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Table of Contents

February 22, 2005; 102 (8)  [Index By Author]  [Cover Photo]  [Masthead (PDF)]

FROM THE COVER

Building Macdonald polynomials

Second role for PTEN tumor suppressor

Ubiquitin acts as endocytosis signal (A

Ubiquitin acts as endocytosis signal (B

Economics of hospital infection control

IN THIS ISSUE

COMMENTARIES

PHYSICAL SCIENCES
    Engineering
    Mathematics

SOCIAL SCIENCES
    Economic Sciences

BIOLOGICAL SCIENCES
    Applied Biological Sciences
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Ecology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Physiology
    Plant Biology
    Population Biology
    Psychology
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IN THIS ISSUE

This Week in PNAS
PNAS 2005 102: 2673-2674. [Full Text] [Figures Only] [PDF]  

COMMENTARIES

Steven A. Kliewer
Cholesterol detoxification by the nuclear pregnane X receptor
PNAS 2005 102: 2675-2676; published online before print February 14 2005, 10.1073/pnas.0500159102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 2198 in issue 6 of volume 102

David Stokoe and Joseph F. Costello
Phosphatase and tensin homologue growth suppression without phosphatase
PNAS 2005 102: 2677-2678; published online before print February 14 2005, 10.1073/pnas.0500089102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 2703

Rubén Claudio Aguilar and Beverly Wendland
Endocytosis of membrane receptors: Two pathways are better than one
PNAS 2005 102: 2679-2680; published online before print February 14 2005, 10.1073/pnas.0500213102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 2760
See companion article on page 2766

Lee Kroos
Eukaryotic-like signaling and gene regulation in a prokaryote that undergoes multicellular development
PNAS 2005 102: 2681-2682; published online before print February 14 2005, 10.1073/pnas.0500157102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 3010

Leslie A. Real
The community-wide dilemma of hospital-acquired drug resistance
PNAS 2005 102: 2683-2684; published online before print February 14 2005, 10.1073/pnas.0500088102 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 3153

PHYSICAL SCIENCES

Engineering

Kiran Raosaheb Patil and Jens Nielsen
Uncovering transcriptional regulation of metabolism by using metabolic network topology
PNAS 2005 102: 2685-2689; published online before print February 14 2005, 10.1073/pnas.0406811102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mathematics

J. Haglund, M. Haiman, and N. Loehr
From the Cover: Combinatorial theory of Macdonald polynomials I: Proof of Haglund's formula
PNAS 2005 102: 2690-2696; published online before print January 13 2005, 10.1073/pnas.0408497102 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Economic Sciences

David L. Smith, Simon A. Levin, and Ramanan Laxminarayan
From The Cover: Strategic interactions in multi-institutional epidemics of antibiotic resistance
PNAS 2005 102: 3153-3158; published online before print January 26 2005, 10.1073/pnas.0409523102 [Abstract] [Full Text] [Figures Only] [PDF]  
See Commentary on page 2683

BIOLOGICAL SCIENCES

Applied Biological Sciences

Mark R. Proctor, Edward J. Taylor, Didier Nurizzo, Johan P. Turkenburg, Ruth M. Lloyd, Maria Vardakou, Gideon J. Davies, and Harry J. Gilbert
Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A
PNAS 2005 102: 2697-2702; published online before print February 11 2005, 10.1073/pnas.0500051102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Biochemistry

Koichi Okumura, Mujun Zhao, Ronald A. DePinho, Frank B. Furnari, and Webster K. Cavenee
From the Cover: Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor
PNAS 2005 102: 2703-2706; published online before print January 19 2005, 10.1073/pnas.0409370102 [Abstract] [Full Text] [Figures Only] [PDF]  
See Commentary on page 2677

Junhui Zhang, Jessica Simisky, Francis T. F. Tsai, and David S. Geller
A critical role of helix 3–helix 5 interaction in steroid hormone receptor function
PNAS 2005 102: 2707-2712; published online before print February 14 2005, 10.1073/pnas.0409663102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jason F. Flores, Charles R. Fisher, Susan L. Carney, Brian N. Green, John K. Freytag, Stephen W. Schaeffer, and William E. Royer, Jr.
Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin
PNAS 2005 102: 2713-2718; published online before print February 14 2005, 10.1073/pnas.0407455102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Elizabeth Buck and James A. Wells
Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor
PNAS 2005 102: 2719-2724; published online before print February 14 2005, 10.1073/pnas.0500016102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Tadashi Yamashita, Yun-Ping Wu, Roger Sandhoff, Norbert Werth, Hiroki Mizukami, Jessica M. Ellis, Jeffrey L. Dupree, Rudolf Geyer, Konrad Sandhoff, and Richard L. Proia
Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon–glial interactions
PNAS 2005 102: 2725-2730; published online before print February 14 2005, 10.1073/pnas.0407785102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Haiyu Zhang, María R. Gómez-García, Michael R. W. Brown, and Arthur Kornberg
Inorganic polyphosphate in Dictyostelium discoideum: Influence on development, sporulation, and predation
PNAS 2005 102: 2731-2735; published online before print February 8 2005, 10.1073/pnas.0500023102 [Abstract] [Full Text] [Figures Only] [PDF]  

Biophysics

H. El-Samad, H. Kurata, J. C. Doyle, C. A. Gross, and M. Khammash
Surviving heat shock: Control strategies for robustness and performance
PNAS 2005 102: 2736-2741; published online before print January 24 2005, 10.1073/pnas.0403510102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Online Correction to Table 1]  
See Commentary on page 4219

J. P. Johnson, Jr. and William N. Zagotta
The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path
PNAS 2005 102: 2742-2747; published online before print February 14 2005, 10.1073/pnas.0408323102 [Abstract] [Full Text] [Figures Only] [PDF]  

Tetsunari Kimura, Takanori Uzawa, Koichiro Ishimori, Isao Morishima, Satoshi Takahashi, Takashi Konno, Shuji Akiyama, and Tetsuro Fujisawa
Specific collapse followed by slow hydrogen-bond formation of {beta}-sheet in the folding of single-chain monellin
PNAS 2005 102: 2748-2753; published online before print February 14 2005, 10.1073/pnas.0407982102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Benjamin Schuler, Everett A. Lipman, Peter J. Steinbach, Michael Kumke, and William A. Eaton
Polyproline and the "spectroscopic ruler" revisited with single-molecule fluorescence
PNAS 2005 102: 2754-2759; published online before print February 7 2005, 10.1073/pnas.0408164102 [Abstract] [Full Text] [Figures Only] [PDF]  

Cell Biology

Sara Sigismund, Tanja Woelk, Claudia Puri, Elena Maspero, Carlo Tacchetti, Pietro Transidico, Pier Paolo Di Fiore, and Simona Polo
From the Cover: Clathrin-independent endocytosis of ubiquitinated cargos
PNAS 2005 102: 2760-2765; published online before print February 8 2005, 10.1073/pnas.0409817102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
See Commentary on page 2679

Hong Chen and Pietro De Camilli
From the Cover: The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin
PNAS 2005 102: 2766-2771; published online before print February 8 2005, 10.1073/pnas.0409719102 [Abstract] [Full Text] [Figures Only] [PDF]  
See Commentary on page 2679

Marek Cyrklaff, Cristina Risco, Jose Jesús Fernández, Maria Victoria Jiménez, Mariano Estéban, Wolfgang Baumeister, and José L. Carrascosa
Cryo-electron tomography of vaccinia virus
PNAS 2005 102: 2772-2777; published online before print February 7 2005, 10.1073/pnas.0409825102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Zhigang Lu, Chuanmao Zhang, and Zhonghe Zhai
Nucleoplasmin regulates chromatin condensation during apoptosis
PNAS 2005 102: 2778-2783; published online before print February 7 2005, 10.1073/pnas.0405374102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Kai-Feng Xu, Xiaoyan Shen, Hewang Li, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70
PNAS 2005 102: 2784-2789; published online before print February 10 2005, 10.1073/pnas.0409871102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Elöd Z. Szabó, Masayuki Numata, Viktoria Lukashova, Pietro Iannuzzi, and John Orlowski
{beta}-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform
PNAS 2005 102: 2790-2795; published online before print February 7 2005, 10.1073/pnas.0407444102 [Abstract] [Full Text] [Figures Only] [PDF]  

Noriaki Kitamura, Masahiko Ikekita, Takeshi Sato, Yoshihiro Akimoto, Yasumaru Hatanaka, Hayato Kawakami, Mitsushi Inomata, and Kiyoshi Furukawa
Mouse Na+/K+-ATPase {beta}1-subunit has a K+-dependent cell adhesion activity for {beta}-GlcNAc-terminating glycans
PNAS 2005 102: 2796-2801; published online before print February 10 2005, 10.1073/pnas.0409344102 [Abstract] [Full Text] [Figures Only] [PDF]  

Qinghong Zhang, Amanda Nottke, and Richard H. Goodman
Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis
PNAS 2005 102: 2802-2807; published online before print February 11 2005, 10.1073/pnas.0409373102 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Igor Martianov, Stefano Brancorsini, Raffaella Catena, Anne Gansmuller, Noora Kotaja, Martti Parvinen, Paolo Sassone-Corsi, and Irwin Davidson
Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis
PNAS 2005 102: 2808-2813; published online before print February 14 2005, 10.1073/pnas.0406060102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yoko Omoto, Richard Lathe, Margaret Warner, and Jan-Åke Gustafsson
Early onset of puberty and early ovarian failure in CYP7B1 knockout mice
PNAS 2005 102: 2814-2819; published online before print February 14 2005, 10.1073/pnas.0500198102 [Abstract] [Full Text] [Figures Only] [PDF]  

Ching-Wei Luo, Elizabeth M. Dewey, Satoko Sudo, John Ewer, Sheau Yu Hsu, Hans-Willi Honegger, and Aaron J. W. Hsueh
Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2
PNAS 2005 102: 2820-2825; published online before print February 9 2005, 10.1073/pnas.0409916102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

Thorsten B. H. Reusch, Anneli Ehlers, August Hämmerli, and Boris Worm
Ecosystem recovery after climatic extremes enhanced by genotypic diversity
PNAS 2005 102: 2826-2831; published online before print February 14 2005, 10.1073/pnas.0500008102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Evolution

Sara L. Sawyer, Lily I. Wu, Michael Emerman, and Harmit S. Malik
Positive selection of primate TRIM5{alpha} identifies a critical species-specific retroviral restriction domain
PNAS 2005 102: 2832-2837; published online before print February 2 2005, 10.1073/pnas.0409853102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
See Commentary on page 3179

Jenni E. Pettay, Loeske E. B. Kruuk, Jukka Jokela, and Virpi Lummaa
Heritability and genetic constraints of life-history trait evolution in preindustrial humans
PNAS 2005 102: 2838-2843; published online before print February 8 2005, 10.1073/pnas.0406709102 [Abstract] [Full Text] [PDF]  

Yunling Wang, Lene Jensen, Peter Højrup, and David Morse
Synthesis and degradation of dinoflagellate plastid-encoded psbA proteins are light-regulated, not circadian-regulated
PNAS 2005 102: 2844-2849; published online before print February 9 2005, 10.1073/pnas.0406522102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Kiran Raosaheb Patil and Jens Nielsen
Uncovering transcriptional regulation of metabolism by using metabolic network topology
PNAS 2005 102: 2685-2689; published online before print February 14 2005, 10.1073/pnas.0406811102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gene W. Yeo, Eric Van Nostrand, Dirk Holste, Tomaso Poggio, and Christopher B. Burge
Identification and analysis of alternative splicing events conserved in human and mouse
PNAS 2005 102: 2850-2855; published online before print February 11 2005, 10.1073/pnas.0409742102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Nilangshu Das, Majda Valjavec-Gratian, Ashish N. Basuray, Richard A. Fekete, Peter P. Papp, Johan Paulsson, and Dhruba K. Chattoraj
Multiple homeostatic mechanisms in the control of P1 plasmid replication
PNAS 2005 102: 2856-2861; published online before print February 11 2005, 10.1073/pnas.0409790102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Igor Zwir, Dongwoo Shin, Akinori Kato, Kunihiko Nishino, Tammy Latifi, Felix Solomon, Janelle M. Hare, Henry Huang, and Eduardo A. Groisman
Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica
PNAS 2005 102: 2862-2867; published online before print February 9 2005, 10.1073/pnas.0408238102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Jackie Haines, Victoria Johnson, Kevin Pack, Nirosha Suraweera, Predrag Slijepcevic, Erik Cabuy, Margaret Coster, Mohammad Ilyas, Jennifer Wilding, Oliver Sieber, Walter Bodmer, Ian Tomlinson, and Andrew Silver
Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice
PNAS 2005 102: 2868-2873; published online before print February 14 2005, 10.1073/pnas.0500039102 [Abstract] [Full Text] [Figures Only] [PDF]  

Immunology

Julia Hauer, Stephanie Püschner, Parameswaran Ramakrishnan, Ute Simon, Martina Bongers, Christine Federle, and Hartmut Engelmann
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-{kappa}B pathway by TRAF-binding TNFRs
PNAS 2005 102: 2874-2879; published online before print February 11 2005, 10.1073/pnas.0500187102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Mansour Mohamadzadeh, Scott Olson, Warren V. Kalina, Gordon Ruthel, Gretchen L. Demmin, Kelly L. Warfield, Sina Bavari, and Todd R. Klaenhammer
Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization
PNAS 2005 102: 2880-2885; published online before print February 14 2005, 10.1073/pnas.0500098102 [Abstract] [Full Text] [Figures Only] [PDF]  

Domenico Mavilio, Gabriella Lombardo, Janet Benjamin, Diana Kim, Dean Follman, Emanuela Marcenaro, M. Angeline O'Shea, Audrey Kinter, Colin Kovacs, Alessandro Moretta, and Anthony S. Fauci
Characterization of CD56/CD16+ natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals
PNAS 2005 102: 2886-2891; published online before print February 7 2005, 10.1073/pnas.0409872102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jörg H. W. Distler, Astrid Jüngel, Lars C. Huber, Christian A. Seemayer, Charles F. Reich, III, Renate E. Gay, Beat A. Michel, Adriano Fontana, Steffen Gay, David S. Pisetsky, and Oliver Distler
The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles
PNAS 2005 102: 2892-2897; published online before print February 8 2005, 10.1073/pnas.0409781102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Margaret S. Bynoe, Christophe Viret, Richard A. Flavell, and Charles A. Janeway, Jr.
T cells from epicutaneously immunized mice are prone to T cell receptor revision
PNAS 2005 102: 2898-2903; published online before print February 11 2005, 10.1073/pnas.0409880102 [Abstract] [Full Text] [Figures Only] [PDF]  

Bozidar Purtic, Lisa A. Pitcher, Nicolai S. C. van Oers, and Christoph Wülfing
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells
PNAS 2005 102: 2904-2909; published online before print February 9 2005, 10.1073/pnas.0406867102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kavita M. Dhodapkar, Jacob L. Kaufman, Marc Ehlers, Devi K. Banerjee, Ezio Bonvini, Scott Koenig, Ralph M. Steinman, Jeffrey V. Ravetch, and Madhav V. Dhodapkar
Selective blockade of inhibitory Fc{gamma} receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
PNAS 2005 102: 2910-2915; published online before print February 9 2005, 10.1073/pnas.0500014102 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Tammara Watts, Irene Berti, Anna Sapone, Tania Gerarduzzi, Tarcisio Not, Ronald Zielke, and Alessio Fasano
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats
PNAS 2005 102: 2916-2921; published online before print February 14 2005, 10.1073/pnas.0500178102 [Abstract] [Full Text] [Figures Only] [PDF]  

P. Peter Ghoroghchian, Paul R. Frail, Kimihiro Susumu, Dana Blessington, Aaron K. Brannan, Frank S. Bates, Britton Chance, Daniel A. Hammer, and Michael J. Therien
Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging
PNAS 2005 102: 2922-2927; published online before print February 11 2005, 10.1073/pnas.0409394102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh, Benjamin Dekel, Enrique Freud, and Yair Reisner
Embryonic pig liver, pancreas, and lung as a source for transplantation: Optimal organogenesis without teratoma depends on distinct time windows
PNAS 2005 102: 2928-2933; published online before print February 14 2005, 10.1073/pnas.0500177102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Malin Sund, Yuki Hamano, Hikaru Sugimoto, Akulapalli Sudhakar, Mary Soubasakos, Udaya Yerramalla, Laura E. Benjamin, Jack Lawler, Mark Kieran, Amish Shah, and Raghu Kalluri
Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors
PNAS 2005 102: 2934-2939; published online before print February 14 2005, 10.1073/pnas.0500180102 [Abstract] [Full Text] [Figures Only] [PDF]  

Fatema A. Legrand, Paulo H. Verardi, Kenneth S. Chan, Yue Peng, Leslie A. Jones, and Tilahun D. Yilma
Vaccinia viruses with a serpin gene deletion and expressing IFN-{gamma} induce potent immune responses without detectable replication in vivo
PNAS 2005 102: 2940-2945; published online before print February 10 2005, 10.1073/pnas.0409846102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Jeffrey A. Spencer, Shelby L. Hacker, Elaine C. Davis, Robert P. Mecham, Russ H. Knutsen, Dean Y. Li, Robert D. Gerard, James A. Richardson, Eric N. Olson, and Hiromi Yanagisawa
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration
PNAS 2005 102: 2946-2951; published online before print February 14 2005, 10.1073/pnas.0500058102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Lynda S. Ostedgaard, Tatiana Rokhlina, Philip H. Karp, Philip Lashmit, Sandra Afione, Michael Schmidt, Joseph Zabner, Mark F. Stinski, Jay A. Chiorini, and Michael J. Welsh
A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia
PNAS 2005 102: 2952-2957; published online before print February 9 2005, 10.1073/pnas.0409845102 [Abstract] [Full Text] [Figures Only] [PDF]  

Jeffrey H. Fair, Bruce A. Cairns, Michael A. LaPaglia, Montserrat Caballero, W. Andrew Pleasant, Seigo Hatada, Hyung-suk Kim, Tong Gui, Larysa Pevny, Anthony A. Meyer, Darrel W. Stafford, Oliver Smithies, and Jeffrey A. Frelinger
Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro
PNAS 2005 102: 2958-2963; published online before print February 7 2005, 10.1073/pnas.0409840102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Anna V. Roschke, Samir Lababidi, Giovanni Tonon, Kristen S. Gehlhaus, Kimberly Bussey, John N. Weinstein, and Ilan R. Kirsch
Karyotypic "state" as a potential determinant for anticancer drug discovery
PNAS 2005 102: 2964-2969; published online before print February 9 2005, 10.1073/pnas.0405578102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Naoko Niho, Michihiro Mutoh, Mami Takahashi, Kazuhiko Tsutsumi, Takashi Sugimura, and Keiji Wakabayashi
Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice
PNAS 2005 102: 2970-2974; published online before print February 14 2005, 10.1073/pnas.0500153102 [Abstract] [Full Text] [Figures Only] [PDF]  

Arya Mani, Jayaram Radhakrishnan, Anita Farhi, Khary S. Carew, Carole A. Warnes, Carol Nelson-Williams, Ronald W. Day, Barbara Pober, Matthew W. State, and Richard P. Lifton
Syndromic patent ductus arteriosus: Evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder
PNAS 2005 102: 2975-2979; published online before print January 31 2005, 10.1073/pnas.0409852102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Markus Meissner, Efrosinia Krejany, Paul R. Gilson, Tania F. de Koning-Ward, Dominique Soldati, and Brendan S. Crabb
Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators
PNAS 2005 102: 2980-2985; published online before print February 14 2005, 10.1073/pnas.0500112102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Eileen Foy, Kui Li, Rhea Sumpter, Jr., Yueh-Ming Loo, Cynthia L. Johnson, Chunfu Wang, Penny Mar Fish, Mitsutoshi Yoneyama, Takashi Fujita, Stanley M. Lemon, and Michael Gale, Jr.
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling
PNAS 2005 102: 2986-2991; published online before print February 14 2005, 10.1073/pnas.0408707102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Kui Li, Eileen Foy, Josephine C. Ferreon, Mitsuyasu Nakamura, Allan C. M. Ferreon, Masanori Ikeda, Stuart C. Ray, Michael Gale, Jr., and Stanley M. Lemon
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
PNAS 2005 102: 2992-2997; published online before print February 14 2005, 10.1073/pnas.0408824102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Angela R. Brannon, Julia A. Maresca, Jef D. Boeke, Munira A. Basrai, and Alison A. McBride
Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein
PNAS 2005 102: 2998-3003; published online before print February 14 2005, 10.1073/pnas.0407818102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

E. G. Ruby, M. Urbanowski, J. Campbell, A. Dunn, M. Faini, R. Gunsalus, P. Lostroh, C. Lupp, J. McCann, D. Millikan, A. Schaefer, E. Stabb, A. Stevens, K. Visick, C. Whistler, and E. P. Greenberg
Complete genome sequence of Vibrio fischeri: A symbiotic bacterium with pathogenic congeners
PNAS 2005 102: 3004-3009; published online before print February 9 2005, 10.1073/pnas.0409900102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Lars Jelsbak, Michael Givskov, and Dale Kaiser
Enhancer-binding proteins with a forkhead-associated domain and the {sigma}54 regulon in Myxococcus xanthus fruiting body development
PNAS 2005 102: 3010-3015; published online before print January 24 2005, 10.1073/pnas.0409371102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
See Commentary on page 2681

Mario F. Feldman, Michael Wacker, Marcela Hernandez, Paul G. Hitchen, Cristina L. Marolda, Michael Kowarik, Howard R. Morris, Anne Dell, Miguel A. Valvano, and Markus Aebi
Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli
PNAS 2005 102: 3016-3021; published online before print February 9 2005, 10.1073/pnas.0500044102 [Abstract] [Full Text] [Figures Only] [PDF]  

Ann-Kristin Mueller, Nelly Camargo, Karine Kaiser, Cathy Andorfer, Ute Frevert, Kai Matuschewski, and Stefan H. I. Kappe
Plasmodium liver stage developmental arrest by depletion of a protein at the parasite–host interface
PNAS 2005 102: 3022-3027; published online before print February 7 2005, 10.1073/pnas.0408442102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Deborah T. Hung and John J. Mekalanos
Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner
PNAS 2005 102: 3028-3033; published online before print February 7 2005, 10.1073/pnas.0409559102 [Abstract] [Full Text] [Figures Only] [PDF]  

Neuroscience

Amyaouch Bradaïa, Frédérique Berton, Serge Ferrari, and Christian Lüscher
{beta}-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids
PNAS 2005 102: 3034-3039; published online before print February 17 2005, 10.1073/pnas.0406632102 [Abstract] [Full Text] [Figures Only] [PDF]  

Randolf Menzel, Uwe Greggers, Alan Smith, Sandra Berger, Robert Brandt, Sascha Brunke, Gesine Bundrock, Sandra Hülse, Tobias Plümpe, Frank Schaupp, Elke Schüttler, Silke Stach, Jan Stindt, Nicola Stollhoff, and Sebastian Watzl
Honey bees navigate according to a map-like spatial memory
PNAS 2005 102: 3040-3045; published online before print February 14 2005, 10.1073/pnas.0408550102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Salvatore Oddo, Antonella Caccamo, Kim N. Green, Kevin Liang, Levina Tran, Yiling Chen, Frances M. Leslie, and Frank M. LaFerla
Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease
PNAS 2005 102: 3046-3051; published online before print February 10 2005, 10.1073/pnas.0408500102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Takayoshi Ubuka, George E. Bentley, Kazuyoshi Ukena, John C. Wingfield, and Kazuyoshi Tsutsui
Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain
PNAS 2005 102: 3052-3057; published online before print February 11 2005, 10.1073/pnas.0403840102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nikolay L. Malinin, Sarah Wright, Peter Seubert, Dale Schenk, and Irene Griswold-Prenner
Amyloid-{beta} neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity
PNAS 2005 102: 3058-3063; published online before print February 14 2005, 10.1073/pnas.0408237102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Marcus J. Wirth, Silke Patz, and Petra Wahle
Transcellular induction of neuropeptide Y expression by NT4 and BDNF
PNAS 2005 102: 3064-3069; published online before print February 9 2005, 10.1073/pnas.0404712102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Giulia D'Intino, Michela Paradisi, Mercedes Fernandez, Alessandro Giuliani, Luigi Aloe, Luciana Giardino, and Laura Calzà
Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats
PNAS 2005 102: 3070-3075; published online before print February 14 2005, 10.1073/pnas.0500073102 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Andrea d'Avella and Emilio Bizzi
Shared and specific muscle synergies in natural motor behaviors
PNAS 2005 102: 3076-3081; published online before print February 11 2005, 10.1073/pnas.0500199102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Pharmacology

Sergio E. Martinez, Sandra Bruder, Anita Schultz, Ning Zheng, Joachim E. Schultz, Joseph A. Beavo, and Jürgen U. Linder
Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: Modes of ligand binding and dimerization
PNAS 2005 102: 3082-3087; published online before print February 11 2005, 10.1073/pnas.0409913102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sandra Bruder, Jürgen U. Linder, Sergio E. Martinez, Ning Zheng, Joseph A. Beavo, and Joachim E. Schultz
The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites
PNAS 2005 102: 3088-3092; published online before print February 11 2005, 10.1073/pnas.0409917102 [Abstract] [Full Text] [Figures Only] [PDF]  

Mohab M. Ibrahim, Frank Porreca, Josephine Lai, Phillip J. Albrecht, Frank L. Rice, Alla Khodorova, Gudarz Davar, Alexandros Makriyannis, Todd W. Vanderah, Heriberto P. Mata, and T. Philip Malan, Jr.
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
PNAS 2005 102: 3093-3098; published online before print February 10 2005, 10.1073/pnas.0409888102 [Abstract] [Full Text] [Figures Only] [PDF]  

Physiology

Didier X. P. Brochet, Dongmei Yang, Alessandro Di Maio, W. Jonathan Lederer, Clara Franzini-Armstrong, and Heping Cheng
Ca2+ blinks: Rapid nanoscopic store calcium signaling
PNAS 2005 102: 3099-3104; published online before print February 14 2005, 10.1073/pnas.0500059102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Susan J. Broughton, Matthew D. W. Piper, Tomoatsu Ikeya, Timothy M. Bass, Jake Jacobson, Yasmine Driege, Pedro Martinez, Ernst Hafen, Dominic J. Withers, Sally J. Leevers, and Linda Partridge
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
PNAS 2005 102: 3105-3110; published online before print February 11 2005, 10.1073/pnas.0405775102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Hongnian Guo, Judy McKinley Brewer, Ameya Champhekar, Ruth B. S. Harris, and Eric L. Bittman
Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals
PNAS 2005 102: 3111-3116; published online before print February 14 2005, 10.1073/pnas.0409734102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Plant Biology

K. Diane Jofuku, Pamela K. Omidyar, Zorana Gee, and Jack K. Okamuro
Control of seed mass and seed yield by the floral homeotic gene APETALA2
PNAS 2005 102: 3117-3122; published online before print February 11 2005, 10.1073/pnas.0409893102 [Abstract] [Full Text] [Figures Only] [PDF]  

Masa-aki Ohto, Robert L. Fischer, Robert B. Goldberg, Kenzo Nakamura, and John J. Harada
Control of seed mass by APETALA2
PNAS 2005 102: 3123-3128; published online before print February 11 2005, 10.1073/pnas.0409858102 [Abstract] [Full Text] [Figures Only] [PDF]  

Xinhua Dai, Ken-ichiro Hayashi, Hiroshi Nozaki, Youfa Cheng, and Yunde Zhao
Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis
PNAS 2005 102: 3129-3134; published online before print February 14 2005, 10.1073/pnas.0500185102 [Abstract] [Full Text] [Figures Only] [PDF]  

Riyaz A. Bhat, Marco Miklis, Elmon Schmelzer, Paul Schulze-Lefert, and Ralph Panstruga
Recruitment and interaction dynamics of plant penetration resistance components in a plasma membrane microdomain
PNAS 2005 102: 3135-3140; published online before print February 9 2005, 10.1073/pnas.0500012102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ilse Kranner, W. John Cram, Margret Zorn, Sabine Wornik, Isao Yoshimura, Edith Stabentheiner, and Hartwig W. Pfeifhofer
Antioxidants and photoprotection in a lichen as compared with its isolated symbiotic partners
PNAS 2005 102: 3141-3146; published online before print February 14 2005, 10.1073/pnas.0407716102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Ravisha R. Weerasinghe, David McK. Bird, and Nina S. Allen
Root-knot nematodes and bacterial Nod factors elicit common signal transduction events in Lotus japonicus
PNAS 2005 102: 3147-3152; published online before print February 14 2005, 10.1073/pnas.0407926102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Population Biology

David L. Smith, Simon A. Levin, and Ramanan Laxminarayan
From The Cover: Strategic interactions in multi-institutional epidemics of antibiotic resistance
PNAS 2005 102: 3153-3158; published online before print January 26 2005, 10.1073/pnas.0409523102 [Abstract] [Full Text] [Figures Only] [PDF]  
See Commentary on page 2683

Psychology

Yuka Sasaki, Wim Vanduffel, Tamara Knutsen, Christopher Tyler, and Roger Tootell
Symmetry activates extrastriate visual cortex in human and nonhuman primates
PNAS 2005 102: 3159-3163; published online before print February 14 2005, 10.1073/pnas.0500319102 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

L. T. Maloney, M. F. Dal Martello, C. Sahm, and L. Spillmann
Past trials influence perception of ambiguous motion quartets through pattern completion
PNAS 2005 102: 3164-3169; published online before print February 14 2005, 10.1073/pnas.0407157102 [Abstract] [Full Text] [Figures Only]