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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 15713-15714. [Full Text] [PDF]  

FROM THE ACADEMY

William A. Jury and Henry Vaux, Jr

Colloquium Perspective: The role of science in solving the world's emerging water problems
PNAS 2005 102: 15715-15720; published online before print October 25 2005, 10.1073/pnas.0506467102 [Extract] [Full Text] [PDF]  

COMMENTARIES

Harry Schachter

The search for glycan function: Fucosylation of the TGF-1 receptor is required for receptor activation
PNAS 2005 102: 15721-15722; published online before print October 25 2005, 10.1073/pnas.0507659102 [Extract] [Full Text] [PDF]  
See companion article on page 15791

Jack H. Kaplan

The sodium pump and hypertension: A physiological role for the cardiac glycoside binding site of the Na,K-ATPase
PNAS 2005 102: 15723-15724; published online before print October 24 2005, 10.1073/pnas.0507965102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 15845

PROFILES

Regina Nuzzo

Profile of Stephen H. Schneider
PNAS 2005 102: 15725-15727; published online before print October 25 2005, 10.1073/pnas.0507327102 [Extract] [Full Text] [Figures Only] [PDF]  

Nick Zagorski

Profile of Deborah P. Delmer
PNAS 2005 102: 15736-15738; published online before print October 25 2005, 10.1073/pnas.0506847102 [Extract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Mathematics

Simone Pigolotti, Alessandro Flammini, Matteo Marsili, and Amos Maritan

Species lifetime distribution for simple models of ecologies
PNAS 2005 102: 15747-15751; published online before print October 18 2005, 10.1073/pnas.0502648102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Applied Physical Sciences

Haifeng Wang, Terry B. Huff, Daniel A. Zweifel, Wei He, Philip S. Low, Alexander Wei, and Ji-Xin Cheng

In vitro and in vivo two-photon luminescence imaging of single gold nanorods
PNAS 2005 102: 15752-15756; published online before print October 20 2005, 10.1073/pnas.0504892102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

Xiaoyuan Hu, Paul H. Bessette, Jiangrong Qian, Carl D. Meinhart, Patrick S. Daugherty, and Hyongsok T. Soh

Marker-specific sorting of rare cells using dielectrophoresis
PNAS 2005 102: 15757-15761; published online before print October 18 2005, 10.1073/pnas.0507719102 [Abstract] [Full Text] [Figures Only] [PDF]  

Chemistry

M. A. Kamboures, D. R. Blake, D. M. Cooper, R. L. Newcomb, M. Barker, J. K. Larson, S. Meinardi, E. Nussbaum, and F. S. Rowland

Breath sulfides and pulmonary function in cystic fibrosis
PNAS 2005 102: 15762-15767; published online before print October 24 2005, 10.1073/pnas.0507263102 [Abstract] [Full Text] [Figures Only] [PDF]  

Environmental Sciences

K. P. Shine, T. K. Berntsen, J. S. Fuglestvedt, and R. Sausen

Scientific issues in the design of metrics for inclusion of oxides of nitrogen in global climate agreements
PNAS 2005 102: 15768-15773; published online before print October 21 2005, 10.1073/pnas.0506865102 [Abstract] [Full Text] [Figures Only] [PDF]  

Geophysics

Noah S. Diffenbaugh, Jeremy S. Pal, Robert J. Trapp, and Filippo Giorgi

Fine-scale processes regulate the response of extreme events to global climate change
PNAS 2005 102: 15774-15778; published online before print October 19 2005, 10.1073/pnas.0506042102 [Abstract] [Full Text] [Figures Only] [PDF]  

BIOLOGICAL SCIENCES

Agricultural Sciences

Applied Biological Sciences

Cara-Lynn E. Helm, Mark E. Fleury, Andreas H. Zisch, Federica Boschetti, and Melody A. Swartz

Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism
PNAS 2005 102: 15779-15784; published online before print October 25 2005, 10.1073/pnas.0503681102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mathias Ehrich, Matthew R. Nelson, Patrick Stanssens, Marc Zabeau, Triantafillos Liloglou, George Xinarianos, Charles R. Cantor, John K. Field, and Dirk van den Boom

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry
PNAS 2005 102: 15785-15790; published online before print October 21 2005, 10.1073/pnas.0507816102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

Saulius Grazulis, Elena Manakova, Manfred Roessle, Matthias Bochtler, Giedre Tamulaitiene, Robert Huber, and Virginijus Siksnys Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease PNAS 2005 102: 15797-15802; published online before print October 24 2005, 10.1073/pnas.0507949102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Tae Woo Kim, James C. Delaney, John M. Essigmann, and Eric T. Kool

Probing the active site tightness of DNA polymerase in subangstrom increments
PNAS 2005 102: 15803-15808; published online before print October 25 2005, 10.1073/pnas.0505113102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Guangtao Li, Xiaoke Zhou, Gang Zhao, Hermann Schindelin, and William J. Lennarz

Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome
PNAS 2005 102: 15809-15814; published online before print October 25 2005, 10.1073/pnas.0507155102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jun Yin, Paul D. Straight, Shaun M. McLoughlin, Zhe Zhou, Alison J. Lin, David E. Golan, Neil L. Kelleher, Roberto Kolter, and Christopher T. Walsh

Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase
PNAS 2005 102: 15815-15820; published online before print October 19 2005, 10.1073/pnas.0507705102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Alan M. Roseman, John A. Berriman, Samantha A. Wynne, P. Jonathan G. Butler, and R. Anthony Crowther

A structural model for maturation of the hepatitis B virus core
PNAS 2005 102: 15821-15826; published online before print October 24 2005, 10.1073/pnas.0504874102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Karolien De Bosscher, Wim Vanden Berghe, Ilse M. E. Beck, Wim Van Molle, Nathalie Hennuyer, Janet Hapgood, Claude Libert, Bart Staels, Ann Louw, and Guy Haegeman

A fully dissociated compound of plant origin for inflammatory gene repression
PNAS 2005 102: 15827-15832; published online before print October 21 2005, 10.1073/pnas.0505554102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

M. Jáchymová, P. Martásek, S. Panda, L. J. Roman, M. Panda, T. M. Shea, Y. Ishimura, J.-J. P. Kim, and B. S. S. Masters

Recruitment of governing elements for electron transfer in the nitric oxide synthase family
PNAS 2005 102: 15833-15838; published online before print October 25 2005, 10.1073/pnas.0506522102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kate J. Newberry, Shunji Nakano, Peter Zuber, and Richard G. Brennan Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the C-terminal domain of RNA polymerase PNAS 2005 102: 15839-15844; published online before print October 25 2005, 10.1073/pnas.0506592102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE

Iva Dostanic-Larson, James W. Van Huysse, John N. Lorenz, and Jerry B Lingrel From The Cover: The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation PNAS 2005 102: 15845-15850; published online before print October 21 2005, 10.1073/pnas.0507358102 [Abstract] [Full Text] [Figures Only] [PDF]   See Commentary on page 15723

Biophysics

A. S. Fokas, T. S. Papatheodorou, A. E. Kister, and I. M. Gelfand

A geometric construction determines all permissible strand arrangements of sandwich proteins
PNAS 2005 102: 15851-15853; published online before print October 25 2005, 10.1073/pnas.0507335102 [Abstract] [Full Text] [Figures Only] [PDF]  

Kevin Y. Sanbonmatsu, Simpson Joseph, and Chang-Shung Tung Simulating movement of tRNA into the ribosome during decoding PNAS 2005 102: 15854-15859; published online before print October 25 2005, 10.1073/pnas.0503456102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Jean Alric, Yves Pierre, Daniel Picot, Jérôme Lavergne, and Fabrice Rappaport

Spectral and redox characterization of the heme c_i of the cytochrome b₆f complex
PNAS 2005 102: 15860-15865; published online before print October 24 2005, 10.1073/pnas.0508102102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

A. Ghetta, D. Prosperi, F. Mantegazza, L. Panza, S. Riva, and T. Bellini

Light scattered by model phantom bacteria reveals molecular interactions at their surface
PNAS 2005 102: 15866-15870; published online before print October 21 2005, 10.1073/pnas.0505877102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Henrike Heise, Wolfgang Hoyer, Stefan Becker, Ovidiu C. Andronesi, Dietmar Riedel, and Marc Baldus

Molecular-level secondary structure, polymorphism, and dynamics of full-length -synuclein fibrils studied by solid-state NMR
PNAS 2005 102: 15871-15876; published online before print October 24 2005, 10.1073/pnas.0506109102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yoav Paas, Gilad Gibor, Regis Grailhe, Nathalie Savatier-Duclert, Virginie Dufresne, Morten Sunesen, Lia Prado de Carvalho, Jean-Pierre Changeux, and Bernard Attali

Pore conformations and gating mechanism of a Cys-loop receptor
PNAS 2005 102: 15877-15882; published online before print October 24 2005, 10.1073/pnas.0507599102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Darren M. Gowers, Geoffrey G. Wilson, and Stephen E. Halford From The Cover: Measurement of the contributions of 1D and 3D pathways to the translocation of a protein along DNA PNAS 2005 102: 15883-15888; published online before print October 21 2005, 10.1073/pnas.0505378102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE   See Commentary on page 16909

Cell Biology

Daniela Nicastro, J. Richard McIntosh, and Wolfgang Baumeister

3D structure of eukaryotic flagella in a quiescent state revealed by cryo-electron tomography
PNAS 2005 102: 15889-15894; published online before print October 24 2005, 10.1073/pnas.0508274102 [Abstract] [Full Text] [Figures Only] [PDF]  

Roland Kaunas, Phu Nguyen, Shunichi Usami, and Shu Chien From The Cover: Cooperative effects of Rho and mechanical stretch on stress fiber organization PNAS 2005 102: 15895-15900; published online before print October 24 2005, 10.1073/pnas.0506041102 [Abstract] [Full Text] [Figures Only] [PDF]

Edward Htun van der Horst, Yan Y. Degenhardt, Astrid Strelow, Anthony Slavin, Lawrence Chinn, Jessica Orf, Minqing Rong, Shyun Li, Lei-Hoon See, Ken Q. C. Nguyen, Timothy Hoey, Holger Wesche, and Scott Powers

Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1
PNAS 2005 102: 15901-15906; published online before print October 24 2005, 10.1073/pnas.0508014102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Developmental Biology

Frédéric Biemar, Robert Zinzen, Matthew Ronshaugen, Victor Sementchenko, J. Robert Manak, and Michael S. Levine

Spatial regulation of microRNA gene expression in the Drosophila embryo
PNAS 2005 102: 15907-15911; published online before print October 25 2005, 10.1073/pnas.0507817102 [Abstract] [Full Text] [Figures Only] [PDF]  

Rebecca M. Robich and David L. Denlinger

Diapause in the mosquito Culex pipiens evokes a metabolic switch from blood feeding to sugar gluttony
PNAS 2005 102: 15912-15917; published online before print October 24 2005, 10.1073/pnas.0507958102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Tomonori Katsuyama, Tomo Sugawara, Masanobu Tatsumi, Yoshiteru Oshima, Walter J. Gehring, Toshiro Aigaki, and Shoichiro Kurata

Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification
PNAS 2005 102: 15918-15923; published online before print October 24 2005, 10.1073/pnas.0507945102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Evolution

Johannes Sikorski and Eviatar Nevo

Adaptation and incipient sympatric speciation of Bacillus simplex under microclimatic contrast at "Evolution Canyons" I and II, Israel
PNAS 2005 102: 15924-15929; published online before print October 25 2005, 10.1073/pnas.0507944102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Aram D. Stump, Meagan C. Fitzpatrick, Neil F. Lobo, Sékou Traoré, N'Fale Sagnon, Carlo Costantini, Frank H. Collins, and Nora J. Besansky

Centromere-proximal differentiation and speciation in Anopheles gambiae
PNAS 2005 102: 15930-15935; published online before print October 24 2005, 10.1073/pnas.0508161102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Ville Mustonen and Michael Lässig

Evolutionary population genetics of promoters: Predicting binding sites and functional phylogenies
PNAS 2005 102: 15936-15941; published online before print October 19 2005, 10.1073/pnas.0505537102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sohini Ramachandran, Omkar Deshpande, Charles C. Roseman, Noah A. Rosenberg, Marcus W. Feldman, and L. Luca Cavalli-Sforza

Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa
PNAS 2005 102: 15942-15947; published online before print October 21 2005, 10.1073/pnas.0507611102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Esther P. Black, Timothy Hallstrom, Holly K. Dressman, Mike West, and Joseph R. Nevins

Distinctions in the specificity of E2F function revealed by gene expression signatures
PNAS 2005 102: 15948-15953; published online before print October 25 2005, 10.1073/pnas.0504300102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hengshan Zhang and Christopher W. Lawrence

The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination
PNAS 2005 102: 15954-15959; published online before print October 24 2005, 10.1073/pnas.0504586102 [Abstract] [Full Text] [Figures Only] [PDF]  

Mary Armanios, Jiunn-Liang Chen, Yen-Pei Christy Chang, Robert A. Brodsky, Anita Hawkins, Constance A. Griffin, James R. Eshleman, Alan R. Cohen, Aravinda Chakravarti, Ada Hamosh, and Carol W. Greider

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita
PNAS 2005 102: 15960-15964; published online before print October 24 2005, 10.1073/pnas.0508124102 [Abstract] [Full Text] [Figures Only] [PDF]  

Justin P. Blumenstiel and Daniel L. Hartl

Evidence for maternally transmitted small interfering RNA in the repression of transposition in Drosophila virilis
PNAS 2005 102: 15965-15970; published online before print October 24 2005, 10.1073/pnas.0508192102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Mitsuhiro Itaya, Kenji Tsuge, Maki Koizumi, and Kyoko Fujita From The Cover: Combining two genomes in one cell: Stable cloning of the Synechocystis PCC6803 genome in the Bacillus subtilis 168 genome PNAS 2005 102: 15971-15976; published online before print October 18 2005, 10.1073/pnas.0503868102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Qiutang Li, Qingxian Lu, Gabriela Estepa, and Inder M. Verma

Identification of 14-3-3 mutation causing cutaneous abnormality in repeated-epilation mutant mouse
PNAS 2005 102: 15977-15982; published online before print October 20 2005, 10.1073/pnas.0508310102 [Abstract] [Full Text] [Figures Only] [PDF]  

S. Yamamoto, I. Yoshino, T. Shimazaki, M. Murohashi, R. F. Hevner, I. Lax, H. Okano, M. Shibuya, J. Schlessinger, and N. Gotoh

Essential role of Shp2-binding sites on FRS2 for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells
PNAS 2005 102: 15983-15988; published online before print October 20 2005, 10.1073/pnas.0507961102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Materials and Methods]  

Immunology

Li-Fen Lee, Baohui Xu, Sara A. Michie, Georg F. Beilhack, Tibor Warganich, Shannon Turley, and Hugh O. McDevitt

The role of TNF- in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation
PNAS 2005 102: 15995-16000; published online before print October 24 2005, 10.1073/pnas.0508122102 [Abstract] [Full Text] [Figures Only] [PDF]  

Kiri Honma, Heiichiro Udono, Tomoko Kohno, Kazuo Yamamoto, Asako Ogawa, Toshitada Takemori, Atsushi Kumatori, Shoichi Suzuki, Toshifumi Matsuyama, and Katsuyuki Yui

Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS
PNAS 2005 102: 16001-16006; published online before print October 21 2005, 10.1073/pnas.0504226102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xiangyang Dong, Ward Lutz, Tania M. Schroeder, Lori A. Bachman, Jennifer J. Westendorf, Rajiv Kumar, and Matthew D. Griffin Regulation of relB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promoter PNAS 2005 102: 16007-16012; published online before print October 20 2005, 10.1073/pnas.0506516102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Medical Sciences

Gilda M. Kalinec, Martin E. Fernandez-Zapico, Raul Urrutia, Nora Esteban-Cruciani, Shanping Chen, and Federico Kalinec

Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss
PNAS 2005 102: 16019-16024; published online before print October 20 2005, 10.1073/pnas.0508053102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Martin Kohlmeier, Kerry-Ann da Costa, Leslie M. Fischer, and Steven H. Zeisel

Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
PNAS 2005 102: 16025-16030; published online before print October 18 2005, 10.1073/pnas.0504285102 [Abstract] [Full Text] [Figures Only] [PDF]  

Annick Le Dur, Vincent Béringue, Olivier Andréoletti, Fabienne Reine, Thanh Lan Laï, Thierry Baron, Bjørn Bratberg, Jean-Luc Vilotte, Pierre Sarradin, Sylvie L. Benestad, and Hubert Laude

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes
PNAS 2005 102: 16031-16036; published online before print October 20 2005, 10.1073/pnas.0502296102 [Abstract] [Full Text] [Figures Only] [PDF]  

Microbiology

Samuel A. Shelburne, III, Paul Sumby, Izabela Sitkiewicz, Chanel Granville, Frank R. DeLeo, and James M. Musser

Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva
PNAS 2005 102: 16037-16042; published online before print October 25 2005, 10.1073/pnas.0505839102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Olivia L. Champion, Michael W. Gaunt, Ozan Gundogdu, Abdi Elmi, Adam A. Witney, Jason Hinds, Nick Dorrell, and Brendan W. Wren

Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source
PNAS 2005 102: 16043-16048; published online before print October 17 2005, 10.1073/pnas.0503252102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Andreas Sing, Dagmar Reithmeier-Rost, Kaisa Granfors, Jim Hill, Andreas Roggenkamp, and Jürgen Heesemann

A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence
PNAS 2005 102: 16049-16054; published online before print October 20 2005, 10.1073/pnas.0504728102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Qing-Yin Wang, Changhong Zhou, Karen E. Johnson, Robert C. Colgrove, Donald M. Coen, and David M. Knipe Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection PNAS 2005 102: 16055-16059; published online before print October 24 2005, 10.1073/pnas.0505850102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Neuroscience

Xenia Protopopescu, Hong Pan, Margaret Altemus, Oliver Tuescher, Margaret Polanecsky, Bruce McEwen, David Silbersweig, and Emily Stern

Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle
PNAS 2005 102: 16060-16065; published online before print October 24 2005, 10.1073/pnas.0502818102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yoko Matsuoka, Tomoyuki Furuyashiki, Kiyofumi Yamada, Taku Nagai, Haruhiko Bito, Yasuhiro Tanaka, Shiho Kitaoka, Fumitaka Ushikubi, Toshitaka Nabeshima, and Shuh Narumiya

Prostaglandin E receptor EP1 controls impulsive behavior under stress
PNAS 2005 102: 16066-16071; published online before print October 24 2005, 10.1073/pnas.0504908102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Dong-Hyuk Jang, Jin-Hee Han, Seung-Hee Lee, Yong-Seok Lee, Hyungju Park, Sue-Hyun Lee, Hyoung Kim, and Bong-Kiun Kaang

Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses
PNAS 2005 102: 16072-16077; published online before print October 24 2005, 10.1073/pnas.0507675102 [Abstract] [Full Text] [Figures Only] [PDF]  

Pharmacology

James G. Conway, Brad McDonald, Janet Parham, Barry Keith, David W. Rusnak, Eva Shaw, Marilyn Jansen, Peiyuan Lin, Alan Payne, Renae M. Crosby, Jennifer H. Johnson, Lloyd Frick, Min-Hwa Jasmine Lin, Scott Depee, Sarva Tadepalli, Bart Votta, Ian James, Karen Fuller, Timothy J. Chambers, Frederick C. Kull, Stanley D. Chamberlain, and Jeff T. Hutchins

Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580
PNAS 2005 102: 16078-16083; published online before print October 25 2005, 10.1073/pnas.0502000102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marián Castro, Viacheslav O. Nikolaev, Dieter Palm, Martin J. Lohse, and Jean-Pierre Vilardaga

Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism
PNAS 2005 102: 16084-16089; published online before print October 18 2005, 10.1073/pnas.0503942102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yan Zhao, Jing Tan, Li Zhuang, Xia Jiang, Edison T. Liu, and Qiang Yu

Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
PNAS 2005 102: 16090-16095; published online before print October 21 2005, 10.1073/pnas.0505585102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Physiology

Yuki Takayanagi, Masahide Yoshida, Isadora F. Bielsky, Heather E. Ross, Masaki Kawamata, Tatsushi Onaka, Teruyuki Yanagisawa, Tadashi Kimura, Martin M. Matzuk, Larry J. Young, and Katsuhiko Nishimori

Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
PNAS 2005 102: 16096-16101; published online before print October 25 2005, 10.1073/pnas.0505312102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael J. Morton, Abdulrahman Abohamed, Asipu Sivaprasadarao, and Malcolm Hunter

pH sensing in the two-pore domain K⁺ channel, TASK2
PNAS 2005 102: 16102-16106; published online before print October 20 2005, 10.1073/pnas.0506870102 [Abstract] [Full Text] [Figures Only] [PDF]  

Plant Biology

Toshio Yamaguchi, Gilad S. Aharon, Jordan B. Sottosanto, and Eduardo Blumwald

Vacuolar Na⁺/H⁺ antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca²⁺- and pH-dependent manner
PNAS 2005 102: 16107-16112; published online before print October 25 2005, 10.1073/pnas.0504437102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Etienne H. Meyer, Philippe Giegé, Eric Gelhaye, Naganand Rayapuram, Umesh Ahuja, Linda Thöny-Meyer, Jean-Michel Grienenberger, and Géraldine Bonnard

AtCCMH, an essential component of the c-type cytochrome maturation pathway in Arabidopsis mitochondria, interacts with apocytochrome c
PNAS 2005 102: 16113-16118; published online before print October 18 2005, 10.1073/pnas.0503473102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

CORRECTIONS

Correction for Johannessen et al., The NF1 tumor suppressor critically regulates TSC2 and mTOR, PNAS 2005 102:8573-8578 [Extract] [Full Text] [PDF]  

Correction for Aslan et al., Engineered single-chain dimeric streptavidins with an unexpected strong preference for biotin-4-fluorescein, PNAS 2005 102:8507-8512 [Extract] [Full Text] [PDF]  

Correction for Wilson et al., Eusociality: Origin and consequences, PNAS 2005 102:13367-13371 [Extract] [Full Text] [PDF]  

Correction for Nishimura et al., Descent of the larynx in chimpanzee infants, PNAS 2003 100:6930-6933 [Extract] [Full Text] [Figures Only] [PDF]