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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 957. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

George F. Sprague, Jr.

Three-pronged genomic analysis reveals yeast cell-type regulation circuitry
PNAS 2005 102: 959-960; published online before print January 18 2005, 10.1073/pnas.0409007102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 18069 in issue 52 of volume 101

PHYSICAL SCIENCES

Chemistry

Bruce E. Cohen, Arnd Pralle, XiaoJie Yao, Gayathri Swaminath, Chris S. Gandhi, Yuh Nung Jan, Brian K. Kobilka, Ehud Y. Isacoff, and Lily Y. Jan

A fluorescent probe designed for studying protein conformational change
PNAS 2005 102: 965-970; published online before print January 18 2005, 10.1073/pnas.0409469102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jian-Ru Gong, Li-Jun Wan, Qun-Hui Yuan, Chun-Li Bai, Hershel Jude, and Peter J. Stang

Mesoscopic self-organization of a self-assembled supramolecular rectangle on highly oriented pyrolytic graphite and Au(111) surfaces
PNAS 2005 102: 971-974; published online before print January 18 2005, 10.1073/pnas.0409145102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Xingyu Jiang, Derek A. Bruzewicz, Amy P. Wong, Matthieu Piel, and George M. Whitesides

Directing cell migration with asymmetric micropatterns
PNAS 2005 102: 975-978; published online before print January 14 2005, 10.1073/pnas.0408954102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Geology

Karim Benzerara, Tae Hyun Yoon, Nicolas Menguy, Tolek Tyliszczak, and Gordon E. Brown, Jr.

Nanoscale environments associated with bioweathering of a Mg-Fe-pyroxene
PNAS 2005 102: 979-982; published online before print January 12 2005, 10.1073/pnas.0409029102 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Economic Sciences

Michele Boldrin and David K. Levine

The economics of ideas and intellectual property
PNAS 2005 102: 1252-1256; published online before print January 18 2005, 10.1073/pnas.0407730102 [Abstract] [Full Text] [PDF]  

Psychology

Mark Wexler

Anticipating the three-dimensional consequences of eye movements
PNAS 2005 102: 1246-1251; published online before print January 18 2005, 10.1073/pnas.0409241102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Biochemistry

Manal A. Swairjo and Paul R. Schimmel

Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase
PNAS 2005 102: 988-993; published online before print January 18 2005, 10.1073/pnas.0409024102 [Abstract] [Full Text] [Figures Only] [PDF]  

R. August Estabrook, Jia Luo, Matthew M. Purdy, Vyas Sharma, Paul Weakliem, Thomas C. Bruice, and Norbert O. Reich

Statistical coevolution analysis and molecular dynamics: Identification of amino acid pairs essential for catalysis
PNAS 2005 102: 994-999; published online before print January 18 2005, 10.1073/pnas.0409128102 [Abstract] [Full Text] [Figures Only] [PDF]  

Pierre-Olivier Estève, Hang Gyeong Chin, and Sriharsa Pradhan Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters PNAS 2005 102: 1000-1005; published online before print January 18 2005, 10.1073/pnas.0407729102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Kristin Coffman Haddad, James L. Sudmeier, Daniel A. Bachovchin, and William W. Bachovchin

-Lytic protease can exist in two separately stable conformations with different His⁵⁷ mobilities and catalytic activities
PNAS 2005 102: 1006-1011; published online before print January 18 2005, 10.1073/pnas.0409279102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yuki Ogasawara, Gerard M. Lacourciere, Kazuyuki Ishii, and Thressa C. Stadtman

Characterization of potential selenium-binding proteins in the selenophosphate synthetase system
PNAS 2005 102: 1012-1016; published online before print January 14 2005, 10.1073/pnas.0409042102 [Abstract] [Full Text] [Figures Only] [PDF]  

Xuedong Kang, Kestrel Rogers, Guanghan Gao, Arnold M. Falick, Sharleen Zhou, and Larry Simpson

Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes
PNAS 2005 102: 1017-1022; published online before print January 18 2005, 10.1073/pnas.0409275102 [Abstract] [Full Text] [Figures Only] [PDF]  

Yvonne Berghöfer-Hochheimer, Chi Zen Lu, and Carol A. Gross

Altering the interaction between ⁷⁰ and RNA polymerase generates complexes with distinct transcription-elongation properties
PNAS 2005 102: 1157-1162; published online before print January 13 2005, 10.1073/pnas.0408973102 [Abstract] [Full Text] [Figures Only] [PDF]  

Biophysics

Bruce E. Cohen, Arnd Pralle, XiaoJie Yao, Gayathri Swaminath, Chris S. Gandhi, Yuh Nung Jan, Brian K. Kobilka, Ehud Y. Isacoff, and Lily Y. Jan

A fluorescent probe designed for studying protein conformational change
PNAS 2005 102: 965-970; published online before print January 18 2005, 10.1073/pnas.0409469102 [Abstract] [Full Text] [Figures Only] [PDF]  

Tanvir R. Shaikh, Dennis R. Thomas, James Z. Chen, Fadel A. Samatey, Hideyuki Matsunami, Katsumi Imada, Keiichi Namba, and David J. DeRosier

A partial atomic structure for the flagellar hook of Salmonella typhimurium
PNAS 2005 102: 1023-1028; published online before print January 18 2005, 10.1073/pnas.0409020102 [Abstract] [Full Text] [Figures Only] [PDF]  

Yang Zhang and Jeffrey Skolnick

The protein structure prediction problem could be solved using the current PDB library
PNAS 2005 102: 1029-1034; published online before print January 14 2005, 10.1073/pnas.0407152101 [Abstract] [Full Text] [Figures Only] [PDF]  

Yu Bai, Rhiju Das, Ian S. Millett, Daniel Herschlag, and Sebastian Doniach

Probing counterion modulated repulsion and attraction between nucleic acid duplexes in solution
PNAS 2005 102: 1035-1040; published online before print January 12 2005, 10.1073/pnas.0404448102 [Abstract] [Full Text] [Figures Only] [PDF] [Suporting Information]  

Alison M. Skelley, James R. Scherer, Andrew D. Aubrey, William H. Grover, Robin H. C. Ivester, Pascale Ehrenfreund, Frank J. Grunthaner, Jeffrey L. Bada, and Richard A. Mathies

Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars
PNAS 2005 102: 1041-1046; published online before print January 18 2005, 10.1073/pnas.0406798102 [Abstract] [Full Text] [Figures Only] [PDF]  

Willy Supatto, Delphine Débarre, Bruno Moulia, Eric Brouzés, Jean-Louis Martin, Emmanuel Farge, and Emmanuel Beaurepaire

In vivo modulation of morphogenetic movements in Drosophila embryos with femtosecond laser pulses
PNAS 2005 102: 1047-1052; published online before print January 18 2005, 10.1073/pnas.0405316102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

Mallela M. G. Krishna and S. Walter Englander

The N-terminal to C-terminal motif in protein folding and function
PNAS 2005 102: 1053-1058; published online before print January 18 2005, 10.1073/pnas.0409114102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

Zhao-Zhong Su, Devanand Sarkar, Luni Emdad, Gregory J. Duigou, Charles S. H. Young, Joy Ware, Aaron Randolph, Kristoffer Valerie, and Paul B. Fisher

Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter
PNAS 2005 102: 1059-1064; published online before print January 12 2005, 10.1073/pnas.0409141102 [Abstract] [Full Text] [Figures Only] [PDF]  

Xingxu Huang, Thanh Tran, Lingna Zhang, Rashieda Hatcher, and Pumin Zhang

DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint
PNAS 2005 102: 1065-1070; published online before print January 13 2005, 10.1073/pnas.0409130102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Steven A. Frank

Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis
PNAS 2005 102: 1071-1075; published online before print January 18 2005, 10.1073/pnas.0407299102 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Yoshiko Sakurai, Kaori Ohgimoto, Yuki Kataoka, Nobuaki Yoshida, and Masabumi Shibuya

Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice
PNAS 2005 102: 1076-1081; published online before print January 11 2005, 10.1073/pnas.0404984102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shijie Li, Michael P. Czubryt, John McAnally, Rhonda Bassel-Duby, James A. Richardson, Franziska F. Wiebel, Alfred Nordheim, and Eric N. Olson

Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice
PNAS 2005 102: 1082-1087; published online before print January 12 2005, 10.1073/pnas.0409103102 [Abstract] [Full Text] [Figures Only] [PDF]  

Ecology

Edwin D. Grosholz

Recent biological invasion may hasten invasional meltdown by accelerating historical introductions
PNAS 2005 102: 1088-1091; published online before print January 18 2005, 10.1073/pnas.0308547102 [Abstract] [Full Text] [Figures Only] [PDF]  

Evolution

Zhenglong Gu, Lior David, Dmitri Petrov, Ted Jones, Ronald W. Davis, and Lars M. Steinmetz

Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae
PNAS 2005 102: 1092-1097; published online before print January 12 2005, 10.1073/pnas.0409159102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Yan Leng, Jinyi Zhang, Karen Badour, Enrico Arpaia, Spencer Freeman, Pam Cheung, Michael Siu, and Katherine Siminovitch

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation
PNAS 2005 102: 1098-1103; published online before print January 18 2005, 10.1073/pnas.0409120102 [Abstract] [Full Text] [Figures Only] [PDF]  

Yue-Ying Wang, Guang-Biao Zhou, Tong Yin, Bing Chen, Jing-Yi Shi, Wen-Xue Liang, Xiao-Long Jin, Jian-Hua You, Guang Yang, Zhi-Xiang Shen, Jue Chen, Shu-Min Xiong, Guo-Qiang Chen, Feng Xu, Yi-Wei Liu, Zhu Chen, and Sai-Juan Chen

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec
PNAS 2005 102: 1104-1109; published online before print January 13 2005, 10.1073/pnas.0408831102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Koji Nakanishi, Yun-Gui Yang, Andrew J. Pierce, Toshiyasu Taniguchi, Martin Digweed, Alan D. D'Andrea, Zhao-Qi Wang, and Maria Jasin

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair
PNAS 2005 102: 1110-1115; published online before print January 13 2005, 10.1073/pnas.0407796102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Immunology

Kwang-Min Choe, Hyangkyu Lee, and Kathryn V. Anderson

Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor
PNAS 2005 102: 1122-1126; published online before print January 18 2005, 10.1073/pnas.0404952102 [Abstract] [Full Text] [Figures Only] [PDF]  

John Schmieg, Guangli Yang, Richard W. Franck, Nico Van Rooijen, and Moriya Tsuji

Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion
PNAS 2005 102: 1127-1132; published online before print January 11 2005, 10.1073/pnas.0408288102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Medical Sciences

Mariko Eguchi, Minenori Eguchi-Ishimae, Anthony Green, Tariq Enver, and Mel Greaves

Directing oncogenic fusion genes into stem cells via an SCL enhancer
PNAS 2005 102: 1133-1138; published online before print January 13 2005, 10.1073/pnas.0405318102 [Abstract] [Full Text] [Figures Only] [PDF]  

William S. Mason, Allison R. Jilbert, and Jesse Summers Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection PNAS 2005 102: 1139-1144; published online before print January 18 2005, 10.1073/pnas.0409332102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Chetan Bettegowda, Catherine A. Foss, Ian Cheong, Yuchuan Wang, Luis Diaz, Nishant Agrawal, James Fox, James Dick, Long H. Dang, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein, and Martin G. Pomper From the Cover: Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro--D-arabinofuranosyl)-5-iodouracil PNAS 2005 102: 1145-1150; published online before print January 14 2005, 10.1073/pnas.0408861102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]

Guangzhou Han, Grant Buchanan, Michael Ittmann, Jonathan M. Harris, Xiaoqing Yu, Francesco J. DeMayo, Wayne Tilley, and Norman M. Greenberg Mutation of the androgen receptor causes oncogenic transformation of the prostate PNAS 2005 102: 1151-1156; published online before print January 18 2005, 10.1073/pnas.0408925102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Microbiology

Yvonne Berghöfer-Hochheimer, Chi Zen Lu, and Carol A. Gross

Altering the interaction between ⁷⁰ and RNA polymerase generates complexes with distinct transcription-elongation properties
PNAS 2005 102: 1157-1162; published online before print January 13 2005, 10.1073/pnas.0408973102 [Abstract] [Full Text] [Figures Only] [PDF]  

Tracy Raymond, Elena Gorbunova, Irina N. Gavrilovskaya, and Erich R. Mackow

Pathogenic hantaviruses bind plexin–semaphorin–integrin domains present at the apex of inactive, bent v3 integrin conformers
PNAS 2005 102: 1163-1168; published online before print January 18 2005, 10.1073/pnas.0406743102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Monica L. Burts, Wade A. Williams, Kristin DeBord, and Dominique M. Missiakas

EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections
PNAS 2005 102: 1169-1174; published online before print January 18 2005, 10.1073/pnas.0405620102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ricardo B. de Medeiros, Juliana Figueiredo, Renato de O. Resende, and Antonio C. De Avila

Expression of a viral polymerase-bound host factor turns human cell lines permissive to a plant- and insect-infecting virus
PNAS 2005 102: 1175-1180; published online before print January 18 2005, 10.1073/pnas.0406668102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Neuroscience

Virginie van Wassenhove, Ken W. Grant, and David Poeppel

Visual speech speeds up the neural processing of auditory speech
PNAS 2005 102: 1181-1186; published online before print January 12 2005, 10.1073/pnas.0408949102 [Abstract] [Full Text] [Figures Only] [PDF]  

Naoya Sawamura, Takako Sawamura-Yamamoto, Yuji Ozeki, Christopher A. Ross, and Akira Sawa

A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse
PNAS 2005 102: 1187-1192; published online before print January 18 2005, 10.1073/pnas.0406543102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tore Eid, Tih-Shih W. Lee, Marion J. Thomas, Mahmood Amiry-Moghaddam, Lars P. Bjørnsen, Dennis D. Spencer, Peter Agre, Ole P. Ottersen, and Nihal C. de Lanerolle

Loss of perivascular aquaporin 4 may underlie deficient water and K⁺ homeostasis in the human epileptogenic hippocampus
PNAS 2005 102: 1193-1198; published online before print January 18 2005, 10.1073/pnas.0409308102 [Abstract] [Full Text] [Figures Only] [PDF]  

Akinori Nishi, Yasuo Watanabe, Hideho Higashi, Masatoshi Tanaka, Angus C. Nairn, and Paul Greengard

Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades
PNAS 2005 102: 1199-1204; published online before print January 18 2005, 10.1073/pnas.0409138102 [Abstract] [Full Text] [Figures Only] [PDF]  

Binhai Zheng, Jasvinder Atwal, Carole Ho, Lauren Case, Xiao-lin He, K. Christopher Garcia, Oswald Steward, and Marc Tessier-Lavigne From the Cover: Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo PNAS 2005 102: 1205-1210; published online before print January 12 2005, 10.1073/pnas.0409026102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Online Correction to Supporting Figures 6 and 7] OPEN ACCESS ARTICLE

Jean-Cosme Dodart, Robert A. Marr, Milla Koistinaho, Beth M. Gregersen, Seema Malkani, Inder M. Verma, and Steven M. Paul Gene delivery of human apolipoprotein E alters brain A burden in a mouse model of Alzheimer's disease PNAS 2005 102: 1211-1216; published online before print January 18 2005, 10.1073/pnas.0409072102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE

Mauro Cesar Isoldi, Mark D. Rollag, Ana Maria de Lauro Castrucci, and Ignacio Provencio

Rhabdomeric phototransduction initiated by the vertebrate photopigment melanopsin
PNAS 2005 102: 1217-1221; published online before print January 14 2005, 10.1073/pnas.0409252102 [Abstract] [Full Text] [Figures Only] [PDF]  

Surajit Ganguly, Joan L. Weller, Anthony Ho, Philippe Chemineau, Benoit Malpaux, and David C. Klein Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205 PNAS 2005 102: 1222-1227; published online before print January 11 2005, 10.1073/pnas.0406871102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Catherine Q. Howe and Dale Purves Natural-scene geometry predicts the perception of angles and line orientation PNAS 2005 102: 1228-1233; published online before print January 18 2005, 10.1073/pnas.0409311102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text] OPEN ACCESS ARTICLE

Catherine Q. Howe and Dale Purves The Müller-Lyer illusion explained by the statistics of image–source relationships PNAS 2005 102: 1234-1239; published online before print January 18 2005, 10.1073/pnas.0409314102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

Physiology

Psychology

Mark Wexler

Anticipating the three-dimensional consequences of eye movements
PNAS 2005 102: 1246-1251; published online before print January 18 2005, 10.1073/pnas.0409241102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

CORRECTIONS

Correction for Nedvetzki et al., RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: A different interpretation of redundancy, PNAS 2004 101:18081-18086 [Extract] [Full Text] [PDF]