Cover illustration

November 1, 2005; 102 (44)
Cover image expansion

Cover image: Actin stress fibers (red) orient perpendicular to the direction of cyclic stretch (horizontal) in arterial endothelial cells with normal Rho activity. Cell borders are indicated by β-catenin staining (green). The Rho pathway plays a major role in determining the direction and extent of stretch-induced stress fiber orientation. See the article by Kaunas et al. on pages 15895–15900. Image courtesy of Roland Kaunas and Shu Chien.