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January 17, 2006; 103 (3)
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Cover image: Electrophilic neurite outgrowth-promoting prostaglandin (NEPP) compounds preferentially accumulate in neurons, providing protection against oxidative insults. NEPP is shown here in red with the nerve cell-specific marker MAP-2 in green, yielding yellow when overlaid. Cell nuclei are stained blue. NEPP binds to the transcriptional regulator Keap1 by accepting both bonding electrons from the reaction partner. See the article by Satoh et al. on pages 768–773. Image courtesy of T. Satoh.

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