0406241102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nicola E. Collins, Junita Liebenberg, Etienne P. de Villiers, Kelly A. Brayton, Elmarié Louw, Alri Pretorius, F. Erika Faber, Henriette van Heerden, Antoinette Josemans, Mirinda van Kleef, Helena C. Steyn, M. Fransie van Strijp, Erich Zweygarth, Frans Jongejan, Jean Charles Maillard, David Berthier, Marli Botha, Fourie Joubert, Craig H. Corton, Nicholas R. Thomson, Maria T. Allsopp, and Basil A. Allsopp
The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number
PNAS 2005 102: 838-843; published online before print January 6 2005, 10.1073/pnas.0406633102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kelly A. Brayton, Lowell S. Kappmeyer, David R. Herndon, Michael J. Dark, David L. Tibbals, Guy H. Palmer, Travis C. McGuire, and Donald P. Knowles, Jr.
Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins
PNAS 2005 102: 844-849; published online before print December 23 2004, 10.1073/pnas.0406656102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Scott R. Miller, Sunny Augustine, Tien Le Olson, Robert E. Blankenship, Jeanne Selker, and A. Michelle Wood
Discovery of a free-living chlorophyll d-producing cyanobacterium with a hybrid proteobacterial/cyanobacterial small-subunit rRNA gene
PNAS 2005 102: 850-855; published online before print January 6 2005, 10.1073/pnas.0405667102 [Abstract] [Full Text] [Figures Only] [PDF]  

Ralf Schulein, Patrick Guye, Thomas A. Rhomberg, Michael C. Schmid, Gunnar Schröder, Annette C. Vergunst, Ilaria Carena, and Christoph Dehio
A bipartite signal mediates the transfer of type IV secretion substrates of Bartonella henselae into human cells
PNAS 2005 102: 856-861; published online before print January 10 2005, 10.1073/pnas.0406796102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Emma Hitt
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Biography of William T. Newsome
PNAS 2005 102: 521-523; published online before print January 12 2005, 10.1073/pnas.0409116102 [Extract] [Full Text] [Figures Only] [PDF]  

James R. Müller, Marios G. Philiastides, and William T. Newsome
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Microstimulation of the superior colliculus focuses attention without moving the eyes
PNAS 2005 102: 524-529; published online before print December 15 2004, 10.1073/pnas.0408311101 [Abstract] [Full Text] [Figures Only] [PDF]  

Hannelore Ehrenreich, Martin Hasselblatt, Friederike Knerlich, Nico von Ahsen, Sonja Jacob, Swetlana Sperling, Helge Woldt, Katalin Vehmeyer, Klaus-Armin Nave, and Anna-Leena Sirén
A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain
PNAS 2005 102: 862-867; published online before print January 10 2005, 10.1073/pnas.0406008102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Subramaniam Jayanthi, Xiaolin Deng, Bruce Ladenheim, Michael T. McCoy, Andrew Cluster, Ning-sheng Cai, and Jean Lud Cadet
Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
PNAS 2005 102: 868-873; published online before print January 11 2005, 10.1073/pnas.0404990102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xiaoying Lu, Alasdair M. Barr, Jefferson W. Kinney, Pietro Sanna, Bruno Conti, M. Margarita Behrens, and Tamas Bartfai
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
PNAS 2005 102: 874-879; published online before print January 12 2005, 10.1073/pnas.0408891102 [Abstract] [Full Text] [Figures Only] [PDF]  

Nir Kalisman, Gilad Silberberg, and Henry Markram
The neocortical microcircuit as a tabula rasa
PNAS 2005 102: 880-885; published online before print January 3 2005, 10.1073/pnas.0407088102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Nako Ishikura, Jared L. Clever, Essia Bouzamondo-Bernstein, Erik Samayoa, Stanley B. Prusiner, Eric J. Huang, and Stephen J. DeArmond
Notch-1 activation and dendritic atrophy in prion disease
PNAS 2005 102: 886-891; published online before print January 7 2005, 10.1073/pnas.0408612101 [Abstract] [Full Text] [Figures Only] [PDF]  

Xiaoqian Zhang, Donna L. Smith, Anatoli B. Meriin, Sabine Engemann, Deborah E. Russel, Margo Roark, Shetia L. Washington, Michele M. Maxwell, J. Lawrence Marsh, Leslie Michels Thompson, Erich E. Wanker, Anne B. Young, David E. Housman, Gillian P. Bates, Michael Y. Sherman, and Aleksey G. Kazantsev
A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo
PNAS 2005 102: 892-897; published online before print January 10 2005, 10.1073/pnas.0408936102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

L. Cattaneo, M. Voss, T. Brochier, G. Prabhu, D. M. Wolpert, and R. N. Lemon
A cortico-cortical mechanism mediating object-driven grasp in humans
PNAS 2005 102: 898-903; published online before print January 10 2005, 10.1073/pnas.0409182102 [Abstract] [Full Text] [Figures Only] [PDF]  

Pharmacology

Mariarosaria Bucci, Fiorentina Roviezzo, Inmaculada Posadas, Jun Yu, Luca Parente, William C. Sessa, Louis J. Ignarro, and Giuseppe Cirino
Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo
PNAS 2005 102: 904-908; published online before print January 7 2005, 10.1073/pnas.0408906102 [Abstract] [Full Text] [Figures Only] [PDF]  

Yang Xiang, Fabio Naro, Maria Zoudilova, S.-L. Catherine Jin, Marco Conti, and Brian Kobilka
Phosphodiesterase 4D is required for {beta}2 adrenoceptor subtype-specific signaling in cardiac myocytes
PNAS 2005 102: 909-914; published online before print January 11 2005, 10.1073/pnas.0405263102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

James K. Rowlett, Donna M. Platt, Snjezana Lelas, John R. Atack, and Gerard R. Dawson
Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates
PNAS 2005 102: 915-920; published online before print January 11 2005, 10.1073/pnas.0405621102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Physiology

Joseph F. Hoffman and John P. Geibel
Fluorescent imaging of Cl- in Amphiuma red blood cells: How the nuclear exclusion of Cl- affects the plasma membrane potential
PNAS 2005 102: 921-926; published online before print January 6 2005, 10.1073/pnas.0408597102 [Abstract] [Full Text] [Figures Only] [PDF]  

Diego F. Fiol and Dietmar Kültz
Rapid hyperosmotic coinduction of two tilapia (Oreochromis mossambicus) transcription factors in gill cells
PNAS 2005 102: 927-932; published online before print January 10 2005, 10.1073/pnas.0408956102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Plant Biology

Natalia Dudareva, Susanna Andersson, Irina Orlova, Nathalie Gatto, Michael Reichelt, David Rhodes, Wilhelm Boland, and Jonathan Gershenzon
From The Cover: The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers
PNAS 2005 102: 933-938; published online before print January 3 2005, 10.1073/pnas.0407360102 [Abstract] [Full Text] [Figures Only] [PDF]  

Psychology

Manish Singh and Jacqueline M. Fulvio
Visual extrapolation of contour geometry
PNAS 2005 102: 939-944; published online before print January 12 2005, 10.1073/pnas.0408444102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

CORRECTIONS

Correction for Boles et al., From the Cover: Self-generated diversity produces "insurance effects" in biofilm communities, PNAS 2004 101:16630-16635 [Extract] [Full Text] [PDF]  

Correction for Colby et al., Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody, PNAS 2004 101:17616-17621 [Extract] [Full Text] [PDF]  

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