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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 14937-14938. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

David Jeruzalmi

The opened processivity clamp slides into view
PNAS 2005 102: 14939-14940; published online before print October 10 2005, 10.1073/pnas.0507120102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 13795 in issue 39 of volume 102
See companion article on page 13801 in issue 39 of volume 102

Timothy F. Walseth

A multifunctional enzyme adds to its repertoire
PNAS 2005 102: 14941-14942; published online before print October 10 2005, 10.1073/pnas.0507258102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 14509 in issue 41 of volume 102

PERSPECTIVES

Dennis R. Burton, Robyn L. Stanfield, and Ian A. Wilson

Antibody vs. HIV in a clash of evolutionary titans
PNAS 2005 102: 14943-14948; published online before print October 11 2005, 10.1073/pnas.0505126102 [Abstract] [Full Text] [Figures Only] [PDF]  

PROFILES

Philip Downey

Profile of Akira Tonomura
PNAS 2005 102: 14949-14951; published online before print October 10 2005, 10.1073/pnas.0506215102 [Extract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

Christian Hilty, Erin E. McDonnell, Josef Granwehr, Kimberly L. Pierce, Song-I Han, and Alexander Pines

Microfluidic gas-flow profiling using remote-detection NMR
PNAS 2005 102: 14960-14963; published online before print October 7 2005, 10.1073/pnas.0507566102 [Abstract] [Full Text] [Figures Only] [PDF]  

Geology

Volker Mosbrugger, Torsten Utescher, and David L. Dilcher

Cenozoic continental climatic evolution of Central Europe
PNAS 2005 102: 14964-14969; published online before print October 10 2005, 10.1073/pnas.0505267102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Geophysics

Physics

Dmitry Pestov, Miaochan Zhi, Zoe-Elizabeth Sariyanni, Nikolai G. Kalugin, Alexandre A. Kolomenskii, Robert Murawski, Gerhard G. Paulus, Vladimir A. Sautenkov, Hans Schuessler, Alexei V. Sokolov, George R. Welch, Yuri V. Rostovtsev, Torsten Siebert, Denis A. Akimov, Stefanie Graefe, Wolfgang Kiefer, and Marlan O. Scully

Visible and UV coherent Raman spectroscopy of dipicolinic acid
PNAS 2005 102: 14976-14981; published online before print October 10 2005, 10.1073/pnas.0506529102 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Psychology

Jordy Kaufman, Gergely Csibra, and Mark H. Johnson

Oscillatory activity in the infant brain reflects object maintenance
PNAS 2005 102: 15271-15274; published online before print October 17 2005, 10.1073/pnas.0507626102 [Abstract] [Full Text] [Figures Only] [PDF]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Shu-ichi Matsuzawa, Michael Cuddy, Toru Fukushima, and John C. Reed

Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway
PNAS 2005 102: 14982-14987; published online before print October 11 2005, 10.1073/pnas.0507512102 [Abstract] [Full Text] [Figures Only] [PDF]  

Biochemistry

F.-X. Campbell-Valois, K. Tarassov, and S. W. Michnick

Massive sequence perturbation of a small protein
PNAS 2005 102: 14988-14993; published online before print October 7 2005, 10.1073/pnas.0500465102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Susana L. A. Andrade, Antje Dickmanns, Ralf Ficner, and Oliver Einsle

Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus
PNAS 2005 102: 14994-14999; published online before print October 7 2005, 10.1073/pnas.0506254102 [Abstract] [Full Text] [Figures Only] [PDF]  

Julia Gorelik, Yanjun Zhang, Daniel Sánchez, Andrew Shevchuk, Gregory Frolenkov, Max Lab, David Klenerman, Christopher Edwards, and Yuri Korchev

Aldosterone acts via an ATP autocrine/paracrine system: The Edelman ATP hypothesis revisited
PNAS 2005 102: 15000-15005; published online before print October 17 2005, 10.1073/pnas.0507008102 [Abstract] [Full Text] [Figures Only] [PDF]  

Gareth M. Thomas, Gavin R. Rumbaugh, Dana B. Harrar, and Richard L. Huganir

Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission
PNAS 2005 102: 15006-15011; published online before print October 10 2005, 10.1073/pnas.0507476102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Milind C. Mahajan, Geeta J. Narlikar, Gokul Boyapaty, Robert E. Kingston, and Sherman M. Weissman

Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the -globin locus control region
PNAS 2005 102: 15012-15017; published online before print October 10 2005, 10.1073/pnas.0507596102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ekaterina I. Biterova, Anton A. Turanov, Vadim N. Gladyshev, and Joseph J. Barycki

Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism
PNAS 2005 102: 15018-15023; published online before print October 10 2005, 10.1073/pnas.0504218102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Samuel Bouyain, Patti A. Longo, Shiqing Li, Kathryn M. Ferguson, and Daniel J. Leahy

The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
PNAS 2005 102: 15024-15029; published online before print October 3 2005, 10.1073/pnas.0507591102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Supporting Information]  

Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V. Davydov, and Yong Tae Kwon

RGS4 and RGS5 are in vivo substrates of the N-end rule pathway
PNAS 2005 102: 15030-15035; published online before print October 10 2005, 10.1073/pnas.0507533102 [Abstract] [Full Text] [Figures Only] [PDF]  

Murali Palangat, Dan B. Renner, David H. Price, and Robert Landick

A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS
PNAS 2005 102: 15036-15041; published online before print October 7 2005, 10.1073/pnas.0409405102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Jeremy R. Sanford, Jonathan D. Ellis, Demian Cazalla, and Javier F. Cáceres

Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor
PNAS 2005 102: 15042-15047; published online before print October 6 2005, 10.1073/pnas.0507827102 [Abstract] [Full Text] [Figures Only] [PDF]  

Korry J. Hintze and Elizabeth C. Theil

DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression
PNAS 2005 102: 15048-15052; published online before print October 10 2005, 10.1073/pnas.0505148102 [Abstract] [Full Text] [Figures Only] [PDF]  

Stefan Gazdoiu, Kosj Yamoah, Kenneth Wu, Carlos R. Escalante, Inger Tappin, Vladimir Bermudez, Aneel K. Aggarwal, Jerard Hurwitz, and Zhen-Qiang Pan Proximity-induced activation of human Cdc34 through heterologous dimerization PNAS 2005 102: 15053-15058; published online before print October 6 2005, 10.1073/pnas.0507646102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Biophysics

Matthew Auton and D. Wayne Bolen

Predicting the energetics of osmolyte-induced protein folding/unfolding
PNAS 2005 102: 15065-15068; published online before print October 7 2005, 10.1073/pnas.0507053102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ananya Mitra, Gisela D. Cymes, and Anthony Auerbach

Dynamics of the acetylcholine receptor pore at the gating transition state
PNAS 2005 102: 15069-15074; published online before print October 10 2005, 10.1073/pnas.0505090102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Vladimir A. Karginov, Ekaterina M. Nestorovich, Mahtab Moayeri, Stephen H. Leppla, and Sergey M. Bezrukov

Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design
PNAS 2005 102: 15075-15080; published online before print October 7 2005, 10.1073/pnas.0507488102 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Bharath Ananthanarayanan, Qiang Ni, and Jin Zhang

Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity
PNAS 2005 102: 15081-15086; published online before print October 7 2005, 10.1073/pnas.0502889102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yoshiyuki Wakabayashi, Parmesh Dutt, Jennifer Lippincott-Schwartz, and Irwin M. Arias

Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells
PNAS 2005 102: 15087-15092; published online before print October 7 2005, 10.1073/pnas.0503702102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yoshihiro Nakatani, Hiroaki Konishi, Alex Vassilev, Hisanori Kurooka, Keiichiro Ishiguro, Jun-ichi Sawada, Tsuyoshi Ikura, Stanley J. Korsmeyer, Jun Qin, and Anna M. Herlitz From the Cover: p600, a unique protein required for membrane morphogenesis and cell survival PNAS 2005 102: 15093-15098; published online before print October 7 2005, 10.1073/pnas.0507458102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Harald Bär, Norbert Mücke, Anna Kostareva, Gunnar Sjöberg, Ueli Aebi, and Harald Herrmann Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages PNAS 2005 102: 15099-15104; published online before print October 10 2005, 10.1073/pnas.0504568102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Shiaw-Yih Lin, Rekha Rai, Kaiyi Li, Zhi-Xiang Xu, and Stephen J. Elledge

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly
PNAS 2005 102: 15105-15109; published online before print October 10 2005, 10.1073/pnas.0507722102 [Abstract] [Full Text] [Figures Only] [PDF]  

Helge Ewers, Alicia E. Smith, Ivo F. Sbalzarini, Hauke Lilie, Petros Koumoutsakos, and Ari Helenius

Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes
PNAS 2005 102: 15110-15115; published online before print October 11 2005, 10.1073/pnas.0504407102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kohtaro Minami, Masaaki Okuno, Kazumasa Miyawaki, Akinori Okumachi, Katsuhiko Ishizaki, Kazunobu Oyama, Miho Kawaguchi, Nobuko Ishizuka, Toshihiko Iwanaga, and Susumu Seino

Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells
PNAS 2005 102: 15116-15121; published online before print October 6 2005, 10.1073/pnas.0507567102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Jiyeon Oh, James A. Richardson, and Eric N. Olson

Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation
PNAS 2005 102: 15122-15127; published online before print October 4 2005, 10.1073/pnas.0507346102 [Abstract] [Full Text] [Figures Only] [PDF]  

Julie Batut, Laurence Vandel, Catherine Leclerc, Christiane Daguzan, Marc Moreau, and Isabelle Néant

The Ca²+-induced methyltransferase xPRMT1b controls neural fate in amphibian embryo
PNAS 2005 102: 15128-15133; published online before print October 7 2005, 10.1073/pnas.0502483102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Yasunori Sasakura, Keisuke Nakashima, Satoko Awazu, Terumi Matsuoka, Akie Nakayama, Jun-ichi Azuma, and Nori Satoh

Transposon-mediated insertional mutagenesis revealed the functions of animal cellulose synthase in the ascidian Ciona intestinalis
PNAS 2005 102: 15134-15139; published online before print October 7 2005, 10.1073/pnas.0503640102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

Jonathan J. Ryder, K. Mary Webberley, Michael Boots, and Robert J. Knell

Measuring the transmission dynamics of a sexually transmitted disease
PNAS 2005 102: 15140-15143; published online before print October 4 2005, 10.1073/pnas.0505139102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Environmental Sciences

Evolution

Robert R. Jackson, Ximena J. Nelson, and Godfrey O. Sune

A spider that feeds indirectly on vertebrate blood by choosing female mosquitoes as prey
PNAS 2005 102: 15155-15160; published online before print October 10 2005, 10.1073/pnas.0507398102 [Abstract] [Full Text] [Figures Only] [PDF]  

Nicola J. Nasser, Eviatar Nevo, Itay Shafat, Neta Ilan, Israel Vlodavsky, and Aaron Avivi

Adaptive evolution of heparanase in hypoxia-tolerant Spalax: Gene cloning and identification of a unique splice variant
PNAS 2005 102: 15161-15166; published online before print October 4 2005, 10.1073/pnas.0507279102 [Abstract] [Full Text] [Figures Only] [PDF]  

Genetics

Xiaolin Bi, Deepa Srikanta, Laura Fanti, Sergio Pimpinelli, RamaKrishna Badugu, Rebecca Kellum, and Yikang S. Rong

Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance
PNAS 2005 102: 15167-15172; published online before print October 3 2005, 10.1073/pnas.0504981102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Courtney T. Griffin, JoAnn Trejo, and Terry Magnuson

Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2
PNAS 2005 102: 15173-15177; published online before print October 7 2005, 10.1073/pnas.0409558102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Norihito Yazawa, Yasuhito Hamaguchi, Jonathan C. Poe, and Thomas F. Tedder

Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease
PNAS 2005 102: 15178-15183; published online before print October 10 2005, 10.1073/pnas.0505539102 [Abstract] [Full Text] [Figures Only] [PDF]  

Daniel R. Johnson, Jason C. O'Connor, Robert Dantzer, and Gregory G. Freund

Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness
PNAS 2005 102: 15184-15189; published online before print October 10 2005, 10.1073/pnas.0507191102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ulrike Wille-Reece, Barbara J. Flynn, Karin Loré, Richard A. Koup, Ross M. Kedl, Joseph J. Mattapallil, Walter R. Weiss, Mario Roederer, and Robert A. Seder

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8⁺ T cell responses in nonhuman primates
PNAS 2005 102: 15190-15194; published online before print October 11 2005, 10.1073/pnas.0507484102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Medical Sciences

Yanping Zhang, Wenxue Tang, Shoab Ahmad, James A. Sipp, Ping Chen, and Xi Lin

Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions
PNAS 2005 102: 15201-15206; published online before print October 10 2005, 10.1073/pnas.0501859102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thomas Ho-Yin Leung, Yick-Pang Ching, Judy Wai Ping Yam, Chun-Ming Wong, Tai-On Yau, Dong-Yan Jin, and Irene Oi-Lin Ng Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity PNAS 2005 102: 15207-15212; published online before print October 10 2005, 10.1073/pnas.0504501102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Ryu-ichi Fukuda, Ayako Hayashi, Atae Utsunomiya, Yuko Nukada, Rie Fukui, Katsuhiko Itoh, Katsunari Tezuka, Kazumasa Ohashi, Kensaku Mizuno, Manabu Sakamoto, Masahiro Hamanoue, and Takashi Tsuji

Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)
PNAS 2005 102: 15213-15218; published online before print October 10 2005, 10.1073/pnas.0507184102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

D. Ragozzino, E. Palma, S. Di Angelantonio, M. Amici, A. Mascia, A. Arcella, F. Giangaspero, G. Cantore, G. Di Gennaro, M. Manfredi, V. Esposito, P. P. Quarato, R. Miledi, and F. Eusebi

Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy
PNAS 2005 102: 15219-15223; published online before print October 10 2005, 10.1073/pnas.0507339102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Amy K. Y. Fu, Fanny C. F. Ip, Wing-Yu Fu, Janet Cheung, Jerry H. Wang, Wing-Ho Yung, and Nancy Y. Ip

Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice
PNAS 2005 102: 15224-15230; published online before print October 3 2005, 10.1073/pnas.0507678102 [Abstract] [Full Text] [Figures Only] [PDF]  

Chay T. Kuo, Lily Y. Jan, and Yuh Nung Jan Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling PNAS 2005 102: 15230-15235; published online before print October 6 2005, 10.1073/pnas.0507393102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

J. Gotman, C. Grova, A. Bagshaw, E. Kobayashi, Y. Aghakhani, and F. Dubeau

Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain
PNAS 2005 102: 15236-15240; published online before print October 10 2005, 10.1073/pnas.0504935102 [Abstract] [Full Text] [Figures Only] [PDF]  

Physiology

Hana Cho, Yeon A. Kim, Jin-Young Yoon, Doyun Lee, Jae Ho Kim, Suk Ho Lee, and Won-Kyung Ho

Low mobility of phosphatidylinositol 4,5-bisphosphate underlies receptor specificity of Gq-mediated ion channel regulation in atrial myocytes
PNAS 2005 102: 15241-15246; published online before print October 10 2005, 10.1073/pnas.0408851102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mari Leppilampi, Seppo Parkkila, Tuomo Karttunen, Marta Ortova Gut, Gerolf Gros, and Markus Sjöblom

Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E₂
PNAS 2005 102: 15247-15252; published online before print October 10 2005, 10.1073/pnas.0508007102 [Abstract] [Full Text] [Figures Only] [PDF]  

Plant Biology

Population Biology

Derek A. T. Cummings, Ira B. Schwartz, Lora Billings, Leah B. Shaw, and Donald S. Burke

Dynamic effects of antibody-dependent enhancement on the fitness of viruses
PNAS 2005 102: 15259-15264; published online before print October 10 2005, 10.1073/pnas.0507320102 [Abstract] [Full Text] [Figures Only] [PDF]  

João A. N. Filipe, Michel Boussinesq, Alfons Renz, Richard C. Collins, Sarai Vivas-Martinez, María-Eugenia Grillet, Mark P. Little, and María-Gloria Basáñez

Human infection patterns and heterogeneous exposure in river blindness
PNAS 2005 102: 15265-15270; published online before print October 10 2005, 10.1073/pnas.0502659102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]