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Table of Contents

December 20, 2005; 102 (51)  [Index By Author]  [Cover Photo]  [Masthead (PDF)]

FROM THE COVER

Enzymatic rescue of myelination

Creating DNA nanostrand arrays

Myocardial growth via retinoid receptor

Allosteric site activation in stress

Gravisensing in winding plants

IN THIS ISSUE

COMMENTARIES

PROFILES

PHYSICAL SCIENCES
    Applied Physical Sciences
    Chemistry
    Environmental Sciences
    Geophysics
    Statistics

SOCIAL SCIENCES
    Anthropology
    Psychology

BIOLOGICAL SCIENCES
    Agricultural Sciences
    Anthropology
    Applied Biological Sciences
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Ecology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Physiology
    Plant Biology
    Psychology

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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 18243-18244. [Full Text] [PDF]  

COMMENTARIES

Christian Hansel
When the B-team runs plasticity: GluR2 receptor trafficking in cerebellar long-term potentiation
PNAS 2005 102: 18245-18246; published online before print December 12 2005, 10.1073/pnas.0509686102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 17846 in issue 49 of volume 102

C. Sue Carter
The chemistry of child neglect: Do oxytocin and vasopressin mediate the effects of early experience?
PNAS 2005 102: 18247-18248; published online before print December 12 2005, 10.1073/pnas.0509376102 [Extract] [Full Text] [PDF]  
See companion article on page 17237 in issue 47 of volume 102

PROFILES

Nick Zagorski
Profile of Raymond C. Kelly
PNAS 2005 102: 18249-18251; published online before print December 13 2005, 10.1073/pnas.0506968102 [Extract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Applied Physical Sciences

Giannis Zacharakis, Hirokazu Kambara, Helen Shih, Jorge Ripoll, Jan Grimm, Yoshinaga Saeki, Ralph Weissleder, and Vasilis Ntziachristos
Volumetric tomography of fluorescent proteins through small animals in vivo
PNAS 2005 102: 18252-18257; published online before print December 12 2005, 10.1073/pnas.0504628102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Luis Cruz, Brigita Urbanc, Jose M. Borreguero, Noel D. Lazo, David B. Teplow, and H. Eugene Stanley
Solvent and mutation effects on the nucleation of amyloid {beta}-protein folding
PNAS 2005 102: 18258-18263; published online before print December 9 2005, 10.1073/pnas.0509276102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chemistry

Young Jik Kwon, Edward James, Nilabh Shastri, and Jean M. J. Fréchet
In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles
PNAS 2005 102: 18264-18268; published online before print December 12 2005, 10.1073/pnas.0509541102 [Abstract] [Full Text] [Figures Only] [PDF]  

Fuyi Wang, Abraha Habtemariam, Erwin P. L. van der Geer, Rafael Fernández, Michael Melchart, Robert J. Deeth, Rhona Aird, Sylvie Guichard, Francesca P. A. Fabbiani, Patricia Lozano-Casal, Iain D. H. Oswald, Duncan I. Jodrell, Simon Parsons, and Peter J. Sadler
Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity
PNAS 2005 102: 18269-18274; published online before print December 13 2005, 10.1073/pnas.0505798102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Galina E. Pavlovskaya, Zackary I. Cleveland, Karl F. Stupic, Randall J. Basaraba, and Thomas Meersmann
Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging
PNAS 2005 102: 18275-18279; published online before print December 12 2005, 10.1073/pnas.0509419102 [Abstract] [Full Text] [Figures Only] [PDF]  

Wenfeng Zhu, Andrew C. Marr, Qiang Wang, Frank Neese, Douglas J. E. Spencer, Alexander J. Blake, Paul A. Cooke, Claire Wilson, and Martin Schröder
Modulation of the electronic structure and the Ni–Fe distance in heterobimetallic models for the active site in [NiFe]hydrogenase
PNAS 2005 102: 18280-18285; published online before print December 13 2005, 10.1073/pnas.0505779102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hiroaki Gouda, Toshiaki Sunazuka, Hideaki Ui, Masaki Handa, Yusuke Sakoh, Yuzuru Iwai, Shuichi Hirono, and Satoshi Omura
Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method
PNAS 2005 102: 18286-18291; published online before print December 12 2005, 10.1073/pnas.0508425102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Environmental Sciences

H. C. Tung, N. E. Bramall, and P. B. Price
Microbial origin of excess methane in glacial ice and implications for life on Mars
PNAS 2005 102: 18292-18296; published online before print December 7 2005, 10.1073/pnas.0507601102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Geophysics

H. C. Tung, N. E. Bramall, and P. B. Price
Microbial origin of excess methane in glacial ice and implications for life on Mars
PNAS 2005 102: 18292-18296; published online before print December 7 2005, 10.1073/pnas.0507601102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Statistics

Noam Slonim, Gurinder Singh Atwal, Gasper Tkacik, and William Bialek
Information-based clustering
PNAS 2005 102: 18297-18302; published online before print December 13 2005, 10.1073/pnas.0507432102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

SOCIAL SCIENCES

Anthropology

David L. Erickson, Bruce D. Smith, Andrew C. Clarke, Daniel H. Sandweiss, and Noreen Tuross
An Asian origin for a 10,000-year-old domesticated plant in the Americas
PNAS 2005 102: 18315-18320; published online before print December 13 2005, 10.1073/pnas.0509279102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Psychology

Elliot M. Friedman, Mary S. Hayney, Gayle D. Love, Heather L. Urry, Melissa A. Rosenkranz, Richard J. Davidson, Burton H. Singer, and Carol D. Ryff
Social relationships, sleep quality, and interleukin-6 in aging women
PNAS 2005 102: 18757-18762; published online before print December 8 2005, 10.1073/pnas.0509281102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

BIOLOGICAL SCIENCES

Agricultural Sciences

Claudia Pérez, Luisa E. Fernandez, Jianguang Sun, Jorge Luis Folch, Sarjeet S. Gill, Mario Soberón, and Alejandra Bravo
Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor
PNAS 2005 102: 18303-18308; published online before print December 9 2005, 10.1073/pnas.0505494102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Supporting Information]  

Anthropology

Walter A. Neves and Mark Hubbe
Cranial morphology of early Americans from Lagoa Santa, Brazil: Implications for the settlement of the New World
PNAS 2005 102: 18309-18314; published online before print December 12 2005, 10.1073/pnas.0507185102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

David L. Erickson, Bruce D. Smith, Andrew C. Clarke, Daniel H. Sandweiss, and Noreen Tuross
An Asian origin for a 10,000-year-old domesticated plant in the Americas
PNAS 2005 102: 18315-18320; published online before print December 13 2005, 10.1073/pnas.0509279102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Applied Biological Sciences

Jingjiao Guan and L. James Lee
From the Cover: Generating highly ordered DNA nanostrand arrays
PNAS 2005 102: 18321-18325; published online before print December 13 2005, 10.1073/pnas.0506902102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Biochemistry

Michael Sacher, Alessandra Di Bacco, Vladimir V. Lunin, Zheng Ye, John Wagner, Grace Gill, and Miroslaw Cygler
The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation
PNAS 2005 102: 18326-18331; published online before print December 12 2005, 10.1073/pnas.0505071102 [Abstract] [Full Text] [Figures Only] [PDF]  

Mi Li, Gary S. Laco, Mariusz Jaskolski, Jan Rozycki, Jerry Alexandratos, Alexander Wlodawer, and Alla Gustchina
Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design
PNAS 2005 102: 18332-18337; published online before print December 13 2005, 10.1073/pnas.0509335102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

David D. Hackney
The tethered motor domain of a kinesin-microtubule complex catalyzes reversible synthesis of bound ATP
PNAS 2005 102: 18338-18343; published online before print December 9 2005, 10.1073/pnas.0505288102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Thomas A. Anderson, Matthew H. J. Cordes, and Robert T. Sauer
Sequence determinants of a conformational switch in a protein structure
PNAS 2005 102: 18344-18349; published online before print December 12 2005, 10.1073/pnas.0509349102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jennifer A. Fairley, Theodoros Kantidakis, Niall S. Kenneth, Robert V. Intine, Richard J. Maraia, and Robert J. White
Human La is found at RNA polymerase III-transcribed genes in vivo
PNAS 2005 102: 18350-18355; published online before print December 12 2005, 10.1073/pnas.0506415102 [Abstract] [Full Text] [Figures Only] [PDF]  

Xiaohua Zhang and Thomas C. Bruice
The proficiency of a thermophilic chorismate mutase enzyme is solely through an entropic advantage in the enzyme reaction
PNAS 2005 102: 18356-18360; published online before print December 12 2005, 10.1073/pnas.0509234102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Parie Garg and Peter M. Burgers
Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases {eta} and REV1
PNAS 2005 102: 18361-18366; published online before print December 12 2005, 10.1073/pnas.0505949102 [Abstract] [Full Text] [Figures Only] [PDF]  

Leslie I. Grad, Leanne C. Sayles, and Bernard D. Lemire
Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans
PNAS 2005 102: 18367-18372; published online before print December 12 2005, 10.1073/pnas.0506939102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure] OPEN ACCESS ARTICLE  

Jason G. S. Ho, Antonio Greco, Maja Rupnik, and Kenneth K.-S. Ng
Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A
PNAS 2005 102: 18373-18378; published online before print December 12 2005, 10.1073/pnas.0506391102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Jin-Shan Hu, Hanqiao Feng, Wangyong Zeng, Guang-xin Lin, and Xu Guang Xi
Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein
PNAS 2005 102: 18379-18384; published online before print December 9 2005, 10.1073/pnas.0509380102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Bing Li, Samantha G. Pattenden, Daeyoup Lee, José Gutiérrez, Jie Chen, Chris Seidel, Jennifer Gerton, and Jerry L. Workman
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling
PNAS 2005 102: 18385-18390; published online before print December 12 2005, 10.1073/pnas.0507975102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Luis Cruz, Brigita Urbanc, Jose M. Borreguero, Noel D. Lazo, David B. Teplow, and H. Eugene Stanley
Solvent and mutation effects on the nucleation of amyloid {beta}-protein folding
PNAS 2005 102: 18258-18263; published online before print December 9 2005, 10.1073/pnas.0509276102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

C. Kent Brown, Zu-Yi Gu, Yury V. Matsuka, Sai S. Purushothaman, Laurie A. Winter, P. Patrick Cleary, Stephen B. Olmsted, Douglas H. Ohlendorf, and Cathleen A. Earhart
Structure of the streptococcal cell wall C5a peptidase
PNAS 2005 102: 18391-18396; published online before print December 12 2005, 10.1073/pnas.0504954102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ekaterina V. Pletneva, Harry B. Gray, and Jay R. Winkler
Snapshots of cytochrome c folding
PNAS 2005 102: 18397-18402; published online before print December 12 2005, 10.1073/pnas.0509076102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Thomas Gregor, William Bialek, Rob R. de Ruyter van Steveninck, David W. Tank, and Eric F. Wieschaus
Diffusion and scaling during early embryonic pattern formation
PNAS 2005 102: 18403-18407; published online before print December 13 2005, 10.1073/pnas.0509483102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

J. Alejandro D'Aquino, Jaclyn Tetenbaum-Novatt, Andre White, Fred Berkovitch, and Dagmar Ringe
Mechanism of metal ion activation of the diphtheria toxin repressor DtxR
PNAS 2005 102: 18408-18413; published online before print December 13 2005, 10.1073/pnas.0500908102 [Abstract] [Full Text] [Figures Only] [PDF]  

Konstantin Klemm and Stefan Bornholdt
Topology of biological networks and reliability of information processing
PNAS 2005 102: 18414-18419; published online before print December 8 2005, 10.1073/pnas.0509132102 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Daniel H. Schott, David K. Cureton, Sean P. Whelan, and Craig P. Hunter
An antiviral role for the RNA interference machinery in Caenorhabditis elegans
PNAS 2005 102: 18420-18424; published online before print December 9 2005, 10.1073/pnas.0507123102 [Abstract] [Full Text] [Figures Only] [PDF]  

Gabrielle G. M. Pinkse, Odette H. M. Tysma, Cees A. M. Bergen, Michel G. D. Kester, Ferry Ossendorp, Peter A. van Veelen, Bart Keymeulen, Danny Pipeleers, Jan W. Drijfhout, and Bart O. Roep
Autoreactive CD8 T cells associated with {beta} cell destruction in type 1 diabetes
PNAS 2005 102: 18425-18430; published online before print December 9 2005, 10.1073/pnas.0508621102 [Abstract] [Full Text] [Figures Only] [PDF]  

Kyung Lib Jang, Julia Shackelford, So Young Seo, and Joseph S. Pagano
Up-regulation of {beta}-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells
PNAS 2005 102: 18431-18436; published online before print December 12 2005, 10.1073/pnas.0504054102 [Abstract] [Full Text] [Figures Only] [PDF]  

Izumi Horikawa, Y. Jeffrey Chiang, Tricia Patterson, Lionel Feigenbaum, Sun-Hee Leem, Eriko Michishita, Vladimir Larionov, Richard J. Hodes, and J. Carl Barrett
Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element
PNAS 2005 102: 18437-18442; published online before print December 12 2005, 10.1073/pnas.0508964102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jean J. Zhao, Zhenning Liu, Li Wang, Eyoung Shin, Massimo F. Loda, and Thomas M. Roberts
The oncogenic properties of mutant p110{alpha} and p110{beta} phosphatidylinositol 3-kinases in human mammary epithelial cells
PNAS 2005 102: 18443-18448; published online before print December 8 2005, 10.1073/pnas.0508988102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Christina Abrahamsberg, Peter Fuchs, Selma Osmanagic-Myers, Irmgard Fischer, Friedrich Propst, Adelheid Elbe-Bürger, and Gerhard Wiche
Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment
PNAS 2005 102: 18449-18454; published online before print December 12 2005, 10.1073/pnas.0505380102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Esther Merki, Mónica Zamora, Angel Raya, Yasuhiko Kawakami, Jianming Wang, Xiaoxue Zhang, John Burch, Steven W. Kubalak, Perla Kaliman, Juan Carlos Izpisua Belmonte, Kenneth R. Chien, and Pilar Ruiz-Lozano
From the Cover: Epicardial retinoid X receptor {alpha} is required for myocardial growth and coronary artery formation
PNAS 2005 102: 18455-18460; published online before print December 13 2005, 10.1073/pnas.0504343102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Zhi-jia Ye, Yuval Kluger, Zheng Lian, and Sherman M. Weissman
Two types of precursor cells in a multipotential hematopoietic cell line
PNAS 2005 102: 18461-18466; published online before print December 13 2005, 10.1073/pnas.0509314102 [Abstract] [Full Text] [Figures Only] [PDF]  

Soojin Ryu, Jochen Holzschuh, Simone Erhardt, Anne-Kathrin Ettl, and Wolfgang Driever
Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis
PNAS 2005 102: 18467-18472; published online before print December 8 2005, 10.1073/pnas.0506187102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sung-Kook Hong, Caroline E. Haldin, Nathan D. Lawson, Brant M. Weinstein, Igor B. Dawid, and Neil A. Hukriede
The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney
PNAS 2005 102: 18473-18478; published online before print December 12 2005, 10.1073/pnas.0509457102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Guillaume Junion, Teresa Jagla, Sebastien Duplant, Romain Tapin, Jean-Philippe Da Ponte, and Krzysztof Jagla
Mapping Dmef2-binding regulatory modules by using a ChIP-enriched in silico targets approach
PNAS 2005 102: 18479-18484; published online before print December 9 2005, 10.1073/pnas.0507030102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Asim S. Siddiqui, Jaswinder Khattra, Allen D. Delaney, Yongjun Zhao, Caroline Astell, Jennifer Asano, Ryan Babakaiff, Sarah Barber, Jaclyn Beland, Slavita Bohacec, Mabel Brown-John, Steve Chand, David Charest, Anita M. Charters, Rebecca Cullum, Noreen Dhalla, Ruth Featherstone, Daniela S. Gerhard, Brad Hoffman, Robert A. Holt, Juan Hou, Byron Y.-L. Kuo, Lisa L. C. Lee, Stephanie Lee, Derek Leung, Kevin Ma, Corey Matsuo, Michael Mayo, Helen McDonald, Anna-liisa Prabhu, Pawan Pandoh, Gregory J. Riggins, Teresa Ruiz de Algara, James L. Rupert, Duane Smailus, Jeff Stott, Miranda Tsai, Richard Varhol, Pavle Vrljicak, David Wong, Mona K. Wu, Yuan-Yun Xie, George Yang, Ida Zhang, Martin Hirst, Steven J. M. Jones, Cheryl D. Helgason, Elizabeth M. Simpson, Pamela A. Hoodless, and Marco A. Marra
A mouse atlas of gene expression: Large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells
PNAS 2005 102: 18485-18490; published online before print December 13 2005, 10.1073/pnas.0509455102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Ricardo M. Zayas, Alvaro Hernández, Bianca Habermann, Yuying Wang, Joel M. Stary, and Phillip A. Newmark
The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: Analysis of ESTs from the hermaphroditic strain
PNAS 2005 102: 18491-18496; published online before print December 12 2005, 10.1073/pnas.0509507102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

Taylor H. Ricketts, Eric Dinerstein, Tim Boucher, Thomas M. Brooks, Stuart H. M. Butchart, Michael Hoffmann, John F. Lamoreux, John Morrison, Mike Parr, John D. Pilgrim, Ana S. L. Rodrigues, Wes Sechrest, George E. Wallace, Ken Berlin, Jon Bielby, Neil D. Burgess, Don R. Church, Neil Cox, David Knox, Colby Loucks, Gary W. Luck, Lawrence L. Master, Robin Moore, Robin Naidoo, Robert Ridgely, George E. Schatz, Gavin Shire, Holly Strand, Wes Wettengel, and Eric Wikramanayake
Pinpointing and preventing imminent extinctions
PNAS 2005 102: 18497-18501; published online before print December 12 2005, 10.1073/pnas.0509060102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Simone Vieira, Susan Trumbore, Plinio B. Camargo, Diogo Selhorst, Jeffrey Q. Chambers, Niro Higuchi, and Luiz Antonio Martinelli
Slow growth rates of Amazonian trees: Consequences for carbon cycling
PNAS 2005 102: 18502-18507; published online before print December 9 2005, 10.1073/pnas.0505966102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table] OPEN ACCESS ARTICLE  

Evolution

Benjamin F. Voight, Alison M. Adams, Linda A. Frisse, Yudong Qian, Richard R. Hudson, and Anna Di Rienzo
Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes
PNAS 2005 102: 18508-18513; published online before print December 13 2005, 10.1073/pnas.0507325102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Simon D. W. Frost, Terri Wrin, Davey M. Smith, Sergei L. Kosakovsky Pond, Yang Liu, Ellen Paxinos, Colombe Chappey, Justin Galovich, Jeff Beauchaine, Christos J. Petropoulos, Susan J. Little, and Douglas D. Richman
Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection
PNAS 2005 102: 18514-18519; published online before print December 9 2005, 10.1073/pnas.0504658102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Genetics

Ronald Roepman, Stef J. F. Letteboer, Heleen H. Arts, Sylvia E. C. van Beersum, Xinrong Lu, Elmar Krieger, Paulo A. Ferreira, and Frans P. M. Cremers
Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations
PNAS 2005 102: 18520-18525; published online before print December 9 2005, 10.1073/pnas.0505774102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Annelie Everts-van der Wind, Denis M. Larkin, Cheryl A. Green, Janice S. Elliott, Colleen A. Olmstead, Readman Chiu, Jacqueline E. Schein, Marco A. Marra, James E. Womack, and Harris A. Lewin
A high-resolution whole-genome cattle–human comparative map reveals details of mammalian chromosome evolution
PNAS 2005 102: 18526-18531; published online before print December 9 2005, 10.1073/pnas.0509285102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Hiroyuki O. Ishikawa, Shunsuke Higashi, Tomonori Ayukawa, Takeshi Sasamura, Motoo Kitagawa, Kenichi Harigaya, Kazuhisa Aoki, Nobuhiro Ishida, Yutaka Sanai, and Kenji Matsuno
Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc
PNAS 2005 102: 18532-18537; published online before print December 12 2005, 10.1073/pnas.0504115102 [Abstract] [Full Text] [Figures Only] [PDF]  

Eiichi Sato, Sara H. Olson, Jiyoung Ahn, Brian Bundy, Hiroyoshi Nishikawa, Feng Qian, Achim A. Jungbluth, Denise Frosina, Sacha Gnjatic, Christine Ambrosone, James Kepner, Tosin Odunsi, Gerd Ritter, Shashikant Lele, Yao-Tseng Chen, Haruo Ohtani, Lloyd J. Old, and Kunle Odunsi
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
PNAS 2005 102: 18538-18543; published online before print December 12 2005, 10.1073/pnas.0509182102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables] OPEN ACCESS ARTICLE  

Domenico Rosa, Giulietta Saletti, Ennio De Gregorio, Francesca Zorat, Consuelo Comar, Ugo D'Oro, Sandra Nuti, Michael Houghton, Vincenzo Barnaba, Gabriele Pozzato, and Sergio Abrignani
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
PNAS 2005 102: 18544-18549; published online before print December 9 2005, 10.1073/pnas.0509402102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Elliot M. Friedman, Mary S. Hayney, Gayle D. Love, Heather L. Urry, Melissa A. Rosenkranz, Richard J. Davidson, Burton H. Singer, and Carol D. Ryff
Social relationships, sleep quality, and interleukin-6 in aging women
PNAS 2005 102: 18757-18762; published online before print December 8 2005, 10.1073/pnas.0509281102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Medical Sciences

T. D. Noakes, K. Sharwood, D. Speedy, T. Hew, S. Reid, J. Dugas, C. Almond, P. Wharam, and L. Weschler
Three independent biological mechanisms cause exercise-associated hyponatremia: Evidence from 2,135 weighed competitive athletic performances
PNAS 2005 102: 18550-18555; published online before print December 12 2005, 10.1073/pnas.0509096102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Joseph Lotem, Dvir Netanely, Eytan Domany, and Leo Sachs
Human cancers overexpress genes that are specific to a variety of normal human tissues
PNAS 2005 102: 18556-18561; published online before print December 8 2005, 10.1073/pnas.0509360102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jason S. Knight, Nikhil Sharma, and Erle S. Robertson
Epstein–Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase
PNAS 2005 102: 18562-18566; published online before print December 13 2005, 10.1073/pnas.0503886102 [Abstract] [Full Text] [Figures Only] [PDF]  

Desheng Lu, Howard B. Cottam, Maripat Corr, and Dennis A. Carson
Repression of {beta}-catenin function in malignant cells by nonsteroidal antiinflammatory drugs
PNAS 2005 102: 18567-18571; published online before print December 13 2005, 10.1073/pnas.0509316102 [Abstract] [Full Text] [Figures Only] [PDF]  

Microbiology

Tatiana G. Senkevich, Suany Ojeda, Alan Townsley, Gretchen E. Nelson, and Bernard Moss
Poxvirus multiprotein entry–fusion complex
PNAS 2005 102: 18572-18577; published online before print December 8 2005, 10.1073/pnas.0509239102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Carol S. Inatsuka, Steven M. Julio, and Peggy A. Cotter
Bordetella filamentous hemagglutinin plays a critical role in immunomodulation, suggesting a mechanism for host specificity
PNAS 2005 102: 18578-18583; published online before print December 9 2005, 10.1073/pnas.0507910102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Paul D. Cotter, Paula M. O'Connor, Lorraine A. Draper, Elaine M. Lawton, Lucy H. Deegan, Colin Hill, and R. Paul Ross
Posttranslational conversion of L-serines to D-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147
PNAS 2005 102: 18584-18589; published online before print December 8 2005, 10.1073/pnas.0509371102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

G. Gabriel, B. Dauber, T. Wolff, O. Planz, H.-D. Klenk, and J. Stech
The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host
PNAS 2005 102: 18590-18595; published online before print December 8 2005, 10.1073/pnas.0507415102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ke Shi, C. Kent Brown, Zu-Yi Gu, Briana K. Kozlowicz, Gary M. Dunny, Douglas H. Ohlendorf, and Cathleen A. Earhart
Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis
PNAS 2005 102: 18596-18601; published online before print December 8 2005, 10.1073/pnas.0506163102 [Abstract] [Full Text] [Figures Only] [PDF]  

Arun V. Divakaruni, Rachel R. Ogorzalek Loo, Yongming Xie, Joseph A. Loo, and James W. Gober
The cell-shape protein MreC interacts with extracytoplasmic proteins including cell wall assembly complexes in Caulobacter crescentus
PNAS 2005 102: 18602-18607; published online before print December 12 2005, 10.1073/pnas.0507937102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Natalie A. Dye, Zachary Pincus, Julie A. Theriot, Lucy Shapiro, and Zemer Gitai
Two independent spiral structures control cell shape in Caulobacter
PNAS 2005 102: 18608-18613; published online before print December 12 2005, 10.1073/pnas.0507708102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Mario A. Ruggero and Andrei N. Temchin
Unexceptional sharpness of frequency tuning in the human cochlea
PNAS 2005 102: 18614-18619; published online before print December 12 2005, 10.1073/pnas.0509323102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

G. Gobbi, F. R. Bambico, R. Mangieri, M. Bortolato, P. Campolongo, M. Solinas, T. Cassano, M. G. Morgese, G. Debonnel, A. Duranti, A. Tontini, G. Tarzia, M. Mor, V. Trezza, S. R. Goldberg, V. Cuomo, and D. Piomelli
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
PNAS 2005 102: 18620-18625; published online before print December 13 2005, 10.1073/pnas.0509591102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

R. Christopher deCharms, Fumiko Maeda, Gary H. Glover, David Ludlow, John M. Pauly, Deepak Soneji, John D. E. Gabrieli, and Sean C. Mackey
Control over brain activation and pain learned by using real-time functional MRI
PNAS 2005 102: 18626-18631; published online before print December 13 2005, 10.1073/pnas.0505210102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Linda Ste. Marie, Serge Luquet, Toby B. Cole, and Richard D. Palmiter
Modulation of neuropeptide Y expression in adult mice does not affect feeding
PNAS 2005 102: 18632-18637; published online before print December 8 2005, 10.1073/pnas.0509240102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Vikaas S. Sohal and John R. Huguenard
Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types
PNAS 2005 102: 18638-18643; published online before print December 8 2005, 10.1073/pnas.0509291102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Alysson R. Muotri, Kinichi Nakashima, Nicolas Toni, Vladislav M. Sandler, and Fred H. Gage
Development of functional human embryonic stem cell-derived neurons in mouse brain
PNAS 2005 102: 18644-18648; published online before print December 13 2005, 10.1073/pnas.0509315102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Angelo Contarino and Francesco Papaleo
The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal
PNAS 2005 102: 18649-18654; published online before print December 8 2005, 10.1073/pnas.0506999102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Tomer Shmiel, Rotem Drori, Oren Shmiel, Yoram Ben-Shaul, Zoltan Nadasdy, Moshe Shemesh, Mina Teicher, and Moshe Abeles
Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior
PNAS 2005 102: 18655-18657; published online before print December 9 2005, 10.1073/pnas.0509346102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anna M. Colangelo, Nicoletta Finotti, Michela Ceriani, Lilia Alberghina, Enzo Martegani, Luigi Aloe, Laura Lenzi, and Rita Levi-Montalcini
Recombinant human nerve growth factor with a marked activity in vitro and in vivo
PNAS 2005 102: 18658-18663; published online before print December 8 2005, 10.1073/pnas.0508734102 [Abstract] [Full Text] [Figures Only] [PDF]  

J.-S. Rhee, L. Y. Li, O.-H. Shin, J.-C. Rah, J. Rizo, T. C. Südhof, and C. Rosenmund
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1
PNAS 2005 102: 18664-18669; published online before print December 13 2005, 10.1073/pnas.0509153102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Yoichi Kondo, David A. Wenger, Vittorio Gallo, and Ian D. Duncan
From The Cover: Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in mice
PNAS 2005 102: 18670-18675; published online before print December 13 2005, 10.1073/pnas.0506473102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Wanli W. Smith, Zhong Pei, Haibing Jiang, Darren J. Moore, Yideng Liang, Andrew B. West, Valina L. Dawson, Ted M. Dawson, and Christopher A. Ross
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
PNAS 2005 102: 18676-18681; published online before print December 13 2005, 10.1073/pnas.0508052102 [Abstract] [Full Text] [Figures Only] [PDF]  

B. de Gelder, J. S. Morris, and R. J. Dolan
Unconscious fear influences emotional awareness of faces and voices
PNAS 2005 102: 18682-18687; published online before print December 13 2005, 10.1073/pnas.0509179102 [Abstract] [Full Text] [Figures Only] [PDF]  

Alexander A. Nikonov, Thomas E. Finger, and John Caprio
Beyond the olfactory bulb: An odotopic map in the forebrain
PNAS 2005 102: 18688-18693; published online before print December 7 2005, 10.1073/pnas.0505241102 [Abstract] [Full Text] [Figures Only] [PDF]  

Shengjun Chang, Tian ran Ma, R. Dennis Miranda, Maureen E. Balestra, Robert W. Mahley, and Yadong Huang
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
PNAS 2005 102: 18694-18699; published online before print December 12 2005, 10.1073/pnas.0508254102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Shiming Ye, Yadong Huang, Karin Müllendorff, Liming Dong, Gretchen Giedt, Elaine C. Meng, Fred E. Cohen, Irwin D. Kuntz, Karl H. Weisgraber, and Robert W. Mahley
Apolipoprotein (apo) E4 enhances amyloid {beta} peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target
PNAS 2005 102: 18700-18705; published online before print December 12 2005, 10.1073/pnas.0508693102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE