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Table of Contents

November 7, 2006; 103 (45)  [Index By Author]  [Cover Photo]  [Masthead (PDF)]

FROM THE COVER

Fenestra biogenesis

Male mosquito antenna hearing

Autism-associated gene variant

Depression and bone loss

Elephant self-recognition

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down arrow THIS WEEK IN PNAS

down arrow COMMENTARIES

down arrow PERSPECTIVES

down arrow PROFILES

down arrow PHYSICAL SCIENCES
    Chemistry
    Engineering
    Geology

down arrow SOCIAL SCIENCES
    Psychology
    Sustainability Science

down arrow BIOLOGICAL SCIENCES
    Agricultural Sciences
    Applied Biological Sciences
    Biochemistry
    Biophysics
    Cell Biology
    Developmental Biology
    Ecology
    Evolution
    Genetics

    Immunology
    Medical Sciences
    Microbiology
    Neuroscience
    Pharmacology
    Plant Biology
    Psychology
    Sustainability Science

down arrow CORRECTIONS

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up arrow THIS WEEK IN PNAS

In This Issue
PNAS 2006 103: 16617-16618. [Full Text] [PDF]  

up arrow COMMENTARIES

Ron Hoy
A boost for hearing in mosquitoes
PNAS 2006 103: 16619-16620; published online before print October 30 2006, 10.1073/pnas.0608105103 [Extract] [Full Text] [PDF]  
* See companion article on page 16734

Matthew W. State
A surprising METamorphosis: Autism genetics finds a common functional variant
PNAS 2006 103: 16621-16622; published online before print October 30 2006, 10.1073/pnas.0608027103 [Extract] [Full Text] [Figures Only] [PDF]  
* See companion article on page 16834

up arrow PERSPECTIVES

George D. Rose, Patrick J. Fleming, Jayanth R. Banavar, and Amos Maritan
A backbone-based theory of protein folding
PNAS 2006 103: 16623-16633; published online before print October 30 2006, 10.1073/pnas.0606843103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

up arrow PROFILES

Philip Downey
Profile of F. Stuart Chapin III
PNAS 2006 103: 16634-16636; published online before print October 31 2006, 10.1073/pnas.0608604103 [Extract] [Full Text] [Figures Only] [PDF]  

up arrow PHYSICAL SCIENCES

Chemistry

Brandon-Luke L. Seagle, Elzbieta M. Gasyna, William F. Mieler, and James R. Norris, Jr.
Photoprotection of human retinal pigment epithelium cells against blue light-induced apoptosis by melanin free radicals from Sepia officinalis
PNAS 2006 103: 16644-16648; published online before print October 30 2006, 10.1073/pnas.0605986103 [Abstract] [Full Text] [Figures Only] [PDF]  

Cameron C. Lee, Elizabeth R. Gillies, Megan E. Fox, Steven J. Guillaudeu, Jean M. J. Fréchet, Edward E. Dy, and Francis C. Szoka
A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas
PNAS 2006 103: 16649-16654; published online before print October 30 2006, 10.1073/pnas.0607705103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ryu Tashiro, Andrew H.-J. Wang, and Hiroshi Sugiyama
Photoreactivation of DNA by an Archaeal nucleoprotein Sso7d
PNAS 2006 103: 16655-16659; published online before print October 30 2006, 10.1073/pnas.0603484103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Engineering

Siva A. Vanapalli, Steven L. Ceccio, and Michael J. Solomon
Universal scaling for polymer chain scission in turbulence
PNAS 2006 103: 16660-16665; published online before print October 30 2006, 10.1073/pnas.0607933103 [Abstract] [Full Text] [Figures Only] [PDF]  

Geology

Peter Ward, Conrad Labandeira, Michel Laurin, and Robert A. Berner
Confirmation of Romer's Gap as a low oxygen interval constraining the timing of initial arthropod and vertebrate terrestrialization
PNAS 2006 103: 16818-16822; published online before print October 25 2006, 10.1073/pnas.0607824103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

up arrow SOCIAL SCIENCES

Psychology

Yi Jiang, Patricia Costello, Fang Fang, Miner Huang, and Sheng He
A gender- and sexual orientation-dependent spatial attentional effect of invisible images
PNAS 2006 103: 17048-17052; published online before print October 30 2006, 10.1073/pnas.0605678103 [Abstract] [Full Text] [Figures Only] [PDF]  

Emma K. Adam, Louise C. Hawkley, Brigitte M. Kudielka, and John T. Cacioppo
Day-to-day dynamics of experience–cortisol associations in a population-based sample of older adults
PNAS 2006 103: 17058-17063; published online before print October 30 2006, 10.1073/pnas.0605053103 [Abstract] [Full Text] [PDF]  

Sustainability Science

F. Stuart Chapin, III, Amy L. Lovecraft, Erika S. Zavaleta, Joanna Nelson, Martin D. Robards, Gary P. Kofinas, Sarah F. Trainor, Garry D. Peterson, Henry P. Huntington, and Rosamond L. Naylor
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Policy strategies to address sustainability of Alaskan boreal forests in response to a directionally changing climate
PNAS 2006 103: 16637-16643; published online before print September 28 2006, 10.1073/pnas.0606955103 [Abstract] [Full Text] [Figures Only] [PDF]  

up arrow BIOLOGICAL SCIENCES

Agricultural Sciences

David L. Hyten, Qijian Song, Youlin Zhu, Ik-Young Choi, Randall L. Nelson, Jose M. Costa, James E. Specht, Randy C. Shoemaker, and Perry B. Cregan
Impacts of genetic bottlenecks on soybean genome diversity
PNAS 2006 103: 16666-16671; published online before print October 26 2006, 10.1073/pnas.0604379103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Kaori Shiojiri, Kyutaro Kishimoto, Rika Ozawa, Soichi Kugimiya, Soichi Urashimo, Genichiro Arimura, Junichiro Horiuchi, Takaaki Nishioka, Kenji Matsui, and Junji Takabayashi
Changing green leaf volatile biosynthesis in plants: An approach for improving plant resistance against both herbivores and pathogens
PNAS 2006 103: 16672-16676; published online before print October 30 2006, 10.1073/pnas.0607780103 [Abstract] [Full Text] [Figures Only] [PDF]  

Applied Biological Sciences

Yi Xiao, Arica A. Lubin, Brian R. Baker, Kevin W. Plaxco, and Alan J. Heeger
Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex
PNAS 2006 103: 16677-16680; published online before print October 25 2006, 10.1073/pnas.0607693103 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Jin Gao, Yu Mi Kim, Herna Coe, Blaine Zern, Barbara Sheppard, and Yadong Wang
A neuroinductive biomaterial based on dopamine
PNAS 2006 103: 16681-16686; published online before print October 30 2006, 10.1073/pnas.0606237103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Biochemistry

Tohru Ono, Atsushi Kasamatsu, Shunya Oka, and Joel Moss
The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases
PNAS 2006 103: 16687-16691; published online before print October 30 2006, 10.1073/pnas.0607911103 [Abstract] [Full Text] [Figures Only] [PDF]  

Tanya S. Freedman, Holger Sondermann, Gregory D. Friedland, Tanja Kortemme, Dafna Bar-Sagi, Susan Marqusee, and John Kuriyan
A Ras-induced conformational switch in the Ras activator Son of sevenless
PNAS 2006 103: 16692-16697; published online before print October 30 2006, 10.1073/pnas.0608127103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Pilar Tijerina, Hari Bhaskaran, and Rick Russell
Nonspecific binding to structured RNA and preferential unwinding of an exposed helix by the CYT-19 protein, a DEAD-box RNA chaperone
PNAS 2006 103: 16698-16703; published online before print October 30 2006, 10.1073/pnas.0603127103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yoshihiro Baba, Kenji Hayashi, Yoko Fujii, Akiko Mizushima, Hiroshi Watarai, Minoru Wakamori, Takuro Numaga, Yasuo Mori, Masamitsu Iino, Masaki Hikida, and Tomohiro Kurosaki
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
PNAS 2006 103: 16704-16709; published online before print October 30 2006, 10.1073/pnas.0608358103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jonathan Kyle Lassila, Heidi K. Privett, Benjamin D. Allen, and Stephen L. Mayo
Combinatorial methods for small-molecule placement in computational enzyme design
PNAS 2006 103: 16710-16715; published online before print October 30 2006, 10.1073/pnas.0607691103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Paola Mussi, Lan Liao, Seong-Eun Park, Paolo Ciana, Adriana Maggi, Benita S. Katzenellenbogen, Jianming Xu, and Bert W. O'Malley
Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland
PNAS 2006 103: 16716-16721; published online before print October 25 2006, 10.1073/pnas.0607768103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Margareta K. Sorenson and Seth A. Darst
Disulfide cross-linking indicates that FlgM-bound and free {sigma}28 adopt similar conformations
PNAS 2006 103: 16722-16727; published online before print October 30 2006, 10.1073/pnas.0606482103 [Abstract] [Full Text] [Figures Only] [PDF]  

Jason M. Crawford, Blair C. R. Dancy, Eric A. Hill, Daniel W. Udwary, and Craig A. Townsend
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase
PNAS 2006 103: 16728-16733; published online before print October 27 2006, 10.1073/pnas.0604112103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Joseph C. Jackson and Daniel Robert
From the Cover: Nonlinear auditory mechanism enhances female sounds for male mosquitoes
PNAS 2006 103: 16734-16739; published online before print October 26 2006, 10.1073/pnas.0606319103 [Abstract] [Full Text] [Figures Only] [PDF]  
* See Commentary on page 16619

Chong Fang, Alessandro Senes, Lidia Cristian, William F. DeGrado, and Robin M. Hochstrasser
Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer
PNAS 2006 103: 16740-16745; published online before print October 30 2006, 10.1073/pnas.0608243103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text]  

Megan J. Anderson, Carl L. Hansen, and Stephen R. Quake
Phase knowledge enables rational screens for protein crystallization
PNAS 2006 103: 16746-16751; published online before print October 30 2006, 10.1073/pnas.0605293103 [Abstract] [Full Text] [Figures Only] [PDF]  

Ting Lu, Tongye Shen, Chenghang Zong, Jeff Hasty, and Peter G. Wolynes
Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space
PNAS 2006 103: 16752-16757; published online before print October 27 2006, 10.1073/pnas.0607698103 [Abstract] [Full Text] [Figures Only] [PDF]  

Richard P. Sear and Martin Howard
Modeling dual pathways for the metazoan spindle assembly checkpoint
PNAS 2006 103: 16758-16763; published online before print October 25 2006, 10.1073/pnas.0603174103 [Abstract] [Full Text] [Figures Only] [PDF]  

Scott L. Crick, Murali Jayaraman, Carl Frieden, Ronald Wetzel, and Rohit V. Pappu
Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions
PNAS 2006 103: 16764-16769; published online before print October 30 2006, 10.1073/pnas.0608175103 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Cell Biology

Sofia Ioannidou, Katrin Deinhardt, Jadwiga Miotla, John Bradley, Eunice Cheung, Steven Samuelsson, Yin-Shan Ng, and David T. Shima
From the Cover: An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis
PNAS 2006 103: 16770-16775; published online before print October 30 2006, 10.1073/pnas.0603501103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Bin Zheng, Tingdong Tang, Nan Tang, Krystyna Kudlicka, Kazuaki Ohtsubo, Phuong Ma, Jamey D. Marth, Marilyn G. Farquhar, and Eero Lehtonen
Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics
PNAS 2006 103: 16776-16781; published online before print October 31 2006, 10.1073/pnas.0607974103 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Melissa M. Harrison, Craig J. Ceol, Xiaowei Lu, and H. Robert Horvitz
Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex
PNAS 2006 103: 16782-16787; published online before print October 30 2006, 10.1073/pnas.0608461103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Kyoung-Won Cho, Jae-Young Kim, Soo-Jin Song, Elizabeth Farrell, Maxwell C. Eblaghie, Hee-Jin Kim, Cheryll Tickle, and Han-Sung Jung
Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development
PNAS 2006 103: 16788-16793; published online before print October 27 2006, 10.1073/pnas.0604645103 [Abstract] [Full Text] [Figures Only] [PDF]  

Xiao Guan, Brooke W. Middlebrooks, Sherry Alexander, and Steven A. Wasserman
Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila
PNAS 2006 103: 16794-16799; published online before print October 30 2006, 10.1073/pnas.0607616103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hanbing Zhong, Xinrong Wu, Haigen Huang, Qichang Fan, Zuoyan Zhu, and Shuo Lin
Vertebrate MAX-1 is required for vascular patterning in zebrafish
PNAS 2006 103: 16800-16805; published online before print October 25 2006, 10.1073/pnas.0603959103 [Abstract] [Full Text] [Figures Only] [PDF]  

Paul Gadue, Tara L. Huber, Patrick J. Paddison, and Gordon M. Keller
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells
PNAS 2006 103: 16806-16811; published online before print October 31 2006, 10.1073/pnas.0603916103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

Alfonso Valiente-Banuet, Adolfo Vital Rumebe, Miguel Verdú, and Ragan M. Callaway
Modern Quaternary plant lineages promote diversity through facilitation of ancient Tertiary lineages
PNAS 2006 103: 16812-16817; published online before print October 26 2006, 10.1073/pnas.0604933103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Evolution

Peter Ward, Conrad Labandeira, Michel Laurin, and Robert A. Berner
Confirmation of Romer's Gap as a low oxygen interval constraining the timing of initial arthropod and vertebrate terrestrialization
PNAS 2006 103: 16818-16822; published online before print October 25 2006, 10.1073/pnas.0607824103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Sergey Gavrilets and Aaron Vose
The dynamics of Machiavellian intelligence
PNAS 2006 103: 16823-16828; published online before print October 30 2006, 10.1073/pnas.0601428103 [Abstract] [Full Text] [Figures Only] [PDF]  

GuangJun Zhang and Martin J. Cohn
Hagfish and lancelet fibrillar collagens reveal that type II collagen-based cartilage evolved in stem vertebrates
PNAS 2006 103: 16829-16833; published online before print October 31 2006, 10.1073/pnas.0605630103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Genetics

Daniel B. Campbell, James S. Sutcliffe, Philip J. Ebert, Roberto Militerni, Carmela Bravaccio, Simona Trillo, Maurizio Elia, Cindy Schneider, Raun Melmed, Roberto Sacco, Antonio M. Persico, and Pat Levitt
From the Cover: A genetic variant that disrupts MET transcription is associated with autism
PNAS 2006 103: 16834-16839; published online before print October 19 2006, 10.1073/pnas.0605296103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
* See Commentary on page 16621

Dena Johnson-Schlitz and William R. Engels
Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants
PNAS 2006 103: 16840-16845; published online before print October 30 2006, 10.1073/pnas.0607904103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Nadia Anikeeva, Tatiana Lebedeva, Aaron R. Clapp, Ellen R. Goldman, Michael L. Dustin, Hedi Mattoussi, and Yuri Sykulev
Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response
PNAS 2006 103: 16846-16851; published online before print October 31 2006, 10.1073/pnas.0607771103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Eli C. Lewis and Charles A. Dinarello
Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
PNAS 2006 103: 16852-16857; published online before print October 30 2006, 10.1073/pnas.0607917103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

Kristin Michel, Chansak Suwanchaichinda, Isabelle Morlais, Louis Lambrechts, Anna Cohuet, Parfait H. Awono-Ambene, Frederic Simard, Didier Fontenille, Michael R. Kanost, and Fotis C. Kafatos
Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum
PNAS 2006 103: 16858-16863; published online before print October 25 2006, 10.1073/pnas.0608033103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Medical Sciences

Brandon-Luke L. Seagle, Elzbieta M. Gasyna, William F. Mieler, and James R. Norris, Jr.
Photoprotection of human retinal pigment epithelium cells against blue light-induced apoptosis by melanin free radicals from Sepia officinalis
PNAS 2006 103: 16644-16648; published online before print October 30 2006, 10.1073/pnas.0605986103 [Abstract] [Full Text] [Figures Only] [PDF]  

Kumar Pandya, Hyung-Suk Kim, and Oliver Smithies
Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
PNAS 2006 103: 16864-16869; published online before print October 26 2006, 10.1073/pnas.0607700103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Yiguo Hu, Sarah Swerdlow, Theodore M. Duffy, Roberto Weinmann, Francis Y. Lee, and Shaoguang Li
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
PNAS 2006 103: 16870-16875; published online before print October 31 2006, 10.1073/pnas.0606509103 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Raz Yirmiya, Inbal Goshen, Alon Bajayo, Tirzah Kreisel, Sharon Feldman, Joseph Tam, Victoria Trembovler, Valér Csernus, Esther Shohami, and Itai Bab
From the Cover: Depression induces bone loss through stimulation of the sympathetic nervous system
PNAS 2006 103: 16876-16881; published online before print October 30 2006, 10.1073/pnas.0604234103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Jean S. Oak, Jonathan A. Deane, Michael G. Kharas, Ji Luo, Thomas E. Lane, Lewis C. Cantley, and David A. Fruman
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase
PNAS 2006 103: 16882-16887; published online before print October 27 2006, 10.1073/pnas.0607984103 [Abstract] [Full Text] [Figures Only] [PDF]  

Tatyana G. Vishnyakova, Roger Kurlander, Alexander V. Bocharov, Irina N. Baranova, Zhigang Chen, Mones S. Abu-Asab, Maria Tsokos, Daniela Malide, Federica Basso, Alan Remaley, Gyorgy Csako, Thomas L. Eggerman, and Amy P. Patterson
CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells
PNAS 2006 103: 16888-16893; published online before print October 27 2006, 10.1073/pnas.0602126103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Guo-Yun Chen, Hirotaka Osada, Luis F. Santamaria-Babi, and Reiji Kannagi
Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes
PNAS 2006 103: 16894-16899; published online before print October 30 2006, 10.1073/pnas.0607926103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

Wolfgang Bergmeier, Crystal L. Piffath, Tobias Goerge, Stephen M. Cifuni, Zaverio M. Ruggeri, Jerry Ware, and Denisa D. Wagner
The role of platelet adhesion receptor GPIb{alpha} far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
PNAS 2006 103: 16900-16905; published online before print October 30 2006, 10.1073/pnas.0608207103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Movies]  

Wen-Sung Lai, Bin Xu, Koen G. C. Westphal, Marta Paterlini, Berend Olivier, Paul Pavlidis, Maria Karayiorgou, and Joseph A. Gogos
Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning
PNAS 2006 103: 16906-16911; published online before print October 31 2006, 10.1073/pnas.0604994103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xingjun Fan, Lixing W. Reneker, Mark E. Obrenovich, Christopher Strauch, Rongzhu Cheng, Simon M. Jarvis, Beryl J. Ortwerth, and Vincent M. Monnier
Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model
PNAS 2006 103: 16912-16917; published online before print October 30 2006, 10.1073/pnas.0605101103 [Abstract] [Full Text] [Figures Only] [PDF]  

Sakthivel Sadayappan, Hanna Osinska, Raisa Klevitsky, John N. Lorenz, Michelle Sargent, Jeffrey D. Molkentin, Christine E. Seidman, Jonathan G. Seidman, and Jeffrey Robbins
Cardiac myosin binding protein c phosphorylation is cardioprotective
PNAS 2006 103: 16918-16923; published online before print October 30 2006, 10.1073/pnas.0607069103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Dimple Bansal, Claudia Scholl, Stefan Fröhling, Elizabeth McDowell, Benjamin H. Lee, Konstanze Döhner, Patricia Ernst, Alan J. Davidson, George Q. Daley, Leonard I. Zon, D. Gary Gilliland, and Brian J. P. Huntly
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model
PNAS 2006 103: 16924-16929; published online before print October 26 2006, 10.1073/pnas.0604579103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures]  

J. A. Kennedy, F. Barabé, B. J. Patterson, J. Bayani, J. A. Squire, D. L. Barber, and J. E. Dick
Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo
PNAS 2006 103: 16930-16935; published online before print October 31 2006, 10.1073/pnas.0604902103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Microbiology

G. J. D. Smith, X. H. Fan, J. Wang, K. S. Li, K. Qin, J. X. Zhang, D. Vijaykrishna, C. L. Cheung, K. Huang, J. M. Rayner, J. S. M. Peiris, H. Chen, R. G. Webster, and Y. Guan
Emergence and predominance of an H5N1 influenza variant in China
PNAS 2006 103: 16936-16941; published online before print October 30 2006, 10.1073/pnas.0608157103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yukiko K. Stranger-Jones, Taeok Bae, and Olaf Schneewind
Vaccine assembly from surface proteins of Staphylococcus aureus
PNAS 2006 103: 16942-16947; published online before print October 30 2006, 10.1073/pnas.0606863103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Tables]  

Ute Müh, Brian J. Hare, Breck A. Duerkop, Martin Schuster, Brian L. Hanzelka, Roger Heim, Eric R. Olson, and E. Peter Greenberg
A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal
PNAS 2006 103: 16948-16952; published online before print October 30 2006, 10.1073/pnas.0608348103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Yury Belyi, Ricarda Niggeweg, Bastian Opitz, Martin Vogelsgesang, Stefan Hippenstiel, Matthias Wilm, and Klaus Aktories
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A
PNAS 2006 103: 16953-16958; published online before print October 26 2006, 10.1073/pnas.0601562103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kazuya Kamada, Tatsuhiko Igarashi, Malcolm A. Martin, Boonruang Khamsri, Kazuki Hatcho, Tomoki Yamashita, Mikako Fujita, Tsuneo Uchiyama, and Akio Adachi
Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells
PNAS 2006 103: 16959-16964; published online before print October 25 2006, 10.1073/pnas.0608289103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text] OPEN ACCESS ARTICLE  

Neuroscience

Antoine Taly, Pierre-Jean Corringer, Thomas Grutter, Lia Prado de Carvalho, Martin Karplus, and Jean-Pierre Changeux
Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors
PNAS 2006 103: 16965-16970; published online before print October 31 2006, 10.1073/pnas.0607477103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Juan Carlos de Rivero Vaccari, Gregory P. Casey, Salman Aleem, Won-Mee Park, and Roderick A. Corriveau
NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death
PNAS 2006 103: 16971-16976; published online before print October 31 2006, 10.1073/pnas.0608068103 [Abstract] [Full Text] [Figures Only] [PDF]  

Huibin Tang and Daniel Goldman
Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade
PNAS 2006 103: 16977-16982; published online before print October 30 2006, 10.1073/pnas.0601565103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Jun Ming Wang, Ronald W. Irwin, and Roberta Diaz Brinton
Activation of estrogen receptor {alpha} increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo
PNAS 2006 103: 16983-16988; published online before print October 31 2006, 10.1073/pnas.0608128103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Abderrahman El Maarouf, Athanasios K. Petridis, and Urs Rutishauser
Use of polysialic acid in repair of the central nervous system
PNAS 2006 103: 16989-16994; published online before print October 30 2006, 10.1073/pnas.0608036103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Roberta Morosetti, Massimiliano Mirabella, Carla Gliubizzi, Aldobrando Broccolini, Luciana De Angelis, Enrico Tagliafico, Maurilio Sampaolesi, Teresa Gidaro, Manuela Papacci, Enrica Roncaglia, Sergio Rutella, Stefano Ferrari, Pietro Attilio Tonali, Enzo Ricci, and Giulio Cossu
MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle
PNAS 2006 103: 16995-17000; published online before print October 31 2006, 10.1073/pnas.0603386103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nobuya Sato, Hideo Sakata, Yuji L. Tanaka, and Masato Taira
Navigation-associated medial parietal neurons in monkeys
PNAS 2006 103: 17001-17006; published online before print October 26 2006, 10.1073/pnas.0604277103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE  

Prasad Shirvalkar, Malika Seth, Nicholas D. Schiff, and Daniel G. Herrera
Cognitive enhancement with central thalamic electrical stimulation
PNAS 2006 103: 17007-17012; published online before print October 25 2006, 10.1073/pnas.0604811103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figures] OPEN ACCESS ARTICLE  

James L. Goodson and Yiwei Wang
Valence-sensitive neurons exhibit divergent functional profiles in gregarious and asocial species
PNAS 2006 103: 17013-17017; published online before print October 27 2006, 10.1073/pnas.0606278103 [Abstract] [Full Text] [Figures Only] [PDF]  

Pharmacology

Cameron C. Lee, Elizabeth R. Gillies, Megan E. Fox, Steven J. Guillaudeu, Jean M. J. Fréchet, Edward E. Dy, and Francis C. Szoka
A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas
PNAS 2006 103: 16649-16654; published online before print October 30 2006, 10.1073/pnas.0607705103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Toshio Hayashi, Hisako Matsui-Hirai, Asaka Miyazaki-Akita, Akiko Fukatsu, Jun Funami, Qun-Fang Ding, Sumitra Kamalanathan, Yuichi Hattori, Louis J. Ignarro, and Akihisa Iguchi
Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes
PNAS 2006 103: 17018-17023; published online before print October 30 2006, 10.1073/pnas.0607873103 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Swasti Tiwari, Yuwei Zhang, Jennifer Heller, Darrell R. Abernethy, and Nikolai M. Soldatov
Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel {alpha}1C subunit
PNAS 2006 103: 17024-17029; published online before print October 27 2006, 10.1073/pnas.0606539103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

J. Ekberg, A. Jayamanne, C. W. Vaughan, S. Aslan, L. Thomas, J. Mould, R. Drinkwater, M. D. Baker, B. Abrahamsen, J. N. Wood, D. J. Adams, M. J. Christie, and R. J. Lewis
µO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
PNAS 2006 103: 17030-17035; published online before print October 31 2006, 10.1073/pnas.0601819103 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE  

Plant Biology

Antoine Danon, Núria Sánchez Coll, and Klaus Apel
Cryptochrome-1-dependent execution of programmed cell death induced by singlet oxygen in Arabidopsis thaliana
PNAS 2006 103: 17036-17041; published online before print October 30 2006, 10.1073/pnas.0608139103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Leónie Bentsink, Jemma Jowett, Corrie J. Hanhart, and Maarten Koornneef
Cloning of DOG1, a quantitative trait locus controlling seed dormancy in Arabidopsis
PNAS 2006 103: 17042-17047; published online before print October 25 2006, 10.1073/pnas.0607877103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Psychology

Yi Jiang, Patricia Costello, Fang Fang, Miner Huang, and Sheng He
A gender- and sexual orientation-dependent spatial attentional effect of invisible images
PNAS 2006 103: 17048-17052; published online before print October 30 2006, 10.1073/pnas.0605678103 [Abstract] [Full Text] [Figures Only] [PDF]  

Joshua M. Plotnik, Frans B. M. de Waal, and Diana Reiss
From the Cover: Self-recognition in an Asian elephant
PNAS 2006 103: 17053-17057; published online before print October 30 2006, 10.1073/pnas.0608062103 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sustainability Science

F. Stuart Chapin, III, Amy L. Lovecraft, Erika S. Zavaleta, Joanna Nelson, Martin D. Robards, Gary P. Kofinas, Sarah F. Trainor, Garry D. Peterson, Henry P. Huntington, and Rosamond L. Naylor
Inaugural Article by a Recently Elected Academy Member:
Inaugural Article: Policy strategies to address sustainability of Alaskan boreal forests in response to a directionally changing climate
PNAS 2006 103: 16637-16643; published online before print September 28 2006, 10.1073/pnas.0606955103 [Abstract] [Full Text] [Figures Only] [PDF]  

up arrow CORRECTIONS

Correction for Wada et al., A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes [Full Text] [Figures Only] [PDF]  

Correction for Street et al., A molecular mechanism for osmolyte-induced protein stability [Full Text] [Figures Only] [PDF]  

Correction for Kadener et al., Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila [Full Text] [PDF]  

Correction for Deshpande et al., A bio-chemo-mechanical model for cell contractility [Full Text] [PDF]  

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